Gene Set Enrichment Analysis using Fisher Exact Test¶
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import pandas as pd
import numpy as np
import matplotlib.pyplot as plt
import scipy
from scipy.stats import pearsonr
from statsmodels.stats.multitest import multipletests
import pickle
import seaborn as sns
from scipy.stats import fisher_exact
import gseapy as gp
from scipy.stats import hypergeom
import pandas as pd
import numpy as np
import matplotlib.pyplot as plt
import scipy
from scipy.stats import pearsonr
from statsmodels.stats.multitest import multipletests
import pickle
import seaborn as sns
from scipy.stats import fisher_exact
import gseapy as gp
from scipy.stats import hypergeom
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Read in the required data
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datExpr = pd.read_csv('/ReCoDE-Gene-Network-Analysis/data/data/Bcell_datExpr_pseudobulk.csv', index_col = 0)
datExpr = pd.read_csv('/ReCoDE-Gene-Network-Analysis/data/data/Bcell_datExpr_pseudobulk.csv', index_col = 0)
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with open('/ReCoDE-Gene-Network-Analysis/data/other/separated_communities.pkl', 'rb') as file:
separated_communities = pickle.load(file)
with open('/ReCoDE-Gene-Network-Analysis/data/other/separated_communities.pkl', 'rb') as file:
separated_communities = pickle.load(file)
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# Convert each module in separated_communities to a set
modules = {f'Module_{i+1}': set(community) for i, community in enumerate(separated_communities)}
# Convert each module in separated_communities to a set
modules = {f'Module_{i+1}': set(community) for i, community in enumerate(separated_communities)}
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modules
modules
Out[5]:
{'Module_1': {'AKAP14',
'ANKRD29',
'ANO1',
'ARHGAP23',
'ARHGEF39',
'C21orf62',
'CC2D2B',
'CCNA1',
'CDH6',
'CFAP99',
'CNKSR3',
'CYYR1',
'DBX2',
'DENND6A-AS1',
'DEPDC7',
'DTNA',
'FNDC5',
'GJB6',
'GJC2',
'GNG12',
'HCG9',
'HYDIN',
'IGLC4',
'IGLV5-37',
'KLHL13',
'KRT2',
'LAMA2',
'LCN2',
'LIM2',
'LIN28A',
'LINC00640',
'LINC00997',
'LINC01133',
'LINC01832',
'LINC01891',
'LINC02267',
'LNCOC1',
'MGAM',
'MOBP',
'MUCL3',
'NGFR',
'NKD2',
'NKX6-3',
'OPA1-AS1',
'OR2B11',
'PHACTR3',
'PLSCR2',
'PRLR',
'PRRT3-AS1',
'PTGES',
'RARRES2',
'REG1A',
'RNF182',
'SLC10A5',
'SLC17A7',
'SLC26A8',
'SLC28A2',
'SLC2A4',
'SLC6A3',
'SRRM5',
'STAP2',
'STARD6',
'TDRD1',
'TDRP',
'TECTA',
'TMEM255A',
'TMEM72-AS1',
'ZC2HC1B',
'ZNF462',
'ZSCAN10'},
'Module_2': {'ACTN3',
'ACVR2B-AS1',
'C10orf105',
'CALML6',
'CDC42EP1',
'DLGAP2',
'DPYD-IT1',
'EPHB2',
'ESCO2',
'FAM174A-DT',
'FOXD3',
'H3C8',
'ICA1-AS1',
'LINC01986',
'LINC02348',
'LINC02569',
'LINC02615',
'MROH8',
'PAPPA-AS1',
'PDK4-AS1',
'PRKD3-DT',
'RAB6C',
'RGPD6',
'SLC12A3',
'TFAP2A',
'UBE2Q2P16',
'WNT3A',
'ZNF503'},
'Module_3': {'BSN',
'C12orf71',
'CADM4',
'CCK',
'CLGN',
'COPDA1',
'DAGLA',
'DBH-AS1',
'FAM20C',
'IGHV3-32',
'IGKV3D-11',
'KCNQ4',
'LGALSL-DT',
'LINC01050',
'LINC01503',
'NKX6-2',
'PGAM2',
'PPP1R9A-AS1',
'PRR15',
'REEP1',
'RGL3',
'SMIM17',
'SPDYE21',
'STON2',
'TWIST2',
'ZNF32-AS2',
'ZSCAN2-AS1'},
'Module_4': {'ALDH8A1',
'CUX2',
'EPHA2',
'GLP2R',
'IGHV3-69-1',
'IGHV3-73',
'MAG',
'MEX3B',
'MOCS1',
'MTOR-AS1',
'MYO3B',
'OR2AK2',
'PCSK1',
'PITPNM2-AS1',
'PTPRD-AS1',
'SCT',
'SLC5A5',
'ST8SIA5',
'TAF1L',
'TKTL2',
'ZNF474'},
'Module_5': {'ADGRG3',
'BRME1',
'CFAP141',
'CLEC1B',
'COL11A2',
'DPYSL4',
'FAM186B',
'FSTL1',
'LDHAL6A',
'LINC00200',
'LINC01108',
'LINC02880',
'PRUNE2',
'RARRES1',
'SCARF2',
'SMIM10L2B-AS1',
'TRBJ2-4',
'UBL4B',
'VWA5B1',
'ZNF491'},
'Module_6': {'ACTL7B',
'AMPD1',
'ATP8A1-DT',
'DEPTOR-AS1',
'EDNRB-AS1',
'H3C12',
'HEATR4',
'IGKV1D-13',
'IGKV2D-30',
'LINC01823',
'LINC01990',
'MIPOL1',
'MIR130AHG',
'OR6C6',
'SLC16A14',
'SLC1A2-AS1',
'SLC49A3',
'SLC4A9',
'TGFB2-AS1'},
'Module_7': {'C1orf50-AS1',
'FOXI1',
'GYS2',
'HCG22',
'HDHD5-AS1',
'IGHV1-14',
'LINC01579',
'LINC02055',
'LINC03021_ENSG00000254319',
'MYLK3',
'NAALADL2',
'NLRP6',
'PCDHGA3',
'PRSS45P',
'RNF217-AS1',
'UNC79',
'VSTM1',
'VWA7'},
'Module_8': {'CASC9',
'CCDC28A-AS1',
'CFAP57',
'CYP2S1',
'FREY1',
'GCNT3',
'IGHV7-4-1',
'IGLV5-45',
'LINC00654',
'NHS',
'RHOXF1-AS1',
'RNF112',
'SLITRK5',
'THTPA',
'TMPRSS3',
'TRMT9B',
'TRPM1'},
'Module_9': {'ASIC3',
'BHLHE22',
'C10orf71',
'CT69',
'DNMBP-AS1',
'EDAR',
'LIF',
'MS4A4E',
'S100A16',
'SLC22A1',
'TRAV29DV5',
'TTLL7'},
'Module_10': {'ACTA2-AS1',
'CDH23',
'CHRNG',
'FAM182A',
'LINC02660',
'NKX6-1',
'PACRG',
'TAS2R39'},
'Module_11': {'ASGR2',
'GOLGA8H',
'IGKV2-26',
'LINC02057',
'LRRC49',
'TEKTIP1'},
'Module_12': {'CBY3', 'CYP2C8', 'LINC01301', 'PELP1-DT', 'PTGR1'},
'Module_13': {'DLG1-AS1', 'IQSEC2', 'KCNH6', 'LINC01980', 'LPAR4'},
'Module_14': {'DUOX2', 'HSD17B2-AS1', 'LINC01115_ENSG00000237667', 'MYO3A'},
'Module_15': {'FCN3', 'PCDHB4', 'S100A5'},
'Module_16': {'CNTNAP3', 'IGFBP2', 'USP43'},
'Module_17': {'NPM2', 'RHBDF1'},
'Module_18': {'SERTAD3-AS1', 'STXBP6'}}
Step 1: Load in Gene-Sets¶
This exercise will show how to use GMT files that contain gene-set information downloaded from the Human MSigDB Collections database.
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#Load the GMT file
def read_gmt_file(file_path):
gene_sets = {}
with open(file_path, 'r') as file:
for line in file:
parts = line.strip().split('\t')
gene_set_name = parts[0]
genes = parts[2:]
gene_sets[gene_set_name] = set(genes)
return gene_sets
#Load the GMT file
def read_gmt_file(file_path):
gene_sets = {}
with open(file_path, 'r') as file:
for line in file:
parts = line.strip().split('\t')
gene_set_name = parts[0]
genes = parts[2:]
gene_sets[gene_set_name] = set(genes)
return gene_sets
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gmt_file = '/ReCoDE-Gene-Network-Analysis/data/other/h.all.v2023.2.Hs.symbols.gmt'
gene_sets = read_gmt_file(gmt_file)
gmt_file = '/ReCoDE-Gene-Network-Analysis/data/other/h.all.v2023.2.Hs.symbols.gmt'
gene_sets = read_gmt_file(gmt_file)
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gene_sets
gene_sets
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{'HALLMARK_ADIPOGENESIS': {'ABCA1',
'ABCB8',
'ACAA2',
'ACADL',
'ACADM',
'ACADS',
'ACLY',
'ACO2',
'ACOX1',
'ADCY6',
'ADIG',
'ADIPOQ',
'ADIPOR2',
'AGPAT3',
'AIFM1',
'AK2',
'ALDH2',
'ALDOA',
'ANGPT1',
'ANGPTL4',
'APLP2',
'APOE',
'ARAF',
'ARL4A',
'ATL2',
'ATP1B3',
'ATP5PO',
'BAZ2A',
'BCKDHA',
'BCL2L13',
'BCL6',
'C3',
'CAT',
'CAVIN1',
'CAVIN2',
'CCNG2',
'CD151',
'CD302',
'CD36',
'CDKN2C',
'CHCHD10',
'CHUK',
'CIDEA',
'CMBL',
'CMPK1',
'COL15A1',
'COL4A1',
'COQ3',
'COQ5',
'COQ9',
'COX6A1',
'COX7B',
'COX8A',
'CPT2',
'CRAT',
'CS',
'CYC1',
'CYP4B1',
'DBT',
'DDT',
'DECR1',
'DGAT1',
'DHCR7',
'DHRS7',
'DHRS7B',
'DLAT',
'DLD',
'DNAJB9',
'DNAJC15',
'DRAM2',
'ECH1',
'ECHS1',
'ELMOD3',
'ELOVL6',
'ENPP2',
'EPHX2',
'ESRRA',
'ESYT1',
'ETFB',
'FABP4',
'FAH',
'FZD4',
'G3BP2',
'GADD45A',
'GBE1',
'GHITM',
'GPAM',
'GPAT4',
'GPD2',
'GPHN',
'GPX3',
'GPX4',
'GRPEL1',
'HADH',
'HIBCH',
'HSPB8',
'IDH1',
'IDH3A',
'IDH3G',
'IFNGR1',
'IMMT',
'ITGA7',
'ITIH5',
'ITSN1',
'JAGN1',
'LAMA4',
'LEP',
'LIFR',
'LIPE',
'LPCAT3',
'LPL',
'LTC4S',
'MAP4K3',
'MCCC1',
'MDH2',
'ME1',
'MGLL',
'MGST3',
'MIGA2',
'MRAP',
'MRPL15',
'MTARC2',
'MTCH2',
'MYLK',
'NABP1',
'NDUFA5',
'NDUFAB1',
'NDUFB7',
'NDUFS3',
'NKIRAS1',
'NMT1',
'OMD',
'ORM1',
'PDCD4',
'PEMT',
'PEX14',
'PFKFB3',
'PFKL',
'PGM1',
'PHLDB1',
'PHYH',
'PIM3',
'PLIN2',
'POR',
'PPARG',
'PPM1B',
'PPP1R15B',
'PRDX3',
'PREB',
'PTCD3',
'PTGER3',
'QDPR',
'RAB34',
'REEP5',
'REEP6',
'RETN',
'RETSAT',
'RIOK3',
'RMDN3',
'RNF11',
'RREB1',
'RTN3',
'SAMM50',
'SCARB1',
'SCP2',
'SDHB',
'SDHC',
'SLC19A1',
'SLC1A5',
'SLC25A1',
'SLC25A10',
'SLC27A1',
'SLC5A6',
'SLC66A3',
'SNCG',
'SOD1',
'SORBS1',
'SOWAHC',
'SPARCL1',
'SQOR',
'SSPN',
'STAT5A',
'STOM',
'SUCLG1',
'SULT1A1',
'TALDO1',
'TANK',
'TKT',
'TOB1',
'TST',
'UBC',
'UBQLN1',
'UCK1',
'UCP2',
'UQCR10',
'UQCR11',
'UQCRC1',
'UQCRQ',
'VEGFB',
'YWHAG'},
'HALLMARK_ALLOGRAFT_REJECTION': {'AARS1',
'ABCE1',
'ABI1',
'ACHE',
'ACVR2A',
'AKT1',
'APBB1',
'B2M',
'BCAT1',
'BCL10',
'BCL3',
'BRCA1',
'C2',
'CAPG',
'CARTPT',
'CCL11',
'CCL13',
'CCL19',
'CCL2',
'CCL22',
'CCL4',
'CCL5',
'CCL7',
'CCND2',
'CCND3',
'CCR1',
'CCR2',
'CCR5',
'CD1D',
'CD2',
'CD247',
'CD28',
'CD3D',
'CD3E',
'CD3G',
'CD4',
'CD40',
'CD40LG',
'CD47',
'CD7',
'CD74',
'CD79A',
'CD80',
'CD86',
'CD8A',
'CD8B',
'CD96',
'CDKN2A',
'CFP',
'CRTAM',
'CSF1',
'CSK',
'CTSS',
'CXCL13',
'CXCL9',
'CXCR3',
'DARS1',
'DEGS1',
'DYRK3',
'EGFR',
'EIF3A',
'EIF3D',
'EIF3J',
'EIF4G3',
'EIF5A',
'ELANE',
'ELF4',
'EREG',
'ETS1',
'F2',
'F2R',
'FAS',
'FASLG',
'FCGR2B',
'FGR',
'FLNA',
'FYB1',
'GALNT1',
'GBP2',
'GCNT1',
'GLMN',
'GPR65',
'GZMA',
'GZMB',
'HCLS1',
'HDAC9',
'HIF1A',
'HLA-A',
'HLA-DMA',
'HLA-DMB',
'HLA-DOA',
'HLA-DOB',
'HLA-DQA1',
'HLA-DRA',
'HLA-E',
'HLA-G',
'ICAM1',
'ICOSLG',
'IFNAR2',
'IFNG',
'IFNGR1',
'IFNGR2',
'IGSF6',
'IKBKB',
'IL10',
'IL11',
'IL12A',
'IL12B',
'IL12RB1',
'IL13',
'IL15',
'IL16',
'IL18',
'IL18RAP',
'IL1B',
'IL2',
'IL27RA',
'IL2RA',
'IL2RB',
'IL2RG',
'IL4',
'IL4R',
'IL6',
'IL7',
'IL9',
'INHBA',
'INHBB',
'IRF4',
'IRF7',
'IRF8',
'ITGAL',
'ITGB2',
'ITK',
'JAK2',
'KLRD1',
'KRT1',
'LCK',
'LCP2',
'LIF',
'LTB',
'LY75',
'LY86',
'LYN',
'MAP3K7',
'MAP4K1',
'MBL2',
'MMP9',
'MRPL3',
'MTIF2',
'NCF4',
'NCK1',
'NCR1',
'NLRP3',
'NME1',
'NOS2',
'NPM1',
'PF4',
'PRF1',
'PRKCB',
'PRKCG',
'PSMB10',
'PTPN6',
'PTPRC',
'RARS1',
'RIPK2',
'RPL39',
'RPL3L',
'RPL9',
'RPS19',
'RPS3A',
'RPS9',
'SIT1',
'SOCS1',
'SOCS5',
'SPI1',
'SRGN',
'ST8SIA4',
'STAB1',
'STAT1',
'STAT4',
'TAP1',
'TAP2',
'TAPBP',
'TGFB1',
'TGFB2',
'THY1',
'TIMP1',
'TLR1',
'TLR2',
'TLR3',
'TLR6',
'TNF',
'TPD52',
'TRAF2',
'TRAT1',
'UBE2D1',
'UBE2N',
'WARS1',
'WAS',
'ZAP70'},
'HALLMARK_ANDROGEN_RESPONSE': {'ABCC4',
'ABHD2',
'ACSL3',
'ACTN1',
'ADAMTS1',
'ADRM1',
'AKAP12',
'AKT1',
'ALDH1A3',
'ANKH',
'APPBP2',
'ARID5B',
'AZGP1',
'B2M',
'B4GALT1',
'BMPR1B',
'CAMKK2',
'CCND1',
'CCND3',
'CDC14B',
'CDK6',
'CENPN',
'DBI',
'DHCR24',
'DNAJB9',
'ELK4',
'ELL2',
'ELOVL5',
'FADS1',
'FKBP5',
'GNAI3',
'GPD1L',
'GSR',
'GUCY1A1',
'H1-0',
'HERC3',
'HMGCR',
'HMGCS1',
'HOMER2',
'HPGD',
'HSD17B14',
'IDI1',
'INPP4B',
'INSIG1',
'IQGAP2',
'ITGAV',
'KLK2',
'KLK3',
'KRT19',
'KRT8',
'LIFR',
'LMAN1',
'MAF',
'MAK',
'MAP7',
'MERTK',
'MYL12A',
'NCOA4',
'NDRG1',
'NGLY1',
'NKX3-1',
'PA2G4',
'PDLIM5',
'PGM3',
'PIAS1',
'PLPP1',
'PMEPA1',
'PTK2B',
'PTPN21',
'RAB4A',
'RPS6KA3',
'RRP12',
'SAT1',
'SCD',
'SEC24D',
'SELENOP',
'SGK1',
'SLC26A2',
'SLC38A2',
'SMS',
'SORD',
'SPCS3',
'SPDEF',
'SRF',
'SRP19',
'STEAP4',
'STK39',
'TARP',
'TMEM50A',
'TMPRSS2',
'TNFAIP8',
'TPD52',
'TSC22D1',
'UAP1',
'UBE2I',
'UBE2J1',
'VAPA',
'XRCC5',
'XRCC6',
'ZBTB10',
'ZMIZ1'},
'HALLMARK_ANGIOGENESIS': {'APOH',
'APP',
'CCND2',
'COL3A1',
'COL5A2',
'CXCL6',
'FGFR1',
'FSTL1',
'ITGAV',
'JAG1',
'JAG2',
'KCNJ8',
'LPL',
'LRPAP1',
'LUM',
'MSX1',
'NRP1',
'OLR1',
'PDGFA',
'PF4',
'PGLYRP1',
'POSTN',
'PRG2',
'PTK2',
'S100A4',
'SERPINA5',
'SLCO2A1',
'SPP1',
'STC1',
'THBD',
'TIMP1',
'TNFRSF21',
'VAV2',
'VCAN',
'VEGFA',
'VTN'},
'HALLMARK_APICAL_JUNCTION': {'ACTA1',
'ACTB',
'ACTC1',
'ACTG1',
'ACTG2',
'ACTN1',
'ACTN2',
'ACTN3',
'ACTN4',
'ADAM15',
'ADAM23',
'ADAM9',
'ADAMTS5',
'ADRA1B',
'AKT2',
'AKT3',
'ALOX15B',
'AMH',
'AMIGO1',
'AMIGO2',
'ARHGEF6',
'ARPC2',
'ATP1A3',
'B4GALT1',
'BAIAP2',
'BMP1',
'CADM2',
'CADM3',
'CALB2',
'CAP1',
'CD209',
'CD274',
'CD276',
'CD34',
'CD86',
'CD99',
'CDH1',
'CDH11',
'CDH15',
'CDH3',
'CDH4',
'CDH6',
'CDH8',
'CDK8',
'CDSN',
'CERCAM',
'CLDN11',
'CLDN14',
'CLDN15',
'CLDN18',
'CLDN19',
'CLDN4',
'CLDN5',
'CLDN6',
'CLDN7',
'CLDN8',
'CLDN9',
'CNN2',
'CNTN1',
'COL16A1',
'COL17A1',
'COL9A1',
'CRAT',
'CRB3',
'CTNNA1',
'CTNND1',
'CX3CL1',
'DHX16',
'DLG1',
'DMP1',
'DSC1',
'DSC3',
'EGFR',
'EPB41L2',
'EVL',
'EXOC4',
'FBN1',
'FLNC',
'FSCN1',
'FYB1',
'GAMT',
'GNAI1',
'GNAI2',
'GRB7',
'GTF2F1',
'HADH',
'HRAS',
'ICAM1',
'ICAM2',
'ICAM4',
'ICAM5',
'IKBKG',
'INPPL1',
'INSIG1',
'IRS1',
'ITGA10',
'ITGA2',
'ITGA3',
'ITGA9',
'ITGB1',
'ITGB4',
'JAM3',
'JUP',
'KCNH2',
'KRT31',
'LAMA3',
'LAMB3',
'LAMC2',
'LAYN',
'LDLRAP1',
'LIMA1',
'MADCAM1',
'MAP3K20',
'MAP4K2',
'MAPK11',
'MAPK13',
'MAPK14',
'MDK',
'MMP2',
'MMP9',
'MPZL1',
'MPZL2',
'MSN',
'MVD',
'MYH10',
'MYH9',
'MYL12B',
'MYL9',
'NECTIN1',
'NECTIN2',
'NECTIN3',
'NECTIN4',
'NEGR1',
'NEXN',
'NF1',
'NF2',
'NFASC',
'NHERF4',
'NLGN2',
'NLGN3',
'NRAP',
'NRTN',
'NRXN2',
'PALS1',
'PARD6G',
'PARVA',
'PBX2',
'PCDH1',
'PECAM1',
'PFN1',
'PIK3CB',
'PIK3R3',
'PKD1',
'PLCG1',
'PPP2R2C',
'PTEN',
'PTK2',
'PTPRC',
'RAC2',
'RASA1',
'RHOF',
'RRAS',
'RSU1',
'SDC3',
'SGCE',
'SHC1',
'SHROOM2',
'SIRPA',
'SKAP2',
'SLC30A3',
'SLIT2',
'SORBS3',
'SPEG',
'SRC',
'STX4',
'SYK',
'SYMPK',
'TAOK2',
'TGFBI',
'THBS3',
'THY1',
'TIAL1',
'TJP1',
'TMEM8B',
'TNFRSF11B',
'TRAF1',
'TRO',
'TSC1',
'TSPAN4',
'TUBG1',
'VASP',
'VAV2',
'VCAM1',
'VCAN',
'VCL',
'VWF',
'WASL',
'WNK4',
'YWHAH',
'ZYX'},
'HALLMARK_APICAL_SURFACE': {'ADAM10',
'ADIPOR2',
'AFAP1L2',
'AKAP7',
'APP',
'ATP6V0A4',
'ATP8B1',
'B4GALT1',
'BRCA1',
'CD160',
'CROCC',
'CRYBG1',
'CX3CL1',
'DCBLD2',
'EFNA5',
'EPHB4',
'FLOT2',
'GAS1',
'GATA3',
'GHRL',
'GSTM3',
'HSPB1',
'IL2RB',
'IL2RG',
'LYN',
'LYPD3',
'MAL',
'MDGA1',
'NCOA6',
'NTNG1',
'PCSK9',
'PKHD1',
'PLAUR',
'RHCG',
'RTN4RL1',
'SCUBE1',
'SHROOM2',
'SLC22A12',
'SLC2A4',
'SLC34A3',
'SRPX',
'SULF2',
'THY1',
'TMEM8B'},
'HALLMARK_APOPTOSIS': {'ADD1',
'AIFM3',
'ANKH',
'ANXA1',
'APP',
'ATF3',
'AVPR1A',
'BAX',
'BCAP31',
'BCL10',
'BCL2L1',
'BCL2L10',
'BCL2L11',
'BCL2L2',
'BGN',
'BID',
'BIK',
'BIRC3',
'BMF',
'BMP2',
'BNIP3L',
'BRCA1',
'BTG2',
'BTG3',
'CASP1',
'CASP2',
'CASP3',
'CASP4',
'CASP6',
'CASP7',
'CASP8',
'CASP9',
'CAV1',
'CCNA1',
'CCND1',
'CCND2',
'CD14',
'CD2',
'CD38',
'CD44',
'CD69',
'CDC25B',
'CDK2',
'CDKN1A',
'CDKN1B',
'CFLAR',
'CLU',
'CREBBP',
'CTH',
'CTNNB1',
'CYLD',
'DAP',
'DAP3',
'DCN',
'DDIT3',
'DFFA',
'DIABLO',
'DNAJA1',
'DNAJC3',
'DNM1L',
'DPYD',
'EBP',
'EGR3',
'EMP1',
'ENO2',
'ERBB2',
'ERBB3',
'EREG',
'ETF1',
'F2',
'F2R',
'FAS',
'FASLG',
'FDXR',
'FEZ1',
'GADD45A',
'GADD45B',
'GCH1',
'GNA15',
'GPX1',
'GPX3',
'GPX4',
'GSN',
'GSR',
'GSTM1',
'GUCY2D',
'H1-0',
'HGF',
'HMGB2',
'HMOX1',
'HSPB1',
'IER3',
'IFITM3',
'IFNB1',
'IFNGR1',
'IGF2R',
'IGFBP6',
'IL18',
'IL1A',
'IL1B',
'IL6',
'IRF1',
'ISG20',
'JUN',
'KRT18',
'LEF1',
'LGALS3',
'LMNA',
'LUM',
'MADD',
'MCL1',
'MGMT',
'MMP2',
'NEDD9',
'NEFH',
'PAK1',
'PDCD4',
'PDGFRB',
'PEA15',
'PLAT',
'PLCB2',
'PLPPR4',
'PMAIP1',
'PPP2R5B',
'PPP3R1',
'PPT1',
'PRF1',
'PSEN1',
'PSEN2',
'PTK2',
'RARA',
'RELA',
'RETSAT',
'RHOB',
'RHOT2',
'RNASEL',
'ROCK1',
'SAT1',
'SATB1',
'SC5D',
'SLC20A1',
'SMAD7',
'SOD1',
'SOD2',
'SPTAN1',
'SQSTM1',
'TAP1',
'TGFB2',
'TGFBR3',
'TIMP1',
'TIMP2',
'TIMP3',
'TNF',
'TNFRSF12A',
'TNFSF10',
'TOP2A',
'TSPO',
'TXNIP',
'VDAC2',
'WEE1',
'XIAP'},
'HALLMARK_BILE_ACID_METABOLISM': {'ABCA1',
'ABCA2',
'ABCA3',
'ABCA4',
'ABCA5',
'ABCA6',
'ABCA8',
'ABCA9',
'ABCD1',
'ABCD2',
'ABCD3',
'ABCG4',
'ABCG8',
'ACSL1',
'ACSL5',
'AGXT',
'AKR1D1',
'ALDH1A1',
'ALDH8A1',
'ALDH9A1',
'AMACR',
'APOA1',
'AQP9',
'AR',
'ATXN1',
'BBOX1',
'BCAR3',
'BMP6',
'CAT',
'CH25H',
'CROT',
'CYP27A1',
'CYP39A1',
'CYP46A1',
'CYP7A1',
'CYP7B1',
'CYP8B1',
'DHCR24',
'DIO1',
'DIO2',
'EFHC1',
'EPHX2',
'FADS1',
'FADS2',
'FDXR',
'GC',
'GCLM',
'GNMT',
'GNPAT',
'GSTK1',
'HACL1',
'HAO1',
'HSD17B11',
'HSD17B4',
'HSD17B6',
'HSD3B1',
'HSD3B7',
'IDH1',
'IDH2',
'IDI1',
'ISOC1',
'KLF1',
'LCK',
'LIPE',
'LONP2',
'MLYCD',
'NEDD4',
'NPC1',
'NR0B2',
'NR1H4',
'NR1I2',
'NR3C2',
'NUDT12',
'OPTN',
'PAOX',
'PECR',
'PEX1',
'PEX11A',
'PEX11G',
'PEX12',
'PEX13',
'PEX16',
'PEX19',
'PEX26',
'PEX6',
'PEX7',
'PFKM',
'PHYH',
'PIPOX',
'PNPLA8',
'PRDX5',
'PXMP2',
'RBP1',
'RETSAT',
'RXRA',
'RXRG',
'SCP2',
'SERPINA6',
'SLC22A18',
'SLC23A1',
'SLC23A2',
'SLC27A2',
'SLC27A5',
'SLC29A1',
'SLC35B2',
'SLCO1A2',
'SOAT2',
'SOD1',
'SULT1B1',
'SULT2B1',
'TFCP2L1',
'TTR'},
'HALLMARK_CHOLESTEROL_HOMEOSTASIS': {'ABCA2',
'ACAT2',
'ACSS2',
'ACTG1',
'ADH4',
'ALCAM',
'ALDOC',
'ANTXR2',
'ANXA13',
'ANXA5',
'ATF3',
'ATF5',
'ATXN2',
'AVPR1A',
'CBS',
'CD9',
'CHKA',
'CLU',
'CPEB2',
'CTNNB1',
'CXCL16',
'CYP51A1',
'DHCR7',
'EBP',
'ECH1',
'ERRFI1',
'ETHE1',
'FABP5',
'FADS2',
'FASN',
'FBXO6',
'FDFT1',
'FDPS',
'GLDC',
'GNAI1',
'GPX8',
'GSTM2',
'GUSB',
'HMGCR',
'HMGCS1',
'HSD17B7',
'IDI1',
'JAG1',
'LDLR',
'LGALS3',
'LGMN',
'LPL',
'LSS',
'MAL2',
'MVD',
'MVK',
'NFIL3',
'NIBAN1',
'NSDHL',
'PCYT2',
'PDK3',
'PLAUR',
'PLSCR1',
'PMVK',
'PNRC1',
'PPARG',
'S100A11',
'SC5D',
'SCD',
'SEMA3B',
'SQLE',
'SREBF2',
'STARD4',
'STX5',
'TM7SF2',
'TMEM97',
'TNFRSF12A',
'TP53INP1',
'TRIB3'},
'HALLMARK_COAGULATION': {'A2M',
'ACOX2',
'ADAM9',
'ANG',
'ANXA1',
'APOA1',
'APOC1',
'APOC2',
'APOC3',
'ARF4',
'BMP1',
'C1QA',
'C1R',
'C1S',
'C2',
'C3',
'C8A',
'C8B',
'C8G',
'C9',
'CAPN2',
'CAPN5',
'CASP9',
'CD9',
'CFB',
'CFD',
'CFH',
'CFI',
'CLU',
'COMP',
'CPB2',
'CPN1',
'CPQ',
'CRIP2',
'CSRP1',
'CTSB',
'CTSE',
'CTSH',
'CTSK',
'CTSO',
'CTSV',
'DCT',
'DPP4',
'DUSP14',
'DUSP6',
'F10',
'F11',
'F12',
'F13B',
'F2',
'F2RL2',
'F3',
'F8',
'F9',
'FBN1',
'FGA',
'FGG',
'FN1',
'FURIN',
'FYN',
'GDA',
'GNB2',
'GNG12',
'GP1BA',
'GP9',
'GSN',
'HMGCS2',
'HNF4A',
'HPN',
'HRG',
'HTRA1',
'ISCU',
'ITGA2',
'ITGB3',
'ITIH1',
'KLF7',
'KLK8',
'KLKB1',
'LAMP2',
'LEFTY2',
'LGMN',
'LRP1',
'LTA4H',
'MAFF',
'MASP2',
'MBL2',
'MEP1A',
'MMP1',
'MMP10',
'MMP11',
'MMP14',
'MMP15',
'MMP2',
'MMP3',
'MMP7',
'MMP8',
'MMP9',
'MSRB2',
'MST1',
'OLR1',
'P2RY1',
'PDGFB',
'PECAM1',
'PEF1',
'PF4',
'PLAT',
'PLAU',
'PLEK',
'PLG',
'PREP',
'PROC',
'PROS1',
'PROZ',
'PRSS23',
'RABIF',
'RAC1',
'RAPGEF3',
'RGN',
'S100A1',
'S100A13',
'SERPINA1',
'SERPINB2',
'SERPINC1',
'SERPINE1',
'SERPING1',
'SH2B2',
'SIRT2',
'SPARC',
'TF',
'TFPI2',
'THBD',
'THBS1',
'TIMP1',
'TIMP3',
'TMPRSS6',
'USP11',
'VWF',
'WDR1'},
'HALLMARK_COMPLEMENT': {'ACTN2',
'ADAM9',
'ADRA2B',
'AKAP10',
'ANG',
'ANXA5',
'APOA4',
'APOBEC3F',
'APOBEC3G',
'APOC1',
'ATOX1',
'BRPF3',
'C1QA',
'C1QC',
'C1R',
'C1S',
'C2',
'C3',
'C4BPB',
'C9',
'CA2',
'CALM1',
'CALM3',
'CASP1',
'CASP10',
'CASP3',
'CASP4',
'CASP5',
'CASP7',
'CASP9',
'CBLB',
'CCL5',
'CD36',
'CD40LG',
'CD46',
'CD55',
'CD59',
'CDA',
'CDH13',
'CDK5R1',
'CEBPB',
'CFB',
'CFH',
'CLU',
'COL4A2',
'CP',
'CPM',
'CPQ',
'CR1',
'CR2',
'CSRP1',
'CTSB',
'CTSC',
'CTSD',
'CTSH',
'CTSL',
'CTSO',
'CTSS',
'CTSV',
'CXCL1',
'DGKG',
'DGKH',
'DOCK10',
'DOCK4',
'DOCK9',
'DPP4',
'DUSP5',
'DUSP6',
'DYRK2',
'EHD1',
'ERAP2',
'F10',
'F2',
'F3',
'F5',
'F7',
'F8',
'FCER1G',
'FCN1',
'FDX1',
'FN1',
'FYN',
'GATA3',
'GCA',
'GMFB',
'GNAI2',
'GNAI3',
'GNB2',
'GNB4',
'GNG2',
'GNGT2',
'GP1BA',
'GP9',
'GPD2',
'GRB2',
'GZMA',
'GZMB',
'GZMK',
'HNF4A',
'HPCAL4',
'HSPA1A',
'HSPA5',
'IL6',
'IRF1',
'IRF2',
'IRF7',
'ITGAM',
'ITIH1',
'JAK2',
'KCNIP2',
'KCNIP3',
'KIF2A',
'KLK1',
'KLKB1',
'KYNU',
'L3MBTL4',
'LAMP2',
'LAP3',
'LCK',
'LCP2',
'LGALS3',
'LGMN',
'LIPA',
'LRP1',
'LTA4H',
'LTF',
'LYN',
'MAFF',
'ME1',
'MMP12',
'MMP13',
'MMP14',
'MMP15',
'MMP8',
'MSRB1',
'MT3',
'NOTCH4',
'OLR1',
'PCLO',
'PCSK9',
'PDGFB',
'PDP1',
'PFN1',
'PHEX',
'PIK3CA',
'PIK3CG',
'PIK3R5',
'PIM1',
'PLA2G4A',
'PLA2G7',
'PLAT',
'PLAUR',
'PLEK',
'PLG',
'PLSCR1',
'PPP2CB',
'PPP4C',
'PRCP',
'PRDM4',
'PREP',
'PRKCD',
'PRSS3',
'PRSS36',
'PSEN1',
'PSMB9',
'RABIF',
'RAF1',
'RASGRP1',
'RBSN',
'RCE1',
'RHOG',
'RNF4',
'S100A12',
'S100A13',
'S100A9',
'SCG3',
'SERPINA1',
'SERPINB2',
'SERPINC1',
'SERPINE1',
'SERPING1',
'SH2B3',
'SIRT6',
'SPOCK2',
'SRC',
'STX4',
'TFPI2',
'TIMP1',
'TIMP2',
'TMPRSS6',
'TNFAIP3',
'USP14',
'USP15',
'USP16',
'USP8',
'VCPIP1',
'WAS',
'XPNPEP1',
'ZEB1',
'ZFPM2'},
'HALLMARK_DNA_REPAIR': {'AAAS',
'ADA',
'ADCY6',
'ADRM1',
'AGO4',
'AK1',
'AK3',
'ALYREF',
'APRT',
'ARL6IP1',
'BCAM',
'BCAP31',
'BOLA2',
'BRF2',
'CANT1',
'CCNO',
'CDA',
'CETN2',
'CLP1',
'CMPK2',
'COX17',
'CSTF3',
'DAD1',
'DCTN4',
'DDB1',
'DDB2',
'DGCR8',
'DGUOK',
'DUT',
'EDF1',
'EIF1B',
'ELL',
'ELOA',
'ERCC1',
'ERCC2',
'ERCC3',
'ERCC4',
'ERCC5',
'ERCC8',
'FEN1',
'GMPR2',
'GPX4',
'GSDME',
'GTF2A2',
'GTF2B',
'GTF2F1',
'GTF2H1',
'GTF2H3',
'GTF2H5',
'GTF3C5',
'GUK1',
'HCLS1',
'HPRT1',
'IMPDH2',
'ITPA',
'LIG1',
'MPC2',
'MPG',
'MRPL40',
'NCBP2',
'NELFB',
'NELFCD',
'NELFE',
'NFX1',
'NME1',
'NME3',
'NME4',
'NPR2',
'NT5C',
'NT5C3A',
'NUDT21',
'NUDT9',
'PCNA',
'PDE4B',
'PDE6G',
'PNP',
'POLA1',
'POLA2',
'POLB',
'POLD1',
'POLD3',
'POLD4',
'POLE4',
'POLH',
'POLL',
'POLR1C',
'POLR1D',
'POLR1H',
'POLR2A',
'POLR2C',
'POLR2D',
'POLR2E',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'POLR2J',
'POLR2K',
'POLR3C',
'POLR3GL',
'POM121',
'PRIM1',
'RAD51',
'RAD52',
'RAE1',
'RALA',
'RBX1',
'REV3L',
'RFC2',
'RFC3',
'RFC4',
'RFC5',
'RNMT',
'RPA2',
'RPA3',
'RRM2B',
'SAC3D1',
'SDCBP',
'SEC61A1',
'SF3A3',
'SMAD5',
'SNAPC4',
'SNAPC5',
'SRSF6',
'SSRP1',
'STX3',
'SUPT4H1',
'SUPT5H',
'SURF1',
'TAF10',
'TAF12',
'TAF13',
'TAF1C',
'TAF6',
'TAF9',
'TARBP2',
'TK2',
'TMED2',
'TP53',
'TSG101',
'TYMS',
'UMPS',
'UPF3B',
'USP11',
'VPS28',
'VPS37B',
'VPS37D',
'XPC',
'ZNF707',
'ZWINT'},
'HALLMARK_E2F_TARGETS': {'AK2',
'ANP32E',
'ASF1A',
'ASF1B',
'ATAD2',
'AURKA',
'AURKB',
'BARD1',
'BIRC5',
'BRCA1',
'BRCA2',
'BRMS1L',
'BUB1B',
'CBX5',
'CCNB2',
'CCNE1',
'CCP110',
'CDC20',
'CDC25A',
'CDC25B',
'CDCA3',
'CDCA8',
'CDK1',
'CDK4',
'CDKN1A',
'CDKN1B',
'CDKN2A',
'CDKN2C',
'CDKN3',
'CENPE',
'CENPM',
'CHEK1',
'CHEK2',
'CIT',
'CKS1B',
'CKS2',
'CNOT9',
'CSE1L',
'CTCF',
'CTPS1',
'DCK',
'DCLRE1B',
'DCTPP1',
'DDX39A',
'DEK',
'DEPDC1',
'DIAPH3',
'DLGAP5',
'DNMT1',
'DONSON',
'DSCC1',
'DUT',
'E2F8',
'EED',
'EIF2S1',
'ESPL1',
'EXOSC8',
'EZH2',
'GINS1',
'GINS3',
'GINS4',
'GSPT1',
'H2AX',
'H2AZ1',
'HELLS',
'HMGA1',
'HMGB2',
'HMGB3',
'HMMR',
'HNRNPD',
'HUS1',
'ILF3',
'ING3',
'IPO7',
'JPT1',
'KIF18B',
'KIF22',
'KIF2C',
'KIF4A',
'KPNA2',
'LBR',
'LIG1',
'LMNB1',
'LUC7L3',
'LYAR',
'MAD2L1',
'MCM2',
'MCM3',
'MCM4',
'MCM5',
'MCM6',
'MCM7',
'MELK',
'MKI67',
'MLH1',
'MMS22L',
'MRE11',
'MSH2',
'MTHFD2',
'MXD3',
'MYBL2',
'MYC',
'NAA38',
'NAP1L1',
'NASP',
'NBN',
'NCAPD2',
'NME1',
'NOLC1',
'NOP56',
'NUDT21',
'NUP107',
'NUP153',
'NUP205',
'ORC2',
'ORC6',
'PA2G4',
'PAICS',
'PAN2',
'PCNA',
'PDS5B',
'PHF5A',
'PLK1',
'PLK4',
'PMS2',
'PNN',
'POLA2',
'POLD1',
'POLD2',
'POLD3',
'POLE',
'POLE4',
'POP7',
'PPM1D',
'PPP1R8',
'PRDX4',
'PRIM2',
'PRKDC',
'PRPS1',
'PSIP1',
'PSMC3IP',
'PTTG1',
'RACGAP1',
'RAD1',
'RAD21',
'RAD50',
'RAD51AP1',
'RAD51C',
'RAN',
'RANBP1',
'RBBP7',
'RFC1',
'RFC2',
'RFC3',
'RNASEH2A',
'RPA1',
'RPA2',
'RPA3',
'RRM2',
'SHMT1',
'SLBP',
'SMC1A',
'SMC3',
'SMC4',
'SMC6',
'SNRPB',
'SPAG5',
'SPC24',
'SPC25',
'SRSF1',
'SRSF2',
'SSRP1',
'STAG1',
'STMN1',
'SUV39H1',
'SYNCRIP',
'TACC3',
'TBRG4',
'TCF19',
'TFRC',
'TIMELESS',
'TIPIN',
'TK1',
'TMPO',
'TOP2A',
'TP53',
'TRA2B',
'TRIP13',
'TUBB',
'TUBG1',
'UBE2S',
'UBE2T',
'UBR7',
'UNG',
'USP1',
'WDR90',
'WEE1',
'XPO1',
'XRCC6',
'ZW10'},
'HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION': {'ABI3BP',
'ACTA2',
'ADAM12',
'ANPEP',
'APLP1',
'AREG',
'BASP1',
'BDNF',
'BGN',
'BMP1',
'CADM1',
'CALD1',
'CALU',
'CAP2',
'CAPG',
'CCN1',
'CCN2',
'CD44',
'CD59',
'CDH11',
'CDH2',
'CDH6',
'COL11A1',
'COL12A1',
'COL16A1',
'COL1A1',
'COL1A2',
'COL3A1',
'COL4A1',
'COL4A2',
'COL5A1',
'COL5A2',
'COL5A3',
'COL6A2',
'COL6A3',
'COL7A1',
'COL8A2',
'COLGALT1',
'COMP',
'COPA',
'CRLF1',
'CTHRC1',
'CXCL1',
'CXCL12',
'CXCL6',
'CXCL8',
'DAB2',
'DCN',
'DKK1',
'DPYSL3',
'DST',
'ECM1',
'ECM2',
'EDIL3',
'EFEMP2',
'ELN',
'EMP3',
'ENO2',
'FAP',
'FAS',
'FBLN1',
'FBLN2',
'FBLN5',
'FBN1',
'FBN2',
'FERMT2',
'FGF2',
'FLNA',
'FMOD',
'FN1',
'FOXC2',
'FSTL1',
'FSTL3',
'FUCA1',
'FZD8',
'GADD45A',
'GADD45B',
'GAS1',
'GEM',
'GJA1',
'GLIPR1',
'GPC1',
'GPX7',
'GREM1',
'HTRA1',
'ID2',
'IGFBP2',
'IGFBP3',
'IGFBP4',
'IL15',
'IL32',
'IL6',
'INHBA',
'ITGA2',
'ITGA5',
'ITGAV',
'ITGB1',
'ITGB3',
'ITGB5',
'JUN',
'LAMA1',
'LAMA2',
'LAMA3',
'LAMC1',
'LAMC2',
'LGALS1',
'LOX',
'LOXL1',
'LOXL2',
'LRP1',
'LRRC15',
'LUM',
'MAGEE1',
'MATN2',
'MATN3',
'MCM7',
'MEST',
'MFAP5',
'MGP',
'MMP1',
'MMP14',
'MMP2',
'MMP3',
'MSX1',
'MXRA5',
'MYL9',
'MYLK',
'NID2',
'NNMT',
'NOTCH2',
'NT5E',
'NTM',
'OXTR',
'P3H1',
'PCOLCE',
'PCOLCE2',
'PDGFRB',
'PDLIM4',
'PFN2',
'PLAUR',
'PLOD1',
'PLOD2',
'PLOD3',
'PMEPA1',
'PMP22',
'POSTN',
'PPIB',
'PRRX1',
'PRSS2',
'PTHLH',
'PTX3',
'PVR',
'QSOX1',
'RGS4',
'RHOB',
'SAT1',
'SCG2',
'SDC1',
'SDC4',
'SERPINE1',
'SERPINE2',
'SERPINH1',
'SFRP1',
'SFRP4',
'SGCB',
'SGCD',
'SGCG',
'SLC6A8',
'SLIT2',
'SLIT3',
'SNAI2',
'SNTB1',
'SPARC',
'SPOCK1',
'SPP1',
'TAGLN',
'TFPI2',
'TGFB1',
'TGFBI',
'TGFBR3',
'TGM2',
'THBS1',
'THBS2',
'THY1',
'TIMP1',
'TIMP3',
'TNC',
'TNFAIP3',
'TNFRSF11B',
'TNFRSF12A',
'TPM1',
'TPM2',
'TPM4',
'VCAM1',
'VCAN',
'VEGFA',
'VEGFC',
'VIM',
'WIPF1',
'WNT5A'},
'HALLMARK_ESTROGEN_RESPONSE_EARLY': {'ABAT',
'ABCA3',
'ABHD2',
'ABLIM1',
'ADCY1',
'ADCY9',
'ADD3',
'AFF1',
'AKAP1',
'ALDH3B1',
'AMFR',
'ANXA9',
'AQP3',
'AR',
'AREG',
'ARL3',
'ASB13',
'B4GALT1',
'BAG1',
'BCL11B',
'BCL2',
'BHLHE40',
'BLVRB',
'CA12',
'CALB2',
'CALCR',
'CANT1',
'CBFA2T3',
'CCN5',
'CCND1',
'CD44',
'CELSR1',
'CELSR2',
'CHPT1',
'CISH',
'CLDN7',
'CLIC3',
'CXCL12',
'CYP26B1',
'DEPTOR',
'DHCR7',
'DHRS2',
'DHRS3',
'DLC1',
'DYNLT3',
'EEIG1',
'EGR3',
'ELF1',
'ELF3',
'ELOVL2',
'ELOVL5',
'ENDOD1',
'ESRP2',
'FARP1',
'FASN',
'FCMR',
'FDFT1',
'FHL2',
'FKBP4',
'FKBP5',
'FLNB',
'FOS',
'FOXC1',
'FRK',
'GAB2',
'GFRA1',
'GJA1',
'GLA',
'GREB1',
'HES1',
'HR',
'HSPB8',
'IGF1R',
'IGFBP4',
'IL17RB',
'IL6ST',
'INHBB',
'INPP5F',
'ISG20L2',
'ITPK1',
'JAK2',
'KAZN',
'KCNK15',
'KCNK5',
'KDM4B',
'KLF10',
'KLF4',
'KLK10',
'KRT13',
'KRT15',
'KRT18',
'KRT19',
'KRT8',
'LAD1',
'LRIG1',
'MAPT',
'MAST4',
'MED13L',
'MED24',
'MICB',
'MINDY1',
'MLPH',
'MPPED2',
'MREG',
'MSMB',
'MUC1',
'MYB',
'MYBBP1A',
'MYBL1',
'MYC',
'MYOF',
'NADSYN1',
'NAV2',
'NBL1',
'NCOR2',
'NHERF1',
'NPY1R',
'NRIP1',
'NXT1',
'OLFM1',
'OLFML3',
'OPN3',
'OVOL2',
'P2RY2',
'PAPSS2',
'PDLIM3',
'PDZK1',
'PEX11A',
'PGR',
'PLAAT3',
'PMAIP1',
'PODXL',
'PPIF',
'PRSS23',
'PTGES',
'RAB17',
'RAB31',
'RAPGEFL1',
'RARA',
'RASGRP1',
'RBBP8',
'REEP1',
'RET',
'RETREG1',
'RHOBTB3',
'RHOD',
'RPS6KA2',
'RRP12',
'SCARB1',
'SCNN1A',
'SEC14L2',
'SEMA3B',
'SFN',
'SH3BP5',
'SIAH2',
'SLC16A1',
'SLC19A2',
'SLC1A1',
'SLC1A4',
'SLC22A5',
'SLC24A3',
'SLC26A2',
'SLC27A2',
'SLC2A1',
'SLC37A1',
'SLC39A6',
'SLC7A2',
'SLC7A5',
'SNX24',
'SOX3',
'STC2',
'SULT2B1',
'SVIL',
'SYBU',
'SYNGR1',
'SYT12',
'TBC1D30',
'TFAP2C',
'TFF1',
'TFF3',
'TGIF2',
'TGM2',
'THSD4',
'TIAM1',
'TIPARP',
'TJP3',
'TMEM164',
'TMPRSS3',
'TOB1',
'TPBG',
'TPD52L1',
'TSKU',
'TTC39A',
'TUBB2B',
'UGCG',
'UNC119',
'WFS1',
'WWC1',
'XBP1',
'ZNF185'},
'HALLMARK_ESTROGEN_RESPONSE_LATE': {'ABCA3',
'ABHD2',
'ACOX2',
'ADD3',
'AFF1',
'AGR2',
'ALDH3A2',
'ALDH3B1',
'AMFR',
'ANXA9',
'AREG',
'ARL3',
'ASCL1',
'ASS1',
'ATP2B4',
'BAG1',
'BATF',
'BCL2',
'BLVRB',
'BTG3',
'CA12',
'CA2',
'CACNA2D2',
'CALCR',
'CAV1',
'CCN5',
'CCNA1',
'CCND1',
'CD44',
'CD9',
'CDC20',
'CDC6',
'CDH1',
'CELSR2',
'CHPT1',
'CHST8',
'CISH',
'CKB',
'CLIC3',
'COX6C',
'CPE',
'CXCL12',
'CXCL14',
'CYP26B1',
'CYP4F11',
'DCXR',
'DHCR7',
'DHRS2',
'DLG5',
'DNAJC1',
'DNAJC12',
'DUSP2',
'DYNLT3',
'EEIG1',
'EGR3',
'ELOVL5',
'EMP2',
'ETFB',
'FABP5',
'FARP1',
'FDFT1',
'FGFR3',
'FKBP4',
'FKBP5',
'FLNB',
'FOS',
'FOXC1',
'FRK',
'GAL',
'GALE',
'GFUS',
'GINS2',
'GJB3',
'GLA',
'GPER1',
'HMGCS2',
'HOMER2',
'HPRT1',
'HR',
'HSPA4L',
'HSPB8',
'ID2',
'IDH2',
'IGFBP4',
'IGSF1',
'IL17RB',
'IL6ST',
'IMPA2',
'ISG20',
'ITPK1',
'JAK1',
'JAK2',
'KCNK5',
'KIF20A',
'KLF4',
'KLK10',
'KLK11',
'KRT13',
'KRT19',
'LAMC2',
'LARGE1',
'LLGL2',
'LSR',
'LTF',
'MAPK13',
'MAPT',
'MDK',
'MEST',
'METTL3',
'MICB',
'MOCS2',
'MYB',
'MYOF',
'NAB2',
'NBL1',
'NCOR2',
'NHERF1',
'NMU',
'NPY1R',
'NRIP1',
'NXT1',
'OLFM1',
'OPN3',
'OVOL2',
'PAPSS2',
'PCP4',
'PDCD4',
'PDLIM3',
'PDZK1',
'PERP',
'PGR',
'PKP3',
'PLAAT3',
'PLAC1',
'PLK4',
'PLXNB1',
'PPIF',
'PRKAR2B',
'PRLR',
'PRSS23',
'PTGER3',
'PTGES',
'PTPN6',
'RAB31',
'RABEP1',
'RAPGEFL1',
'RBBP8',
'RET',
'RNASEH2A',
'RPS6KA2',
'S100A9',
'SCARB1',
'SCNN1A',
'SCUBE2',
'SEMA3B',
'SERPINA1',
'SERPINA3',
'SERPINA5',
'SFN',
'SGK1',
'SIAH2',
'SLC16A1',
'SLC1A4',
'SLC22A5',
'SLC24A3',
'SLC26A2',
'SLC27A2',
'SLC29A1',
'SLC2A8',
'SLC7A5',
'SNX10',
'SORD',
'SOX3',
'ST14',
'ST6GALNAC2',
'STIL',
'SULT2B1',
'TFAP2C',
'TFF1',
'TFF3',
'TFPI2',
'TH',
'TIAM1',
'TJP3',
'TMPRSS3',
'TNNC1',
'TOB1',
'TOP2A',
'TPBG',
'TPD52L1',
'TPSAB1',
'TRIM29',
'TSPAN13',
'TST',
'UGDH',
'UNC13B',
'WFS1',
'XBP1',
'XRCC3',
'ZFP36'},
'HALLMARK_FATTY_ACID_METABOLISM': {'AADAT',
'ACAA1',
'ACAA2',
'ACADL',
'ACADM',
'ACADS',
'ACADVL',
'ACAT2',
'ACO2',
'ACOT2',
'ACOT8',
'ACOX1',
'ACSL1',
'ACSL4',
'ACSL5',
'ACSM3',
'ACSS1',
'ADH1C',
'ADH7',
'ADIPOR2',
'ADSL',
'ALAD',
'ALDH1A1',
'ALDH3A1',
'ALDH3A2',
'ALDH9A1',
'ALDOA',
'AOC3',
'APEX1',
'AQP7',
'AUH',
'BCKDHB',
'BLVRA',
'BMPR1B',
'BPHL',
'CA2',
'CA4',
'CA6',
'CBR1',
'CBR3',
'CD1D',
'CD36',
'CEL',
'CIDEA',
'CPOX',
'CPT1A',
'CPT2',
'CRAT',
'CRYZ',
'CYP1A1',
'CYP4A11',
'CYP4A22',
'D2HGDH',
'DECR1',
'DHCR24',
'DLD',
'DLST',
'ECH1',
'ECHS1',
'ECI1',
'ECI2',
'EHHADH',
'ELOVL5',
'ENO2',
'ENO3',
'EPHX1',
'ERP29',
'ETFDH',
'FABP1',
'FABP2',
'FASN',
'FH',
'FMO1',
'G0S2',
'GABARAPL1',
'GAD2',
'GAPDHS',
'GCDH',
'GLUL',
'GPD1',
'GPD2',
'GRHPR',
'GSTZ1',
'H2AZ1',
'HADH',
'HADHB',
'HAO2',
'HCCS',
'HIBCH',
'HMGCL',
'HMGCS1',
'HMGCS2',
'HPGD',
'HSD17B10',
'HSD17B11',
'HSD17B4',
'HSD17B7',
'HSDL2',
'HSP90AA1',
'HSPH1',
'IDH1',
'IDH3B',
'IDH3G',
'IDI1',
'IL4I1',
'INMT',
'KMT5A',
'LDHA',
'LGALS1',
'LTC4S',
'MAOA',
'MCEE',
'MDH1',
'MDH2',
'ME1',
'METAP1',
'MGLL',
'MIF',
'MIX23',
'MLYCD',
'NBN',
'NCAPH2',
'NSDHL',
'NTHL1',
'ODC1',
'OSTC',
'PCBD1',
'PDHA1',
'PDHB',
'PPARA',
'PRDX6',
'PSME1',
'PTPRG',
'PTS',
'RAP1GDS1',
'RDH11',
'RDH16',
'REEP6',
'RETSAT',
'S100A10',
'SDHA',
'SDHC',
'SDHD',
'SERINC1',
'SLC22A5',
'SMS',
'SUCLA2',
'SUCLG1',
'SUCLG2',
'TDO2',
'TP53INP2',
'UBE2L6',
'UGDH',
'UROD',
'UROS',
'VNN1',
'XIST',
'YWHAH'},
'HALLMARK_G2M_CHECKPOINT': {'ABL1',
'AMD1',
'ARID4A',
'ATF5',
'ATRX',
'AURKA',
'AURKB',
'BARD1',
'BCL3',
'BIRC5',
'BRCA2',
'BUB1',
'BUB3',
'CASP8AP2',
'CBX1',
'CCNA2',
'CCNB2',
'CCND1',
'CCNF',
'CCNT1',
'CDC20',
'CDC25A',
'CDC25B',
'CDC27',
'CDC45',
'CDC6',
'CDC7',
'CDK1',
'CDK4',
'CDKN1B',
'CDKN2C',
'CDKN3',
'CENPA',
'CENPE',
'CENPF',
'CHAF1A',
'CHEK1',
'CHMP1A',
'CKS1B',
'CKS2',
'CTCF',
'CUL1',
'CUL3',
'CUL4A',
'CUL5',
'DBF4',
'DDX39A',
'DKC1',
'DMD',
'DR1',
'DTYMK',
'E2F1',
'E2F2',
'E2F3',
'E2F4',
'EFNA5',
'EGF',
'ESPL1',
'EWSR1',
'EXO1',
'EZH2',
'FANCC',
'FBXO5',
'FOXN3',
'G3BP1',
'GINS2',
'GSPT1',
'H2AX',
'H2AZ1',
'H2AZ2',
'H2BC12',
'HIF1A',
'HIRA',
'HMGA1',
'HMGB3',
'HMGN2',
'HMMR',
'HNRNPD',
'HNRNPU',
'HOXC10',
'HSPA8',
'HUS1',
'ILF3',
'INCENP',
'JPT1',
'KATNA1',
'KIF11',
'KIF15',
'KIF20B',
'KIF22',
'KIF23',
'KIF2C',
'KIF4A',
'KIF5B',
'KMT5A',
'KNL1',
'KPNA2',
'KPNB1',
'LBR',
'LIG3',
'LMNB1',
'MAD2L1',
'MAP3K20',
'MAPK14',
'MARCKS',
'MCM2',
'MCM3',
'MCM5',
'MCM6',
'MEIS1',
'MEIS2',
'MKI67',
'MNAT1',
'MT2A',
'MTF2',
'MYBL2',
'MYC',
'NASP',
'NCL',
'NDC80',
'NEK2',
'NOLC1',
'NOTCH2',
'NSD2',
'NUMA1',
'NUP50',
'NUP98',
'NUSAP1',
'ODC1',
'ODF2',
'ORC5',
'ORC6',
'PAFAH1B1',
'PBK',
'PDS5B',
'PLK1',
'PLK4',
'PML',
'POLA2',
'POLE',
'POLQ',
'PRC1',
'PRIM2',
'PRMT5',
'PRPF4B',
'PTTG1',
'PTTG3P',
'PURA',
'RACGAP1',
'RAD21',
'RAD23B',
'RAD54L',
'RASAL2',
'RBL1',
'RBM14',
'RPA2',
'RPS6KA5',
'SAP30',
'SFPQ',
'SLC12A2',
'SLC38A1',
'SLC7A1',
'SLC7A5',
'SMAD3',
'SMARCC1',
'SMC1A',
'SMC2',
'SMC4',
'SNRPD1',
'SQLE',
'SRSF1',
'SRSF10',
'SRSF2',
'SS18',
'STAG1',
'STIL',
'STMN1',
'SUV39H1',
'SYNCRIP',
'TACC3',
'TENT4A',
'TFDP1',
'TGFB1',
'TLE3',
'TMPO',
'TNPO2',
'TOP1',
'TOP2A',
'TPX2',
'TRA2B',
'TRAIP',
'TROAP',
'TTK',
'UBE2C',
'UBE2S',
'UCK2',
'UPF1',
'WRN',
'XPO1',
'YTHDC1'},
'HALLMARK_GLYCOLYSIS': {'ABCB6',
'ADORA2B',
'AGL',
'AGRN',
'AK3',
'AK4',
'AKR1A1',
'ALDH7A1',
'ALDH9A1',
'ALDOA',
'ALDOB',
'ALG1',
'ANG',
'ANGPTL4',
'ANKZF1',
'ARPP19',
'ARTN',
'AURKA',
'B3GALT6',
'B3GAT1',
'B3GAT3',
'B3GNT3',
'B4GALT1',
'B4GALT2',
'B4GALT4',
'B4GALT7',
'BIK',
'BPNT1',
'CACNA1H',
'CAPN5',
'CASP6',
'CD44',
'CDK1',
'CENPA',
'CHPF',
'CHPF2',
'CHST1',
'CHST12',
'CHST2',
'CHST4',
'CHST6',
'CITED2',
'CLDN3',
'CLDN9',
'CLN6',
'COG2',
'COL5A1',
'COPB2',
'CTH',
'CXCR4',
'CYB5A',
'DCN',
'DDIT4',
'DEPDC1',
'DLD',
'DPYSL4',
'DSC2',
'ECD',
'EFNA3',
'EGFR',
'EGLN3',
'ELF3',
'ENO1',
'ENO2',
'ERO1A',
'EXT1',
'EXT2',
'FAM162A',
'FBP2',
'FKBP4',
'FUT8',
'G6PD',
'GAL3ST1',
'GALE',
'GALK1',
'GALK2',
'GAPDHS',
'GCLC',
'GFPT1',
'GFUS',
'GLCE',
'GLRX',
'GMPPA',
'GMPPB',
'GNE',
'GNPDA1',
'GOT1',
'GOT2',
'GPC1',
'GPC3',
'GPC4',
'GPR87',
'GUSB',
'GYS1',
'GYS2',
'HAX1',
'HDLBP',
'HK2',
'HMMR',
'HOMER1',
'HS2ST1',
'HS6ST2',
'HSPA5',
'IDH1',
'IDUA',
'IER3',
'IGFBP3',
'IL13RA1',
'IRS2',
'ISG20',
'KDELR3',
'KIF20A',
'KIF2A',
'LCT',
'LDHA',
'LDHC',
'LHPP',
'LHX9',
'MDH1',
'MDH2',
'ME1',
'ME2',
'MED24',
'MERTK',
'MET',
'MIF',
'MIOX',
'MPI',
'MXI1',
'NANP',
'NASP',
'NDST3',
'NDUFV3',
'NOL3',
'NSDHL',
'NT5E',
'P4HA1',
'P4HA2',
'PAM',
'PAXIP1',
'PC',
'PDK3',
'PFKFB1',
'PFKP',
'PGAM1',
'PGAM2',
'PGK1',
'PGLS',
'PGM2',
'PHKA2',
'PKM',
'PKP2',
'PLOD1',
'PLOD2',
'PMM2',
'POLR3K',
'PPFIA4',
'PPIA',
'PPP2CB',
'PRPS1',
'PSMC4',
'PYGB',
'PYGL',
'QSOX1',
'RARS1',
'RBCK1',
'RPE',
'RRAGD',
'SAP30',
'SDC1',
'SDC2',
'SDC3',
'SDHC',
'SLC16A3',
'SLC25A10',
'SLC25A13',
'SLC35A3',
'SLC37A4',
'SOD1',
'SOX9',
'SPAG4',
'SRD5A3',
'STC1',
'STC2',
'STMN1',
'TALDO1',
'TFF3',
'TGFA',
'TGFBI',
'TKTL1',
'TPBG',
'TPI1',
'TPST1',
'TXN',
'UGP2',
'VCAN',
'VEGFA',
'VLDLR',
'XYLT2',
'ZNF292'},
'HALLMARK_HEDGEHOG_SIGNALING': {'ACHE',
'ADGRG1',
'AMOT',
'CDK5R1',
'CDK6',
'CELSR1',
'CNTFR',
'CRMP1',
'DPYSL2',
'ETS2',
'GLI1',
'HEY1',
'HEY2',
'L1CAM',
'LDB1',
'MYH9',
'NF1',
'NKX6-1',
'NRCAM',
'NRP1',
'NRP2',
'OPHN1',
'PLG',
'PML',
'PTCH1',
'RASA1',
'RTN1',
'SCG2',
'SHH',
'SLIT1',
'THY1',
'TLE1',
'TLE3',
'UNC5C',
'VEGFA',
'VLDLR'},
'HALLMARK_HEME_METABOLISM': {'ABCB6',
'ABCG2',
'ACKR1',
'ACP5',
'ACSL6',
'ADD1',
'ADD2',
'ADIPOR1',
'AGPAT4',
'AHSP',
'ALAD',
'ALAS2',
'ALDH1L1',
'ALDH6A1',
'ANK1',
'AQP3',
'ARHGEF12',
'ARL2BP',
'ASNS',
'ATG4A',
'ATP6V0A1',
'BACH1',
'BCAM',
'BLVRA',
'BLVRB',
'BMP2K',
'BNIP3L',
'BPGM',
'BSG',
'BTG2',
'BTRC',
'C3',
'CA1',
'CA2',
'CAST',
'CAT',
'CCDC28A',
'CCND3',
'CDC27',
'CDR2',
'CIR1',
'CLCN3',
'CLIC2',
'CPOX',
'CROCCP2',
'CTNS',
'CTSB',
'CTSE',
'DAAM1',
'DCAF10',
'DCAF11',
'DCUN1D1',
'DMTN',
'E2F2',
'EIF2AK1',
'ELL2',
'ENDOD1',
'EPB41',
'EPB42',
'EPOR',
'ERMAP',
'EZH1',
'FBXO34',
'FBXO7',
'FBXO9',
'FECH',
'FN3K',
'FOXJ2',
'FOXO3',
'FTCD',
'GAPVD1',
'GATA1',
'GCLC',
'GCLM',
'GDE1',
'GLRX5',
'GMPS',
'GYPA',
'GYPB',
'GYPC',
'GYPE',
'H1-0',
'H4C3',
'HAGH',
'HBB',
'HBBP1',
'HBD',
'HBQ1',
'HBZ',
'HDGF',
'HEBP1',
'HMBS',
'HTATIP2',
'HTRA2',
'ICAM4',
'IGSF3',
'ISCA1',
'KAT2B',
'KDM7A',
'KEL',
'KHNYN',
'KLF1',
'KLF3',
'LAMP2',
'LMO2',
'LPIN2',
'LRP10',
'MAP2K3',
'MARCHF2',
'MARCHF8',
'MARK3',
'MBOAT2',
'MFHAS1',
'MGST3',
'MINPP1',
'MKRN1',
'MOCOS',
'MOSPD1',
'MPP1',
'MXI1',
'MYL4',
'NARF',
'NCOA4',
'NEK7',
'NFE2',
'NFE2L1',
'NNT',
'NR3C1',
'NUDT4',
'OPTN',
'OSBP2',
'P4HA2',
'PC',
'PDZK1IP1',
'PGLS',
'PICALM',
'PIGQ',
'PPOX',
'PPP2R5B',
'PRDX2',
'PSMD9',
'RAD23A',
'RANBP10',
'RAP1GAP',
'RBM38',
'RBM5',
'RCL1',
'RHAG',
'RHCE',
'RHD',
'RIOK3',
'RNF123',
'RNF19A',
'SDCBP',
'SEC14L1',
'SELENBP1',
'SIDT2',
'SLC10A3',
'SLC11A2',
'SLC22A4',
'SLC25A37',
'SLC25A38',
'SLC2A1',
'SLC30A1',
'SLC30A10',
'SLC4A1',
'SLC66A2',
'SLC6A8',
'SLC6A9',
'SLC7A11',
'SMOX',
'SNCA',
'SPTA1',
'SPTB',
'SYNJ1',
'TAL1',
'TCEA1',
'TENT5C',
'TFDP2',
'TFRC',
'TMCC2',
'TMEM9B',
'TNRC6B',
'TNS1',
'TOP1',
'TRAK2',
'TRIM10',
'TRIM58',
'TSPAN5',
'TSPO2',
'TYR',
'UBAC1',
'UCP2',
'UROD',
'UROS',
'USP15',
'VEZF1',
'XK',
'XPO7',
'YPEL5'},
'HALLMARK_HYPOXIA': {'ACKR3',
'ADM',
'ADORA2B',
'AK4',
'AKAP12',
'ALDOA',
'ALDOB',
'ALDOC',
'AMPD3',
'ANGPTL4',
'ANKZF1',
'ANXA2',
'ATF3',
'ATP7A',
'B3GALT6',
'B4GALNT2',
'BCAN',
'BCL2',
'BGN',
'BHLHE40',
'BNIP3L',
'BRS3',
'BTG1',
'CA12',
'CASP6',
'CAV1',
'CAVIN1',
'CAVIN3',
'CCN1',
'CCN2',
'CCN5',
'CCNG2',
'CDKN1A',
'CDKN1B',
'CDKN1C',
'CHST2',
'CHST3',
'CITED2',
'COL5A1',
'CP',
'CSRP2',
'CXCR4',
'DCN',
'DDIT3',
'DDIT4',
'DPYSL4',
'DTNA',
'DUSP1',
'EDN2',
'EFNA1',
'EFNA3',
'EGFR',
'ENO1',
'ENO2',
'ENO3',
'ERO1A',
'ERRFI1',
'ETS1',
'EXT1',
'F3',
'FAM162A',
'FBP1',
'FOS',
'FOSL2',
'FOXO3',
'GAA',
'GALK1',
'GAPDH',
'GAPDHS',
'GBE1',
'GCK',
'GCNT2',
'GLRX',
'GPC1',
'GPC3',
'GPC4',
'GPI',
'GRHPR',
'GYS1',
'HAS1',
'HDLBP',
'HEXA',
'HK1',
'HK2',
'HMOX1',
'HOXB9',
'HS3ST1',
'HSPA5',
'IDS',
'IER3',
'IGFBP1',
'IGFBP3',
'IL6',
'ILVBL',
'INHA',
'IRS2',
'ISG20',
'JMJD6',
'JUN',
'KDELR3',
'KDM3A',
'KIF5A',
'KLF6',
'KLF7',
'KLHL24',
'LALBA',
'LARGE1',
'LDHA',
'LDHC',
'LOX',
'LXN',
'MAFF',
'MAP3K1',
'MIF',
'MT1E',
'MT2A',
'MXI1',
'MYH9',
'NAGK',
'NCAN',
'NDRG1',
'NDST1',
'NDST2',
'NEDD4L',
'NFIL3',
'NOCT',
'NR3C1',
'P4HA1',
'P4HA2',
'PAM',
'PCK1',
'PDGFB',
'PDK1',
'PDK3',
'PFKFB3',
'PFKL',
'PFKP',
'PGAM2',
'PGF',
'PGK1',
'PGM1',
'PGM2',
'PHKG1',
'PIM1',
'PKLR',
'PKP1',
'PLAC8',
'PLAUR',
'PLIN2',
'PNRC1',
'PPARGC1A',
'PPFIA4',
'PPP1R15A',
'PPP1R3C',
'PRDX5',
'PRKCA',
'PYGM',
'RBPJ',
'RORA',
'RRAGD',
'S100A4',
'SAP30',
'SCARB1',
'SDC2',
'SDC3',
'SDC4',
'SELENBP1',
'SERPINE1',
'SIAH2',
'SLC25A1',
'SLC2A1',
'SLC2A3',
'SLC2A5',
'SLC37A4',
'SLC6A6',
'SRPX',
'STBD1',
'STC1',
'STC2',
'SULT2B1',
'TES',
'TGFB3',
'TGFBI',
'TGM2',
'TIPARP',
'TKTL1',
'TMEM45A',
'TNFAIP3',
'TPBG',
'TPD52',
'TPI1',
'TPST2',
'UGP2',
'VEGFA',
'VHL',
'VLDLR',
'WSB1',
'XPNPEP1',
'ZFP36',
'ZNF292'},
'HALLMARK_IL2_STAT5_SIGNALING': {'ABCB1',
'ADAM19',
'AGER',
'AHCY',
'AHNAK',
'AHR',
'ALCAM',
'AMACR',
'ANXA4',
'APLP1',
'ARL4A',
'BATF',
'BATF3',
'BCL2',
'BCL2L1',
'BHLHE40',
'BMP2',
'BMPR2',
'CA2',
'CAPG',
'CAPN3',
'CASP3',
'CCND2',
'CCND3',
'CCNE1',
'CCR4',
'CD44',
'CD48',
'CD79B',
'CD81',
'CD83',
'CD86',
'CDC42SE2',
'CDC6',
'CDCP1',
'CDKN1C',
'CISH',
'CKAP4',
'COCH',
'COL6A1',
'CSF1',
'CSF2',
'CST7',
'CTLA4',
'CTSZ',
'CXCL10',
'CYFIP1',
'DCPS',
'DENND5A',
'DHRS3',
'DRC1',
'ECM1',
'EEF1AKMT1',
'EMP1',
'ENO3',
'ENPP1',
'EOMES',
'ETFBKMT',
'ETV4',
'F2RL2',
'FAH',
'FGL2',
'FLT3LG',
'FURIN',
'GABARAPL1',
'GADD45B',
'GALM',
'GATA1',
'GBP4',
'GLIPR2',
'GPR65',
'GPR83',
'GPX4',
'GSTO1',
'GUCY1B1',
'HIPK2',
'HK2',
'HOPX',
'HUWE1',
'HYCC2',
'ICOS',
'IFITM3',
'IFNGR1',
'IGF1R',
'IGF2R',
'IKZF2',
'IKZF4',
'IL10',
'IL10RA',
'IL13',
'IL18R1',
'IL1R2',
'IL1RL1',
'IL2RA',
'IL2RB',
'IL3RA',
'IL4R',
'IRF4',
'IRF6',
'IRF8',
'ITGA6',
'ITGAE',
'ITGAV',
'ITIH5',
'KLF6',
'LCLAT1',
'LIF',
'LRIG1',
'LRRC8C',
'LTB',
'MAFF',
'MAP3K8',
'MAP6',
'MAPKAPK2',
'MUC1',
'MXD1',
'MYC',
'MYO1C',
'MYO1E',
'NCOA3',
'NCS1',
'NDRG1',
'NFIL3',
'NFKBIZ',
'NOP2',
'NRP1',
'NT5E',
'ODC1',
'P2RX4',
'P4HA1',
'PDCD2L',
'PENK',
'PHLDA1',
'PHTF2',
'PIM1',
'PLAGL1',
'PLEC',
'PLIN2',
'PLPP1',
'PLSCR1',
'PNP',
'POU2F1',
'PRAF2',
'PRKCH',
'PRNP',
'PTCH1',
'PTGER2',
'PTH1R',
'PTRH2',
'PUS1',
'RABGAP1L',
'RGS16',
'RHOB',
'RHOH',
'RNH1',
'RORA',
'RRAGD',
'S100A1',
'SCN9A',
'SELL',
'SELP',
'SERPINB6',
'SERPINC1',
'SH3BGRL2',
'SHE',
'SLC1A5',
'SLC29A2',
'SLC2A3',
'SLC39A8',
'SMPDL3A',
'SNX14',
'SNX9',
'SOCS1',
'SOCS2',
'SPP1',
'SPRED2',
'SPRY4',
'ST3GAL4',
'SWAP70',
'SYNGR2',
'SYT11',
'TGM2',
'TIAM1',
'TLR7',
'TNFRSF18',
'TNFRSF1B',
'TNFRSF21',
'TNFRSF4',
'TNFRSF8',
'TNFRSF9',
'TNFSF10',
'TNFSF11',
'TRAF1',
'TTC39B',
'TWSG1',
'UCK2',
'UMPS',
'WLS',
'XBP1'},
'HALLMARK_IL6_JAK_STAT3_SIGNALING': {'A2M',
'ACVR1B',
'ACVRL1',
'BAK1',
'CBL',
'CCL7',
'CCR1',
'CD14',
'CD36',
'CD38',
'CD44',
'CD9',
'CNTFR',
'CRLF2',
'CSF1',
'CSF2',
'CSF2RA',
'CSF2RB',
'CSF3R',
'CXCL1',
'CXCL10',
'CXCL11',
'CXCL13',
'CXCL3',
'CXCL9',
'DNTT',
'EBI3',
'FAS',
'GRB2',
'HAX1',
'HMOX1',
'IFNAR1',
'IFNGR1',
'IFNGR2',
'IL10RB',
'IL12RB1',
'IL13RA1',
'IL15RA',
'IL17RA',
'IL17RB',
'IL18R1',
'IL1B',
'IL1R1',
'IL1R2',
'IL2RA',
'IL2RG',
'IL3RA',
'IL4R',
'IL6',
'IL6ST',
'IL7',
'IL9R',
'INHBE',
'IRF1',
'IRF9',
'ITGA4',
'ITGB3',
'JUN',
'LEPR',
'LTB',
'LTBR',
'MAP3K8',
'MYD88',
'OSMR',
'PDGFC',
'PF4',
'PIK3R5',
'PIM1',
'PLA2G2A',
'PTPN1',
'PTPN11',
'PTPN2',
'REG1A',
'SOCS1',
'SOCS3',
'STAM2',
'STAT1',
'STAT2',
'STAT3',
'TGFB1',
'TLR2',
'TNF',
'TNFRSF12A',
'TNFRSF1A',
'TNFRSF1B',
'TNFRSF21',
'TYK2'},
'HALLMARK_INFLAMMATORY_RESPONSE': {'ABCA1',
'ABI1',
'ACVR1B',
'ACVR2A',
'ADGRE1',
'ADM',
'ADORA2B',
'ADRM1',
'AHR',
'APLNR',
'AQP9',
'ATP2A2',
'ATP2B1',
'ATP2C1',
'AXL',
'BDKRB1',
'BEST1',
'BST2',
'BTG2',
'C3AR1',
'C5AR1',
'CALCRL',
'CCL17',
'CCL2',
'CCL20',
'CCL22',
'CCL24',
'CCL5',
'CCL7',
'CCR7',
'CCRL2',
'CD14',
'CD40',
'CD48',
'CD55',
'CD69',
'CD70',
'CD82',
'CDKN1A',
'CHST2',
'CLEC5A',
'CMKLR1',
'CSF1',
'CSF3',
'CSF3R',
'CX3CL1',
'CXCL10',
'CXCL11',
'CXCL6',
'CXCL8',
'CXCL9',
'CXCR6',
'CYBB',
'DCBLD2',
'EBI3',
'EDN1',
'EIF2AK2',
'EMP3',
'EREG',
'F3',
'FFAR2',
'FPR1',
'FZD5',
'GABBR1',
'GCH1',
'GNA15',
'GNAI3',
'GP1BA',
'GPC3',
'GPR132',
'GPR183',
'HAS2',
'HBEGF',
'HIF1A',
'HPN',
'HRH1',
'ICAM1',
'ICAM4',
'ICOSLG',
'IFITM1',
'IFNAR1',
'IFNGR2',
'IL10',
'IL10RA',
'IL12B',
'IL15',
'IL15RA',
'IL18',
'IL18R1',
'IL18RAP',
'IL1A',
'IL1B',
'IL1R1',
'IL2RB',
'IL4R',
'IL6',
'IL7R',
'INHBA',
'IRAK2',
'IRF1',
'IRF7',
'ITGA5',
'ITGB3',
'ITGB8',
'KCNA3',
'KCNJ2',
'KCNMB2',
'KIF1B',
'KLF6',
'LAMP3',
'LCK',
'LCP2',
'LDLR',
'LIF',
'LPAR1',
'LTA',
'LY6E',
'LYN',
'MARCO',
'MEFV',
'MEP1A',
'MET',
'MMP14',
'MSR1',
'MXD1',
'MYC',
'NAMPT',
'NDP',
'NFKB1',
'NFKBIA',
'NLRP3',
'NMI',
'NMUR1',
'NOD2',
'NPFFR2',
'OLR1',
'OPRK1',
'OSM',
'OSMR',
'P2RX4',
'P2RX7',
'P2RY2',
'PCDH7',
'PDE4B',
'PDPN',
'PIK3R5',
'PLAUR',
'PROK2',
'PSEN1',
'PTAFR',
'PTGER2',
'PTGER4',
'PTGIR',
'PTPRE',
'PVR',
'RAF1',
'RASGRP1',
'RELA',
'RGS1',
'RGS16',
'RHOG',
'RIPK2',
'RNF144B',
'ROS1',
'RTP4',
'SCARF1',
'SCN1B',
'SELE',
'SELENOS',
'SELL',
'SEMA4D',
'SERPINE1',
'SGMS2',
'SLAMF1',
'SLC11A2',
'SLC1A2',
'SLC28A2',
'SLC31A1',
'SLC31A2',
'SLC4A4',
'SLC7A1',
'SLC7A2',
'SPHK1',
'SRI',
'STAB1',
'TACR1',
'TACR3',
'TAPBP',
'TIMP1',
'TLR1',
'TLR2',
'TLR3',
'TNFAIP6',
'TNFRSF1B',
'TNFRSF9',
'TNFSF10',
'TNFSF15',
'TNFSF9',
'TPBG',
'VIP'},
'HALLMARK_INTERFERON_ALPHA_RESPONSE': {'ADAR',
'B2M',
'BATF2',
'BST2',
'C1S',
'CASP1',
'CASP8',
'CCRL2',
'CD47',
'CD74',
'CMPK2',
'CMTR1',
'CNP',
'CSF1',
'CXCL10',
'CXCL11',
'DDX60',
'DHX58',
'EIF2AK2',
'ELF1',
'EPSTI1',
'GBP2',
'GBP4',
'GMPR',
'HELZ2',
'HERC6',
'HLA-C',
'IFI27',
'IFI30',
'IFI35',
'IFI44',
'IFI44L',
'IFIH1',
'IFIT2',
'IFIT3',
'IFITM1',
'IFITM2',
'IFITM3',
'IL15',
'IL4R',
'IL7',
'IRF1',
'IRF2',
'IRF7',
'IRF9',
'ISG15',
'ISG20',
'LAMP3',
'LAP3',
'LGALS3BP',
'LPAR6',
'LY6E',
'MOV10',
'MVB12A',
'MX1',
'NCOA7',
'NMI',
'NUB1',
'OAS1',
'OASL',
'OGFR',
'PARP12',
'PARP14',
'PARP9',
'PLSCR1',
'PNPT1',
'PROCR',
'PSMA3',
'PSMB8',
'PSMB9',
'PSME1',
'PSME2',
'RIPK2',
'RNF31',
'RSAD2',
'RTP4',
'SAMD9',
'SAMD9L',
'SELL',
'SLC25A28',
'SP110',
'STAT2',
'TAP1',
'TDRD7',
'TENT5A',
'TMEM140',
'TRAFD1',
'TRIM14',
'TRIM21',
'TRIM25',
'TRIM26',
'TRIM5',
'TXNIP',
'UBA7',
'UBE2L6',
'USP18',
'WARS1'},
'HALLMARK_INTERFERON_GAMMA_RESPONSE': {'ADAR',
'APOL6',
'ARID5B',
'ARL4A',
'AUTS2',
'B2M',
'BANK1',
'BATF2',
'BPGM',
'BST2',
'BTG1',
'C1R',
'C1S',
'CASP1',
'CASP3',
'CASP4',
'CASP7',
'CASP8',
'CCL2',
'CCL5',
'CCL7',
'CD274',
'CD38',
'CD40',
'CD69',
'CD74',
'CD86',
'CDKN1A',
'CFB',
'CFH',
'CIITA',
'CMKLR1',
'CMPK2',
'CMTR1',
'CSF2RB',
'CXCL10',
'CXCL11',
'CXCL9',
'DDX60',
'DHX58',
'EIF2AK2',
'EIF4E3',
'EPSTI1',
'FAS',
'FCGR1A',
'FGL2',
'FPR1',
'GBP4',
'GBP6',
'GCH1',
'GPR18',
'GZMA',
'HELZ2',
'HERC6',
'HIF1A',
'HLA-A',
'HLA-B',
'HLA-DMA',
'HLA-DQA1',
'HLA-DRB1',
'HLA-G',
'ICAM1',
'IDO1',
'IFI27',
'IFI30',
'IFI35',
'IFI44',
'IFI44L',
'IFIH1',
'IFIT1',
'IFIT2',
'IFIT3',
'IFITM2',
'IFITM3',
'IFNAR2',
'IL10RA',
'IL15',
'IL15RA',
'IL18BP',
'IL2RB',
'IL4R',
'IL6',
'IL7',
'IRF1',
'IRF2',
'IRF4',
'IRF5',
'IRF7',
'IRF8',
'IRF9',
'ISG15',
'ISG20',
'ISOC1',
'ITGB7',
'JAK2',
'KLRK1',
'LAP3',
'LATS2',
'LCP2',
'LGALS3BP',
'LY6E',
'LYSMD2',
'MARCHF1',
'METTL7B',
'MT2A',
'MTHFD2',
'MVP',
'MX1',
'MX2',
'MYD88',
'NAMPT',
'NCOA3',
'NFKB1',
'NFKBIA',
'NLRC5',
'NMI',
'NOD1',
'NUP93',
'OAS2',
'OAS3',
'OASL',
'OGFR',
'P2RY14',
'PARP12',
'PARP14',
'PDE4B',
'PELI1',
'PFKP',
'PIM1',
'PLA2G4A',
'PLSCR1',
'PML',
'PNP',
'PNPT1',
'PSMA2',
'PSMA3',
'PSMB10',
'PSMB2',
'PSMB8',
'PSMB9',
'PSME1',
'PSME2',
'PTGS2',
'PTPN1',
'PTPN2',
'PTPN6',
'RAPGEF6',
'RBCK1',
'RIGI',
'RIPK1',
'RIPK2',
'RNF213',
'RNF31',
'RSAD2',
'RTP4',
'SAMD9L',
'SAMHD1',
'SECTM1',
'SELP',
'SERPING1',
'SLAMF7',
'SLC25A28',
'SOCS1',
'SOCS3',
'SOD2',
'SP110',
'SPPL2A',
'SRI',
'SSPN',
'ST3GAL5',
'ST8SIA4',
'STAT1',
'STAT2',
'STAT3',
'STAT4',
'TAP1',
'TAPBP',
'TDRD7',
'TNFAIP2',
'TNFAIP3',
'TNFAIP6',
'TNFSF10',
'TOR1B',
'TRAFD1',
'TRIM14',
'TRIM21',
'TRIM25',
'TRIM26',
'TXNIP',
'UBE2L6',
'UPP1',
'USP18',
'VAMP5',
'VAMP8',
'VCAM1',
'WARS1',
'XAF1',
'XCL1',
'ZBP1',
'ZNFX1'},
'HALLMARK_KRAS_SIGNALING_DN': {'ABCB11',
'ABCG4',
'ACTC1',
'ADRA2C',
'AKR1B10',
'ALOX12B',
'AMBN',
'ARHGDIG',
'ARPP21',
'ASB7',
'ATP4A',
'ATP6V1B1',
'BARD1',
'BMPR1B',
'BRDT',
'BTG2',
'C5',
'CACNA1F',
'CACNG1',
'CALCB',
'CALML5',
'CAMK1D',
'CAPN9',
'CCDC106',
'CCNA1',
'CCR8',
'CD207',
'CD40LG',
'CD80',
'CDH16',
'CDKAL1',
'CELSR2',
'CHRNG',
'CHST2',
'CKM',
'CLDN16',
'CLDN8',
'CLPS',
'CLSTN3',
'CNTFR',
'COL2A1',
'COPZ2',
'COQ8A',
'CPA2',
'CPB1',
'CPEB3',
'CYP11B2',
'CYP39A1',
'DCC',
'DLK2',
'DTNB',
'EDAR',
'EDN1',
'EDN2',
'EFHD1',
'EGF',
'ENTPD7',
'EPHA5',
'FGF16',
'FGF22',
'FGFR3',
'FGGY',
'FSHB',
'GAMT',
'GDNF',
'GP1BA',
'GP2',
'GPR19',
'GPR3',
'GPRC5C',
'GRID2',
'GTF3C5',
'HNF1A',
'HSD11B2',
'HTR1B',
'HTR1D',
'IDUA',
'IFI44L',
'IFNG',
'IGFBP2',
'IL12B',
'IL5',
'INSL5',
'IRS4',
'ITGB1BP2',
'ITIH3',
'KCND1',
'KCNE2',
'KCNMB1',
'KCNN1',
'KCNQ2',
'KLHDC8A',
'KLK7',
'KLK8',
'KMT2D',
'KRT1',
'KRT13',
'KRT15',
'KRT4',
'KRT5',
'LFNG',
'LGALS7',
'LYPD3',
'MACROH2A2',
'MAGIX',
'MAST3',
'MEFV',
'MFSD6',
'MSH5',
'MTHFR',
'MX1',
'MYH7',
'MYO15A',
'MYOT',
'NGB',
'NOS1',
'NPHS1',
'NPY4R',
'NR4A2',
'NR6A1',
'NRIP2',
'NTF3',
'NUDT11',
'OXT',
'P2RX6',
'P2RY4',
'PAX3',
'PAX4',
'PCDHB1',
'PDCD1',
'PDE6B',
'PDK2',
'PKP1',
'PLAG1',
'PNMT',
'PRKN',
'PRODH',
'PROP1',
'PTGFR',
'PTPRJ',
'RGS11',
'RIBC2',
'RSAD2',
'RYR1',
'RYR2',
'SCGB1A1',
'SCN10A',
'SELENOP',
'SERPINA10',
'SERPINB2',
'SGK1',
'SHOX2',
'SIDT1',
'SKIL',
'SLC12A3',
'SLC16A7',
'SLC25A23',
'SLC29A3',
'SLC30A3',
'SLC38A3',
'SLC5A5',
'SLC6A14',
'SLC6A3',
'SMPX',
'SNCB',
'SNN',
'SOX10',
'SPHK2',
'SPRR3',
'SPTBN2',
'SSTR4',
'STAG3',
'SYNPO',
'TAS2R4',
'TCF7L1',
'TCL1A',
'TENM2',
'TENT5C',
'TEX15',
'TFAP2B',
'TFCP2L1',
'TFF2',
'TG',
'TGFB2',
'TGM1',
'THNSL2',
'THRB',
'TLX1',
'TNNI3',
'TSHB',
'UGT2B17',
'UPK3B',
'VPREB1',
'VPS50',
'WNT16',
'YBX2',
'YPEL1',
'ZBTB16',
'ZC2HC1C',
'ZNF112'},
'HALLMARK_KRAS_SIGNALING_UP': {'ABCB1',
'ACE',
'ADAM17',
'ADAM8',
'ADAMDEC1',
'ADGRA2',
'ADGRL4',
'AKAP12',
'AKT2',
'ALDH1A2',
'ALDH1A3',
'AMMECR1',
'ANGPTL4',
'ANKH',
'ANO1',
'ANXA10',
'APOD',
'ARG1',
'ATG10',
'AVL9',
'BIRC3',
'BMP2',
'BPGM',
'BTBD3',
'BTC',
'C3AR1',
'CA2',
'CAB39L',
'CBL',
'CBR4',
'CBX8',
'CCL20',
'CCND2',
'CCSER2',
'CD37',
'CDADC1',
'CFB',
'CFH',
'CFHR2',
'CIDEA',
'CLEC4A',
'CMKLR1',
'CPE',
'CROT',
'CSF2',
'CSF2RA',
'CTSS',
'CXCL10',
'CXCR4',
'DCBLD2',
'DNMBP',
'DOCK2',
'DUSP6',
'EMP1',
'ENG',
'EPB41L3',
'EPHB2',
'EREG',
'ERO1A',
'ETS1',
'ETV1',
'ETV4',
'ETV5',
'EVI5',
'F13A1',
'F2RL1',
'FBXO4',
'FCER1G',
'FGF9',
'FLT4',
'FUCA1',
'G0S2',
'GABRA3',
'GADD45G',
'GALNT3',
'GFPT2',
'GLRX',
'GNG11',
'GPNMB',
'GPRC5B',
'GUCY1A1',
'GYPC',
'H2BC3',
'HBEGF',
'HDAC9',
'HKDC1',
'HOXD11',
'HSD11B1',
'ID2',
'IGF2',
'IGFBP3',
'IKZF1',
'IL10RA',
'IL1B',
'IL1RL2',
'IL2RG',
'IL33',
'IL7R',
'INHBA',
'IRF8',
'ITGA2',
'ITGB2',
'ITGBL1',
'JUP',
'KCNN4',
'KIF5C',
'KLF4',
'LAPTM5',
'LAT2',
'LCP1',
'LIF',
'LY96',
'MAFB',
'MALL',
'MAP3K1',
'MAP4K1',
'MAP7',
'MMD',
'MMP10',
'MMP11',
'MMP9',
'MPZL2',
'MTMR10',
'MYCN',
'NAP1L2',
'NGF',
'NIN',
'NR0B2',
'NR1H4',
'NRP1',
'PCP4',
'PCSK1N',
'PDCD1LG2',
'PECAM1',
'PEG3',
'PIGR',
'PLAT',
'PLAU',
'PLAUR',
'PLEK2',
'PLVAP',
'PPBP',
'PPP1R15A',
'PRDM1',
'PRELID3B',
'PRKG2',
'PRRX1',
'PSMB8',
'PTBP2',
'PTCD2',
'PTGS2',
'PTPRR',
'RABGAP1L',
'RBM4',
'RBP4',
'RELN',
'RETN',
'RGS16',
'SATB1',
'SCG3',
'SCG5',
'SCN1B',
'SDCCAG8',
'SEMA3B',
'SERPINA3',
'SLPI',
'SNAP25',
'SNAP91',
'SOX9',
'SPARCL1',
'SPON1',
'SPP1',
'SPRY2',
'ST6GAL1',
'STRN',
'TFPI',
'TLR8',
'TMEM100',
'TMEM158',
'TMEM176A',
'TMEM176B',
'TNFAIP3',
'TNFRSF1B',
'TNNT2',
'TOR1AIP2',
'TPH1',
'TRAF1',
'TRIB1',
'TRIB2',
'TSPAN1',
'TSPAN13',
'TSPAN7',
'USH1C',
'USP12',
'VWA5A',
'WDR33',
'WNT7A',
'YRDC',
'ZNF277',
'ZNF639'},
'HALLMARK_MITOTIC_SPINDLE': {'ABI1',
'ABL1',
'ABR',
'ACTN4',
'AKAP13',
'ALMS1',
'ALS2',
'ANLN',
'APC',
'ARAP3',
'ARF6',
'ARFGEF1',
'ARFIP2',
'ARHGAP10',
'ARHGAP27',
'ARHGAP29',
'ARHGAP4',
'ARHGAP5',
'ARHGDIA',
'ARHGEF11',
'ARHGEF12',
'ARHGEF2',
'ARHGEF3',
'ARHGEF7',
'ARL8A',
'ATG4B',
'AURKA',
'BCAR1',
'BCL2L11',
'BCR',
'BIN1',
'BIRC5',
'BRCA2',
'BUB1',
'CAPZB',
'CCDC88A',
'CCNB2',
'CD2AP',
'CDC27',
'CDC42',
'CDC42BPA',
'CDC42EP1',
'CDC42EP2',
'CDC42EP4',
'CDK1',
'CDK5RAP2',
'CENPE',
'CENPF',
'CENPJ',
'CEP131',
'CEP192',
'CEP250',
'CEP57',
'CEP72',
'CKAP5',
'CLASP1',
'CLIP1',
'CLIP2',
'CNTRL',
'CNTROB',
'CSNK1D',
'CTTN',
'CYTH2',
'DLG1',
'DLGAP5',
'DOCK2',
'DOCK4',
'DST',
'DYNC1H1',
'DYNLL2',
'ECT2',
'EPB41',
'EPB41L2',
'ESPL1',
'EZR',
'FARP1',
'FBXO5',
'FGD4',
'FGD6',
'FLNA',
'FLNB',
'FSCN1',
'GEMIN4',
'GSN',
'HDAC6',
'HOOK3',
'INCENP',
'ITSN1',
'KATNA1',
'KATNB1',
'KIF11',
'KIF15',
'KIF1B',
'KIF20B',
'KIF22',
'KIF23',
'KIF2C',
'KIF3B',
'KIF3C',
'KIF4A',
'KIF5B',
'KIFAP3',
'KLC1',
'KNTC1',
'KPTN',
'LATS1',
'LLGL1',
'LMNB1',
'LRPPRC',
'MAP1S',
'MAP3K11',
'MAPRE1',
'MARCKS',
'MARK4',
'MID1',
'MID1IP1',
'MYH10',
'MYH9',
'MYO1E',
'MYO9B',
'NCK1',
'NCK2',
'NDC80',
'NEDD9',
'NEK2',
'NET1',
'NF1',
'NIN',
'NOTCH2',
'NUMA1',
'NUSAP1',
'OPHN1',
'PAFAH1B1',
'PALLD',
'PCGF5',
'PCM1',
'PCNT',
'PDLIM5',
'PIF1',
'PKD2',
'PLEKHG2',
'PLK1',
'PPP4R2',
'PRC1',
'PREX1',
'PXN',
'RAB3GAP1',
'RABGAP1',
'RACGAP1',
'RALBP1',
'RANBP9',
'RAPGEF5',
'RAPGEF6',
'RASA1',
'RASA2',
'RASAL2',
'RFC1',
'RHOF',
'RHOT2',
'RICTOR',
'ROCK1',
'SAC3D1',
'SASS6',
'SEPTIN9',
'SHROOM1',
'SHROOM2',
'SMC1A',
'SMC3',
'SMC4',
'SORBS2',
'SOS1',
'SPTAN1',
'SPTBN1',
'SSH2',
'STAU1',
'STK38L',
'SUN2',
'SYNPO',
'TAOK2',
'TBCD',
'TIAM1',
'TLK1',
'TOP2A',
'TPX2',
'TRIO',
'TSC1',
'TTK',
'TUBA4A',
'TUBD1',
'TUBGCP2',
'TUBGCP3',
'TUBGCP5',
'TUBGCP6',
'UXT',
'VCL',
'WASF1',
'WASF2',
'WASL',
'YWHAE'},
'HALLMARK_MTORC1_SIGNALING': {'ABCF2',
'ACACA',
'ACLY',
'ACSL3',
'ACTR2',
'ACTR3',
'ADD3',
'ADIPOR2',
'AK4',
'ALDOA',
'ARPC5L',
'ASNS',
'ATP2A2',
'ATP5MC1',
'ATP6V1D',
'AURKA',
'BCAT1',
'BHLHE40',
'BTG2',
'BUB1',
'CACYBP',
'CALR',
'CANX',
'CCNF',
'CCNG1',
'CCT6A',
'CD9',
'CDC25A',
'CDKN1A',
'CFP',
'COPS5',
'CORO1A',
'CTH',
'CTSC',
'CXCR4',
'CYB5B',
'CYP51A1',
'DAPP1',
'DDIT3',
'DDIT4',
'DDX39A',
'DHCR24',
'DHCR7',
'DHFR',
'EBP',
'EDEM1',
'EEF1E1',
'EGLN3',
'EIF2S2',
'ELOVL5',
'ELOVL6',
'ENO1',
'EPRS1',
'ERO1A',
'ETF1',
'FADS1',
'FADS2',
'FDXR',
'FGL2',
'FKBP2',
'G6PD',
'GAPDH',
'GBE1',
'GCLC',
'GGA2',
'GLA',
'GLRX',
'GMPS',
'GOT1',
'GPI',
'GSK3B',
'GSR',
'GTF2H1',
'HK2',
'HMBS',
'HMGCR',
'HMGCS1',
'HPRT1',
'HSP90B1',
'HSPA4',
'HSPA5',
'HSPA9',
'HSPD1',
'HSPE1',
'IDH1',
'IDI1',
'IFI30',
'IFRD1',
'IGFBP5',
'IMMT',
'INSIG1',
'ITGB2',
'LDHA',
'LDLR',
'LGMN',
'LTA4H',
'M6PR',
'MAP2K3',
'MCM2',
'MCM4',
'ME1',
'MLLT11',
'MTHFD2',
'MTHFD2L',
'NAMPT',
'NFIL3',
'NFKBIB',
'NFYC',
'NHERF1',
'NIBAN1',
'NMT1',
'NUFIP1',
'NUP205',
'NUPR1',
'P4HA1',
'PDAP1',
'PDK1',
'PFKL',
'PGK1',
'PGM1',
'PHGDH',
'PIK3R3',
'PITPNB',
'PLK1',
'PLOD2',
'PNO1',
'PNP',
'POLR3G',
'PPA1',
'PPIA',
'PPP1R15A',
'PRDX1',
'PSAT1',
'PSMA3',
'PSMA4',
'PSMB5',
'PSMC2',
'PSMC4',
'PSMC6',
'PSMD12',
'PSMD13',
'PSMD14',
'PSME3',
'PSMG1',
'PSPH',
'QDPR',
'RAB1A',
'RDH11',
'RIT1',
'RPA1',
'RPN1',
'RRM2',
'RRP9',
'SC5D',
'SCD',
'SDF2L1',
'SEC11A',
'SERP1',
'SERPINH1',
'SHMT2',
'SKAP2',
'SLA',
'SLC1A4',
'SLC1A5',
'SLC2A1',
'SLC2A3',
'SLC37A4',
'SLC6A6',
'SLC7A11',
'SLC7A5',
'SORD',
'SQLE',
'SQSTM1',
'SRD5A1',
'SSR1',
'STARD4',
'STC1',
'STIP1',
'SYTL2',
'TBK1',
'TCEA1',
'TES',
'TFRC',
'TM7SF2',
'TMEM97',
'TOMM40',
'TPI1',
'TRIB3',
'TUBA4A',
'TUBG1',
'TXNRD1',
'UBE2D3',
'UCHL5',
'UFM1',
'UNG',
'USO1',
'VLDLR',
'WARS1',
'XBP1',
'YKT6'},
'HALLMARK_MYC_TARGETS_V1': {'ABCE1',
'ACP1',
'AIMP2',
'AP3S1',
'APEX1',
'BUB3',
'C1QBP',
'CAD',
'CANX',
'CBX3',
'CCNA2',
'CCT2',
'CCT3',
'CCT4',
'CCT5',
'CCT7',
'CDC20',
'CDC45',
'CDK2',
'CDK4',
'CLNS1A',
'CNBP',
'COPS5',
'COX5A',
'CSTF2',
'CTPS1',
'CUL1',
'CYC1',
'DDX18',
'DDX21',
'DEK',
'DHX15',
'DUT',
'EEF1B2',
'EIF1AX',
'EIF2S1',
'EIF2S2',
'EIF3B',
'EIF3D',
'EIF3J',
'EIF4A1',
'EIF4E',
'EIF4G2',
'EIF4H',
'EPRS1',
'ERH',
'ETF1',
'EXOSC7',
'FAM120A',
'FBL',
'G3BP1',
'GLO1',
'GNL3',
'GOT2',
'GSPT1',
'H2AZ1',
'HDAC2',
'HDDC2',
'HDGF',
'HNRNPA1',
'HNRNPA2B1',
'HNRNPA3',
'HNRNPC',
'HNRNPD',
'HNRNPR',
'HNRNPU',
'HPRT1',
'HSP90AB1',
'HSPD1',
'HSPE1',
'IARS1',
'IFRD1',
'ILF2',
'IMPDH2',
'KARS1',
'KPNA2',
'KPNB1',
'LDHA',
'LSM2',
'LSM7',
'MAD2L1',
'MCM2',
'MCM4',
'MCM5',
'MCM6',
'MCM7',
'MRPL23',
'MRPL9',
'MRPS18B',
'MYC',
'NAP1L1',
'NCBP1',
'NCBP2',
'NDUFAB1',
'NHP2',
'NME1',
'NOLC1',
'NOP16',
'NOP56',
'NPM1',
'ODC1',
'ORC2',
'PA2G4',
'PABPC1',
'PABPC4',
'PCBP1',
'PCNA',
'PGK1',
'PHB1',
'PHB2',
'POLD2',
'POLE3',
'PPIA',
'PPM1G',
'PRDX3',
'PRDX4',
'PRPF31',
'PRPS2',
'PSMA1',
'PSMA2',
'PSMA4',
'PSMA6',
'PSMA7',
'PSMB2',
'PSMB3',
'PSMC4',
'PSMC6',
'PSMD1',
'PSMD14',
'PSMD3',
'PSMD7',
'PSMD8',
'PTGES3',
'PWP1',
'RACK1',
'RAD23B',
'RAN',
'RANBP1',
'RFC4',
'RNPS1',
'RPL14',
'RPL18',
'RPL22',
'RPL34',
'RPL6',
'RPLP0',
'RPS10',
'RPS2',
'RPS3',
'RPS5',
'RPS6',
'RRM1',
'RRP9',
'RSL1D1',
'RUVBL2',
'SERBP1',
'SET',
'SF3A1',
'SF3B3',
'SLC25A3',
'SMARCC1',
'SNRPA',
'SNRPA1',
'SNRPB2',
'SNRPD1',
'SNRPD2',
'SNRPD3',
'SNRPG',
'SRM',
'SRPK1',
'SRSF1',
'SRSF2',
'SRSF3',
'SRSF7',
'SSB',
'SSBP1',
'STARD7',
'SYNCRIP',
'TARDBP',
'TCP1',
'TFDP1',
'TOMM70',
'TRA2B',
'TRIM28',
'TUFM',
'TXNL4A',
'TYMS',
'U2AF1',
'UBA2',
'UBE2E1',
'UBE2L3',
'USP1',
'VBP1',
'VDAC1',
'VDAC3',
'XPO1',
'XPOT',
'XRCC6',
'YWHAE',
'YWHAQ'},
'HALLMARK_MYC_TARGETS_V2': {'AIMP2',
'BYSL',
'CBX3',
'CDK4',
'DCTPP1',
'DDX18',
'DUSP2',
'EXOSC5',
'FARSA',
'GNL3',
'GRWD1',
'HK2',
'HSPD1',
'HSPE1',
'IMP4',
'IPO4',
'LAS1L',
'MAP3K6',
'MCM4',
'MCM5',
'MPHOSPH10',
'MRTO4',
'MYBBP1A',
'MYC',
'NDUFAF4',
'NIP7',
'NOC4L',
'NOLC1',
'NOP16',
'NOP2',
'NOP56',
'NPM1',
'PA2G4',
'PES1',
'PHB1',
'PLK1',
'PLK4',
'PPAN',
'PPRC1',
'PRMT3',
'PUS1',
'RABEPK',
'RCL1',
'RRP12',
'RRP9',
'SLC19A1',
'SLC29A2',
'SORD',
'SRM',
'SUPV3L1',
'TBRG4',
'TCOF1',
'TFB2M',
'TMEM97',
'UNG',
'UTP20',
'WDR43',
'WDR74'},
'HALLMARK_MYOGENESIS': {'ABLIM1',
'ACHE',
'ACSL1',
'ACTA1',
'ACTC1',
'ACTN2',
'ACTN3',
'ADAM12',
'ADCY9',
'AEBP1',
'AGL',
'AGRN',
'AK1',
'AKT2',
'ANKRD2',
'APLNR',
'APOD',
'APP',
'ATP2A1',
'ATP6AP1',
'BAG1',
'BDKRB2',
'BHLHE40',
'BIN1',
'CACNA1H',
'CACNG1',
'CAMK2B',
'CASQ1',
'CASQ2',
'CAV3',
'CD36',
'CDH13',
'CDKN1A',
'CFD',
'CHRNA1',
'CHRNB1',
'CHRNG',
'CKB',
'CKM',
'CKMT2',
'CLU',
'CNN3',
'COL15A1',
'COL1A1',
'COL3A1',
'COL4A2',
'COL6A2',
'COL6A3',
'COX6A2',
'COX7A1',
'CRAT',
'CRYAB',
'CSRP3',
'CTF1',
'DAPK2',
'DENND2B',
'DES',
'DMD',
'DMPK',
'DTNA',
'EFS',
'EIF4A2',
'ENO3',
'EPHB3',
'ERBB3',
'FABP3',
'FDPS',
'FGF2',
'FHL1',
'FKBP1B',
'FLII',
'FOXO4',
'FST',
'FXYD1',
'GAA',
'GABARAPL2',
'GADD45B',
'GJA5',
'GNAO1',
'GPX3',
'GSN',
'HBEGF',
'HDAC5',
'HRC',
'HSPB2',
'HSPB8',
'IFRD1',
'IGF1',
'IGFBP3',
'IGFBP7',
'ITGA7',
'ITGB1',
'ITGB4',
'ITGB5',
'KCNH1',
'KCNH2',
'KIFC3',
'KLF5',
'LAMA2',
'LARGE1',
'LDB3',
'LPIN1',
'LSP1',
'MAPK12',
'MAPRE3',
'MB',
'MEF2A',
'MEF2C',
'MEF2D',
'MRAS',
'MYBPC3',
'MYBPH',
'MYF6',
'MYH1',
'MYH11',
'MYH2',
'MYH3',
'MYH4',
'MYH7',
'MYH8',
'MYH9',
'MYL1',
'MYL11',
'MYL2',
'MYL3',
'MYL4',
'MYL6B',
'MYL7',
'MYLK',
'MYO1C',
'MYOG',
'MYOM1',
'MYOM2',
'MYOZ1',
'NAV2',
'NCAM1',
'NOS1',
'NOTCH1',
'NQO1',
'OCEL1',
'PC',
'PDE4DIP',
'PDLIM7',
'PFKM',
'PGAM2',
'PICK1',
'PKIA',
'PLXNB2',
'PPFIA4',
'PPP1R3C',
'PRNP',
'PSEN2',
'PTGIS',
'PTP4A3',
'PVALB',
'PYGM',
'RB1',
'REEP1',
'RIT1',
'RYR1',
'SCD',
'SCHIP1',
'SGCA',
'SGCD',
'SGCG',
'SH2B1',
'SH3BGR',
'SIRT2',
'SLC6A8',
'SLN',
'SMTN',
'SOD3',
'SORBS1',
'SORBS3',
'SPARC',
'SPDEF',
'SPEG',
'SPHK1',
'SPTAN1',
'SSPN',
'STC2',
'SVIL',
'SYNGR2',
'TAGLN',
'TCAP',
'TEAD4',
'TGFB1',
'TNNC1',
'TNNC2',
'TNNI1',
'TNNI2',
'TNNT1',
'TNNT2',
'TNNT3',
'TPD52L1',
'TPM2',
'TPM3',
'TSC2',
'VIPR1',
'WWTR1'},
'HALLMARK_NOTCH_SIGNALING': {'APH1A',
'ARRB1',
'CCND1',
'CUL1',
'DLL1',
'DTX1',
'DTX2',
'DTX4',
'FBXW11',
'FZD1',
'FZD5',
'FZD7',
'HES1',
'HEYL',
'JAG1',
'KAT2A',
'LFNG',
'MAML2',
'NOTCH1',
'NOTCH2',
'NOTCH3',
'PPARD',
'PRKCA',
'PSEN2',
'PSENEN',
'RBX1',
'SAP30',
'SKP1',
'ST3GAL6',
'TCF7L2',
'WNT2',
'WNT5A'},
'HALLMARK_OXIDATIVE_PHOSPHORYLATION': {'ABCB7',
'ACAA1',
'ACAA2',
'ACADM',
'ACADSB',
'ACADVL',
'ACAT1',
'ACO2',
'AFG3L2',
'AIFM1',
'ALAS1',
'ALDH6A1',
'ATP1B1',
'ATP5F1A',
'ATP5F1B',
'ATP5F1C',
'ATP5F1D',
'ATP5F1E',
'ATP5MC1',
'ATP5MC2',
'ATP5MC3',
'ATP5ME',
'ATP5MF',
'ATP5MG',
'ATP5PB',
'ATP5PD',
'ATP5PF',
'ATP5PO',
'ATP6AP1',
'ATP6V0B',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1C1',
'ATP6V1D',
'ATP6V1E1',
'ATP6V1F',
'ATP6V1G1',
'ATP6V1H',
'BAX',
'BCKDHA',
'BDH2',
'CASP7',
'COX10',
'COX11',
'COX15',
'COX17',
'COX4I1',
'COX5A',
'COX5B',
'COX6A1',
'COX6B1',
'COX6C',
'COX7A2',
'COX7A2L',
'COX7B',
'COX7C',
'COX8A',
'CPT1A',
'CS',
'CYB5A',
'CYB5R3',
'CYC1',
'CYCS',
'DECR1',
'DLAT',
'DLD',
'DLST',
'ECH1',
'ECHS1',
'ECI1',
'ETFA',
'ETFB',
'ETFDH',
'FDX1',
'FH',
'FXN',
'GLUD1',
'GOT2',
'GPI',
'GPX4',
'GRPEL1',
'HADHA',
'HADHB',
'HCCS',
'HSD17B10',
'HSPA9',
'HTRA2',
'IDH1',
'IDH2',
'IDH3A',
'IDH3B',
'IDH3G',
'IMMT',
'ISCA1',
'ISCU',
'LDHA',
'LDHB',
'LRPPRC',
'MAOB',
'MDH1',
'MDH2',
'MFN2',
'MGST3',
'MPC1',
'MRPL11',
'MRPL15',
'MRPL34',
'MRPL35',
'MRPS11',
'MRPS12',
'MRPS15',
'MRPS22',
'MRPS30',
'MTRF1',
'MTRR',
'MTX2',
'NDUFA1',
'NDUFA2',
'NDUFA3',
'NDUFA4',
'NDUFA5',
'NDUFA6',
'NDUFA7',
'NDUFA8',
'NDUFA9',
'NDUFAB1',
'NDUFB1',
'NDUFB2',
'NDUFB3',
'NDUFB4',
'NDUFB5',
'NDUFB6',
'NDUFB7',
'NDUFB8',
'NDUFC1',
'NDUFC2',
'NDUFS1',
'NDUFS2',
'NDUFS3',
'NDUFS4',
'NDUFS6',
'NDUFS7',
'NDUFS8',
'NDUFV1',
'NDUFV2',
'NNT',
'NQO2',
'OAT',
'OGDH',
'OPA1',
'OXA1L',
'PDHA1',
'PDHB',
'PDHX',
'PDK4',
'PDP1',
'PHB2',
'PHYH',
'PMPCA',
'POLR2F',
'POR',
'PRDX3',
'RETSAT',
'RHOT1',
'RHOT2',
'SDHA',
'SDHB',
'SDHC',
'SDHD',
'SLC25A11',
'SLC25A12',
'SLC25A20',
'SLC25A3',
'SLC25A4',
'SLC25A5',
'SLC25A6',
'SUCLA2',
'SUCLG1',
'SUPV3L1',
'SURF1',
'TCIRG1',
'TIMM10',
'TIMM13',
'TIMM17A',
'TIMM50',
'TIMM8B',
'TIMM9',
'TOMM22',
'TOMM70',
'UQCR10',
'UQCR11',
'UQCRB',
'UQCRC1',
'UQCRC2',
'UQCRFS1',
'UQCRH',
'UQCRQ',
'VDAC1',
'VDAC2',
'VDAC3'},
'HALLMARK_P53_PATHWAY': {'ABAT',
'ABCC5',
'ABHD4',
'ACVR1B',
'ADA',
'AEN',
'AK1',
'ALOX15B',
'ANKRA2',
'APAF1',
'APP',
'ATF3',
'BAIAP2',
'BAK1',
'BAX',
'BLCAP',
'BMP2',
'BTG1',
'BTG2',
'CASP1',
'CCND2',
'CCND3',
'CCNG1',
'CCNK',
'CCP110',
'CD81',
'CD82',
'CDH13',
'CDK5R1',
'CDKN1A',
'CDKN2A',
'CDKN2AIP',
'CDKN2B',
'CEBPA',
'CGRRF1',
'CLCA2',
'COQ8A',
'CSRNP2',
'CTSD',
'CTSF',
'CYFIP2',
'DCXR',
'DDB2',
'DDIT3',
'DDIT4',
'DEF6',
'DGKA',
'DNTTIP2',
'DRAM1',
'EI24',
'ELP1',
'EPHA2',
'EPHX1',
'EPS8L2',
'ERCC5',
'F2R',
'FAM162A',
'FAS',
'FBXW7',
'FDXR',
'FGF13',
'FOS',
'FOXO3',
'FUCA1',
'GADD45A',
'GLS2',
'GM2A',
'GPX2',
'H1-2',
'H2AC25',
'H2AJ',
'HBEGF',
'HDAC3',
'HEXIM1',
'HINT1',
'HMOX1',
'HRAS',
'HSPA4L',
'IER3',
'IER5',
'IFI30',
'IL1A',
'INHBB',
'IP6K2',
'IRAG2',
'IRAK1',
'ISCU',
'ITGB4',
'JAG2',
'JUN',
'KIF13B',
'KLF4',
'KLK8',
'KRT17',
'LDHB',
'LIF',
'MAPKAPK3',
'MDM2',
'MKNK2',
'MXD1',
'MXD4',
'NDRG1',
'NHLH2',
'NINJ1',
'NOL8',
'NOTCH1',
'NUDT15',
'NUPR1',
'OSGIN1',
'PCNA',
'PDGFA',
'PERP',
'PHLDA3',
'PIDD1',
'PITPNC1',
'PLK2',
'PLK3',
'PLXNB2',
'PMM1',
'POLH',
'POM121',
'PPM1D',
'PPP1R15A',
'PRKAB1',
'PRMT2',
'PROCR',
'PTPN14',
'PTPRE',
'PVT1',
'RAB40C',
'RACK1',
'RAD51C',
'RAD9A',
'RALGDS',
'RAP2B',
'RB1',
'RCHY1',
'RETSAT',
'RGS16',
'RHBDF2',
'RNF19B',
'RPL18',
'RPL36',
'RPS12',
'RPS27L',
'RRAD',
'RRP8',
'RXRA',
'S100A10',
'S100A4',
'SAT1',
'SDC1',
'SEC61A1',
'SERPINB5',
'SERTAD3',
'SESN1',
'SFN',
'SLC19A2',
'SLC35D1',
'SLC3A2',
'SLC7A11',
'SOCS1',
'SP1',
'SPHK1',
'ST14',
'STEAP3',
'STOM',
'TAP1',
'TAX1BP3',
'TCHH',
'TCN2',
'TGFA',
'TGFB1',
'TM4SF1',
'TM7SF3',
'TNFSF9',
'TNNI1',
'TOB1',
'TP53',
'TP63',
'TPD52L1',
'TPRKB',
'TRAF4',
'TRAFD1',
'TRIAP1',
'TRIB3',
'TSC22D1',
'TSPYL2',
'TXNIP',
'UPP1',
'VAMP8',
'VDR',
'VWA5A',
'WRAP73',
'WWP1',
'XPC',
'ZBTB16',
'ZFP36L1',
'ZMAT3',
'ZNF365'},
'HALLMARK_PANCREAS_BETA_CELLS': {'ABCC8',
'AKT3',
'CHGA',
'DCX',
'DPP4',
'ELP4',
'FOXA2',
'FOXO1',
'G6PC2',
'GCG',
'GCK',
'HNF1A',
'IAPP',
'INS',
'INSM1',
'ISL1',
'LMO2',
'MAFB',
'NEUROD1',
'NEUROG3',
'NKX2-2',
'NKX6-1',
'PAK3',
'PAX4',
'PAX6',
'PCSK1',
'PCSK2',
'PDX1',
'PKLR',
'SCGN',
'SEC11A',
'SLC2A2',
'SPCS1',
'SRP14',
'SRP9',
'SRPRB',
'SST',
'STXBP1',
'SYT13',
'VDR'},
'HALLMARK_PEROXISOME': {'ABCB1',
'ABCB4',
'ABCB9',
'ABCC5',
'ABCC8',
'ABCD1',
'ABCD2',
'ABCD3',
'ACAA1',
'ACOT8',
'ACOX1',
'ACSL1',
'ACSL4',
'ACSL5',
'ALB',
'ALDH1A1',
'ALDH9A1',
'ATXN1',
'BCL10',
'CACNA1B',
'CADM1',
'CAT',
'CDK7',
'CEL',
'CLN6',
'CLN8',
'CNBP',
'CRABP1',
'CRABP2',
'CRAT',
'CTBP1',
'CTPS1',
'DHCR24',
'DHRS3',
'DIO1',
'DLG4',
'ECH1',
'ECI2',
'EHHADH',
'ELOVL5',
'EPHX2',
'ERCC1',
'ERCC3',
'ESR2',
'FABP6',
'FADS1',
'FDPS',
'FIS1',
'GNPAT',
'GSTK1',
'HAO2',
'HMGCL',
'HRAS',
'HSD11B2',
'HSD17B11',
'HSD17B4',
'HSD3B7',
'IDE',
'IDH1',
'IDH2',
'IDI1',
'ISOC1',
'ITGB1BP1',
'LONP2',
'MLYCD',
'MSH2',
'MVP',
'NR1I2',
'NUDT19',
'PABPC1',
'PEX11A',
'PEX11B',
'PEX13',
'PEX14',
'PEX2',
'PEX5',
'PEX6',
'PRDX1',
'PRDX5',
'RDH11',
'RETSAT',
'RXRG',
'SCGB1A1',
'SCP2',
'SEMA3C',
'SERPINA6',
'SIAH1',
'SLC23A2',
'SLC25A17',
'SLC25A19',
'SLC25A4',
'SLC27A2',
'SLC35B2',
'SMARCC1',
'SOD1',
'SOD2',
'STS',
'SULT2B1',
'TOP2A',
'TSPO',
'TTR',
'UGT2B17',
'VPS4B',
'YWHAH'},
'HALLMARK_PI3K_AKT_MTOR_SIGNALING': {'ACACA',
'ACTR2',
'ACTR3',
'ADCY2',
'AKT1',
'AKT1S1',
'AP2M1',
'ARF1',
'ARHGDIA',
'ARPC3',
'ATF1',
'CAB39',
'CAB39L',
'CALR',
'CAMK4',
'CDK1',
'CDK2',
'CDK4',
'CDKN1A',
'CDKN1B',
'CFL1',
'CLTC',
'CSNK2B',
'CXCR4',
'DAPP1',
'DDIT3',
'DUSP3',
'E2F1',
'ECSIT',
'EGFR',
'EIF4E',
'FASLG',
'FGF17',
'FGF22',
'FGF6',
'GNA14',
'GNGT1',
'GRB2',
'GRK2',
'GSK3B',
'HRAS',
'HSP90B1',
'IL2RG',
'IL4',
'IRAK4',
'ITPR2',
'LCK',
'MAP2K3',
'MAP2K6',
'MAP3K7',
'MAPK1',
'MAPK10',
'MAPK8',
'MAPK9',
'MAPKAP1',
'MKNK1',
'MKNK2',
'MYD88',
'NCK1',
'NFKBIB',
'NGF',
'NOD1',
'PAK4',
'PDK1',
'PFN1',
'PIK3R3',
'PIKFYVE',
'PIN1',
'PITX2',
'PLA2G12A',
'PLCB1',
'PLCG1',
'PPP1CA',
'PPP2R1B',
'PRKAA2',
'PRKAG1',
'PRKAR2A',
'PRKCB',
'PTEN',
'PTPN11',
'RAC1',
'RAF1',
'RALB',
'RIPK1',
'RIT1',
'RPS6KA1',
'RPS6KA3',
'RPTOR',
'SFN',
'SLA',
'SLC2A1',
'SMAD2',
'SQSTM1',
'STAT2',
'TBK1',
'THEM4',
'TIAM1',
'TNFRSF1A',
'TRAF2',
'TRIB3',
'TSC2',
'UBE2D3',
'UBE2N',
'VAV3',
'YWHAB'},
'HALLMARK_PROTEIN_SECRETION': {'ABCA1',
'ADAM10',
'ANP32E',
'AP1G1',
'AP2B1',
'AP2M1',
'AP2S1',
'AP3B1',
'AP3S1',
'ARCN1',
'ARF1',
'ARFGAP3',
'ARFGEF1',
'ARFGEF2',
'ARFIP1',
'ATP1A1',
'ATP6V1B1',
'ATP6V1H',
'ATP7A',
'BET1',
'BNIP3',
'CAV2',
'CD63',
'CLCN3',
'CLN5',
'CLTA',
'CLTC',
'COG2',
'COPB1',
'COPB2',
'COPE',
'CTSC',
'DNM1L',
'DOP1A',
'DST',
'EGFR',
'ERGIC3',
'GALC',
'GBF1',
'GLA',
'GNAS',
'GOLGA4',
'GOSR2',
'ICA1',
'IGF2R',
'KIF1B',
'KRT18',
'LAMP2',
'LMAN1',
'M6PR',
'MAPK1',
'MON2',
'NAPA',
'NAPG',
'OCRL',
'PAM',
'PPT1',
'RAB14',
'RAB22A',
'RAB2A',
'RAB5A',
'RAB9A',
'RER1',
'RPS6KA3',
'SCAMP1',
'SCAMP3',
'SCRN1',
'SEC22B',
'SEC24D',
'SEC31A',
'SGMS1',
'SH3GL2',
'SNAP23',
'SNX2',
'SOD1',
'SSPN',
'STAM',
'STX12',
'STX16',
'STX7',
'TMED10',
'TMED2',
'TMX1',
'TOM1L1',
'TPD52',
'TSG101',
'TSPAN8',
'USO1',
'VAMP3',
'VAMP4',
'VAMP7',
'VPS45',
'VPS4B',
'YIPF6',
'YKT6',
'ZW10'},
'HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY': {'ABCC1',
'ATOX1',
'CAT',
'CDKN2D',
'EGLN2',
'ERCC2',
'FES',
'FTL',
'G6PD',
'GCLC',
'GCLM',
'GLRX',
'GLRX2',
'GPX3',
'GPX4',
'GSR',
'HHEX',
'HMOX2',
'IPCEF1',
'JUNB',
'LAMTOR5',
'LSP1',
'MBP',
'MGST1',
'MPO',
'MSRA',
'NDUFA6',
'NDUFB4',
'NDUFS2',
'NQO1',
'OXSR1',
'PDLIM1',
'PFKP',
'PRDX1',
'PRDX2',
'PRDX4',
'PRDX6',
'PRNP',
'PTPA',
'SBNO2',
'SCAF4',
'SELENOS',
'SOD1',
'SOD2',
'SRXN1',
'STK25',
'TXN',
'TXNRD1',
'TXNRD2'},
'HALLMARK_SPERMATOGENESIS': {'ACE',
'ACRBP',
'ACRV1',
'ACTL7B',
'ADAD1',
'ADAM2',
'ADCYAP1',
'AGFG1',
'AKAP4',
'ALOX15',
'ARL4A',
'ART3',
'AURKA',
'BRAF',
'BUB1',
'CAMK4',
'CCNA1',
'CCNB2',
'CCT6B',
'CDK1',
'CDKN3',
'CFTR',
'CHFR',
'CHRM4',
'CLGN',
'CLPB',
'CLVS1',
'CNIH2',
'COIL',
'CRISP2',
'CSNK2A2',
'CST8',
'DBF4',
'DCC',
'DDX25',
'DDX4',
'DMC1',
'DMRT1',
'DNAJB8',
'DPEP3',
'ELOVL3',
'EZH2',
'GAD1',
'GAPDHS',
'GFI1',
'GMCL1',
'GPR182',
'GRM8',
'GSG1',
'GSTM3',
'H1-6',
'HBZ',
'HOXB1',
'HSPA1L',
'HSPA2',
'HSPA4L',
'HTR5A',
'IDE',
'IFT88',
'IL12RB2',
'IL13RA2',
'IP6K1',
'JAM3',
'KIF2C',
'LDHC',
'LPIN1',
'MAP7',
'MAST2',
'MEP1B',
'MLF1',
'MLLT10',
'MTNR1A',
'MTOR',
'NAA11',
'NCAPH',
'NEFH',
'NEK2',
'NF2',
'NOS1',
'NPHP1',
'NPY5R',
'OAZ3',
'ODF1',
'PACRG',
'PAPOLB',
'PARP2',
'PCSK1N',
'PCSK4',
'PDHA2',
'PEBP1',
'PGK2',
'PGS1',
'PHF7',
'PHKG2',
'PIAS2',
'POMC',
'PRKAR2A',
'PRM2',
'PSMG1',
'RAD17',
'RFC4',
'RPL39L',
'SCG3',
'SCG5',
'SEPTIN4',
'SHE',
'SIRT1',
'SLC12A2',
'SLC2A5',
'SNAP91',
'SPATA6',
'STAM2',
'STRBP',
'SYCP1',
'TALDO1',
'TCP11',
'TEKT2',
'THEG',
'TKTL1',
'TLE4',
'TNNI3',
'TNP1',
'TNP2',
'TOPBP1',
'TSN',
'TSSK2',
'TTK',
'TUBA3C',
'TULP2',
'VDAC3',
'YBX2',
'ZC2HC1C',
'ZC3H14',
'ZNRF4',
'ZPBP'},
'HALLMARK_TGF_BETA_SIGNALING': {'ACVR1',
'APC',
'ARID4B',
'BCAR3',
'BMP2',
'BMPR1A',
'BMPR2',
'CDH1',
'CDK9',
'CDKN1C',
'CTNNB1',
'ENG',
'FKBP1A',
'FNTA',
'FURIN',
'HDAC1',
'HIPK2',
'ID1',
'ID2',
'ID3',
'IFNGR2',
'JUNB',
'KLF10',
'LEFTY2',
'LTBP2',
'MAP3K7',
'NCOR2',
'NOG',
'PMEPA1',
'PPM1A',
'PPP1CA',
'PPP1R15A',
'RAB31',
'RHOA',
'SERPINE1',
'SKI',
'SKIL',
'SLC20A1',
'SMAD1',
'SMAD3',
'SMAD6',
'SMAD7',
'SMURF1',
'SMURF2',
'SPTBN1',
'TGFB1',
'TGFBR1',
'TGIF1',
'THBS1',
'TJP1',
'TRIM33',
'UBE2D3',
'WWTR1',
'XIAP'},
'HALLMARK_TNFA_SIGNALING_VIA_NFKB': {'ABCA1',
'ACKR3',
'AREG',
'ATF3',
'ATP2B1',
'B4GALT1',
'B4GALT5',
'BCL2A1',
'BCL3',
'BCL6',
'BHLHE40',
'BIRC2',
'BIRC3',
'BMP2',
'BTG1',
'BTG2',
'BTG3',
'CCL2',
'CCL20',
'CCL4',
'CCL5',
'CCN1',
'CCND1',
'CCNL1',
'CCRL2',
'CD44',
'CD69',
'CD80',
'CD83',
'CDKN1A',
'CEBPB',
'CEBPD',
'CFLAR',
'CLCF1',
'CSF1',
'CSF2',
'CXCL1',
'CXCL10',
'CXCL11',
'CXCL2',
'CXCL3',
'CXCL6',
'DENND5A',
'DNAJB4',
'DRAM1',
'DUSP1',
'DUSP2',
'DUSP4',
'DUSP5',
'EDN1',
'EFNA1',
'EGR1',
'EGR2',
'EGR3',
'EHD1',
'EIF1',
'ETS2',
'F2RL1',
'F3',
'FJX1',
'FOS',
'FOSB',
'FOSL1',
'FOSL2',
'FUT4',
'G0S2',
'GADD45A',
'GADD45B',
'GCH1',
'GEM',
'GFPT2',
'GPR183',
'HBEGF',
'HES1',
'ICAM1',
'ICOSLG',
'ID2',
'IER2',
'IER3',
'IER5',
'IFIH1',
'IFIT2',
'IFNGR2',
'IL12B',
'IL15RA',
'IL18',
'IL1A',
'IL1B',
'IL23A',
'IL6',
'IL6ST',
'IL7R',
'INHBA',
'IRF1',
'IRS2',
'JAG1',
'JUN',
'JUNB',
'KDM6B',
'KLF10',
'KLF2',
'KLF4',
'KLF6',
'KLF9',
'KYNU',
'LAMB3',
'LDLR',
'LIF',
'LITAF',
'MAFF',
'MAP2K3',
'MAP3K8',
'MARCKS',
'MCL1',
'MSC',
'MXD1',
'MYC',
'NAMPT',
'NFAT5',
'NFE2L2',
'NFIL3',
'NFKB1',
'NFKB2',
'NFKBIA',
'NFKBIE',
'NINJ1',
'NR4A1',
'NR4A2',
'NR4A3',
'OLR1',
'PANX1',
'PDE4B',
'PDLIM5',
'PER1',
'PFKFB3',
'PHLDA1',
'PHLDA2',
'PLAU',
'PLAUR',
'PLEK',
'PLK2',
'PLPP3',
'PMEPA1',
'PNRC1',
'PPP1R15A',
'PTGER4',
'PTGS2',
'PTPRE',
'PTX3',
'RCAN1',
'REL',
'RELA',
'RELB',
'RHOB',
'RIGI',
'RIPK2',
'RNF19B',
'SAT1',
'SDC4',
'SERPINB2',
'SERPINB8',
'SERPINE1',
'SGK1',
'SIK1',
'SLC16A6',
'SLC2A3',
'SLC2A6',
'SMAD3',
'SNN',
'SOCS3',
'SOD2',
'SPHK1',
'SPSB1',
'SQSTM1',
'STAT5A',
'TANK',
'TAP1',
'TGIF1',
'TIPARP',
'TLR2',
'TNC',
'TNF',
'TNFAIP2',
'TNFAIP3',
'TNFAIP6',
'TNFAIP8',
'TNFRSF9',
'TNFSF9',
'TNIP1',
'TNIP2',
'TRAF1',
'TRIB1',
'TRIP10',
'TSC22D1',
'TUBB2A',
'VEGFA',
'YRDC',
'ZBTB10',
'ZC3H12A',
'ZFP36'},
'HALLMARK_UNFOLDED_PROTEIN_RESPONSE': {'ALDH18A1',
'ARFGAP1',
'ASNS',
'ATF3',
'ATF4',
'ATF6',
'ATP6V0D1',
'BAG3',
'BANF1',
'CALR',
'CCL2',
'CEBPB',
'CEBPG',
'CHAC1',
'CKS1B',
'CNOT2',
'CNOT4',
'CNOT6',
'CXXC1',
'DCP1A',
'DCP2',
'DCTN1',
'DDIT4',
'DDX10',
'DKC1',
'DNAJA4',
'DNAJB9',
'DNAJC3',
'EDC4',
'EDEM1',
'EEF2',
'EIF2AK3',
'EIF2S1',
'EIF4A1',
'EIF4A2',
'EIF4A3',
'EIF4E',
'EIF4EBP1',
'EIF4G1',
'ERN1',
'ERO1A',
'EXOC2',
'EXOSC1',
'EXOSC10',
'EXOSC2',
'EXOSC4',
'EXOSC5',
'EXOSC9',
'FKBP14',
'FUS',
'GEMIN4',
'GOSR2',
'H2AX',
'HERPUD1',
'HSP90B1',
'HSPA5',
'HSPA9',
'HYOU1',
'IARS1',
'IFIT1',
'IGFBP1',
'IMP3',
'KDELR3',
'KHSRP',
'KIF5B',
'LSM1',
'LSM4',
'MTHFD2',
'MTREX',
'NABP1',
'NFYA',
'NFYB',
'NHP2',
'NOLC1',
'NOP14',
'NOP56',
'NPM1',
'PAIP1',
'PARN',
'PDIA5',
'PDIA6',
'POP4',
'PREB',
'PSAT1',
'RPS14',
'RRP9',
'SDAD1',
'SEC11A',
'SEC31A',
'SERP1',
'SHC1',
'SKIC3',
'SLC1A4',
'SLC30A5',
'SLC7A5',
'SPCS1',
'SPCS3',
'SRPRA',
'SRPRB',
'SSR1',
'STC2',
'TARS1',
'TATDN2',
'TSPYL2',
'TUBB2A',
'VEGFA',
'WFS1',
'WIPI1',
'XBP1',
'XPOT',
'YIF1A',
'YWHAZ',
'ZBTB17'},
'HALLMARK_UV_RESPONSE_DN': {'ABCC1',
'ACVR2A',
'ADD3',
'ADGRL2',
'ADORA2B',
'AGGF1',
'AKT3',
'AMPH',
'ANXA2',
'ANXA4',
'APBB2',
'ARHGEF9',
'ATP2B1',
'ATP2B4',
'ATP2C1',
'ATRN',
'ATRX',
'ATXN1',
'BCKDHB',
'BDNF',
'BHLHE40',
'BMPR1A',
'CACNA1A',
'CAP2',
'CAV1',
'CCN1',
'CDC42BPA',
'CDK13',
'CDKN1B',
'CDON',
'CELF2',
'CITED2',
'COL11A1',
'COL1A1',
'COL1A2',
'COL3A1',
'COL5A2',
'DAB2',
'DBP',
'DDAH1',
'DLC1',
'DLG1',
'DMAC2L',
'DUSP1',
'DYRK1A',
'EFEMP1',
'ERBB2',
'F3',
'FBLN5',
'FHL2',
'FYN',
'FZD2',
'GCNT1',
'GJA1',
'GRK5',
'HAS2',
'ICA1',
'ID1',
'IGF1R',
'IGFBP5',
'INPP4B',
'INSIG1',
'IRS1',
'ITGB3',
'KALRN',
'KCNMA1',
'KIT',
'LAMC1',
'LDLR',
'LPAR1',
'LTBP1',
'MAGI2',
'MAP1B',
'MAP2K5',
'MAPK14',
'MET',
'MGLL',
'MGMT',
'MIOS',
'MMP16',
'MRPS31',
'MT1E',
'MTA1',
'MYC',
'NEK7',
'NFIB',
'NFKB1',
'NIPBL',
'NOTCH2',
'NR1D2',
'NR3C1',
'NRP1',
'PDGFRB',
'PDLIM5',
'PEX14',
'PHF3',
'PIAS3',
'PIK3CD',
'PIK3R3',
'PLCB4',
'PLPP3',
'PMP22',
'PPARG',
'PRDM2',
'PRKAR2B',
'PRKCA',
'PRKCE',
'PTEN',
'PTGFR',
'PTPN21',
'PTPRM',
'RASA2',
'RBPMS',
'RGS4',
'RND3',
'RUNX1',
'RXRA',
'SCAF8',
'SCHIP1',
'SCN8A',
'SDC2',
'SERPINE1',
'SFMBT1',
'SIPA1L1',
'SLC22A18',
'SLC7A1',
'SMAD3',
'SMAD7',
'SNAI2',
'SPOP',
'SRI',
'SYNE1',
'SYNJ2',
'TENT4A',
'TFPI',
'TGFBR2',
'TGFBR3',
'TJP1',
'TOGARAM1',
'VAV2',
'VLDLR',
'WDR37',
'YTHDC1',
'ZMIZ1'},
'HALLMARK_UV_RESPONSE_UP': {'ABCB1',
'ACAA1',
'AGO2',
'ALAS1',
'ALDOA',
'AMD1',
'AP2S1',
'APOM',
'AQP3',
'ARRB2',
'ASNS',
'ATF3',
'ATP6V1C1',
'ATP6V1F',
'BAK1',
'BCL2L11',
'BID',
'BMP2',
'BSG',
'BTG1',
'BTG2',
'BTG3',
'C4BPB',
'CA2',
'CASP3',
'CCK',
'CCND3',
'CCNE1',
'CDC34',
'CDC5L',
'CDK2',
'CDKN1C',
'CDKN2B',
'CDO1',
'CEBPG',
'CHKA',
'CHRNA5',
'CLCN2',
'CLTB',
'CNP',
'COL2A1',
'CREG1',
'CTSV',
'CXCL2',
'CYB5B',
'CYB5R1',
'CYP1A1',
'DDX21',
'DGAT1',
'DLG4',
'DNAJA1',
'DNAJB1',
'E2F5',
'EIF2S3',
'EIF5',
'ENO2',
'EPCAM',
'EPHX1',
'FEN1',
'FGF18',
'FKBP4',
'FMO1',
'FOS',
'FOSB',
'FURIN',
'GAL',
'GCH1',
'GGH',
'GLS',
'GPX3',
'GRINA',
'GRPEL1',
'H2AX',
'HLA-F',
'HMOX1',
'HNRNPU',
'HSPA13',
'HSPA2',
'HTR7',
'HYAL2',
'ICAM1',
'IGFBP2',
'IL6',
'IL6ST',
'IRF1',
'JUNB',
'KCNH2',
'KLHDC3',
'LHX2',
'LYN',
'MAOA',
'MAPK8IP2',
'MARK2',
'MGAT1',
'MMP14',
'MRPL23',
'MSX1',
'NAT1',
'NFKBIA',
'NKX2-5',
'NPTX2',
'NPTXR',
'NR4A1',
'NTRK3',
'NUP58',
'NXF1',
'OLFM1',
'ONECUT1',
'PARP2',
'PDAP1',
'PDLIM3',
'PLCL1',
'POLE3',
'POLG2',
'POLR2H',
'PPAT',
'PPIF',
'PPP1R2',
'PPT1',
'PRKACA',
'PRKCD',
'PRPF3',
'PSMC3',
'PTPRD',
'RAB27A',
'RASGRP1',
'RET',
'RFC4',
'RHOB',
'RPN1',
'RRAD',
'RXRB',
'SELENOW',
'SHOX2',
'SIGMAR1',
'SLC25A4',
'SLC6A12',
'SLC6A8',
'SOD2',
'SPR',
'SQSTM1',
'STARD3',
'STIP1',
'STK25',
'SULT1A1',
'TACR3',
'TAP1',
'TARS1',
'TCHH',
'TFRC',
'TGFBRAP1',
'TMBIM6',
'TST',
'TUBA4A',
'TYRO3',
'UROD',
'WIZ',
'YKT6'},
'HALLMARK_WNT_BETA_CATENIN_SIGNALING': {'ADAM17',
'AXIN1',
'AXIN2',
'CCND2',
'CSNK1E',
'CTNNB1',
'CUL1',
'DKK1',
'DKK4',
'DLL1',
'DVL2',
'FRAT1',
'FZD1',
'FZD8',
'GNAI1',
'HDAC11',
'HDAC2',
'HDAC5',
'HEY1',
'HEY2',
'JAG1',
'JAG2',
'KAT2A',
'LEF1',
'MAML1',
'MYC',
'NCOR2',
'NCSTN',
'NKD1',
'NOTCH1',
'NOTCH4',
'NUMB',
'PPARD',
'PSEN2',
'PTCH1',
'RBPJ',
'SKP2',
'TCF7',
'TP53',
'WNT1',
'WNT5B',
'WNT6'},
'HALLMARK_XENOBIOTIC_METABOLISM': {'ABCC2',
'ABCC3',
'ABCD2',
'ABHD6',
'ACO2',
'ACOX1',
'ACOX2',
'ACOX3',
'ACP1',
'ACP2',
'ACSM1',
'ADH1C',
'ADH5',
'ADH7',
'AHCY',
'AKR1C2',
'AKR1C3',
'ALAS1',
'ALDH2',
'ALDH3A1',
'ALDH9A1',
'ANGPTL3',
'AOX1',
'AP4B1',
'APOE',
'AQP9',
'ARG1',
'ARG2',
'ARPP19',
'ASL',
'ATOH8',
'ATP2A2',
'BCAR1',
'BCAT1',
'BLVRB',
'BPHL',
'CA2',
'CASP6',
'CAT',
'CBR1',
'CCL25',
'CD36',
'CDA',
'CDO1',
'CES1',
'CFB',
'CNDP2',
'COMT',
'CROT',
'CRP',
'CSAD',
'CYB5A',
'CYFIP2',
'CYP17A1',
'CYP1A1',
'CYP1A2',
'CYP26A1',
'CYP27A1',
'CYP2C18',
'CYP2E1',
'CYP2J2',
'CYP2S1',
'CYP4F2',
'DCXR',
'DDAH2',
'DDC',
'DDT',
'DHPS',
'DHRS1',
'DHRS7',
'ECH1',
'ELOVL5',
'ENPEP',
'ENTPD5',
'EPHA2',
'EPHX1',
'ESR1',
'ETFDH',
'ETS2',
'F10',
'F11',
'FABP1',
'FAH',
'FAS',
'FBLN1',
'FBP1',
'FETUB',
'FMO1',
'FMO3',
'G6PC1',
'GABARAPL1',
'GAD1',
'GART',
'GCH1',
'GCKR',
'GCLC',
'GCNT2',
'GNMT',
'GSR',
'GSS',
'GSTA3',
'GSTM4',
'GSTO1',
'GSTT2',
'HACL1',
'HES6',
'HGFAC',
'HMOX1',
'HNF4A',
'HPRT1',
'HRG',
'HSD11B1',
'HSD17B2',
'ID2',
'IDH1',
'IGF1',
'IGFBP1',
'IGFBP4',
'IL1R1',
'IRF8',
'ITIH1',
'ITIH4',
'JUP',
'KARS1',
'KYNU',
'LCAT',
'LEAP2',
'LONP1',
'LPIN2',
'MAN1A1',
'MAOA',
'MARCHF6',
'MBL2',
'MCCC2',
'MPP2',
'MT2A',
'MTHFD1',
'NDRG2',
'NFS1',
'NINJ1',
'NMT1',
'NPC1',
'NQO1',
'PAPSS2',
'PC',
'PDK4',
'PDLIM5',
'PEMT',
'PGD',
'PGRMC1',
'PINK1',
'PLG',
'PMM1',
'POR',
'PPARD',
'PROS1',
'PSMB10',
'PTGDS',
'PTGES',
'PTGES3',
'PTGR1',
'PTS',
'PYCR1',
'RAP1GAP',
'RBP4',
'REG1A',
'RETSAT',
'SAR1B',
'SERPINA6',
'SERPINE1',
'SERTAD1',
'SHMT2',
'SLC12A4',
'SLC1A5',
'SLC22A1',
'SLC35B1',
'SLC35D1',
'SLC46A3',
'SLC6A12',
'SLC6A6',
'SMOX',
'SPINT2',
'SSR3',
'TAT',
'TDO2',
'TGFB2',
'TKFC',
'TMBIM6',
'TMEM176B',
'TMEM97',
'TNFRSF1A',
'TPST1',
'TTPA',
'TYR',
'UGDH',
'UPB1',
'UPP1',
'VNN1',
'VTN',
'XDH'}}
Step 2: Calculate Fisher's Exact Test for Enrichment¶
In [9]:
Copied!
# Container for results
results = []
# Iterate over each module
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
# Check if module_genes_in_expr is empty to avoid issues
if len(module_genes_in_expr) == 0:
continue
# Iterate over each gene set in the GMT file
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = module_genes_in_expr.intersection(gene_set_genes)
non_overlap_module_genes = module_genes_in_expr.difference(gene_set_genes)
non_overlap_gene_set_genes = gene_set_genes.difference(module_genes_in_expr)
# Calculate the contingency table
a = len(overlap_genes)
b = len(non_overlap_module_genes)
c = len(non_overlap_gene_set_genes)
d = len(set(datExpr.columns)) - (a + b + c) # Adjust d to only consider genes in datExpr
# Ensure all values in the contingency table are non-negative
if a < 0 or b < 0 or c < 0 or d < 0:
continue
# Perform Fisher's exact test
odds_ratio, p_value = fisher_exact([[a, b], [c, d]], alternative='two-sided')
results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': a,
'Odds Ratio': odds_ratio,
'P-value': p_value
})
# Container for results
results = []
# Iterate over each module
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
# Check if module_genes_in_expr is empty to avoid issues
if len(module_genes_in_expr) == 0:
continue
# Iterate over each gene set in the GMT file
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = module_genes_in_expr.intersection(gene_set_genes)
non_overlap_module_genes = module_genes_in_expr.difference(gene_set_genes)
non_overlap_gene_set_genes = gene_set_genes.difference(module_genes_in_expr)
# Calculate the contingency table
a = len(overlap_genes)
b = len(non_overlap_module_genes)
c = len(non_overlap_gene_set_genes)
d = len(set(datExpr.columns)) - (a + b + c) # Adjust d to only consider genes in datExpr
# Ensure all values in the contingency table are non-negative
if a < 0 or b < 0 or c < 0 or d < 0:
continue
# Perform Fisher's exact test
odds_ratio, p_value = fisher_exact([[a, b], [c, d]], alternative='two-sided')
results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': a,
'Odds Ratio': odds_ratio,
'P-value': p_value
})
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# Convert results to DataFrame for further analysis
results_df = pd.DataFrame(results)
# Adjust p-values for multiple testing
results_df['Adjusted P-value'] = multipletests(results_df['P-value'], method='fdr_bh')[1]
# Display results
print(results_df)
# Convert results to DataFrame for further analysis
results_df = pd.DataFrame(results)
# Adjust p-values for multiple testing
results_df['Adjusted P-value'] = multipletests(results_df['P-value'], method='fdr_bh')[1]
# Display results
print(results_df)
Module Gene Set Overlap Count \
0 Module_1 HALLMARK_ADIPOGENESIS 0
1 Module_1 HALLMARK_ALLOGRAFT_REJECTION 0
2 Module_1 HALLMARK_ANDROGEN_RESPONSE 0
3 Module_1 HALLMARK_ANGIOGENESIS 0
4 Module_1 HALLMARK_APICAL_JUNCTION 1
.. ... ... ...
895 Module_18 HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0
896 Module_18 HALLMARK_UV_RESPONSE_DN 0
897 Module_18 HALLMARK_UV_RESPONSE_UP 0
898 Module_18 HALLMARK_WNT_BETA_CATENIN_SIGNALING 0
899 Module_18 HALLMARK_XENOBIOTIC_METABOLISM 0
Odds Ratio P-value Adjusted P-value
0 0.000000 1.776694e-07 0.000011
1 0.000000 1.776694e-07 0.000011
2 0.000000 7.106383e-04 0.018274
3 0.000000 1.701923e-01 0.495706
4 0.053237 3.131992e-06 0.000141
.. ... ... ...
895 0.000000 1.000000e+00 1.000000
896 0.000000 1.000000e+00 1.000000
897 0.000000 1.000000e+00 1.000000
898 0.000000 1.000000e+00 1.000000
899 0.000000 1.000000e+00 1.000000
[900 rows x 6 columns]
Let's focus on one module for the purpose of the enrichment analysis:
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# Filter for Module 1 and sort by overlap count
module_1_results = results_df[results_df['Module'] == 'Module_1']
top_10_enriched_gene_sets = module_1_results.sort_values(by='Overlap Count', ascending=False).head(10)
print(top_10_enriched_gene_sets)
# Filter for Module 1 and sort by overlap count
module_1_results = results_df[results_df['Module'] == 'Module_1']
top_10_enriched_gene_sets = module_1_results.sort_values(by='Overlap Count', ascending=False).head(10)
print(top_10_enriched_gene_sets)
Module Gene Set Overlap Count \
15 Module_1 HALLMARK_ESTROGEN_RESPONSE_LATE 3
13 Module_1 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 2
33 Module_1 HALLMARK_MYOGENESIS 2
27 Module_1 HALLMARK_KRAS_SIGNALING_DN 2
49 Module_1 HALLMARK_XENOBIOTIC_METABOLISM 2
5 Module_1 HALLMARK_APICAL_SURFACE 1
21 Module_1 HALLMARK_HYPOXIA 1
28 Module_1 HALLMARK_KRAS_SIGNALING_UP 1
9 Module_1 HALLMARK_COAGULATION 1
42 Module_1 HALLMARK_SPERMATOGENESIS 1
Odds Ratio P-value Adjusted P-value
15 0.166604 0.000164 0.004928
13 0.108734 0.000034 0.001084
33 0.108734 0.000034 0.001084
27 0.108734 0.000034 0.001084
49 0.108734 0.000034 0.001084
5 0.298955 0.359027 0.895178
21 0.053237 0.000003 0.000141
28 0.053237 0.000003 0.000141
9 0.083889 0.000467 0.012366
42 0.086091 0.000775 0.018855
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#Extract data for plotting (top 10 pathways with highest overlap count)
top_10_enriched_gene_sets
y_labels = top_10_enriched_gene_sets['Gene Set']
x = top_10_enriched_gene_sets['Odds Ratio']
sizes = top_10_enriched_gene_sets['Overlap Count'] * 20
p_values = top_10_enriched_gene_sets['P-value']
adjusted_p_values = top_10_enriched_gene_sets['Adjusted P-value']
#Extract data for plotting (top 10 pathways with highest overlap count)
top_10_enriched_gene_sets
y_labels = top_10_enriched_gene_sets['Gene Set']
x = top_10_enriched_gene_sets['Odds Ratio']
sizes = top_10_enriched_gene_sets['Overlap Count'] * 20
p_values = top_10_enriched_gene_sets['P-value']
adjusted_p_values = top_10_enriched_gene_sets['Adjusted P-value']
Step 3: Visualise Enriched Pathways¶
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# Plot the scatter plot for the top 10 pathways
plt.figure(figsize=(12, 8))
# Main scatter plot
sc = plt.scatter(x, range(10), s=sizes, c=-adjusted_p_values, cmap='viridis', alpha=0.7)
# Set labels and title
plt.yticks(range(10), y_labels) # Set y-axis labels to pathway names
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Gene Sets')
# Add a legend for dot sizes (overlap count) outside the plot
handles, labels = sc.legend_elements(prop="sizes", alpha=0.6)
legend_labels = [f'Overlap Count: {int(float(label.split("{")[1].split("}")[0]) // 20)}' for label in labels]
legend = plt.legend(handles, legend_labels, loc="center left", bbox_to_anchor=(1.3, 0.5), title="Overlap", frameon=False)
# Add colorbar
cbar = plt.colorbar(sc, shrink=0.2) # Shrink colorbar size
cbar.ax.xaxis.set_label_position('top')
cbar.ax.set_title('Adj.pval', loc='left')
# Adjust layout to prevent overlap between legends
plt.subplots_adjust(right=0.75) # Adjust the right margin to make space for the legends
# Show the plot
plt.grid(True)
plt.tight_layout() # Adjust layout to prevent clipping of labels
plt.show()
# Plot the scatter plot for the top 10 pathways
plt.figure(figsize=(12, 8))
# Main scatter plot
sc = plt.scatter(x, range(10), s=sizes, c=-adjusted_p_values, cmap='viridis', alpha=0.7)
# Set labels and title
plt.yticks(range(10), y_labels) # Set y-axis labels to pathway names
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Gene Sets')
# Add a legend for dot sizes (overlap count) outside the plot
handles, labels = sc.legend_elements(prop="sizes", alpha=0.6)
legend_labels = [f'Overlap Count: {int(float(label.split("{")[1].split("}")[0]) // 20)}' for label in labels]
legend = plt.legend(handles, legend_labels, loc="center left", bbox_to_anchor=(1.3, 0.5), title="Overlap", frameon=False)
# Add colorbar
cbar = plt.colorbar(sc, shrink=0.2) # Shrink colorbar size
cbar.ax.xaxis.set_label_position('top')
cbar.ax.set_title('Adj.pval', loc='left')
# Adjust layout to prevent overlap between legends
plt.subplots_adjust(right=0.75) # Adjust the right margin to make space for the legends
# Show the plot
plt.grid(True)
plt.tight_layout() # Adjust layout to prevent clipping of labels
plt.show()
KEGG Pathway Enrichment Analysis using Gseapy¶
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kegg = gp.get_library(name='KEGG_2016', organism='Human')
kegg = gp.get_library(name='KEGG_2016', organism='Human')
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kegg
kegg
Out[15]:
{'Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Homo sapiens hsa00532': ['CSGALNACT2',
'CSGALNACT1',
'CHST7',
'CHPF2',
'CHPF',
'XYLT1',
'B3GAT3',
'XYLT2',
'B3GALT6',
'DSE',
'UST',
'CHST12',
'CHSY3',
'CHST13',
'CHSY1',
'CHST11',
'CHST14',
'CHST15',
'B4GALT7',
'CHST3'],
'Glycosaminoglycan biosynthesis - heparan sulfate / heparin Homo sapiens hsa00534': ['HS3ST3A1',
'HS3ST1',
'HS3ST3B1',
'XYLT1',
'B3GAT3',
'GLCE',
'XYLT2',
'B3GALT6',
'HS6ST1',
'HS6ST2',
'HS3ST5',
'HS2ST1',
'HS6ST3',
'HS3ST2',
'EXT1',
'NDST3',
'EXT2',
'EXTL1',
'NDST2',
'NDST1',
'EXTL3',
'EXTL2',
'NDST4',
'B4GALT7'],
'Glycosylphosphatidylinositol(GPI)-anchor biosynthesis Homo sapiens hsa00563': ['GPLD1',
'DPM2',
'PIGC',
'PIGF',
'PIGB',
'PIGA',
'PIGL',
'PIGK',
'PIGN',
'PIGM',
'PIGH',
'PIGG',
'PIGT',
'PIGS',
'PGAP1',
'PIGV',
'PIGU',
'PIGP',
'PIGO',
'PIGQ',
'GPAA1',
'PIGX',
'PIGW',
'PIGZ',
'PIGY'],
'Steroid biosynthesis Homo sapiens hsa00100': ['CYP51A1',
'FAXDC2',
'CEL',
'LSS',
'DHCR24',
'MSMO1',
'HSD17B7',
'TM7SF2',
'LIPA',
'SQLE',
'CYP27B1',
'NSDHL',
'EBP',
'CYP24A1',
'SOAT2',
'CYP2R1',
'SOAT1',
'SC5D',
'DHCR7',
'FDFT1'],
'SNARE interactions in vesicular transport Homo sapiens hsa04130': ['STX8',
'BET1L',
'VAMP7',
'VAMP8',
'VAMP1',
'VAMP2',
'VAMP5',
'SEC22B',
'STX1B',
'VAMP3',
'STX1A',
'VAMP4',
'BET1',
'STX16',
'GOSR1',
'STX18',
'STX17',
'SNAP23',
'GOSR2',
'STX19',
'STX10',
'USE1',
'STX11',
'VTI1B',
'STX7',
'VTI1A',
'STX6',
'YKT6',
'STX5',
'BNIP1',
'STX4',
'STX3',
'SNAP29',
'STX2'],
'Protein export Homo sapiens hsa03060': ['SRP19',
'SRP9',
'SEC11A',
'HSPA5',
'SRPR',
'SRP68',
'SRP14',
'OXA1L',
'SEC61A2',
'IMMP1L',
'SPCS3',
'IMMP2L',
'SRP72',
'SPCS2',
'SPCS1',
'SEC61A1',
'SEC61G',
'SRP54',
'SEC61B',
'SRPRB',
'SEC11C',
'SEC63',
'SEC62'],
'Protein processing in endoplasmic reticulum Homo sapiens hsa04141': ['SEC24A',
'SEC24C',
'SEC24B',
'HSPA1L',
'FBXO2',
'AMFR',
'MOGS',
'YOD1',
'RBX1',
'ERN1',
'NSFL1C',
'MAPK10',
'DNAJB11',
'DNAJB12',
'HSPA1A',
'BAX',
'RNF185',
'ERP29',
'PREB',
'SEC24D',
'PLAA',
'HSPA1B',
'PARK2',
'ATF6B',
'UBE2D3',
'TUSC3',
'UBE2D4',
'PPP1R15A',
'UBE2D1',
'UBE2D2',
'LOC102724652',
'RRBP1',
'RNF5',
'HSP90B1',
'CAPN1',
'CAPN2',
'MAP3K5',
'PDIA4',
'PDIA3',
'XBP1',
'WFS1',
'LMAN1L',
'EDEM1',
'EDEM2',
'EDEM3',
'TRAF2',
'EIF2S1',
'PDIA6',
'CKAP4',
'NPLOC4',
'DDOST',
'DNAJC10',
'STT3B',
'HYOU1',
'STT3A',
'CRYAB',
'ATF6',
'ATF4',
'CRYAA',
'HSPA4L',
'ERO1LB',
'VCP',
'NGLY1',
'CUL1',
'SEL1L2',
'UBE2J1',
'HSPBP1',
'UBE2J2',
'HSPH1',
'ATXN3L',
'BAG1',
'BAG2',
'TXNDC5',
'SIL1',
'SEC31A',
'SEC63',
'SEC62',
'SKP1',
'MAP2K7',
'SEC31B',
'HSP90AA1',
'SEC13',
'HSPA6',
'HSPA5',
'EIF2AK2',
'SSR3',
'HSPA8',
'EIF2AK1',
'SSR4',
'EIF2AK4',
'HSPA2',
'EIF2AK3',
'UBE2G2',
'RAD23B',
'RAD23A',
'UBE2G1',
'MARCH6',
'DNAJC3',
'DNAJC1',
'UBQLNL',
'DNAJC5',
'BCL2',
'CALR',
'VIMP',
'NFE2L2',
'UFD1L',
'TRAM1',
'SAR1A',
'SAR1B',
'SEL1L',
'RPN1',
'RPN2',
'DNAJB2',
'ATXN3',
'DNAJB1',
'CASP12',
'ERLEC1',
'SEC61G',
'SSR1',
'SEC61B',
'SSR2',
'DNAJC5G',
'MAN1A2',
'MAN1A1',
'UBXN6',
'MBTPS1',
'MBTPS2',
'BCAP31',
'DNAJC5B',
'UBE2E2',
'SYVN1',
'UBE2E3',
'UBE4B',
'UBE2E1',
'SVIP',
'DNAJA2',
'DNAJA1',
'DAD1',
'P4HB',
'CANX',
'MAN1B1',
'DDIT3',
'STUB1',
'SEC23B',
'SEC23A',
'HSP90AB1',
'PRKCSH',
'DERL2',
'DERL3',
'DERL1',
'HERPUD1',
'ERO1L',
'LMAN1',
'LMAN2',
'SEC61A2',
'MAPK9',
'MAPK8',
'GANAB',
'OS9',
'SEC61A1',
'UBQLN2',
'UBQLN1',
'MAN1C1',
'BAK1',
'FBXO6',
'UGGT2',
'UGGT1',
'UBQLN4',
'UBQLN3'],
'N-Glycan biosynthesis Homo sapiens hsa00510': ['ALG14',
'MOGS',
'DOLPP1',
'ALG13',
'ALG12',
'ALG11',
'ALG10',
'DPM1',
'DPM2',
'DPM3',
'ALG10B',
'B4GALT3',
'DPAGT1',
'B4GALT1',
'B4GALT2',
'TUSC3',
'RPN1',
'RPN2',
'FUT8',
'MGAT5B',
'MAN1A2',
'MAN1A1',
'ALG9',
'ST6GAL2',
'ALG8',
'ST6GAL1',
'ALG5',
'ALG6',
'ALG3',
'DOLK',
'ALG1',
'ALG2',
'MGAT4D',
'DDOST',
'MGAT4A',
'MGAT4B',
'DAD1',
'MGAT4C',
'STT3B',
'MAN1B1',
'STT3A',
'GANAB',
'MAN2A2',
'MGAT5',
'MAN1C1',
'MAN2A1',
'MGAT2',
'MGAT3',
'MGAT1'],
'Other types of O-glycan biosynthesis Homo sapiens hsa00514': ['ST6GAL2',
'ST6GAL1',
'B3GAT2',
'B3GAT1',
'B3GALT4',
'POMGNT1',
'B3GALTL',
'MFNG',
'EOGT',
'OGT',
'B4GALT3',
'POGLUT1',
'B4GALT1',
'B4GALT2',
'POMT1',
'POMT2',
'GXYLT2',
'GXYLT1',
'RFNG',
'PLOD3',
'FUT4',
'FUT7',
'LFNG',
'FUT9',
'POFUT1',
'MGAT5B',
'POFUT2',
'CHST10',
'COLGALT1',
'COLGALT2',
'ST3GAL3'],
'Glycosaminoglycan biosynthesis - keratan sulfate Homo sapiens hsa00533': ['B4GALT3',
'B4GALT4',
'B4GALT1',
'B4GALT2',
'FUT8',
'B3GNT7',
'CHST1',
'CHST2',
'B3GNT2',
'B3GNT1',
'ST3GAL1',
'ST3GAL2',
'CHST6',
'ST3GAL3',
'CHST4'],
'Glycosphingolipid biosynthesis - lacto and neolacto series Homo sapiens hsa00601': ['ST8SIA1',
'B3GALT5',
'B3GNT5',
'B3GNT4',
'B3GNT3',
'B3GNT2',
'B3GNT1',
'B4GALT3',
'B4GALT4',
'B4GALT1',
'B4GALT2',
'GCNT2',
'FUT1',
'FUT3',
'FUT2',
'ABO',
'FUT5',
'FUT4',
'FUT7',
'FUT6',
'FUT9',
'B3GALT1',
'B3GALT2',
'ST3GAL6',
'ST3GAL3',
'ST3GAL4'],
'Glycosphingolipid biosynthesis - globo series Homo sapiens hsa00603': ['B3GALNT1',
'ST8SIA1',
'HEXA',
'HEXB',
'B3GALT5',
'NAGA',
'FUT1',
'FUT2',
'GBGT1',
'FUT9',
'GLA',
'ST3GAL1',
'A4GALT',
'ST3GAL2'],
'Glycosphingolipid biosynthesis - ganglio series Homo sapiens hsa00604': ['ST6GALNAC3',
'ST8SIA1',
'SLC33A1',
'HEXA',
'HEXB',
'B3GALT4',
'GLB1',
'ST8SIA5',
'ST3GAL5',
'B4GALNT1',
'ST6GALNAC4',
'ST3GAL1',
'ST6GALNAC5',
'ST3GAL2',
'ST6GALNAC6'],
'Mucin type O-Glycan biosynthesis Homo sapiens hsa00512': ['GALNT8',
'GALNT7',
'GALNT6',
'GALNT5',
'GALNT4',
'GALNT3',
'C1GALT1',
'GALNT2',
'GALNT1',
'WBSCR17',
'B3GNT6',
'GALNTL6',
'GALNTL5',
'POC1B-GALNT4',
'B4GALT5',
'GALNT13',
'GALNT12',
'ST6GALNAC1',
'GALNT15',
'GALNT14',
'GALNT16',
'GCNT1',
'GALNT18',
'GALNT11',
'GALNT10',
'C1GALT1C1',
'GCNT3',
'GCNT4',
'ST3GAL1',
'ST3GAL2',
'GALNT9'],
'Sphingolipid metabolism Homo sapiens hsa00600': ['CERS4',
'ARSA',
'CERS5',
'CERS6',
'SPHK2',
'SPHK1',
'SGPP2',
'SGPP1',
'ACER3',
'ACER2',
'GALC',
'GLB1',
'ACER1',
'PPAP2A',
'PPAP2C',
'PPAP2B',
'DEGS2',
'GLA',
'DEGS1',
'CERS1',
'CERS2',
'CERS3',
'B4GALT6',
'ASAH2',
'GAL3ST1',
'SGMS2',
'GBA',
'SGMS1',
'CERK',
'GBA2',
'ASAH1',
'SMPD4',
'NEU3',
'SMPD3',
'NEU4',
'SPTLC1',
'UGCG',
'UGT8',
'SPTLC2',
'SGPL1',
'SPTLC3',
'KDSR',
'SMPD2',
'NEU1',
'SMPD1',
'NEU2',
'ENPP7'],
'Other glycan degradation Homo sapiens hsa00511': ['FUCA1',
'MANBA',
'HEXA',
'GBA',
'FUCA2',
'HEXB',
'GBA2',
'HEXDC',
'NEU3',
'NEU4',
'GLB1',
'NEU1',
'NEU2',
'MAN2C1',
'AGA',
'MAN2B2',
'MAN2B1',
'ENGASE'],
'Glycosaminoglycan degradation Homo sapiens hsa00531': ['HGSNAT',
'ARSB',
'IDUA',
'HEXA',
'HEXB',
'GNS',
'HPSE2',
'SGSH',
'GALNS',
'SPAM1',
'GLB1',
'HYAL1',
'NAGLU',
'HYAL2',
'IDS',
'HYAL3',
'HYAL4',
'HPSE',
'GUSB'],
'Lysosome Homo sapiens hsa04142': ['CD164',
'ENTPD4',
'AP1S1',
'AP1B1',
'CTNS',
'GALNS',
'GLA',
'CD68',
'ATP6V0D1',
'IDUA',
'ASAH1',
'GGA1',
'GGA3',
'AP3M2',
'GGA2',
'LAPTM4B',
'GNPTAB',
'LAPTM4A',
'LAMP2',
'LAMP1',
'LAMP3',
'AP3M1',
'ARSA',
'ABCA2',
'IGF2R',
'ARSB',
'PSAPL1',
'ATP6V0C',
'NAPSA',
'MANBA',
'ATP6V0B',
'DNASE2B',
'SLC11A1',
'ATP6AP1',
'SLC11A2',
'M6PR',
'AP4B1',
'PPT2',
'LGMN',
'PPT1',
'TPP1',
'GNS',
'NAGPA',
'LIPA',
'AP1S3',
'AP1S2',
'ATP6V0A4',
'ARSG',
'ATP6V0A1',
'ATP6V1H',
'ATP6V0A2',
'HGSNAT',
'CTSB',
'CTSA',
'FUCA1',
'AP3B2',
'AP3B1',
'NPC1',
'SUMF1',
'NPC2',
'GNPTG',
'DNASE2',
'MAN2B1',
'CLTC',
'CTSZ',
'CLTB',
'CLTA',
'LITAF',
'ABCB9',
'CTSW',
'CTSV',
'CTSS',
'MFSD8',
'CTSO',
'PSAP',
'CLTCL1',
'IDS',
'NEU1',
'CTSL',
'CTSK',
'ACP5',
'CTSH',
'CTSG',
'AP4S1',
'AP1M1',
'CTSF',
'ACP2',
'CTSE',
'CTSD',
'AP1M2',
'CTSC',
'SORT1',
'GAA',
'NAGA',
'AP3D1',
'LAPTM5',
'MCOLN1',
'GALC',
'GLB1',
'PLA2G15',
'ATP6V0D2',
'SCARB2',
'CD63',
'HEXA',
'GBA',
'HEXB',
'TCIRG1',
'AP4E1',
'SGSH',
'CLN5',
'AP4M1',
'AP1G1',
'CLN3',
'HYAL1',
'NAGLU',
'AP1G2',
'GM2A',
'SMPD1',
'AP3S1',
'AGA',
'AP3S2',
'GUSB',
'SLC17A5'],
'Synaptic vesicle cycle Homo sapiens hsa04721': ['UNC13C',
'UNC13A',
'ATP6V1E1',
'UNC13B',
'DNM1',
'DNM2',
'DNM3',
'STX1B',
'STX1A',
'SNAP25',
'STXBP1',
'ATP6V0D1',
'NAPA',
'CLTC',
'CLTB',
'CLTA',
'CLTCL1',
'AP2S1',
'SLC18A1',
'ATP6V1E2',
'STX3',
'SLC18A2',
'STX2',
'SLC18A3',
'ATP6V1G1',
'NSF',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1G2',
'ATP6V0B',
'ATP6V1G3',
'ATP6V0E2',
'SLC32A1',
'SYT1',
'AP2B1',
'VAMP2',
'ATP6V0D2',
'ATP6V1B1',
'ATP6V1B2',
'ATP6V1A',
'RAB3A',
'ATP6V1D',
'CPLX1',
'CACNA1A',
'TCIRG1',
'CACNA1B',
'AP2A2',
'AP2A1',
'CPLX3',
'CPLX2',
'CPLX4',
'RIMS1',
'SLC17A6',
'SLC17A7',
'ATP6V0A4',
'SLC17A8',
'ATP6V1F',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'AP2M1',
'ATP6V0A2'],
'Collecting duct acid secretion Homo sapiens hsa04966': ['ATP6V1G1',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1G2',
'ATP6V1G3',
'ATP6V1E1',
'ATP6V0E2',
'ATP4B',
'ATP4A',
'ATP6V0D2',
'ATP6V1B1',
'ATP6V1B2',
'ATP6V1A',
'ATP6V1D',
'ATP6V0D1',
'TCIRG1',
'CLCNKB',
'SLC4A1',
'CA2',
'ATP6V0A4',
'ATP6V1F',
'ATP6V1E2',
'SLC12A7',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1C2',
'ATP6V0A2'],
'Vibrio cholerae infection Homo sapiens hsa05110': ['ATP6V1E1',
'SLC12A2',
'ATP6V0D1',
'KDELR1',
'ARF1',
'KDELR2',
'ADCY3',
'ADCY9',
'ACTB',
'MUC2',
'SEC61G',
'SEC61B',
'ATP6V1E2',
'PDIA4',
'ATP6V1G1',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1G2',
'ATP6V0B',
'ATP6V1G3',
'ATP6V0E2',
'ATP6AP1',
'PRKCA',
'TJP2',
'TJP1',
'KCNQ1',
'GNAS',
'KDELR3',
'ATP6V0D2',
'ATP6V1B1',
'CFTR',
'ATP6V1B2',
'ATP6V1A',
'ATP6V1D',
'ACTG1',
'TCIRG1',
'ERO1L',
'PRKACG',
'SEC61A2',
'SEC61A1',
'ATP6V0A4',
'PLCG1',
'PLCG2',
'PRKACB',
'ATP6V1F',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'PRKACA',
'ATP6V0A2'],
'Epithelial cell signaling in Helicobacter pylori infection Homo sapiens hsa05120': ['LYN',
'JUN',
'ATP6V1E1',
'PTPN11',
'MAPK13',
'MAPK14',
'MAPK11',
'NFKBIA',
'MAPK12',
'MAPK10',
'CXCL8',
'RELA',
'ATP6V0D1',
'IGSF5',
'NOD1',
'CXCL1',
'EGFR',
'PAK1',
'JAM2',
'CASP3',
'ATP6V1E2',
'JAM3',
'MAP2K4',
'ATP6V1G1',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1G2',
'ATP6V0B',
'ATP6V1G3',
'ATP6V0E2',
'CHUK',
'ATP6AP1',
'ADAM10',
'NFKB1',
'CDC42',
'TJP1',
'ADAM17',
'MET',
'HBEGF',
'MAP3K14',
'ATP6V0D2',
'ATP6V1B1',
'ATP6V1B2',
'ATP6V1A',
'SRC',
'ATP6V1D',
'TCIRG1',
'F11R',
'IKBKB',
'MAPK9',
'MAPK8',
'CXCR2',
'CXCR1',
'PTPRZ1',
'CCL5',
'ATP6V0A4',
'PLCG1',
'RAC1',
'PLCG2',
'CSK',
'IKBKG',
'ATP6V1F',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'GIT1',
'ATP6V0A2'],
'Rheumatoid arthritis Homo sapiens hsa05323': ['TGFB1',
'IL11',
'TGFB3',
'TGFB2',
'JUN',
'ATP6V1E1',
'MMP1',
'IL15',
'ANGPT1',
'CCL20',
'MMP3',
'IL18',
'VEGFA',
'IL1A',
'TLR2',
'IL1B',
'CXCL12',
'IL6',
'IL23A',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'TEK',
'CD28',
'TLR4',
'CXCL8',
'CD86',
'CCL3L1',
'ATP6V0D1',
'CSF2',
'TNFRSF11A',
'CSF1',
'CCL3L3',
'CD80',
'TNF',
'CXCL1',
'CXCL6',
'CXCL5',
'LOC102723407',
'CTSL',
'CTSK',
'ACP5',
'CTLA4',
'HLA-DOB',
'ATP6V1E2',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'ATP6V1G1',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1G2',
'HLA-DRB5',
'ATP6V0B',
'ATP6V1G3',
'ATP6V0E2',
'ATP6AP1',
'TNFSF13',
'FOS',
'IL17A',
'LTB',
'HLA-DPB1',
'HLA-DRB4',
'ATP6V0D2',
'HLA-DRB3',
'ATP6V1B1',
'HLA-DRB1',
'ATP6V1B2',
'ITGB2',
'ATP6V1A',
'FLT1',
'ATP6V1D',
'TCIRG1',
'ITGAL',
'ICAM1',
'TNFSF13B',
'HLA-DMB',
'CCL5',
'HLA-DPA1',
'TNFSF11',
'CCL3',
'ATP6V0A4',
'CCL2',
'ATP6V1F',
'HLA-DMA',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'ATP6V0A2'],
'Phagosome Homo sapiens hsa04145': ['DYNC2H1',
'ATP6V1E1',
'TAP2',
'TAP1',
'TUBA4A',
'TUBA8',
'DYNC1LI1',
'DYNC1LI2',
'MARCO',
'CD209',
'NCF1',
'CLEC4M',
'ATP6V0D1',
'STX18',
'TUBAL3',
'TUBB1',
'MPO',
'TUBA3C',
'STX12',
'ACTB',
'COMP',
'TUBB8',
'TUBA3E',
'TUBA3D',
'TUBB6',
'LAMP2',
'LAMP1',
'TUBB3',
'STX7',
'HLA-DOB',
'RILP',
'ATP6V1E2',
'HLA-DOA',
'MSR1',
'ATP6V0C',
'HLA-DRB5',
'ATP6V0B',
'ATP6AP1',
'HLA-C',
'M6PR',
'HLA-A',
'CYBB',
'HLA-B',
'CYBA',
'HLA-G',
'HLA-E',
'HLA-F',
'HGS',
'HLA-DRB4',
'RAB5A',
'HLA-DRB3',
'NOX1',
'RAB5B',
'ATP6V1B1',
'VAMP3',
'HLA-DRB1',
'NOX3',
'ATP6V1B2',
'ATP6V1A',
'ATP6V1D',
'NCF2',
'TFRC',
'NCF4',
'ACTG1',
'CORO1A',
'C3',
'ATP6V0A4',
'CD14',
'ATP6V1F',
'ATP6V1C1',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'ATP6V0A2',
'ITGA5',
'SFTPD',
'ITGA2',
'TUBB',
'TUBB2A',
'TLR2',
'FCGR2A',
'FCGR2B',
'TUBB2B',
'PIKFYVE',
'HLA-DQB1',
'HLA-DRA',
'PIK3C3',
'FCGR2C',
'CALR',
'TLR6',
'TLR4',
'RAB7A',
'RAB7B',
'RAB5C',
'CTSS',
'LOC102723407',
'FCGR3A',
'FCGR3B',
'CLEC7A',
'CTSL',
'SEC61G',
'SEC61B',
'CD36',
'HLA-DQA2',
'DYNC1I2',
'HLA-DQA1',
'DYNC1I1',
'ATP6V1G1',
'ATP6V0E1',
'ATP6V1G2',
'ATP6V1G3',
'ATP6V0E2',
'TUBB4B',
'TUBB4A',
'CANX',
'HLA-DPB1',
'SFTPA1',
'PLA2R1',
'SFTPA2',
'ATP6V0D2',
'SEC22B',
'DYNC1H1',
'ITGB2',
'ITGB1',
'COLEC12',
'C1R',
'COLEC11',
'ITGB5',
'ITGB3',
'TCIRG1',
'THBS1',
'ITGAM',
'THBS3',
'TUBA1A',
'FCAR',
'THBS2',
'THBS4',
'EEA1',
'SEC61A2',
'HLA-DMB',
'TUBA1C',
'FCGR1A',
'TUBA1B',
'SEC61A1',
'MRC1',
'MRC2',
'HLA-DPA1',
'RAC1',
'NOS1',
'ITGAV',
'HLA-DMA',
'MBL2',
'SCARB1',
'OLR1'],
'Tuberculosis Homo sapiens hsa05152': ['TGFB1',
'CD74',
'TGFB3',
'TGFB2',
'BAD',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'CLEC4E',
'MAPK10',
'IL23A',
'RFX5',
'CD209',
'BAX',
'CLEC4M',
'CALM2',
'CALM3',
'CALM1',
'RAF1',
'RELA',
'ATP6V0D1',
'CALML6',
'CALML3',
'TNF',
'NOD2',
'CALML5',
'LAMP2',
'LAMP1',
'AKT3',
'AKT1',
'AKT2',
'HLA-DOB',
'HLA-DOA',
'ARHGEF12',
'IFNA13',
'CREBBP',
'IFNA14',
'ATP6V0C',
'HLA-DRB5',
'ATP6V0B',
'IFNA16',
'IFNA17',
'ATP6AP1',
'PLK3',
'RFXANK',
'TIRAP',
'NFKB1',
'MYD88',
'CREB1',
'RFXAP',
'TRAF6',
'HLA-DRB4',
'RAB5A',
'HLA-DRB3',
'RAB5B',
'IFNA10',
'HLA-DRB1',
'BCL10',
'CORO1A',
'C3',
'PPP3R1',
'PPP3R2',
'CYP27B1',
'ATP6V0A4',
'IL12B',
'IL12A',
'CD14',
'IFNA21',
'ATP6V0A1',
'ATP6V1H',
'ATP6V0A2',
'HSPA9',
'RHOA',
'VDR',
'IL10',
'KSR1',
'APAF1',
'IL10RB',
'CARD9',
'SPHK2',
'IL10RA',
'SPHK1',
'IRAK4',
'IL18',
'TNFRSF1A',
'IL1A',
'TLR2',
'IL1B',
'TLR1',
'FCGR2A',
'FCGR2B',
'IL6',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'BCL2',
'TLR9',
'CYCS',
'PIK3C3',
'FCGR2C',
'TLR6',
'TLR4',
'RAB7A',
'RAB5C',
'TRADD',
'CTSS',
'LOC102723407',
'PPP3CA',
'FCGR3A',
'PPP3CB',
'FCGR3B',
'PPP3CC',
'CASP8',
'CASP9',
'CLEC7A',
'IRAK2',
'CASP10',
'IRAK1',
'LBP',
'CASP3',
'FADD',
'RIPK2',
'FCER1G',
'CIITA',
'HLA-DQA2',
'CTSD',
'HLA-DQA1',
'CAMP',
'CR1',
'NFYB',
'STAT1',
'IFNGR1',
'NFYC',
'SYK',
'IFNGR2',
'HLA-DPB1',
'PLA2R1',
'ATP6V0D2',
'ITGB2',
'IFNA6',
'CAMK2D',
'IFNA5',
'CEBPB',
'SRC',
'IFNA8',
'IFNA7',
'LSP1',
'IFNA2',
'IFNA1',
'CEBPG',
'CAMK2A',
'IFNA4',
'CAMK2B',
'TCIRG1',
'ITGAM',
'HSPD1',
'MALT1',
'EEA1',
'HLA-DMB',
'MAPK9',
'FCGR1A',
'MAPK8',
'EP300',
'MRC1',
'MRC2',
'HLA-DPA1',
'MAPK3',
'ITGAX',
'MAPK1',
'IFNB1',
'NOS2',
'NFYA',
'CAMK2G',
'HLA-DMA',
'BID',
'JAK1',
'JAK2'],
'Toxoplasmosis Homo sapiens hsa05145': ['TGFB1',
'TGFB3',
'TGFB2',
'BAD',
'HSPA1L',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'HSPA1A',
'PPIF',
'HSPA1B',
'RELA',
'TNF',
'AKT3',
'ALOX5',
'AKT1',
'AKT2',
'HLA-DOB',
'MAP3K7',
'LDLR',
'HLA-DOA',
'HLA-DRB5',
'MAP2K3',
'NFKB1',
'MYD88',
'PIK3R1',
'TRAF6',
'BCL2L1',
'BIRC7',
'BIRC8',
'TAB2',
'HLA-DRB4',
'TAB1',
'HLA-DRB3',
'BIRC2',
'BIRC3',
'HLA-DRB1',
'IL12B',
'IL12A',
'MAP2K6',
'IL10',
'LAMB4',
'HSPA6',
'LAMB3',
'IL10RB',
'HSPA8',
'IL10RA',
'HSPA2',
'LAMB2',
'IRAK4',
'LAMB1',
'TYK2',
'TNFRSF1A',
'TLR2',
'NFKBIB',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'IFNG',
'GNAO1',
'HLA-DQB1',
'HLA-DRA',
'BCL2',
'CYCS',
'ITGA6',
'TLR4',
'CD40',
'LAMC1',
'PIK3R5',
'LAMC3',
'PIK3R3',
'LY96',
'LAMC2',
'PIK3R2',
'SOCS1',
'CASP8',
'CASP9',
'IRAK1',
'CASP3',
'CIITA',
'CCR5',
'HLA-DQA2',
'HLA-DQA1',
'STAT1',
'IFNGR1',
'IFNGR2',
'CHUK',
'PDPK1',
'STAT3',
'IRGM',
'XIAP',
'HLA-DPB1',
'CD40LG',
'ITGB1',
'LAMA3',
'LAMA2',
'LAMA5',
'LAMA4',
'LAMA1',
'PIK3CD',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'IKBKB',
'HLA-DMB',
'MAPK9',
'MAPK8',
'HLA-DPA1',
'MAPK3',
'MAPK1',
'NOS2',
'IKBKG',
'HLA-DMA',
'JAK1',
'JAK2'],
'Leishmaniasis Homo sapiens hsa05140': ['TGFB1',
'TGFB3',
'IL10',
'TGFB2',
'JUN',
'ITGA4',
'IRAK4',
'MAPK13',
'MAPK14',
'IL1A',
'TLR2',
'MAPK11',
'NFKBIB',
'IL4',
'IL1B',
'NFKBIA',
'MAPK12',
'FCGR2A',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'NCF1',
'FCGR2C',
'PTPN6',
'TLR4',
'RELA',
'TNF',
'LOC102723407',
'FCGR3A',
'FCGR3B',
'IRAK1',
'HLA-DOB',
'MAP3K7',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'CR1',
'MARCKSL1',
'HLA-DRB5',
'STAT1',
'IFNGR1',
'IFNGR2',
'FOS',
'PRKCB',
'CYBA',
'NFKB1',
'MYD88',
'TRAF6',
'HLA-DPB1',
'TAB2',
'HLA-DRB4',
'TAB1',
'HLA-DRB3',
'HLA-DRB1',
'ITGB2',
'ITGB1',
'NCF2',
'NCF4',
'ITGAM',
'ELK1',
'C3',
'PTGS2',
'HLA-DMB',
'FCGR1A',
'HLA-DPA1',
'MAPK3',
'MAPK1',
'IL12B',
'NOS2',
'IL12A',
'HLA-DMA',
'JAK1',
'JAK2'],
'Inflammatory bowel disease (IBD) Homo sapiens hsa05321': ['TGFB1',
'TGFB3',
'IL4R',
'IL10',
'TGFB2',
'JUN',
'IL13',
'NFATC1',
'IL18',
'FOXP3',
'IL2',
'IL5',
'IL1A',
'TLR2',
'IL4',
'IL1B',
'IL6',
'IL23A',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'TLR5',
'TLR4',
'IL18R1',
'RELA',
'IL21R',
'TNF',
'NOD2',
'IL2RG',
'TBX21',
'STAT6',
'HLA-DOB',
'IL12RB2',
'IL12RB1',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'SMAD3',
'SMAD2',
'HLA-DRB5',
'STAT1',
'IFNGR1',
'IFNGR2',
'STAT3',
'STAT4',
'NFKB1',
'IL17A',
'MAF',
'HLA-DPB1',
'IL17F',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'IL22',
'IL21',
'IL23R',
'RORC',
'GATA3',
'RORA',
'HLA-DMB',
'IL18RAP',
'HLA-DPA1',
'IL12B',
'IL12A',
'HLA-DMA'],
'Asthma Homo sapiens hsa05310': ['HLA-DRB5',
'IL10',
'IL13',
'PRG2',
'RNASE3',
'IL3',
'IL5',
'IL4',
'IL9',
'HLA-DQB1',
'HLA-DRA',
'HLA-DPB1',
'HLA-DRB4',
'CD40LG',
'HLA-DRB3',
'MS4A2',
'HLA-DRB1',
'CD40',
'CCL11',
'TNF',
'EPX',
'LOC102723407',
'HLA-DMB',
'HLA-DPA1',
'FCER1A',
'HLA-DOB',
'FCER1G',
'HLA-DMA',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1'],
'Intestinal immune network for IgA production Homo sapiens hsa04672': ['TGFB1',
'CCL25',
'AICDA',
'IL15RA',
'HLA-DRB5',
'IL10',
'IL15',
'ITGA4',
'TNFSF13',
'IL2',
'IL5',
'IL4',
'CXCL12',
'IL6',
'LTBR',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'HLA-DPB1',
'HLA-DRB4',
'CD40LG',
'MAP3K14',
'HLA-DRB3',
'CCL28',
'HLA-DRB1',
'CD86',
'CD40',
'TNFRSF13C',
'TNFRSF13B',
'PIGR',
'CD80',
'TNFSF13B',
'LOC102723407',
'HLA-DMB',
'CXCR4',
'HLA-DPA1',
'TNFRSF17',
'MADCAM1',
'CCR9',
'ITGB7',
'HLA-DOB',
'HLA-DMA',
'HLA-DQA2',
'ICOSLG',
'ICOS',
'HLA-DOA',
'HLA-DQA1',
'CCR10'],
'Viral myocarditis Homo sapiens hsa05416': ['CAV1',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'CYCS',
'MYH6',
'MYH7',
'CD86',
'CD40',
'CD80',
'LOC102723407',
'ACTB',
'CASP8',
'CASP9',
'CCND1',
'DAG1',
'CASP3',
'HLA-DOB',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'CXADR',
'HLA-DRB5',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'EIF4G1',
'HLA-DPB1',
'HLA-DRB4',
'CD40LG',
'HLA-DRB3',
'EIF4G3',
'EIF4G2',
'HLA-DRB1',
'ITGB2',
'LAMA2',
'ACTG1',
'PRF1',
'ITGAL',
'ICAM1',
'SGCG',
'HLA-DMB',
'SGCD',
'SGCB',
'SGCA',
'HLA-DPA1',
'RAC3',
'ABL2',
'RAC1',
'FYN',
'DMD',
'RAC2',
'ABL1',
'HLA-DMA',
'BID',
'CD55'],
'Autoimmune thyroid disease Homo sapiens hsa05320': ['IL10',
'IL2',
'IL5',
'IL4',
'TG',
'FAS',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'CD86',
'CD40',
'CD80',
'LOC102723407',
'CTLA4',
'HLA-DOB',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'IFNA13',
'IFNA14',
'HLA-DRB5',
'IFNA16',
'IFNA17',
'GZMB',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'TSHR',
'HLA-DPB1',
'HLA-DRB4',
'CD40LG',
'HLA-DRB3',
'IFNA10',
'HLA-DRB1',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'PRF1',
'FASLG',
'HLA-DMB',
'TPO',
'HLA-DPA1',
'HLA-DMA',
'CGA',
'IFNA21',
'TSHB'],
'Allograft rejection Homo sapiens hsa05330': ['HLA-DRB5',
'IL10',
'GZMB',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'IL2',
'IL5',
'IL4',
'FAS',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'HLA-DPB1',
'HLA-DRB4',
'CD40LG',
'HLA-DRB3',
'HLA-DRB1',
'CD86',
'CD40',
'CD80',
'PRF1',
'TNF',
'FASLG',
'LOC102723407',
'HLA-DMB',
'HLA-DPA1',
'IL12B',
'IL12A',
'HLA-DOB',
'HLA-DMA',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1'],
'Type I diabetes mellitus Homo sapiens hsa04940': ['PTPRN2',
'HLA-DRB5',
'GZMB',
'GAD2',
'GAD1',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'IL2',
'IL1A',
'IL1B',
'FAS',
'CPE',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'LTA',
'CD28',
'HLA-DPB1',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'CD86',
'CD80',
'PRF1',
'PTPRN',
'TNF',
'FASLG',
'ICA1',
'HSPD1',
'INS',
'HLA-DMB',
'HLA-DPA1',
'IL12B',
'IL12A',
'HLA-DOB',
'HLA-DMA',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1'],
'Graft-versus-host disease Homo sapiens hsa05332': ['HLA-DRB5',
'GZMB',
'HLA-C',
'KIR3DL1',
'HLA-A',
'KIR3DL2',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'IL2',
'IL1A',
'IL1B',
'IL6',
'FAS',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'HLA-DPB1',
'KLRD1',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'CD86',
'CD80',
'PRF1',
'KIR2DL1',
'TNF',
'FASLG',
'KIR2DL2',
'KIR2DL3',
'HLA-DMB',
'HLA-DPA1',
'KLRC1',
'HLA-DOB',
'KIR2DL5A',
'HLA-DMA',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1'],
'Antigen processing and presentation Homo sapiens hsa04612': ['CTSB',
'CD74',
'HSP90AA1',
'KLRC3',
'HSPA6',
'KLRC4',
'HSPA5',
'HSPA1L',
'HSPA8',
'HSPA2',
'TAP2',
'HSPA4',
'TAP1',
'TAPBP',
'CD4',
'RFX5',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'HSPA1A',
'KLRD1',
'CALR',
'HSPA1B',
'KIR2DL1',
'TNF',
'KIR2DL2',
'KIR2DL3',
'KIR2DL4',
'CTSS',
'CTSL',
'HLA-DOB',
'B2M',
'KIR2DL5A',
'CIITA',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'PDIA3',
'HLA-DRB5',
'KIR2DS1',
'NFYB',
'KIR2DS2',
'NFYC',
'KIR2DS3',
'KIR2DS4',
'KIR2DS5',
'HLA-C',
'RFXANK',
'KIR3DL1',
'HLA-A',
'KIR3DL2',
'HLA-B',
'KIR3DL3',
'HLA-G',
'HLA-E',
'HLA-F',
'CREB1',
'CD8B',
'CD8A',
'RFXAP',
'PSME2',
'CANX',
'LGMN',
'HLA-DPB1',
'PSME3',
'PSME1',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'HSP90AB1',
'IFI30',
'HLA-DMB',
'HLA-DPA1',
'KLRC1',
'NFYA',
'KLRC2',
'HLA-DMA'],
'Cell adhesion molecules (CAMs) Homo sapiens hsa04514': ['CADM3',
'CADM1',
'VCAM1',
'L1CAM',
'CD2',
'CD4',
'CD6',
'CNTN2',
'PDCD1',
'PVRL3',
'PVRL2',
'CNTN1',
'PVRL1',
'CD86',
'VTCN1',
'CD80',
'PVR',
'CLDN3',
'CLDN2',
'CLDN1',
'CDH5',
'CDH4',
'CDH3',
'CDH2',
'CDH1',
'MPZ',
'JAM2',
'HLA-DOB',
'JAM3',
'HLA-DOA',
'NTNG2',
'HLA-DRB5',
'NTNG1',
'HLA-C',
'HLA-A',
'HLA-B',
'SELE',
'HLA-G',
'HLA-E',
'HLA-F',
'OCLN',
'MAG',
'SELP',
'CD8B',
'CD8A',
'SELL',
'SDC1',
'ESAM',
'SDC2',
'CDH15',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'CD276',
'CD274',
'ICAM3',
'F11R',
'ICAM1',
'ICAM2',
'ALCAM',
'LRRC4B',
'CD99',
'LRRC4C',
'ITGA4',
'PDCD1LG2',
'VCAN',
'CLDN11',
'PTPRF',
'PTPRC',
'CLDN10',
'SIGLEC1',
'CLDN16',
'CLDN15',
'CLDN14',
'HLA-DQB1',
'HLA-DRA',
'ITGA9',
'PECAM1',
'CLDN19',
'CD28',
'ITGA8',
'CLDN18',
'CLDN17',
'ITGA6',
'CD22',
'NLGN2',
'CNTNAP2',
'NLGN3',
'CNTNAP1',
'CD40',
'NLGN1',
'NCAM1',
'SDC3',
'NRXN2',
'NRXN1',
'SDC4',
'PTPRM',
'NRXN3',
'LRRC4',
'GLG1',
'SPN',
'MPZL1',
'MADCAM1',
'CTLA4',
'NCAM2',
'CD34',
'HLA-DQA2',
'ICOS',
'HLA-DQA1',
'NLGN4X',
'NEGR1',
'CLDN7',
'CLDN6',
'CLDN5',
'NFASC',
'CLDN4',
'CLDN9',
'CLDN8',
'HLA-DPB1',
'CD226',
'CD40LG',
'ITGB2',
'ITGB1',
'SELPLG',
'ITGAM',
'ITGAL',
'CLDN23',
'CLDN22',
'HLA-DMB',
'CLDN20',
'CLDN25',
'CLDN24',
'HLA-DPA1',
'ITGB8',
'NRCAM',
'ITGB7',
'ITGAV',
'NEO1',
'CD58',
'TIGIT',
'HLA-DMA',
'ICOSLG'],
'Staphylococcus aureus infection Homo sapiens hsa05150': ['IL10',
'KRT10',
'FCGR2A',
'FCGR2B',
'DSG1',
'HLA-DQB1',
'HLA-DRA',
'FCGR2C',
'MASP1',
'C3AR1',
'FPR2',
'FPR1',
'FPR3',
'C4A',
'LOC102723407',
'C4B',
'FCGR3A',
'FCGR3B',
'HLA-DOB',
'HLA-DQA2',
'HLA-DOA',
'HLA-DQA1',
'HLA-DRB5',
'FGG',
'SELP',
'HLA-DPB1',
'MASP2',
'HLA-DRB4',
'HLA-DRB3',
'CFB',
'HLA-DRB1',
'C1QC',
'ITGB2',
'CFD',
'C1QB',
'C1QA',
'C1R',
'SELPLG',
'C5AR1',
'CFI',
'CFH',
'C1S',
'PTAFR',
'PLG',
'ITGAM',
'FCAR',
'ITGAL',
'C2',
'ICAM1',
'C3',
'C5',
'HLA-DMB',
'FCGR1A',
'HLA-DPA1',
'HLA-DMA',
'MBL2'],
'Complement and coagulation cascades Homo sapiens hsa04610': ['F11',
'F10',
'SERPIND1',
'F12',
'KLKB1',
'SERPINA1',
'MASP1',
'SERPINE1',
'PROS1',
'C3AR1',
'C4BPA',
'CLU',
'C4BPB',
'C8A',
'TFPI',
'C8B',
'SERPINA5',
'C4A',
'KNG1',
'C8G',
'C4B',
'BDKRB1',
'BDKRB2',
'FGA',
'CR1',
'FGB',
'SERPINB2',
'CR2',
'FGG',
'F2R',
'VWF',
'SERPINF2',
'PLAUR',
'F2',
'F3',
'F5',
'PROC',
'F7',
'F8',
'F9',
'PROCR',
'SERPING1',
'F13B',
'F2RL2',
'MASP2',
'CD46',
'F2RL3',
'CFB',
'C1QC',
'ITGB2',
'CFD',
'C1QB',
'C1QA',
'C1R',
'CPB2',
'SERPINC1',
'C5AR1',
'CFI',
'CFH',
'C1S',
'F13A1',
'PLAU',
'PLG',
'PLAT',
'ITGAM',
'C2',
'VTN',
'C3',
'C5',
'THBD',
'C6',
'C7',
'C9',
'ITGAX',
'VSIG4',
'A2M',
'CD59',
'MBL2',
'CD55'],
'Pertussis Homo sapiens hsa05133': ['RHOA',
'IL10',
'JUN',
'ITGA5',
'IRAK4',
'TICAM2',
'TICAM1',
'MAPK13',
'MAPK14',
'IL1A',
'MAPK11',
'IRF1',
'IL1B',
'MAPK12',
'IL6',
'MAPK10',
'IL23A',
'IRF3',
'IRF8',
'CALM2',
'CALM3',
'TLR4',
'CALM1',
'CXCL8',
'RELA',
'CALML6',
'C4BPA',
'CALML3',
'NOD1',
'C4BPB',
'TNF',
'LY96',
'CALML5',
'C4A',
'CXCL6',
'CXCL5',
'C4B',
'PYCARD',
'CASP7',
'CFL2',
'IRAK1',
'CFL1',
'NLRP3',
'CASP3',
'CASP1',
'FOS',
'TIRAP',
'NFKB1',
'MYD88',
'TRAF6',
'SERPING1',
'SFTPA1',
'SFTPA2',
'C1QC',
'ITGB2',
'C1QB',
'ITGB1',
'C1QA',
'C1R',
'C1S',
'ITGAM',
'GNAI1',
'C2',
'GNAI2',
'C3',
'GNAI3',
'C5',
'MAPK9',
'MAPK8',
'MAPK3',
'MAPK1',
'IL12B',
'NOS2',
'IL12A',
'CD14'],
'Legionellosis Homo sapiens hsa05134': ['HSPA6',
'APAF1',
'HSPA1L',
'HSPA8',
'HSPA2',
'IL18',
'EEF1A2',
'TLR2',
'EEF1A1',
'IL1B',
'NFKBIA',
'CLK1',
'IL6',
'EEF1G',
'HSPA1A',
'CYCS',
'NAIP',
'TLR5',
'TLR4',
'HSPA1B',
'CXCL8',
'RAB1A',
'RELA',
'RAB1B',
'SAR1A',
'SAR1B',
'ARF1',
'HBS1L',
'CXCL2',
'TNF',
'NLRC4',
'CXCL1',
'CXCL3',
'BCL2L13',
'PYCARD',
'CASP8',
'CASP9',
'HSF1',
'CASP7',
'CASP3',
'CASP1',
'CR1',
'NFKB1',
'NFKB2',
'MYD88',
'SEC22B',
'ITGB2',
'VCP',
'ITGAM',
'HSPD1',
'C3',
'BNIP3',
'IL12B',
'IL12A',
'CD14'],
'Malaria Homo sapiens hsa05144': ['TGFB1',
'TGFB3',
'IL10',
'TGFB2',
'HBA1',
'HBA2',
'IL18',
'VCAM1',
'TLR2',
'IL1B',
'IL6',
'IFNG',
'PECAM1',
'TLR9',
'TLR4',
'CXCL8',
'GYPB',
'GYPA',
'CD40',
'CSF3',
'GYPC',
'LRP1',
'CD81',
'HBB',
'TNF',
'KLRC4-KLRK1',
'COMP',
'CD36',
'CR1',
'HGF',
'SELE',
'MYD88',
'SELP',
'ACKR1',
'SDC1',
'SDC2',
'MET',
'KLRB1',
'CD40LG',
'ITGB2',
'THBS1',
'THBS3',
'ITGAL',
'THBS2',
'ICAM1',
'THBS4',
'KLRK1',
'CCL2',
'IL12A'],
'African trypanosomiasis Homo sapiens hsa05143': ['PRKCG',
'IL10',
'HBA1',
'PRKCB',
'HBA2',
'PRKCA',
'IL18',
'SELE',
'VCAM1',
'IL1B',
'MYD88',
'PLCB4',
'IL6',
'FAS',
'APOA1',
'GNAQ',
'IFNG',
'F2RL1',
'TLR9',
'THOP1',
'PLCB2',
'PLCB3',
'IDO1',
'PLCB1',
'IDO2',
'HBB',
'LAMA4',
'HPR',
'TNF',
'FASLG',
'ICAM1',
'LOC102723407',
'IL12B',
'IL12A',
'APOL1'],
'Regulation of autophagy Homo sapiens hsa04140': ['ATG3',
'IFNA13',
'IFNA14',
'GABARAPL2',
'GABARAPL1',
'IFNA16',
'IFNA17',
'ATG10',
'ATG14',
'ATG13',
'ATG12',
'ATG16L2',
'ATG16L1',
'IFNG',
'ATG4D',
'ATG4C',
'ULK3',
'ATG4B',
'ULK2',
'ATG4A',
'ULK1',
'PIK3C3',
'IFNA10',
'IFNA6',
'BECN1',
'IFNA5',
'GABARAP',
'IFNA8',
'PRKAA2',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'PIK3R4',
'INS',
'PRKAA1',
'ATG7',
'IFNA21',
'ATG5'],
'Jak-STAT signaling pathway Homo sapiens hsa04630': ['PTPN2',
'IL4R',
'PRLR',
'OSM',
'LIFR',
'IL23A',
'LEP',
'IL6ST',
'STAM2',
'PTPN6',
'RAF1',
'CNTFR',
'CSF3R',
'EPO',
'CNTF',
'CSF3',
'CSF2',
'IL21R',
'MPL',
'IL2RG',
'IL27RA',
'IFNL1',
'IFNL3',
'CCND3',
'IFNL2',
'CCND2',
'CCND1',
'AKT3',
'MYC',
'AKT1',
'AKT2',
'STAT6',
'IL12RB2',
'IL12RB1',
'STAT5B',
'PIAS4',
'IFNA13',
'CREBBP',
'IFNA14',
'IFNA16',
'TSLP',
'CISH',
'IFNA17',
'STAM',
'GFAP',
'PIAS1',
'PIAS3',
'PIAS2',
'IFNW1',
'IL22RA2',
'IL22RA1',
'PIK3R1',
'BCL2L1',
'GRB2',
'IFNA10',
'IFNAR1',
'IL7R',
'IFNAR2',
'IL23R',
'CSH2',
'CSH1',
'IL20RB',
'IL5RA',
'CSF2RA',
'CSF2RB',
'IL20RA',
'PIM1',
'LEPR',
'IL12B',
'IL12A',
'IL6R',
'IL13RA1',
'IFNA21',
'IL13RA2',
'STAT5A',
'IL11',
'IL10',
'IL15',
'IL10RB',
'IL13',
'IL10RA',
'IL19',
'PTPN11',
'IFNLR1',
'LIF',
'TYK2',
'OSMR',
'GH1',
'IL3',
'IL2',
'IL5',
'IFNE',
'GH2',
'IL4',
'IL7',
'IL6',
'PIK3CB',
'IL9',
'PIK3CA',
'IL3RA',
'IFNG',
'BCL2',
'IL9R',
'IRF9',
'IFNK',
'SOS2',
'CRLF2',
'SOS1',
'PIK3R5',
'PRL',
'PIK3R3',
'PIK3R2',
'SOCS3',
'GHR',
'SOCS4',
'SOCS1',
'SOCS2',
'THPO',
'AOX1',
'SOCS7',
'MCL1',
'SOCS5',
'SOCS6',
'IL15RA',
'STAT1',
'IFNGR1',
'STAT2',
'IFNGR2',
'IL11RA',
'STAT3',
'STAT4',
'EPOR',
'MTOR',
'IL2RA',
'IL2RB',
'IL17D',
'IL22',
'IFNA6',
'IFNA5',
'IL20',
'IFNA8',
'IL21',
'IFNA7',
'CTF1',
'IFNA2',
'CDKN1A',
'IFNA1',
'IL24',
'FHL1',
'IFNA4',
'PIK3CD',
'PIK3CG',
'EP300',
'HRAS',
'IFNB1',
'JAK3',
'JAK1',
'JAK2'],
'Cytokine-cytokine receptor interaction Homo sapiens hsa04060': ['ACVR1',
'EGF',
'IL1R1',
'IL1R2',
'IL23A',
'TNFSF4',
'LEP',
'TNFSF9',
'TNFSF8',
'CNTFR',
'CNTF',
'IL21R',
'IL2RG',
'IFNL1',
'IFNL3',
'IFNL2',
'FLT3LG',
'KDR',
'NGFR',
'IL17RA',
'XCR1',
'TNFSF18',
'TNFSF15',
'TSLP',
'TNFSF13',
'TNFSF14',
'PPBP',
'GDF5',
'IL17RB',
'IL22RA2',
'IL22RA1',
'TNFRSF6B',
'IL23R',
'PDGFC',
'IL20RB',
'PDGFB',
'PDGFA',
'EDA2R',
'IL20RA',
'TNFSF11',
'TNFSF12',
'IL12B',
'TNFSF10',
'IL12A',
'CCR10',
'CCL26',
'CCR2',
'IL11',
'CCR1',
'CCL25',
'CCL24',
'IL10',
'CCL23',
'CCL22',
'IL15',
'TNFRSF12A',
'CCL21',
'CCL20',
'IL10RB',
'IL13',
'IL10RA',
'VEGFC',
'IL19',
'LIF',
'IL18',
'OSMR',
'VEGFA',
'VEGFB',
'IL1A',
'IL1B',
'KITLG',
'CLCF1',
'CD27',
'CCL28',
'CRLF2',
'CCL27',
'IL18R1',
'CD40',
'TNFRSF11A',
'PRL',
'TNFRSF11B',
'CX3CL1',
'CCR9',
'CCR8',
'CCR7',
'CCR6',
'CCR5',
'CCR4',
'PF4V1',
'CCR3',
'IFNGR1',
'IFNGR2',
'IL11RA',
'IL17A',
'KIT',
'PLEKHO2',
'CD40LG',
'IL17B',
'CCL15',
'IL22',
'IFNA6',
'CCL14',
'IFNA5',
'CCL13',
'IL20',
'IFNA8',
'IL21',
'IFNA7',
'IL26',
'CCL11',
'TNFRSF13C',
'CTF1',
'IFNA2',
'TNFRSF13B',
'IFNA1',
'IL24',
'IFNA4',
'IL25',
'CXCR6',
'CXCR5',
'CXCR2',
'CXCR1',
'CXCR4',
'CXCR3',
'IFNB1',
'CCL19',
'CCL18',
'CCL17',
'CCL16',
'TGFB1',
'PDGFRB',
'TGFB3',
'PDGFRA',
'IL4R',
'PRLR',
'TGFB2',
'CD70',
'OSM',
'LIFR',
'EDAR',
'CXCL10',
'CXCL11',
'CXCL12',
'CXCL13',
'FAS',
'IL6ST',
'PF4',
'FIGF',
'CSF3R',
'EPO',
'CSF3',
'CSF2',
'CSF1',
'MPL',
'IL1RAP',
'TNF',
'CXCL14',
'EGFR',
'CXCL16',
'RELT',
'IL12RB2',
'IL12RB1',
'IFNA13',
'IFNA14',
'IFNA16',
'IFNA17',
'HGF',
'INHBA',
'TNFRSF10D',
'TNFRSF10C',
'INHBC',
'TNFRSF10B',
'INHBB',
'TNFRSF10A',
'INHBE',
'IFNW1',
'IFNA10',
'IFNAR1',
'IL7R',
'IFNAR2',
'CSF1R',
'AMHR2',
'CCL4L1',
'CCL4L2',
'IL5RA',
'FASLG',
'CSF2RA',
'CSF2RB',
'IL18RAP',
'TNFRSF8',
'TNFRSF9',
'LEPR',
'TNFRSF4',
'IL6R',
'IL13RA1',
'IFNA21',
'TNFRSF19',
'XCL1',
'IFNLR1',
'TGFBR1',
'TGFBR2',
'ACVR2B',
'BMP7',
'GH1',
'IL3',
'TNFRSF1A',
'ACVR2A',
'IL2',
'TNFRSF1B',
'IL5',
'TNFRSF21',
'IFNE',
'GH2',
'IL4',
'IL7',
'BMP2',
'IL6',
'IL9',
'IL3RA',
'IFNG',
'XCL2',
'IL9R',
'IFNK',
'TNFRSF25',
'BMPR1A',
'BMPR1B',
'EDA',
'CXCL8',
'BMPR2',
'CXCL9',
'CCL3L1',
'CCL3L3',
'CXCL2',
'CXCL1',
'CXCL3',
'CXCL6',
'CXCL5',
'GHR',
'THPO',
'TNFRSF17',
'TNFRSF18',
'AMH',
'TNFRSF14',
'IL15RA',
'EPOR',
'LTBR',
'IL2RA',
'IL2RB',
'LTB',
'LTA',
'MET',
'ACKR3',
'FLT1',
'FLT3',
'FLT4',
'CX3CR1',
'ACVR1B',
'TNFSF13B',
'CCL8',
'CCL7',
'CCL5',
'CCL4',
'CCL3',
'CCL2',
'CCL1'],
'Hematopoietic cell lineage Homo sapiens hsa04640': ['ITGA1',
'IL11',
'IL4R',
'IL1R1',
'ITGA5',
'IL1R2',
'ITGA4',
'ITGA3',
'ITGA2',
'DNTT',
'GP5',
'GP9',
'IL3',
'IL5',
'IL1A',
'CD2',
'IL4',
'IL1B',
'CD5',
'IL7',
'CD4',
'KITLG',
'IL6',
'CD7',
'CD9',
'IL3RA',
'HLA-DRA',
'IL9R',
'ITGA6',
'CD24',
'MS4A1',
'FCER2',
'CD22',
'CSF3R',
'EPO',
'GYPA',
'CSF3',
'CSF2',
'CSF1',
'ITGA2B',
'TNF',
'CD3G',
'CD3E',
'CD3D',
'LOC102723407',
'THPO',
'FLT3LG',
'CD38',
'CD37',
'CD36',
'CD34',
'CD33',
'CR1',
'HLA-DRB5',
'CR2',
'MME',
'IL11RA',
'GP1BB',
'GP1BA',
'EPOR',
'KIT',
'CD8B',
'IL2RA',
'CD8A',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'CD44',
'IL7R',
'CSF1R',
'FLT3',
'TFRC',
'ITGB3',
'IL5RA',
'CD1E',
'ITGAM',
'CD1D',
'CSF2RA',
'CD1C',
'CD1B',
'CD1A',
'FCGR1A',
'ANPEP',
'CD19',
'CD59',
'IL6R',
'CD14',
'CD55'],
'Transcriptional misregulation in cancer Homo sapiens hsa05202': ['LMO2',
'IL1R2',
'ZBTB17',
'ZBTB16',
'DEFA3',
'RUNX1',
'GOLPH3L',
'RUNX2',
'PML',
'HIST3H3',
'WT1',
'MYCN',
'NUPR1',
'SPINT1',
'CDK14',
'TP53',
'CD86',
'RELA',
'ATF1',
'CSF2',
'PRCC',
'CCNT2',
'HPGD',
'CCNT1',
'EWSR1',
'MPO',
'FOXO1',
'HOXA11',
'HOXA10',
'RXRA',
'RXRB',
'HOXA9',
'CCND2',
'MYC',
'RXRG',
'RUNX1T1',
'ELANE',
'NGFR',
'SMAD1',
'IGFBP3',
'TRAF1',
'PBX3',
'ASPSCR1',
'IGF1',
'NFKB1',
'FLI1',
'PTK2',
'PBX1',
'NR4A3',
'MAF',
'CCNA1',
'TLX3',
'TLX1',
'COMMD3-BMI1',
'BCL2L1',
'ERG',
'BMP2K',
'TCF3',
'BIRC3',
'MDM2',
'CSF1R',
'GRIA3',
'SLC45A3',
'MAX',
'SPI1',
'DDX5',
'WHSC1',
'KMT2A',
'JMJD1C',
'PDGFA',
'PLAU',
'PLAT',
'IGF1R',
'ELK4',
'HIST1H3A',
'HIST1H3B',
'TSPAN7',
'HIST1H3G',
'HIST1H3H',
'HIST1H3I',
'HIST1H3J',
'CD14',
'HIST1H3C',
'PROM1',
'HIST1H3D',
'SSX1',
'MEN1',
'HIST1H3E',
'SSX2',
'HIST1H3F',
'SS18',
'DUSP6',
'FUS',
'H3F3C',
'JUP',
'MMP3',
'H3F3A',
'H3F3B',
'HMGA2',
'PAX5',
'NFKBIZ',
'ETV1',
'PAX7',
'MMP9',
'BAIAP3',
'ETV4',
'ETV5',
'MLF1',
'TGFBR2',
'IL3',
'PAX3',
'ETV6',
'WNT16',
'SUPT3H',
'ETV7',
'ZEB1',
'CDK9',
'NCOR1',
'SP1',
'IL6',
'MEIS1',
'PAX8',
'BCL6',
'ID2',
'FEV',
'REL',
'ATM',
'RARA',
'CXCL8',
'DOT1L',
'CD40',
'BCL2A1',
'TMPRSS2',
'MLLT1',
'MLLT3',
'BMI1',
'LOC102723407',
'AFF1',
'FUT8',
'UTY',
'TFE3',
'CCR7',
'KDM6A',
'ARNT2',
'CDKN2C',
'TAF15',
'NTRK1',
'EYA1',
'PTCRA',
'MEF2C',
'GZMB',
'KLF3',
'HIST2H3A',
'PER2',
'HIST2H3C',
'GOLPH3',
'IL2RB',
'PPARG',
'DDIT3',
'MET',
'HIST2H3D',
'SSX2B',
'CEBPA',
'CEBPB',
'FLT1',
'CDKN1B',
'HDAC1',
'CEBPE',
'FLT3',
'HDAC2',
'CDKN1A',
'LDB1',
'SIX1',
'ITGAM',
'LYL1',
'FCGR1A',
'HHEX',
'SIN3A',
'SIX4',
'ITGB7'],
'Alcoholism Homo sapiens hsa05034': ['HIST1H4L',
'GRIN2D',
'PDYN',
'GRIN2C',
'PPP1CA',
'GRIN1',
'PPP1CB',
'HIST3H3',
'GRIN3A',
'HIST1H4A',
'HIST1H4B',
'HIST1H4C',
'GRIN3B',
'HAT1',
'HIST1H4H',
'HIST1H4I',
'HIST1H4J',
'HIST1H4K',
'CALM2',
'HIST1H4D',
'CALM3',
'HIST1H4E',
'HIST1H4F',
'CALM1',
'RAF1',
'HIST1H4G',
'ATF2',
'CALML6',
'ATF6B',
'ADCY5',
'CALML3',
'CALML5',
'ARAF',
'PPP1CC',
'GNG2',
'CREB3L1',
'NRAS',
'GNG4',
'GNG3',
'CREB3L4',
'GNG5',
'CREB3L2',
'GNG8',
'CREB3L3',
'GNG7',
'HIST1H2AE',
'HIST1H2AH',
'HIST1H2AG',
'HIST1H2AB',
'HIST1H2AA',
'HIST1H2AD',
'HIST1H2AC',
'MAP2K1',
'HIST2H2BF',
'HIST2H2BE',
'CREB3',
'CREB1',
'GNB1',
'PPP1R1B',
'GNB3',
'PKIA',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'GRB2',
'H2AFY2',
'ATF4',
'CREB5',
'HDAC11',
'HDAC10',
'SLC6A3',
'H2BFM',
'HIST1H3A',
'GNG11',
'GRIN2B',
'HIST1H3B',
'GNG10',
'GRIN2A',
'HIST1H3G',
'HIST1H3H',
'HIST1H3I',
'HIST1H3J',
'HIST1H3C',
'HIST1H3D',
'HIST1H3E',
'PRKACA',
'HIST1H3F',
'H3F3C',
'BDNF',
'H3F3A',
'H3F3B',
'BRAF',
'GNG13',
'GNG12',
'HIST3H2A',
'TH',
'ADORA2B',
'H2BFWT',
'GNAO1',
'ADORA2A',
'CAMK4',
'SOS2',
'SOS1',
'HIST2H2AA4',
'H2AFB1',
'HIST2H2AA3',
'SHC3',
'H2AFB2',
'SHC4',
'H2AFB3',
'SHC1',
'SHC2',
'MAOB',
'MAOA',
'HIST2H2AC',
'HIST2H2AB',
'GNGT2',
'GNGT1',
'H2AFJ',
'DRD1',
'DRD2',
'SLC18A1',
'SLC18A2',
'NTRK2',
'HIST1H2AM',
'H2AFZ',
'HIST1H2AJ',
'HIST1H2AI',
'H2AFX',
'HIST1H2AL',
'H2AFY',
'HIST1H2AK',
'H2AFV',
'HIST2H3A',
'HIST2H3C',
'HIST1H2BA',
'HIST4H4',
'FOSB',
'HIST1H2BG',
'CRH',
'HIST1H2BF',
'HIST1H2BI',
'KRAS',
'HIST1H2BH',
'HIST1H2BC',
'SLC29A1',
'HIST2H3D',
'HIST1H2BB',
'HIST1H2BE',
'HIST1H2BD',
'HDAC5',
'HIST1H2BO',
'HDAC6',
'HIST1H2BN',
'HDAC3',
'HDAC4',
'DDC',
'HDAC1',
'HIST1H2BK',
'HDAC2',
'HIST1H2BJ',
'HIST1H2BM',
'HIST1H2BL',
'HDAC9',
'GNAI1',
'CAMKK1',
'GNAI2',
'CAMKK2',
'HDAC7',
'GNAI3',
'HDAC8',
'HIST2H4B',
'HIST2H4A',
'NPY',
'MAPK3',
'HRAS',
'MAPK1',
'HIST3H2BB'],
'Systemic lupus erythematosus Homo sapiens hsa05322': ['SSB',
'ACTN4',
'HIST1H4L',
'ACTN3',
'ACTN2',
'ACTN1',
'HIST3H3',
'HIST1H4A',
'HIST1H4B',
'HIST1H4C',
'HIST1H4H',
'HIST1H4I',
'HIST1H4J',
'HIST1H4K',
'HIST1H4D',
'HIST1H4E',
'HIST1H4F',
'SNRPB',
'HIST1H4G',
'CD86',
'CD80',
'TNF',
'C4A',
'C4B',
'SNRPD3',
'SNRPD1',
'HIST1H2AE',
'HIST1H2AH',
'HIST1H2AG',
'HLA-DOB',
'HIST1H2AB',
'HIST1H2AA',
'HIST1H2AD',
'HLA-DOA',
'ELANE',
'HIST1H2AC',
'HLA-DRB5',
'HIST2H2BF',
'HIST2H2BE',
'H2AFY2',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'C2',
'C3',
'H2BFM',
'C5',
'C6',
'HIST1H3A',
'GRIN2B',
'C7',
'HIST1H3B',
'GRIN2A',
'C9',
'HIST1H3G',
'HIST1H3H',
'HIST1H3I',
'HIST1H3J',
'HIST1H3C',
'HIST1H3D',
'HIST1H3E',
'HIST1H3F',
'IL10',
'H3F3C',
'H3F3A',
'H3F3B',
'HIST3H2A',
'FCGR2A',
'H2BFWT',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'CD28',
'HIST2H2AA4',
'H2AFB1',
'HIST2H2AA3',
'H2AFB2',
'CD40',
'H2AFB3',
'HIST2H2AC',
'HIST2H2AB',
'C8A',
'C8B',
'TROVE2',
'C8G',
'LOC102723407',
'FCGR3A',
'FCGR3B',
'H2AFJ',
'CTSG',
'HLA-DQA2',
'HLA-DQA1',
'HIST1H2AM',
'H2AFZ',
'HIST1H2AJ',
'HIST1H2AI',
'H2AFX',
'HIST1H2AL',
'H2AFY',
'HIST1H2AK',
'H2AFV',
'HIST2H3A',
'HIST2H3C',
'HIST1H2BA',
'HIST4H4',
'HIST1H2BG',
'HLA-DPB1',
'HIST1H2BF',
'HIST1H2BI',
'HIST1H2BH',
'CD40LG',
'HIST1H2BC',
'HIST2H3D',
'HIST1H2BB',
'HIST1H2BE',
'HIST1H2BD',
'C1QC',
'HIST1H2BO',
'C1QB',
'HIST1H2BN',
'C1QA',
'C1R',
'HIST1H2BK',
'C1S',
'HIST1H2BJ',
'HIST1H2BM',
'HIST1H2BL',
'HIST2H4B',
'HIST2H4A',
'HLA-DMB',
'FCGR1A',
'HLA-DPA1',
'HIST3H2BB',
'TRIM21',
'HLA-DMA'],
'Prion diseases Homo sapiens hsa05020': ['EGR1',
'MAP2K2',
'MAP2K1',
'HSPA5',
'PRNP',
'SOD1',
'IL1A',
'IL1B',
'IL6',
'HSPA1A',
'BAX',
'C1QC',
'C1QB',
'C1QA',
'NOTCH1',
'NCAM1',
'LAMC1',
'C8A',
'ELK1',
'C8B',
'C8G',
'STIP1',
'C5',
'PRKACG',
'C6',
'C7',
'CASP12',
'C9',
'CCL5',
'MAPK3',
'NCAM2',
'MAPK1',
'FYN',
'PRKACB',
'PRKACA'],
'Inositol phosphate metabolism Homo sapiens hsa00562': ['MIOX',
'TPI1',
'PLCH1',
'ITPK1',
'IPMK',
'OCRL',
'ITPKC',
'ALDH6A1',
'PIK3CB',
'PIK3CA',
'IMPAD1',
'PIKFYVE',
'ITPKA',
'ITPKB',
'PI4KB',
'PI4KA',
'PLCD1',
'PLCH2',
'PIK3C3',
'PLCD4',
'PI4K2B',
'PI4K2A',
'PLCD3',
'MTMR1',
'MTMR2',
'INPP1',
'MTMR3',
'MTMR4',
'IPPK',
'INPPL1',
'MTMR6',
'MTMR7',
'MTM1',
'MTMR8',
'PIP5KL1',
'PLCZ1',
'PLCE1',
'PIP4K2A',
'PIP4K2B',
'PIP4K2C',
'MINPP1',
'INPP4B',
'PLCB4',
'INPP4A',
'SYNJ2',
'SYNJ1',
'PLCB2',
'PLCB3',
'PLCB1',
'ISYNA1',
'MTMR14',
'PTEN',
'PIK3CD',
'PIK3C2G',
'PIK3C2B',
'PIK3C2A',
'PIK3CG',
'INPP5D',
'INPP5A',
'IMPA1',
'INPP5B',
'IMPA2',
'INPP5E',
'INPP5K',
'PIP5K1A',
'PIP5K1B',
'PLCG1',
'PIP5K1C',
'PLCG2',
'CDIPT',
'INPP5J'],
'Phosphatidylinositol signaling system Homo sapiens hsa04070': ['IPMK',
'OCRL',
'PLCD1',
'CALM2',
'PLCD4',
'CALM3',
'PI4K2B',
'CALM1',
'PI4K2A',
'PLCD3',
'DGKH',
'MTMR1',
'DGKG',
'MTMR2',
'INPP1',
'MTMR3',
'DGKE',
'MTMR4',
'CALML6',
'DGKD',
'DGKB',
'DGKA',
'CALML3',
'CALML5',
'INPPL1',
'MTMR6',
'MTMR7',
'MTMR8',
'PLCE1',
'PIP4K2A',
'PIP4K2B',
'PIP4K2C',
'PRKCG',
'PRKCB',
'PRKCA',
'DGKZ',
'INPP4B',
'INPP4A',
'PIK3R1',
'SYNJ2',
'SYNJ1',
'DGKQ',
'DGKK',
'DGKI',
'CDS2',
'CDS1',
'INPP5D',
'INPP5A',
'INPP5B',
'PPIP5K1',
'PPIP5K2',
'INPP5E',
'INPP5K',
'PIP5K1A',
'PIP5K1B',
'PLCG1',
'PIP5K1C',
'PLCG2',
'INPP5J',
'ITPK1',
'ITPKC',
'PIK3CB',
'PIK3CA',
'IMPAD1',
'PIKFYVE',
'ITPKA',
'ITPKB',
'PI4KB',
'PI4KA',
'PIK3C3',
'TMEM55B',
'IPPK',
'ITPR2',
'PIK3R5',
'ITPR3',
'PIK3R3',
'PIK3R2',
'MTM1',
'ITPR1',
'PLCZ1',
'IP6K2',
'IP6K1',
'IP6K3',
'PLCB4',
'PLCB2',
'PLCB3',
'PLCB1',
'TMEM55A',
'MTMR14',
'PTEN',
'PIK3CD',
'PIK3C2G',
'PIK3C2B',
'PIK3C2A',
'PIK3CG',
'IMPA1',
'IMPA2',
'CDIPT'],
'Calcium signaling pathway Homo sapiens hsa04020': ['TRHR',
'PDGFRB',
'PDGFRA',
'GRIN2D',
'GRIN2C',
'GRIN1',
'HTR5A',
'STIM1',
'STIM2',
'LTB4R2',
'ORAI3',
'SLC25A31',
'ORAI2',
'AGTR1',
'PLCD1',
'PPIF',
'ORAI1',
'CALM2',
'PLCD4',
'CALM3',
'CALM1',
'PLCD3',
'CHRM3',
'CHRM1',
'CHRM2',
'ADCY1',
'CALML6',
'CHRM5',
'CHRNA7',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'EGFR',
'ADCY7',
'CYSLTR2',
'CYSLTR1',
'PLCE1',
'NTSR1',
'PRKCG',
'F2R',
'TNNC1',
'TNNC2',
'PRKCB',
'PHKA2',
'AVPR1A',
'PRKCA',
'PHKA1',
'PHKB',
'AVPR1B',
'GNAL',
'CCKBR',
'GNAQ',
'GNAS',
'PTGFR',
'OXTR',
'PDE1C',
'CACNA1A',
'PDE1B',
'PDE1A',
'CACNA1C',
'CACNA1B',
'CACNA1E',
'CACNA1D',
'CACNA1G',
'CACNA1F',
'GRPR',
'HTR6',
'MYLK',
'CACNA1I',
'CACNA1H',
'HTR4',
'PRKACG',
'PPP3R1',
'PPP3R2',
'HTR7',
'GRIN2A',
'CACNA1S',
'PLCG1',
'PLCG2',
'PRKACB',
'PRKACA',
'SPHK2',
'SPHK1',
'TACR3',
'TACR1',
'TACR2',
'ITPKC',
'ADORA2B',
'ITPKA',
'ADORA2A',
'ITPKB',
'CAMK4',
'SLC25A4',
'ITPR2',
'HTR2C',
'ITPR3',
'ADRB1',
'ADRB2',
'HTR2A',
'ADRA1D',
'ADRB3',
'HTR2B',
'ADRA1B',
'ADRA1A',
'ITPR1',
'LOC102723407',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'HRH2',
'HRH1',
'ERBB4',
'TBXA2R',
'CCKAR',
'ERBB2',
'BDKRB1',
'ERBB3',
'PLCZ1',
'BDKRB2',
'DRD1',
'CD38',
'DRD5',
'LHCGR',
'NOS3',
'ATP2B4',
'ATP2B3',
'ATP2B2',
'ATP2B1',
'P2RX7',
'PLCB4',
'P2RX6',
'P2RX5',
'P2RX4',
'P2RX3',
'P2RX2',
'P2RX1',
'VDAC3',
'VDAC2',
'VDAC1',
'PLCB2',
'SLC25A6',
'PLCB3',
'SLC25A5',
'PLCB1',
'MYLK2',
'RYR2',
'MYLK3',
'CAMK2D',
'RYR3',
'RYR1',
'PTGER1',
'CAMK2A',
'PTAFR',
'PTGER3',
'CAMK2B',
'ATP2A3',
'ATP2A2',
'ATP2A1',
'SLC8A1',
'MYLK4',
'SLC8A2',
'GRM1',
'SLC8A3',
'GNA14',
'PLN',
'GNA15',
'EDNRA',
'EDNRB',
'GRM5',
'PHKG2',
'GNA11',
'PHKG1',
'PTK2B',
'NOS1',
'NOS2',
'CAMK2G'],
'Renin secretion Homo sapiens hsa04924': ['CTSB',
'GUCY1A3',
'GUCY1A2',
'ACE',
'AGT',
'PDE3B',
'AGTR1',
'PDE3A',
'ORAI1',
'REN',
'CALM2',
'CALM3',
'CALM1',
'NPR1',
'CALML6',
'ADCY5',
'ITPR2',
'ITPR3',
'CALML3',
'ADRB1',
'ADRB2',
'CALML5',
'ADRB3',
'AQP1',
'ADCY6',
'ITPR1',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'ADORA1',
'PRKG2',
'ADCYAP1',
'PLCB4',
'CREB1',
'KCNMA1',
'GNAQ',
'GNAS',
'PLCB2',
'PLCB3',
'PLCB1',
'GUCY1B3',
'PTGER2',
'PDE1C',
'PDE1B',
'PTGER4',
'PDE1A',
'CACNA1C',
'CACNA1D',
'GNAI1',
'CACNA1F',
'ADCYAP1R1',
'GNAI2',
'GNAI3',
'PRKACG',
'PPP3R1',
'EDNRA',
'PPP3R2',
'CACNA1S',
'CLCA2',
'CLCA1',
'PRKACB',
'KCNJ2',
'PRKACA',
'CLCA4'],
'Gap junction Homo sapiens hsa04540': ['GUCY1A3',
'PDGFRB',
'GUCY1A2',
'EGF',
'PDGFRA',
'MAP3K2',
'TUBB',
'TUBB2A',
'TUBA4A',
'TUBA8',
'GJD2',
'TUBB2B',
'CDK1',
'SOS2',
'SOS1',
'RAF1',
'ADCY1',
'TUBAL3',
'ADCY5',
'ITPR2',
'HTR2C',
'TUBB1',
'ADCY4',
'ITPR3',
'ADRB1',
'ADCY3',
'HTR2A',
'ADCY2',
'HTR2B',
'ADCY9',
'TUBA3C',
'ADCY8',
'EGFR',
'ADCY7',
'ADCY6',
'ITPR1',
'NRAS',
'TUBB8',
'TUBA3E',
'TUBA3D',
'TUBB6',
'CSNK1D',
'TUBB3',
'DRD1',
'DRD2',
'PRKG2',
'PRKG1',
'PRKCG',
'MAP2K5',
'MAP2K2',
'MAP2K1',
'PRKCB',
'PRKCA',
'TUBB4B',
'TUBB4A',
'TJP1',
'PLCB4',
'GNAQ',
'GNAS',
'GRB2',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'GUCY1B3',
'SRC',
'PDGFC',
'PDGFB',
'PDGFA',
'TUBA1A',
'GNAI1',
'GNAI2',
'GNAI3',
'LPAR1',
'GRM1',
'PRKACG',
'TUBA1C',
'GRM5',
'TUBA1B',
'GJA1',
'GNA11',
'PDGFD',
'MAPK3',
'HRAS',
'MAPK1',
'PRKACB',
'MAPK7',
'PRKACA'],
'Long-term depression Homo sapiens hsa04730': ['LYN',
'GUCY1A3',
'GUCY1A2',
'PPP2R1A',
'BRAF',
'GNAO1',
'RAF1',
'ITPR2',
'ITPR3',
'ARAF',
'ITPR1',
'NRAS',
'PRKG2',
'PRKG1',
'PRKCG',
'MAP2K2',
'PLA2G4E',
'MAP2K1',
'GRID2',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'IGF1',
'PRKCA',
'PPP2CA',
'PLCB4',
'GNAQ',
'JMJD7-PLA2G4B',
'GNAS',
'CRH',
'KRAS',
'PLCB2',
'PLCB3',
'GNAZ',
'PLCB1',
'GRIA2',
'CRHR1',
'GRIA3',
'GUCY1B3',
'PPP1R17',
'RYR1',
'GRIA1',
'CACNA1A',
'GNAI1',
'GNAI2',
'IGF1R',
'GNAI3',
'GRM1',
'PPP2CB',
'PPP2R1B',
'GNA11',
'GNA12',
'GNA13',
'MAPK3',
'HRAS',
'MAPK1',
'NOS1'],
'Long-term potentiation Homo sapiens hsa04720': ['BRAF',
'GRIN2D',
'GRIN2C',
'PPP1CA',
'GRIN1',
'PPP1CB',
'CAMK4',
'RAPGEF3',
'CALM2',
'CALM3',
'CALM1',
'RAF1',
'ADCY1',
'CALML6',
'ITPR2',
'ITPR3',
'CALML3',
'CALML5',
'ARAF',
'ADCY8',
'ITPR1',
'PPP1CC',
'PPP3CA',
'NRAS',
'PPP3CB',
'RAP1A',
'PPP3CC',
'RAP1B',
'PRKCG',
'CREBBP',
'MAP2K2',
'MAP2K1',
'PRKCB',
'PRKCA',
'PLCB4',
'PPP1R1A',
'GNAQ',
'KRAS',
'PLCB2',
'PLCB3',
'ATF4',
'PLCB1',
'GRIA2',
'CAMK2D',
'GRIA1',
'CAMK2A',
'CAMK2B',
'CACNA1C',
'GRM1',
'PRKACG',
'PPP3R1',
'PPP3R2',
'GRIN2B',
'RPS6KA6',
'GRM5',
'GRIN2A',
'RPS6KA1',
'RPS6KA3',
'EP300',
'RPS6KA2',
'MAPK3',
'HRAS',
'MAPK1',
'PRKACB',
'CAMK2G',
'PRKACA'],
'GnRH signaling pathway Homo sapiens hsa04912': ['MAP3K3',
'MAP3K4',
'MAP3K1',
'MAP3K2',
'JUN',
'MMP2',
'FSHB',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'MMP14',
'GNRH2',
'CALM2',
'SOS2',
'CALM3',
'GNRH1',
'CALM1',
'SOS1',
'RAF1',
'ADCY1',
'CALML6',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'PLD2',
'ADCY8',
'EGFR',
'PLD1',
'ADCY7',
'ADCY6',
'ITPR1',
'NRAS',
'GNRHR',
'MAP2K4',
'MAP2K2',
'MAP2K3',
'PRKCD',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'CDC42',
'PLCB4',
'GNAQ',
'JMJD7-PLA2G4B',
'GNAS',
'GRB2',
'KRAS',
'PLCB2',
'HBEGF',
'PLCB3',
'ATF4',
'PLCB1',
'CAMK2D',
'SRC',
'LHB',
'CAMK2A',
'CAMK2B',
'CACNA1C',
'CACNA1D',
'ELK1',
'CACNA1F',
'PRKACG',
'MAPK9',
'MAPK8',
'GNA11',
'CACNA1S',
'PTK2B',
'MAPK3',
'HRAS',
'MAPK1',
'PRKACB',
'CAMK2G',
'MAPK7',
'CGA',
'MAP2K6',
'PRKACA',
'MAP2K7'],
'Inflammatory mediator regulation of TRP channels Homo sapiens hsa04750': ['IL1R1',
'TRPV3',
'TRPV4',
'TRPV1',
'TRPV2',
'PPP1CA',
'MAPK13',
'PPP1CB',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'CALM2',
'CALM3',
'CALM1',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'IL1RAP',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'PPP1CC',
'PRKCH',
'PRKCG',
'MAP2K3',
'PRKCD',
'PLA2G4E',
'PLA2G4F',
'PLA2G4C',
'PRKCE',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'IGF1',
'PRKCA',
'PIK3R1',
'GNAQ',
'GNAS',
'PRKCQ',
'PLA2G6',
'PRKACG',
'PLCG1',
'TRPM8',
'PLCG2',
'PRKACB',
'MAP2K6',
'PRKACA',
'CYP2J2',
'TRPA1',
'IL1B',
'PIK3CB',
'PIK3CA',
'ITPR2',
'PIK3R5',
'HTR2C',
'ITPR3',
'PIK3R3',
'HTR2A',
'PIK3R2',
'HTR2B',
'ALOX12',
'ITPR1',
'ASIC5',
'HRH1',
'BDKRB1',
'P2RY2',
'BDKRB2',
'ASIC3',
'ASIC4',
'ASIC1',
'ASIC2',
'NTRK1',
'NGF',
'PLCB4',
'JMJD7-PLA2G4B',
'F2RL1',
'PLCB2',
'PLCB3',
'PLCB1',
'CAMK2D',
'SRC',
'PTGER2',
'CAMK2A',
'CAMK2B',
'PTGER4',
'PIK3CD',
'PIK3CG',
'MAPK9',
'MAPK8',
'CAMK2G'],
'Oxytocin signaling pathway Homo sapiens hsa04921': ['GUCY1A3',
'GUCY1A2',
'CACNA2D2',
'CACNA2D1',
'CACNA2D4',
'CACNA2D3',
'PRKAB1',
'PRKAB2',
'PPP1CA',
'PPP1CB',
'MYL6',
'CALM2',
'MYL9',
'CALM3',
'CALM1',
'RAF1',
'PRKAA2',
'ROCK1',
'ROCK2',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'EGFR',
'PRKAA1',
'ADCY7',
'ADCY6',
'PPP1CC',
'ACTB',
'NRAS',
'CCND1',
'PRKCG',
'MAP2K5',
'MAP2K2',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'EEF2',
'CACNB2',
'RCAN1',
'CACNB3',
'CACNB4',
'PIK3R1',
'GNAQ',
'GNAS',
'CACNB1',
'GUCY1B3',
'OXTR',
'CACNA1C',
'ACTG1',
'CACNA1D',
'ELK1',
'MYL6B',
'CACNA1F',
'MYLK',
'TRPM2',
'PRKACG',
'PPP3R1',
'PPP3R2',
'EEF2K',
'RGS2',
'CACNA1S',
'PRKACB',
'PRKACA',
'KCNJ5',
'RHOA',
'KCNJ6',
'PPP1R12A',
'PPP1R12B',
'JUN',
'KCNJ12',
'KCNJ9',
'KCNJ14',
'NFATC4',
'NFATC3',
'NFATC2',
'NFATC1',
'PIK3CB',
'PIK3CA',
'GNAO1',
'LOC101930123',
'CAMK4',
'CAMK1',
'PPP1R12C',
'NPR1',
'NPR2',
'ITPR2',
'PIK3R5',
'ITPR3',
'PIK3R3',
'PIK3R2',
'OXT',
'ITPR1',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'CD38',
'CAMK1D',
'MEF2C',
'NOS3',
'FOS',
'PLCB4',
'JMJD7-PLA2G4B',
'KRAS',
'PLCB2',
'PLCB3',
'CAMK1G',
'PLCB1',
'MYLK2',
'RYR2',
'MYLK3',
'CAMK2D',
'RYR3',
'SRC',
'RYR1',
'CDKN1A',
'CAMK2A',
'CAMK2B',
'PRKAG2',
'PRKAG3',
'PIK3CD',
'PRKAG1',
'GNAI1',
'CAMKK1',
'MYLK4',
'GNAI2',
'CAMKK2',
'PTGS2',
'GNAI3',
'PIK3CG',
'CACNG7',
'CACNG8',
'MAPK3',
'CACNG1',
'HRAS',
'MAPK1',
'CACNG2',
'CAMK2G',
'CACNG3',
'MAPK7',
'KCNJ2',
'CACNG4',
'CACNG5',
'KCNJ3',
'KCNJ4',
'CACNG6'],
'Vascular smooth muscle contraction Homo sapiens hsa04270': ['GUCY1A3',
'GUCY1A2',
'PPP1CA',
'PPP1CB',
'MYL6',
'AGTR1',
'CALM2',
'MYL9',
'CALM3',
'CALM1',
'RAF1',
'RAMP3',
'ROCK1',
'ROCK2',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ARAF',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'PPP1CC',
'MYH11',
'PRKCH',
'ARHGEF12',
'ARHGEF11',
'PRKCG',
'MAP2K2',
'PRKCD',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PRKCE',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'AVPR1A',
'PRKCA',
'AVPR1B',
'KCNU1',
'KCNMA1',
'GNAQ',
'GNAS',
'PRKCQ',
'MRVI1',
'GUCY1B3',
'CALCRL',
'CACNA1C',
'PLA2G3',
'PLA2G5',
'CACNA1D',
'PLA2G6',
'MYL6B',
'CACNA1F',
'MYLK',
'ACTG2',
'PRKACG',
'CALD1',
'KCNMB1',
'KCNMB2',
'KCNMB3',
'KCNMB4',
'CACNA1S',
'PRKACB',
'PRKACA',
'RHOA',
'PPP1R12A',
'PLA2G2E',
'PPP1R12B',
'PLA2G2F',
'PLA2G2C',
'PLA2G2D',
'CYP4A11',
'PLA2G2A',
'BRAF',
'ACTA2',
'ADORA2B',
'ADORA2A',
'PPP1R12C',
'NPR1',
'ARHGEF1',
'NPR2',
'ITPR2',
'ITPR3',
'ADRA1D',
'ADRA1B',
'ADRA1A',
'ITPR1',
'PRKG1',
'PPP1R14A',
'PLA2G12A',
'PLA2G12B',
'PTGIR',
'PLCB4',
'PLA2G10',
'JMJD7-PLA2G4B',
'RAMP1',
'PLCB2',
'RAMP2',
'PLCB3',
'PLCB1',
'MYLK2',
'MYLK3',
'PLA2G1B',
'CYP4A22',
'MYLK4',
'EDNRA',
'GNA11',
'GNA12',
'GNA13',
'MAPK3',
'MAPK1'],
'cGMP-PKG signaling pathway Homo sapiens hsa04022': ['GUCY1A3',
'GUCY1A2',
'BAD',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'PPP1CA',
'PPP1CB',
'SLC25A31',
'AGTR1',
'PPIF',
'GTF2IRD1',
'CALM2',
'MYL9',
'CALM3',
'CALM1',
'RAF1',
'ATF2',
'GTF2I',
'ROCK1',
'ROCK2',
'ADCY1',
'CALML6',
'ATF6B',
'ADCY5',
'ADCY4',
'CALML3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'CALML5',
'ATP1A2',
'MEF2BNB-MEF2B',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'ADCY6',
'PPP1CC',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'ADORA3',
'ADORA1',
'INSR',
'TRPC6',
'MAP2K2',
'MAP2K1',
'PRKCE',
'ADRA2C',
'ADRA2B',
'VASP',
'ADRA2A',
'CREB3',
'KCNU1',
'CREB1',
'PIK3R1',
'KCNMA1',
'GNAQ',
'MRVI1',
'ATF4',
'CREB5',
'CNGB1',
'GUCY1B3',
'IRS1',
'IRS2',
'CACNA1C',
'CACNA1D',
'IRS4',
'GATA4',
'CACNA1F',
'MYLK',
'PPP3R1',
'PPP3R2',
'KCNMB1',
'RGS2',
'KCNMB2',
'NPPB',
'KCNMB3',
'KCNMB4',
'CACNA1S',
'PDE2A',
'RHOA',
'PPP1R12A',
'KCNJ8',
'NFATC4',
'NFATC3',
'NFATC2',
'NFATC1',
'PIK3CB',
'PIK3CA',
'FXYD2',
'PDE3B',
'PDE3A',
'MYH7',
'SLC25A4',
'OPRD1',
'NPR1',
'NPR2',
'ITPR2',
'PIK3R5',
'ITPR3',
'ADRB1',
'ADRB2',
'PIK3R3',
'ADRA1D',
'ADRB3',
'PIK3R2',
'ADRA1B',
'ADRA1A',
'ITPR1',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'BDKRB2',
'PRKG2',
'PRKG1',
'CNGA1',
'MEF2B',
'MEF2A',
'MEF2D',
'MEF2C',
'NOS3',
'ATP2B4',
'ATP2B3',
'ATP2B2',
'ATP2B1',
'PLCB4',
'VDAC3',
'VDAC2',
'PDE5A',
'VDAC1',
'PLCB2',
'SLC25A6',
'PLCB3',
'SLC25A5',
'PLCB1',
'MYLK2',
'MYLK3',
'SRF',
'ATP2A3',
'ATP2A2',
'PIK3CD',
'ATP2A1',
'INS',
'GNAI1',
'SLC8A1',
'MYLK4',
'GNAI2',
'SLC8A2',
'GNAI3',
'PIK3CG',
'SLC8A3',
'PLN',
'EDNRA',
'EDNRB',
'GNA11',
'GNA12',
'GNA13',
'MAPK3',
'MAPK1'],
'Adrenergic signaling in cardiomyocytes Homo sapiens hsa04261': ['TPM4',
'TPM3',
'CACNA2D2',
'TPM2',
'CACNA2D1',
'CACNA2D4',
'CACNA2D3',
'PPP2R1A',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'PPP1CA',
'MAPK13',
'PPP1CB',
'MAPK14',
'MAPK11',
'MAPK12',
'MYL2',
'MYL3',
'MYL4',
'AGTR2',
'AGTR1',
'CALM2',
'CALM3',
'CALM1',
'ATF2',
'ADCY1',
'CALML6',
'ATF6B',
'ADCY5',
'ADCY4',
'CALML3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'CALML5',
'ATP1A2',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'SLC9A1',
'ADCY6',
'PPP1CC',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'SCN7A',
'AKT3',
'CREB3L3',
'TPM1',
'AKT1',
'AKT2',
'TNNC1',
'PRKCA',
'CREB3',
'CACNB2',
'CACNB3',
'CREB1',
'CACNB4',
'PIK3R1',
'TNNT2',
'PPP1R1A',
'GNAQ',
'GNAS',
'ATF4',
'CREB5',
'CACNB1',
'KCNE1',
'CACNA1C',
'CREM',
'CACNA1D',
'CACNA1F',
'PRKACG',
'CACNA1S',
'PRKACB',
'PRKACA',
'SCN1B',
'PPP2R5C',
'PPP2R5B',
'PPP2R5E',
'PPP2R5D',
'PPP2R5A',
'PIK3CB',
'PIK3CA',
'FXYD2',
'RAPGEF3',
'BCL2',
'SCN4B',
'MYH6',
'MYH7',
'RAPGEF4',
'PIK3R5',
'ADRB1',
'ADRB2',
'PIK3R3',
'ADRA1D',
'PIK3R2',
'ADRA1B',
'ADRA1A',
'PPP2R3A',
'ATP2B4',
'PPP2R3C',
'ATP2B3',
'PPP2R3B',
'ATP2B2',
'ATP2B1',
'PPP2CA',
'PLCB4',
'PPP2R2D',
'PPP2R2C',
'KCNQ1',
'PLCB2',
'PLCB3',
'PLCB1',
'RYR2',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'PPP2R2B',
'ATP2A2',
'PIK3CD',
'PPP2R2A',
'ACTC1',
'GNAI1',
'SLC8A1',
'GNAI2',
'GNAI3',
'PIK3CG',
'PPP2CB',
'RPS6KA5',
'PLN',
'CACNG7',
'CACNG8',
'PPP2R1B',
'SCN5A',
'MAPK3',
'TNNI3',
'CACNG1',
'MAPK1',
'CACNG2',
'CAMK2G',
'CACNG3',
'CACNG4',
'CACNG5',
'CACNG6'],
'cAMP signaling pathway Homo sapiens hsa04024': ['BAD',
'GRIN2D',
'GRIN2C',
'GRIN3A',
'MAPK10',
'GRIN3B',
'ORAI1',
'CALM2',
'MYL9',
'CALM3',
'CALM1',
'HCN4',
'VIPR2',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'PLCE1',
'AKT2',
'CREBBP',
'PIK3R1',
'PPP1R1B',
'CFTR',
'OXTR',
'HHIP',
'ADCYAP1R1',
'HTR6',
'HTR4',
'PRKACG',
'LIPE',
'GRIN2B',
'GRIN2A',
'SOX9',
'FFAR2',
'PRKACB',
'PRKACA',
'RHOA',
'GABBR2',
'JUN',
'GABBR1',
'FSHB',
'PTCH1',
'BRAF',
'NFATC1',
'VAV1',
'VAV2',
'VAV3',
'FXYD1',
'FXYD2',
'FSHR',
'CAMK4',
'RAPGEF3',
'RAPGEF4',
'GIPR',
'ADRB1',
'ADRB2',
'MC2R',
'RAP1A',
'RAP1B',
'RRAS2',
'RRAS',
'GPR119',
'PPARA',
'FOS',
'GHRL',
'RYR2',
'PTGER2',
'PTGER3',
'GNAI1',
'GLI1',
'GNAI2',
'GNAI3',
'GLI3',
'EP300',
'NPY',
'RAC3',
'RAC1',
'RAC2',
'NPY1R',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'PPP1CA',
'GRIN1',
'PPP1CB',
'ADCY10',
'RAF1',
'RELA',
'CHRM1',
'ROCK1',
'CHRM2',
'ROCK2',
'SUCNR1',
'ATP1A4',
'ATP1A3',
'ATP1A2',
'ATP1A1',
'SLC9A1',
'PPP1CC',
'PAK1',
'ADORA1',
'GHSR',
'MAP2K2',
'F2R',
'MAP2K1',
'NFKB1',
'CREB3',
'CREB1',
'CNGB3',
'GNAS',
'CREB5',
'CNGB1',
'GRIA2',
'GRIA3',
'GRIA1',
'CACNA1C',
'CACNA1D',
'CACNA1F',
'HCAR3',
'HCAR1',
'HCAR2',
'CACNA1S',
'GRIA4',
'ABCC4',
'PPP1R12A',
'HTR1F',
'BDNF',
'HTR1D',
'HTR1E',
'ARAP3',
'HTR1B',
'SSTR1',
'SSTR2',
'HTR1A',
'SSTR5',
'NFKBIA',
'PIK3CB',
'ACOX3',
'PIK3CA',
'ACOX1',
'ADORA2A',
'PDE3B',
'PDE3A',
'NPR1',
'GLP1R',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'MLLT4',
'PLD2',
'PLD1',
'PDE4C',
'CNGA2',
'PDE4B',
'CNGA3',
'DRD1',
'PDE4A',
'CNGA4',
'AMH',
'DRD2',
'DRD5',
'CNGA1',
'PDE4D',
'ATP2B4',
'ATP2B3',
'ATP2B2',
'ATP2B1',
'TIAM1',
'TSHR',
'HCN2',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'ATP2A2',
'PIK3CD',
'PIK3CG',
'PLN',
'EDNRA',
'MAPK9',
'MAPK8',
'MAPK3',
'TNNI3',
'MAPK1',
'CAMK2G'],
'Regulation of lipolysis in adipocytes Homo sapiens hsa04923': ['NPY1R',
'PIK3CB',
'PIK3CA',
'PDE3B',
'MGLL',
'NPR1',
'ADCY1',
'ABHD5',
'ADCY5',
'PIK3R5',
'AQP7',
'ADCY4',
'ADRB1',
'ADCY3',
'ADRB2',
'PIK3R3',
'ADCY2',
'ADRB3',
'PIK3R2',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'AKT3',
'AKT1',
'AKT2',
'ADORA1',
'PRKG2',
'PRKG1',
'INSR',
'PLIN1',
'TSHR',
'PLA2G16',
'FABP4',
'PIK3R1',
'GNAS',
'PNPLA2',
'IRS1',
'IRS2',
'PTGER3',
'PIK3CD',
'IRS4',
'INS',
'GNAI1',
'GNAI2',
'PTGS1',
'PTGS2',
'GNAI3',
'PIK3CG',
'PRKACG',
'LIPE',
'NPY',
'PRKACB',
'CGA',
'PRKACA',
'TSHB'],
'Platelet activation Homo sapiens hsa04611': ['GUCY1A3',
'GUCY1A2',
'PPP1CA',
'MAPK13',
'PPP1CB',
'MAPK14',
'COL1A2',
'MAPK11',
'COL1A1',
'MAPK12',
'STIM1',
'ORAI1',
'TLN2',
'TLN1',
'ROCK1',
'ROCK2',
'ADCY1',
'ITGA2B',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'ADCY8',
'ADCY7',
'MYL12B',
'ADCY6',
'ARHGAP35',
'PPP1CC',
'ACTB',
'AKT3',
'AKT1',
'AKT2',
'ARHGEF12',
'PRKCI',
'F2R',
'PLA2G4E',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'VASP',
'MYL12A',
'PRKCZ',
'VAMP8',
'PIK3R1',
'TBXAS1',
'GNAQ',
'BTK',
'GNAS',
'FERMT3',
'GUCY1B3',
'ACTG1',
'RASGRP2',
'MYLK',
'PRKACG',
'RASGRP1',
'PLCG2',
'PRKACB',
'PRKACA',
'LYN',
'RHOA',
'PPP1R12A',
'ITGA2',
'GP5',
'GP6',
'GP9',
'APBB1IP',
'FCGR2A',
'COL3A1',
'PIK3CB',
'PIK3CA',
'LCP2',
'ARHGEF1',
'SNAP23',
'ITPR2',
'PIK3R5',
'ITPR3',
'PIK3R3',
'PIK3R2',
'ITPR1',
'RAP1A',
'RAP1B',
'TBXA2R',
'P2RY1',
'FCER1G',
'FGA',
'PRKG2',
'PRKG1',
'FGB',
'P2RY12',
'FGG',
'NOS3',
'SYK',
'VWF',
'PTGIR',
'GP1BB',
'GP1BA',
'PLCB4',
'P2RX1',
'JMJD7-PLA2G4B',
'PLCB2',
'PLCB3',
'F2RL3',
'PLCB1',
'MYLK2',
'MYLK3',
'ITGB1',
'SRC',
'ITGB3',
'PIK3CD',
'GNAI1',
'MYLK4',
'GNAI2',
'PTGS1',
'GNAI3',
'PIK3CG',
'GNA13',
'MAPK3',
'MAPK1',
'FYN'],
'Chemokine signaling pathway Homo sapiens hsa04062': ['CXCL10',
'CXCL11',
'CXCL12',
'CXCL13',
'ELMO1',
'NCF1',
'PF4',
'RAF1',
'RELA',
'ROCK1',
'ROCK2',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'CXCL14',
'ADCY8',
'FOXO3',
'ADCY7',
'CXCL16',
'ADCY6',
'CRKL',
'GNG2',
'NRAS',
'GNG4',
'GNG3',
'PAK1',
'GNG5',
'PREX1',
'AKT3',
'GNG8',
'GNG7',
'AKT1',
'AKT2',
'XCR1',
'STAT5B',
'PRKCD',
'MAP2K1',
'PPBP',
'PARD3',
'PRKCB',
'NFKB1',
'PTK2',
'PRKCZ',
'PIK3R1',
'GNB1',
'GNB3',
'GNB2',
'GNB5',
'GNB4',
'GRB2',
'PXN',
'CCL4L1',
'CCL4L2',
'RASGRP2',
'PRKACG',
'GNG11',
'GNG10',
'PRKACB',
'PRKACA',
'CCR10',
'CCL26',
'CCR2',
'LYN',
'RHOA',
'CCR1',
'CCL25',
'CCL24',
'CCL23',
'CCL22',
'CCL21',
'XCL1',
'CCL20',
'BRAF',
'GNG13',
'VAV1',
'GNG12',
'VAV2',
'VAV3',
'NFKBIB',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'XCL2',
'SOS2',
'DOCK2',
'ITK',
'CCL28',
'BCAR1',
'SOS1',
'CCL27',
'CXCL8',
'SHC3',
'GSK3B',
'SHC4',
'CXCL9',
'CCL3L1',
'GSK3A',
'SHC1',
'SHC2',
'CCL3L3',
'PIK3R5',
'PIK3R3',
'CXCL2',
'PIK3R2',
'CXCL1',
'CX3CL1',
'CXCL3',
'CXCL6',
'CXCL5',
'GNGT2',
'GRK1',
'GNGT1',
'RAP1A',
'GRK4',
'RAP1B',
'GRK6',
'GRK5',
'GRK7',
'CCR9',
'CCR8',
'CCR7',
'CCR6',
'CCR5',
'CCR4',
'PF4V1',
'CCR3',
'STAT1',
'STAT2',
'CHUK',
'STAT3',
'HCK',
'TIAM1',
'CDC42',
'FGR',
'PLCB4',
'CRK',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'CCL15',
'CCL14',
'SRC',
'CCL13',
'CCL11',
'CX3CR1',
'CXCR6',
'WAS',
'CXCR5',
'WASL',
'PIK3CD',
'ARRB2',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'IKBKB',
'CCL8',
'CXCR2',
'CCL7',
'CXCR1',
'ARRB1',
'CXCR4',
'ADRBK2',
'CXCR3',
'CCL5',
'ADRBK1',
'PTK2B',
'MAPK3',
'CCL4',
'CCL3',
'HRAS',
'MAPK1',
'RAC1',
'CCL2',
'RAC2',
'CCL1',
'CCL19',
'JAK3',
'IKBKG',
'CCL18',
'CCL17',
'CCL16',
'JAK2'],
'Morphine addiction Homo sapiens hsa05032': ['KCNJ5',
'GABRA3',
'KCNJ6',
'GABRA2',
'GABRQ',
'GABBR2',
'GABRA1',
'GABRP',
'GABBR1',
'KCNJ9',
'GABRA6',
'GABRA5',
'GABRA4',
'OPRM1',
'GNG13',
'GNG12',
'GNAO1',
'PDE3B',
'PDE3A',
'PDE7B',
'PDE7A',
'GABRB3',
'GABRB2',
'GABRB1',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'ADCY8',
'PDE11A',
'ADCY7',
'ADCY6',
'GNGT2',
'GNG2',
'GNGT1',
'GABRR3',
'GRK4',
'GNG4',
'GABRR2',
'GNG3',
'GABRR1',
'GRK6',
'GRK5',
'GNG5',
'GNG8',
'GNG7',
'PDE4C',
'PDE4B',
'DRD1',
'PDE4A',
'ADORA1',
'PDE8B',
'PDE8A',
'PRKCG',
'SLC32A1',
'PDE4D',
'GABRG1',
'PRKCB',
'PRKCA',
'GABRG3',
'GABRG2',
'PDE10A',
'GNB1',
'GNB3',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'PDE1C',
'CACNA1A',
'PDE1B',
'PDE1A',
'CACNA1B',
'ARRB2',
'GNAI1',
'GNAI2',
'GNAI3',
'PRKACG',
'GNG11',
'GNG10',
'ARRB1',
'ADRBK2',
'ADRBK1',
'PDE2A',
'PRKACB',
'GABRE',
'KCNJ3',
'GABRD',
'PRKACA'],
'GABAergic synapse Homo sapiens hsa04727': ['GABRA3',
'KCNJ6',
'GABRA2',
'GABRQ',
'PLCL1',
'GABBR2',
'GABRA1',
'GABRP',
'SLC12A5',
'GABBR1',
'GABRA6',
'GABRA5',
'GABRA4',
'GNG13',
'GNG12',
'GNAO1',
'HAP1',
'GABRB3',
'GABRB2',
'GLS2',
'GABRB1',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'GLS',
'ADCY8',
'ABAT',
'ADCY7',
'ADCY6',
'GNGT2',
'GNG2',
'GNGT1',
'GABRR3',
'GNG4',
'GABRR2',
'GNG3',
'GABRR1',
'GNG5',
'GNG8',
'GNG7',
'PRKCG',
'NSF',
'GABARAPL2',
'SLC38A2',
'GABARAPL1',
'SLC38A1',
'SLC32A1',
'GAD2',
'GAD1',
'GABRG1',
'SLC6A13',
'PRKCB',
'PRKCA',
'SLC6A11',
'GABRG3',
'GABRG2',
'GNB1',
'GNB3',
'GNB2',
'GNB5',
'GNB4',
'GABARAP',
'SRC',
'CACNA1A',
'CACNA1C',
'CACNA1B',
'CACNA1D',
'SLC6A1',
'TRAK2',
'GNAI1',
'CACNA1F',
'GNAI2',
'GNAI3',
'GPHN',
'PRKACG',
'GNG11',
'GNG10',
'CACNA1S',
'GLUL',
'PRKACB',
'GABRE',
'SLC38A3',
'GABRD',
'PRKACA',
'SLC38A5'],
'Retrograde endocannabinoid signaling Homo sapiens hsa04723': ['GABRQ',
'GABRP',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'GNG2',
'GNG4',
'GNG3',
'GNG5',
'GNG8',
'GNG7',
'PRKCG',
'PRKCB',
'PRKCA',
'GNB1',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNB4',
'GRIA2',
'FAAH',
'GRIA3',
'GRIA1',
'CACNA1A',
'NAPEPLD',
'CACNA1C',
'CACNA1B',
'CACNA1D',
'CACNA1F',
'PRKACG',
'GNG11',
'GNG10',
'RIMS1',
'CACNA1S',
'PRKACB',
'GRIA4',
'PRKACA',
'KCNJ5',
'GABRA3',
'KCNJ6',
'GABRA2',
'GABRA1',
'KCNJ9',
'GABRA6',
'GABRA5',
'GABRA4',
'GNG13',
'GNG12',
'GNAO1',
'MGLL',
'GABRB3',
'DAGLA',
'GABRB2',
'DAGLB',
'GABRB1',
'ITPR2',
'ITPR3',
'ABHD6',
'ITPR1',
'GNGT2',
'GNGT1',
'GABRR3',
'GABRR2',
'GABRR1',
'SLC32A1',
'GABRG1',
'GABRG3',
'GABRG2',
'PLCB4',
'PLCB2',
'PLCB3',
'PLCB1',
'GNAI1',
'GNAI2',
'PTGS2',
'GNAI3',
'GRM1',
'MAPK9',
'MAPK8',
'GRM5',
'CNR1',
'MAPK3',
'SLC17A6',
'SLC17A7',
'MAPK1',
'SLC17A8',
'GABRE',
'KCNJ3',
'GABRD'],
'Glutamatergic synapse Homo sapiens hsa04724': ['HOMER2',
'HOMER3',
'HOMER1',
'GRIN2D',
'GRIN2C',
'GRIN1',
'GRIN3A',
'GRIN3B',
'GLS2',
'ADCY1',
'SLC1A1',
'SLC1A2',
'ADCY5',
'SLC1A3',
'ADCY4',
'ADCY3',
'ADCY2',
'SLC1A6',
'ADCY9',
'SLC1A7',
'GLS',
'ADCY8',
'ADCY7',
'ADCY6',
'GNG2',
'GNG4',
'GNG3',
'GNG5',
'GNG8',
'GNG7',
'PRKCG',
'SLC38A2',
'SLC38A1',
'PLA2G4E',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'GNB1',
'DLG4',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'GRIA2',
'GRIA3',
'GRIA1',
'CACNA1A',
'CACNA1C',
'CACNA1D',
'PRKACG',
'PPP3R1',
'PPP3R2',
'GNG11',
'GRIN2B',
'GNG10',
'GRIN2A',
'GLUL',
'PRKACB',
'SLC38A3',
'GRIA4',
'PRKACA',
'GNG13',
'GNG12',
'SHANK1',
'GNAO1',
'SHANK3',
'SHANK2',
'ITPR2',
'GRIK4',
'ITPR3',
'GRIK5',
'GRIK2',
'GRIK3',
'PLD2',
'GRIK1',
'PLD1',
'ITPR1',
'PPP3CA',
'GNGT2',
'PPP3CB',
'GNGT1',
'PPP3CC',
'TRPC1',
'DLGAP1',
'PLCB4',
'JMJD7-PLA2G4B',
'PLCB2',
'PLCB3',
'PLCB1',
'GNAI1',
'GNAI2',
'GRM2',
'GNAI3',
'GRM1',
'GRM4',
'GRM3',
'GRM6',
'GRM5',
'GRM8',
'GRM7',
'ADRBK2',
'ADRBK1',
'MAPK3',
'SLC17A6',
'SLC17A7',
'MAPK1',
'SLC17A8',
'KCNJ3'],
'Circadian entrainment Homo sapiens hsa04713': ['KCNJ5',
'GUCY1A3',
'KCNJ6',
'GUCY1A2',
'KCNJ9',
'GNG13',
'GRIN2D',
'GNG12',
'GRIN2C',
'GRIN1',
'MTNR1B',
'MTNR1A',
'GNAO1',
'CALM2',
'CALM3',
'ADCY10',
'CALM1',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'ITPR3',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'ITPR1',
'GNGT2',
'GNG2',
'GNGT1',
'GNG4',
'RASD1',
'GNG3',
'GNG5',
'GNG8',
'GNG7',
'PRKG2',
'PRKG1',
'PRKCG',
'FOS',
'PRKCB',
'PRKCA',
'PER3',
'PER2',
'PLCB4',
'CREB1',
'GNB1',
'NOS1AP',
'PER1',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'PLCB2',
'PLCB3',
'PLCB1',
'RYR2',
'GRIA2',
'CAMK2D',
'RYR3',
'GRIA3',
'GUCY1B3',
'RYR1',
'GRIA1',
'CAMK2A',
'CAMK2B',
'CACNA1C',
'CACNA1D',
'CACNA1G',
'GNAI1',
'ADCYAP1R1',
'GNAI2',
'CACNA1I',
'GNAI3',
'CACNA1H',
'RPS6KA5',
'PRKACG',
'GNG11',
'GRIN2B',
'GNG10',
'GRIN2A',
'MAPK3',
'MAPK1',
'NOS1',
'PRKACB',
'CAMK2G',
'KCNJ3',
'GRIA4',
'PRKACA'],
'Dopaminergic synapse Homo sapiens hsa04728': ['PPP2R1A',
'PPP1CA',
'MAPK13',
'PPP1CB',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'CALM2',
'CALM3',
'CALM1',
'ATF2',
'CALML6',
'ATF6B',
'ADCY5',
'CALML3',
'CALML5',
'COMT',
'ARNTL',
'PPP1CC',
'KIF5A',
'GNG2',
'CREB3L1',
'GNG4',
'GNG3',
'CREB3L4',
'GNG5',
'CREB3L2',
'AKT3',
'KIF5C',
'GNG8',
'CREB3L3',
'KIF5B',
'GNG7',
'AKT1',
'AKT2',
'PRKCG',
'PRKCB',
'PRKCA',
'GNAL',
'CREB3',
'CREB1',
'GNB1',
'PPP1R1B',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'ATF4',
'CREB5',
'GRIA2',
'GRIA3',
'GRIA1',
'CACNA1A',
'CACNA1C',
'CACNA1B',
'CACNA1D',
'SLC6A3',
'PRKACG',
'GNG11',
'GRIN2B',
'GNG10',
'GRIN2A',
'PRKACB',
'SCN1A',
'GRIA4',
'PRKACA',
'KCNJ5',
'KCNJ6',
'KCNJ9',
'PPP2R5C',
'PPP2R5B',
'PPP2R5E',
'PPP2R5D',
'GNG13',
'GNG12',
'PPP2R5A',
'TH',
'CALY',
'GNAO1',
'GSK3B',
'GSK3A',
'MAOB',
'MAOA',
'ITPR2',
'ITPR3',
'ITPR1',
'PPP3CA',
'GNGT2',
'PPP3CB',
'GNGT1',
'PPP3CC',
'DRD1',
'DRD2',
'SLC18A1',
'DRD3',
'SLC18A2',
'DRD4',
'DRD5',
'PPP2R3A',
'FOS',
'PPP2R3C',
'PPP2R3B',
'PPP2CA',
'PLCB4',
'PPP2R2D',
'PPP2R2C',
'PLCB2',
'PLCB3',
'CLOCK',
'PLCB1',
'CAMK2D',
'DDC',
'CAMK2A',
'CAMK2B',
'PPP2R2B',
'ARRB2',
'PPP2R2A',
'GNAI1',
'GNAI2',
'GNAI3',
'PPP2CB',
'MAPK9',
'MAPK8',
'PPP2R1B',
'CAMK2G',
'KCNJ3'],
'Serotonergic synapse Homo sapiens hsa04726': ['HTR5A',
'CYP2C9',
'CYP2C8',
'RAF1',
'APP',
'ADCY5',
'ARAF',
'ALOX12B',
'GNG2',
'NRAS',
'GNG4',
'CYP4X1',
'GNG3',
'GNG5',
'GNG8',
'CYP2D6',
'GNG7',
'ALOX5',
'PRKCG',
'KCND2',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'ALOX15B',
'GNB1',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNAS',
'GNB4',
'CACNA1A',
'CACNA1C',
'CACNA1B',
'CACNA1D',
'CACNA1F',
'HTR6',
'CYP2C19',
'SLC6A4',
'CYP2C18',
'HTR4',
'PRKACG',
'GNG11',
'HTR7',
'GNG10',
'CACNA1S',
'KCNN2',
'PRKACB',
'PRKACA',
'CYP2J2',
'KCNJ5',
'KCNJ6',
'DUSP1',
'KCNJ9',
'HTR1F',
'HTR1D',
'HTR1E',
'HTR1B',
'BRAF',
'HTR1A',
'GNG13',
'GNG12',
'GNAO1',
'RAPGEF3',
'GABRB3',
'GABRB2',
'TPH2',
'GABRB1',
'TPH1',
'MAOB',
'MAOA',
'ITPR2',
'HTR2C',
'ALOX15',
'ITPR3',
'HTR2A',
'HTR2B',
'ALOX12',
'ITPR1',
'GNGT2',
'GNGT1',
'TRPC1',
'CASP3',
'SLC18A1',
'SLC18A2',
'HTR3D',
'HTR3E',
'HTR3B',
'HTR3C',
'HTR3A',
'PLCB4',
'JMJD7-PLA2G4B',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'DDC',
'GNAI1',
'GNAI2',
'PTGS1',
'PTGS2',
'GNAI3',
'MAPK3',
'HRAS',
'MAPK1',
'KCNJ3'],
'Cholinergic synapse Homo sapiens hsa04725': ['CHRNB2',
'CHRNB4',
'SLC5A7',
'CHRM3',
'CHRM4',
'CHRM1',
'CHRNA4',
'CHRM2',
'CHRNA3',
'ADCY1',
'CHRNA6',
'CHRM5',
'CHRNA7',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'GNG2',
'CREB3L1',
'NRAS',
'GNG4',
'GNG3',
'CREB3L4',
'GNG5',
'CREB3L2',
'AKT3',
'GNG8',
'CREB3L3',
'GNG7',
'AKT1',
'AKT2',
'PRKCG',
'MAP2K1',
'PRKCB',
'PRKCA',
'CREB3',
'CREB1',
'PIK3R1',
'GNB1',
'GNB3',
'GNAQ',
'GNB2',
'GNB5',
'GNB4',
'ATF4',
'CREB5',
'CACNA1A',
'CHAT',
'CACNA1C',
'CACNA1B',
'CACNA1D',
'CACNA1F',
'PRKACG',
'GNG11',
'GNG10',
'CACNA1S',
'PRKACB',
'PRKACA',
'KCNJ6',
'KCNJ12',
'KCNJ14',
'GNG13',
'GNG12',
'PIK3CB',
'PIK3CA',
'GNAO1',
'CAMK4',
'BCL2',
'ACHE',
'ITPR2',
'PIK3R5',
'ITPR3',
'PIK3R3',
'PIK3R2',
'ITPR1',
'GNGT2',
'GNGT1',
'SLC18A3',
'FOS',
'PLCB4',
'KCNQ1',
'KCNQ2',
'KCNQ3',
'KCNQ4',
'KCNQ5',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'PIK3CD',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'GNA11',
'MAPK3',
'HRAS',
'MAPK1',
'FYN',
'CAMK2G',
'KCNJ2',
'KCNJ3',
'KCNJ4',
'JAK2'],
'Estrogen signaling pathway Homo sapiens hsa04915': ['HSPA1L',
'HSPA1A',
'CALM2',
'FKBP5',
'CALM3',
'FKBP4',
'CALM1',
'RAF1',
'HSPA1B',
'ATF2',
'ADCY1',
'CALML6',
'ATF6B',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'EGFR',
'ADCY7',
'HSP90B1',
'ADCY6',
'CREB3L1',
'NRAS',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'MAP2K2',
'PRKCD',
'MAP2K1',
'ESR1',
'ESR2',
'CREB3',
'CREB1',
'PIK3R1',
'GNAQ',
'GNAS',
'GRB2',
'ATF4',
'CREB5',
'PRKACG',
'PRKACB',
'PRKACA',
'KCNJ5',
'KCNJ6',
'GABBR2',
'HSP90AA1',
'JUN',
'GABBR1',
'KCNJ9',
'HSPA6',
'MMP2',
'HSPA8',
'HSPA2',
'OPRM1',
'MMP9',
'SP1',
'PIK3CB',
'PIK3CA',
'GNAO1',
'SOS2',
'SOS1',
'SHC3',
'SHC4',
'SHC1',
'SHC2',
'ITPR2',
'PIK3R5',
'ITPR3',
'PIK3R3',
'PIK3R2',
'ITPR1',
'GPER1',
'NOS3',
'FOS',
'PLCB4',
'KRAS',
'PLCB2',
'HBEGF',
'PLCB3',
'PLCB1',
'SRC',
'HSP90AB1',
'PIK3CD',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'GRM1',
'MAPK3',
'HRAS',
'MAPK1',
'KCNJ3'],
'Aldosterone synthesis and secretion Homo sapiens hsa04925': ['HSD3B1',
'HSD3B2',
'CYP11B2',
'CAMK4',
'AGTR1',
'CAMK1',
'ORAI1',
'CALM2',
'CALM3',
'KCNK3',
'CALM1',
'ATF2',
'DAGLA',
'KCNK9',
'ATF1',
'DAGLB',
'NPR1',
'ADCY1',
'CALML6',
'ATF6B',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'ITPR1',
'CREB3L1',
'MC2R',
'CREB3L4',
'CREB3L2',
'CREB3L3',
'LDLR',
'PRKCG',
'CAMK1D',
'PRKCE',
'PRKCB',
'PRKCA',
'CREB3',
'NR4A2',
'PLCB4',
'CREB1',
'CYP21A2',
'GNAQ',
'STAR',
'PRKD1',
'GNAS',
'PRKD3',
'PRKD2',
'PLCB2',
'PLCB3',
'CAMK1G',
'ATF4',
'CREB5',
'PLCB1',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'CACNA1C',
'CACNA1D',
'CACNA1G',
'CACNA1F',
'CACNA1I',
'NR4A1',
'CACNA1H',
'PRKACG',
'LIPE',
'GNA11',
'CYP11A1',
'CACNA1S',
'PDE2A',
'PRKACB',
'CAMK2G',
'SCARB1',
'PRKACA'],
'Insulin secretion Homo sapiens hsa04911': ['KCNJ11',
'ABCC8',
'FFAR1',
'ATP1B4',
'ATP1B3',
'GCG',
'ATP1B2',
'ATP1B1',
'GCK',
'FXYD2',
'RAPGEF4',
'STX1A',
'SNAP25',
'ATF2',
'CHRM3',
'ADCY1',
'ATF6B',
'GLP1R',
'ADCY5',
'ADCY4',
'ITPR3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'ATP1A2',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'ADCY6',
'CREB3L1',
'CREB3L4',
'CCKAR',
'CREB3L2',
'CREB3L3',
'GPR119',
'PRKCG',
'PDX1',
'PRKCB',
'PRKCA',
'GIP',
'ADCYAP1',
'CREB3',
'KCNU1',
'PLCB4',
'CREB1',
'KCNMA1',
'GNAQ',
'GNAS',
'VAMP2',
'PLCB2',
'PLCB3',
'ATF4',
'CREB5',
'PLCB1',
'RYR2',
'CAMK2D',
'RAB3A',
'CAMK2A',
'CAMK2B',
'SLC2A1',
'CACNA1C',
'SLC2A2',
'CACNA1D',
'INS',
'CACNA1F',
'ADCYAP1R1',
'PCLO',
'RIMS2',
'PRKACG',
'KCNMB1',
'GNA11',
'KCNMB2',
'KCNMB3',
'KCNN1',
'KCNMB4',
'CACNA1S',
'KCNN2',
'KCNN3',
'KCNN4',
'PRKACB',
'CAMK2G',
'TRPM4',
'PRKACA'],
'Thyroid hormone synthesis Homo sapiens hsa04918': ['GPX1',
'GPX3',
'GPX2',
'GPX5',
'GSR',
'HSPA5',
'GPX7',
'GPX6',
'GPX8',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'TG',
'PAX8',
'FXYD2',
'SLC26A4',
'ATF2',
'ADCY1',
'LRP2',
'ATF6B',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'ATP1A2',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'HSP90B1',
'SLC5A5',
'ADCY6',
'ITPR1',
'CREB3L1',
'DUOX2',
'IYD',
'CREB3L4',
'CREB3L2',
'DUOXA2',
'CREB3L3',
'PDIA4',
'PRKCG',
'PRKCB',
'PRKCA',
'TSHR',
'CREB3',
'PLCB4',
'CREB1',
'GNAQ',
'CANX',
'GNAS',
'PLCB2',
'PLCB3',
'ATF4',
'CREB5',
'PLCB1',
'ASGR1',
'TTF2',
'TTF1',
'ASGR2',
'PRKACG',
'TPO',
'PRKACB',
'CGA',
'PRKACA',
'TSHB'],
'Gastric acid secretion Homo sapiens hsa04971': ['KCNJ10',
'KCNJ15',
'KCNJ16',
'ATP1B4',
'ATP1B3',
'SSTR2',
'ATP1B2',
'ATP1B1',
'SLC9A4',
'SST',
'CALM2',
'KCNK2',
'CALM3',
'SLC26A7',
'CALM1',
'CHRM3',
'ADCY1',
'CALML6',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'CALML3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'CALML5',
'ATP1A2',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'SLC9A1',
'ADCY6',
'ITPR1',
'ACTB',
'HRH2',
'CA2',
'PRKCG',
'KCNK10',
'PRKCB',
'PRKCA',
'ATP4B',
'PLCB4',
'ATP4A',
'KCNQ1',
'CCKBR',
'GNAQ',
'GNAS',
'PLCB2',
'PLCB3',
'EZR',
'PLCB1',
'CFTR',
'MYLK2',
'MYLK3',
'CAMK2D',
'KCNE2',
'CAMK2A',
'CAMK2B',
'SLC4A2',
'GNAI1',
'MYLK',
'MYLK4',
'GNAI2',
'GNAI3',
'PRKACG',
'GAST',
'PRKACB',
'CAMK2G',
'KCNJ1',
'KCNJ2',
'PRKACA'],
'Salivary secretion Homo sapiens hsa04970': ['GUCY1A3',
'GUCY1A2',
'AMY1A',
'AMY1B',
'AMY1C',
'SLC12A2',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'LYZ',
'BST1',
'FXYD2',
'TRPV6',
'CALM2',
'CALM3',
'CALM1',
'CHRM3',
'ADCY1',
'CALML6',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'CALML3',
'ADRB1',
'ATP1A4',
'ADCY3',
'ADRB2',
'ATP1A3',
'AQP5',
'ADCY2',
'CALML5',
'ADRA1D',
'ADRB3',
'ATP1A2',
'STATH',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADRA1B',
'ADCY7',
'ADRA1A',
'SLC9A1',
'PRH2',
'ADCY6',
'ITPR1',
'BEST2',
'PRH1',
'CD38',
'PRKG2',
'PRKG1',
'MUC7',
'CAMP',
'PRKCG',
'MUC5B',
'ATP2B4',
'PRKCB',
'ATP2B3',
'PRKCA',
'ATP2B2',
'ATP2B1',
'PLCB4',
'KCNMA1',
'GNAQ',
'GNAS',
'VAMP2',
'PLCB2',
'PLCB3',
'PLCB1',
'RYR3',
'GUCY1B3',
'SLC4A2',
'LPO',
'CST5',
'HTN1',
'CST4',
'PRKACG',
'CST3',
'HTN3',
'CST2',
'CST1',
'PRB2',
'PRB1',
'DMBT1',
'NOS1',
'KCNN4',
'PRKACB',
'PRKACA'],
'Pancreatic secretion Homo sapiens hsa04972': ['RHOA',
'PLA2G2E',
'PLA2G2F',
'PLA2G2C',
'PLA2G2D',
'PLA2G2A',
'SLC12A2',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'TPCN2',
'BST1',
'CTRL',
'FXYD2',
'CHRM3',
'PNLIPRP2',
'PRSS2',
'PRSS1',
'PNLIPRP1',
'ADCY1',
'ADCY5',
'ITPR2',
'ADCY4',
'ITPR3',
'ATP1A4',
'ADCY3',
'ATP1A3',
'ADCY2',
'ATP1A2',
'ADCY9',
'ATP1A1',
'ADCY8',
'ADCY7',
'SLC9A1',
'ADCY6',
'ITPR1',
'RAP1A',
'CA2',
'RAP1B',
'CCKAR',
'TRPC1',
'CD38',
'PRSS3',
'PRKCG',
'CPA3',
'CELA2A',
'PLA2G12A',
'CELA2B',
'CPA2',
'PLA2G12B',
'CPA1',
'CEL',
'ATP2B4',
'RAB27B',
'PRKCB',
'ATP2B3',
'PRKCA',
'ATP2B2',
'SCTR',
'ATP2B1',
'RAB11A',
'PLCB4',
'KCNQ1',
'KCNMA1',
'PLA2G10',
'GNAQ',
'CTRB1',
'GNAS',
'PLCB2',
'PLCB3',
'PLCB1',
'CFTR',
'PNLIP',
'RYR2',
'CELA3A',
'CELA3B',
'RAB3D',
'SLC26A3',
'CPB2',
'AMY2A',
'CPB1',
'AMY2B',
'PLA2G1B',
'PLA2G3',
'ATP2A3',
'ATP2A2',
'SLC4A2',
'PLA2G5',
'ATP2A1',
'SLC4A4',
'RAB8A',
'CLCA2',
'RAC1',
'CLCA1',
'CLCA4'],
'Endocrine and other factor-regulated calcium reabsorption Homo sapiens hsa04961': ['KL',
'PRKCG',
'VDR',
'AP2B1',
'PRKCB',
'ATP1B4',
'PRKCA',
'ATP1B3',
'ATP2B1',
'ATP1B2',
'ESR1',
'ATP1B1',
'RAB11A',
'DNM1',
'DNM2',
'DNM3',
'PLCB4',
'TRPV5',
'GNAQ',
'FXYD2',
'GNAS',
'PLCB2',
'PLCB3',
'PLCB1',
'KLK2',
'KLK1',
'CLTC',
'ATP1A4',
'CLTB',
'ATP1A3',
'AP2A2',
'CLTA',
'PTH1R',
'ATP1A2',
'AP2A1',
'ADCY9',
'ATP1A1',
'SLC8A1',
'ADCY6',
'PRKACG',
'CALB1',
'CLTCL1',
'AP2S1',
'BDKRB2',
'PRKACB',
'PRKACA',
'AP2M1'],
'Bile secretion Homo sapiens hsa04976': ['ABCG8',
'ABCC4',
'ABCC2',
'ABCC3',
'SLC10A1',
'SLC10A2',
'ATP1B4',
'SLCO1B7',
'SLC51A',
'ATP1B3',
'SLC51B',
'ATP1B2',
'ATP1B1',
'SLC9A3',
'FXYD2',
'ABCG5',
'SLC22A8',
'ABCG2',
'ABCB4',
'ABCB1',
'ADCY1',
'AQP9',
'ADCY5',
'ADCY4',
'ATP1A4',
'AQP8',
'ADCY3',
'ATP1A3',
'SLC5A1',
'ADCY2',
'ATP1A2',
'CYP3A4',
'ADCY9',
'ATP1A1',
'CYP7A1',
'ADCY8',
'AQP4',
'ADCY7',
'SLC9A1',
'AQP1',
'ADCY6',
'SULT2A1',
'SLCO1B1',
'RXRA',
'CA2',
'SLCO1B3',
'LDLR',
'EPHX1',
'NR1H4',
'NR0B2',
'SCTR',
'BAAT',
'NCEH1',
'ABCB11',
'SLCO1A2',
'GNAS',
'UGT2B4',
'CFTR',
'SLC27A5',
'SLC22A7',
'SLC22A1',
'SLC2A1',
'SLC4A2',
'HMGCR',
'SLC4A4',
'SLC4A5',
'PRKACG',
'KCNN2',
'PRKACB',
'SCARB1',
'PRKACA'],
'Ovarian steroidogenesis Homo sapiens hsa04913': ['HSD3B1',
'FSHB',
'HSD3B2',
'BMP6',
'FSHR',
'CYP1A1',
'ACOT2',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'HSD17B7',
'ADCY9',
'ADCY8',
'ADCY7',
'BMP15',
'ADCY6',
'HSD17B1',
'HSD17B2',
'ALOX5',
'CYP1B1',
'LDLR',
'INSR',
'LHCGR',
'PLA2G4E',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'AKR1C3',
'IGF1',
'GDF9',
'STAR',
'JMJD7-PLA2G4B',
'GNAS',
'LHB',
'INS',
'IGF1R',
'CYP19A1',
'PTGS2',
'CYP17A1',
'PRKACG',
'CYP11A1',
'PRKACB',
'CGA',
'SCARB1',
'PRKACA',
'CYP2J2'],
'Vasopressin-regulated water reabsorption Homo sapiens hsa04962': ['DYNC2H1',
'NSF',
'DYNLL1',
'AVPR2',
'DYNLL2',
'RAB11A',
'RAB11B',
'CREB3',
'DYNC1LI1',
'DYNC1LI2',
'CREB1',
'GNAS',
'VAMP2',
'AVP',
'RAB5A',
'RAB5B',
'CREB5',
'DYNC1H1',
'DCTN6',
'RAB5C',
'DCTN2',
'DCTN5',
'DCTN4',
'ADCY3',
'DCTN1',
'ARHGDIG',
'ADCY9',
'AQP3',
'AQP4',
'ADCY6',
'AQP2',
'PRKACG',
'CREB3L1',
'ARHGDIA',
'CREB3L4',
'CREB3L2',
'ARHGDIB',
'CREB3L3',
'DYNC2LI1',
'STX4',
'PRKACB',
'DYNC1I2',
'PRKACA',
'DYNC1I1'],
'Cocaine addiction Homo sapiens hsa05030': ['JUN',
'BDNF',
'GRIN2D',
'PDYN',
'GRIN2C',
'GRIN1',
'GRIN3A',
'TH',
'GRIN3B',
'CDK5',
'ATF2',
'RELA',
'GPSM1',
'ATF6B',
'MAOB',
'MAOA',
'ADCY5',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'CREB3L3',
'DRD1',
'DRD2',
'SLC18A1',
'SLC18A2',
'NFKB1',
'CREB3',
'CREB1',
'PPP1R1B',
'DLG4',
'FOSB',
'GNAS',
'CDK5R1',
'ATF4',
'CREB5',
'GRIA2',
'DDC',
'GNAI1',
'SLC6A3',
'GNAI2',
'GRM2',
'GNAI3',
'PRKACG',
'GRM3',
'GRIN2B',
'GRIN2A',
'PRKACB',
'RGS9',
'PRKACA'],
'Amphetamine addiction Homo sapiens hsa05031': ['JUN',
'SIRT1',
'GRIN2D',
'PDYN',
'GRIN2C',
'PPP1CA',
'GRIN1',
'PPP1CB',
'GRIN3A',
'TH',
'GRIN3B',
'CAMK4',
'CALM2',
'CALM3',
'CALM1',
'STX1A',
'ATF2',
'CALML6',
'ATF6B',
'MAOB',
'MAOA',
'ADCY5',
'CALML3',
'CALML5',
'PPP1CC',
'PPP3CA',
'CREB3L1',
'PPP3CB',
'PPP3CC',
'CREB3L4',
'CREB3L2',
'CREB3L3',
'DRD1',
'SLC18A1',
'SLC18A2',
'PRKCG',
'FOS',
'PRKCB',
'PRKCA',
'CREB3',
'ARC',
'CREB1',
'PPP1R1B',
'FOSB',
'GNAS',
'ATF4',
'CREB5',
'GRIA2',
'CAMK2D',
'GRIA3',
'DDC',
'GRIA1',
'HDAC1',
'CAMK2A',
'CAMK2B',
'CACNA1C',
'CACNA1D',
'SLC6A3',
'PRKACG',
'PPP3R1',
'PPP3R2',
'GRIN2B',
'GRIN2A',
'PRKACB',
'CAMK2G',
'GRIA4',
'PRKACA'],
'Glucagon signaling pathway Homo sapiens hsa04922': ['G6PC',
'GCG',
'PRKAB1',
'PRKAB2',
'GCK',
'SIK2',
'CALM2',
'CALM3',
'SIK1',
'CALM1',
'ATF2',
'PRKAA2',
'CALML6',
'CRTC2',
'PDHB',
'CALML3',
'ADCY2',
'CALML5',
'PRKAA1',
'FOXO1',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'PPARGC1A',
'CREBBP',
'PHKA2',
'PHKA1',
'PHKB',
'CREB3',
'CREB1',
'GNAQ',
'GNAS',
'LDHAL6A',
'ATF4',
'CREB5',
'PFKFB1',
'LDHAL6B',
'SMEK2',
'SMEK1',
'SLC2A1',
'SLC2A2',
'PRKACG',
'PPP3R1',
'PPP3R2',
'PPP4C',
'PRKACB',
'PRKACA',
'PDHA2',
'PDHA1',
'SIRT1',
'G6PC2',
'G6PC3',
'PDE3B',
'FBP1',
'ITPR2',
'ITPR3',
'ACACB',
'ITPR1',
'ACACA',
'PPP3CA',
'PPP3CB',
'LDHC',
'PPP3CC',
'LDHB',
'LDHA',
'PCK2',
'PCK1',
'CPT1B',
'PPARA',
'CPT1A',
'PGAM1',
'PGAM2',
'GCGR',
'PRMT1',
'CPT1C',
'PKM',
'PLCB4',
'PFKL',
'PGAM4',
'PLCB2',
'PLCB3',
'PLCB1',
'CAMK2D',
'CAMK2A',
'PYGB',
'CAMK2B',
'PRKAG2',
'PYGL',
'PRKAG3',
'PRKAG1',
'PYGM',
'GYS1',
'GYS2',
'PHKG2',
'PHKG1',
'EP300',
'CAMK2G'],
'Adipocytokine signaling pathway Homo sapiens hsa04920': ['G6PC',
'ACSL3',
'ACSL1',
'PTPN11',
'ACSL6',
'ACSL5',
'ACSL4',
'PRKAB1',
'PRKAB2',
'G6PC2',
'TNFRSF1A',
'TNFRSF1B',
'NFKBIB',
'NFKBIA',
'G6PC3',
'MAPK10',
'LEP',
'AGRP',
'NFKBIE',
'RELA',
'PRKAA2',
'TRADD',
'TNF',
'ADIPOR1',
'ADIPOR2',
'PRKAA1',
'ACACB',
'SOCS3',
'RXRA',
'RXRB',
'AKT3',
'AKT1',
'AKT2',
'RXRG',
'PPARGC1A',
'PCK2',
'CD36',
'PCK1',
'ADIPOQ',
'CPT1B',
'PPARA',
'CPT1A',
'CHUK',
'STAT3',
'TRAF2',
'NFKB1',
'MTOR',
'CPT1C',
'POMC',
'ACSBG2',
'PRKCQ',
'ACSBG1',
'IRS1',
'IRS2',
'SLC2A1',
'PRKAG2',
'PRKAG3',
'SLC2A4',
'IRS4',
'PRKAG1',
'CAMKK1',
'CAMKK2',
'IKBKB',
'STK11',
'MAPK9',
'MAPK8',
'NPY',
'LEPR',
'IKBKG',
'JAK2'],
'Insulin resistance Homo sapiens hsa04931': ['G6PC',
'PTPN1',
'MGEA5',
'PRKAB1',
'PRKAB2',
'PPP1CA',
'PPP1CB',
'MAPK10',
'PPP1R3D',
'PPP1R3C',
'PPP1R3E',
'RELA',
'PRKAA2',
'SLC27A2',
'SLC27A1',
'CRTC2',
'TNF',
'PPP1R3B',
'PPP1R3A',
'PRKAA1',
'FOXO1',
'PPP1CC',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'PPARGC1A',
'PPARGC1B',
'SREBF1',
'INSR',
'PRKCD',
'PRKCE',
'PRKCB',
'NFKB1',
'CREB3',
'CREB1',
'PRKCZ',
'PIK3R1',
'MLXIPL',
'PRKCQ',
'SLC27A4',
'SLC27A3',
'CREB5',
'SLC27A6',
'SLC27A5',
'IRS1',
'IRS2',
'SLC2A1',
'SLC2A2',
'SLC2A4',
'GFPT1',
'GFPT2',
'PTPN11',
'G6PC2',
'TNFRSF1A',
'NFKBIA',
'PTPRF',
'G6PC3',
'IL6',
'PIK3CB',
'PIK3CA',
'OGT',
'GSK3B',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ACACB',
'SOCS3',
'PPP2R4',
'MLX',
'PCK2',
'CD36',
'PCK1',
'CPT1B',
'PPARA',
'CPT1A',
'NOS3',
'PDPK1',
'STAT3',
'NR1H3',
'NR1H2',
'MTOR',
'TBC1D4',
'RPS6KB2',
'RPS6KB1',
'TRIB3',
'PYGB',
'PRKAG2',
'PYGL',
'PTEN',
'PRKAG3',
'PIK3CD',
'PRKAG1',
'PYGM',
'INS',
'GYS1',
'PIK3CG',
'IKBKB',
'GYS2',
'MAPK9',
'MAPK8',
'RPS6KA6',
'RPS6KA1',
'RPS6KA3',
'RPS6KA2',
'MLXIP'],
'Insulin signaling pathway Homo sapiens hsa04910': ['G6PC',
'PTPN1',
'BAD',
'RPS6',
'TSC2',
'TSC1',
'PRKAB1',
'PRKAB2',
'PPP1CA',
'PPP1CB',
'GCK',
'MAPK10',
'PPP1R3D',
'PPP1R3C',
'PPP1R3F',
'PPP1R3E',
'CALM2',
'CALM3',
'CALM1',
'RAF1',
'PRKAA2',
'CALML6',
'CALML3',
'CBLC',
'PPP1R3B',
'CALML5',
'ARAF',
'CBLB',
'PPP1R3A',
'INPPL1',
'PRKAA1',
'FOXO1',
'PPP1CC',
'CRKL',
'NRAS',
'AKT3',
'AKT1',
'AKT2',
'PPARGC1A',
'SH2B2',
'SREBF1',
'INSR',
'MAP2K2',
'PRKCI',
'MAP2K1',
'PHKA2',
'PHKA1',
'PHKB',
'EIF4E1B',
'PRKCZ',
'PIK3R1',
'RHEB',
'PRKAR1B',
'FASN',
'PRKAR1A',
'GRB2',
'IRS1',
'IRS2',
'EIF4EBP1',
'SLC2A4',
'IRS4',
'ELK1',
'PRKACG',
'LIPE',
'PRKAR2B',
'PRKAR2A',
'FLOT2',
'INPP5K',
'FLOT1',
'PRKACB',
'PRKACA',
'BRAF',
'G6PC2',
'RHOQ',
'PTPRF',
'G6PC3',
'PIK3CB',
'PIK3CA',
'PDE3B',
'EXOC7',
'RAPGEF1',
'SOS2',
'FBP1',
'EIF4E2',
'FBP2',
'SOS1',
'SHC3',
'GSK3B',
'SHC4',
'SHC1',
'SHC2',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'HK1',
'HK3',
'ACACB',
'HK2',
'ACACA',
'SOCS3',
'SOCS4',
'SOCS1',
'SOCS2',
'MKNK1',
'MKNK2',
'EIF4E',
'PCK2',
'PCK1',
'PKLR',
'PDPK1',
'SORBS1',
'MTOR',
'RPS6KB2',
'RPS6KB1',
'HKDC1',
'CRK',
'KRAS',
'TRIP10',
'PYGB',
'PRKAG2',
'PYGL',
'PRKAG3',
'PIK3CD',
'PRKAG1',
'PYGM',
'INS',
'CBL',
'GYS1',
'PIK3CG',
'IKBKB',
'RPTOR',
'GYS2',
'MAPK9',
'MAPK8',
'PHKG2',
'PHKG1',
'MAPK3',
'HRAS',
'MAPK1'],
'Type II diabetes mellitus Homo sapiens hsa04930': ['ADIPOQ',
'INSR',
'KCNJ11',
'PRKCD',
'ABCC8',
'PKLR',
'PRKCE',
'PDX1',
'MTOR',
'MAFA',
'GCK',
'PKM',
'PRKCZ',
'MAPK10',
'PIK3CB',
'PIK3R1',
'PIK3CA',
'HKDC1',
'IRS1',
'IRS2',
'CACNA1A',
'CACNA1C',
'PIK3R5',
'SLC2A2',
'CACNA1B',
'CACNA1E',
'PIK3CD',
'PIK3R3',
'TNF',
'SLC2A4',
'CACNA1D',
'PIK3R2',
'IRS4',
'CACNA1G',
'INS',
'HK1',
'HK3',
'PIK3CG',
'HK2',
'SOCS3',
'SOCS4',
'IKBKB',
'SOCS1',
'MAPK9',
'SOCS2',
'MAPK8',
'MAPK3',
'MAPK1'],
'Longevity regulating pathway - multiple species Homo sapiens hsa04213': ['HSPA6',
'HSPA1L',
'HSPA8',
'HSPA2',
'SIRT1',
'PRKAB1',
'PRKAB2',
'PIK3CB',
'PIK3CA',
'AKT1S1',
'HSPA1A',
'HSPA1B',
'PRKAA2',
'ADCY1',
'CLPB',
'ADCY5',
'PIK3R5',
'ADCY4',
'ADCY3',
'PIK3R3',
'ADCY2',
'PIK3R2',
'ADCY9',
'ADCY8',
'PRKAA1',
'FOXO3',
'ADCY7',
'ADCY6',
'FOXO1',
'NRAS',
'AKT3',
'AKT1',
'AKT2',
'INSR',
'IGF1',
'MTOR',
'SOD1',
'SOD2',
'PIK3R1',
'RPS6KB2',
'CAT',
'RPS6KB1',
'KRAS',
'CRYAB',
'FOXA2',
'HDAC1',
'IRS1',
'HDAC2',
'IRS2',
'PRKAG2',
'PRKAG3',
'PIK3CD',
'IRS4',
'PRKAG1',
'INS',
'IGF1R',
'PIK3CG',
'PRKACG',
'RPTOR',
'EIF4EBP2',
'HRAS',
'PRKACB',
'ATG5',
'PRKACA'],
'Longevity regulating pathway - mammal Homo sapiens hsa04211': ['KL',
'TSC2',
'TSC1',
'SIRT1',
'PRKAB1',
'PRKAB2',
'ATG13',
'PIK3CB',
'PIK3CA',
'AKT1S1',
'CAMK4',
'ULK3',
'BAX',
'ULK2',
'ULK1',
'EIF4E2',
'TP53',
'ATF2',
'RELA',
'PRKAA2',
'ADCY1',
'ATF6B',
'ADCY5',
'PIK3R5',
'ADCY4',
'ADCY3',
'PIK3R3',
'ADCY2',
'PIK3R2',
'ADIPOR1',
'ADCY9',
'ADIPOR2',
'ADCY8',
'PRKAA1',
'FOXO3',
'ADCY7',
'ADCY6',
'FOXO1',
'CREB3L1',
'NRAS',
'CREB3L4',
'CREB3L2',
'AKT3',
'ATG101',
'CREB3L3',
'AKT1',
'AKT2',
'PPARGC1A',
'EIF4E',
'ADIPOQ',
'INSR',
'IGF1',
'NFKB1',
'MTOR',
'SOD2',
'CREB3',
'EIF4E1B',
'CREB1',
'PIK3R1',
'RHEB',
'RPS6KB2',
'CAT',
'RPS6KB1',
'PPARG',
'KRAS',
'ATF4',
'CREB5',
'IRS1',
'IRS2',
'EIF4EBP1',
'PRKAG2',
'EHMT1',
'PRKAG3',
'RB1CC1',
'EHMT2',
'PIK3CD',
'IRS4',
'PRKAG1',
'INS',
'CAMKK1',
'CAMKK2',
'IGF1R',
'PIK3CG',
'PRKACG',
'RPTOR',
'STK11',
'SESN1',
'SESN2',
'SESN3',
'HRAS',
'PRKACB',
'APPL1',
'ATG5',
'PRKACA'],
'AMPK signaling pathway Homo sapiens hsa04152': ['G6PC',
'RAB2A',
'PPP2R1A',
'TSC2',
'TSC1',
'PRKAB1',
'PRKAB2',
'SCD',
'LEP',
'ULK1',
'PRKAA2',
'CRTC2',
'PRKAA1',
'FOXO3',
'FOXO1',
'CREB3L1',
'CREB3L4',
'CCND1',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'MAP3K7',
'PPARGC1A',
'SREBF1',
'INSR',
'IGF1',
'EEF2',
'CREB3',
'CCNA2',
'CREB1',
'CCNA1',
'PIK3R1',
'RHEB',
'FASN',
'CREB5',
'PFKFB1',
'CFTR',
'PFKFB3',
'PFKFB2',
'PFKFB4',
'IRS1',
'IRS2',
'EIF4EBP1',
'SLC2A4',
'IRS4',
'IGF1R',
'STK11',
'EEF2K',
'LIPE',
'LEPR',
'STRADA',
'STRADB',
'PPP2R5C',
'PPP2R5B',
'PPP2R5E',
'PPP2R5D',
'SIRT1',
'G6PC2',
'PPP2R5A',
'G6PC3',
'PIK3CB',
'PIK3CA',
'AKT1S1',
'LOC101930123',
'FBP1',
'FBP2',
'CAB39L',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ADIPOR1',
'ADIPOR2',
'ELAVL1',
'ADRA1A',
'ACACB',
'ACACA',
'HNF4A',
'PCK2',
'CD36',
'PCK1',
'ADIPOQ',
'CPT1B',
'CPT1A',
'PDPK1',
'SCD5',
'PPP2R3A',
'PPP2R3C',
'PPP2R3B',
'MTOR',
'CPT1C',
'RAB11B',
'PPP2CA',
'TBC1D1',
'PFKM',
'RAB10',
'PFKL',
'PPP2R2D',
'RPS6KB2',
'PPP2R2C',
'RPS6KB1',
'RAB14',
'PPARG',
'PFKP',
'CAB39',
'PRKAG2',
'PRKAG3',
'PPP2R2B',
'PIK3CD',
'HMGCR',
'PPP2R2A',
'PRKAG1',
'INS',
'CAMKK1',
'CAMKK2',
'GYS1',
'PIK3CG',
'PPP2CB',
'RPTOR',
'GYS2',
'PPP2R1B',
'RAB8A',
'MLYCD'],
'mTOR signaling pathway Homo sapiens hsa04150': ['STRADA',
'RPS6',
'TSC2',
'BRAF',
'TSC1',
'VEGFA',
'RRAGB',
'RRAGA',
'PIK3CB',
'RRAGD',
'PIK3CA',
'RRAGC',
'AKT1S1',
'ULK3',
'ULK2',
'ULK1',
'EIF4E2',
'EIF4B',
'PRKAA2',
'CAB39L',
'PIK3R5',
'PIK3R3',
'TNF',
'PIK3R2',
'PRKAA1',
'AKT3',
'AKT1',
'AKT2',
'EIF4E',
'PRKCG',
'PDPK1',
'PRKCB',
'IGF1',
'PRKCA',
'MTOR',
'EIF4E1B',
'PIK3R1',
'RHEB',
'RPS6KB2',
'RPS6KB1',
'DDIT4',
'IRS1',
'CAB39',
'EIF4EBP1',
'PTEN',
'PIK3CD',
'HIF1A',
'INS',
'PIK3CG',
'IKBKB',
'RPTOR',
'STK11',
'RPS6KA6',
'RPS6KA1',
'RPS6KA3',
'MLST8',
'RPS6KA2',
'MAPK3',
'MAPK1',
'RICTOR'],
'Aldosterone-regulated sodium reabsorption Homo sapiens hsa04960': ['PRKCG',
'INSR',
'PDPK1',
'PRKCB',
'ATP1B4',
'IGF1',
'PRKCA',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'SCNN1G',
'PIK3CB',
'PIK3R1',
'PIK3CA',
'FXYD4',
'FXYD2',
'SCNN1B',
'KRAS',
'SGK1',
'IRS1',
'PIK3R5',
'NEDD4L',
'SCNN1A',
'ATP1A4',
'ATP1A3',
'PIK3CD',
'PIK3R3',
'ATP1A2',
'PIK3R2',
'ATP1A1',
'INS',
'NR3C2',
'PIK3CG',
'HSD11B2',
'SLC9A3R2',
'MAPK3',
'MAPK1',
'SFN',
'KCNJ1'],
'Carbohydrate digestion and absorption Homo sapiens hsa04973': ['G6PC',
'MGAM',
'AMY1A',
'AMY1B',
'AMY1C',
'PRKCB',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'G6PC2',
'G6PC3',
'PIK3CB',
'PIK3R1',
'PIK3CA',
'FXYD2',
'HKDC1',
'PLCB2',
'LCT',
'AMY2A',
'AMY2B',
'PIK3R5',
'SLC2A2',
'ATP1A4',
'ATP1A3',
'PIK3CD',
'PIK3R3',
'SLC5A1',
'ATP1A2',
'CACNA1D',
'PIK3R2',
'SLC2A5',
'ATP1A1',
'HK1',
'HK3',
'PIK3CG',
'HK2',
'GNAT3',
'SI',
'AKT3',
'AKT1',
'AKT2',
'TAS1R3',
'TAS1R2',
'SLC37A4'],
'Thyroid hormone signaling pathway Homo sapiens hsa04919': ['MED1',
'SLC16A2',
'MED4',
'BAD',
'DIO1',
'DIO2',
'DIO3',
'ATP1B4',
'TSC2',
'ATP1B3',
'ATP1B2',
'MED13L',
'ATP1B1',
'PLCD1',
'PLCD4',
'TP53',
'RAF1',
'PLCD3',
'ATP1A4',
'ATP1A3',
'ATP1A2',
'ATP1A1',
'SLC9A1',
'FOXO1',
'ACTB',
'NRAS',
'RXRA',
'RXRB',
'CCND1',
'AKT3',
'MYC',
'AKT1',
'PLCE1',
'AKT2',
'RXRG',
'PRKCG',
'CREBBP',
'MAP2K2',
'MAP2K1',
'PRKCB',
'PRKCA',
'SLC16A10',
'ESR1',
'MED27',
'RCAN1',
'MED24',
'RCAN2',
'PIK3R1',
'RHEB',
'MDM2',
'NOTCH3',
'NOTCH4',
'PFKFB2',
'NOTCH1',
'NOTCH2',
'SLC2A1',
'ACTG1',
'GATA4',
'HIF1A',
'MED12L',
'PRKACG',
'MED30',
'PLCG1',
'PLCG2',
'PRKACB',
'PRKACA',
'NCOA2',
'NCOA3',
'NCOA1',
'BMP4',
'KAT2B',
'NCOR1',
'KAT2A',
'SLCO1C1',
'PIK3CB',
'PIK3CA',
'FXYD2',
'MYH6',
'GSK3B',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'MED17',
'MED16',
'MED13',
'MED12',
'MED14',
'CASP9',
'PLCZ1',
'WNT4',
'STAT1',
'PDPK1',
'MTOR',
'PLCB4',
'TBC1D4',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'PFKP',
'SRC',
'HDAC3',
'HDAC1',
'THRB',
'HDAC2',
'THRA',
'CTNNB1',
'ITGB3',
'ATP2A2',
'PIK3CD',
'PIK3CG',
'PLN',
'EP300',
'SIN3A',
'MAPK3',
'HRAS',
'MAPK1',
'ITGAV'],
'Sphingolipid signaling pathway Homo sapiens hsa04071': ['PPP2R1A',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'BAX',
'DEGS2',
'DEGS1',
'TP53',
'NSMAF',
'RAF1',
'RELA',
'ASAH2',
'ROCK1',
'ROCK2',
'SGMS2',
'SGMS1',
'TNF',
'ASAH1',
'NRAS',
'AKT3',
'AKT1',
'S1PR2',
'AKT2',
'ADORA3',
'S1PR1',
'S1PR4',
'S1PR3',
'ADORA1',
'S1PR5',
'MAP3K5',
'CERS4',
'PRKCG',
'CERS5',
'MAP2K2',
'CERS6',
'MAP2K1',
'PRKCE',
'PRKCB',
'PRKCA',
'TRAF2',
'NFKB1',
'ACER2',
'PRKCZ',
'ACER1',
'PIK3R1',
'GNAQ',
'CERS1',
'CERS2',
'CERS3',
'RHOA',
'SPHK2',
'SPHK1',
'PPP2R5C',
'GAB2',
'PPP2R5B',
'PPP2R5E',
'PPP2R5D',
'PPP2R5A',
'TNFRSF1A',
'PIK3CB',
'PIK3CA',
'BCL2',
'MS4A2',
'ABCC1',
'OPRD1',
'TRADD',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'PLD2',
'PLD1',
'SGPL1',
'BDKRB2',
'FCER1A',
'FCER1G',
'CTSD',
'NOS3',
'PDPK1',
'PPP2R3A',
'PPP2R3C',
'PPP2R3B',
'SGPP2',
'PPP2CA',
'SGPP1',
'PLCB4',
'PPP2R2D',
'PPP2R2C',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'PTEN',
'PPP2R2B',
'PIK3CD',
'PPP2R2A',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'PPP2CB',
'MAPK9',
'SPTLC1',
'MAPK8',
'SPTLC2',
'SPTLC3',
'PPP2R1B',
'GNA12',
'SMPD2',
'GNA13',
'SMPD1',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'RAC1',
'FYN',
'RAC2',
'BID'],
'Chagas disease (American trypanosomiasis) Homo sapiens hsa05142': ['TGFB1',
'TGFB3',
'TGFB2',
'PPP2R1A',
'TICAM1',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'FAS',
'RELA',
'ADCY1',
'SERPINE1',
'TNF',
'AKT3',
'AKT1',
'AKT2',
'SMAD3',
'MAP2K4',
'SMAD2',
'NFKB1',
'GNAL',
'MYD88',
'PIK3R1',
'GNAQ',
'TRAF6',
'GNAS',
'FASLG',
'C3',
'IL12B',
'IL12A',
'ACE',
'IL10',
'JUN',
'CFLAR',
'IRAK4',
'TGFBR1',
'TGFBR2',
'TNFRSF1A',
'IL2',
'TLR2',
'IL1B',
'NFKBIA',
'IL6',
'PIK3CB',
'PIK3CA',
'IFNG',
'GNAO1',
'TLR9',
'CD247',
'CALR',
'TLR6',
'TLR4',
'CXCL8',
'CCL3L1',
'CCL3L3',
'PIK3R5',
'PIK3R3',
'CD3G',
'PIK3R2',
'CD3E',
'CD3D',
'CASP8',
'IRAK1',
'BDKRB2',
'FADD',
'IFNGR1',
'IFNGR2',
'CHUK',
'FOS',
'PPP2CA',
'PLCB4',
'PPP2R2D',
'PPP2R2C',
'PLCB2',
'PLCB3',
'PLCB1',
'C1QC',
'C1QB',
'C1QA',
'PPP2R2B',
'PIK3CD',
'PPP2R2A',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'PPP2CB',
'GNA14',
'GNA15',
'IKBKB',
'MAPK9',
'MAPK8',
'PPP2R1B',
'GNA11',
'CCL5',
'MAPK3',
'CCL3',
'MAPK1',
'CCL2',
'IFNB1',
'NOS2',
'IKBKG'],
'AGE-RAGE signaling pathway in diabetic complications Homo sapiens hsa04933': ['TGFB1',
'TGFB3',
'TGFB2',
'VCAM1',
'MAPK13',
'MAPK14',
'COL1A2',
'MAPK11',
'COL1A1',
'MAPK12',
'MAPK10',
'AGTR1',
'BAX',
'PLCD1',
'PLCD4',
'PLCD3',
'FIGF',
'RELA',
'SERPINE1',
'TNF',
'FOXO1',
'NRAS',
'CCND1',
'AKT3',
'AKT1',
'PLCE1',
'AKT2',
'SMAD3',
'STAT5B',
'EGR1',
'SMAD2',
'SMAD4',
'PRKCD',
'PRKCE',
'CYBB',
'PRKCB',
'PRKCA',
'SELE',
'NFKB1',
'DIAPH1',
'PRKCZ',
'PIK3R1',
'NOX1',
'NOX3',
'AGER',
'ICAM1',
'PIM1',
'PLCG1',
'PLCG2',
'STAT5A',
'EDN1',
'JUN',
'MMP2',
'VEGFC',
'FN1',
'NFATC1',
'TGFBR1',
'TGFBR2',
'VEGFA',
'VEGFB',
'IL1A',
'IL1B',
'IL6',
'COL3A1',
'PIK3CB',
'PIK3CA',
'CDK4',
'BCL2',
'CXCL8',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'CASP3',
'NOS3',
'STAT1',
'STAT3',
'F3',
'CDC42',
'PLCB4',
'COL4A1',
'COL4A3',
'COL4A2',
'COL4A5',
'COL4A4',
'COL4A6',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'CDKN1B',
'PIK3CD',
'PIK3CG',
'THBD',
'MAPK9',
'MAPK8',
'MAPK3',
'HRAS',
'MAPK1',
'RAC1',
'CCL2',
'JAK2'],
'Amoebiasis Homo sapiens hsa05146': ['TGFB1',
'TGFB3',
'TGFB2',
'IL1R1',
'ACTN4',
'IL1R2',
'ACTN3',
'ACTN2',
'ACTN1',
'COL1A2',
'COL1A1',
'RELA',
'CSF2',
'ADCY1',
'TNF',
'MUC2',
'PRKCG',
'PRKCB',
'PRKCA',
'NFKB1',
'PTK2',
'GNAL',
'PIK3R1',
'GNAQ',
'GNAS',
'RAB5A',
'RAB5B',
'VCL',
'CD1D',
'PRKACG',
'C9',
'IL12B',
'IL12A',
'PRKACB',
'CD14',
'PRKACA',
'IL10',
'LAMB4',
'LAMB3',
'FN1',
'LAMB2',
'LAMB1',
'TLR2',
'IL1B',
'IL6',
'COL3A1',
'PIK3CB',
'PIK3CA',
'IFNG',
'TLR4',
'RAB7A',
'RAB7B',
'CXCL8',
'RAB5C',
'LAMC1',
'PIK3R5',
'C8A',
'LAMC3',
'PIK3R3',
'LAMC2',
'PIK3R2',
'CXCL1',
'C8B',
'HSPB1',
'C8G',
'LOC102723407',
'CASP3',
'CTSG',
'SERPINB4',
'SERPINB3',
'ARG1',
'SERPINB1',
'ARG2',
'SERPINB9',
'SERPINB6',
'PLCB4',
'COL4A1',
'COL4A3',
'COL4A2',
'COL4A5',
'COL4A4',
'COL4A6',
'PLCB2',
'PLCB3',
'PLCB1',
'ITGB2',
'SERPINB13',
'LAMA3',
'LAMA2',
'LAMA5',
'SERPINB10',
'LAMA4',
'LAMA1',
'PIK3CD',
'ITGAM',
'PIK3CG',
'GNA14',
'GNA15',
'GNA11',
'NOS2'],
'Natural killer cell mediated cytotoxicity Homo sapiens hsa04650': ['KLRC3',
'TYROBP',
'FAS',
'KLRD1',
'ULBP1',
'ULBP3',
'ULBP2',
'PTPN6',
'RAF1',
'CSF2',
'TNF',
'ARAF',
'NRAS',
'PAK1',
'SH3BP2',
'KIR2DL5A',
'MICA',
'MICB',
'PRKCG',
'IFNA13',
'MAP2K2',
'IFNA14',
'KIR2DS1',
'KIR2DS2',
'IFNA16',
'KIR2DS3',
'MAP2K1',
'IFNA17',
'SH2D1A',
'KIR2DS4',
'SH2D1B',
'KIR2DS5',
'HLA-C',
'TNFRSF10D',
'TNFRSF10C',
'HLA-A',
'PRKCB',
'TNFRSF10B',
'HLA-B',
'PRKCA',
'TNFRSF10A',
'HLA-G',
'HLA-E',
'RAET1E',
'RAET1G',
'PIK3R1',
'RAET1L',
'GRB2',
'IFNA10',
'IFNAR1',
'IFNAR2',
'PRF1',
'FASLG',
'ICAM1',
'ICAM2',
'PPP3R1',
'KLRK1',
'PPP3R2',
'KLRC1',
'PLCG1',
'KLRC2',
'PLCG2',
'TNFSF10',
'IFNA21',
'PTPN11',
'NFATC2',
'BRAF',
'NFATC1',
'VAV1',
'VAV2',
'VAV3',
'NCR2',
'NCR3',
'PIK3CB',
'PIK3CA',
'NCR1',
'IFNG',
'HCST',
'LCP2',
'CD247',
'SOS2',
'CD244',
'LAT',
'SOS1',
'SHC3',
'SHC4',
'SHC1',
'SHC2',
'PIK3R5',
'KIR2DL1',
'PIK3R3',
'KIR2DL2',
'PIK3R2',
'KIR2DL3',
'KIR2DL4',
'LOC102723407',
'KLRC4-KLRK1',
'PPP3CA',
'FCGR3A',
'PPP3CB',
'FCGR3B',
'PPP3CC',
'CASP3',
'FCER1G',
'IFNGR1',
'SYK',
'IFNGR2',
'GZMB',
'KIR3DL1',
'KIR3DL2',
'LCK',
'ZAP70',
'CD48',
'KRAS',
'ITGB2',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'PIK3CD',
'ITGAL',
'PIK3CG',
'PTK2B',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'RAC1',
'IFNB1',
'FYN',
'RAC2',
'BID'],
'Fc gamma R-mediated phagocytosis Homo sapiens hsa04666': ['GSN',
'LYN',
'LIMK1',
'SPHK2',
'LIMK2',
'SPHK1',
'GAB2',
'VAV1',
'VAV2',
'DNM2',
'VAV3',
'PTPRC',
'FCGR2A',
'FCGR2B',
'MARCKS',
'PIK3CB',
'PIK3CA',
'NCF1',
'DOCK2',
'LAT',
'RAF1',
'ARPC1A',
'ARPC1B',
'PIK3R5',
'ARPC5L',
'PIK3R3',
'ASAP2',
'PIK3R2',
'ASAP3',
'INPPL1',
'PLD2',
'PLD1',
'LOC102723407',
'CRKL',
'FCGR3A',
'SCIN',
'PAK1',
'ASAP1',
'AKT3',
'CFL2',
'CFL1',
'AKT1',
'AKT2',
'WASF1',
'WASF2',
'WASF3',
'PRKCG',
'MARCKSL1',
'PRKCD',
'PLA2G4E',
'SYK',
'MAP2K1',
'PLA2G4F',
'PRKCE',
'MYO10',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'ARPC5',
'PRKCA',
'HCK',
'CDC42',
'VASP',
'ARPC3',
'PIK3R1',
'RPS6KB2',
'PPAP2A',
'ARPC4',
'RPS6KB1',
'BIN1',
'PPAP2C',
'ARPC2',
'PPAP2B',
'CRK',
'AMPH',
'ARF6',
'WAS',
'WASL',
'PIK3CD',
'PLA2G6',
'PIK3CG',
'INPP5D',
'FCGR1A',
'MAPK3',
'PIP5K1A',
'PIP5K1B',
'MAPK1',
'PLCG1',
'RAC1',
'PIP5K1C',
'PLCG2',
'RAC2'],
'Choline metabolism in cancer Homo sapiens hsa05231': ['PDGFRB',
'EGF',
'PDGFRA',
'TSC2',
'TSC1',
'SLC5A7',
'MAPK10',
'RAF1',
'DGKH',
'DGKG',
'DGKE',
'DGKD',
'DGKB',
'DGKA',
'EGFR',
'NRAS',
'AKT3',
'AKT1',
'AKT2',
'PCYT1A',
'PRKCG',
'MAP2K2',
'PCYT1B',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'DGKZ',
'PIK3R1',
'RHEB',
'DGKQ',
'GRB2',
'DGKK',
'DGKI',
'SLC22A5',
'SLC22A4',
'SLC22A1',
'SLC22A3',
'EIF4EBP1',
'SLC22A2',
'PDGFC',
'PDGFB',
'PDGFA',
'HIF1A',
'PDGFD',
'PIP5K1A',
'PIP5K1B',
'PLCG1',
'PIP5K1C',
'JUN',
'LYPLA1',
'CHKB',
'CHKA',
'GPCPD1',
'SP1',
'PIK3CB',
'PIK3CA',
'CHPT1',
'SOS2',
'SOS1',
'SLC44A4',
'SLC44A5',
'SLC44A2',
'SLC44A3',
'SLC44A1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'PLD2',
'PLD1',
'WASF1',
'WASF2',
'RALGDS',
'WASF3',
'PDPK1',
'FOS',
'MTOR',
'RPS6KB2',
'PPAP2A',
'RPS6KB1',
'PPAP2C',
'PPAP2B',
'JMJD7-PLA2G4B',
'KRAS',
'WAS',
'WASL',
'PIK3CD',
'PIK3CG',
'MAPK9',
'MAPK8',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'RAC1',
'RAC2'],
'Phospholipase D signaling pathway Homo sapiens hsa04072': ['PDGFRB',
'EGF',
'PDGFRA',
'TSC2',
'TSC1',
'LPAR6',
'AGTR1',
'RAF1',
'DGKH',
'DGKG',
'RALB',
'DGKE',
'ADCY1',
'DGKD',
'RALA',
'DGKB',
'DGKA',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ADCY9',
'ADCY8',
'EGFR',
'ADCY7',
'ADCY6',
'NRAS',
'AKT3',
'AKT1',
'AKT2',
'INSR',
'MAP2K2',
'F2R',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'AVPR1A',
'PRKCA',
'AVPR1B',
'DGKZ',
'PIK3R1',
'RHEB',
'DGKQ',
'GNAS',
'GRB2',
'DGKK',
'DGKI',
'PTGFR',
'PDGFC',
'LPAR2',
'PDGFB',
'LPAR3',
'PDGFA',
'LPAR4',
'LPAR5',
'LPAR1',
'PDGFD',
'PIP5K1A',
'PIP5K1B',
'PLCG1',
'PIP5K1C',
'PLCG2',
'RHOA',
'AVPR2',
'SPHK1',
'GAB2',
'GAB1',
'PTPN11',
'DNM1',
'DNM2',
'DNM3',
'MRAS',
'KITLG',
'PIK3CB',
'PIK3CA',
'RAPGEF3',
'SOS2',
'MS4A2',
'RAPGEF4',
'SOS1',
'CXCL8',
'SHC3',
'SHC4',
'SHC1',
'SHC2',
'ARF1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'AGPAT1',
'AGPAT2',
'PLD2',
'AGPAT3',
'PLD1',
'AGPAT4',
'AGPAT5',
'LOC102723407',
'RRAS2',
'RRAS',
'FCER1A',
'FCER1G',
'RALGDS',
'SYK',
'MTOR',
'PLCB4',
'KIT',
'PPAP2A',
'PPAP2C',
'PPAP2B',
'JMJD7-PLA2G4B',
'AVP',
'KRAS',
'PLCB2',
'PLCB3',
'ARF6',
'PLCB1',
'PIK3CD',
'INS',
'GRM2',
'PIK3CG',
'GRM1',
'CYTH4',
'GRM4',
'CYTH3',
'GRM3',
'GRM6',
'GRM5',
'CXCR2',
'GRM8',
'CXCR1',
'GRM7',
'GNA12',
'GNA13',
'PTK2B',
'MAPK3',
'HRAS',
'MAPK1',
'FYN',
'CYTH2',
'CYTH1'],
'Central carbon metabolism in cancer Homo sapiens hsa05230': ['PDGFRB',
'PDGFRA',
'PDHA2',
'G6PD',
'PDHA1',
'SIRT6',
'SIRT3',
'GCK',
'SLC7A5',
'PIK3CB',
'SCO2',
'PIK3CA',
'TP53',
'RAF1',
'RET',
'GLS2',
'PIK3R5',
'PDHB',
'PIK3R3',
'SLC1A5',
'PIK3R2',
'GLS',
'HK1',
'EGFR',
'HK3',
'HK2',
'NRAS',
'LDHA',
'AKT3',
'ERBB2',
'MYC',
'AKT1',
'AKT2',
'SLC16A3',
'IDH1',
'NTRK3',
'MAP2K2',
'NTRK1',
'MAP2K1',
'PGAM1',
'PGAM2',
'MTOR',
'PKM',
'C12ORF5',
'PFKM',
'PFKL',
'PIK3R1',
'KIT',
'HKDC1',
'FGFR1',
'PGAM4',
'MET',
'KRAS',
'FGFR3',
'FGFR2',
'PFKP',
'FLT3',
'SLC2A1',
'SLC2A2',
'PTEN',
'PIK3CD',
'HIF1A',
'PIK3CG',
'MAPK3',
'HRAS',
'MAPK1',
'PDK1'],
'HIF-1 signaling pathway Homo sapiens hsa04066': ['EGF',
'RPS6',
'RBX1',
'TEK',
'RELA',
'EPO',
'SERPINE1',
'PDHB',
'EGFR',
'AKT3',
'AKT1',
'AKT2',
'TCEB2',
'TCEB1',
'PRKCG',
'INSR',
'CREBBP',
'MAP2K2',
'MAP2K1',
'CYBB',
'PRKCB',
'IGF1',
'PRKCA',
'NFKB1',
'EIF4E1B',
'PIK3R1',
'NOX1',
'NOX3',
'PFKFB3',
'TFRC',
'SLC2A1',
'EIF4EBP1',
'CUL2',
'ENO1',
'ENO2',
'HIF1A',
'ENO3',
'IGF1R',
'NPPA',
'HMOX1',
'PLCG1',
'PLCG2',
'IL6R',
'PDK1',
'EDN1',
'ANGPT4',
'PDHA2',
'ANGPT2',
'PDHA1',
'ANGPT1',
'VEGFA',
'TF',
'IL6',
'PIK3CB',
'PIK3CA',
'IFNG',
'BCL2',
'EIF4E2',
'ALDOA',
'TLR4',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'HK1',
'HK3',
'HK2',
'LDHA',
'MKNK1',
'MKNK2',
'ERBB2',
'PGK1',
'TIMP1',
'EIF4E',
'EGLN2',
'EGLN1',
'EGLN3',
'NOS3',
'IFNGR1',
'IFNGR2',
'STAT3',
'ARNT',
'MTOR',
'PFKL',
'LTBR',
'RPS6KB2',
'RPS6KB1',
'HKDC1',
'GAPDH',
'CAMK2D',
'FLT1',
'CDKN1B',
'CDKN1A',
'CAMK2A',
'CAMK2B',
'PIK3CD',
'INS',
'PIK3CG',
'EP300',
'MAPK3',
'VHL',
'MAPK1',
'NOS2',
'CAMK2G'],
'Renal cell carcinoma Homo sapiens hsa05211': ['TGFB1',
'TGFB3',
'TGFB2',
'JUN',
'GAB1',
'PTPN11',
'BRAF',
'VEGFA',
'RBX1',
'PIK3CB',
'PIK3CA',
'RAPGEF1',
'SOS2',
'SOS1',
'RAF1',
'EPAS1',
'PIK3R5',
'PIK3R3',
'TGFA',
'PIK3R2',
'ARAF',
'CRKL',
'NRAS',
'RAP1A',
'PAK2',
'RAP1B',
'PAK1',
'AKT3',
'AKT1',
'AKT2',
'PAK7',
'TCEB2',
'TCEB1',
'PAK4',
'PAK3',
'PAK6',
'EGLN2',
'ARNT2',
'EGLN1',
'CREBBP',
'MAP2K2',
'EGLN3',
'MAP2K1',
'HGF',
'ARNT',
'CDC42',
'PIK3R1',
'CRK',
'MET',
'GRB2',
'KRAS',
'FH',
'SLC2A1',
'CUL2',
'PDGFB',
'PIK3CD',
'HIF1A',
'ETS1',
'PIK3CG',
'FLCN',
'EP300',
'MAPK3',
'VHL',
'HRAS',
'MAPK1',
'RAC1'],
'ErbB signaling pathway Homo sapiens hsa04012': ['EGF',
'JUN',
'BAD',
'GAB1',
'NRG1',
'NRG2',
'BRAF',
'NRG3',
'EREG',
'MAPK10',
'PIK3CB',
'NRG4',
'PIK3CA',
'SOS2',
'SOS1',
'RAF1',
'SHC3',
'GSK3B',
'SHC4',
'SHC1',
'SHC2',
'PIK3R5',
'PIK3R3',
'TGFA',
'CBLC',
'PIK3R2',
'ARAF',
'CBLB',
'AREG',
'EGFR',
'CRKL',
'NRAS',
'PAK2',
'PAK1',
'ERBB4',
'AKT3',
'ERBB2',
'MYC',
'ERBB3',
'AKT1',
'AKT2',
'PAK7',
'PAK4',
'PAK3',
'PAK6',
'STAT5B',
'MAP2K4',
'PRKCG',
'MAP2K2',
'MAP2K1',
'PRKCB',
'PRKCA',
'MTOR',
'PTK2',
'BTC',
'PIK3R1',
'RPS6KB2',
'RPS6KB1',
'CRK',
'GRB2',
'KRAS',
'HBEGF',
'CAMK2D',
'SRC',
'CDKN1B',
'CDKN1A',
'CAMK2A',
'CAMK2B',
'EIF4EBP1',
'PIK3CD',
'ELK1',
'CBL',
'PIK3CG',
'MAPK9',
'MAPK8',
'MAPK3',
'ABL2',
'HRAS',
'MAPK1',
'PLCG1',
'PLCG2',
'ABL1',
'CAMK2G',
'NCK1',
'STAT5A',
'MAP2K7',
'NCK2'],
'Acute myeloid leukemia Homo sapiens hsa05221': ['BAD',
'JUP',
'ZBTB16',
'RUNX1',
'BRAF',
'PML',
'PIK3CB',
'PIK3CA',
'RARA',
'SOS2',
'SOS1',
'RAF1',
'LEF1',
'RELA',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ARAF',
'NRAS',
'CCND1',
'AKT3',
'MYC',
'AKT1',
'AKT2',
'RUNX1T1',
'STAT5B',
'MAP2K2',
'TCF7L2',
'TCF7L1',
'MAP2K1',
'CHUK',
'STAT3',
'NFKB1',
'MTOR',
'CCNA1',
'PIK3R1',
'KIT',
'RPS6KB2',
'RPS6KB1',
'TCF7',
'GRB2',
'KRAS',
'PPARD',
'CEBPA',
'SPI1',
'FLT3',
'EIF4EBP1',
'PIK3CD',
'PIK3CG',
'IKBKB',
'PIM2',
'MAPK3',
'PIM1',
'HRAS',
'MAPK1',
'IKBKG',
'STAT5A'],
'Endometrial cancer Homo sapiens hsa05213': ['EGF',
'BAD',
'AXIN2',
'AXIN1',
'BRAF',
'APC',
'PIK3CB',
'PIK3CA',
'SOS2',
'TP53',
'SOS1',
'RAF1',
'LEF1',
'GSK3B',
'ILK',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ARAF',
'EGFR',
'FOXO3',
'NRAS',
'CASP9',
'CCND1',
'AKT3',
'ERBB2',
'CDH1',
'MYC',
'AKT1',
'AKT2',
'MAP2K2',
'TCF7L2',
'MLH1',
'APC2',
'TCF7L1',
'MAP2K1',
'PDPK1',
'PIK3R1',
'TCF7',
'GRB2',
'KRAS',
'CTNNB1',
'PTEN',
'PIK3CD',
'ELK1',
'PIK3CG',
'MAPK3',
'CTNNA2',
'CTNNA1',
'HRAS',
'MAPK1',
'CTNNA3'],
'Colorectal cancer Homo sapiens hsa05210': ['TGFB1',
'RHOA',
'TGFB3',
'TGFB2',
'JUN',
'BAD',
'AXIN2',
'AXIN1',
'BRAF',
'MSH2',
'TGFBR1',
'TGFBR2',
'APC',
'MAPK10',
'PIK3CB',
'MSH3',
'PIK3CA',
'MSH6',
'BCL2',
'BAX',
'CYCS',
'TP53',
'RAF1',
'LEF1',
'GSK3B',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ARAF',
'CASP9',
'CCND1',
'AKT3',
'MYC',
'AKT1',
'AKT2',
'CASP3',
'RALGDS',
'SMAD3',
'SMAD2',
'DCC',
'TCF7L2',
'SMAD4',
'MLH1',
'APC2',
'TCF7L1',
'MAP2K1',
'FOS',
'PIK3R1',
'BIRC5',
'TCF7',
'KRAS',
'CTNNB1',
'PIK3CD',
'PIK3CG',
'MAPK9',
'MAPK8',
'MAPK3',
'RAC3',
'MAPK1',
'RAC1',
'RAC2',
'APPL1'],
'Pancreatic cancer Homo sapiens hsa05212': ['TGFB1',
'RALBP1',
'TGFB3',
'EGF',
'TGFB2',
'BAD',
'BRAF',
'TGFBR1',
'TGFBR2',
'VEGFA',
'MAPK10',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'ARHGEF6',
'TP53',
'RAF1',
'RB1',
'RELA',
'RALB',
'RALA',
'PIK3R5',
'PIK3R3',
'TGFA',
'PIK3R2',
'ARAF',
'BRCA2',
'EGFR',
'PLD1',
'CASP9',
'CCND1',
'AKT3',
'ERBB2',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'RALGDS',
'SMAD3',
'SMAD2',
'SMAD4',
'CDKN2A',
'STAT1',
'MAP2K1',
'CHUK',
'STAT3',
'NFKB1',
'CDC42',
'RAD51',
'PIK3R1',
'BCL2L1',
'KRAS',
'PIK3CD',
'PIK3CG',
'IKBKB',
'MAPK9',
'MAPK8',
'MAPK3',
'RAC3',
'MAPK1',
'RAC1',
'RAC2',
'IKBKG',
'JAK1'],
'Chronic myeloid leukemia Homo sapiens hsa05220': ['TGFB1',
'TGFB3',
'TGFB2',
'BAD',
'GAB2',
'RUNX1',
'PTPN11',
'BRAF',
'TGFBR1',
'TGFBR2',
'NFKBIA',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'SOS2',
'TP53',
'SOS1',
'RAF1',
'RB1',
'RELA',
'SHC3',
'SHC4',
'SHC1',
'SHC2',
'PIK3R5',
'PIK3R3',
'CBLC',
'PIK3R2',
'ARAF',
'CBLB',
'CRKL',
'NRAS',
'MECOM',
'CCND1',
'AKT3',
'MYC',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'SMAD3',
'STAT5B',
'MAP2K2',
'SMAD4',
'CDKN2A',
'MAP2K1',
'CHUK',
'NFKB1',
'BCR',
'PIK3R1',
'BCL2L1',
'CRK',
'GRB2',
'KRAS',
'MDM2',
'CDKN1B',
'HDAC1',
'CTBP2',
'HDAC2',
'CDKN1A',
'CTBP1',
'PIK3CD',
'CBL',
'PIK3CG',
'IKBKB',
'MAPK3',
'HRAS',
'MAPK1',
'ABL1',
'IKBKG',
'STAT5A'],
'Prostate cancer Homo sapiens hsa05215': ['PDGFRB',
'EGF',
'PDGFRA',
'HSP90AA1',
'INSRR',
'BAD',
'SRD5A2',
'BRAF',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'CDK2',
'BCL2',
'SOS2',
'TP53',
'SOS1',
'RAF1',
'LEF1',
'RB1',
'RELA',
'GSK3B',
'PIK3R5',
'PIK3R3',
'TGFA',
'PIK3R2',
'ARAF',
'KLK3',
'EGFR',
'HSP90B1',
'FOXO1',
'CREB3L1',
'NRAS',
'CASP9',
'CREB3L4',
'CCND1',
'CREB3L2',
'AKT3',
'ERBB2',
'CREB3L3',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'CREBBP',
'MAP2K2',
'TCF7L2',
'TCF7L1',
'MAP2K1',
'CHUK',
'PDPK1',
'IGF1',
'NFKB1',
'MTOR',
'CREB3',
'AR',
'CREB1',
'PIK3R1',
'CCNE2',
'CCNE1',
'FGFR1',
'TCF7',
'GRB2',
'KRAS',
'ATF4',
'CREB5',
'MDM2',
'FGFR2',
'CDKN1B',
'HSP90AB1',
'CDKN1A',
'CTNNB1',
'GSTP1',
'PDGFC',
'PTEN',
'PDGFB',
'PIK3CD',
'PDGFA',
'INS',
'IGF1R',
'PIK3CG',
'IKBKB',
'EP300',
'PDGFD',
'MAPK3',
'NKX3-1',
'HRAS',
'MAPK1',
'IKBKG'],
'Melanoma Homo sapiens hsa05218': ['PDGFRB',
'EGF',
'PDGFRA',
'BAD',
'MITF',
'BRAF',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'TP53',
'RAF1',
'RB1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'ARAF',
'EGFR',
'NRAS',
'CCND1',
'AKT3',
'CDH1',
'E2F1',
'AKT1',
'E2F2',
'FGF21',
'AKT2',
'E2F3',
'FGF20',
'FGF23',
'FGF22',
'MAP2K2',
'CDKN2A',
'MAP2K1',
'HGF',
'IGF1',
'FGF18',
'FGF17',
'FGF16',
'PIK3R1',
'FGF19',
'FGF10',
'FGFR1',
'MET',
'KRAS',
'FGF14',
'FGF13',
'FGF12',
'MDM2',
'FGF11',
'CDKN1A',
'PDGFC',
'PTEN',
'PDGFB',
'PIK3CD',
'PDGFA',
'FGF1',
'FGF2',
'FGF3',
'FGF4',
'IGF1R',
'PIK3CG',
'FGF5',
'FGF6',
'FGF7',
'FGF8',
'FGF9',
'PDGFD',
'MAPK3',
'HRAS',
'MAPK1'],
'Glioma Homo sapiens hsa05214': ['PDGFRB',
'EGF',
'PDGFRA',
'BRAF',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'CALM2',
'SOS2',
'CALM3',
'TP53',
'CALM1',
'SOS1',
'RAF1',
'RB1',
'SHC3',
'SHC4',
'CALML6',
'SHC1',
'SHC2',
'PIK3R5',
'CALML3',
'PIK3R3',
'TGFA',
'CALML5',
'PIK3R2',
'ARAF',
'EGFR',
'NRAS',
'CCND1',
'AKT3',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'PRKCG',
'MAP2K2',
'CDKN2A',
'MAP2K1',
'PRKCB',
'IGF1',
'PRKCA',
'MTOR',
'PIK3R1',
'GRB2',
'KRAS',
'MDM2',
'CAMK2D',
'CDKN1A',
'CAMK2A',
'CAMK2B',
'PTEN',
'PDGFB',
'PIK3CD',
'PDGFA',
'IGF1R',
'PIK3CG',
'MAPK3',
'HRAS',
'MAPK1',
'PLCG1',
'PLCG2',
'CAMK2G'],
'Non-small cell lung cancer Homo sapiens hsa05223': ['EGF',
'BAD',
'BRAF',
'EML4',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'RARB',
'SOS2',
'TP53',
'SOS1',
'RAF1',
'ALK',
'RB1',
'PIK3R5',
'PIK3R3',
'TGFA',
'PIK3R2',
'ARAF',
'FHIT',
'EGFR',
'FOXO3',
'STK4',
'NRAS',
'RXRA',
'RXRB',
'CASP9',
'CCND1',
'AKT3',
'ERBB2',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'RXRG',
'PRKCG',
'MAP2K2',
'CDKN2A',
'MAP2K1',
'PDPK1',
'PRKCB',
'PRKCA',
'PIK3R1',
'GRB2',
'KRAS',
'PIK3CD',
'PIK3CG',
'RASSF1',
'RASSF5',
'MAPK3',
'HRAS',
'MAPK1',
'PLCG1',
'PLCG2'],
'VEGF signaling pathway Homo sapiens hsa04370': ['BAD',
'SPHK2',
'SPHK1',
'NFATC2',
'VEGFA',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'PIK3CB',
'PIK3CA',
'MAPKAPK2',
'MAPKAPK3',
'RAF1',
'SH2D2A',
'SHC2',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'HSPB1',
'PPP3CA',
'NRAS',
'PPP3CB',
'PPP3CC',
'CASP9',
'AKT3',
'AKT1',
'AKT2',
'KDR',
'PRKCG',
'MAP2K2',
'NOS3',
'PLA2G4E',
'MAP2K1',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'PTK2',
'CDC42',
'PIK3R1',
'JMJD7-PLA2G4B',
'KRAS',
'SRC',
'PXN',
'PIK3CD',
'PTGS2',
'PIK3CG',
'PPP3R1',
'PPP3R2',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'PLCG1',
'RAC1',
'PLCG2',
'RAC2'],
'Fc epsilon RI signaling pathway Homo sapiens hsa04664': ['LYN',
'IL13',
'GAB2',
'VAV1',
'VAV2',
'IL3',
'MAPK13',
'VAV3',
'MAPK14',
'IL5',
'MAPK11',
'IL4',
'MAPK12',
'MAPK10',
'PIK3CB',
'PIK3CA',
'LCP2',
'SOS2',
'MS4A2',
'LAT',
'SOS1',
'RAF1',
'CSF2',
'PIK3R5',
'PIK3R3',
'TNF',
'PIK3R2',
'LOC102723407',
'NRAS',
'AKT3',
'AKT1',
'AKT2',
'FCER1A',
'FCER1G',
'MAP2K4',
'MAP2K2',
'MAP2K3',
'PLA2G4E',
'SYK',
'MAP2K1',
'PLA2G4F',
'PDPK1',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCA',
'PIK3R1',
'JMJD7-PLA2G4B',
'BTK',
'GRB2',
'KRAS',
'PIK3CD',
'PIK3CG',
'INPP5D',
'MAPK9',
'MAPK8',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'PLCG1',
'RAC1',
'FYN',
'PLCG2',
'RAC2',
'MAP2K6',
'MAP2K7'],
'B cell receptor signaling pathway Homo sapiens hsa04662': ['LYN',
'JUN',
'CD72',
'NFATC3',
'NFATC2',
'LILRB3',
'NFATC1',
'VAV1',
'VAV2',
'VAV3',
'NFKBIB',
'NFKBIA',
'FCGR2B',
'PIK3CB',
'PIK3CA',
'SOS2',
'PTPN6',
'NFKBIE',
'CD22',
'SOS1',
'RAF1',
'RELA',
'GSK3B',
'IFITM1',
'CD81',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'INPPL1',
'LOC102723407',
'PPP3CA',
'NRAS',
'PPP3CB',
'PPP3CC',
'AKT3',
'AKT1',
'BLNK',
'AKT2',
'CARD11',
'MAP2K2',
'CR2',
'SYK',
'MAP2K1',
'CHUK',
'FOS',
'PRKCB',
'NFKB1',
'PIK3R1',
'BTK',
'GRB2',
'KRAS',
'PIK3AP1',
'BCL10',
'PIK3CD',
'RASGRP3',
'DAPP1',
'MALT1',
'PIK3CG',
'CD79B',
'PPP3R1',
'IKBKB',
'INPP5D',
'CD79A',
'PPP3R2',
'CD19',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'RAC1',
'PLCG2',
'RAC2',
'IKBKG'],
'T cell receptor signaling pathway Homo sapiens hsa04660': ['MAPK13',
'MAPK14',
'TEC',
'MAPK11',
'MAPK12',
'CD4',
'PDCD1',
'PTPN6',
'RAF1',
'RELA',
'CSF2',
'TNF',
'CBLC',
'CBLB',
'NRAS',
'PAK2',
'PAK1',
'AKT3',
'AKT1',
'GRAP2',
'AKT2',
'PAK7',
'MAP3K7',
'PAK4',
'MAP3K8',
'PAK3',
'PAK6',
'CARD11',
'MAP2K2',
'MAP2K1',
'NFKB1',
'DLG1',
'PIK3R1',
'CD8B',
'CD8A',
'PRKCQ',
'GRB2',
'MAP3K14',
'BCL10',
'PPP3R1',
'RASGRP1',
'PPP3R2',
'PLCG1',
'MAP2K7',
'RHOA',
'IL10',
'JUN',
'NFATC3',
'NFATC2',
'NFATC1',
'VAV1',
'VAV2',
'VAV3',
'IL2',
'IL5',
'NFKBIB',
'IL4',
'NFKBIA',
'PTPRC',
'PIK3CB',
'PIK3CA',
'CDK4',
'IFNG',
'CD28',
'LCP2',
'CD247',
'SOS2',
'NFKBIE',
'ITK',
'LAT',
'SOS1',
'GSK3B',
'PIK3R5',
'PIK3R3',
'CD3G',
'PIK3R2',
'CD3E',
'CD3D',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'CTLA4',
'ICOS',
'CHUK',
'PDPK1',
'FOS',
'CDC42',
'LCK',
'ZAP70',
'KRAS',
'CD40LG',
'PIK3CD',
'CBL',
'MALT1',
'PIK3CG',
'IKBKB',
'MAPK9',
'MAPK3',
'HRAS',
'MAPK1',
'FYN',
'IKBKG',
'NCK1',
'NCK2'],
'Neurotrophin signaling pathway Homo sapiens hsa04722': ['MAP3K3',
'MAP3K1',
'BAD',
'MATK',
'FRS2',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'MAPKAPK2',
'BAX',
'CALM2',
'CALM3',
'TP53',
'CALM1',
'RAF1',
'RELA',
'ZNF274',
'CALML6',
'PRDM4',
'CALML3',
'CALML5',
'FOXO3',
'CRKL',
'NRAS',
'NTF3',
'AKT3',
'NTF4',
'AKT1',
'SH2B1',
'AKT2',
'MAP3K5',
'SH2B3',
'SH2B2',
'NGFR',
'MAP2K5',
'MAP2K2',
'PRKCD',
'MAP2K1',
'NFKB1',
'TP73',
'PIK3R1',
'TRAF6',
'GRB2',
'ATF4',
'IRS1',
'MAGED1',
'PSEN1',
'FASLG',
'PSEN2',
'PLCG1',
'PLCG2',
'ABL1',
'MAP2K7',
'RHOA',
'JUN',
'BDNF',
'GAB1',
'PTPN11',
'IRAK4',
'BRAF',
'NFKBIB',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'CAMK4',
'BCL2',
'RAPGEF1',
'SOS2',
'NFKBIE',
'SOS1',
'SHC3',
'GSK3B',
'SHC4',
'YWHAE',
'SHC1',
'SHC2',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'RAP1A',
'RAP1B',
'IRAK2',
'IRAK3',
'IRAK1',
'RIPK2',
'NTRK2',
'NTRK3',
'NTRK1',
'SORT1',
'PDPK1',
'KIDINS220',
'NGF',
'CDC42',
'NGFRAP1',
'CRK',
'KRAS',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'PIK3CD',
'ARHGDIG',
'PIK3CG',
'RPS6KA5',
'IKBKB',
'ARHGDIA',
'MAPK9',
'MAPK8',
'RPS6KA6',
'RPS6KA1',
'RPS6KA3',
'ARHGDIB',
'RPS6KA2',
'MAPK3',
'HRAS',
'MAPK1',
'RAC1',
'CAMK2G',
'MAPK7'],
'Prolactin signaling pathway Homo sapiens hsa04917': ['PRLR',
'MAPK13',
'MAPK14',
'GCK',
'MAPK11',
'IRF1',
'MAPK12',
'MAPK10',
'TH',
'PIK3CB',
'PIK3CA',
'ELF5',
'SOS2',
'SOS1',
'RAF1',
'GALT',
'RELA',
'SHC3',
'GSK3B',
'SHC4',
'SHC1',
'TNFRSF11A',
'SHC2',
'PIK3R5',
'PRL',
'PIK3R3',
'PIK3R2',
'CSN2',
'FOXO3',
'SOCS3',
'NRAS',
'SOCS4',
'SOCS1',
'SOCS2',
'CCND2',
'CCND1',
'AKT3',
'AKT1',
'AKT2',
'SOCS7',
'SOCS5',
'SOCS6',
'STAT5B',
'LHCGR',
'MAP2K2',
'STAT1',
'MAP2K1',
'CISH',
'STAT3',
'FOS',
'ESR1',
'NFKB1',
'ESR2',
'PIK3R1',
'GRB2',
'KRAS',
'SRC',
'LHB',
'SLC2A2',
'PIK3CD',
'INS',
'PIK3CG',
'CYP17A1',
'MAPK9',
'MAPK8',
'MAPK3',
'TNFSF11',
'HRAS',
'MAPK1',
'CGA',
'JAK2',
'STAT5A'],
'FoxO signaling pathway Homo sapiens hsa04068': ['TGFB1',
'G6PC',
'TGFB3',
'EGF',
'USP7',
'TGFB2',
'HOMER2',
'HOMER3',
'HOMER1',
'PRKAB1',
'PRKAB2',
'MAPK13',
'MAPK14',
'ATG12',
'MAPK11',
'MAPK12',
'MAPK10',
'C8ORF44-SGK3',
'RAF1',
'PRKAA2',
'FOXG1',
'FOXO6',
'ARAF',
'FOXO4',
'EGFR',
'PRKAA1',
'FOXO3',
'FOXO1',
'NRAS',
'BCL2L11',
'CCND2',
'CCND1',
'AKT3',
'AKT1',
'AKT2',
'S1PR1',
'S1PR4',
'SMAD3',
'SMAD2',
'INSR',
'PLK4',
'CREBBP',
'MAP2K2',
'GABARAPL2',
'SMAD4',
'GABARAPL1',
'PLK1',
'MAP2K1',
'GADD45B',
'PLK3',
'GADD45A',
'PLK2',
'GADD45G',
'CSNK1E',
'IGF1',
'FBXO32',
'PIK3R1',
'GRB2',
'MDM2',
'IL7R',
'GABARAP',
'IRS1',
'IRS2',
'SLC2A4',
'FASLG',
'IRS4',
'FBXO25',
'NLK',
'IGF1R',
'STK11',
'CCNB3',
'CCNB2',
'CCNB1',
'TNFSF10',
'RAG1',
'RAG2',
'SKP2',
'IL10',
'BRAF',
'SIRT1',
'TGFBR1',
'G6PC2',
'TGFBR2',
'G6PC3',
'RBL2',
'IL6',
'PIK3CB',
'PIK3CA',
'BCL6',
'CCNG2',
'CDK2',
'ATM',
'SGK2',
'SOS2',
'SGK3',
'SGK1',
'SOS1',
'PIK3R5',
'AGAP2',
'PIK3R3',
'PIK3R2',
'STK4',
'PCK2',
'PCK1',
'CDKN2D',
'CHUK',
'CDKN2B',
'PDPK1',
'STAT3',
'PRMT1',
'KLF2',
'SOD2',
'CAT',
'KRAS',
'CDKN1B',
'CDKN1A',
'SETD7',
'PRKAG2',
'PTEN',
'PRKAG3',
'PIK3CD',
'PRKAG1',
'INS',
'PIK3CG',
'GRM1',
'IKBKB',
'MAPK9',
'MAPK8',
'EP300',
'MAPK3',
'BNIP3',
'HRAS',
'MAPK1'],
'MAPK signaling pathway Homo sapiens hsa04010': ['EGF',
'IL1R1',
'IL1R2',
'HSPA1L',
'CACNA2D2',
'CACNA2D1',
'CACNA2D4',
'CACNA2D3',
'MAPK8IP3',
'MAPK8IP1',
'MAPK13',
'MAPK8IP2',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'HSPA1A',
'TP53',
'HSPA1B',
'ATF2',
'PPP5D1',
'ZAK',
'CRKL',
'AKT3',
'MYC',
'AKT1',
'AKT2',
'PRKCG',
'JUND',
'DAXX',
'PLA2G4E',
'GADD45B',
'PLA2G4F',
'GADD45A',
'PLA2G4C',
'PLA2G4D',
'GADD45G',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'PRKCA',
'GRB2',
'ATF4',
'PDGFB',
'PDGFA',
'ELK1',
'NLK',
'ELK4',
'PRKACG',
'PPP3R1',
'PPP3R2',
'STMN1',
'PRKACB',
'CD14',
'PRKACA',
'DUSP5',
'DUSP6',
'DUSP3',
'DUSP4',
'JUN',
'DUSP1',
'DUSP2',
'NFATC3',
'BRAF',
'NFATC1',
'DUSP9',
'GNG12',
'DUSP7',
'DUSP8',
'IL1A',
'IL1B',
'MRAS',
'ECSIT',
'MAPT',
'RAPGEF2',
'PTPRR',
'PPP3CA',
'PPP3CB',
'RAP1A',
'PPP3CC',
'RAP1B',
'MECOM',
'RRAS2',
'RRAS',
'MAP4K2',
'MAP4K3',
'MAP4K1',
'MEF2C',
'FOS',
'TAOK2',
'TAOK3',
'JMJD7-PLA2G4B',
'TAOK1',
'LAMTOR3',
'IKBKB',
'RAC3',
'HRAS',
'RAC1',
'RAC2',
'IKBKG',
'MAP4K4',
'MAP3K3',
'TGFB1',
'MAP3K4',
'PDGFRB',
'MAP3K1',
'TGFB3',
'PDGFRA',
'MAP3K2',
'TGFB2',
'CDC25B',
'MOS',
'MAPKAPK5',
'FAS',
'MAPKAPK2',
'MAPKAPK3',
'PTPN7',
'PTPN5',
'RAF1',
'RELA',
'TNF',
'EGFR',
'RELB',
'NRAS',
'PAK2',
'PAK1',
'NTF3',
'NTF4',
'FLNA',
'FGF21',
'FLNB',
'FGF20',
'FLNC',
'MAP3K7',
'MAP3K8',
'FGF23',
'MAP3K5',
'MAP3K6',
'FGF22',
'MAP2K4',
'MAP2K5',
'MAP2K2',
'MAP2K3',
'MAP2K1',
'TRAF2',
'NFKB1',
'NFKB2',
'CACNB2',
'FGF18',
'CACNB3',
'FGF17',
'CACNB4',
'FGF16',
'FGF19',
'TRAF6',
'FGF10',
'FGFR1',
'MAP3K11',
'TAB2',
'FGF14',
'MAP3K14',
'TAB1',
'FGF13',
'FGFR4',
'MAP3K12',
'FGF12',
'FGFR3',
'CACNB1',
'MAP3K13',
'FGF11',
'FGFR2',
'MAX',
'CACNA1A',
'CACNA1C',
'CACNA1B',
'CACNA1E',
'FASLG',
'CACNA1D',
'FGF1',
'CACNA1G',
'FGF2',
'RASGRP3',
'CACNA1F',
'FGF3',
'RASGRP2',
'CACNA1I',
'NR4A1',
'FGF4',
'CACNA1H',
'FGF5',
'RASGRP4',
'FGF6',
'FGF7',
'FGF8',
'RASGRP1',
'FGF9',
'CACNA1S',
'MAP2K6',
'MAP2K7',
'HSPA6',
'BDNF',
'HSPA8',
'HSPA2',
'TGFBR1',
'TGFBR2',
'TNFRSF1A',
'PPP5C',
'RASA1',
'RASA2',
'NF1',
'SOS2',
'SOS1',
'RASGRF1',
'RASGRF2',
'DUSP16',
'STK3',
'HSPB1',
'STK4',
'DUSP10',
'MKNK1',
'MKNK2',
'CASP3',
'NTRK2',
'NTRK1',
'CHUK',
'NGF',
'CDC42',
'PPM1A',
'PPM1B',
'DDIT3',
'CRK',
'KRAS',
'SRF',
'ARRB2',
'RPS6KA5',
'CACNG7',
'CACNG8',
'RPS6KA4',
'MAPK9',
'MAPK8',
'RPS6KA6',
'RPS6KA1',
'ARRB1',
'GNA12',
'RPS6KA3',
'RPS6KA2',
'MAPK3',
'CACNG1',
'MAPK1',
'CACNG2',
'CACNG3',
'MAPK7',
'CACNG4',
'CACNG5',
'CACNG6'],
'Ras signaling pathway Homo sapiens hsa04014': ['EGF',
'BAD',
'MAPK10',
'TEK',
'CALM2',
'EPHA2',
'CALM3',
'CALM1',
'RIN1',
'RALB',
'CALML6',
'RALA',
'CALML3',
'CALML5',
'GNG2',
'GNG4',
'GNG3',
'GNG5',
'AKT3',
'GNG8',
'GNG7',
'AKT1',
'PLCE1',
'AKT2',
'KDR',
'SHOC2',
'NGFR',
'PRKCG',
'INSR',
'PLA2G4E',
'PLA2G4F',
'PLA2G4C',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PRKCB',
'IGF1',
'PRKCA',
'PIK3R1',
'GRB2',
'RGL2',
'PLA1A',
'RGL1',
'PDGFC',
'PLA2G3',
'PDGFB',
'PDGFA',
'PLA2G5',
'PLA2G6',
'ELK1',
'PRKACG',
'RASSF1',
'GNG11',
'HTR7',
'GRIN2B',
'GNG10',
'GRIN2A',
'TBK1',
'RASSF5',
'PDGFD',
'PLCG1',
'PLCG2',
'PRKACB',
'PRKACA',
'RHOA',
'BRAP',
'GAB2',
'VEGFC',
'GAB1',
'GNG13',
'GNG12',
'VEGFA',
'VEGFB',
'MRAS',
'KITLG',
'REL',
'EXOC2',
'RAPGEF5',
'RAB5C',
'RASAL1',
'RASAL2',
'RASAL3',
'GNGT2',
'GNGT1',
'RAP1A',
'RAP1B',
'RRAS2',
'RRAS',
'KIT',
'JMJD7-PLA2G4B',
'ARF6',
'IKBKB',
'RAC3',
'HRAS',
'RAC1',
'RAC2',
'IKBKG',
'PDGFRB',
'RALBP1',
'PDGFRA',
'GRIN1',
'RAF1',
'FIGF',
'RELA',
'CSF1',
'FOXO4',
'EFNA5',
'EGFR',
'NRAS',
'PAK2',
'PAK1',
'FGF21',
'FGF20',
'PAK7',
'PAK4',
'PAK3',
'FGF23',
'PAK6',
'FGF22',
'MAP2K2',
'MAP2K1',
'HGF',
'NFKB1',
'PGF',
'EFNA2',
'FGF18',
'EFNA1',
'FGF17',
'EFNA4',
'FGF16',
'EFNA3',
'GNB1',
'GNB3',
'FGF19',
'GNB2',
'FGF10',
'FGFR1',
'BCL2L1',
'GNB5',
'GNB4',
'FGF14',
'RAB5A',
'FGF13',
'FGFR4',
'RAB5B',
'FGF12',
'FGFR3',
'FGF11',
'FGFR2',
'CSF1R',
'FASLG',
'FGF1',
'FGF2',
'RASGRP3',
'ETS1',
'FGF3',
'RASGRP2',
'ETS2',
'FGF4',
'IGF1R',
'FGF5',
'RASGRP4',
'FGF6',
'FGF7',
'FGF8',
'RASGRP1',
'FGF9',
'ABL2',
'ABL1',
'ANGPT4',
'RASA4B',
'PLA2G2E',
'PLA2G2F',
'ANGPT2',
'KSR2',
'PLA2G2C',
'ANGPT1',
'KSR1',
'PLA2G2D',
'PLA2G2A',
'PTPN11',
'RASA1',
'PIK3CB',
'RASA4',
'PIK3CA',
'RASA2',
'RASA3',
'NF1',
'SOS2',
'LAT',
'SOS1',
'SHC3',
'SHC4',
'SHC1',
'RASGRF1',
'SHC2',
'RASGRF2',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'MLLT4',
'PLD2',
'PLD1',
'STK4',
'RALGDS',
'PLA2G12A',
'PLA2G12B',
'CHUK',
'NGF',
'TIAM1',
'CDC42',
'PLA2G16',
'ZAP70',
'PLA2G10',
'MET',
'KRAS',
'FLT1',
'PLA2G1B',
'FLT4',
'PIK3CD',
'INS',
'PIK3CG',
'SYNGAP1',
'MAPK9',
'MAPK8',
'MAPK3',
'MAPK1'],
'Rap1 signaling pathway Homo sapiens hsa04015': ['EGF',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'TEK',
'CALM2',
'PFN2',
'EPHA2',
'TLN2',
'CALM3',
'PFN1',
'SKAP1',
'TLN1',
'PFN4',
'CALM1',
'PFN3',
'RALB',
'ADCY1',
'CALML6',
'RALA',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'PARD6G',
'ADCY6',
'CRKL',
'PARD6A',
'ACTB',
'PARD6B',
'AKT3',
'AKT1',
'PLCE1',
'AKT2',
'KDR',
'NGFR',
'PRKCG',
'INSR',
'PRKCI',
'PARD3',
'PRKCB',
'IGF1',
'PRKCA',
'VASP',
'PRKCZ',
'PIK3R1',
'PRKD1',
'PRKD3',
'PRKD2',
'PDGFC',
'LPAR2',
'PDGFB',
'LPAR3',
'PDGFA',
'LPAR4',
'LPAR5',
'LPAR1',
'GRIN2B',
'GRIN2A',
'RASSF5',
'PDGFD',
'PLCG1',
'RHOA',
'VEGFC',
'BRAF',
'VAV2',
'VEGFA',
'VEGFB',
'APBB1IP',
'MRAS',
'KITLG',
'ID1',
'RAPGEF2',
'RAPGEF3',
'RAPGEF1',
'RAPGEF6',
'RAPGEF4',
'RAPGEF5',
'FPR1',
'RAP1A',
'RAP1B',
'RRAS',
'FARP2',
'PLCB4',
'KIT',
'PLCB2',
'PLCB3',
'SIPA1',
'F2RL3',
'PLCB1',
'CTNNB1',
'SIPA1L3',
'GNAI1',
'GNAI2',
'GNAI3',
'SIPA1L1',
'SIPA1L2',
'RAC3',
'HRAS',
'RAC1',
'RAC2',
'PDGFRB',
'PDGFRA',
'GRIN1',
'RAF1',
'FIGF',
'CTNND1',
'CSF1',
'RGS14',
'ITGA2B',
'EFNA5',
'EGFR',
'NRAS',
'CDH1',
'FGF21',
'FGF20',
'FGF23',
'FGF22',
'MAP2K2',
'MAP2K3',
'F2R',
'MAP2K1',
'HGF',
'PGF',
'EFNA2',
'FGF18',
'EFNA1',
'FGF17',
'EFNA4',
'FGF16',
'EFNA3',
'GNAQ',
'FGF19',
'FGF10',
'FGFR1',
'GNAS',
'FGF14',
'FGF13',
'FGFR4',
'FGF12',
'FGFR3',
'FGF11',
'FGFR2',
'CSF1R',
'DOCK4',
'ACTG1',
'FGF1',
'FGF2',
'RASGRP3',
'FGF3',
'RASGRP2',
'FGF4',
'IGF1R',
'FGF5',
'FGF6',
'FGF7',
'FGF8',
'FGF9',
'MAP2K6',
'ANGPT4',
'ANGPT2',
'ANGPT1',
'ARAP3',
'PIK3CB',
'ADORA2B',
'PIK3CA',
'GNAO1',
'ADORA2A',
'LCP2',
'LAT',
'BCAR1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'MLLT4',
'RAP1GAP',
'P2RY1',
'DRD2',
'RALGDS',
'MAGI2',
'MAGI1',
'MAGI3',
'NGF',
'TIAM1',
'CDC42',
'CRK',
'MET',
'KRAS',
'ITGB2',
'ITGB1',
'SRC',
'FLT1',
'FLT4',
'ITGB3',
'THBS1',
'PIK3CD',
'ITGAM',
'INS',
'ITGAL',
'PIK3CG',
'FYB',
'CNR1',
'MAPK3',
'KRIT1',
'MAPK1'],
'Regulation of actin cytoskeleton Homo sapiens hsa04810': ['EGF',
'ACTN4',
'ACTN3',
'ACTN2',
'ACTN1',
'MYL5',
'MYL7',
'APC',
'MYL2',
'PFN2',
'MYL9',
'PFN1',
'PFN4',
'PFN3',
'CYFIP2',
'CYFIP1',
'ARPC5L',
'ARAF',
'MYL12B',
'CRKL',
'ACTB',
'MYL10',
'PIP4K2A',
'PIP4K2B',
'PIP4K2C',
'NCKAP1L',
'PTK2',
'MYL12A',
'MYLPF',
'PIK3R1',
'EZR',
'PDGFC',
'PDGFB',
'PDGFA',
'MYLK',
'PDGFD',
'PIP5K1A',
'PIP5K1B',
'PIP5K1C',
'CD14',
'RHOA',
'RDX',
'INSRR',
'FN1',
'BRAF',
'VAV1',
'GNG12',
'VAV2',
'ENAH',
'VAV3',
'MRAS',
'ARHGEF4',
'ARHGEF6',
'ARHGEF7',
'ARPC1A',
'ARHGEF1',
'ARPC1B',
'IQGAP1',
'IQGAP2',
'IQGAP3',
'RRAS2',
'RRAS',
'APC2',
'F2',
'WAS',
'WASL',
'TMSB4X',
'TMSB4Y',
'RAC3',
'HRAS',
'RAC1',
'RAC2',
'GIT1',
'GSN',
'PDGFRB',
'PDGFRA',
'PPP1CA',
'PPP1CB',
'ITGA10',
'MOS',
'ITGA11',
'ABI2',
'RAF1',
'CHRM3',
'CHRM4',
'CHRM1',
'ROCK1',
'CHRM2',
'ROCK2',
'ITGA2B',
'CHRM5',
'FGD1',
'EGFR',
'SLC9A1',
'FGD3',
'ARHGAP35',
'PPP1CC',
'NRAS',
'PAK2',
'PAK1',
'CFL2',
'CFL1',
'FGF21',
'MYH14',
'FGF20',
'PAK7',
'PAK4',
'MYH10',
'PAK3',
'FGF23',
'PAK6',
'FGF22',
'ARHGEF12',
'MAP2K2',
'F2R',
'MAP2K1',
'ARPC5',
'SSH3',
'SSH1',
'SSH2',
'DIAPH1',
'FGF18',
'DIAPH2',
'FGF17',
'DIAPH3',
'FGF16',
'ARPC3',
'ARPC4',
'ARPC2',
'FGF19',
'FGF10',
'FGFR1',
'FGF14',
'FGF13',
'FGFR4',
'FGF12',
'FGFR3',
'VCL',
'FGF11',
'FGFR2',
'PXN',
'ACTG1',
'FGF1',
'FGF2',
'FGF3',
'FGF4',
'FGF5',
'FGF6',
'FGF7',
'FGF8',
'FGF9',
'ITGA1',
'PPP1R12A',
'PPP1R12B',
'LIMK1',
'ITGA5',
'ITGA4',
'MSN',
'ITGA3',
'LIMK2',
'ITGA2',
'BAIAP2',
'ITGAE',
'PIK3CB',
'ITGAD',
'PIK3CA',
'PIKFYVE',
'ITGA9',
'MYH9',
'ITGA8',
'ITGA7',
'ITGA6',
'PPP1R12C',
'SOS2',
'DOCK1',
'BCAR1',
'SOS1',
'PIK3R5',
'BRK1',
'PIK3R3',
'PIK3R2',
'SCIN',
'BDKRB1',
'BDKRB2',
'WASF1',
'WASF2',
'TIAM1',
'CDC42',
'CRK',
'KRAS',
'ITGB2',
'MYLK2',
'MYLK3',
'ITGB1',
'SRC',
'ITGB6',
'ITGB5',
'NCKAP1',
'ITGB4',
'ITGB3',
'PIK3CD',
'ITGAM',
'INS',
'ITGAL',
'MYLK4',
'PIK3CG',
'GNA12',
'GNA13',
'MAPK3',
'ITGAX',
'ITGB8',
'MAPK1',
'ITGB7',
'ITGAV'],
'Focal adhesion Homo sapiens hsa04510': ['EGF',
'ACTN4',
'ACTN3',
'BAD',
'ACTN2',
'ACTN1',
'MYL5',
'COL1A2',
'COL1A1',
'MYL7',
'MAPK10',
'MYL2',
'COL9A2',
'COL9A1',
'COL9A3',
'MYL9',
'TLN2',
'TLN1',
'MYL12B',
'CRKL',
'ACTB',
'AKT3',
'MYL10',
'AKT1',
'AKT2',
'KDR',
'PRKCG',
'PRKCB',
'IGF1',
'PRKCA',
'PTK2',
'VASP',
'COL2A1',
'MYL12A',
'MYLPF',
'PIK3R1',
'GRB2',
'PDGFC',
'PDGFB',
'PDGFA',
'ELK1',
'MYLK',
'PDGFD',
'PIP5K1C',
'RHOA',
'JUN',
'VEGFC',
'FN1',
'BRAF',
'VAV1',
'VAV2',
'VEGFA',
'VAV3',
'VEGFB',
'RAPGEF1',
'RAP1A',
'RAP1B',
'COL4A1',
'COL4A3',
'COL4A2',
'COL4A5',
'XIAP',
'COL4A4',
'COL4A6',
'CTNNB1',
'RAC3',
'HRAS',
'RAC1',
'RAC2',
'PDGFRB',
'PDGFRA',
'PPP1CA',
'PPP1CB',
'ITGA10',
'ITGA11',
'ZYX',
'RAF1',
'FIGF',
'ROCK1',
'ROCK2',
'TNXB',
'ITGA2B',
'TNC',
'EGFR',
'ARHGAP35',
'PPP1CC',
'COMP',
'RELN',
'TNN',
'PAK2',
'CCND3',
'PAK1',
'CCND2',
'CCND1',
'TNR',
'FLNA',
'FLNB',
'PAK7',
'FLNC',
'SPP1',
'CAPN2',
'PAK4',
'PAK3',
'PAK6',
'MAP2K1',
'HGF',
'PGF',
'DIAPH1',
'COL6A1',
'COL6A3',
'COL6A2',
'COL6A5',
'COL6A6',
'BIRC2',
'BIRC3',
'VCL',
'PXN',
'ACTG1',
'VTN',
'IGF1R',
'ARHGAP5',
'IBSP',
'CHAD',
'ITGA1',
'PPP1R12A',
'PPP1R12B',
'LAMB4',
'ITGA5',
'CAV3',
'LAMB3',
'ITGA4',
'CAV2',
'ITGA3',
'CAV1',
'ITGA2',
'PARVB',
'LAMB2',
'LAMB1',
'PARVA',
'PIK3CB',
'PIK3CA',
'PARVG',
'ITGA9',
'ITGA8',
'BCL2',
'ITGA7',
'ITGA6',
'PPP1R12C',
'SOS2',
'DOCK1',
'BCAR1',
'SOS1',
'SHC3',
'GSK3B',
'SHC4',
'SHC1',
'RASGRF1',
'SHC2',
'ILK',
'LAMC1',
'PIK3R5',
'LAMC3',
'PIK3R3',
'LAMC2',
'PIK3R2',
'ERBB2',
'VWF',
'PDPK1',
'CDC42',
'CRK',
'MET',
'MYLK2',
'MYLK3',
'ITGB1',
'SRC',
'FLT1',
'LAMA3',
'ITGB6',
'LAMA2',
'ITGB5',
'FLT4',
'LAMA5',
'ITGB4',
'LAMA4',
'ITGB3',
'PTEN',
'LAMA1',
'THBS1',
'PIK3CD',
'THBS3',
'THBS2',
'MYLK4',
'THBS4',
'PIK3CG',
'MAPK9',
'MAPK8',
'MAPK3',
'ITGB8',
'MAPK1',
'FYN',
'ITGB7',
'ITGAV'],
'ECM-receptor interaction Homo sapiens hsa04512': ['ITGA1',
'LAMB4',
'ITGA5',
'LAMB3',
'ITGA4',
'ITGA3',
'ITGA2',
'FN1',
'GP5',
'LAMB2',
'LAMB1',
'GP6',
'GP9',
'COL1A2',
'COL1A1',
'ITGA10',
'ITGA11',
'COL9A2',
'ITGA9',
'COL9A1',
'ITGA8',
'ITGA7',
'COL9A3',
'ITGA6',
'AGRN',
'TNXB',
'ITGA2B',
'SDC4',
'HMMR',
'LAMC1',
'TNC',
'LAMC3',
'LAMC2',
'COMP',
'RELN',
'TNN',
'SV2C',
'SV2B',
'SV2A',
'TNR',
'DAG1',
'SPP1',
'CD36',
'VWF',
'GP1BB',
'GP1BA',
'COL2A1',
'COL4A1',
'HSPG2',
'COL6A1',
'COL4A3',
'COL4A2',
'COL6A3',
'COL4A5',
'COL6A2',
'COL4A4',
'COL6A5',
'SDC1',
'COL4A6',
'COL6A6',
'CD47',
'CD44',
'ITGB1',
'LAMA3',
'ITGB6',
'LAMA2',
'ITGB5',
'LAMA5',
'ITGB4',
'LAMA4',
'ITGB3',
'LAMA1',
'THBS1',
'THBS3',
'THBS2',
'VTN',
'THBS4',
'IBSP',
'CHAD',
'ITGB8',
'ITGB7',
'ITGAV'],
'PI3K-Akt signaling pathway Homo sapiens hsa04151': ['EGF',
'BAD',
'PPP2R1A',
'COL1A2',
'COL1A1',
'C8ORF44-SGK3',
'LPAR6',
'COL9A2',
'MTCP1',
'TEK',
'COL9A1',
'COL9A3',
'EPHA2',
'TP53',
'ATF2',
'PRKAA2',
'IL2RG',
'PRKAA1',
'GNG2',
'CREB3L1',
'GNG4',
'GNG3',
'CREB3L4',
'MYB',
'GNG5',
'CREB3L2',
'AKT3',
'GNG8',
'CREB3L3',
'MYC',
'GNG7',
'AKT1',
'AKT2',
'KDR',
'NGFR',
'INSR',
'IGF1',
'PRKCA',
'PTK2',
'COL2A1',
'PIK3R1',
'GRB2',
'ATF4',
'PDGFC',
'LPAR2',
'PDGFB',
'LPAR3',
'PDGFA',
'LPAR4',
'LPAR5',
'LPAR1',
'TCL1B',
'GNG11',
'TCL1A',
'GNG10',
'CD19',
'PDGFD',
'MLST8',
'VEGFC',
'FN1',
'GNG13',
'OSMR',
'GNG12',
'VEGFA',
'VEGFB',
'TLR2',
'KITLG',
'SGK2',
'SGK3',
'TLR4',
'SGK1',
'PRL',
'BRCA1',
'GNGT2',
'GNGT1',
'PCK2',
'PCK1',
'SYK',
'PPP2CA',
'COL4A1',
'COL4A3',
'KIT',
'COL4A2',
'CCNE2',
'COL4A5',
'CCNE1',
'COL4A4',
'PKN1',
'COL4A6',
'PKN3',
'PKN2',
'IFNA6',
'IFNA5',
'PHLPP1',
'IFNA8',
'CDKN1B',
'PHLPP2',
'IFNA7',
'IFNA2',
'CDKN1A',
'IFNA1',
'IFNA4',
'GYS1',
'PPP2CB',
'IKBKB',
'RPTOR',
'GYS2',
'HRAS',
'RAC1',
'IFNB1',
'JAK3',
'IKBKG',
'JAK1',
'JAK2',
'G6PC',
'PDGFRB',
'PDGFRA',
'IL4R',
'PRLR',
'RPS6',
'OSM',
'TSC2',
'TSC1',
'ITGA10',
'ITGA11',
'RAF1',
'FIGF',
'RELA',
'CSF3R',
'EPO',
'CHRM1',
'CSF3',
'CHRM2',
'TNXB',
'ATF6B',
'CSF1',
'CRTC2',
'ITGA2B',
'TNC',
'EFNA5',
'EGFR',
'FOXO3',
'HSP90B1',
'COMP',
'NRAS',
'BCL2L11',
'RELN',
'TNN',
'RXRA',
'CCND3',
'CCND2',
'CCND1',
'TNR',
'FGF21',
'FGF20',
'SPP1',
'FGF23',
'FGF22',
'IFNA13',
'MAP2K2',
'IFNA14',
'F2R',
'IFNA16',
'MAP2K1',
'IFNA17',
'HGF',
'NFKB1',
'PGF',
'CREB3',
'EFNA2',
'FGF18',
'EFNA1',
'FGF17',
'EIF4E1B',
'CREB1',
'EFNA4',
'FGF16',
'EFNA3',
'COL6A1',
'RHEB',
'GNB1',
'COL6A3',
'GNB3',
'COL6A2',
'FGF19',
'GNB2',
'COL6A5',
'FGF10',
'FGFR1',
'BCL2L1',
'GNB5',
'GNB4',
'COL6A6',
'FGF14',
'FGF13',
'FGFR4',
'CREB5',
'FGF12',
'FGFR3',
'IFNA10',
'IFNAR1',
'MDM2',
'FGF11',
'FGFR2',
'IL7R',
'IFNAR2',
'CSF1R',
'IRS1',
'CSH2',
'CSH1',
'EIF4EBP1',
'FASLG',
'FGF1',
'FGF2',
'FGF3',
'NR4A1',
'VTN',
'FGF4',
'IGF1R',
'FGF5',
'FGF6',
'FGF7',
'STK11',
'FGF8',
'FGF9',
'THEM4',
'IBSP',
'CHAD',
'IL6R',
'IFNA21',
'ITGA1',
'ANGPT4',
'HSP90AA1',
'LAMB4',
'ITGA5',
'ANGPT2',
'LAMB3',
'ITGA4',
'ANGPT1',
'ITGA3',
'ITGA2',
'PPP2R5C',
'PPP2R5B',
'PPP2R5E',
'LAMB2',
'PPP2R5D',
'LAMB1',
'G6PC2',
'PPP2R5A',
'GH1',
'IL3',
'IL2',
'GH2',
'IL4',
'IL7',
'G6PC3',
'RBL2',
'IL6',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'IL3RA',
'ITGA9',
'CDK2',
'ITGA8',
'BCL2',
'ITGA7',
'ITGA6',
'SOS2',
'EIF4E2',
'SOS1',
'EIF4B',
'YWHAG',
'GSK3B',
'YWHAE',
'YWHAB',
'LAMC1',
'PIK3R5',
'LAMC3',
'PIK3R3',
'LAMC2',
'PIK3R2',
'LOC102723407',
'GHR',
'CASP9',
'YWHAQ',
'EIF4E',
'MCL1',
'YWHAH',
'NOS3',
'VWF',
'CHUK',
'PDPK1',
'PPP2R3A',
'PPP2R3C',
'PPP2R3B',
'YWHAZ',
'NGF',
'EPOR',
'MTOR',
'PPP2R2D',
'RPS6KB2',
'PPP2R2C',
'CDC37',
'IL2RA',
'RPS6KB1',
'IL2RB',
'DDIT4',
'MET',
'KRAS',
'PIK3AP1',
'ITGB1',
'FLT1',
'LAMA3',
'ITGB6',
'HSP90AB1',
'LAMA2',
'ITGB5',
'FLT4',
'LAMA5',
'ITGB4',
'LAMA4',
'ITGB3',
'PTEN',
'PPP2R2B',
'LAMA1',
'THBS1',
'PIK3CD',
'PPP2R2A',
'THBS3',
'INS',
'THBS2',
'THBS4',
'PIK3CG',
'PPP2R1B',
'MAPK3',
'ITGB8',
'MAPK1',
'ITGB7',
'ITGAV'],
'Pathways in cancer Homo sapiens hsa05200': ['EGF',
'BAD',
'AGTR1',
'BAX',
'LEF1',
'RB1',
'RALB',
'ADCY1',
'RALA',
'ADCY5',
'ADCY4',
'ADCY3',
'FZD10',
'ADCY2',
'ARAF',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'GNG2',
'GNG4',
'GNG3',
'TFG',
'GNG5',
'AKT3',
'GNG8',
'MYC',
'GNG7',
'AKT1',
'AKT2',
'FZD2',
'PRKCG',
'FZD1',
'CREBBP',
'FZD4',
'WNT10B',
'WNT10A',
'FZD3',
'FZD6',
'FZD5',
'FZD8',
'FZD7',
'FZD9',
'PRKCB',
'PRKCA',
'AR',
'BCR',
'SPI1',
'CTBP2',
'CTBP1',
'PDGFB',
'PDGFA',
'HIF1A',
'PRKACG',
'NKX3-1',
'PLCG1',
'PLCG2',
'PRKACB',
'PRKACA',
'JUN',
'JUP',
'PTCH2',
'FN1',
'PTCH1',
'WNT9A',
'BRAF',
'WNT9B',
'PAX8',
'RARB',
'CCDC6',
'RARA',
'RET',
'WNT8B',
'WNT8A',
'SHH',
'MECOM',
'EGLN2',
'EGLN1',
'EGLN3',
'APC2',
'CDKN2A',
'STAT1',
'CDKN2B',
'STAT3',
'WNT7A',
'FOS',
'WNT7B',
'PLCB4',
'COL4A1',
'COL4A3',
'COL4A2',
'COL4A5',
'COL4A4',
'COL4A6',
'CKS2',
'PPARG',
'PLCB2',
'PLCB3',
'PPARD',
'PLCB1',
'FH',
'CDKN1B',
'CDKN1A',
'GSTP1',
'GLI2',
'GLI1',
'PTGS2',
'GLI3',
'IKBKB',
'APPL1',
'IKBKG',
'BID',
'JAK1',
'TPM3',
'ZBTB16',
'MITF',
'MSH2',
'RBX1',
'CXCL12',
'MSH3',
'MSH6',
'FIGF',
'CSF3R',
'ROCK1',
'ROCK2',
'ITGA2B',
'EGFR',
'HSP90B1',
'FOXO1',
'NRAS',
'CDH1',
'MAP2K2',
'F2R',
'MAP2K1',
'TRAF1',
'TRAF3',
'TRAF2',
'NFKB1',
'NFKB2',
'PGF',
'PIAS2',
'TRAF5',
'TRAF4',
'SMO',
'TRAF6',
'BIRC5',
'BCL2L1',
'BIRC7',
'BIRC8',
'BIRC2',
'BIRC3',
'MDM2',
'CSF1R',
'MAX',
'CUL2',
'FASLG',
'FGF1',
'FGF2',
'FGF3',
'FGF4',
'FGF5',
'FGF6',
'FGF7',
'FGF8',
'FGF9',
'TPR',
'ABL1',
'HSP90AA1',
'ITGA3',
'ITGA2',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'CDK2',
'BCL2',
'ITGA6',
'SOS2',
'SOS1',
'DVL1',
'DVL2',
'DVL3',
'RALGDS',
'PLEKHG5',
'NTRK1',
'CHUK',
'ARNT',
'MTOR',
'CDC42',
'RAD51',
'CRK',
'MET',
'CEBPA',
'ITGB1',
'HDAC1',
'HSP90AB1',
'FLT3',
'HDAC2',
'PTEN',
'PIK3CD',
'PIK3CG',
'EDNRA',
'EDNRB',
'ITGAV',
'RUNX1',
'PML',
'APC',
'MAPK10',
'LPAR6',
'TP53',
'EPAS1',
'CBLC',
'CBLB',
'CRKL',
'FLT3LG',
'E2F1',
'E2F2',
'E2F3',
'TCEB2',
'TCEB1',
'STAT5B',
'IGF1',
'PTK2',
'PIK3R1',
'GRB2',
'HHIP',
'LPAR2',
'LPAR3',
'LPAR4',
'LPAR5',
'LPAR1',
'RASSF1',
'GNG11',
'GNG10',
'RASSF5',
'STAT5A',
'SKP2',
'RHOA',
'NCOA4',
'VEGFC',
'GNG13',
'GNG12',
'VEGFA',
'VEGFB',
'KITLG',
'ARHGEF1',
'TGFA',
'KLK3',
'BRCA2',
'GNGT2',
'GNGT1',
'STK36',
'FADD',
'ARNT2',
'MLH1',
'KIT',
'CCNE2',
'XIAP',
'CCNE1',
'F2RL3',
'PTGER1',
'PTGER2',
'CTNNB1',
'PTGER3',
'PTGER4',
'GNAI1',
'GNAI2',
'GNAI3',
'CXCR4',
'EP300',
'SUFU',
'RAC3',
'CTNNA2',
'CTNNA1',
'HRAS',
'RAC1',
'RAC2',
'CTNNA3',
'TGFB1',
'PDGFRB',
'RALBP1',
'TGFB3',
'PDGFRA',
'TGFB2',
'WNT5A',
'WNT5B',
'FAS',
'RAF1',
'RELA',
'RXRA',
'RXRB',
'CCND1',
'FGF21',
'FGF20',
'RXRG',
'FGF23',
'RUNX1T1',
'FGF22',
'ARHGEF12',
'SMAD3',
'ARHGEF11',
'SMAD2',
'SMAD4',
'WNT3A',
'HGF',
'FGF18',
'FGF17',
'FGF16',
'CCNA1',
'GNB1',
'GNB3',
'GNAQ',
'FGF19',
'GNB2',
'FGF10',
'FGFR1',
'TCF7',
'GNB5',
'GNAS',
'GNB4',
'FGF14',
'FGF13',
'FGF12',
'FGFR3',
'FGF11',
'FGFR2',
'WNT2B',
'SLC2A1',
'RASGRP3',
'CSF2RA',
'ETS1',
'RASGRP2',
'IGF1R',
'RASGRP4',
'RASGRP1',
'LAMB4',
'MMP1',
'LAMB3',
'MMP2',
'AXIN2',
'AXIN1',
'LAMB2',
'LAMB1',
'MMP9',
'TGFBR1',
'TGFBR2',
'WNT16',
'BMP4',
'NFKBIA',
'BMP2',
'IL6',
'CYCS',
'CXCL8',
'GSK3B',
'LAMC1',
'PIK3R5',
'CKS1B',
'LAMC3',
'PIK3R3',
'LAMC2',
'PIK3R2',
'PLD1',
'STK4',
'WNT6',
'WNT11',
'CASP8',
'CASP9',
'ERBB2',
'BDKRB1',
'BDKRB2',
'CASP3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'DCC',
'TCF7L2',
'TCF7L1',
'DAPK2',
'DAPK1',
'DAPK3',
'KRAS',
'LAMA3',
'LAMA2',
'LAMA5',
'LAMA4',
'LAMA1',
'CBL',
'MAPK9',
'MAPK8',
'GNA11',
'GNA12',
'GNA13',
'MAPK3',
'VHL',
'MAPK1',
'NOS2'],
'Small cell lung cancer Homo sapiens hsa05222': ['LAMB4',
'LAMB3',
'APAF1',
'ITGA3',
'ITGA2',
'FN1',
'LAMB2',
'LAMB1',
'NFKBIA',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'RARB',
'CDK2',
'BCL2',
'CYCS',
'ITGA6',
'TP53',
'RB1',
'RELA',
'ITGA2B',
'LAMC1',
'PIK3R5',
'CKS1B',
'LAMC3',
'PIK3R3',
'LAMC2',
'PIK3R2',
'FHIT',
'RXRA',
'RXRB',
'CASP9',
'CCND1',
'AKT3',
'MYC',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'RXRG',
'CHUK',
'CDKN2B',
'TRAF1',
'TRAF3',
'TRAF2',
'NFKB1',
'PTK2',
'PIAS2',
'COL4A1',
'COL4A3',
'PIK3R1',
'TRAF5',
'COL4A2',
'TRAF4',
'CCNE2',
'COL4A5',
'XIAP',
'CCNE1',
'COL4A4',
'TRAF6',
'BCL2L1',
'COL4A6',
'CKS2',
'BIRC7',
'BIRC8',
'BIRC2',
'BIRC3',
'ITGB1',
'MAX',
'CDKN1B',
'LAMA3',
'LAMA2',
'LAMA5',
'LAMA4',
'PTEN',
'LAMA1',
'PIK3CD',
'PTGS2',
'PIK3CG',
'IKBKB',
'NOS2',
'ITGAV',
'IKBKG',
'SKP2'],
'Apoptosis Homo sapiens hsa04210': ['ENDOG',
'BAD',
'ERN1',
'TUBA4A',
'TUBA8',
'MAPK10',
'FAS',
'BAX',
'TP53',
'RAF1',
'RELA',
'TUBAL3',
'TNF',
'TUBA3C',
'LMNA',
'ACTB',
'NRAS',
'BCL2L11',
'TUBA3E',
'TUBA3D',
'AKT3',
'AKT1',
'AKT2',
'CAPN1',
'CAPN2',
'MAP3K5',
'MAP2K2',
'DAXX',
'MAP2K1',
'GADD45B',
'GADD45A',
'TNFRSF10D',
'TRAF1',
'GADD45G',
'TNFRSF10C',
'TNFRSF10B',
'TNFRSF10A',
'TRAF2',
'NFKB1',
'EIF2S1',
'PIK3R1',
'BIRC5',
'BCL2L1',
'MAP3K14',
'BIRC2',
'ATF4',
'BIRC3',
'ACTG1',
'HTRA2',
'PRF1',
'FASLG',
'CSF2RB',
'TP53AIP1',
'PMAIP1',
'TNFSF10',
'CTSB',
'JUN',
'APAF1',
'CFLAR',
'EIF2AK3',
'PTPN13',
'IL3',
'TNFRSF1A',
'SEPT4',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'IL3RA',
'BCL2',
'ATM',
'CYCS',
'HRK',
'DIABLO',
'BCL2A1',
'TRADD',
'ITPR2',
'PIK3R5',
'LMNB1',
'CTSZ',
'ITPR3',
'PIK3R3',
'PIK3R2',
'CTSW',
'CTSV',
'ITPR1',
'LMNB2',
'CTSS',
'BBC3',
'SPTA1',
'CASP8',
'CASP9',
'CTSO',
'CASP6',
'CASP12',
'CASP7',
'CASP10',
'CTSL',
'CTSK',
'CASP2',
'CASP3',
'FADD',
'CTSH',
'RIPK1',
'CTSF',
'MCL1',
'PIDD1',
'CTSD',
'CTSC',
'DFFB',
'PARP4',
'NTRK1',
'DFFA',
'PARP2',
'CHUK',
'PARP3',
'GZMB',
'PDPK1',
'PARP1',
'FOS',
'NGF',
'DAB2IP',
'XIAP',
'DDIT3',
'KRAS',
'PIK3CD',
'TUBA1A',
'PIK3CG',
'IKBKB',
'MAPK9',
'TUBA1C',
'MAPK8',
'TUBA1B',
'AIFM1',
'MAPK3',
'BAK1',
'HRAS',
'MAPK1',
'IKBKG',
'SPTAN1',
'BID'],
'NF-kappa B signaling pathway Homo sapiens hsa04064': ['LYN',
'UBE2I',
'IL1R1',
'CCL21',
'CFLAR',
'IRAK4',
'VCAM1',
'TICAM2',
'TICAM1',
'TNFRSF1A',
'IL1B',
'NFKBIA',
'CXCL12',
'BCL2',
'ATM',
'TLR4',
'LAT',
'CXCL8',
'RELA',
'CD40',
'TNFRSF11A',
'BCL2A1',
'TRADD',
'TNFAIP3',
'CXCL2',
'TNF',
'LY96',
'RELB',
'LOC102723407',
'IRAK1',
'LBP',
'BLNK',
'RIPK1',
'MAP3K7',
'PIDD1',
'CARD11',
'PIAS4',
'CSNK2A2',
'DDX58',
'SYK',
'CSNK2A1',
'CHUK',
'GADD45B',
'TNFSF14',
'CSNK2A3',
'PARP1',
'TRAF1',
'TIRAP',
'PRKCB',
'TRAF3',
'TRAF2',
'NFKB1',
'NFKB2',
'MYD88',
'LCK',
'ZAP70',
'LTBR',
'TRAF5',
'XIAP',
'CSNK2B',
'TRAF6',
'BCL2L1',
'LTB',
'LTA',
'BTK',
'TAB3',
'PRKCQ',
'TAB2',
'CD40LG',
'MAP3K14',
'TAB1',
'BIRC2',
'BIRC3',
'CCL13',
'CCL4L1',
'TNFRSF13C',
'CCL4L2',
'BCL10',
'PLAU',
'ICAM1',
'TNFSF13B',
'MALT1',
'PTGS2',
'IKBKB',
'CCL4',
'TNFSF11',
'TRIM25',
'PLCG1',
'ERC1',
'PLCG2',
'CCL19',
'IKBKG',
'CD14'],
'Osteoclast differentiation Homo sapiens hsa04380': ['TGFB1',
'TGFB2',
'IL1R1',
'MITF',
'TYROBP',
'MAPK13',
'MAPK14',
'TEC',
'OSCAR',
'MAPK11',
'MAPK12',
'MAPK10',
'NCF1',
'SQSTM1',
'RELA',
'CSF1',
'TNF',
'RELB',
'AKT3',
'AKT1',
'AKT2',
'MAP3K7',
'JUND',
'MAP2K1',
'CYBB',
'CYBA',
'TRAF2',
'NFKB1',
'NFKB2',
'FOSL2',
'FOSL1',
'CREB1',
'PIK3R1',
'TRAF6',
'BTK',
'GRB2',
'TAB2',
'MAP3K14',
'TAB1',
'NOX1',
'IFNAR1',
'NOX3',
'IFNAR2',
'CSF1R',
'SPI1',
'NCF2',
'SIRPG',
'NCF4',
'PPP3R1',
'CALCR',
'PPP3R2',
'SIRPA',
'TNFSF11',
'PLCG2',
'JUNB',
'MAP2K6',
'MAP2K7',
'JUN',
'GAB2',
'LILRB1',
'LILRB2',
'NFATC2',
'LILRB3',
'NFATC1',
'LILRB4',
'TYK2',
'LILRB5',
'TGFBR1',
'TGFBR2',
'TNFRSF1A',
'IL1A',
'IL1B',
'NFKBIA',
'FCGR2A',
'CYLD',
'FCGR2B',
'PIK3CB',
'PIK3CA',
'IFNG',
'CAMK4',
'IRF9',
'LCP2',
'FCGR2C',
'TNFRSF11A',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'TNFRSF11B',
'TREM2',
'SIRPB1',
'PPP3CA',
'SOCS3',
'FCGR3A',
'PPP3CB',
'FCGR3B',
'PPP3CC',
'SOCS1',
'CTSK',
'ACP5',
'BLNK',
'STAT1',
'IFNGR1',
'SYK',
'STAT2',
'IFNGR2',
'CHUK',
'FOS',
'LOC102725035',
'LCK',
'FOSB',
'PPARG',
'FHL2',
'ITGB3',
'LILRA1',
'PIK3CD',
'LILRA2',
'LILRA3',
'LILRA4',
'LILRA5',
'LILRA6',
'PIK3CG',
'IKBKB',
'MAPK9',
'FCGR1A',
'MAPK8',
'MAPK3',
'MAPK1',
'RAC1',
'IFNB1',
'FYN',
'IKBKG',
'JAK1'],
'TNF signaling pathway Homo sapiens hsa04668': ['VCAM1',
'MAPK13',
'MAPK14',
'CXCL10',
'MAPK11',
'MAPK12',
'MAPK10',
'FAS',
'ATF2',
'RELA',
'CSF2',
'ATF6B',
'CSF1',
'TNF',
'NOD2',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'AKT3',
'CREB3L3',
'AKT1',
'AKT2',
'MAP3K7',
'MAP3K8',
'MAP3K5',
'MAP2K4',
'JAG1',
'MAP2K3',
'MAP2K1',
'TRAF1',
'TRAF3',
'TRAF2',
'SELE',
'NFKB1',
'CREB3',
'CREB1',
'PIK3R1',
'TRAF5',
'TAB3',
'TAB2',
'MAP3K14',
'TAB1',
'BIRC2',
'ATF4',
'CREB5',
'BIRC3',
'ICAM1',
'BAG4',
'MLKL',
'JUNB',
'MAP2K6',
'DNM1L',
'MAP2K7',
'EDN1',
'JUN',
'IL15',
'RIPK3',
'CCL20',
'MMP3',
'VEGFC',
'CFLAR',
'LIF',
'MMP9',
'TNFRSF1A',
'TNFRSF1B',
'IL1B',
'NFKBIA',
'IL6',
'MMP14',
'PIK3CB',
'PIK3CA',
'BCL3',
'IL18R1',
'TRADD',
'PIK3R5',
'TNFAIP3',
'PIK3R3',
'CXCL2',
'PIK3R2',
'CXCL1',
'CX3CL1',
'CXCL3',
'CXCL5',
'SOCS3',
'CASP8',
'CASP7',
'CASP10',
'CASP3',
'FADD',
'RIPK1',
'CHUK',
'FOS',
'ITCH',
'DAB2IP',
'LTA',
'PGAM5',
'CEBPB',
'PIK3CD',
'PTGS2',
'PIK3CG',
'RPS6KA5',
'RPS6KA4',
'IKBKB',
'MAPK9',
'MAPK8',
'CCL5',
'MAPK3',
'MAPK1',
'CCL2',
'IKBKG'],
'NOD-like receptor signaling pathway Homo sapiens hsa04621': ['HSP90AA1',
'CARD9',
'CARD8',
'IL18',
'CARD6',
'MAPK13',
'MAPK14',
'MAPK11',
'NFKBIB',
'IL1B',
'NFKBIA',
'MAPK12',
'IL6',
'MAPK10',
'TRIP6',
'ERBB2IP',
'PYDC1',
'NAIP',
'CXCL8',
'RELA',
'MEFV',
'TNFAIP3',
'NOD1',
'CXCL2',
'TNF',
'NLRC4',
'NOD2',
'CXCL1',
'HSP90B1',
'PYCARD',
'CASP8',
'PSTPIP1',
'CASP5',
'NLRP3',
'NLRP1',
'RIPK2',
'CASP1',
'MAP3K7',
'CHUK',
'NFKB1',
'TRAF6',
'CARD18',
'SUGT1',
'TAB3',
'TAB2',
'TAB1',
'BIRC2',
'BIRC3',
'HSP90AB1',
'IKBKB',
'MAPK9',
'MAPK8',
'CCL5',
'MAPK3',
'MAPK1',
'CCL2',
'IKBKG'],
'Cytosolic DNA-sensing pathway Homo sapiens hsa04623': ['ZBP1',
'POLR3GL',
'RIPK3',
'IL18',
'TMEM173',
'CXCL10',
'NFKBIB',
'IL1B',
'NFKBIA',
'POLR3A',
'IL6',
'POLR3B',
'POLR3C',
'POLR3D',
'POLR3E',
'IRF3',
'POLR3F',
'POLR3G',
'POLR3H',
'IRF7',
'POLR3K',
'LOC101060521',
'RELA',
'ADAR',
'PYCARD',
'RIPK1',
'CASP1',
'MB21D1',
'IL33',
'IFNA13',
'IFNA14',
'DDX58',
'IFNA16',
'IFNA17',
'CHUK',
'NFKB1',
'AIM2',
'MAVS',
'POLR1C',
'POLR1D',
'IFNA10',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'CCL4L1',
'IFNA2',
'CCL4L2',
'IFNA1',
'IFNA4',
'IKBKB',
'TBK1',
'CCL5',
'POLR2E',
'CCL4',
'POLR2F',
'TREX1',
'IFNB1',
'POLR2H',
'IKBKG',
'POLR2K',
'IKBKE',
'IFNA21',
'POLR2L'],
'RIG-I-like receptor signaling pathway Homo sapiens hsa04622': ['MAP3K1',
'TMEM173',
'DAK',
'MAPK13',
'MAPK14',
'ATG12',
'CXCL10',
'MAPK11',
'NFKBIB',
'IFNE',
'NFKBIA',
'MAPK12',
'CYLD',
'MAPK10',
'SIKE1',
'IRF3',
'TBKBP1',
'IFNK',
'IRF7',
'CXCL8',
'OTUD5',
'RELA',
'NLRX1',
'DDX3X',
'TRADD',
'TNF',
'TANK',
'CASP8',
'CASP10',
'FADD',
'RIPK1',
'MAP3K7',
'AZI2',
'IFNA13',
'IFNA14',
'DDX58',
'IFNA16',
'IFNA17',
'CHUK',
'TRAF3',
'TRAF2',
'ISG15',
'NFKB1',
'IFNW1',
'RNF125',
'MAVS',
'TRAF6',
'IFNA10',
'PIN1',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'IFIH1',
'IKBKB',
'MAPK9',
'MAPK8',
'TBK1',
'DHX58',
'TRIM25',
'IFNB1',
'IL12B',
'IL12A',
'IKBKG',
'IKBKE',
'IFNA21',
'ATG5'],
'Toll-like receptor signaling pathway Homo sapiens hsa04620': ['TICAM2',
'TICAM1',
'MAPK13',
'MAPK14',
'CXCL10',
'MAPK11',
'CXCL11',
'MAPK12',
'MAPK10',
'TOLLIP',
'CD86',
'RELA',
'CD80',
'TNF',
'AKT3',
'AKT1',
'AKT2',
'SPP1',
'MAP3K7',
'MAP3K8',
'MAP2K4',
'IFNA13',
'MAP2K2',
'IFNA14',
'MAP2K3',
'IFNA16',
'MAP2K1',
'IFNA17',
'TIRAP',
'TRAF3',
'NFKB1',
'MYD88',
'PIK3R1',
'TRAF6',
'TAB2',
'TAB1',
'IFNA10',
'IFNAR1',
'IFNAR2',
'CCL4L1',
'CCL4L2',
'TBK1',
'IL12B',
'IL12A',
'CD14',
'IFNA21',
'MAP2K6',
'MAP2K7',
'JUN',
'IRAK4',
'TLR2',
'IL1B',
'NFKBIA',
'TLR1',
'IL6',
'PIK3CB',
'PIK3CA',
'IRF5',
'IRF3',
'TLR9',
'TLR8',
'IRF7',
'TLR7',
'TLR6',
'TLR5',
'TLR4',
'TLR3',
'CXCL8',
'CD40',
'CXCL9',
'CCL3L1',
'CCL3L3',
'PIK3R5',
'PIK3R3',
'LY96',
'PIK3R2',
'CASP8',
'IRAK1',
'CTSK',
'LBP',
'FADD',
'RIPK1',
'STAT1',
'CHUK',
'FOS',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'PIK3CD',
'PIK3CG',
'IKBKB',
'MAPK9',
'MAPK8',
'CCL5',
'MAPK3',
'CCL4',
'CCL3',
'MAPK1',
'RAC1',
'IFNB1',
'IKBKG',
'IKBKE'],
'Hepatitis C Homo sapiens hsa05160': ['EGF',
'BAD',
'PPP2R1A',
'TICAM1',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'MAPK10',
'TP53',
'RAF1',
'RELA',
'CD81',
'TNF',
'ARAF',
'CLDN3',
'CLDN2',
'EGFR',
'CLDN1',
'NRAS',
'RXRA',
'AKT3',
'AKT1',
'AKT2',
'LDLR',
'IFNA13',
'IFNA14',
'DDX58',
'IFNA16',
'IFNA17',
'TRAF3',
'TRAF2',
'PIAS1',
'NFKB1',
'EIF2S1',
'OCLN',
'MAVS',
'PIK3R1',
'TRAF6',
'PSME3',
'GRB2',
'IFNA10',
'IFNAR1',
'IFNAR2',
'IFIT1',
'TBK1',
'IFNA21',
'EIF2AK2',
'EIF2AK1',
'EIF2AK4',
'EIF2AK3',
'BRAF',
'OAS1',
'TYK2',
'TNFRSF1A',
'CLDN11',
'IRF1',
'NFKBIA',
'CLDN10',
'CLDN16',
'PIK3CB',
'OAS2',
'CLDN15',
'PIK3CA',
'OAS3',
'CLDN14',
'IRF3',
'CLDN19',
'IRF9',
'CLDN18',
'CLDN17',
'IRF7',
'SOS2',
'SOS1',
'TLR3',
'CXCL8',
'GSK3B',
'TRADD',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'SOCS3',
'RIPK1',
'PPARA',
'STAT1',
'STAT2',
'CHUK',
'PDPK1',
'STAT3',
'NR1H3',
'PPP2CA',
'CLDN7',
'CLDN6',
'CLDN5',
'CLDN4',
'PPP2R2D',
'PPP2R2C',
'IFIT1B',
'CLDN9',
'CLDN8',
'KRAS',
'EIF3E',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'RNASEL',
'IFNA2',
'CDKN1A',
'IFNA1',
'IFNA4',
'PPP2R2B',
'PIK3CD',
'PPP2R2A',
'PIK3CG',
'PPP2CB',
'CLDN23',
'CLDN22',
'IKBKB',
'MAPK9',
'CLDN20',
'MAPK8',
'PPP2R1B',
'CLDN25',
'CLDN24',
'MAPK3',
'HRAS',
'MAPK1',
'IFNB1',
'IKBKG',
'SCARB1',
'JAK1',
'IKBKE'],
'Hepatitis B Homo sapiens hsa05161': ['TGFB1',
'MAP3K1',
'TGFB3',
'TGFB2',
'BAD',
'TICAM2',
'TICAM1',
'MAPK10',
'FAS',
'BAX',
'TP53',
'RAF1',
'ATF2',
'PCNA',
'RB1',
'RELA',
'ATF6B',
'TNF',
'CREB3L1',
'NRAS',
'CREB3L4',
'CCND1',
'CREB3L2',
'AKT3',
'CREB3L3',
'MYC',
'E2F1',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'STAT6',
'SMAD3',
'STAT5B',
'MAP2K4',
'PRKCG',
'IFNA13',
'EGR2',
'CREBBP',
'MAP2K2',
'IFNA14',
'EGR3',
'SMAD4',
'DDX58',
'IFNA16',
'MAP2K1',
'IFNA17',
'ATP6AP1',
'TIRAP',
'PRKCB',
'PRKCA',
'NFKB1',
'CREB3',
'MYD88',
'CCNA2',
'CREB1',
'HSPG2',
'CCNA1',
'MAVS',
'PIK3R1',
'BIRC5',
'GRB2',
'ATF4',
'CREB5',
'IFNA10',
'IFNAR1',
'FASLG',
'ELK1',
'TBK1',
'IFNA21',
'STAT5A',
'JUN',
'APAF1',
'NFATC4',
'NFATC3',
'NFATC2',
'NFATC1',
'MMP9',
'TGFBR1',
'TLR2',
'NFKBIA',
'IL6',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'IRF3',
'CDK2',
'BCL2',
'CYCS',
'IRF7',
'TLR4',
'TLR3',
'CXCL8',
'DDX3X',
'YWHAB',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'CASP8',
'CASP9',
'CASP12',
'CASP10',
'YWHAQ',
'CASP3',
'FADD',
'STAT1',
'STAT2',
'CHUK',
'STAT3',
'STAT4',
'FOS',
'YWHAZ',
'DDB2',
'DDB1',
'CCNE2',
'CCNE1',
'VDAC3',
'KRAS',
'LAMTOR5',
'IFNA6',
'IFNA5',
'SRC',
'IFNA8',
'CDKN1B',
'IFNA7',
'IFNA2',
'CDKN1A',
'IFNA1',
'IFNA4',
'PTEN',
'PIK3CD',
'PIK3CG',
'IFIH1',
'IKBKB',
'MAPK9',
'MAPK8',
'EP300',
'PTK2B',
'MAPK3',
'HRAS',
'MAPK1',
'IFNB1',
'IKBKG',
'JAK1',
'IKBKE'],
'Measles Homo sapiens hsa05162': ['MX1',
'HSPA1L',
'DOK1',
'FAS',
'CD209',
'HSPA1A',
'CLEC4M',
'TP53',
'HSPA1B',
'SLAMF1',
'RELA',
'IL2RG',
'CBLB',
'RCHY1',
'CCND3',
'CCND2',
'CCND1',
'AKT3',
'AKT1',
'AKT2',
'MAP3K7',
'STAT5B',
'IFNA13',
'IFNA14',
'DDX58',
'IFNA16',
'IFNA17',
'SH2D1A',
'TNFRSF10D',
'TNFRSF10C',
'TNFRSF10B',
'TNFRSF10A',
'NFKB1',
'EIF2S1',
'TP73',
'MYD88',
'MAVS',
'PIK3R1',
'CSNK2B',
'TRAF6',
'PRKCQ',
'TAB2',
'IFNA10',
'IFNAR1',
'IFNAR2',
'FASLG',
'TBK1',
'IL12B',
'TNFSF10',
'IL12A',
'IFNA21',
'STAT5A',
'HSPA6',
'MSN',
'IL13',
'EIF2AK2',
'HSPA8',
'EIF2AK1',
'EIF2AK4',
'HSPA2',
'EIF2AK3',
'GNB2L1',
'IRAK4',
'TACR1',
'OAS1',
'TYK2',
'IL2',
'IL1A',
'TLR2',
'NFKBIB',
'IL4',
'IL1B',
'NFKBIA',
'FCGR2B',
'IL6',
'PIK3CB',
'CDK6',
'OAS2',
'PIK3CA',
'OAS3',
'CDK4',
'IRF3',
'IFNG',
'CDK2',
'CD28',
'IRF9',
'TLR9',
'IRF7',
'TLR7',
'TLR4',
'GSK3B',
'PIK3R5',
'TNFAIP3',
'PIK3R3',
'CD3G',
'PIK3R2',
'CD3E',
'ADAR',
'CD3D',
'LOC102723407',
'BBC3',
'IRAK1',
'CSNK2A2',
'STAT1',
'IFNGR1',
'CSNK2A1',
'STAT2',
'IFNGR2',
'CHUK',
'STAT3',
'CSNK2A3',
'IL2RA',
'CCNE2',
'IL2RB',
'CCNE1',
'RAB9A',
'EIF3H',
'RAB9B',
'CD46',
'IFNA6',
'IFNA5',
'IFNA8',
'CDKN1B',
'IFNA7',
'IFNA2',
'IFNA1',
'IFNA4',
'PIK3CD',
'PIK3CG',
'IFIH1',
'IFNB1',
'FYN',
'JAK3',
'JAK1',
'IKBKE',
'JAK2'],
'Influenza A Homo sapiens hsa05164': ['MX1',
'HSPA1L',
'CPSF4',
'RSAD2',
'TMPRSS13',
'TICAM1',
'MAPK13',
'MAPK14',
'PML',
'CXCL10',
'MAPK11',
'MAPK12',
'DDX39B',
'MAPK10',
'NUP98',
'FAS',
'HSPA1A',
'RAF1',
'IVNS1ABP',
'HSPA1B',
'ATF2',
'RELA',
'NLRX1',
'PRSS2',
'PRSS1',
'TNF',
'NXF1',
'NXF2',
'ACTB',
'PYCARD',
'NXF3',
'AKT3',
'PABPN1',
'AKT1',
'NLRP3',
'AKT2',
'RAE1',
'NXF5',
'HLA-DOB',
'PRSS3',
'KPNA1',
'HLA-DOA',
'KPNA2',
'MAP2K4',
'FDPS',
'IFNA13',
'CREBBP',
'MAP2K2',
'IFNA14',
'HLA-DRB5',
'MAP2K3',
'DDX58',
'IFNA16',
'MAP2K1',
'IFNA17',
'TNFRSF10D',
'TNFRSF10C',
'PRKCB',
'TNFRSF10B',
'PRKCA',
'TNFRSF10A',
'NFKB1',
'EIF2S1',
'MYD88',
'MAVS',
'PIK3R1',
'HLA-DRB4',
'HLA-DRB3',
'IFNA10',
'IFNAR1',
'NXF2B',
'HLA-DRB1',
'IFNAR2',
'ACTG1',
'FASLG',
'PABPN1L',
'ICAM1',
'TBK1',
'IL12B',
'TNFSF10',
'IL12A',
'AGFG1',
'IFNA21',
'MAP2K6',
'MAP2K7',
'JUN',
'HSPA6',
'EIF2AK2',
'HSPA8',
'EIF2AK1',
'EIF2AK4',
'HSPA2',
'EIF2AK3',
'IRAK4',
'OAS1',
'IL18',
'TYK2',
'TNFRSF1A',
'IL1A',
'NFKBIB',
'IL1B',
'NFKBIA',
'DNAJC3',
'IL6',
'PIK3CB',
'OAS2',
'PIK3CA',
'OAS3',
'IRF3',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'IRF9',
'CYCS',
'IRF7',
'TLR7',
'TLR4',
'TLR3',
'CXCL8',
'GSK3B',
'TMPRSS4',
'PIK3R5',
'TMPRSS2',
'PIK3R3',
'PIK3R2',
'ADAR',
'SOCS3',
'DNAJB1',
'CASP9',
'CASP1',
'CIITA',
'HLA-DQA2',
'BCL2L2-PABPN1',
'HLA-DQA1',
'IL33',
'STAT1',
'IFNGR1',
'STAT2',
'IFNGR2',
'HNRNPUL1',
'HLA-DPB1',
'VDAC1',
'SLC25A6',
'IFNA6',
'IFNA5',
'NXT1',
'IFNA8',
'NXT2',
'IFNA7',
'RNASEL',
'IFNA2',
'FURIN',
'IFNA1',
'IFNA4',
'PIK3CD',
'PLG',
'PIK3CG',
'XPO1',
'IFIH1',
'IKBKB',
'HLA-DMB',
'MAPK9',
'MAPK8',
'EP300',
'CCL5',
'HLA-DPA1',
'MAPK3',
'TRIM25',
'MAPK1',
'CCL2',
'IFNB1',
'HLA-DMA',
'JAK1',
'IKBKE',
'JAK2'],
'Herpes simplex infection Homo sapiens hsa05168': ['CD74',
'USP7',
'ALYREF',
'TAP2',
'TAP1',
'TICAM1',
'PPP1CA',
'MED8',
'PPP1CB',
'PML',
'HNRNPK',
'MAPK10',
'FAS',
'SRSF3',
'TBPL1',
'SRSF4',
'TBPL2',
'SRSF5',
'SRSF6',
'GTF2IRD1',
'SRSF7',
'SRSF8',
'SRSF9',
'PVRL2',
'TP53',
'PVRL1',
'GTF2I',
'RELA',
'SP100',
'SRSF1',
'SRSF2',
'TNF',
'ARNTL',
'NXF1',
'PPP1CC',
'NXF2',
'NXF3',
'NXF5',
'HLA-DOB',
'MAP3K7',
'HMGN1',
'HLA-DOA',
'TAF9B',
'IFNA13',
'CREBBP',
'IFNA14',
'HLA-DRB5',
'DAXX',
'DDX58',
'IFNA16',
'IFNA17',
'TNFSF14',
'HLA-C',
'TRAF1',
'HLA-A',
'TRAF3',
'HLA-B',
'TRAF2',
'HLA-G',
'NFKB1',
'SRPK1',
'HCFC1',
'HLA-E',
'EIF2S1',
'GLTSCR2',
'HCFC2',
'HLA-F',
'MYD88',
'MAVS',
'TRAF5',
'CSNK2B',
'TRAF6',
'UBE2R2',
'TAF4B',
'TAB2',
'HLA-DRB4',
'TAB1',
'HLA-DRB3',
'IFNA10',
'IFNAR1',
'NXF2B',
'HLA-DRB1',
'IFNAR2',
'CUL1',
'FASLG',
'CFP',
'IFIT1',
'C3',
'C5',
'TBK1',
'IL12B',
'IL12A',
'IFNA21',
'SKP1',
'SKP2',
'JUN',
'IL15',
'MCRS1',
'EIF2AK2',
'EIF2AK1',
'PILRA',
'EIF2AK4',
'PTPN11',
'EIF2AK3',
'OAS1',
'POU2F3',
'TYK2',
'TNFRSF1A',
'TLR2',
'TAF6L',
'NFKBIB',
'IL1B',
'NFKBIA',
'IL6',
'EEF1D',
'OAS2',
'OAS3',
'IRF3',
'IFNG',
'HLA-DQB1',
'HLA-DRA',
'CDK2',
'IRF9',
'TLR9',
'CDK1',
'CYCS',
'IRF7',
'TLR3',
'SOCS3',
'TAF5L',
'CASP8',
'C1QBP',
'CASP3',
'FADD',
'TNFRSF14',
'HLA-DQA2',
'HLA-DQA1',
'TBP',
'CSNK2A2',
'STAT1',
'IFNGR1',
'TAF13',
'CSNK2A1',
'STAT2',
'IFNGR2',
'CHUK',
'CSNK2A3',
'FOS',
'TAF10',
'PER3',
'PER2',
'CDC34',
'IFIT1B',
'PER1',
'LTA',
'HLA-DPB1',
'TAF6',
'TAF5',
'TAF4',
'CLOCK',
'TAF3',
'IFNA6',
'IFNA5',
'IFNA8',
'IFNA7',
'RNASEL',
'IFNA2',
'IFNA1',
'IFNA4',
'IFIH1',
'IKBKB',
'HLA-DMB',
'MAPK9',
'MAPK8',
'POLR2A',
'EP300',
'CCL5',
'HLA-DPA1',
'CCL2',
'IFNB1',
'IKBKG',
'HLA-DMA',
'JAK1',
'IKBKE',
'JAK2'],
'Epstein-Barr virus infection Homo sapiens hsa05169': ['SND1',
'ENTPD1',
'POLR2J2',
'ENTPD3',
'POLR2J3',
'HSPA1L',
'NUP214',
'ENTPD8',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'PSMC6',
'POLR3A',
'MAPK10',
'POLR3B',
'PSMC4',
'POLR3C',
'PSMC5',
'POLR3D',
'PSMC2',
'POLR3E',
'PSMC3',
'POLR3F',
'VIM',
'TBPL1',
'HSPA1A',
'POLR3G',
'TBPL2',
'PSMC1',
'POLR3H',
'POLR3K',
'TP53',
'RAN',
'HSPA1B',
'ATF2',
'RB1',
'PSMD7',
'PSMD8',
'PSMD6',
'AKT3',
'PSMD3',
'MYC',
'PSMD4',
'AKT1',
'PSMD1',
'AKT2',
'PSMD2',
'CREBBP',
'HLA-DRB5',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'SNW1',
'PIK3R1',
'CSNK2B',
'HLA-DRB4',
'HLA-DRB3',
'HLA-DRB1',
'SPI1',
'ICAM1',
'RBPJ',
'PRKACG',
'TBK1',
'CD19',
'PLCG1',
'PLCG2',
'PRKACB',
'PRKACA',
'SKP2',
'LYN',
'IL10',
'JUN',
'IL10RB',
'IL10RA',
'TYK2',
'PTMA',
'NCOR2',
'HLA-DQB1',
'FCER2',
'CD40',
'CD38',
'RIPK1',
'HLA-DQA2',
'HLA-DQA1',
'CSNK2A2',
'SYK',
'CSNK2A1',
'STAT3',
'CSNK2A3',
'NEDD4',
'HLA-DPB1',
'CD44',
'CDKN1B',
'CDKN1A',
'XPO1',
'IKBKB',
'EP300',
'HLA-DPA1',
'CD58',
'JAK3',
'IKBKG',
'JAK1',
'USP7',
'RELA',
'RBPJL',
'GTF2B',
'GTF2E1',
'GTF2E2',
'RELB',
'MAP3K7',
'MAP2K4',
'MAP2K3',
'DDX58',
'SHFM1',
'TRAF1',
'TRAF3',
'TRAF2',
'NFKB1',
'NFKB2',
'CCNA2',
'CCNA1',
'TRAF5',
'TRAF6',
'TAB2',
'MAP3K14',
'TAB1',
'MDM2',
'MAP2K6',
'MAP2K7',
'HSPA6',
'POLR3GL',
'EIF2AK2',
'HSPA8',
'EIF2AK1',
'EIF2AK4',
'HSPA2',
'EIF2AK3',
'NFKBIB',
'NFKBIA',
'PIK3CB',
'PIK3CA',
'IRF3',
'IFNG',
'HLA-DRA',
'CDK2',
'BCL2',
'CDK1',
'NFKBIE',
'LOC101060521',
'PSMD11',
'YWHAG',
'GSK3B',
'PSMD13',
'YWHAE',
'PSMD12',
'YWHAB',
'PSMD14',
'TRADD',
'PIK3R5',
'TNFAIP3',
'HSPB2',
'PIK3R3',
'PIK3R2',
'HSPB1',
'LOC102723407',
'SPN',
'IRAK1',
'YWHAQ',
'YWHAH',
'TBP',
'CR2',
'CHUK',
'YWHAZ',
'FGR',
'POLR1C',
'POLR1D',
'HDAC5',
'HDAC4',
'HDAC1',
'HDAC2',
'AKAP8L',
'PIK3CD',
'ITGAL',
'PIK3CG',
'MAPK9',
'MAPK8',
'POLR2A',
'POLR2B',
'POLR2C',
'POLR2D',
'POLR2E',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'POLR2J',
'POLR2K',
'POLR2L'],
'Viral carcinogenesis Homo sapiens hsa05203': ['SND1',
'ACTN4',
'HIST1H4L',
'ACTN3',
'BAD',
'ACTN2',
'ACTN1',
'MRPS18B',
'SCRIB',
'CDC20',
'HIST1H4A',
'HNRNPK',
'HIST1H4B',
'HIST1H4C',
'HIST1H4H',
'TBPL1',
'HIST1H4I',
'TBPL2',
'BAX',
'PSMC1',
'HIST1H4J',
'HIST1H4K',
'HIST1H4D',
'HIST1H4E',
'TP53',
'HIST1H4F',
'HIST1H4G',
'ATF2',
'RB1',
'ATP6V0D1',
'SP100',
'CREB3L1',
'CREB3L4',
'CHEK1',
'CREB3L2',
'CREB3L3',
'STAT5B',
'GTF2H2C_2',
'EGR2',
'CREBBP',
'GTF2A1L',
'EGR3',
'HLA-C',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'SNW1',
'PIK3R1',
'GRB2',
'ATF4',
'HPN',
'HDAC11',
'HDAC10',
'C3',
'RBPJ',
'PRKACG',
'PRKACB',
'PRKACA',
'STAT5A',
'SKP2',
'LYN',
'RHOA',
'JUN',
'KAT2B',
'KAT2A',
'REL',
'GTF2H2C',
'CCR8',
'CCR5',
'CCR4',
'CCR3',
'CDKN2A',
'SYK',
'CDKN2B',
'STAT3',
'RANBP1',
'GTF2H1',
'GTF2H2',
'GTF2H3',
'GTF2H4',
'DDB1',
'CCNE2',
'CCNE1',
'ATP6V0D2',
'CDKN1B',
'CDKN1A',
'HIST2H4B',
'HIST2H4A',
'EP300',
'HRAS',
'RAC1',
'HIST3H2BB',
'JAK3',
'IKBKG',
'JAK1',
'GSN',
'USP7',
'MAPKAPK2',
'IL6ST',
'RELA',
'RBPJL',
'ATF6B',
'GTF2B',
'UBE3A',
'GTF2E1',
'GTF2E2',
'NRAS',
'CCND3',
'CCND2',
'CCND1',
'TRAF1',
'TRAF3',
'TRAF2',
'NFKB1',
'NFKB2',
'HIST2H2BF',
'HIST2H2BE',
'CREB3',
'DLG1',
'CCNA2',
'CREB1',
'CCNA1',
'TRAF5',
'MAD1L1',
'CREB5',
'MDM2',
'PXN',
'H2BFM',
'PMAIP1',
'EIF2AK2',
'NFKBIA',
'RBL1',
'RBL2',
'PIK3CB',
'CDK6',
'PIK3CA',
'CDK4',
'RASA2',
'H2BFWT',
'IRF3',
'CDK2',
'IRF9',
'CDK1',
'IRF7',
'GTF2A1',
'YWHAG',
'GTF2A2',
'DDX3X',
'YWHAE',
'YWHAB',
'TRADD',
'PIK3R5',
'UBR4',
'PIK3R3',
'PIK3R2',
'CHD4',
'SCIN',
'CASP8',
'YWHAQ',
'CASP3',
'YWHAH',
'TBP',
'YWHAZ',
'CDC42',
'PKM',
'HIST1H2BA',
'LTBR',
'HIST4H4',
'DNAJA3',
'HIST1H2BG',
'HIST1H2BF',
'VDAC3',
'HIST1H2BI',
'KRAS',
'HIST1H2BH',
'HIST1H2BC',
'HIST1H2BB',
'HIST1H2BE',
'HIST1H2BD',
'HDAC5',
'HIST1H2BO',
'VAC14',
'HDAC6',
'HIST1H2BN',
'SRC',
'HDAC3',
'HDAC4',
'HDAC1',
'HIST1H2BK',
'HDAC2',
'HIST1H2BJ',
'HIST1H2BM',
'HIST1H2BL',
'SRF',
'PIK3CD',
'HDAC9',
'HDAC7',
'PIK3CG',
'HDAC8',
'POLB',
'MAPK3',
'BAK1',
'MAPK1'],
'MicroRNAs in cancer Homo sapiens hsa05206': ['DICER1',
'MIR423',
'HNRNPK',
'MARCKS',
'APC',
'MIR125B1',
'MIR125B2',
'VIM',
'TP53',
'MIR30B',
'MIR30A',
'GLS2',
'GLS',
'MIRLET7F2',
'MIR1-2',
'CRKL',
'MIRLET7F1',
'MIR1-1',
'MYC',
'E2F1',
'E2F2',
'E2F3',
'CYP1B1',
'MIR30E',
'MIR30D',
'MIR194-2',
'PRKCG',
'CREBBP',
'MIR194-1',
'FZD3',
'ST14',
'PRKCE',
'MIR9-3',
'MIR9-2',
'MIR200A',
'MIR9-1',
'MIR200B',
'MIR200C',
'PRKCB',
'PRKCA',
'MIR92A2',
'MIR92A1',
'MIR324',
'MIR135A2',
'MIR135A1',
'COMMD3-BMI1',
'GRB2',
'ZFPM2',
'EZR',
'EZH2',
'MIR29B2',
'SLC45A3',
'MIR20A',
'CDCA5',
'MIR29B1',
'PDGFB',
'PDGFA',
'MIR206',
'MIR326',
'MIR205',
'MIR215',
'SOX4',
'MIR335',
'MIR214',
'RASSF1',
'MIR331',
'MIR210',
'MIR330',
'STMN1',
'HMOX1',
'PLCG1',
'PLCG2',
'TP63',
'RHOA',
'RDX',
'MIR29C',
'MIR615',
'MIR29A',
'SIRT1',
'VEGFA',
'MIR449A',
'ZEB1',
'ZEB2',
'MMP16',
'CCNG1',
'ATM',
'MIR183',
'MIR129-1',
'MIR129-2',
'MIR520G',
'MIR17',
'MIR520H',
'MIR520C',
'BRCA1',
'SLC7A1',
'MIR30C2',
'MIR18A',
'MIR625',
'MIR30C1',
'BMI1',
'MIR520A',
'SOCS1',
'TIMP3',
'MIR195',
'MIR192',
'SERPINB5',
'APC2',
'CDKN2A',
'MIR99A',
'MIR26A1',
'MIR26A2',
'STAT3',
'MIR199B',
'MIR19A',
'MIR133A2',
'MIR133A1',
'CCNE2',
'CCNE1',
'MIR128-1',
'MIR128-2',
'CD44',
'CDKN1B',
'CDKN1A',
'MIR106B',
'MIR203A',
'MIR203B',
'HOXD10',
'PTGS2',
'IKBKB',
'RPTOR',
'EP300',
'HRAS',
'PDGFRB',
'UBE2I',
'PDGFRA',
'TGFB2',
'CDC25A',
'MIR133B',
'CDC25B',
'CDC25C',
'FOXP1',
'MIR145',
'CYP24A1',
'MIR143',
'MIR141',
'PDCD4',
'RAF1',
'ROCK1',
'TNXB',
'MIR26B',
'TNC',
'EGFR',
'NRAS',
'BCL2L11',
'TNN',
'CCND2',
'MIR155',
'CCND1',
'TNR',
'MIR181A1',
'MIR152',
'TPM1',
'MIR150',
'PAK4',
'MIR181A2',
'MAP2K2',
'MIR28',
'WNT3A',
'MAP2K1',
'MIR25',
'MIRLET7I',
'MIR15B',
'MIR27B',
'MIR15A',
'MIRLET7G',
'MIR27A',
'KIF23',
'MIR21',
'MIRLET7E',
'NFKB1',
'MIRLET7C',
'MIRLET7D',
'MIRLET7B',
'EFNA3',
'MIR181B2',
'MIR181B1',
'FSCN1',
'MDM4',
'DNMT1',
'FGFR3',
'BCL2L2',
'MDM2',
'NOTCH3',
'NOTCH4',
'NOTCH1',
'NOTCH2',
'IRS1',
'IRS2',
'TRIM71',
'PLAU',
'MIR32',
'MIR31',
'MIR602',
'PIM1',
'BMF',
'ABL1',
'MIR193B',
'MIR181C',
'MIR181D',
'ITGA5',
'DNMT3A',
'DNMT3B',
'HMGA2',
'MMP9',
'MIR125A',
'MIR345',
'MIR224',
'MIR223',
'MIR222',
'CDK6',
'MIR342',
'MIR221',
'MIR100',
'PIK3CA',
'MIR199A1',
'MIR199A2',
'BCL2',
'SOS2',
'ABCC1',
'SOS1',
'BMPR2',
'ABCB1',
'MIR10B',
'SHC4',
'MIR34C',
'MIR10A',
'SHC1',
'MIR34B',
'MIR34A',
'MIR101-1',
'MIR451A',
'PIK3R2',
'MIRLET7A1',
'MIR96',
'MIRLET7A3',
'MIR107',
'MIRLET7A2',
'MIR16-1',
'MIR16-2',
'ERBB2',
'ERBB3',
'MIR103A2',
'CASP3',
'MIR103A1',
'WNT3',
'MCL1',
'MIR19B1',
'MIR19B2',
'MIR23C',
'MIR23B',
'MIR23A',
'MIR135B',
'MIR7-3',
'MIR7-2',
'MIR7-1',
'MTOR',
'MIR126',
'MIR122',
'MIR363',
'DDIT4',
'MIR483',
'MIR101-2',
'MIR124-1',
'MIR124-2',
'SPRY2',
'MIR124-3',
'MIR103B2',
'CRK',
'MET',
'MIR103B1',
'KRAS',
'RECK',
'HDAC4',
'HDAC1',
'ITGB3',
'PTEN',
'THBS1',
'MIR146A',
'RPS6KA5',
'MIR137',
'MIR375',
'MIR494',
'MIR373',
'IGF2BP1',
'BAK1',
'MAPK1',
'MAPK7'],
'Bladder cancer Homo sapiens hsa05219': ['MAP2K2',
'EGF',
'CDKN2A',
'DAPK2',
'MMP1',
'MAP2K1',
'DAPK1',
'MMP2',
'DAPK3',
'BRAF',
'MMP9',
'VEGFA',
'UPK3A',
'CDK4',
'KRAS',
'HBEGF',
'TP53',
'FGFR3',
'RAF1',
'MDM2',
'CXCL8',
'TYMP',
'RB1',
'SRC',
'CDKN1A',
'THBS1',
'ARAF',
'EGFR',
'RPS6KA5',
'NRAS',
'RASSF1',
'CCND1',
'ERBB2',
'CDH1',
'MYC',
'E2F1',
'MAPK3',
'E2F2',
'E2F3',
'HRAS',
'MAPK1'],
'Thyroid cancer Homo sapiens hsa05216': ['MAP2K2',
'TCF7L2',
'NTRK1',
'TCF7L1',
'MAP2K1',
'TPM3',
'NCOA4',
'BRAF',
'PAX8',
'TCF7',
'CCDC6',
'PPARG',
'KRAS',
'TP53',
'LEF1',
'RET',
'CTNNB1',
'NRAS',
'RXRA',
'RXRB',
'TPR',
'CCND1',
'TFG',
'CDH1',
'MYC',
'MAPK3',
'HRAS',
'MAPK1',
'RXRG'],
'Dorso-ventral axis formation Homo sapiens hsa04320': ['MAP2K1',
'ETV6',
'ETV7',
'CPEB2',
'CPEB1',
'SPIRE2',
'SPIRE1',
'GRB2',
'KRAS',
'SOS2',
'CPEB4',
'CPEB3',
'SOS1',
'NOTCH3',
'PIWIL3',
'NOTCH4',
'PIWIL2',
'NOTCH1',
'NOTCH2',
'PIWIL4',
'FMN2',
'ETS1',
'EGFR',
'ETS2',
'MAPK3',
'MAPK1',
'PIWIL1'],
'TGF-beta signaling pathway Homo sapiens hsa04350': ['TGFB1',
'RHOA',
'ACVR1',
'TGFB3',
'TGFB2',
'SMURF2',
'SMURF1',
'BMP8B',
'PPP2R1A',
'BMP8A',
'TGFBR1',
'TGFBR2',
'ACVR2B',
'BMP7',
'RBX1',
'ACVR2A',
'BMP6',
'BMP5',
'BMP4',
'RBL1',
'ZFYVE16',
'SP1',
'BMP2',
'ID1',
'BAMBI',
'ID3',
'ID2',
'IFNG',
'MINOS1-NBL1',
'ID4',
'NBL1',
'BMPR1A',
'BMPR1B',
'BMPR2',
'ROCK1',
'ZFYVE9',
'TNF',
'MYC',
'E2F4',
'AMH',
'E2F5',
'PITX2',
'SMAD3',
'TGIF2',
'SMAD2',
'TGIF1',
'CREBBP',
'SMAD5',
'LEFTY2',
'SMAD4',
'LEFTY1',
'NOG',
'CDKN2B',
'SMAD1',
'FST',
'INHBA',
'INHBC',
'GDF5',
'INHBB',
'INHBE',
'SMAD7',
'GDF7',
'GDF6',
'SMAD6',
'SMAD9',
'PPP2CA',
'DCN',
'TFDP1',
'RPS6KB2',
'RPS6KB1',
'NODAL',
'AMHR2',
'CHRD',
'CUL1',
'THBS1',
'ACVR1C',
'LTBP1',
'ACVR1B',
'PPP2CB',
'PPP2R1B',
'EP300',
'MAPK3',
'MAPK1',
'SKP1'],
'Hippo signaling pathway Homo sapiens hsa04390': ['TGFB1',
'TGFB3',
'TGFB2',
'FBXW11',
'WNT5A',
'WNT5B',
'PPP2R1A',
'SCRIB',
'PPP1CA',
'PPP1CB',
'APC',
'AJUBA',
'LEF1',
'YAP1',
'SERPINE1',
'FZD10',
'NKD1',
'AMOT',
'PARD6G',
'PPP1CC',
'CTGF',
'PARD6A',
'ACTB',
'PARD6B',
'CCND3',
'CCND2',
'CCND1',
'CSNK1D',
'CDH1',
'MYC',
'BTRC',
'SMAD3',
'WWTR1',
'FZD2',
'SMAD2',
'FZD1',
'FZD4',
'WNT10B',
'SMAD4',
'PRKCI',
'WNT10A',
'FZD3',
'FZD6',
'WNT3A',
'FZD5',
'SMAD1',
'FZD8',
'FZD7',
'PARD3',
'FZD9',
'GDF5',
'INADL',
'CSNK1E',
'SMAD7',
'GDF7',
'GDF6',
'FRMD1',
'MOB1A',
'LATS2',
'TP73',
'MOB1B',
'LATS1',
'DLG1',
'FRMD6',
'DLG2',
'PRKCZ',
'DLG3',
'DLG4',
'BIRC5',
'TCF7',
'SNAI2',
'BIRC2',
'WNT2B',
'WWC1',
'ACTG1',
'FGF1',
'RASSF1',
'SOX2',
'RASSF6',
'TP53BP2',
'BMP8B',
'AXIN2',
'AXIN1',
'WNT9A',
'BMP8A',
'WNT9B',
'TGFBR1',
'TGFBR2',
'BMP7',
'BMP6',
'WNT16',
'BMP5',
'BMP4',
'BMP2',
'ID1',
'ID2',
'NF2',
'BMPR1A',
'BMPR1B',
'YWHAG',
'BMPR2',
'GSK3B',
'YWHAE',
'YWHAB',
'WNT8B',
'WNT8A',
'AREG',
'LIMD1',
'STK3',
'SAV1',
'BBC3',
'WNT6',
'WNT11',
'DVL1',
'DVL2',
'YWHAQ',
'DVL3',
'AMH',
'WNT1',
'TEAD1',
'WNT2',
'TEAD2',
'WNT3',
'TEAD3',
'WNT4',
'YWHAH',
'TEAD4',
'TCF7L2',
'MPP5',
'APC2',
'TCF7L1',
'WNT7A',
'WNT7B',
'WTIP',
'YWHAZ',
'PPP2CA',
'PPP2R2D',
'PPP2R2C',
'LLGL1',
'LLGL2',
'ITGB2',
'CRB2',
'CRB1',
'CTNNB1',
'PPP2R2B',
'AFP',
'PPP2R2A',
'GLI2',
'PPP2CB',
'PPP2R1B',
'CTNNA2',
'CTNNA1',
'CTNNA3'],
'Basal cell carcinoma Homo sapiens hsa05217': ['WNT5A',
'PTCH2',
'WNT5B',
'AXIN2',
'AXIN1',
'PTCH1',
'WNT9A',
'WNT9B',
'WNT16',
'BMP4',
'APC',
'BMP2',
'TP53',
'LEF1',
'GSK3B',
'WNT8B',
'FZD10',
'WNT8A',
'WNT6',
'WNT11',
'SHH',
'STK36',
'DVL1',
'DVL2',
'DVL3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'FZD2',
'FZD1',
'FZD4',
'WNT10B',
'TCF7L2',
'APC2',
'WNT10A',
'FZD3',
'TCF7L1',
'FZD6',
'WNT3A',
'FZD5',
'FZD8',
'FZD7',
'WNT7A',
'FZD9',
'WNT7B',
'SMO',
'TCF7',
'WNT2B',
'CTNNB1',
'HHIP',
'GLI2',
'GLI1',
'GLI3',
'SUFU'],
'Hedgehog signaling pathway Homo sapiens hsa04340': ['CSNK1A1',
'FBXW11',
'WNT5A',
'PTCH2',
'WNT5B',
'PTCH1',
'WNT9A',
'WNT9B',
'WNT16',
'BMP4',
'BMP2',
'GAS1',
'GSK3B',
'LRP2',
'WNT8B',
'IHH',
'WNT8A',
'WNT6',
'RAB23',
'WNT11',
'SHH',
'STK36',
'CSNK1D',
'WNT1',
'WNT2',
'WNT3',
'BTRC',
'WNT4',
'WNT10B',
'WNT10A',
'WNT3A',
'WNT7A',
'WNT7B',
'CSNK1E',
'CSNK1A1L',
'SMO',
'CSNK1G1',
'CSNK1G3',
'CSNK1G2',
'WNT2B',
'DHH',
'HHIP',
'GLI2',
'GLI1',
'GLI3',
'PRKACG',
'SUFU',
'ZIC2',
'PRKACB',
'PRKACA'],
'Wnt signaling pathway Homo sapiens hsa04310': ['FBXW11',
'WNT5A',
'CTNNBIP1',
'WNT5B',
'DKK1',
'DKK2',
'RBX1',
'DKK4',
'SFRP4',
'SFRP5',
'TBL1XR1',
'SFRP2',
'APC',
'MAPK10',
'BAMBI',
'TP53',
'LEF1',
'ROCK2',
'LRP6',
'LRP5',
'FZD10',
'SFRP1',
'NKD1',
'NKD2',
'RUVBL1',
'FRAT1',
'FRAT2',
'CCND3',
'WIF1',
'CCND2',
'CCND1',
'MYC',
'GPC4',
'SERPINF1',
'TBL1X',
'TBL1Y',
'MAP3K7',
'BTRC',
'CER1',
'SMAD3',
'FZD2',
'SIAH1',
'PRKCG',
'FZD1',
'CREBBP',
'FZD4',
'WNT10B',
'SMAD4',
'WNT10A',
'FZD3',
'FZD6',
'WNT3A',
'FZD5',
'FZD8',
'FZD7',
'FZD9',
'PRKCB',
'CSNK1E',
'PRKCA',
'VANGL2',
'VANGL1',
'FOSL1',
'CSNK2B',
'TCF7',
'WNT2B',
'CTBP2',
'CTBP1',
'CUL1',
'PSEN1',
'NLK',
'PRKACG',
'PORCN',
'PPP3R1',
'PPP3R2',
'SOX17',
'PRKACB',
'SKP1',
'PRKACA',
'RHOA',
'CSNK1A1',
'MMP7',
'JUN',
'AXIN2',
'NFATC4',
'AXIN1',
'NFATC3',
'WNT9A',
'NFATC2',
'WNT9B',
'NFATC1',
'WNT16',
'SENP2',
'GSK3B',
'CHD8',
'WNT8B',
'WNT8A',
'WNT6',
'PPP3CA',
'PPP3CB',
'WNT11',
'PPP3CC',
'DVL1',
'DVL2',
'DVL3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'TCF7L2',
'APC2',
'TCF7L1',
'CSNK2A2',
'CSNK2A1',
'CSNK2A3',
'WNT7A',
'WNT7B',
'CACYBP',
'CSNK1A1L',
'PLCB4',
'DAAM2',
'NOTUM',
'DAAM1',
'PLCB2',
'PLCB3',
'PPARD',
'PLCB1',
'CAMK2D',
'INVS',
'CAMK2A',
'CTNNB1',
'CAMK2B',
'CXXC4',
'PRICKLE1',
'PRICKLE2',
'MAPK9',
'MAPK8',
'EP300',
'RAC3',
'RAC1',
'SOST',
'RAC2',
'CAMK2G'],
'Melanogenesis Homo sapiens hsa04916': ['WNT5A',
'WNT5B',
'MITF',
'CALM2',
'CALM3',
'CALM1',
'RAF1',
'LEF1',
'ADCY1',
'CALML6',
'ADCY5',
'ADCY4',
'CALML3',
'ADCY3',
'FZD10',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'CREB3L1',
'NRAS',
'CREB3L4',
'CREB3L2',
'CREB3L3',
'FZD2',
'PRKCG',
'FZD1',
'CREBBP',
'MAP2K2',
'FZD4',
'WNT10B',
'WNT10A',
'FZD3',
'FZD6',
'WNT3A',
'MAP2K1',
'FZD5',
'FZD8',
'FZD7',
'FZD9',
'PRKCB',
'PRKCA',
'CREB3',
'CREB1',
'MC1R',
'GNAQ',
'TCF7',
'GNAS',
'WNT2B',
'PRKACG',
'PRKACB',
'PRKACA',
'EDN1',
'WNT9A',
'WNT9B',
'TYR',
'WNT16',
'KITLG',
'GNAO1',
'GSK3B',
'WNT8B',
'WNT8A',
'WNT6',
'WNT11',
'DVL1',
'DVL2',
'DVL3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'TCF7L2',
'TCF7L1',
'WNT7A',
'WNT7B',
'POMC',
'PLCB4',
'KIT',
'DCT',
'KRAS',
'PLCB2',
'PLCB3',
'PLCB1',
'CAMK2D',
'TYRP1',
'CAMK2A',
'CTNNB1',
'ASIP',
'CAMK2B',
'GNAI1',
'GNAI2',
'GNAI3',
'EDNRB',
'EP300',
'MAPK3',
'HRAS',
'MAPK1',
'CAMK2G'],
'Proteoglycans in cancer Homo sapiens hsa05205': ['LUM',
'FRS2',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'TP53',
'FZD10',
'CBLC',
'ARAF',
'CBLB',
'HPSE2',
'ACTB',
'AKT3',
'MYC',
'AKT1',
'PLCE1',
'AKT2',
'KDR',
'FZD2',
'PRKCG',
'FZD1',
'FZD4',
'WNT10B',
'WNT10A',
'FZD3',
'FZD6',
'FZD5',
'FZD8',
'FZD7',
'FZD9',
'PRKCB',
'ANK3',
'IGF1',
'PRKCA',
'IGF2',
'ANK1',
'NUDT16L1',
'ANK2',
'PTK2',
'HSPG2',
'PIK3R1',
'SDC1',
'SDC2',
'GRB2',
'NANOG',
'EZR',
'TWIST2',
'TWIST1',
'ELK1',
'HIF1A',
'PRKACG',
'PLCG1',
'IL12B',
'PLCG2',
'PRKACB',
'PRKACA',
'RHOA',
'RDX',
'FN1',
'GAB1',
'PTCH1',
'WNT9A',
'BRAF',
'WNT9B',
'VAV2',
'VEGFA',
'TLR2',
'MRAS',
'TFAP4',
'TLR4',
'ARHGEF1',
'SDC4',
'WNT8B',
'IQGAP1',
'WNT8A',
'RRAS2',
'CTSL',
'RRAS',
'TIMP3',
'STAT3',
'WNT7A',
'WNT7B',
'CTTN',
'HCLS1',
'HBEGF',
'CD44',
'CD63',
'CDKN1A',
'CTNNB1',
'HOXD10',
'HRAS',
'RAC1',
'TGFB1',
'TGFB2',
'WNT5A',
'RPS6',
'WNT5B',
'PPP1CA',
'PPP1CB',
'FAS',
'PDCD4',
'PTPN6',
'RAF1',
'ROCK1',
'ROCK2',
'TNF',
'EGFR',
'SLC9A1',
'PPP1CC',
'NRAS',
'PAK1',
'CCND1',
'GPC1',
'DROSHA',
'FLNA',
'FLNB',
'GPC3',
'FLNC',
'ARHGEF12',
'SMAD2',
'MAP2K2',
'WNT3A',
'MAP2K1',
'HGF',
'MIR21',
'ESR1',
'SMO',
'FGFR1',
'COL21A1',
'HPSE',
'MDM2',
'WNT2B',
'DDX5',
'PXN',
'ACTG1',
'PLAU',
'FASLG',
'FGF2',
'VTN',
'IGF1R',
'PPP1R12A',
'PPP1R12B',
'ITGA5',
'CAV3',
'MMP2',
'MSN',
'CAV2',
'CAV1',
'ITGA2',
'PTPN11',
'MMP9',
'WNT16',
'PIK3CB',
'PIK3CA',
'PPP1R12C',
'SOS2',
'SOS1',
'EIF4B',
'MIR10B',
'MIR10A',
'ITPR2',
'PIK3R5',
'ITPR3',
'HSPB2',
'PIK3R3',
'PIK3R2',
'ITPR1',
'WNT6',
'WNT11',
'ERBB4',
'ERBB2',
'ERBB3',
'CASP3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'PDPK1',
'PLAUR',
'MTOR',
'TIAM1',
'CDC42',
'DCN',
'RPS6KB2',
'RPS6KB1',
'MET',
'KRAS',
'CAMK2D',
'ITGB1',
'SRC',
'ITGB5',
'CAMK2A',
'CAMK2B',
'ITGB3',
'THBS1',
'PIK3CD',
'CBL',
'PIK3CG',
'MAPK3',
'MAPK1',
'ITGAV',
'CAMK2G'],
'Signaling pathways regulating pluripotency of stem cells Homo sapiens hsa04550': ['ACVR1',
'PCGF5',
'PCGF6',
'ESX1',
'PCGF3',
'WNT5A',
'WNT5B',
'LIFR',
'ISL1',
'MAPK13',
'MAPK14',
'MAPK11',
'MAPK12',
'APC',
'KAT6A',
'IL6ST',
'RAF1',
'HOXB1',
'FZD10',
'NRAS',
'AKT3',
'MYC',
'AKT1',
'AKT2',
'SMARCAD1',
'SMAD3',
'ESRRB',
'FZD2',
'SMAD2',
'FZD1',
'MAP2K2',
'SMAD5',
'FZD4',
'WNT10B',
'SMAD4',
'WNT10A',
'FZD3',
'FZD6',
'WNT3A',
'MAP2K1',
'FZD5',
'SMAD1',
'FZD8',
'FZD7',
'INHBA',
'FZD9',
'INHBC',
'IGF1',
'INHBB',
'INHBE',
'SMAD9',
'PIK3R1',
'HNF1A',
'COMMD3-BMI1',
'FGFR1',
'GRB2',
'LHX5',
'NANOG',
'TCF3',
'FGFR4',
'NODAL',
'FGFR3',
'MYF5',
'FGFR2',
'WNT2B',
'RIF1',
'FGF2',
'IGF1R',
'SOX2',
'HESX1',
'POU5F1B',
'ZFHX3',
'SETDB1',
'AXIN2',
'AXIN1',
'LIF',
'WNT9A',
'WNT9B',
'PAX6',
'DUSP9',
'ACVR2B',
'ACVR2A',
'WNT16',
'BMP4',
'BMP2',
'MEIS1',
'PIK3CB',
'ID1',
'PIK3CA',
'ID3',
'ID2',
'ID4',
'BMPR1A',
'BMPR1B',
'BMPR2',
'GSK3B',
'DLX5',
'ONECUT1',
'PIK3R5',
'WNT8B',
'PIK3R3',
'PIK3R2',
'WNT8A',
'BMI1',
'WNT6',
'WNT11',
'DVL1',
'DVL2',
'OTX1',
'DVL3',
'JARID2',
'WNT1',
'SKIL',
'WNT2',
'WNT3',
'WNT4',
'LEFTY2',
'APC2',
'STAT3',
'WNT7A',
'WNT7B',
'KLF4',
'POU5F1',
'TBX3',
'HAND1',
'REST',
'KRAS',
'NEUROG1',
'CTNNB1',
'PIK3CD',
'ACVR1C',
'ACVR1B',
'PIK3CG',
'ZIC3',
'MAPK3',
'PCGF1',
'PCGF2',
'HRAS',
'MAPK1',
'JAK3',
'JAK1',
'JAK2'],
'HTLV-I infection Homo sapiens hsa05166': ['IL1R1',
'IL1R2',
'CDC20',
'APC',
'CDC16',
'TBPL1',
'TBPL2',
'BAX',
'TLN2',
'TLN1',
'TP53',
'RAN',
'ATF2',
'RB1',
'ATF3',
'ATF1',
'ADCY1',
'TRRAP',
'ADCY5',
'ADCY4',
'ADCY3',
'FZD10',
'ADCY2',
'IL2RG',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'CDC23',
'MYB',
'CHEK1',
'CDC26',
'AKT3',
'CDC27',
'MYC',
'E2F1',
'CHEK2',
'AKT1',
'E2F2',
'AKT2',
'E2F3',
'FZD2',
'STAT5B',
'EGR1',
'FZD1',
'EGR2',
'CREBBP',
'FZD4',
'WNT10B',
'HLA-DRB5',
'WNT10A',
'FZD3',
'XBP1',
'FZD6',
'FZD5',
'FZD8',
'FZD7',
'HLA-C',
'FZD9',
'HLA-A',
'HLA-B',
'HLA-G',
'HLA-E',
'HLA-F',
'FOSL1',
'PIK3R1',
'HLA-DRB4',
'HLA-DRB3',
'ATF4',
'HLA-DRB1',
'SPI1',
'PDGFB',
'PDGFA',
'ELK1',
'ANAPC10',
'ICAM1',
'ANAPC11',
'ELK4',
'PRKACG',
'PPP3R1',
'PPP3R2',
'KAT5',
'PRKACB',
'MYBL1',
'MYBL2',
'PRKACA',
'STAT5A',
'JUN',
'IL15',
'NFATC4',
'NFATC3',
'WNT9A',
'NFATC2',
'WNT9B',
'NFATC1',
'MRAS',
'KAT2B',
'KAT2A',
'HLA-DQB1',
'ATM',
'CALR',
'ATR',
'CD40',
'WNT8B',
'CD3G',
'WNT8A',
'CD3E',
'CD3D',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'TERT',
'RRAS2',
'RRAS',
'HLA-DQA2',
'HLA-DQA1',
'RANBP3',
'CDKN2C',
'APC2',
'NFYB',
'CDKN2A',
'CDKN2B',
'RANBP1',
'WNT7A',
'FOS',
'WNT7B',
'XIAP',
'CANX',
'HLA-DPB1',
'NRP1',
'TNFRSF13C',
'CDKN1A',
'CTNNB1',
'XPO1',
'IKBKB',
'HLA-DMB',
'EP300',
'HLA-DPA1',
'HRAS',
'TSPO',
'JAK3',
'IKBKG',
'HLA-DMA',
'JAK1',
'MAP3K3',
'TGFB1',
'PDGFRB',
'MAP3K1',
'TGFB3',
'PDGFRA',
'TGFB2',
'WNT5A',
'WNT5B',
'VCAM1',
'POLE2',
'BUB1B',
'POLE3',
'POLE4',
'SLC25A31',
'MAD2L1',
'PCNA',
'RELA',
'CRTC3',
'CSF2',
'CRTC1',
'CRTC2',
'GPS2',
'TNF',
'RELB',
'NRAS',
'CCND3',
'ZFP36',
'CCND2',
'PTTG2',
'CCND1',
'PTTG1',
'MSX1',
'MSX2',
'HLA-DOB',
'HLA-DOA',
'SMAD3',
'MAP2K4',
'FDPS',
'SMAD2',
'SMAD4',
'WNT3A',
'NFKB1',
'NFKB2',
'DLG1',
'CREB1',
'BCL2L1',
'MAP3K14',
'TCF3',
'WNT2B',
'SLC2A1',
'CREM',
'ETS1',
'ETS2',
'CCNB2',
'TGFBR1',
'TGFBR2',
'TNFRSF1A',
'WNT16',
'IL2',
'NFKBIA',
'IL6',
'PIK3CB',
'PIK3CA',
'CDK4',
'HLA-DRA',
'GSK3B',
'SLC25A4',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'WNT6',
'WNT11',
'DVL1',
'DVL2',
'DVL3',
'WNT1',
'WNT2',
'WNT3',
'WNT4',
'TBP',
'IL15RA',
'CHUK',
'TP53INP1',
'LCK',
'LTBR',
'IL2RA',
'IL2RB',
'ANAPC4',
'LTA',
'ANAPC5',
'VDAC3',
'VDAC2',
'KRAS',
'ANAPC7',
'VDAC1',
'SLC25A6',
'ANAPC1',
'SLC25A5',
'ANAPC2',
'ITGB2',
'VAC14',
'SRF',
'PIK3CD',
'ITGAL',
'PIK3CG',
'POLD4',
'POLB',
'POLE',
'MAPK8',
'POLD1',
'POLD2',
'POLD3',
'BUB3'],
'Progesterone-mediated oocyte maturation Homo sapiens hsa04914': ['CDC25A',
'LOC102723555',
'CDC25B',
'MAPK13',
'MAPK14',
'CDC25C',
'MAPK11',
'MAPK12',
'MOS',
'CPEB2',
'MAPK10',
'CPEB1',
'CDC16',
'CPEB4',
'CPEB3',
'LOC100505767',
'MAD2L1',
'RAF1',
'MAD2L2',
'ADCY1',
'ADCY5',
'ADCY4',
'ADCY3',
'ADCY2',
'ARAF',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'CDC23',
'LOC102723849',
'FZR1',
'CDC26',
'AKT3',
'CDC27',
'AKT1',
'AKT2',
'PLK1',
'MAP2K1',
'SPDYC',
'IGF1',
'CCNA2',
'CCNA1',
'PIK3R1',
'SPDYA',
'PGR',
'MAD1L1',
'ANAPC13',
'PKMYT1',
'ANAPC10',
'IGF1R',
'ANAPC11',
'PRKACG',
'CCNB3',
'CCNB2',
'CCNB1',
'PRKACB',
'PRKACA',
'HSP90AA1',
'BRAF',
'SPDYE2B',
'PIK3CB',
'PIK3CA',
'CDK2',
'PDE3B',
'CDK1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'SPDYE5',
'SPDYE4',
'SPDYE6',
'LOC100996746',
'ANAPC4',
'ANAPC5',
'KRAS',
'ANAPC7',
'ANAPC1',
'ANAPC2',
'HSP90AB1',
'PIK3CD',
'INS',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'MAPK9',
'MAPK8',
'RPS6KA6',
'SPDYE1',
'RPS6KA1',
'SPDYE3',
'RPS6KA3',
'SPDYE2',
'RPS6KA2',
'MAPK3',
'MAPK1',
'BUB1'],
'Oocyte meiosis Homo sapiens hsa04114': ['FBXW11',
'PPP2R1A',
'LOC102723555',
'PPP1CA',
'RBX1',
'PPP1CB',
'CDC20',
'CDC25C',
'MAPK12',
'MOS',
'CPEB2',
'CPEB1',
'CDC16',
'CALM2',
'CPEB4',
'CALM3',
'CPEB3',
'LOC100505767',
'MAD2L1',
'CALM1',
'MAD2L2',
'ADCY1',
'CALML6',
'ADCY5',
'AURKA',
'ADCY4',
'CALML3',
'ADCY3',
'ADCY2',
'CALML5',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'PPP1CC',
'SLK',
'CDC23',
'LOC102723849',
'PTTG2',
'CDC26',
'CDC27',
'PTTG1',
'BTRC',
'PLK1',
'MAP2K1',
'SPDYC',
'IGF1',
'AR',
'STAG3',
'SPDYA',
'PGR',
'ANAPC13',
'CUL1',
'PKMYT1',
'ANAPC10',
'IGF1R',
'ANAPC11',
'SMC3',
'PRKACG',
'PPP3R1',
'PPP3R2',
'CCNB2',
'CCNB1',
'PRKACB',
'SKP1',
'PRKACA',
'PPP2R5C',
'PPP2R5B',
'PPP2R5E',
'PPP2R5D',
'SMC1B',
'SGOL1',
'SMC1A',
'PPP2R5A',
'SPDYE2B',
'ESPL1',
'CDK2',
'CDK1',
'YWHAG',
'YWHAE',
'YWHAB',
'ITPR2',
'ITPR3',
'ITPR1',
'FBXO43',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'YWHAQ',
'PLCZ1',
'YWHAH',
'REC8',
'SPDYE5',
'SPDYE4',
'SPDYE6',
'YWHAZ',
'PPP2CA',
'LOC100996746',
'CCNE2',
'CCNE1',
'ANAPC4',
'ANAPC5',
'ANAPC7',
'ANAPC1',
'ANAPC2',
'CAMK2D',
'CAMK2A',
'CAMK2B',
'INS',
'PPP2CB',
'RPS6KA6',
'SPDYE1',
'RPS6KA1',
'PPP2R1B',
'SPDYE3',
'RPS6KA3',
'SPDYE2',
'RPS6KA2',
'MAPK3',
'FBXO5',
'MAPK1',
'CAMK2G',
'BUB1'],
'Cell cycle Homo sapiens hsa04110': ['TGFB1',
'TGFB3',
'TGFB2',
'ZBTB17',
'CDC25A',
'CDC25B',
'RBX1',
'CDC20',
'CDC25C',
'BUB1B',
'CDC16',
'TP53',
'MAD2L1',
'MAD2L2',
'PCNA',
'RB1',
'CCNH',
'CDC23',
'CCND3',
'FZR1',
'CCND2',
'CHEK1',
'PTTG2',
'CCND1',
'CDC26',
'CDC27',
'MYC',
'E2F1',
'CHEK2',
'PTTG1',
'E2F2',
'E2F3',
'E2F4',
'E2F5',
'SMAD3',
'SMAD2',
'CREBBP',
'SMAD4',
'PLK1',
'GADD45B',
'GADD45A',
'GADD45G',
'CCNA2',
'STAG1',
'TFDP1',
'CCNA1',
'STAG2',
'TFDP2',
'MAD1L1',
'MDM2',
'ANAPC13',
'CDC14A',
'CUL1',
'PRKDC',
'PKMYT1',
'ANAPC10',
'ANAPC11',
'CDC14B',
'SMC3',
'CCNB3',
'CCNB2',
'CCNB1',
'SFN',
'ABL1',
'SKP1',
'SKP2',
'CDC7',
'SMC1B',
'CDC6',
'SMC1A',
'RBL1',
'RBL2',
'CDK7',
'CDK6',
'ESPL1',
'CDK4',
'CDK2',
'MCM4',
'CDK1',
'MCM5',
'ATM',
'MCM6',
'MCM7',
'ATR',
'MCM2',
'MCM3',
'YWHAG',
'GSK3B',
'YWHAE',
'YWHAB',
'ORC6',
'ORC5',
'RAD21',
'ORC2',
'ORC1',
'ORC4',
'YWHAQ',
'ORC3',
'YWHAH',
'CDKN2C',
'CDKN2D',
'CDKN2A',
'CDKN2B',
'YWHAZ',
'WEE1',
'WEE2',
'DBF4',
'CCNE2',
'CCNE1',
'ANAPC4',
'ANAPC5',
'ANAPC7',
'ANAPC1',
'ANAPC2',
'CDKN1B',
'CDKN1C',
'HDAC1',
'HDAC2',
'CDKN1A',
'TTK',
'CDC45',
'EP300',
'BUB3',
'BUB1'],
'p53 signaling pathway Homo sapiens hsa04115': ['APAF1',
'SHISA5',
'TSC2',
'CDK6',
'TP53I3',
'RRM2B',
'FAS',
'CDK4',
'CCNG2',
'CCNG1',
'CDK2',
'CDK1',
'ATM',
'BAX',
'CYCS',
'STEAP3',
'TP53',
'ATR',
'EI24',
'CD82',
'SERPINE1',
'GORAB',
'RCHY1',
'BBC3',
'CASP8',
'CCND3',
'CASP9',
'CCND2',
'CHEK1',
'CCND1',
'CHEK2',
'PERP',
'BAI1',
'CASP3',
'PIDD1',
'RPRM',
'GTSE1',
'SIAH1',
'SERPINB5',
'RRM2',
'CDKN2A',
'GADD45B',
'GADD45A',
'IGFBP3',
'GADD45G',
'TNFRSF10B',
'IGF1',
'TP73',
'DDB2',
'PPM1D',
'RFWD2',
'CCNE2',
'CCNE1',
'MDM4',
'MDM2',
'CDKN1A',
'PTEN',
'THBS1',
'CCNB3',
'TP53AIP1',
'SESN1',
'CCNB2',
'CCNB1',
'ZMAT3',
'SESN2',
'SESN3',
'PMAIP1',
'SFN',
'BID'],
'Ubiquitin mediated proteolysis Homo sapiens hsa04120': ['UBE2H',
'UBE2I',
'MAP3K1',
'PPIL2',
'FBXW7',
'FBXW11',
'UBE2C',
'FBXW8',
'UBE2F',
'FBXO2',
'UBE2A',
'UBE2B',
'HUWE1',
'MID1',
'RBX1',
'PML',
'CDC20',
'UBE2W',
'UBOX5',
'UBE2Z',
'UBE2S',
'CDC16',
'UBE2U',
'UBE2O',
'NHLRC1',
'UBE2K',
'UBE2M',
'UBE2N',
'PARK2',
'KEAP1',
'UBE2D3',
'UBE2D4',
'UBE2D1',
'UBE3A',
'UBE2D2',
'CBLC',
'UBE3B',
'RNF7',
'CBLB',
'UBE3C',
'RCHY1',
'UBE2L6',
'UBE2L3',
'CDC23',
'HERC4',
'FZR1',
'HERC3',
'HERC2',
'CDC26',
'HERC1',
'CDC27',
'TCEB2',
'TCEB1',
'BTRC',
'SIAH1',
'PIAS4',
'FANCL',
'PIAS1',
'PIAS3',
'PIAS2',
'TRAF6',
'UBE2R2',
'BIRC6',
'UBA3',
'BIRC7',
'UBA2',
'BIRC8',
'UBA1',
'BIRC2',
'BIRC3',
'MDM2',
'SAE1',
'ANAPC13',
'CUL7',
'AIRE',
'CUL5',
'CUL3',
'CUL2',
'NEDD4L',
'CUL1',
'KLHL13',
'ANAPC10',
'RHOBTB1',
'ANAPC11',
'RHOBTB2',
'UBE2J1',
'UBE2J2',
'SKP1',
'SKP2',
'SMURF2',
'SMURF1',
'UBE2G2',
'UBE2G1',
'UBE2QL1',
'CUL4B',
'CUL4A',
'PRPF19',
'KLHL9',
'DET1',
'UBA7',
'UBA6',
'UBR5',
'BRCA1',
'SOCS3',
'SOCS1',
'UBE2Q2',
'UBE2Q1',
'WWP1',
'UBE4A',
'UBE2E2',
'WWP2',
'SYVN1',
'UBE2E3',
'UBE4B',
'UBE2E1',
'ITCH',
'DDB2',
'DDB1',
'CDC34',
'RFWD2',
'XIAP',
'NEDD4',
'ANAPC4',
'ERCC8',
'ANAPC5',
'TRIP12',
'TRIM37',
'ANAPC7',
'STUB1',
'TRIM32',
'ANAPC1',
'ANAPC2',
'MGRN1',
'CBL',
'VHL',
'UBE2NL',
'FBXO4'],
'Axon guidance Homo sapiens hsa04360': ['SEMA4A',
'EPHA6',
'SEMA4B',
'EPHA5',
'EPHA8',
'EPHA7',
'PLXNC1',
'SEMA4F',
'SEMA4C',
'SEMA4D',
'SEMA4G',
'L1CAM',
'CXCL12',
'PLXNB3',
'PLXNB2',
'PLXNB1',
'EPHA2',
'EPHA1',
'NGEF',
'EPHA4',
'EPHA3',
'SEMA5B',
'ROCK1',
'SEMA5A',
'ROCK2',
'NTN1',
'EFNA5',
'NTN3',
'NTN4',
'EFNB3',
'NRAS',
'ABLIM1',
'DPYSL2',
'EFNB2',
'PAK2',
'ABLIM2',
'PAK1',
'ABLIM3',
'DPYSL5',
'EFNB1',
'CFL2',
'CFL1',
'SLIT2',
'PAK7',
'SLIT1',
'SLIT3',
'PAK4',
'PAK3',
'PAK6',
'ARHGEF12',
'SEMA6C',
'NTNG2',
'SEMA6D',
'SEMA6A',
'SEMA6B',
'NTNG1',
'PTK2',
'EFNA2',
'EFNA1',
'EFNA4',
'EFNA3',
'PPP3R1',
'PPP3R2',
'RGS3',
'PLXNA3',
'PLXNA2',
'PLXNA1',
'ABL1',
'SRGAP3',
'SRGAP2',
'SEMA7A',
'SRGAP1',
'LRRC4C',
'RHOA',
'LIMK1',
'LIMK2',
'NFATC4',
'NFATC3',
'NFATC2',
'RHOD',
'RASA1',
'FES',
'CDK5',
'GSK3B',
'LRRC4',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'DCC',
'UNC5B',
'UNC5C',
'UNC5A',
'UNC5D',
'CDC42',
'MET',
'KRAS',
'NRP1',
'ROBO3',
'ITGB1',
'EPHB6',
'SEMA3A',
'SEMA3D',
'SEMA3E',
'SEMA3B',
'SEMA3C',
'SEMA3F',
'SEMA3G',
'GNAI1',
'GNAI2',
'ROBO1',
'RND1',
'GNAI3',
'ROBO2',
'CXCR4',
'MAPK3',
'RAC3',
'HRAS',
'MAPK1',
'RAC1',
'EPHB1',
'FYN',
'RAC2',
'EPHB3',
'EPHB2',
'NCK1',
'NCK2',
'EPHB4'],
'Endocytosis Homo sapiens hsa04144': ['EGF',
'HSPA1L',
'ZFYVE20',
'PML',
'RUFY1',
'ZFYVE16',
'HSPA1A',
'VPS25',
'VPS29',
'VPS28',
'HSPA1B',
'ZFYVE9',
'ARPC5L',
'CBLC',
'IL2RG',
'CBLB',
'SNX32',
'PARD6G',
'PARD6A',
'RAB11FIP1',
'PARD6B',
'RAB11FIP2',
'MVB12B',
'KDR',
'MVB12A',
'AP2S1',
'RAB11FIP3',
'RAB11FIP4',
'RAB11FIP5',
'PRKCI',
'IQSEC3',
'IQSEC2',
'HLA-C',
'VPS37D',
'PARD3',
'HLA-A',
'STAM',
'VPS37B',
'SNF8',
'IQSEC1',
'HLA-B',
'VPS37C',
'HLA-G',
'VPS37A',
'HLA-E',
'ARFGAP2',
'HLA-F',
'ARFGAP3',
'EHD1',
'EHD2',
'ARFGAP1',
'EHD3',
'PRKCZ',
'EHD4',
'BIN1',
'TFRC',
'NEDD4L',
'VPS26B',
'VPS26A',
'PIP5K1A',
'PIP5K1B',
'PIP5K1C',
'RHOA',
'EPS15L1',
'RAB7A',
'ARPC1A',
'RET',
'ARF5',
'RAB5C',
'ARF3',
'ARF1',
'ARPC1B',
'CLTC',
'ADRB1',
'CLTB',
'ADRB2',
'CLTA',
'ADRB3',
'SNX4',
'SNX5',
'SNX2',
'SNX3',
'SNX1',
'CLTCL1',
'EPS15',
'CCR5',
'SNX6',
'PSD',
'GBF1',
'WWP1',
'AP2B1',
'ITCH',
'RAB11A',
'RAB11B',
'KIAA0196',
'KIT',
'NEDD4',
'ARF6',
'FAM21A',
'WAS',
'KIAA1033',
'WASL',
'AP2A2',
'SNX12',
'AP2A1',
'RAB22A',
'EEA1',
'ZFYVE27',
'CXCR2',
'CXCR1',
'CXCR4',
'ADRBK2',
'ADRBK1',
'RAB8A',
'HRAS',
'LDLRAP1',
'FAM21C',
'GIT2',
'GIT1',
'TGFB1',
'SH3GLB2',
'TGFB3',
'PDGFRA',
'USP8',
'TGFB2',
'SH3GLB1',
'IST1',
'RNF41',
'RAB31',
'ACAP3',
'ACAP2',
'CAPZA2',
'RAB35',
'CAPZA3',
'CHMP4C',
'CAPZA1',
'STAMBP',
'CHMP4B',
'CHMP4A',
'STAM2',
'ASAP2',
'ASAP3',
'ACAP1',
'EGFR',
'KIF5A',
'ASAP1',
'KIF5C',
'KIF5B',
'LDLR',
'SMAD3',
'SMAD2',
'IGF2R',
'F2R',
'VTA1',
'ARPC5',
'PDCD6IP',
'RNF103-CHMP3',
'HGS',
'ARPC3',
'ARPC4',
'ARPC2',
'TRAF6',
'CHMP2B',
'CHMP3',
'CHMP2A',
'CHMP7',
'RAB5A',
'FGFR4',
'AMPH',
'RAB5B',
'FGFR3',
'CHMP5',
'MDM2',
'FGFR2',
'CHMP6',
'CSF1R',
'TSG101',
'SH3KBP1',
'IGF1R',
'CHMP1B',
'WASH1',
'SH3GL1',
'RAB4A',
'SH3GL3',
'SH3GL2',
'AP2M1',
'ARFGEF2',
'ARFGEF1',
'HSPA6',
'CAV3',
'SMURF2',
'CAV2',
'SMURF1',
'HSPA8',
'CAV1',
'ARAP3',
'HSPA2',
'ARAP1',
'ARAP2',
'TGFBR1',
'EPN1',
'DNM1',
'TGFBR2',
'EPN2',
'DNM2',
'EPN3',
'DNM3',
'RABEP1',
'DAB2',
'DNAJC6',
'VPS4A',
'VPS4B',
'AGAP3',
'AGAP2',
'PLD2',
'PLD1',
'AGAP1',
'GRK1',
'GRK4',
'GRK6',
'ERBB4',
'GRK5',
'PIP5KL1',
'CAPZB',
'GRK7',
'ERBB3',
'NTRK1',
'CDC42',
'SPG20',
'SMAP1',
'RAB10',
'IL2RA',
'IL2RB',
'VPS45',
'MET',
'FOLR4',
'FOLR3',
'SMAP2',
'FOLR2',
'FOLR1',
'SPG21',
'SRC',
'FLT1',
'WIPF1',
'WIPF2',
'WIPF3',
'ARRB2',
'CBL',
'CYTH4',
'CYTH3',
'PSD3',
'PSD2',
'ARRB1',
'PSD4',
'CCDC53',
'VPS36',
'VPS35',
'CYTH2',
'CYTH1'],
'Bacterial invasion of epithelial cells Homo sapiens hsa05100': ['RHOA',
'SEPT11',
'SEPT12',
'ITGA5',
'CAV3',
'CAV2',
'CAV1',
'SEPT1',
'SEPT2',
'FN1',
'GAB1',
'RHOG',
'SEPT6',
'DNM1',
'SEPT3',
'DNM2',
'DNM3',
'PIK3CB',
'PIK3CA',
'ELMO1',
'ELMO2',
'ELMO3',
'DOCK1',
'BCAR1',
'MAD2L2',
'ARPC1A',
'SHC3',
'SHC4',
'SHC1',
'SHC2',
'ILK',
'ARPC1B',
'PIK3R5',
'CLTC',
'ARPC5L',
'CLTB',
'PIK3R3',
'CLTA',
'CBLC',
'PIK3R2',
'CBLB',
'CD2AP',
'CRKL',
'ACTB',
'CDH1',
'CLTCL1',
'WASF1',
'WASF2',
'ARPC5',
'PTK2',
'CDC42',
'ARHGAP10',
'ARPC3',
'PIK3R1',
'ARPC4',
'CTTN',
'ARPC2',
'HCLS1',
'CRK',
'MET',
'VCL',
'ITGB1',
'SRC',
'PXN',
'ARHGEF26',
'CTNNB1',
'ACTG1',
'WAS',
'WASL',
'PIK3CD',
'CBL',
'PIK3CG',
'SEPT9',
'SEPT8',
'CTNNA2',
'CTNNA1',
'RAC1',
'CTNNA3'],
'Shigellosis Homo sapiens hsa05131': ['ITGA5',
'FBXW11',
'RHOG',
'MAPK13',
'MAPK14',
'MAPK11',
'NFKBIB',
'NFKBIA',
'MAPK12',
'MAPK10',
'ELMO1',
'ELMO2',
'ELMO3',
'PFN2',
'PFN1',
'PFN4',
'DOCK1',
'PFN3',
'MAD2L2',
'ARPC1A',
'CXCL8',
'RELA',
'ROCK1',
'ROCK2',
'ARPC1B',
'ARPC5L',
'NOD1',
'UBE2D2',
'NOD2',
'U2AF1L4',
'CRKL',
'ACTB',
'RIPK2',
'WASF1',
'WASF2',
'BTRC',
'CHUK',
'ARPC5',
'NFKB1',
'CDC42',
'DIAPH1',
'ARPC3',
'ARPC4',
'CTTN',
'ARPC2',
'HCLS1',
'CRK',
'VCL',
'CD44',
'ITGB1',
'SRC',
'ACTG1',
'WAS',
'WASL',
'U2AF1',
'LOC102724594',
'IKBKB',
'MAPK9',
'MAPK8',
'MAPK3',
'MAPK1',
'RAC1',
'ABL1',
'IKBKG',
'ATG5'],
'Salmonella infection Homo sapiens hsa05132': ['DYNC2H1',
'JUN',
'RHOG',
'IL18',
'MAPK13',
'MAPK14',
'IL1A',
'MAPK11',
'DYNC1LI1',
'IL1B',
'MAPK12',
'DYNC1LI2',
'IL6',
'MAPK10',
'IFNG',
'PLEKHM2',
'MYH9',
'PFN2',
'PFN1',
'TLR5',
'PFN4',
'TLR4',
'RAB7A',
'PFN3',
'RAB7B',
'ARPC1A',
'CXCL8',
'RELA',
'ROCK1',
'CCL3L1',
'CSF2',
'ROCK2',
'CCL3L3',
'ARPC1B',
'ARPC5L',
'CXCL2',
'NLRC4',
'CXCL1',
'KLC2',
'CXCL3',
'KLC1',
'ACTB',
'PYCARD',
'KLC4',
'KLC3',
'FLNA',
'LBP',
'MYH14',
'FLNB',
'FLNC',
'WASF1',
'CASP1',
'WASF2',
'RILP',
'MYH10',
'DYNC1I2',
'DYNC1I1',
'IFNGR1',
'IFNGR2',
'FOS',
'ARPC5',
'NFKB1',
'CDC42',
'MYD88',
'TJP1',
'ARPC3',
'ARPC4',
'ARPC2',
'PKN1',
'PKN3',
'PKN2',
'DYNC1H1',
'CCL4L1',
'CCL4L2',
'ACTG1',
'WAS',
'WASL',
'MAPK9',
'MAPK8',
'MAPK3',
'CCL4',
'CCL3',
'MAPK1',
'RAC1',
'NOS2',
'CD14'],
'Pathogenic Escherichia coli infection Homo sapiens hsa05130': ['RHOA',
'TUBB',
'TUBB2A',
'TUBA4A',
'TUBA8',
'TUBB2B',
'KRT18',
'ARHGEF2',
'TLR5',
'TLR4',
'ARPC1A',
'ROCK1',
'ROCK2',
'TUBAL3',
'ARPC1B',
'TUBB1',
'ARPC5L',
'LY96',
'TUBA3C',
'CLDN1',
'ACTB',
'TUBB8',
'TUBA3E',
'TUBA3D',
'TUBB6',
'CDH1',
'TUBB3',
'YWHAQ',
'ARPC5',
'PRKCA',
'YWHAZ',
'TUBB4B',
'TUBB4A',
'CDC42',
'OCLN',
'ARPC3',
'ARPC4',
'CTTN',
'ARPC2',
'NCL',
'HCLS1',
'EZR',
'ITGB1',
'CTNNB1',
'ACTG1',
'WAS',
'WASL',
'TUBA1A',
'TUBA1C',
'TUBA1B',
'FYN',
'ABL1',
'CD14',
'NCK1',
'NCK2'],
'Leukocyte transendothelial migration Homo sapiens hsa04670': ['ACTN4',
'ACTN3',
'ACTN2',
'ACTN1',
'VCAM1',
'MAPK13',
'MAPK14',
'MYL5',
'MAPK11',
'MAPK12',
'MYL7',
'CXCL12',
'MYL2',
'NCF1',
'MYL9',
'ROCK1',
'ROCK2',
'CTNND1',
'CLDN3',
'CLDN2',
'CLDN1',
'MYL12B',
'ARHGAP35',
'ACTB',
'CDH5',
'MYL10',
'JAM2',
'JAM3',
'PRKCG',
'CYBB',
'PRKCB',
'CYBA',
'PRKCA',
'PTK2',
'VASP',
'OCLN',
'MYL12A',
'MYLPF',
'PIK3R1',
'ESAM',
'NOX1',
'EZR',
'NOX3',
'VCL',
'NCF2',
'PXN',
'NCF4',
'TXK',
'ACTG1',
'F11R',
'ICAM1',
'ARHGAP5',
'RASSF5',
'PLCG1',
'PLCG2',
'CD99',
'RHOA',
'ITGA4',
'MMP2',
'MSN',
'RHOH',
'PTPN11',
'MMP9',
'VAV1',
'VAV2',
'VAV3',
'CLDN11',
'CLDN10',
'CLDN16',
'PIK3CB',
'CLDN15',
'PIK3CA',
'CLDN14',
'PECAM1',
'CLDN19',
'RAPGEF3',
'CLDN18',
'CLDN17',
'RAPGEF4',
'ITK',
'BCAR1',
'PIK3R5',
'PIK3R3',
'PIK3R2',
'THY1',
'MLLT4',
'RAP1A',
'RAP1B',
'CDC42',
'CLDN7',
'CLDN6',
'CLDN5',
'CLDN4',
'CLDN9',
'CLDN8',
'SIPA1',
'ITGB2',
'ITGB1',
'CTNNB1',
'PIK3CD',
'ITGAM',
'ITGAL',
'GNAI1',
'GNAI2',
'GNAI3',
'PIK3CG',
'CLDN23',
'CLDN22',
'CLDN20',
'CLDN25',
'CXCR4',
'CLDN24',
'PTK2B',
'CTNNA2',
'CTNNA1',
'RAC1',
'RAC2',
'CTNNA3'],
'Tight junction Homo sapiens hsa04530': ['ACTN4',
'ACTN3',
'ACTN2',
'ACTN1',
'TJAP1',
'PPP2R1A',
'MYL5',
'MYL7',
'MYL2',
'AMOTL1',
'MYL9',
'EPB41',
'ZAK',
'CLDN3',
'CLDN2',
'CLDN1',
'MYL12B',
'PARD6G',
'PARD6A',
'ACTB',
'NRAS',
'PARD6B',
'AKT3',
'MYL10',
'AKT1',
'MYH14',
'JAM2',
'MYH15',
'AKT2',
'MYH13',
'MYH10',
'MYH11',
'JAM3',
'MYH7B',
'YES1',
'PRKCH',
'PRKCG',
'PRKCI',
'PRKCD',
'PRKCE',
'PARD3',
'CASK',
'PRKCB',
'INADL',
'PRKCA',
'OCLN',
'MYL12A',
'PRKCZ',
'MYLPF',
'CSNK2B',
'PRKCQ',
'RAB3B',
'ACTG1',
'F11R',
'EPB41L1',
'EPB41L2',
'EPB41L3',
'RHOA',
'CGN',
'SHROOM3',
'SHROOM4',
'SHROOM1',
'ASH1L',
'SHROOM2',
'MYH1',
'CLDN11',
'MYH2',
'CLDN10',
'MYH3',
'MRAS',
'MYH4',
'CLDN16',
'CLDN15',
'CLDN14',
'CDK4',
'MYH9',
'CLDN19',
'EXOC4',
'CLDN18',
'CLDN17',
'MYH6',
'EXOC3',
'MYH7',
'MYH8',
'IGSF5',
'MLLT4',
'RRAS2',
'RRAS',
'SYMPK',
'MPDZ',
'MAGI2',
'MAGI1',
'MPP5',
'CSNK2A2',
'CSNK2A1',
'MAGI3',
'CSNK2A3',
'PPP2CA',
'CDC42',
'CLDN7',
'TJP2',
'CLDN6',
'TJP1',
'CLDN5',
'CLDN4',
'VAPA',
'PPP2R2D',
'PPP2R2C',
'CTTN',
'CLDN9',
'RAB13',
'CLDN8',
'HCLS1',
'LLGL1',
'KRAS',
'LLGL2',
'TJP3',
'CRB3',
'SRC',
'CTNNB1',
'PTEN',
'PPP2R2B',
'YBX3',
'PPP2R2A',
'GNAI1',
'GNAI2',
'GNAI3',
'PPP2CB',
'CLDN23',
'CLDN22',
'CLDN20',
'PPP2R1B',
'CLDN25',
'CLDN24',
'CTNNA2',
'CTNNA1',
'HRAS',
'CTNNA3',
'SPTAN1'],
'Adherens junction Homo sapiens hsa04520': ['PTPN1',
'RHOA',
'ACTN4',
'ACTN3',
'ACTN2',
'ACTN1',
'LMO7',
'BAIAP2',
'TGFBR1',
'TGFBR2',
'PTPRF',
'FER',
'PTPRB',
'PVRL4',
'PVRL3',
'PTPN6',
'PVRL2',
'PVRL1',
'LEF1',
'CTNND1',
'PTPRM',
'IQGAP1',
'MLLT4',
'EGFR',
'PTPRJ',
'ACTB',
'ERBB2',
'CDH1',
'WASF1',
'WASF2',
'MAP3K7',
'ACP1',
'WASF3',
'YES1',
'SMAD3',
'SMAD2',
'INSR',
'CREBBP',
'FARP2',
'TCF7L2',
'SMAD4',
'TCF7L1',
'CSNK2A2',
'CSNK2A1',
'CSNK2A3',
'SORBS1',
'PARD3',
'CDC42',
'TJP1',
'CSNK2B',
'FGFR1',
'TCF7',
'SNAI2',
'MET',
'SNAI1',
'SSX2IP',
'VCL',
'SRC',
'CTNNB1',
'ACTG1',
'WAS',
'WASL',
'NLK',
'IGF1R',
'EP300',
'MAPK3',
'RAC3',
'CTNNA2',
'CTNNA1',
'MAPK1',
'RAC1',
'FYN',
'RAC2',
'CTNNA3'],
'Arrhythmogenic right ventricular cardiomyopathy (ARVC) Homo sapiens hsa05412': ['ITGA1',
'ACTN4',
'ITGA5',
'ACTN3',
'ITGA4',
'JUP',
'CACNA2D2',
'ACTN2',
'ITGA3',
'CACNA2D1',
'ACTN1',
'ITGA2',
'CACNA2D4',
'CACNA2D3',
'DES',
'ITGA10',
'ITGA11',
'ITGA9',
'PKP2',
'DSG2',
'ITGA8',
'ITGA7',
'ITGA6',
'DSC2',
'LEF1',
'ITGA2B',
'LMNA',
'ACTB',
'CDH2',
'DAG1',
'EMD',
'DSP',
'TCF7L2',
'TCF7L1',
'CACNB2',
'CACNB3',
'CACNB4',
'TCF7',
'CACNB1',
'RYR2',
'ITGB1',
'ITGB6',
'LAMA2',
'ITGB5',
'ITGB4',
'CTNNB1',
'ITGB3',
'CACNA1C',
'ACTG1',
'ATP2A2',
'CACNA1D',
'CACNA1F',
'SLC8A1',
'CACNG7',
'CACNG8',
'SGCG',
'SGCD',
'GJA1',
'SGCB',
'SGCA',
'CACNA1S',
'CTNNA2',
'CTNNA1',
'CACNG1',
'ITGB8',
'CACNG2',
'DMD',
'ITGB7',
'ITGAV',
'CTNNA3',
'CACNG3',
'CACNG4',
'CACNG5',
'CACNG6'],
'Hypertrophic cardiomyopathy (HCM) Homo sapiens hsa05410': ['ITGA1',
'TGFB1',
'TGFB3',
'ACE',
'MYBPC3',
'TGFB2',
'ITGA5',
'TPM4',
'ITGA4',
'TPM3',
'CACNA2D2',
'ITGA3',
'TPM2',
'CACNA2D1',
'ITGA2',
'CACNA2D4',
'CACNA2D3',
'PRKAB1',
'PRKAB2',
'DES',
'ITGA10',
'IL6',
'MYL2',
'MYL3',
'ITGA11',
'ITGA9',
'ITGA8',
'ITGA7',
'ITGA6',
'MYH6',
'MYH7',
'PRKAA2',
'ITGA2B',
'TNF',
'PRKAA1',
'LMNA',
'ACTB',
'TPM1',
'DAG1',
'EMD',
'TNNC1',
'IGF1',
'CACNB2',
'CACNB3',
'CACNB4',
'TNNT2',
'CACNB1',
'RYR2',
'ITGB1',
'ITGB6',
'LAMA2',
'ITGB5',
'ITGB4',
'ITGB3',
'CACNA1C',
'ACTG1',
'PRKAG2',
'PRKAG3',
'ATP2A2',
'CACNA1D',
'PRKAG1',
'ACTC1',
'TTN',
'CACNA1F',
'SLC8A1',
'CACNG7',
'CACNG8',
'SGCG',
'SGCD',
'SGCB',
'SGCA',
'CACNA1S',
'TNNI3',
'CACNG1',
'ITGB8',
'CACNG2',
'DMD',
'ITGB7',
'ITGAV',
'CACNG3',
'CACNG4',
'CACNG5',
'CACNG6'],
'Dilated cardiomyopathy Homo sapiens hsa05414': ['ITGA1',
'TGFB1',
'TGFB3',
'MYBPC3',
'TGFB2',
'ITGA5',
'TPM4',
'ITGA4',
'TPM3',
'CACNA2D2',
'ITGA3',
'TPM2',
'CACNA2D1',
'ITGA2',
'CACNA2D4',
'CACNA2D3',
'DES',
'ITGA10',
'MYL2',
'MYL3',
'ITGA11',
'ITGA9',
'ITGA8',
'ITGA7',
'ITGA6',
'MYH6',
'MYH7',
'ADCY1',
'ITGA2B',
'ADCY5',
'ADCY4',
'ADRB1',
'ADCY3',
'TNF',
'ADCY2',
'ADCY9',
'ADCY8',
'ADCY7',
'ADCY6',
'LOC102723407',
'LMNA',
'ACTB',
'TPM1',
'DAG1',
'EMD',
'TNNC1',
'IGF1',
'CACNB2',
'CACNB3',
'CACNB4',
'TNNT2',
'GNAS',
'CACNB1',
'RYR2',
'ITGB1',
'ITGB6',
'LAMA2',
'ITGB5',
'ITGB4',
'ITGB3',
'CACNA1C',
'ACTG1',
'ATP2A2',
'CACNA1D',
'ACTC1',
'TTN',
'CACNA1F',
'SLC8A1',
'PLN',
'CACNG7',
'PRKACG',
'CACNG8',
'SGCG',
'SGCD',
'SGCB',
'SGCA',
'CACNA1S',
'TNNI3',
'CACNG1',
'ITGB8',
'CACNG2',
'DMD',
'ITGB7',
'ITGAV',
'PRKACB',
'CACNG3',
'CACNG4',
'CACNG5',
'PRKACA',
'CACNG6'],
'Cardiac muscle contraction Homo sapiens hsa04260': ['TPM4',
'TPM3',
'CACNA2D2',
'TPM2',
'CACNA2D1',
'CACNA2D4',
'CACNA2D3',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'COX7B2',
'ATP1B1',
'COX6C',
'SLC9A6',
'MYL2',
'MYL3',
'UQCRQ',
'FXYD2',
'MYL4',
'UQCRC2',
'UQCRC1',
'CYTB',
'MYH6',
'MYH7',
'COX7C',
'COX7B',
'COX4I2',
'UQCR10',
'ATP1A4',
'ATP1A3',
'ATP1A2',
'UQCR11',
'ATP1A1',
'COX6A2',
'SLC9A1',
'COX6A1',
'TPM1',
'UQCRFS1',
'COX4I1',
'COX8A',
'COX8C',
'TNNC1',
'COX7A2L',
'COX6B1',
'UQCRHL',
'COX6B2',
'CACNB2',
'CACNB3',
'CACNB4',
'TNNT2',
'CACNB1',
'RYR2',
'COX5A',
'UQCRB',
'CACNA1C',
'ATP2A2',
'CACNA1D',
'ACTC1',
'COX7A1',
'CACNA1F',
'COX5B',
'COX7A2',
'SLC8A1',
'UQCRH',
'CACNG7',
'CACNG8',
'CACNA1S',
'TNNI3',
'COX3',
'CACNG1',
'COX2',
'CACNG2',
'COX1',
'CACNG3',
'CYC1',
'CACNG4',
'CACNG5',
'CACNG6'],
'Non-alcoholic fatty liver disease (NAFLD) Homo sapiens hsa04932': ['TGFB1',
'SDHD',
'PRKAB1',
'COX7B2',
'SDHB',
'PRKAB2',
'SDHC',
'ERN1',
'SDHA',
'MAPK10',
'FAS',
'UQCRQ',
'LEP',
'UQCRC2',
'BAX',
'UQCRC1',
'RELA',
'PRKAA2',
'NDUFB11',
'NDUFB10',
'UQCR10',
'TNF',
'UQCR11',
'COX6A2',
'PRKAA1',
'NDUFC2-KCTD14',
'COX6A1',
'BCL2L11',
'RXRA',
'AKT3',
'AKT1',
'AKT2',
'NDUFV3',
'NDUFV2',
'MAP3K5',
'NDUFV1',
'SREBF1',
'INSR',
'COX8A',
'XBP1',
'COX8C',
'TRAF2',
'NFKB1',
'COX7A2L',
'EIF2S1',
'PIK3R1',
'MLXIPL',
'MAP3K11',
'ATF4',
'IRS1',
'IRS2',
'UQCRB',
'FASLG',
'COX7A1',
'COX7A2',
'UQCRH',
'LEPR',
'COX3',
'COX2',
'COX1',
'IL6R',
'CYC1',
'JUN',
'EIF2AK3',
'NDUFC2',
'NDUFC1',
'COX6C',
'TNFRSF1A',
'IL1A',
'IL1B',
'IL6',
'PIK3CB',
'NDUFS8',
'PIK3CA',
'NDUFS7',
'NDUFS6',
'NDUFS5',
'NDUFS4',
'NDUFS3',
'CYCS',
'NDUFS2',
'NDUFS1',
'CYTB',
'CXCL8',
'GSK3B',
'COX7C',
'NDUFB9',
'GSK3A',
'COX7B',
'NDUFB8',
'NDUFB7',
'NDUFB6',
'COX4I2',
'NDUFB5',
'NDUFB4',
'PIK3R5',
'NDUFB3',
'NDUFB2',
'PIK3R3',
'NDUFB1',
'PIK3R2',
'ADIPOR1',
'ADIPOR2',
'SOCS3',
'CASP8',
'CASP7',
'UQCRFS1',
'MLX',
'CASP3',
'COX4I1',
'ADIPOQ',
'NDUFA9',
'NDUFA8',
'PPARA',
'NDUFA7',
'NDUFA6',
'PKLR',
'NDUFA5',
'NR1H3',
'NDUFA4',
'NDUFA3',
'NDUFA2',
'NDUFA1',
'ITCH',
'COX6B1',
'CDC42',
'UQCRHL',
'COX6B2',
'NDUFAB1',
'NDUFA4L2',
'DDIT3',
'CYP2E1',
'CEBPA',
'COX5A',
'NDUFA12',
'NDUFA13',
'NDUFA10',
'NDUFA11',
'PRKAG2',
'PRKAG3',
'PIK3CD',
'PRKAG1',
'INS',
'COX5B',
'PIK3CG',
'IKBKB',
'MAPK9',
'MAPK8',
'RAC1',
'BID',
'MLXIP'],
"Alzheimer's disease Homo sapiens hsa05010": ['BAD',
'SDHD',
'GRIN2D',
'COX7B2',
'SDHB',
'GRIN2C',
'SDHC',
'GRIN1',
'ERN1',
'SDHA',
'FAS',
'UQCRQ',
'UQCRC2',
'UQCRC1',
'CALM2',
'CALM3',
'CALM1',
'APP',
'CALML6',
'NDUFB11',
'LRP1',
'NDUFB10',
'ATP5A1',
'UQCR10',
'CALML3',
'TNF',
'CALML5',
'UQCR11',
'COX6A2',
'NDUFC2-KCTD14',
'COX6A1',
'APBB1',
'CAPN1',
'CAPN2',
'NDUFV3',
'NCSTN',
'NDUFV2',
'SNCA',
'NDUFV1',
'COX8A',
'COX8C',
'COX7A2L',
'BACE1',
'BACE2',
'GNAQ',
'ATF6',
'ATP8',
'UQCRB',
'LPL',
'ATP6',
'CACNA1C',
'PSEN1',
'ATP5C1',
'CACNA1D',
'PSEN2',
'COX7A1',
'CACNA1F',
'COX7A2',
'UQCRH',
'PPP3R1',
'PPP3R2',
'GRIN2B',
'GRIN2A',
'CACNA1S',
'COX3',
'APOE',
'COX2',
'COX1',
'CYC1',
'PSENEN',
'APAF1',
'EIF2AK3',
'NDUFC2',
'NDUFC1',
'ATP5F1',
'COX6C',
'TNFRSF1A',
'IL1B',
'MAPT',
'NDUFS8',
'CDK5',
'NDUFS7',
'NDUFS6',
'NDUFS5',
'NDUFS4',
'NDUFS3',
'CYCS',
'NDUFS2',
'NDUFS1',
'CYTB',
'GSK3B',
'COX7C',
'NDUFB9',
'COX7B',
'NDUFB8',
'NDUFB7',
'NDUFB6',
'COX4I2',
'NDUFB5',
'NDUFB4',
'ITPR2',
'IDE',
'NDUFB3',
'ITPR3',
'NDUFB2',
'ATP5J',
'NDUFB1',
'ATP5O',
'ITPR1',
'PPP3CA',
'APH1B',
'ATP5D',
'PPP3CB',
'APH1A',
'PPP3CC',
'CASP8',
'ATP5B',
'CASP9',
'CASP12',
'ATP5H',
'CASP7',
'ATP5E',
'UQCRFS1',
'CASP3',
'COX4I1',
'FADD',
'NAE1',
'NDUFA9',
'NDUFA8',
'NDUFA7',
'NDUFA6',
'MME',
'NDUFA5',
'NDUFA4',
'NDUFA3',
'NDUFA2',
'NDUFA1',
'ADAM10',
'COX6B1',
'UQCRHL',
'COX6B2',
'PLCB4',
'ADAM17',
'NDUFAB1',
'NDUFA4L2',
'PLCB2',
'CDK5R1',
'PLCB3',
'GAPDH',
'PLCB1',
'RYR3',
'COX5A',
'NDUFA12',
'NDUFA13',
'NDUFA10',
'NDUFA11',
'ATP2A3',
'ATP2A2',
'ATP2A1',
'ATP5G3',
'ATP5G2',
'COX5B',
'HSD17B10',
'ATP5G1',
'MAPK3',
'MAPK1',
'NOS1',
'BID'],
'Oxidative phosphorylation Homo sapiens hsa00190': ['ATP6V1E1',
'PPA1',
'SDHD',
'COX7B2',
'SDHB',
'SDHC',
'SDHA',
'PPA2',
'UQCRQ',
'UQCRC2',
'UQCRC1',
'ATP6V0D1',
'NDUFB11',
'NDUFB10',
'ATP5A1',
'UQCR10',
'UQCR11',
'COX6A2',
'NDUFC2-KCTD14',
'COX6A1',
'ATP5J2',
'NDUFV3',
'ATP6V1E2',
'NDUFV2',
'NDUFV1',
'COX8A',
'ATP6V0C',
'COX8C',
'ATP6V0B',
'ATP6AP1',
'COX7A2L',
'ATP4B',
'ATP4A',
'ND2',
'ND1',
'ND4',
'ND3',
'ND6',
'ATP6V1B1',
'ND5',
'ATP6V1B2',
'ATP6V1A',
'ATP6V1D',
'ATP8',
'COX17',
'UQCRB',
'ATP6',
'ATP5C1',
'COX7A1',
'ATP12A',
'COX7A2',
'UQCRH',
'COX3',
'ATP6V0A4',
'COX15',
'COX2',
'COX1',
'CYC1',
'ATP6V1F',
'ATP6V1C1',
'COX11',
'ATP6V0A1',
'ATP6V1H',
'ATP6V1C2',
'COX10',
'ATP6V0A2',
'NDUFC2',
'NDUFC1',
'ATP5F1',
'COX6C',
'NDUFS8',
'NDUFS7',
'NDUFS6',
'NDUFS5',
'NDUFS4',
'NDUFS3',
'NDUFS2',
'NDUFS1',
'CYTB',
'COX7C',
'NDUFB9',
'COX7B',
'NDUFB8',
'NDUFB7',
'NDUFB6',
'COX4I2',
'NDUFB5',
'NDUFB4',
'NDUFB3',
'ATP5L',
'NDUFB2',
'ATP5J',
'NDUFB1',
'ATP5I',
'ATP5O',
'ATP5D',
'ATP5B',
'ATP5H',
'ATP5E',
'LHPP',
'UQCRFS1',
'COX4I1',
'NDUFA9',
'ATP6V1G1',
'NDUFA8',
'ATP6V0E1',
'ATP6V1G2',
'NDUFA7',
'ATP6V1G3',
'ATP6V0E2',
'NDUFA6',
'NDUFA5',
'NDUFA4',
'NDUFA3',
'NDUFA2',
'NDUFA1',
'ND4L',
'COX6B1',
'UQCRHL',
'COX6B2',
'NDUFAB1',
'NDUFA4L2',
'ATP6V0D2',
'COX5A',
'NDUFA12',
'NDUFA13',
'NDUFA10',
'NDUFA11',
'TCIRG1',
'ATP5G3',
'ATP5G2',
'COX5B',
'ATP5G1'],
"Parkinson's disease Homo sapiens hsa05012": ['SDHD',
'COX7B2',
'SDHB',
'SDHC',
'SDHA',
'PINK1',
'UQCRQ',
'UQCRC2',
'SLC25A31',
'UQCRC1',
'PPIF',
'PARK2',
'NDUFB11',
'NDUFB10',
'ADCY5',
'ATP5A1',
'UQCR10',
'PARK7',
'UQCR11',
'COX6A2',
'UBE2L6',
'NDUFC2-KCTD14',
'UBE2L3',
'COX6A1',
'NDUFV3',
'NDUFV2',
'SNCA',
'NDUFV1',
'COX8A',
'COX8C',
'COX7A2L',
'GNAL',
'ND2',
'ND1',
'UBA1',
'ND4',
'ND3',
'ND6',
'ND5',
'ATP8',
'UQCRB',
'ATP6',
'HTRA2',
'ATP5C1',
'COX7A1',
'SLC6A3',
'COX7A2',
'UBE2J1',
'UBE2J2',
'UQCRH',
'PRKACG',
'UBB',
'COX3',
'COX2',
'COX1',
'PRKACB',
'CYC1',
'PRKACA',
'APAF1',
'UBE2G2',
'NDUFC2',
'NDUFC1',
'SEPT5',
'UBE2G1',
'ATP5F1',
'COX6C',
'TH',
'NDUFS8',
'NDUFS7',
'NDUFS6',
'ADORA2A',
'NDUFS5',
'NDUFS4',
'NDUFS3',
'CYCS',
'NDUFS2',
'NDUFS1',
'CYTB',
'COX7C',
'NDUFB9',
'SLC25A4',
'COX7B',
'NDUFB8',
'NDUFB7',
'NDUFB6',
'UBA7',
'COX4I2',
'NDUFB5',
'NDUFB4',
'LRRK2',
'NDUFB3',
'NDUFB2',
'ATP5J',
'NDUFB1',
'ATP5O',
'ATP5D',
'ATP5B',
'CASP9',
'UCHL1',
'ATP5H',
'ATP5E',
'UQCRFS1',
'CASP3',
'COX4I1',
'DRD1',
'DRD2',
'SLC18A1',
'SLC18A2',
'NDUFA9',
'NDUFA8',
'GPR37',
'NDUFA7',
'NDUFA6',
'NDUFA5',
'NDUFA4',
'NDUFA3',
'NDUFA2',
'NDUFA1',
'ND4L',
'COX6B1',
'UQCRHL',
'COX6B2',
'NDUFAB1',
'NDUFA4L2',
'VDAC3',
'VDAC2',
'VDAC1',
'SLC25A6',
'SLC25A5',
'COX5A',
'NDUFA12',
'NDUFA13',
'NDUFA10',
'NDUFA11',
'ATP5G3',
'GNAI1',
'ATP5G2',
'COX5B',
'GNAI2',
'ATP5G1',
'GNAI3',
'SNCAIP'],
"Huntington's disease Homo sapiens hsa05016": ['POLR2J2',
'POLR2J3',
'TBPL1',
'UQCRC2',
'TBPL2',
'BAX',
'UQCRC1',
'TFAM',
'TP53',
'ATP5A1',
'UQCR10',
'UQCR11',
'CREB3L1',
'CREB3L4',
'CREB3L2',
'CREB3L3',
'AP2S1',
'PPARGC1A',
'DNAH14',
'CREBBP',
'COX8A',
'DNAH12',
'COX8C',
'DNAH11',
'DNAH17',
'COX7A2L',
'DNAH10',
'RCOR1',
'ATP5C1',
'DNALI1',
'GRIN2B',
'COX3',
'COX2',
'COX1',
'COX6C',
'HAP1',
'COX7C',
'COX7B',
'CLTC',
'CLTB',
'CLTA',
'BBC3',
'CLTCL1',
'AP2B1',
'COX6B1',
'COX6B2',
'PLCB4',
'NDUFAB1',
'NDUFA4L2',
'PPARG',
'PLCB2',
'PLCB3',
'PLCB1',
'HIP1',
'COX5A',
'NDUFA12',
'NDUFA13',
'NDUFA10',
'HTT',
'NDUFA11',
'AP2A2',
'AP2A1',
'COX5B',
'EP300',
'SDHD',
'COX7B2',
'SDHB',
'SDHC',
'GRIN1',
'SDHA',
'UQCRQ',
'SLC25A31',
'PPIF',
'NDUFB11',
'NDUFB10',
'UCP1',
'COX6A2',
'NDUFC2-KCTD14',
'COX6A1',
'NDUFV3',
'NDUFV2',
'NDUFV1',
'CREB3',
'CREB1',
'DLG4',
'GNAQ',
'TAF4B',
'DNAL1',
'DNAL4',
'CREB5',
'ATP8',
'UQCRB',
'ATP6',
'COX7A1',
'COX7A2',
'UQCRH',
'TGM2',
'CYC1',
'AP2M1',
'GPX1',
'APAF1',
'BDNF',
'NDUFC2',
'NDUFC1',
'ATP5F1',
'SP1',
'NDUFS8',
'NDUFS7',
'NDUFS6',
'NDUFS5',
'NDUFS4',
'NDUFS3',
'CYCS',
'NDUFS2',
'NDUFS1',
'CYTB',
'DNAH5',
'NDUFB9',
'DNAH2',
'SLC25A4',
'NDUFB8',
'DNAH3',
'NDUFB7',
'DNAH8',
'NDUFB6',
'DNAH9',
'COX4I2',
'NDUFB5',
'DNAH6',
'NDUFB4',
'DNAH7',
'NDUFB3',
'NDUFB2',
'ATP5J',
'NDUFB1',
'NRF1',
'ATP5O',
'ITPR1',
'ATP5D',
'CASP8',
'ATP5B',
'CASP9',
'ATP5H',
'ATP5E',
'UQCRFS1',
'CASP3',
'COX4I1',
'DNAI1',
'DNAI2',
'TBP',
'NDUFA9',
'NDUFA8',
'NDUFA7',
'NDUFA6',
'NDUFA5',
'NDUFA4',
'NDUFA3',
'NDUFA2',
'NDUFA1',
'SOD1',
'UQCRHL',
'SOD2',
'REST',
'VDAC3',
'VDAC2',
'VDAC1',
'SLC25A6',
'TAF4',
'DNAH1',
'SLC25A5',
'HDAC1',
'HDAC2',
'DCTN2',
'DCTN4',
'DCTN1',
'ATP5G3',
'ATP5G2',
'ATP5G1',
'GRM5',
'POLR2A',
'POLR2B',
'POLR2C',
'SIN3A',
'POLR2D',
'POLR2E',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'POLR2J',
'POLR2K',
'IFT57',
'POLR2L'],
'Metabolic pathways Homo sapiens hsa01100': ['B3GALNT1',
'POLR2J2',
'POLR2J3',
'CKMT1B',
'CKMT1A',
'UPB1',
'CYP2C9',
'CYP2C8',
'MTHFD2',
'IDNK',
'MTHFD1',
'UQCRC2',
'UQCRC1',
'IDO1',
'IDO2',
'MTMR1',
'MTMR2',
'PGAP1',
'MTMR3',
'PDXK',
'MTMR4',
'PON1',
'PON3',
'PON2',
'ATP5A1',
'MTMR6',
'PDXP',
'MTMR7',
'MTMR8',
'UGP2',
'GMDS',
'SDS',
'PMM2',
'CYP4F2',
'PMM1',
'ATP6AP1',
'CYP4F3',
'CYP4F8',
'DHFR',
'UCK2',
'CYP2A6',
'UCK1',
'FASN',
'QARS',
'ADSSL1',
'LALBA',
'HPD',
'ACSBG2',
'ACSBG1',
'TSTA3',
'UXS1',
'PLA2G3',
'PLA2G5',
'ATP5C1',
'PLA2G6',
'LIPC',
'PLA2G7',
'IL4I1',
'LIPG',
'LIPF',
'CYP2B6',
'TDO2',
'NAPRT',
'SCP2',
'PIP5K1A',
'PIP5K1B',
'COX3',
'LTA4H',
'PIP5K1C',
'COX2',
'COX1',
'XYLB',
'SPHK2',
'SPHK1',
'LOC102724560',
'CS',
'PIGC',
'PIGF',
'BHMT',
'PIGB',
'DPYD',
'PIGA',
'PIGL',
'PAFAH1B1',
'PI4KB',
'PIGK',
'PI4KA',
'PIGN',
'PIGM',
'PIGH',
'PAFAH1B3',
'PAFAH1B2',
'FAXDC2',
'ACAT1',
'ECHS1',
'ACAT2',
'EXTL1',
'HLCS',
'ATIC',
'UGT8',
'EXTL3',
'EXTL2',
'HAO2',
'HAO1',
'HSD11B1',
'AADAT',
'ARG1',
'MDH2',
'DGAT2',
'ARG2',
'PGAM1',
'PKLR',
'DGAT1',
'PGAM2',
'COX6B1',
'COX6B2',
'BDH2',
'BDH1',
'ETNK2',
'AGPS',
'CYP21A2',
'ETNK1',
'JMJD7-PLA2G4B',
'PGAM4',
'DLD',
'CYP2E1',
'LOC390877',
'PIGT',
'OAT',
'PIGS',
'FH',
'PIGV',
'PIGU',
'PIGP',
'HEXA',
'PIGO',
'DPYS',
'QPRT',
'PIGQ',
'HEXB',
'MTMR14',
'PIGX',
'PIGW',
'PTGS1',
'PTGS2',
'PIGY',
'NUDT12',
'SMPD4',
'NDST3',
'SMPD3',
'NDST2',
'ADAM29',
'NDST1',
'NSDHL',
'SMPD2',
'SMPD1',
'NDST4',
'MLYCD',
'CEPT1',
'MDH1',
'ENOPH1',
'GK',
'UCKL1',
'UQCRQ',
'UGT1A10',
'IDUA',
'AKR1D1',
'ODC1',
'DLST',
'NTPCR',
'HPGDS',
'PIPOX',
'CERS4',
'CERS5',
'CERS6',
'GOT2',
'PCYT2',
'GOT1',
'UROS',
'B3GALT5',
'B3GALT4',
'B3GALT6',
'ACLY',
'MINPP1',
'NT5C3B',
'DDOST',
'NT5C3A',
'LOC102724788',
'TBXAS1',
'HPSE',
'SMS',
'AGXT2',
'ST6GALNAC4',
'BCAT2',
'ST6GALNAC5',
'BCAT1',
'CERS1',
'ST6GALNAC6',
'CERS2',
'CERS3',
'SLC27A5',
'ATP8',
'UQCRB',
'ATP6',
'SAT1',
'CYP2C19',
'SAT2',
'CYP2C18',
'CYP19A1',
'UQCRH',
'B3GALT1',
'AMDHD1',
'UROD',
'HYI',
'B3GALT2',
'FUK',
'KL',
'GFPT1',
'UGT2A1',
'GFPT2',
'NDUFC2',
'NDUFC1',
'G6PC2',
'NT5C1A',
'G6PC3',
'PCCB',
'PCCA',
'IMPAD1',
'RRM2B',
'NT5C1B',
'ACO2',
'DCTPP1',
'PIK3C3',
'ACO1',
'ST6GALNAC1',
'NDUFB9',
'ST6GALNAC3',
'NDUFB8',
'NDUFB7',
'NDUFB6',
'SHMT2',
'COX4I2',
'NDUFB5',
'SHMT1',
'NDUFB4',
'NDUFB3',
'ATP5L',
'GMPS',
'NDUFB2',
'ATP5J',
'NDUFB1',
'APIP',
'UAP1',
'ATP5I',
'ATP5O',
'ATP5D',
'ZNRD1',
'ATP5B',
'ALAD',
'KDSR',
'DSE',
'PMVK',
'ATP5H',
'SPR',
'RDH12',
'RDH11',
'RDH10',
'ATP5E',
'PGK2',
'RDH16',
'ME1',
'PGK1',
'COX4I1',
'UGT2A3',
'B4GALNT1',
'ME3',
'UGT2A2',
'NADK',
'UGT2B11',
'NDUFA9',
'UGT2B10',
'NDUFA8',
'NDUFA7',
'MMAB',
'NDUFA6',
'UGT2B15',
'NDUFA5',
'NDUFA4',
'UGT2B17',
'NDUFA3',
'MBOAT2',
'NDUFA2',
'NDUFA1',
'DHODH',
'MBOAT1',
'CECR1',
'NAGK',
'SUCLA2',
'NAGS',
'UGT2B4',
'GAPDH',
'AGXT',
'UGT2B7',
'PRPS2',
'ALAS2',
'DMGDH',
'ALAS1',
'PRPS1',
'UGT2B28',
'UROC1',
'SRM',
'HSD17B12',
'HSD17B10',
'CKMT2',
'GANAB',
'PGLS',
'PGM3',
'UPP2',
'UPP1',
'PGM2',
'PGM1',
'DUT',
'ATP6V1E1',
'PHYKPL',
'MOGS',
'PISD',
'GSTZ1',
'PC',
'LAP3',
'UPRT',
'AHCYL1',
'CES1',
'AHCYL2',
'C1GALT1C1',
'ATP6V1E2',
'ARSB',
'COX8A',
'ALG9',
'ST6GAL2',
'COX8C',
'ST8SIA1',
'PLA2G4E',
'ALG8',
'ST6GAL1',
'PLA2G4F',
'TGDS',
'ALG5',
'PLA2G4C',
'ALG6',
'PLA2G4D',
'ALG3',
'TALDO1',
'PLA2G4A',
'PLA2G4B',
'ALG1',
'ALG2',
'EXT1',
'BTD',
'EXT2',
'ACER2',
'ACER1',
'NT5C1B-RDH14',
'LDHAL6A',
'GCDH',
'LDHAL6B',
'PEMT',
'ATP6V1B1',
'ATP6V1B2',
'HYKK',
'ANPEP',
'SI',
'PPAT',
'RIMKLB',
'ATP6V1C1',
'NADK2',
'ATP6V1C2',
'RIMKLA',
'ACAD8',
'AASS',
'AKR1A1',
'COX6C',
'BST1',
'TH',
'ALDH6A1',
'HMGCLL1',
'COX7C',
'HIBADH',
'COX7B',
'MOGAT3',
'ACY1',
'GPAA1',
'PPCS',
'KHK',
'ACACB',
'ACACA',
'THTPA',
'PGS1',
'AANAT',
'IDS',
'ST8SIA5',
'CD38',
'PHGDH',
'PCK2',
'PCK1',
'ATP6V1G1',
'ATP6V1G2',
'ATP6V1G3',
'GCH1',
'GAD2',
'GAA',
'GAD1',
'AKR1C4',
'AKR1C3',
'ND4L',
'CYP8B1',
'APRT',
'GPAM',
'NDUFAB1',
'PNPLA2',
'PNPLA3',
'AHCY',
'COX5A',
'GBA',
'AKR1B1',
'COX5B',
'NANP',
'CYP17A1',
'SPTLC1',
'NANS',
'SPTLC2',
'HYAL1',
'ACADM',
'SPTLC3',
'HYAL2',
'ACADL',
'ENPP1',
'HYAL3',
'HYAL4',
'ENPP3',
'MGAT5',
'MGAT2',
'XDH',
'MGAT3',
'ENPP7',
'MGAT1',
'ACADS',
'REV3L',
'G6PC',
'HSD3B7',
'G6PD',
'HSD3B1',
'HSD3B2',
'SDHD',
'SDHB',
'SDHC',
'GCK',
'SDHA',
'ALDH4A1',
'CYP24A1',
'POLE2',
'POLE3',
'POLE4',
'DEGS2',
'OTC',
'DEGS1',
'ALLC',
'DPAGT1',
'INPP1',
'GDA',
'MPI',
'NDUFB11',
'NDUFB10',
'HSD17B4',
'HSD17B6',
'CPOX',
'HSD17B7',
'HSD17B8',
'COX6A2',
'COX6A1',
'HSD17B1',
'HSD17B2',
'HSD17B3',
'NDUFV3',
'NDUFV2',
'NDUFV1',
'GGT6',
'PCYT1A',
'FDPS',
'GGT5',
'MGAM',
'GGT7',
'PCYT1B',
'DOLK',
'NAT1',
'KMO',
'QDPR',
'GCLC',
'NAT2',
'STT3B',
'STT3A',
'POLG2',
'GCLM',
'COX17',
'PLB1',
'EBP',
'NME1-NME2',
'NMRK2',
'CYP11A1',
'NMRK1',
'COX15',
'ACAA2',
'CYC1',
'A4GALT',
'GGT1',
'PRODH',
'ACAA1',
'COX11',
'COX10',
'GALNT8',
'BCKDHB',
'GALNT7',
'BCKDHA',
'GALNT6',
'PLA2G2E',
'PAICS',
'GALNT5',
'PLA2G2F',
'GALNT4',
'PLA2G2C',
'GALNT3',
'PLA2G2D',
'GALNT2',
'CYP4A11',
'PLA2G2A',
'GALNT1',
'GALK1',
'POLA1',
'POLA2',
'CYP26A1',
'ALPP',
'NDUFS8',
'ACOX3',
'CPS1',
'CHPT1',
'ACOX2',
'NDUFS7',
'NDUFS6',
'ACOX1',
'NDUFS5',
'ALPL',
'NDUFS4',
'NDUFS3',
'CYCS',
'NDUFS2',
'NDUFS1',
'FBP1',
'ALPI',
'NAT8L',
'FBP2',
'PNLIPRP2',
'AGPAT6',
'PNLIPRP3',
'NNMT',
'PNLIPRP1',
'AGPAT9',
'TAT',
'ACMSD',
'ACSM2A',
'ACSM2B',
'FUT1',
'MTR',
'AGPAT1',
'FUT3',
'AGPAT2',
'PLD2',
'FUT2',
'AGPAT3',
'PLD1',
'FUT5',
'AGPAT4',
'PLD4',
'FUT4',
'AGPAT5',
'PLD3',
'NT5C2',
'FUT7',
'FUT6',
'FUT9',
'FUT8',
'CYP26B1',
'UQCRFS1',
'MAN1A2',
'MAN1A1',
'PRPS1L1',
'GALNT9',
'FAHD1',
'RRM2',
'CAD',
'RRM1',
'MUT',
'QRSL1',
'UQCRHL',
'PLA2G16',
'GALC',
'GLB1',
'RPIA',
'GALE',
'MAT1A',
'CYP26C1',
'PLA2G10',
'CHDH',
'SARDH',
'MAN1B1',
'GALM',
'MVD',
'MVK',
'LAMA3',
'PLA2G1B',
'LAMA5',
'TREH',
'HMGCR',
'MSMO1',
'GK2',
'HMGCL',
'POLD4',
'CBS',
'MAT2B',
'MAT2A',
'OGDHL',
'POLD1',
'POLD2',
'POLD3',
'MAN1C1',
'EARS2',
'GAMT',
'MECR',
'ACOT8',
'GLYCTK',
'GLCE',
'GANC',
'GALNS',
'MTAP',
'POLR3A',
'POLR3B',
'HMBS',
'POLR3C',
'POLR3D',
'POLR3F',
'POLR3G',
'CYP1A2',
'PLCD1',
'POLR3H',
'CYP1A1',
'ACOT2',
'ACOT1',
'ALG10B',
'PLCD4',
'POLR3K',
'PI4K2B',
'CDA',
'PI4K2A',
'PLCD3',
'ACOT4',
'GALT',
'ASAH2',
'SGMS2',
'SGMS1',
'XYLT1',
'XYLT2',
'GLS',
'ABAT',
'PPOX',
'ASAH1',
'ALOX5',
'ST3GAL5',
'PLCE1',
'ST3GAL6',
'ST3GAL1',
'ST3GAL2',
'ST3GAL3',
'FDFT1',
'ST3GAL4',
'CHIA',
'EPT1',
'MTHFR',
'CEL',
'MTHFS',
'MCAT',
'PAFAH2',
'SQLE',
'HOGA1',
'PPT2',
'ITPA',
'PPT1',
'HPRT1',
'GNE',
'OGDH',
'LIPT2',
'PNMT',
'GLDC',
'GNS',
'ENO1',
'ENO2',
'EPRS',
'ENO3',
'ABO',
'ADH6',
'ADH7',
'ADH4',
'GCSH',
'ADH5',
'PRDX6',
'PLCG1',
'DHRS4L2',
'PLCG2',
'DHRS4L1',
'LIPT1',
'PDHA2',
'TPI1',
'PDHA1',
'CHKB',
'CHKA',
'ITPK1',
'GLUD1',
'ITPKC',
'GLUD2',
'ADI1',
'ITPKA',
'CYP11B2',
'PAH',
'ITPKB',
'CYP11B1',
'GALNTL6',
'GALNTL5',
'GART',
'MOCS1',
'MOCS2',
'MGLL',
'ADA',
'GPI',
'TPH2',
'TPH1',
'RPN1',
'RPN2',
'ADK',
'ADO',
'GPT',
'CSAD',
'SDSL',
'LDHC',
'LDHB',
'LDHA',
'RFK',
'TK1',
'PNPO',
'TK2',
'TPK1',
'GATB',
'GATC',
'NMNAT3',
'FAM213B',
'AGMAT',
'DHRS3',
'DHRS4',
'BAAT',
'HADHB',
'PLCB4',
'DHRS9',
'GATM',
'NMNAT2',
'NMNAT1',
'HADHA',
'LPCAT4',
'IVD',
'NDUFA4L2',
'RGN',
'PLCB2',
'PLCB3',
'TKT',
'PLCB1',
'PFAS',
'NDUFA12',
'NDUFA13',
'PYGB',
'GCNT1',
'NDUFA10',
'GCNT2',
'NDUFA11',
'PYGL',
'LPCAT2',
'LPCAT1',
'PYGM',
'MCEE',
'IMPA1',
'NAMPT',
'IMPA2',
'GCNT3',
'CKB',
'GPAT2',
'GCNT4',
'CSGALNACT2',
'CSGALNACT1',
'AOC2',
'AOC3',
'AGK',
'CKM',
'AOC1',
'AGL',
'IPMK',
'GSS',
'GPT2',
'ALPPL2',
'PSAT1',
'GAPDHS',
'DHCR7',
'DGKH',
'DGKG',
'RPEL1',
'ACSS3',
'DGKE',
'DGKD',
'CHPF',
'TUSC3',
'DGKB',
'DGKA',
'PAPSS1',
'LCLAT1',
'NDUFC2-KCTD14',
'PAPSS2',
'SC5D',
'ACSS2',
'ACSS1',
'CHPF2',
'PGD',
'DGKZ',
'COASY',
'SYNJ2',
'SYNJ1',
'DGKQ',
'PGP',
'ND2',
'ND1',
'ND4',
'DNMT1',
'DGKK',
'ND3',
'ND6',
'DGKI',
'ND5',
'ASMT',
'AK1',
'AK2',
'AK4',
'AK5',
'AK6',
'AK7',
'AK8',
'TM7SF2',
'AK9',
'TPO',
'TRIT1',
'HMGCS2',
'POLR3GL',
'HMGCS1',
'PLCH1',
'DNMT3A',
'DNMT3B',
'ASNS',
'DHCR24',
'SORD',
'PLCH2',
'CYTB',
'GAL3ST1',
'FECH',
'IPPK',
'AMD1',
'ST20-MTHFS',
'MRI1',
'GADL1',
'CYP3A4',
'CYP3A5',
'CYP3A7',
'MTM1',
'MGAT5B',
'PIP5KL1',
'PLA2G12A',
'PLA2G12B',
'CYP51A1',
'IDH3G',
'ADSL',
'UGT1A1',
'AMT',
'GGPS1',
'BPGM',
'MGAT4D',
'PKM',
'CHIT1',
'PFKM',
'PFKL',
'PPAP2A',
'IMPDH1',
'POLR1A',
'MGAT4A',
'IMPDH2',
'POLR1B',
'TST',
'MGAT4B',
'DAD1',
'PPAP2C',
'POLR1C',
'MGAT4C',
'PPAP2B',
'POLR1D',
'POLR1E',
'ALDH9A1',
'ASPA',
'LCT',
'PFKP',
'TYRP1',
'ADPGK',
'RPE',
'TCIRG1',
'PIK3C2G',
'PIK3C2B',
'PIK3C2A',
'FTCD',
'POLR2A',
'POLR2B',
'DHFRL1',
'NAGLU',
'POLR2C',
'POLR2D',
'POLR2E',
'POLR2F',
'UGT1A6',
'POLR2G',
'UGT1A5',
'FLAD1',
'POLR2H',
'UGT1A4',
'POLR2I',
'UGT1A3',
'ADSS',
'POLR2J',
'BCO1',
'POLR2K',
'UGT1A9',
'IDH3A',
'POLR2L',
'UGT1A8',
'IDH3B',
'UGT1A7',
'ACSL3',
'PDHX',
'ACSL1',
'OXSM',
'ACSL6',
'ACSL5',
'ACSL4',
'ETNPPL',
'ASS1',
'CYP2U1',
'MTHFD2L',
'CTH',
'SUCLG2',
'SUCLG1',
'CDO1',
'PANK3',
'GLS2',
'PANK4',
'ATP6V0D1',
'PANK1',
'CMAS',
'PANK2',
'ADH1C',
'ADH1B',
'ADH1A',
'PDHB',
'UQCR10',
'ALOX12B',
'HPSE2',
'UQCR11',
'PNP',
'NFS1',
'SEPHS1',
'MTHFD1L',
'SEPHS2',
'PTGDS',
'BHMT2',
'ACADSB',
'CMBL',
'ALOX15B',
'GBGT1',
'INPP4B',
'CYP27A1',
'ALDH7A1',
'WBSCR17',
'INPP4A',
'CYP2S1',
'PTGES',
...],
'Amyotrophic lateral sclerosis (ALS) Homo sapiens hsa05014': ['GPX1',
'BAD',
'APAF1',
'GRIN2D',
'GRIN2C',
'MAPK13',
'TNFRSF1A',
'GRIN1',
'TNFRSF1B',
'MAPK14',
'TOMM40L',
'MAPK11',
'MAPK12',
'CCS',
'BCL2',
'BAX',
'CYCS',
'TP53',
'SLC1A2',
'TNF',
'PPP3CA',
'PPP3CB',
'PPP3CC',
'CASP9',
'CASP12',
'CASP3',
'CASP1',
'PRPH',
'MAP3K5',
'MAP2K3',
'DAXX',
'SOD1',
'CAT',
'ALS2',
'BCL2L1',
'RAB5A',
'GRIA2',
'TOMM40',
'GRIA1',
'DERL1',
'PPP3R1',
'PPP3R2',
'GRIN2B',
'GRIN2A',
'NEFL',
'NEFM',
'RAC1',
'NOS1',
'NEFH',
'BID',
'MAP2K6'],
'Nicotine addiction Homo sapiens hsa05033': ['GABRA3',
'GABRA2',
'GABRQ',
'CHRNB2',
'GABRA1',
'GABRP',
'GABRA6',
'SLC32A1',
'GABRA5',
'GABRA4',
'GABRG1',
'GRIN2D',
'GRIN2C',
'GABRG3',
'GRIN1',
'GABRG2',
'GRIN3A',
'GRIN3B',
'GRIA2',
'GABRB3',
'GRIA3',
'GABRB2',
'CHRNA4',
'GABRB1',
'GRIA1',
'CHRNA6',
'CACNA1A',
'CHRNA7',
'CACNA1B',
'GABRR3',
'GABRR2',
'GRIN2B',
'GABRR1',
'GRIN2A',
'SLC17A6',
'SLC17A7',
'SLC17A8',
'GABRE',
'GABRD',
'GRIA4'],
'Neuroactive ligand-receptor interaction Homo sapiens hsa04080': ['TRHR',
'TAAR9',
'TAAR8',
'TAAR5',
'TAAR6',
'TAAR1',
'GRIN2D',
'TAAR2',
'GRIN2C',
'HTR5A',
'GRIN3A',
'GRIN3B',
'LPAR6',
'LEP',
'AGTR2',
'AGTR1',
'VIPR2',
'PRSS2',
'PRSS1',
'VIPR1',
'C3AR1',
'NTSR1',
'GPR156',
'PRSS3',
'PTGDR',
'NTSR2',
'PARD3',
'NMBR',
'AVPR1A',
'AVPR1B',
'MC1R',
'CCKBR',
'PTGFR',
'CRHR1',
'NPFFR1',
'NPFFR2',
'OXTR',
'LHB',
'LPAR2',
'LPAR3',
'LPAR4',
'RXFP1',
'ADCYAP1R1',
'RXFP2',
'GRPR',
'HTR6',
'CRHR2',
'RXFP3',
'LPAR1',
'RXFP4',
'HTR4',
'GHRHR',
'HTR7',
'GRIN2B',
'GRIN2A',
'GALR3',
'GALR2',
'GALR1',
'CGA',
'GABRA3',
'GABRA2',
'GABBR2',
'GABRA1',
'GABBR1',
'GABRA6',
'GABRA5',
'GABRA4',
'FSHB',
'TACR3',
'TACR1',
'TACR2',
'MC3R',
'FSHR',
'GABRB3',
'GABRB2',
'GIPR',
'GABRB1',
'OPRD1',
'PRL',
'FPR2',
'GRIK4',
'ADRB1',
'FPR1',
'GRIK5',
'ADRB2',
'PTH1R',
'GRIK2',
'ADRB3',
'FPR3',
'GRIK3',
'GRIK1',
'BRS3',
'GABRR3',
'MC2R',
'GABRR2',
'GABRR1',
'CCKAR',
'GNRHR',
'CTSG',
'P2RY13',
'P2RY14',
'P2RY11',
'GPR35',
'GCGR',
'F2',
'SCTR',
'PTH2R',
'P2RY10',
'MAS1',
'MC5R',
'F2RL1',
'F2RL2',
'F2RL3',
'PTGER1',
'PTGER2',
'PTAFR',
'PTGER3',
'PTGER4',
'GLRA1',
'CHRND',
'CHRNE',
'GLRA2',
'GLRA3',
'MC4R',
'CHRNG',
'CHRNA10',
'TSPO',
'GABRE',
'GABRD',
'CHRNB3',
'GABRQ',
'CHRNB2',
'PRLR',
'GABRP',
'CHRNB4',
'NPY1R',
'TRPV1',
'GPR50',
'GRIN1',
'MTNR1B',
'MTNR1A',
'LTB4R2',
'APLNR',
'CHRNB1',
'CHRNA2',
'CHRM3',
'CHRNA1',
'CHRM4',
'CHRM1',
'CHRNA4',
'CHRM2',
'CHRNA3',
'CHRNA6',
'CHRNA5',
'CHRM5',
'CHRNA7',
'CHRNA9',
'CYSLTR2',
'CYSLTR1',
'S1PR2',
'ADORA3',
'KISS1R',
'S1PR1',
'S1PR4',
'S1PR3',
'ADORA1',
'S1PR5',
'GHSR',
'F2R',
'ADRA2C',
'ADRA2B',
'ADRA2A',
'NMUR2',
'NMUR1',
'GRIA2',
'GRIA3',
'CALCRL',
'GRIA1',
'C5AR1',
'CSH2',
'CSH1',
'MCHR1',
'GPR83',
'MCHR2',
'CALCR',
'LEPR',
'GRIA4',
'NPY5R',
'HTR1F',
'HTR1D',
'AVPR2',
'HTR1E',
'HTR1B',
'OPRM1',
'SSTR1',
'SSTR2',
'HTR1A',
'SSTR3',
'SSTR4',
'GH1',
'SSTR5',
'GH2',
'ADORA2B',
'ADORA2A',
'LTB4R',
'NPY4R',
'GLP1R',
'HTR2C',
'HTR2A',
'ADRA1D',
'OPRL1',
'HTR2B',
'ADRA1B',
'ADRA1A',
'GHR',
'P2RY8',
'HRH2',
'P2RY6',
'HRH1',
'HRH4',
'TBXA2R',
'NPBWR1',
'HRH3',
'P2RY4',
'NPBWR2',
'BDKRB1',
'P2RY2',
'P2RY1',
'BDKRB2',
'DRD1',
'DRD2',
'DRD3',
'DRD4',
'PRLHR',
'DRD5',
'LHCGR',
'GRID1',
'PTGIR',
'GRID2',
'UTS2R',
'GLP2R',
'GZMA',
'GABRG1',
'OPRK1',
'HCRTR1',
'GABRG3',
'GABRG2',
'HCRTR2',
'TSHR',
'P2RX7',
'P2RX6',
'P2RX5',
'P2RX4',
'GLRB',
'P2RX3',
'P2RX2',
'P2RX1',
'THRB',
'THRA',
'NPY2R',
'MLNR',
'PLG',
'NR3C1',
'GRM2',
'GRM1',
'GRM4',
'GRM3',
'EDNRA',
'LOC100996758',
'GRM6',
'EDNRB',
'GRM5',
'GRM8',
'CNR2',
'GRM7',
'CNR1',
'TSHB'],
'Taste transduction Homo sapiens hsa04742': ['GABRA3',
'TAS2R50',
'GABRA2',
'GABBR2',
'GABRA1',
'ENTPD2',
'GABBR1',
'TAS2R10',
'HTR1F',
'GABRA6',
'GABRA5',
'HTR1D',
'GABRA4',
'TAS2R13',
'HTR1E',
'TAS2R14',
'HTR1B',
'TAS2R16',
'HTR1A',
'GNG13',
'TAS2R19',
'SCNN1G',
'SCNN1B',
'TAS2R60',
'KCNK5',
'CHRM3',
'TAS2R8',
'TAS2R7',
'TAS2R40',
'HCN4',
'TAS2R41',
'TAS2R9',
'TAS2R42',
'TAS2R43',
'TAS2R45',
'TAS2R46',
'SCNN1A',
'ADCY4',
'ITPR3',
'PKD2L1',
'ADCY8',
'ADCY6',
'GNAT3',
'P2RY4',
'P2RY1',
'SCN3A',
'TAS2R1',
'TAS2R4',
'TAS2R3',
'ASIC2',
'TAS2R5',
'TAS2R30',
'TAS2R31',
'HTR3D',
'HTR3E',
'TAS2R38',
'HTR3B',
'TAS2R39',
'HTR3C',
'HTR3A',
'P2RX3',
'GNB3',
'P2RX2',
'PLCB2',
'SCN2A',
'TAS2R20',
'PDE1C',
'CACNA1A',
'PDE1B',
'PDE1A',
'CACNA1C',
'PKD1L3',
'GRM1',
'GRM4',
'PRKACG',
'CALHM1',
'SCN9A',
'TAS1R1',
'TAS1R3',
'TAS1R2',
'PRKACB',
'PRKACA',
'TRPM5'],
'Olfactory transduction Homo sapiens hsa04740': ['OR11G2',
'OR2L8',
'OR2L5',
'OR1J4',
'OR2L3',
'OR1J2',
'OR4P4',
'OR2L2',
'OR1J1',
'OR5R1',
'OR6T1',
'OR4K13',
'OR4K17',
'OR4K15',
'OR4K14',
'OR13J1',
'ADCY3',
'OR2K2',
'OR1I1',
'OR6S1',
'OR5M11',
'OR5M10',
'GNG7',
'OR8B12',
'OR10C1',
'OR4N5',
'OR2J3',
'OR4N4',
'OR2J2',
'OR5P3',
'OR4N2',
'OR5P2',
'OR13H1',
'OR14J1',
'OR8U9',
'OR7A10',
'OR8U8',
'OR1G1',
'OR4M2',
'OR4M1',
'OR6Q1',
'OR8U1',
'PRKACG',
'OR56B1',
'PRKACB',
'OR7A17',
'OR56B4',
'PRKACA',
'OR52A1',
'OR1N2',
'OR1N1',
'OR5V1',
'OR6X1',
'OR52A5',
'OR10H2',
'OR10H1',
'OR10H4',
'OR10H3',
'OR10H5',
'OR1M1',
'OR4S2',
'OR4S1',
'OR2AG1',
'OR2AG2',
'OR10G3',
'OR10G2',
'OR1L8',
'OR10G4',
'OR1L6',
'OR1L4',
'OR1L3',
'OR1L1',
'OR5T3',
'OR5T2',
'OR5T1',
'OR6V1',
'OR10G7',
'OR10G9',
'OR10G8',
'OR11H1',
'OR2M7',
'OR11H4',
'OR2M5',
'OR2M4',
'OR2M3',
'OR2M2',
'OR1K1',
'OR4Q3',
'SLC8A1',
'SLC8A2',
'SLC8A3',
'ADRBK2',
'ADRBK1',
'OR2AE1',
'OR11H6',
'OR14A16',
'OR5AS1',
'OR2T8',
'OR2T6',
'OR51T1',
'OR2T5',
'OR13C8',
'OR2T4',
'OR2T3',
'OR2T2',
'OR13C9',
'OR2T1',
'OR2L13',
'OR4X2',
'OR4X1',
'OR9A4',
'OR9A2',
'OR13C2',
'OR13C4',
'OR13C3',
'OR13C5',
'OR5AR1',
'OR2S2',
'OR1Q1',
'OR51S1',
'OR4A47',
'OR14C36',
'OR5B21',
'OR13A1',
'OR7E24',
'CNGB1',
'OR5W2',
'OR6Y1',
'OR51Q1',
'OR5B12',
'OR5AP2',
'OR5B17',
'OR6C70',
'OR14I1',
'OR6C76',
'OR6C75',
'OR6C74',
'OR13G1',
'OR7A5',
'OR56A1',
'OR10A3',
'OR10A2',
'OR56A5',
'OR10A5',
'OR56A4',
'OR10A4',
'OR56A3',
'OR10A7',
'OR10A6',
'OR6C65',
'OR13F1',
'OR8B8',
'OR2W3',
'OR2W1',
'OR12D2',
'CNGA2',
'OR8B4',
'CNGA3',
'OR8B3',
'OR6C68',
'CNGA4',
'OR8B2',
'OR12D3',
'PRKG2',
'PRKG1',
'OR5AU1',
'LOC102723532',
'OR51V1',
'OR2V2',
'OR2V1',
'OR8A1',
'OR11A1',
'SLC24A4',
'ARRB2',
'OR52W1',
'OR1S2',
'OR1S1',
'ARRB1',
'OR13D1',
'OR8H3',
'OR8H2',
'OR8H1',
'OR52M1',
'OR10V1',
'OR4C13',
'OR4C12',
'OR6C6',
'OR4C11',
'OR2AT4',
'CALM2',
'OR6C4',
'CALM3',
'OR8G5',
'OR6C3',
'OR5A2',
'OR4C16',
'OR6C2',
'OR5AK2',
'OR5A1',
'OR4C15',
'CALM1',
'OR6C1',
'OR8G2',
'OR8G1',
'OR9I1',
'CALML6',
'CALML3',
'CALML5',
'OR52L1',
'OR7D4',
'OR6B3',
'OR6B2',
'OR7D2',
'OR6B1',
'OR2A25',
'OR51I2',
'OR52K2',
'OR51I1',
'OR52K1',
'OR10T2',
'OR9G9',
'OR2A12',
'OR4D11',
'OR4D10',
'OR2Z1',
'OR6A2',
'OR9G4',
'OR7C2',
'OR7C1',
'OR2A14',
'OR9G1',
'OR52J3',
'PDE1C',
'PDE1B',
'PDE1A',
'OR10R2',
'OR10S1',
'PDE2A',
'OR2Y1',
'OR8D4',
'OR8D2',
'OR8D1',
'OR4D2',
'OR4D1',
'OR5F1',
'GNG13',
'OR10Z1',
'OR52R1',
'OR4A15',
'OR4C6',
'OR4A16',
'OR3A3',
'OR4C3',
'OR3A2',
'OR3A1',
'GUCY2D',
'OR8K5',
'OR8K3',
'OR8K1',
'OR4C46',
'OR4C45',
'OR5AN1',
'OR4B1',
'OR8J3',
'OR6F1',
'OR8J1',
'OR51M1',
'ANO2',
'OR10X1',
'OR4A5',
'OR7G3',
'OR5C1',
'OR7G2',
'OR8I2',
'OR7G1',
'OR9K2',
'OR2A42',
'OR52N2',
'OR51L1',
'OR52N1',
'OR52N5',
'OR52N4',
'OR10W1',
'OR5D18',
'OR5D13',
'OR5D16',
'OR5B3',
'OR5B2',
'OR5D14',
'OR2D3',
'OR2D2',
'OR1B1',
'OR52E4',
'OR5J2',
'OR52E2',
'OR5AC2',
'OR52E8',
'OR52E6',
'OR2C3',
'OR1A2',
'OR6K6',
'OR1A1',
'OR2C1',
'OR6K3',
'OR51B2',
'OR6K2',
'OR5I1',
'OR52D1',
'OR9Q2',
'OR9Q1',
'OR2AK2',
'OR51B6',
'OR51B5',
'OR51B4',
'OR2B6',
'OR4F6',
'OR5H6',
'OR4F5',
'OR2B3',
'OR4F4',
'OR2B2',
'OR10K2',
'OR4F3',
'OR5H2',
'OR51A2',
'OR5H1',
'OR10K1',
'GNAL',
'GNB1',
'OR51A4',
'OR2A7',
'OR2A5',
'OR2A4',
'OR51A7',
'OR2A2',
'OR2A1',
'OR10J1',
'OR4E2',
'OR10J3',
'OR52B2',
'OR10J5',
'OR11L1',
'RGS2',
'OR52B6',
'OR52B4',
'OR4D9',
'OR4D6',
'OR4D5',
'OR51G2',
'OR52I2',
'OR51G1',
'OR2H2',
'OR1F1',
'OR2H1',
'OR10Q1',
'OR4L1',
'OR6P1',
'OR52I1',
'OR2B11',
'OR2AP1',
'OR51F2',
'OR5M9',
'OR51F1',
'OR2G6',
'OR5M8',
'OR52H1',
'OR4K5',
'OR2G3',
'OR1E2',
'OR2G2',
'OR1E1',
'OR11H12',
'OR5M3',
'OR4K2',
'NCALD',
'OR4K1',
'OR5M1',
'OR10AG1',
'OR10P1',
'OR8S1',
'OR2T33',
'OR2T34',
'OR4F29',
'OR4F21',
'OR51E2',
'OR51E1',
'OR2T29',
'OR1D5',
'OR2T27',
'OR1D2',
'OR2F2',
'OR2F1',
'OR5L2',
'OR6N2',
'OR5L1',
'OR10AD1',
'OR6N1',
'OR4F17',
'OR4F16',
'OR4F15',
'OR51D1',
'CAMK2D',
'OR1C1',
'OR5K4',
'CAMK2A',
'OR5K3',
'CAMK2B',
'OR5K2',
'OR5K1',
'OR6M1',
'OR2T10',
'OR2T11',
'OR2T12',
'OR5H14',
'CAMK2G'],
'Phototransduction Homo sapiens hsa04744': ['RCVRN',
'PDE6G',
'GNB1',
'SAG',
'CALM2',
'CALM3',
'CNGB1',
'CALM1',
'GUCY2D',
'GUCY2F',
'CALML6',
'SLC24A1',
'GUCA1C',
'CALML3',
'GUCA1B',
'CALML5',
'GUCA1A',
'GRK1',
'GNGT1',
'GRK7',
'RHO',
'GNAT1',
'GNAT2',
'PDE6B',
'RGS9',
'PDE6A',
'CNGA1'],
'Circadian rhythm Homo sapiens hsa04710': ['FBXW11',
'NR1D1',
'CSNK1E',
'PRKAB1',
'PRKAB2',
'RBX1',
'PER3',
'PER2',
'CREB1',
'PER1',
'BHLHE40',
'BHLHE41',
'CRY2',
'CRY1',
'FBXL3',
'CLOCK',
'PRKAA2',
'PRKAG2',
'PRKAG3',
'CUL1',
'RORB',
'RORC',
'PRKAG1',
'NPAS2',
'RORA',
'PRKAA1',
'ARNTL',
'CSNK1D',
'BTRC',
'SKP1'],
'Glycerolipid metabolism Homo sapiens hsa00561': ['GK',
'AGK',
'GLYCTK',
'AKR1A1',
'DAK',
'LPIN1',
'GLA',
'AKR1B10',
'LPIN2',
'MGLL',
'LPIN3',
'PNLIPRP2',
'AGPAT6',
'DGKH',
'PNLIPRP3',
'DGKG',
'PNLIPRP1',
'AGPAT9',
'DGKE',
'DGKD',
'MOGAT3',
'MOGAT2',
'DGKB',
'MOGAT1',
'DGKA',
'AGPAT1',
'AGPAT2',
'LCLAT1',
'AGPAT3',
'AGPAT4',
'AGPAT5',
'DGAT2',
'DGAT1',
'CEL',
'MBOAT2',
'DGKZ',
'MBOAT1',
'ALDH3A2',
'ALDH7A1',
'PPAP2A',
'GPAM',
'PPAP2C',
'DGKQ',
'PPAP2B',
'ALDH9A1',
'DGKK',
'PNPLA2',
'PNPLA3',
'PNLIP',
'DGKI',
'AKR1B1',
'LPL',
'LIPC',
'GK2',
'LIPG',
'LIPF',
'ALDH1B1',
'ALDH2',
'GPAT2'],
'Glycerophospholipid metabolism Homo sapiens hsa00564': ['LYPLA2',
'PLA2G2E',
'LYPLA1',
'PLA2G2F',
'CHKB',
'PLA2G2C',
'CHKA',
'PLA2G2D',
'PLA2G2A',
'CRLS1',
'PISD',
'GPCPD1',
'ETNPPL',
'PHOSPHO1',
'LPIN1',
'ADPRM',
'GPD1',
'CHPT1',
'GPD2',
'GPD1L',
'LPIN2',
'LPIN3',
'ACHE',
'AGPAT6',
'DGKH',
'DGKG',
'AGPAT9',
'DGKE',
'DGKD',
'DGKB',
'DGKA',
'LCAT',
'AGPAT1',
'AGPAT2',
'LCLAT1',
'PLD2',
'AGPAT3',
'TAZ',
'PLD1',
'AGPAT4',
'PLD4',
'AGPAT5',
'PLD3',
'PGS1',
'PCYT1A',
'PLA2G12A',
'PLA2G12B',
'PCYT1B',
'PCYT2',
'PLA2G4E',
'MBOAT7',
'PLA2G4F',
'PLA2G4C',
'EPT1',
'PLA2G4D',
'MBOAT2',
'PLA2G4A',
'PLA2G4B',
'DGKZ',
'MBOAT1',
'PLA2G16',
'PLA2G15',
'PPAP2A',
'GPAM',
'PPAP2C',
'LPCAT4',
'ETNK2',
'GNPAT',
'PLA2G10',
'DGKQ',
'PPAP2B',
'ETNK1',
'LPCAT3',
'JMJD7-PLA2G4B',
'PNPLA6',
'PNPLA7',
'DGKK',
'PEMT',
'DGKI',
'CDS2',
'CDS1',
'LPGAT1',
'PLA2G1B',
'CHAT',
'LPCAT2',
'PLA2G3',
'LPCAT1',
'PLA2G5',
'PLA2G6',
'PLB1',
'PTDSS2',
'PTDSS1',
'GPAT2',
'CEPT1',
'CDIPT'],
'Ether lipid metabolism Homo sapiens hsa00565': ['PLA2G12A',
'TMEM86B',
'PLA2G12B',
'PLA2G2E',
'PLA2G2F',
'PLA2G4E',
'PLA2G2C',
'PLA2G4F',
'PLA2G2D',
'PLA2G4C',
'PLA2G2A',
'EPT1',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PAFAH2',
'PLA2G16',
'PPAP2A',
'CHPT1',
'PPAP2C',
'LPCAT4',
'AGPS',
'PLA2G10',
'PPAP2B',
'JMJD7-PLA2G4B',
'PAFAH1B1',
'PAFAH1B3',
'PAFAH1B2',
'GAL3ST1',
'PLA2G1B',
'LPCAT2',
'PLA2G3',
'LPCAT1',
'PLA2G5',
'PLA2G6',
'PLA2G7',
'PLD2',
'PLD1',
'PLD4',
'PLD3',
'PLB1',
'UGT8',
'ENPP2',
'CEPT1',
'ENPP6'],
'alpha-Linolenic acid metabolism Homo sapiens hsa00592': ['PLA2G12A',
'PLA2G12B',
'PLA2G2E',
'PLA2G2F',
'PLA2G4E',
'PLA2G2C',
'PLA2G4F',
'PLA2G2D',
'PLA2G4C',
'PLA2G2A',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PLA2G16',
'ACOX3',
'PLA2G10',
'ACOX1',
'JMJD7-PLA2G4B',
'PLA2G1B',
'PLA2G3',
'PLA2G5',
'PLA2G6',
'PLB1',
'ACAA1',
'FADS2'],
'Linoleic acid metabolism Homo sapiens hsa00591': ['PLA2G12A',
'PLA2G12B',
'PLA2G2E',
'PLA2G2F',
'PLA2G4E',
'PLA2G2C',
'PLA2G4F',
'PLA2G2D',
'PLA2G4C',
'PLA2G2A',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'PLA2G16',
'CYP2C9',
'CYP2C8',
'PLA2G10',
'JMJD7-PLA2G4B',
'CYP1A2',
'CYP2E1',
'PLA2G1B',
'ALOX15',
'PLA2G3',
'PLA2G5',
'PLA2G6',
'CYP3A4',
'CYP2C19',
'PLB1',
'CYP2J2'],
'Arachidonic acid metabolism Homo sapiens hsa00590': ['GPX1',
'GPX3',
'PLA2G2E',
'GPX2',
'PLA2G2F',
'GPX5',
'PTGES2',
'PLA2G2C',
'PTGES3',
'PLA2G2D',
'GPX7',
'CYP4A11',
'PLA2G2A',
'GPX6',
'GPX8',
'CYP2C9',
'CYP2U1',
'CYP2C8',
'ALOX15',
'ALOX12',
'ALOX12B',
'HPGDS',
'ALOX5',
'PTGDS',
'CBR3',
'GGT5',
'PLA2G12A',
'CBR1',
'PTGIS',
'PLA2G12B',
'PLA2G4E',
'CYP4F2',
'PLA2G4F',
'CYP4F3',
'PLA2G4C',
'EPHX2',
'PLA2G4D',
'PLA2G4A',
'PLA2G4B',
'AKR1C3',
'CYP4F8',
'FAM213B',
'ALOX15B',
'PLA2G16',
'TBXAS1',
'PLA2G10',
'JMJD7-PLA2G4B',
'CYP2E1',
'PTGES',
'PLA2G1B',
'PLA2G3',
'PLA2G5',
'PLA2G6',
'CYP2C19',
'PTGS1',
'PTGS2',
'LTC4S',
'PLB1',
'CYP2B6',
'LTA4H',
'GGT1',
'CYP2J2'],
'Fat digestion and absorption Homo sapiens hsa04975': ['ABCG8',
'PLA2G12A',
'PLA2G12B',
'PLA2G2E',
'PLA2G2F',
'ABCA1',
'GOT2',
'DGAT2',
'PLA2G2C',
'DGAT1',
'PLA2G2D',
'PLA2G2A',
'CEL',
'APOA4',
'FABP2',
'PPAP2A',
'CLPS',
'PPAP2C',
'PLA2G10',
'APOA1',
'PPAP2B',
'SLC27A4',
'ABCG5',
'PNLIP',
'FABP1',
'PNLIPRP2',
'PNLIPRP1',
'PLA2G1B',
'MOGAT3',
'MOGAT2',
'MTTP',
'PLA2G3',
'PLA2G5',
'AGPAT1',
'AGPAT2',
'ACAT2',
'LIPF',
'NPC1L1',
'CD36',
'SCARB1',
'APOB'],
'Vitamin digestion and absorption Homo sapiens hsa04977': ['CUBN',
'GIF',
'SLC46A1',
'SLC52A3',
'SLC23A1',
'APOA4',
'PLB1',
'SLC5A6',
'BTD',
'LMBRD1',
'FOLH1',
'AWAT2',
'TCN2',
'APOA1',
'RBP2',
'LRAT',
'MMACHC',
'ABCC1',
'SLC19A1',
'SCARB1',
'SLC19A2',
'PNLIP',
'APOB',
'SLC19A3'],
'Notch signaling pathway Homo sapiens hsa04330': ['CREBBP',
'PSENEN',
'JAG1',
'PTCRA',
'JAG2',
'DTX3L',
'KAT2B',
'SNW1',
'KAT2A',
'ADAM17',
'NCOR2',
'MFNG',
'NUMB',
'NOTCH3',
'NOTCH4',
'NOTCH1',
'NOTCH2',
'RBPJL',
'HDAC1',
'MAML3',
'CTBP2',
'HDAC2',
'MAML2',
'CTBP1',
'MAML1',
'DTX1',
'DTX2',
'PSEN1',
'DTX3',
'RFNG',
'PSEN2',
'DTX4',
'DLL1',
'DLL3',
'DLL4',
'RBPJ',
'APH1B',
'APH1A',
'LFNG',
'DVL1',
'EP300',
'DVL2',
'DVL3',
'CIR1',
'HES1',
'NCSTN',
'NUMBL',
'HES5'],
'Maturity onset diabetes of the young Homo sapiens hsa04950': ['PKLR',
'PAX4',
'PDX1',
'BHLHA15',
'HNF1B',
'PAX6',
'MAFA',
'GCK',
'NR5A2',
'HNF1A',
'IAPP',
'RFX6',
'NEUROG3',
'FOXA3',
'FOXA2',
'ONECUT1',
'SLC2A2',
'HNF4G',
'INS',
'HHEX',
'HNF4A',
'NKX2-2',
'HES1',
'NKX6-1',
'MNX1',
'NEUROD1'],
'Basal transcription factors Homo sapiens hsa03022': ['GTF2H2C_2',
'TBP',
'GTF2A1L',
'TAF15',
'TAF13',
'TAF11',
'TAF12',
'GTF2H1',
'TAF10',
'GTF2H2',
'GTF2H3',
'GTF2F1',
'GTF2H4',
'GTF2F2',
'GTF2H5',
'TAF1',
'TAF6L',
'CDK7',
'ERCC2',
'ERCC3',
'TBPL1',
'TAF9',
'TAF4B',
'TBPL2',
'TAF8',
'TAF7',
'GTF2IRD1',
'TAF6',
'GTF2H2C',
'TAF5',
'MNAT1',
'TAF4',
'TAF3',
'TAF2',
'GTF2A1',
'GTF2I',
'GTF2A2',
'CCNH',
'GTF2B',
'GTF2E1',
'GTF2E2',
'TAF1L',
'TAF5L',
'TAF7L',
'TAF9B'],
'Nucleotide excision repair Homo sapiens hsa03420': ['GTF2H2C_2',
'RFC4',
'RFC5',
'RFC2',
'LIG1',
'RFC3',
'RFC1',
'RPA2',
'GTF2H1',
'RPA3',
'GTF2H2',
'RAD23B',
'GTF2H3',
'RAD23A',
'RPA1',
'BIVM-ERCC5',
'GTF2H4',
'GTF2H5',
'RBX1',
'CUL4B',
'DDB2',
'CUL4A',
'DDB1',
'ERCC1',
'CDK7',
'ERCC4',
'ERCC5',
'POLE2',
'ERCC2',
'RPA4',
'POLE3',
'ERCC3',
'POLE4',
'ERCC8',
'ERCC6',
'GTF2H2C',
'MNAT1',
'PCNA',
'CETN2',
'CCNH',
'XPA',
'XPC',
'POLD4',
'POLE',
'POLD1',
'POLD2',
'POLD3'],
'Mismatch repair Homo sapiens hsa03430': ['PCNA',
'RFC4',
'MLH1',
'RFC5',
'RFC2',
'LIG1',
'RFC3',
'RFC1',
'RPA2',
'RPA3',
'MSH2',
'RPA1',
'MLH3',
'POLD4',
'MSH3',
'EXO1',
'POLD1',
'RPA4',
'POLD2',
'MSH6',
'POLD3',
'SSBP1',
'PMS2'],
'DNA replication Homo sapiens hsa03030': ['RFC4',
'RFC5',
'RFC2',
'LIG1',
'RFC3',
'RFC1',
'RPA2',
'RPA3',
'RPA1',
'RNASEH1',
'POLA1',
'POLA2',
'POLE2',
'RPA4',
'POLE3',
'POLE4',
'MCM4',
'MCM5',
'MCM6',
'DNA2',
'SSBP1',
'MCM7',
'RNASEH2A',
'MCM2',
'MCM3',
'PCNA',
'FEN1',
'RNASEH2C',
'RNASEH2B',
'PRIM2',
'PRIM1',
'POLD4',
'POLE',
'POLD1',
'POLD2',
'POLD3'],
'Base excision repair Homo sapiens hsa03410': ['MBD4',
'PARP4',
'PARP2',
'PARP3',
'LIG1',
'PARP1',
'XRCC1',
'LIG3',
'SMUG1',
'NEIL3',
'POLE2',
'APEX2',
'POLE3',
'APEX1',
'POLE4',
'NEIL2',
'NEIL1',
'PCNA',
'FEN1',
'MPG',
'OGG1',
'HMGB1',
'UNG',
'POLD4',
'POLB',
'POLE',
'NTHL1',
'POLD1',
'POLD2',
'TDG',
'POLD3',
'POLL',
'MUTYH'],
'Homologous recombination Homo sapiens hsa03440': ['TOP3A',
'XRCC3',
'SHFM1',
'TOP3B',
'RPA2',
'MRE11A',
'RPA3',
'XRCC2',
'RPA1',
'RAD50',
'RAD51C',
'RAD51B',
'RAD51',
'RAD51D',
'RAD52',
'RPA4',
'SSBP1',
'BLM',
'SYCP3',
'MUS81',
'BRCA2',
'RAD54B',
'POLD4',
'EME1',
'POLD1',
'POLD2',
'RAD54L',
'POLD3',
'NBN'],
'Fanconi anemia pathway Homo sapiens hsa03460': ['RMI1',
'RMI2',
'REV1',
'PALB2',
'C19ORF40',
'RAD51C',
'UBE2T',
'FANCD2',
'SLX1B',
'SLX1A',
'FAN1',
'ATR',
'C17ORF70',
'BRCA1',
'BRCA2',
'SLX4',
'USP1',
'HES1',
'PMS2',
'ATRIP',
'FANCI',
'FANCL',
'MLH1',
'FANCM',
'POLN',
'TOP3A',
'TOP3B',
'RPA2',
'FANCB',
'RPA3',
'FANCA',
'RPA1',
'FANCC',
'FANCF',
'FANCE',
'FANCG',
'ERCC1',
'APITD1',
'RAD51',
'ERCC4',
'RPA4',
'TELO2',
'WDR48',
'BLM',
'MUS81',
'BRIP1',
'EME1',
'EME2',
'POLK',
'STRA13',
'POLI',
'POLH',
'REV3L'],
'RNA polymerase Homo sapiens hsa03020': ['POLR2J2',
'POLR2J3',
'POLR3GL',
'POLR3A',
'POLR3B',
'POLR1A',
'POLR3C',
'POLR1B',
'POLR3D',
'POLR3E',
'POLR1C',
'POLR3F',
'POLR1D',
'POLR1E',
'POLR3G',
'POLR3H',
'POLR3K',
'LOC101060521',
'ZNRD1',
'POLR2A',
'POLR2B',
'POLR2C',
'TWISTNB',
'POLR2D',
'POLR2E',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'POLR2J',
'POLR2K',
'POLR2L'],
'Pyrimidine metabolism Homo sapiens hsa00240': ['ENTPD1',
'POLR2J2',
'ENTPD3',
'POLR2J3',
'DUT',
'ENTPD4',
'ENTPD5',
'ENTPD6',
'ENTPD8',
'UCKL1',
'UPB1',
'POLR3A',
'POLR3B',
'POLR3C',
'POLR3D',
'POLE2',
'POLR3E',
'POLE3',
'POLR3F',
'POLE4',
'POLR3G',
'POLR3H',
'UPRT',
'POLR3K',
'CDA',
'TYMP',
'TYMS',
'PNP',
'NT5E',
'TWISTNB',
'NT5C',
'NT5M',
'CTPS2',
'CTPS1',
'NT5C3B',
'DCTD',
'NT5C3A',
'UCK2',
'UCK1',
'ITPA',
'NT5C1B-RDH14',
'AK9',
'NME1-NME2',
'PNPT1',
'POLR3GL',
'TXNRD3',
'TXNRD2',
'TXNRD1',
'NME3',
'NME4',
'NME5',
'NME6',
'NME1',
'NME2',
'POLA1',
'POLA2',
'NT5C1A',
'NME7',
'RRM2B',
'NT5C1B',
'DPYD',
'DCTPP1',
'UMPS',
'LOC101060521',
'DTYMK',
'NT5C2',
'ZNRD1',
'TK1',
'TK2',
'RRM2',
'CAD',
'RRM1',
'DCK',
'DHODH',
'POLR1A',
'POLR1B',
'POLR1C',
'POLR1D',
'POLR1E',
'CMPK2',
'CMPK1',
'CANT1',
'DPYS',
'PRIM2',
'PRIM1',
'NUDT2',
'POLD4',
'POLE',
'POLR2A',
'POLR2B',
'POLR2C',
'POLD1',
'POLR2D',
'POLD2',
'POLR2E',
'POLD3',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'UPP2',
'POLR2J',
'UPP1',
'POLR2K',
'POLR2L'],
'Purine metabolism Homo sapiens hsa00230': ['GUCY1A3',
'ENTPD1',
'GUCY1A2',
'ENTPD2',
'POLR2J2',
'ENTPD3',
'POLR2J3',
'ENTPD4',
'ENTPD5',
'PDE6H',
'ENTPD6',
'PDE6G',
'ENTPD8',
'POLR3A',
'POLR3B',
'ADPRM',
'POLR3C',
'POLR3D',
'POLE2',
'POLR3E',
'POLE3',
'POLR3F',
'POLE4',
'POLR3G',
'POLR3H',
'POLR3K',
'PDE7B',
'PDE7A',
'ADCY10',
'ALLC',
'HDDC3',
'GDA',
'ADCY1',
'PRUNE',
'ADCY5',
'ADCY4',
'ADCY3',
'NTPCR',
'ADCY2',
'ADCY9',
'PAPSS1',
'ADCY8',
'ADCY7',
'ADCY6',
'PAPSS2',
'PNP',
'NT5E',
'TWISTNB',
'NT5C',
'NT5M',
'PDE8B',
'PDE8A',
'NT5C3B',
'NT5C3A',
'ADSSL1',
'ITPA',
'HPRT1',
'NT5C1B-RDH14',
'PDE9A',
'GUCY1B3',
'PDE1C',
'AK1',
'PDE1B',
'AK2',
'PDE1A',
'AK3',
'AK4',
'AK5',
'AK6',
'AK7',
'AK8',
'AK9',
'DGUOK',
'NME1-NME2',
'PPAT',
'PDE2A',
'PAICS',
'PNPT1',
'POLR3GL',
'AMPD1',
'NME3',
'AMPD2',
'NME4',
'AMPD3',
'NME5',
'NME6',
'NME1',
'NME2',
'POLA1',
'POLA2',
'NT5C1A',
'NME7',
'RRM2B',
'NT5C1B',
'PDE3B',
'PDE3A',
'GART',
'ADA',
'LOC101060521',
'GUCY2D',
'GUCY2C',
'GUCY2F',
'NPR1',
'NPR2',
'GMPR',
'ADK',
'GMPS',
'FHIT',
'PDE11A',
'NT5C2',
'ATIC',
'ZNRD1',
'URAD',
'PDE4C',
'PDE4B',
'PDE4A',
'PRPS1L1',
'RRM2',
'PKLR',
'ADSL',
'RRM1',
'PDE4D',
'DCK',
'APRT',
'CECR1',
'PKM',
'PDE10A',
'NUDT9',
'IMPDH1',
'POLR1A',
'IMPDH2',
'POLR1B',
'POLR1C',
'POLR1D',
'POLR1E',
'PDE5A',
'LOC390877',
'PRPS2',
'PFAS',
'CANT1',
'GMPR2',
'PRPS1',
'PRIM2',
'PRIM1',
'NUDT2',
'NUDT5',
'POLD4',
'GUK1',
'POLE',
'POLR2A',
'POLR2B',
'POLR2C',
'POLD1',
'ENPP1',
'POLR2D',
'POLD2',
'POLR2E',
'POLD3',
'ENPP3',
'POLR2F',
'POLR2G',
'PDE6D',
'POLR2H',
'PDE6C',
'XDH',
'POLR2I',
'ENPP4',
'PDE6B',
'ADSS',
'POLR2J',
'NUDT16',
'PDE6A',
'POLR2K',
'PGM2',
'POLR2L',
'PGM1'],
'Nicotinate and nicotinamide metabolism Homo sapiens hsa00760': ['NMNAT3',
'NT5C3B',
'NT5C1A',
'BST1',
'NT5C3A',
'NMNAT2',
'NMNAT1',
'NT5C1B',
'NT5C1B-RDH14',
'NNMT',
'QPRT',
'NADSYN1',
'NT5C2',
'NUDT12',
'PNP',
'NT5E',
'NNT',
'NAMPT',
'ENPP1',
'NMRK2',
'NMRK1',
'NAPRT',
'NT5C',
'ENPP3',
'AOX1',
'NT5M',
'CD38',
'NADK',
'NADK2'],
'Non-homologous end-joining Homo sapiens hsa03450': ['DCLRE1C',
'FEN1',
'XRCC5',
'XRCC6',
'XRCC4',
'MRE11A',
'DNTT',
'LIG4',
'PRKDC',
'RAD50',
'POLM',
'POLL',
'NHEJ1'],
'Primary immunodeficiency Homo sapiens hsa05340': ['AICDA',
'RFXANK',
'TAP2',
'TAP1',
'PTPRC',
'LCK',
'ZAP70',
'CD4',
'IGLL1',
'CD8B',
'CD8A',
'RFX5',
'RFXAP',
'BTK',
'ORAI1',
'CD40LG',
'ADA',
'IL7R',
'DCLRE1C',
'CD40',
'TNFRSF13C',
'AIRE',
'TNFRSF13B',
'IL2RG',
'UNG',
'CD3E',
'CD3D',
'LOC102723407',
'CD79A',
'CD19',
'BLNK',
'JAK3',
'IKBKG',
'CIITA',
'RAG1',
'ICOS',
'RAG2'],
'ABC transporters Homo sapiens hsa02010': ['ABCG8',
'ABCC4',
'ABCA2',
'ABCA3',
'ABCC5',
'ABCC2',
'ABCA1',
'ABCC3',
'ABCC8',
'ABCA6',
'ABCA7',
'ABCC9',
'ABCA4',
'ABCC6',
'ABCA5',
'TAP2',
'ABCA8',
'TAP1',
'ABCA9',
'ABCA10',
'ABCB10',
'ABCB11',
'ABCA12',
'ABCC10',
'ABCG1',
'ABCG4',
'ABCC1',
'ABCG5',
'ABCG2',
'CFTR',
'ABCB4',
'ABCB1',
'ABCD3',
'ABCD4',
'ABCB7',
'ABCB8',
'ABCB5',
'ABCB6',
'ABCB9',
'ABCA13',
'ABCC11',
'ABCC12',
'ABCD1',
'ABCD2'],
'Proteasome Homo sapiens hsa03050': ['SHFM1',
'PSMB9',
'PSMA6',
'PSMA7',
'PSMA4',
'PSMC6',
'PSMA5',
'PSMA2',
'PSMC4',
'PSMA3',
'PSMC5',
'PSME4',
'PSMC2',
'IFNG',
'PSMA1',
'PSMC3',
'PSME2',
'PSME3',
'PSMC1',
'PSME1',
'PSMD11',
'PSMD13',
'PSMD12',
'POMP',
'PSMD14',
'PSMB11',
'PSMA8',
'PSMB10',
'PSMB7',
'PSMB8',
'PSMB5',
'PSMD7',
'PSMB6',
'PSMD8',
'PSMB3',
'PSMB4',
'PSMD6',
'PSMB1',
'PSMD3',
'PSMB2',
'PSMD4',
'PSMD1',
'PSMD2',
'PSMF1'],
'Vitamin B6 metabolism Homo sapiens hsa00750': ['PHOSPHO2',
'PDXK',
'PSAT1',
'AOX1',
'PNPO',
'PDXP'],
'Nitrogen metabolism Homo sapiens hsa00910': ['CA13',
'CA12',
'GLUD1',
'GLUD2',
'CA2',
'CA1',
'CA4',
'CPS1',
'CA3',
'CA5B',
'CA5A',
'CA6',
'CA8',
'CA7',
'GLUL',
'CA9',
'CA14'],
'Alanine, aspartate and glutamate metabolism Homo sapiens hsa00250': ['GOT2',
'GFPT1',
'CAD',
'GOT1',
'ADSL',
'GAD2',
'GPT2',
'GFPT2',
'GAD1',
'ASNS',
'GLUD1',
'ALDH5A1',
'ASS1',
'GLUD2',
'ALDH4A1',
'FOLH1',
'CPS1',
'ADSSL1',
'AGXT2',
'ASPA',
'NIT2',
'NAT8L',
'AGXT',
'GLS2',
'GPT',
'GLS',
'ABAT',
'DDO',
'IL4I1',
'PPAT',
'ASL',
'GLUL',
'RIMKLB',
'ADSS',
'RIMKLA'],
'Arginine biosynthesis Homo sapiens hsa00220': ['GLS2',
'NOS3',
'GOT2',
'ARG1',
'GOT1',
'ARG2',
'ACY1',
'GPT2',
'GPT',
'GLS',
'GLUD1',
'ASS1',
'GLUD2',
'CPS1',
'ASL',
'NOS1',
'NAGS',
'GLUL',
'NOS2',
'OTC'],
'Proximal tubule bicarbonate reclamation Homo sapiens hsa04964': ['GLS2',
'ATP1A4',
'ATP1A3',
'ATP1B4',
'ATP1A2',
'ATP1B3',
'ATP1A1',
'ATP1B2',
'GLS',
'SLC4A4',
'ATP1B1',
'AQP1',
'SLC9A3',
'GLUD1',
'GLUD2',
'CA2',
'CA4',
'FXYD2',
'MDH1',
'SLC25A10',
'PCK2',
'PCK1',
'SLC38A3'],
'Mineral absorption Homo sapiens hsa04978': ['VDR',
'CYBRD1',
'ATP1B4',
'SLC31A1',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'SLC9A3',
'TF',
'MT1A',
'MT1B',
'FXYD2',
'TRPV6',
'SLC26A9',
'MT1G',
'MT1H',
'STEAP2',
'MT1E',
'STEAP1',
'SLC26A6',
'MT1F',
'SLC46A1',
'ATP1A4',
'ATP1A3',
'SLC5A1',
'ATP1A2',
'SLC40A1',
'ATP1A1',
'SLC39A4',
'S100G',
'SLC6A19',
'SLC11A1',
'SLC34A2',
'SLC11A2',
'SLC30A1',
'ATP2B1',
'ATOX1',
'FTL',
'SLC26A3',
'MT1M',
'MT1X',
'SLC8A1',
'CLCN2',
'MT2A',
'HEPH',
'FTH1',
'HMOX1',
'HMOX2',
'TRPM6',
'ATP7A',
'TRPM7'],
'Protein digestion and absorption Homo sapiens hsa04974': ['KCNJ13',
'COL24A1',
'ATP1B4',
'ATP1B3',
'ATP1B2',
'ATP1B1',
'COL1A2',
'SLC9A3',
'COL1A1',
'SLC7A7',
'SLC7A8',
'COL3A1',
'XPNPEP2',
'SLC7A9',
'COL5A2',
'CTRL',
'COL5A1',
'FXYD2',
'COL7A1',
'COL5A3',
'COL9A2',
'COL9A1',
'COL22A1',
'COL9A3',
'KCNK5',
'COL18A1',
'PRSS2',
'PRSS1',
'COL14A1',
'SLC1A1',
'COL12A1',
'ELN',
'SLC3A1',
'ATP1A4',
'SLC3A2',
'ATP1A3',
'SLC1A5',
'ATP1A2',
'PRCP',
'ATP1A1',
'DPP4',
'COL10A1',
'PRSS3',
'CPA3',
'CELA2A',
'SLC36A1',
'SLC15A1',
'SLC38A2',
'CELA2B',
'CPA2',
'COL27A1',
'CPA1',
'SLC6A19',
'MME',
'SLC16A10',
'PGA4',
'PGA3',
'PGA5',
'COL2A1',
'ACE2',
'COL4A1',
'COL6A1',
'COL4A3',
'KCNQ1',
'COL4A2',
'MEP1B',
'COL6A3',
'COL4A5',
'COL6A2',
'COL4A4',
'COL6A5',
'CTRB1',
'COL21A1',
'COL4A6',
'MEP1A',
'COL6A6',
'CELA3A',
'CELA3B',
'CPB2',
'COL17A1',
'KCNE3',
'CPB1',
'COL15A1',
'COL11A2',
'COL13A1',
'SLC8A1',
'SLC8A2',
'SLC8A3',
'COL11A1',
'KCNN4'],
'Renin-angiotensin system Homo sapiens hsa04614': ['ENPEP',
'CPA3',
'CTSA',
'ACE',
'ATP6AP2',
'KLK2',
'KLK1',
'MME',
'CMA1',
'PREP',
'LNPEP',
'PRCP',
'AGT',
'NLN',
'ACE2',
'MAS1',
'ANPEP',
'MRGPRD',
'AGTR2',
'AGTR1',
'THOP1',
'REN',
'CTSG'],
'Glutathione metabolism Homo sapiens hsa00480': ['GPX1',
'GSTM5',
'GSTM4',
'GPX3',
'GSTM3',
'GPX2',
'G6PD',
'GSTM2',
'GPX5',
'GSR',
'GSTM1',
'GPX4',
'GPX7',
'GPX6',
'GSS',
'GPX8',
'LAP3',
'GSTA5',
'RRM2B',
'GSTA4',
'GSTA3',
'GSTA2',
'GSTA1',
'ODC1',
'HPGDS',
'GSTT2B',
'GGT6',
'GGT5',
'IDH1',
'RRM2',
'GSTK1',
'GGT7',
'RRM1',
'GSTO2',
'IDH2',
'GSTO1',
'PGD',
'GGCT',
'GCLC',
'SMS',
'GCLM',
'GSTP1',
'MGST2',
'TXNDC12',
'MGST3',
'GSTT2',
'GSTT1',
'MGST1',
'SRM',
'OPLAH',
'ANPEP',
'GGT1'],
'Cyanoamino acid metabolism Homo sapiens hsa00460': ['GGT6',
'GGT5',
'GGT7',
'SHMT2',
'SHMT1',
'GGT1',
'GBA3'],
'Taurine and hypotaurine metabolism Homo sapiens hsa00430': ['GGT6',
'GGT5',
'GGT7',
'GAD2',
'GAD1',
'GADL1',
'ADO',
'CSAD',
'CDO1',
'GGT1',
'BAAT'],
'Caffeine metabolism Homo sapiens hsa00232': ['CYP2A6',
'NAT2',
'CYP1A2',
'XDH',
'NAT1'],
'Chemical carcinogenesis Homo sapiens hsa05204': ['GSTM5',
'GSTM4',
'GSTM3',
'GSTM2',
'GSTM1',
'UGT2A1',
'CYP3A43',
'CYP2C9',
'CYP2C8',
'GSTA5',
'GSTA4',
'GSTA3',
'GSTA2',
'GSTA1',
'CYP1A2',
'CYP1A1',
'UGT1A10',
'ADH1C',
'ADH1B',
'CHRNA7',
'ADH1A',
'CCBL2',
'CCBL1',
'CYP3A4',
'CYP3A5',
'CYP3A7',
'SULT2A1',
'HPGDS',
'GSTT2B',
'CYP1B1',
'UGT2A3',
'UGT2A2',
'HSD11B1',
'UGT2B11',
'UGT2B10',
'CBR1',
'GSTK1',
'EPHX1',
'UGT2B15',
'GSTO2',
'UGT1A1',
'GSTO1',
'UGT2B17',
'AKR1C2',
'ARNT',
'NAT1',
'CYP3A7-CYP3AP1',
'CYP2A6',
'NAT2',
'ALDH1A3',
'ALDH3A1',
'UGT2B4',
'CYP2E1',
'UGT2B7',
'UGT2B28',
'GSTP1',
'MGST2',
'MGST3',
'GSTT2',
'GSTT1',
'MGST1',
'CYP2C19',
'CYP2C18',
'ADH6',
'PTGS2',
'ADH7',
'ADH4',
'SULT1A2',
'ADH5',
'SULT1A1',
'CYP2A13',
'ALDH3B2',
'ALDH3B1',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT1A3',
'UGT1A9',
'UGT1A8',
'SULT1A4',
'UGT1A7',
'SULT1A3'],
'Metabolism of xenobiotics by cytochrome P450 Homo sapiens hsa00980': ['GSTM5',
'GSTM4',
'GSTM3',
'GSTM2',
'GSTM1',
'UGT2A1',
'DHDH',
'AKR7A2',
'CYP2C9',
'GSTA5',
'GSTA4',
'GSTA3',
'GSTA2',
'GSTA1',
'CYP1A2',
'CYP1A1',
'UGT1A10',
'ADH1C',
'ADH1B',
'ADH1A',
'CYP3A4',
'CYP3A5',
'SULT2A1',
'HPGDS',
'CYP2D6',
'GSTT2B',
'CYP1B1',
'UGT2A3',
'UGT2A2',
'HSD11B1',
'CBR3',
'UGT2B11',
'UGT2B10',
'CBR1',
'GSTK1',
'EPHX1',
'UGT2B15',
'GSTO2',
'UGT1A1',
'GSTO1',
'UGT2B17',
'AKR1C1',
'CYP2A6',
'CYP2S1',
'ALDH1A3',
'ALDH3A1',
'UGT2B4',
'CYP2E1',
'UGT2B7',
'UGT2B28',
'GSTP1',
'MGST2',
'MGST3',
'GSTT2',
'GSTT1',
'MGST1',
'ADH6',
'ADH7',
'ADH4',
'ADH5',
'AKR7A3',
'CYP2B6',
'CYP2A13',
'ALDH3B2',
'ALDH3B1',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT1A3',
'UGT1A9',
'CYP2F1',
'UGT1A8',
'UGT1A7'],
'Drug metabolism - cytochrome P450 Homo sapiens hsa00982': ['GSTM5',
'GSTM4',
'GSTM3',
'GSTM2',
'GSTM1',
'UGT2A1',
'CYP2C9',
'CYP2C8',
'GSTA5',
'GSTA4',
'GSTA3',
'GSTA2',
'GSTA1',
'CYP1A2',
'UGT1A10',
'MAOB',
'ADH1C',
'MAOA',
'ADH1B',
'ADH1A',
'CYP3A4',
'CYP3A5',
'HPGDS',
'CYP2D6',
'AOX1',
'GSTT2B',
'UGT2A3',
'UGT2A2',
'UGT2B11',
'UGT2B10',
'GSTK1',
'UGT2B15',
'GSTO2',
'UGT1A1',
'GSTO1',
'UGT2B17',
'FMO1',
'FMO2',
'FMO3',
'FMO4',
'FMO5',
'CYP2A6',
'ALDH1A3',
'ALDH3A1',
'UGT2B4',
'CYP2E1',
'UGT2B7',
'UGT2B28',
'GSTP1',
'MGST2',
'MGST3',
'GSTT2',
'GSTT1',
'MGST1',
'CYP2C19',
'ADH6',
'ADH7',
'ADH4',
'ADH5',
'CYP2B6',
'ALDH3B2',
'ALDH3B1',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT1A3',
'UGT1A9',
'UGT1A8',
'UGT1A7'],
'Retinol metabolism Homo sapiens hsa00830': ['UGT2A1',
'CYP4A11',
'CYP2C9',
'CYP26A1',
'CYP2C8',
'RDH5',
'CYP1A2',
'CYP1A1',
'UGT1A10',
'RETSAT',
'ADH1C',
'ADH1B',
'ADH1A',
'HSD17B6',
'CYP3A4',
'CYP3A5',
'CYP3A7',
'CYP26B1',
'AWAT2',
'RDH12',
'RDH11',
'RDH10',
'AOX1',
'RDH16',
'UGT2A3',
'UGT2A2',
'SDR16C5',
'UGT2B11',
'UGT2B10',
'UGT2B15',
'DGAT1',
'UGT1A1',
'UGT2B17',
'DHRS3',
'RPE65',
'DHRS4',
'CYP3A7-CYP3AP1',
'DHRS9',
'CYP2A6',
'ALDH1A1',
'CYP26C1',
'CYP2S1',
'ALDH1A2',
'PNPLA4',
'UGT2B4',
'UGT2B7',
'UGT2B28',
'RDH8',
'CYP2C18',
'ADH6',
'ADH7',
'ADH4',
'ADH5',
'CYP2B6',
'UGT1A6',
'UGT1A5',
'DHRS4L2',
'UGT1A4',
'UGT1A3',
'LRAT',
'BCO1',
'DHRS4L1',
'UGT1A9',
'UGT1A8',
'UGT1A7'],
'Steroid hormone biosynthesis Homo sapiens hsa00140': ['SRD5A3',
'UGT2A1',
'SRD5A2',
'HSD3B1',
'HSD3B2',
'CYP7B1',
'CYP11B2',
'CYP11B1',
'CYP1A2',
'CYP1A1',
'UGT1A10',
'AKR1D1',
'HSD17B6',
'HSD17B7',
'CYP3A4',
'CYP7A1',
'HSD17B8',
'CYP3A5',
'COMT',
'CYP3A7',
'STS',
'HSD11B2',
'HSD17B1',
'HSD17B2',
'HSD17B3',
'CYP1B1',
'UGT2A3',
'UGT2A2',
'HSD11B1',
'UGT2B11',
'UGT2B10',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'AKR1C2',
'AKR1C1',
'AKR1C4',
'AKR1C3',
'CYP3A7-CYP3AP1',
'SULT2B1',
'CYP21A2',
'UGT2B4',
'CYP2E1',
'UGT2B7',
'UGT2B28',
'HSD17B12',
'CYP19A1',
'CYP17A1',
'SULT1E1',
'CYP11A1',
'UGT1A6',
'UGT1A5',
'SRD5A1',
'UGT1A4',
'UGT1A3',
'UGT1A9',
'UGT1A8',
'UGT1A7'],
'Drug metabolism - other enzymes Homo sapiens hsa00983': ['UGT2B11',
'UGT2B10',
'UGT2A1',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'NAT1',
'UCKL1',
'UPB1',
'UCK2',
'CYP2A6',
'IMPDH1',
'UCK1',
'NAT2',
'IMPDH2',
'DPYD',
'ITPA',
'HPRT1',
'UGT2B4',
'UMPS',
'CDA',
'UGT2B7',
'CES2',
'TYMP',
'CES1',
'UGT1A10',
'DPYS',
'TPMT',
'UGT2B28',
'GMPS',
'CYP3A4',
'TK1',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT2A3',
'XDH',
'TK2',
'UPP2',
'UGT1A3',
'UGT2A2',
'UPP1',
'GUSB',
'UGT1A9',
'UGT1A8',
'UGT1A7'],
'Porphyrin and chlorophyll metabolism Homo sapiens hsa00860': ['UGT2B11',
'UGT2B10',
'MMAB',
'UGT2A1',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'UROS',
'CP',
'HMBS',
'FXN',
'UGT2B4',
'BLVRB',
'BLVRA',
'UGT2B7',
'UGT1A10',
'FECH',
'ALAS2',
'ALAS1',
'UGT2B28',
'CPOX',
'HCCS',
'EPRS',
'PPOX',
'ALAD',
'HEPH',
'UROD',
'HMOX1',
'UGT1A6',
'HMOX2',
'UGT1A5',
'COX15',
'UGT1A4',
'UGT2A3',
'UGT1A3',
'UGT2A2',
'GUSB',
'UGT1A9',
'UGT1A8',
'COX10',
'UGT1A7',
'EARS2'],
'Ascorbate and aldarate metabolism Homo sapiens hsa00053': ['MIOX',
'UGT2B11',
'UGT2B10',
'UGT2A1',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'ALDH3A2',
'ALDH7A1',
'UGDH',
'RGN',
'UGT2B4',
'ALDH9A1',
'UGT2B7',
'UGT1A10',
'UGT2B28',
'ALDH1B1',
'ALDH2',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT2A3',
'UGT1A3',
'UGT2A2',
'UGT1A9',
'UGT1A8',
'UGT1A7'],
'Pentose and glucuronate interconversions Homo sapiens hsa00040': ['KL',
'UGT2B11',
'UGT2B10',
'UGT2A1',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'DCXR',
'DHDH',
'AKR1A1',
'SORD',
'ALDH3A2',
'UGDH',
'CRYL1',
'UGT2B4',
'AKR1B10',
'UGT2B7',
'UGT1A10',
'RPEL1',
'AKR1B1',
'UGT2B28',
'RPE',
'UGP2',
'ALDH1B1',
'ALDH2',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT2A3',
'UGT1A3',
'UGT2A2',
'GUSB',
'UGT1A9',
'UGT1A8',
'XYLB',
'UGT1A7'],
'Starch and sucrose metabolism Homo sapiens hsa00500': ['G6PC',
'KL',
'AMY1A',
'UGT2A1',
'AGL',
'AMY1B',
'AMY1C',
'G6PC2',
'GANC',
'GCK',
'G6PC3',
'UGDH',
'GPI',
'UGT1A10',
'HK1',
'HK3',
'HK2',
'UGP2',
'UGT2A3',
'UGT2A2',
'UGT2B11',
'MGAM',
'UGT2B10',
'UGT2B15',
'UGT1A1',
'UGT2B17',
'GAA',
'PGM2L1',
'HKDC1',
'UGT2B4',
'UGT2B7',
'AMY2A',
'AMY2B',
'PYGB',
'UGT2B28',
'GBE1',
'TREH',
'UXS1',
'PYGL',
'PYGM',
'GBA3',
'GYS1',
'GYS2',
'SI',
'ENPP1',
'ENPP3',
'UGT1A6',
'UGT1A5',
'UGT1A4',
'UGT1A3',
'GUSB',
'UGT1A9',
'PGM2',
'UGT1A8',
'PGM1',
'UGT1A7'],
'Galactose metabolism Homo sapiens hsa00052': ['G6PC',
'MGAM',
'GAA',
'G6PC2',
'GANC',
'GCK',
'GALK1',
'G6PC3',
'GLB1',
'PFKM',
'PFKL',
'GALE',
'HKDC1',
'LALBA',
'GLA',
'GALM',
'AKR1B10',
'LCT',
'PFKP',
'GALT',
'B4GALT1',
'B4GALT2',
'AKR1B1',
'HK1',
'HK3',
'HK2',
'UGP2',
'SI',
'PGM2',
'PGM1'],
'Butirosin and neomycin biosynthesis Homo sapiens hsa00524': ['HKDC1',
'HK1',
'HK3',
'GCK',
'HK2'],
'Amino sugar and nucleotide sugar metabolism Homo sapiens hsa00520': ['CHIA',
'GFPT1',
'PMM2',
'PMM1',
'GFPT2',
'RENBP',
'GCK',
'GALK1',
'CHIT1',
'UGDH',
'GNPDA1',
'NAGK',
'GNPDA2',
'GALE',
'HKDC1',
'CYB5RL',
'GNE',
'GPI',
'TSTA3',
'GALT',
'HEXA',
'CMAS',
'MPI',
'HEXB',
'UXS1',
'NPL',
'UAP1',
'HK1',
'HK3',
'HK2',
'CYB5R3',
'NANP',
'CYB5R2',
'CYB5R4',
'NANS',
'UGP2',
'UAP1L1',
'AMDHD2',
'GMDS',
'GMPPA',
'FPGT',
'GMPPB',
'GNPNAT1',
'PGM3',
'FUK',
'CYB5R1',
'PGM2',
'PGM1'],
'Fructose and mannose metabolism Homo sapiens hsa00051': ['TPI1',
'PMM2',
'PMM1',
'SORD',
'C12ORF5',
'PFKM',
'PFKL',
'HKDC1',
'ALDOC',
'AKR1B10',
'ALDOB',
'FBP1',
'ALDOA',
'FBP2',
'PFKFB1',
'PFKP',
'PFKFB3',
'TSTA3',
'PFKFB2',
'PFKFB4',
'MPI',
'AKR1B1',
'KHK',
'HK1',
'HK3',
'HK2',
'GMDS',
'GMPPA',
'FPGT',
'GMPPB',
'ENOSF1',
'FUK'],
'Pentose phosphate pathway Homo sapiens hsa00030': ['TKTL2',
'TKTL1',
'G6PD',
'TALDO1',
'PGD',
'DERA',
'RBKS',
'PFKM',
'PFKL',
'RPIA',
'IDNK',
'RGN',
'ALDOC',
'ALDOB',
'FBP1',
'ALDOA',
'FBP2',
'TKT',
'GPI',
'PFKP',
'H6PD',
'PRPS2',
'RPEL1',
'PRPS1',
'RPE',
'PGLS',
'PRPS1L1',
'PGM2',
'PGM1'],
'Carbon metabolism Homo sapiens hsa01200': ['G6PD',
'GPT2',
'SDHD',
'SDHB',
'SDHC',
'GCK',
'SDHA',
'PC',
'PSAT1',
'IDNK',
'SUCLG2',
'SUCLG1',
'RPEL1',
'DLST',
'PDHB',
'ACSS2',
'ACSS1',
'SDS',
'IDH1',
'GOT2',
'GOT1',
'IDH2',
'MTHFR',
'TALDO1',
'PGD',
'PGP',
'OGDH',
'GLDC',
'ENO1',
'ENO2',
'ENO3',
'ADH5',
'ESD',
'PSPH',
'PDHA2',
'TPI1',
'PDHA1',
'DAK',
'CS',
'GLUD1',
'GLUD2',
'ALDH6A1',
'PCCB',
'CPS1',
'PCCA',
'ACO2',
'ALDOC',
'ALDOB',
'FBP1',
'ACO1',
'ALDOA',
'FBP2',
'GPI',
'H6PD',
'SHMT2',
'SHMT1',
'ACAT1',
'EHHADH',
'GPT',
'ECHS1',
'HK1',
'HK3',
'ACAT2',
'SDSL',
'HK2',
'ME2',
'PGK2',
'ME1',
'PGK1',
'HAO2',
'ME3',
'PHGDH',
'HAO1',
'HIBCH',
'PRPS1L1',
'TKTL2',
'TKTL1',
'IDH3G',
'MDH2',
'PGAM1',
'PKLR',
'PGAM2',
'AMT',
'MUT',
'PKM',
'PFKM',
'PFKL',
'RPIA',
'SUCLA2',
'CAT',
'HADHA',
'HKDC1',
'PGAM4',
'RGN',
'DLD',
'TKT',
'GAPDH',
'PFKP',
'AGXT',
'FH',
'PRPS2',
'ADPGK',
'PRPS1',
'RPE',
'MCEE',
'ACADM',
'OGDHL',
'PGLS',
'DLAT',
'MDH1',
'ACADS',
'IDH3A',
'IDH3B'],
'Biosynthesis of amino acids Homo sapiens hsa01230': ['TPI1',
'GPT2',
'PYCR1',
'PYCR2',
'LOC102724560',
'CS',
'ASS1',
'PC',
'PSAT1',
'CPS1',
'CTH',
'PAH',
'ALDH18A1',
'ACO2',
'ALDOC',
'OTC',
'ALDOB',
'ACO1',
'ALDOA',
'PYCRL',
'RPEL1',
'SHMT2',
'TAT',
'ACY1',
'SHMT1',
'MTR',
'GPT',
'SDSL',
'PGK2',
'PGK1',
'PHGDH',
'PRPS1L1',
'SDS',
'IDH1',
'TKTL2',
'TKTL1',
'AADAT',
'GOT2',
'ARG1',
'IDH3G',
'GOT1',
'ARG2',
'PGAM1',
'PKLR',
'IDH2',
'PGAM2',
'TALDO1',
'PKM',
'ALDH7A1',
'PFKM',
'PFKL',
'RPIA',
'MAT1A',
'PGAM4',
'NAGS',
'BCAT2',
'BCAT1',
'TKT',
'GAPDH',
'PFKP',
'PRPS2',
'PRPS1',
'RPE',
'ENO1',
'ENO2',
'ENO3',
'CBS',
'MAT2B',
'MAT2A',
'ASL',
'GLUL',
'IDH3A',
'IDH3B',
'PSPH'],
'2-Oxocarboxylic acid metabolism Homo sapiens hsa01210': ['IDH1',
'AADAT',
'GOT2',
'IDH3G',
'GOT1',
'IDH2',
'ACY1',
'GPT2',
'GPT',
'CS',
'NAGS',
'ACO2',
'BCAT2',
'BCAT1',
'ACO1',
'IDH3A',
'IDH3B'],
'Citrate cycle (TCA cycle) Homo sapiens hsa00020': ['IDH1',
'PDHA2',
'IDH3G',
'MDH2',
'PDHA1',
'IDH2',
'SDHD',
'SDHB',
'SDHC',
'CS',
'SDHA',
'ACLY',
'PC',
'SUCLA2',
'SUCLG2',
'ACO2',
'DLD',
'SUCLG1',
'ACO1',
'OGDH',
'FH',
'DLST',
'PDHB',
'OGDHL',
'DLAT',
'MDH1',
'PCK2',
'PCK1',
'IDH3A',
'IDH3B'],
'Pyruvate metabolism Homo sapiens hsa00620': ['PDHA2',
'MDH2',
'PDHA1',
'HAGHL',
'ACYP1',
'PKLR',
'ACOT12',
'ACYP2',
'PKM',
'GRHPR',
'ALDH3A2',
'ALDH7A1',
'PC',
'HAGH',
'DLD',
'ALDH9A1',
'LDHAL6A',
'LDHAL6B',
'FH',
'GLO1',
'ACAT1',
'PDHB',
'ACACB',
'ACAT2',
'ACACA',
'LDHD',
'LDHC',
'LDHB',
'LDHA',
'ALDH1B1',
'ALDH2',
'ME2',
'ME1',
'DLAT',
'MDH1',
'ME3',
'PCK2',
'ACSS2',
'PCK1',
'ACSS1'],
'Glycolysis / Gluconeogenesis Homo sapiens hsa00010': ['G6PC',
'PDHA2',
'TPI1',
'PDHA1',
'AKR1A1',
'G6PC2',
'GCK',
'G6PC3',
'GAPDHS',
'ALDOC',
'ALDOB',
'FBP1',
'ALDOA',
'FBP2',
'GPI',
'ADH1C',
'ADH1B',
'ADH1A',
'PDHB',
'HK1',
'HK3',
'HK2',
'LDHC',
'LDHB',
'LDHA',
'PGK2',
'PGK1',
'PCK2',
'ACSS2',
'PCK1',
'ACSS1',
'PGAM1',
'PKLR',
'PGAM2',
'BPGM',
'PKM',
'MINPP1',
'ALDH3A2',
'ALDH7A1',
'PFKM',
'PFKL',
'ALDH1A3',
'ALDH3A1',
'HKDC1',
'PGAM4',
'DLD',
'GALM',
'ALDH9A1',
'LDHAL6A',
'GAPDH',
'LDHAL6B',
'PFKP',
'ADPGK',
'ENO1',
'ENO2',
'ENO3',
'ADH6',
'ADH7',
'ADH4',
'ADH5',
'ALDH1B1',
'ALDH2',
'ALDH3B2',
'ALDH3B1',
'DLAT',
'PGM2',
'PGM1'],
'Glycine, serine and threonine metabolism Homo sapiens hsa00260': ['SDS',
'GAMT',
'AOC2',
'AOC3',
'PGAM1',
'GLYCTK',
'PGAM2',
'AMT',
'BPGM',
'GNMT',
'LOC102724560',
'GCAT',
'GRHPR',
'DAO',
'ALDH7A1',
'BHMT',
'GATM',
'PSAT1',
'CTH',
'CHDH',
'SARDH',
'PGAM4',
'AGXT2',
'DLD',
'AGXT',
'GLDC',
'ALAS2',
'DMGDH',
'ALAS1',
'MAOB',
'MAOA',
'SHMT2',
'SHMT1',
'SDSL',
'GCSH',
'CBS',
'SRR',
'PIPOX',
'PHGDH',
'PSPH'],
'Glyoxylate and dicarboxylate metabolism Homo sapiens hsa00630': ['MDH2',
'GLYCTK',
'AMT',
'MUT',
'CS',
'GRHPR',
'HOGA1',
'PCCB',
'CAT',
'PCCA',
'PGP',
'ACO2',
'DLD',
'ACO1',
'AGXT',
'GLDC',
'SHMT2',
'SHMT1',
'ACAT1',
'ACAT2',
'MCEE',
'GCSH',
'AFMID',
'HYI',
'GLUL',
'HAO2',
'MDH1',
'HAO1'],
'Pantothenate and CoA biosynthesis Homo sapiens hsa00770': ['PANK3',
'PANK4',
'PANK1',
'PANK2',
'DPYS',
'GADL1',
'PPCS',
'PPCDC',
'UPB1',
'COASY',
'VNN1',
'VNN2',
'ENPP1',
'DPYD',
'ENPP3',
'BCAT2',
'BCAT1',
'AASDHPPT'],
'Cysteine and methionine metabolism Homo sapiens hsa00270': ['SDS',
'GOT2',
'MDH2',
'GOT1',
'DNMT3A',
'BHMT2',
'GSS',
'DNMT3B',
'MPST',
'LOC102724560',
'MTAP',
'GCLC',
'BHMT',
'ADI1',
'MAT1A',
'TST',
'CTH',
'SMS',
'AGXT2',
'BCAT2',
'CDO1',
'GCLM',
'DNMT1',
'BCAT1',
'LDHAL6A',
'LDHAL6B',
'AHCYL1',
'AHCY',
'AHCYL2',
'AMD1',
'TAT',
'MRI1',
'APIP',
'MTR',
'SRM',
'SDSL',
'IL4I1',
'LDHC',
'CBS',
'LDHB',
'LDHA',
'MAT2B',
'MAT2A',
'MDH1',
'ENOPH1'],
'Phenylalanine, tyrosine and tryptophan biosynthesis Homo sapiens hsa00400': ['IL4I1',
'GOT2',
'GOT1',
'PAH',
'TAT'],
'Phenylalanine metabolism Homo sapiens hsa00360': ['AOC2',
'DDC',
'AOC3',
'GOT2',
'MAOB',
'GOT1',
'MAOA',
'TAT',
'MIF',
'GLYAT',
'IL4I1',
'ALDH1A3',
'ALDH3B2',
'ALDH3A1',
'PAH',
'ALDH3B1',
'HPD'],
'Tyrosine metabolism Homo sapiens hsa00350': ['FAHD1',
'AOC2',
'AOC3',
'GOT2',
'HGD',
'GOT1',
'MIF',
'FAH',
'TYR',
'GSTZ1',
'TH',
'DCT',
'ALDH1A3',
'ALDH3A1',
'HPD',
'PNMT',
'DDC',
'TYRP1',
'MAOB',
'ADH1C',
'MAOA',
'ADH1B',
'TAT',
'ADH1A',
'DBH',
'COMT',
'ADH6',
'ADH7',
'IL4I1',
'ADH4',
'ADH5',
'TPO',
'ALDH3B2',
'ALDH3B1',
'AOX1'],
'Ubiquinone and other terpenoid-quinone biosynthesis Homo sapiens hsa00130': ['COQ5',
'NQO1',
'VKORC1L1',
'COQ3',
'COQ2',
'VKORC1',
'GGCX',
'TAT',
'HPD',
'COQ7',
'COQ6'],
'Terpenoid backbone biosynthesis Homo sapiens hsa00900': ['NUS1',
'FDPS',
'IDI1',
'MVK',
'IDI2',
'ICMT',
'HMGCS2',
'HMGCS1',
'GGPS1',
'ACAT1',
'HMGCR',
'DHDDS',
'ZMPSTE24',
'ACAT2',
'FNTB',
'PMVK',
'FNTA',
'RCE1',
'PDSS2',
'PDSS1',
'MVD',
'PCYOX1'],
'Synthesis and degradation of ketone bodies Homo sapiens hsa00072': ['HMGCL',
'HMGCLL1',
'OXCT1',
'HMGCS2',
'BDH2',
'OXCT2',
'HMGCS1',
'BDH1',
'ACAT1',
'ACAT2'],
'Butanoate metabolism Homo sapiens hsa00650': ['HMGCS2',
'HMGCS1',
'GAD2',
'GAD1',
'ALDH5A1',
'BDH2',
'BDH1',
'HADHA',
'L2HGDH',
'HMGCLL1',
'ACSM4',
'ACSM3',
'ACSM1',
'ACSM2A',
'ACAT1',
'ACSM2B',
'EHHADH',
'ACSM6',
'ACSM5',
'ECHS1',
'ABAT',
'ACAT2',
'HMGCL',
'AACS',
'OXCT1',
'OXCT2',
'HADH',
'ACADS'],
'Valine, leucine and isoleucine degradation Homo sapiens hsa00280': ['BCKDHB',
'ACAD8',
'BCKDHA',
'HMGCS2',
'HMGCS1',
'MCCC1',
'MCCC2',
'ACADSB',
'MUT',
'ACSF3',
'ALDH3A2',
'HADHB',
'ALDH7A1',
'ALDH6A1',
'PCCB',
'PCCA',
'HADHA',
'IVD',
'AGXT2',
'DLD',
'BCAT2',
'ALDH9A1',
'BCAT1',
'HMGCLL1',
'HIBADH',
'ACAT1',
'EHHADH',
'ECHS1',
'ABAT',
'HSD17B10',
'ACAT2',
'IL4I1',
'HMGCL',
'AACS',
'MCEE',
'AUH',
'OXCT1',
'DBT',
'ACADM',
'ALDH1B1',
'ALDH2',
'OXCT2',
'AOX1',
'ACAA2',
'HADH',
'HIBCH',
'ACAA1',
'ACADS'],
'Propanoate metabolism Homo sapiens hsa00640': ['BCKDHB',
'BCKDHA',
'MUT',
'ALDH6A1',
'PCCB',
'SUCLA2',
'PCCA',
'HADHA',
'ECHDC1',
'SUCLG2',
'DLD',
'SUCLG1',
'LDHAL6A',
'LDHAL6B',
'ACSS3',
'ACAT1',
'EHHADH',
'ECHS1',
'ABAT',
'ACACB',
'ACAT2',
'ACACA',
'MCEE',
'LDHC',
'LDHB',
'LDHA',
'DBT',
'ACADM',
'MLYCD',
'ACSS2',
'HIBCH',
'ACSS1'],
'beta-Alanine metabolism Homo sapiens hsa00410': ['AOC2',
'AOC3',
'SMOX',
'GAD2',
'GAD1',
'UPB1',
'ALDH3A2',
'ALDH7A1',
'ALDH6A1',
'HADHA',
'DPYD',
'ALDH1A3',
'ALDH3A1',
'SMS',
'ALDH9A1',
'DPYS',
'GADL1',
'EHHADH',
'SRM',
'ECHS1',
'CNDP1',
'ABAT',
'CNDP2',
'ACADM',
'ALDH1B1',
'ALDH2',
'ALDH3B2',
'ALDH3B1',
'CARNS1',
'MLYCD',
'HIBCH'],
'Histidine metabolism Homo sapiens hsa00340': ['DDC',
'MAOB',
'AOC1',
'MAOA',
'HDC',
'UROC1',
'C9ORF41',
'CNDP1',
'HNMT',
'CNDP2',
'FTCD',
'ALDH3A2',
'ALDH7A1',
'HAL',
'AMDHD1',
'ALDH1B1',
'ALDH2',
'ALDH1A3',
'ALDH3B2',
'ALDH3A1',
'ALDH3B1',
'CARNS1',
'ALDH9A1',
'ASPA'],
'Arginine and proline metabolism Homo sapiens hsa00330': ['GAMT',
'CKM',
'AOC1',
'CKMT1B',
'CKMT1A',
'PYCR1',
'PYCR2',
'PRODH2',
'DAO',
'ALDH4A1',
'P4HA1',
'P4HA2',
'LAP3',
'P4HA3',
'ALDH18A1',
'PYCRL',
'MAOB',
'MAOA',
'AMD1',
'ODC1',
'CNDP1',
'CNDP2',
'L3HYPDH',
'NOS3',
'GOT2',
'SMOX',
'ARG1',
'GOT1',
'ARG2',
'AGMAT',
'AZIN2',
'ALDH3A2',
'ALDH7A1',
'GATM',
'HOGA1',
'LOC102724788',
'SMS',
'ALDH9A1',
'OAT',
'SAT1',
'SRM',
'SAT2',
'CKMT2',
'ALDH1B1',
'ALDH2',
'CKB',
'CARNS1',
'NOS1',
'NOS2',
'PRODH'],
'Tryptophan metabolism Homo sapiens hsa00380': ['AADAT',
'AOC1',
'INMT',
'KMO',
'ALDH3A2',
'ALDH7A1',
'CAT',
'HADHA',
'CYP1A2',
'CYP1A1',
'ALDH9A1',
'IDO1',
'GCDH',
'IDO2',
'OGDH',
'TPH2',
'DDC',
'TPH1',
'MAOB',
'MAOA',
'ASMT',
'HAAO',
'ACMSD',
'CCBL2',
'ACAT1',
'CCBL1',
'EHHADH',
'ECHS1',
'ACAT2',
'IL4I1',
'AANAT',
'TDO2',
'ALDH1B1',
'ALDH2',
'OGDHL',
'AFMID',
'KYNU',
'AOX1',
'CYP1B1',
'HADH'],
'Lysine degradation Homo sapiens hsa00310': ['AASS',
'SETD1A',
'SETDB2',
'SETDB1',
'PHYKPL',
'BBOX1',
'SETD1B',
'ASH1L',
'TMLHE',
'PLOD1',
'DOT1L',
'SUV39H2',
'SUV39H1',
'ACAT1',
'DLST',
'EHHADH',
'PLOD3',
'PLOD2',
'ECHS1',
'ACAT2',
'NSD1',
'PIPOX',
'WHSC1L1',
'AADAT',
'CAMKMT',
'SETMAR',
'ALDH3A2',
'ALDH7A1',
'HADHA',
'ALDH9A1',
'GCDH',
'OGDH',
'KMT2E',
'KMT2B',
'WHSC1',
'KMT2A',
'KMT2D',
'SETD7',
'KMT2C',
'SETD8',
'EHMT1',
'EHMT2',
'SUV420H1',
'SUV420H2',
'HYKK',
'ALDH1B1',
'ALDH2',
'OGDHL',
'COLGALT1',
'HADH',
'SETD2',
'COLGALT2'],
'Fatty acid elongation Homo sapiens hsa00062': ['ELOVL1',
'ELOVL2',
'MECR',
'ELOVL5',
'ELOVL6',
'ELOVL3',
'ELOVL4',
'ELOVL7',
'HADHB',
'HADHA',
'TECR',
'PPT2',
'ACOT2',
'PTPLAD1',
'PPT1',
'ACOT1',
'PTPLAD2',
'ACOT7',
'ACOT4',
'ECHS1',
'HSD17B12',
'PTPLA',
'PTPLB',
'ACAA2',
'HADH'],
'Biosynthesis of unsaturated fatty acids Homo sapiens hsa01040': ['ELOVL2',
'ELOVL5',
'ELOVL6',
'SCD5',
'PECR',
'HSD17B12',
'PTPLA',
'BAAT',
'PTPLB',
'SCD',
'ACOX3',
'HADHA',
'ACOX1',
'TECR',
'ACOT2',
'PTPLAD1',
'ACOT1',
'PTPLAD2',
'ACOT7',
'ACAA1',
'FADS2',
'ACOT4',
'FADS1'],
'Fatty acid metabolism Homo sapiens hsa01212': ['ELOVL2',
'CPT1B',
'MECR',
'CPT1A',
'ACSL3',
'ELOVL5',
'ELOVL6',
'ACSL1',
'SCD5',
'OXSM',
'ACSL6',
'ACADSB',
'ACSL5',
'ACSL4',
'MCAT',
'CPT1C',
'HADHB',
'SCD',
'ACOX3',
'FASN',
'HADHA',
'ACOX1',
'TECR',
'PPT2',
'PTPLAD1',
'PPT1',
'ACSBG2',
'PTPLAD2',
'ACSBG1',
'ACADVL',
'PECR',
'ACAT1',
'EHHADH',
'ECHS1',
'HSD17B12',
'PTPLA',
'ACAT2',
'ACACA',
'PTPLB',
'ACADM',
'ACADL',
'CPT2',
'ACAA2',
'HADH',
'ACAA1',
'ACADS',
'FADS2',
'FADS1'],
'Fatty acid degradation Homo sapiens hsa00071': ['CPT1B',
'CPT1A',
'ACSL3',
'CYP4A11',
'ACSL1',
'ACSL6',
'ACADSB',
'ACSL5',
'ACSL4',
'CPT1C',
'ALDH3A2',
'HADHB',
'ALDH7A1',
'ACOX3',
'HADHA',
'ACOX1',
'ACSBG2',
'ACSBG1',
'ALDH9A1',
'GCDH',
'ACADVL',
'ADH1C',
'ECI1',
'CYP4A22',
'ADH1B',
'ECI2',
'ADH1A',
'ACAT1',
'EHHADH',
'ECHS1',
'ADH6',
'ACAT2',
'ADH7',
'ADH4',
'ADH5',
'ACADM',
'ALDH1B1',
'ALDH2',
'ACADL',
'CPT2',
'ACAA2',
'HADH',
'ACAA1',
'ACADS'],
'Fatty acid biosynthesis Homo sapiens hsa00061': ['ACSL3',
'ACSL1',
'OLAH',
'OXSM',
'ACSL6',
'ACSL5',
'ACSL4',
'MCAT',
'ACACB',
'ACACA',
'FASN',
'ACSBG2',
'ACSBG1'],
'PPAR signaling pathway Homo sapiens hsa03320': ['GK',
'MMP1',
'HMGCS2',
'ACSL3',
'ACSL1',
'APOA2',
'ACSL6',
'APOA5',
'ACSL5',
'ACSL4',
'SCD',
'ACOX3',
'ACOX2',
'ACOX1',
'APOA1',
'SLC27A2',
'SLC27A1',
'ILK',
'AQP7',
'EHHADH',
'UCP1',
'DBI',
'CYP7A1',
'RXRA',
'PLTP',
'RXRB',
'CPT2',
'ME1',
'RXRG',
'PCK2',
'CD36',
'PCK1',
'ADIPOQ',
'CPT1B',
'PPARA',
'CPT1A',
'PLIN1',
'PDPK1',
'NR1H3',
'SCD5',
'SORBS1',
'CYP8B1',
'CPT1C',
'FABP2',
'CYP27A1',
'FABP3',
'FABP4',
'FABP5',
'FABP6',
'FABP7',
'APOC3',
'ANGPTL4',
'PPARG',
'ACSBG2',
'ACSBG1',
'SLC27A4',
'PPARD',
'SLC27A6',
'SLC27A5',
'FABP1',
'LPL',
'GK2',
'ACADM',
'UBC',
'ACADL',
'SCP2',
'ACAA1',
'OLR1',
'FADS2'],
'Primary bile acid biosynthesis Homo sapiens hsa00120': ['HSD3B7',
'ACOT8',
'AKR1D1',
'HSD17B4',
'AKR1C4',
'CYP7B1',
'CYP46A1',
'CYP8B1',
'CYP7A1',
'CH25H',
'BAAT',
'CYP39A1',
'CYP27A1',
'AMACR',
'ACOX2',
'SCP2',
'SLC27A5'],
'Peroxisome Homo sapiens hsa04146': ['PEX19',
'ACOT8',
'PHYH',
'ACSL3',
'ACSL1',
'ECH1',
'PEX1',
'ACSL6',
'PEX10',
'ACSL5',
'PEX3',
'ACSL4',
'PEX12',
'PEX2',
'PEX13',
'PEX14',
'PEX16',
'DAO',
'PEX5L',
'ACOX3',
'PEX5',
'ACOX2',
'ACOX1',
'PEX7',
'PXMP2',
'PEX6',
'PXMP4',
'FAR1',
'FAR2',
'PEX11G',
'PAOX',
'CRAT',
'HMGCLL1',
'SLC27A2',
'PEX11A',
'PEX11B',
'HSD17B4',
'MPV17L2',
'EHHADH',
'CROT',
'PEX26',
'PMVK',
'PIPOX',
'HAO2',
'HAO1',
'IDH1',
'GSTK1',
'IDH2',
'EPHX2',
'DHRS4',
'SOD1',
'BAAT',
'SOD2',
'SLC25A17',
'AMACR',
'CAT',
'GNPAT',
'AGPS',
'AGXT',
'MVK',
'ABCD3',
'ABCD4',
'PECR',
'MPV17L',
'ECI2',
'NUDT7',
'DDO',
'NUDT12',
'HMGCL',
'PRDX5',
'SCP2',
'PRDX1',
'NUDT19',
'MLYCD',
'XDH',
'MPV17',
'NOS2',
'HACL1',
'ABCD1',
'DHRS4L1',
'ACAA1',
'ABCD2',
'DECR2'],
'Spliceosome Homo sapiens hsa03040': ['ISY1-RAB43',
'PPIL1',
'HSPA1L',
'ALYREF',
'CWC15',
'CRNKL1',
'CHERP',
'WBP11',
'HNRNPM',
'PHF5A',
'SNRPA',
'RBMXL3',
'HNRNPK',
'DDX39B',
'RBMXL2',
'SRSF3',
'HSPA1A',
'SRSF4',
'HNRNPC',
'SNRPF',
'SNRNP27',
'SRSF5',
'SNRPG',
'PPIH',
'SRSF6',
'SRSF7',
'SNRPE',
'SRSF8',
'PPIE',
'SRSF9',
'SNRPB',
'SNRPC',
'HSPA1B',
'RNU6-1',
'SF3B5',
'SF3B6',
'SF3B3',
'SF3B4',
'SRSF1',
'SRSF2',
'HNRNPU',
'RBMXL1',
'EFTUD2',
'MAGOH',
'SNRPD3',
'SNRPD2',
'SNRPD1',
'DHX38',
'SF3B1',
'TXNL4A',
'SF3B2',
'AQR',
'PRPF38B',
'PRPF38A',
'BUD31',
'LSM2',
'LSM6',
'LSM5',
'LSM4',
'LSM3',
'PRPF6',
'PRPF8',
'LSM8',
'SNW1',
'LSM7',
'PRPF4',
'PRPF3',
'HNRNPA1L2',
'SNRNP200',
'TCERG1',
'DDX5',
'PCBP1',
'ZMAT2',
'SNRNP70',
'DHX15',
'DHX16',
'CCDC12',
'RBM17',
'NCBP2',
'HSPA6',
'HSPA8',
'NCBP1',
'CDC5L',
'HSPA2',
'PRPF40B',
'PRPF40A',
'MAGOHB',
'PRPF18',
'PRPF19',
'NHP2L1',
'SYF2',
'SLU7',
'RBM25',
'RBM22',
'DHX8',
'USP39',
'RBM8A',
'DDX46',
'DDX42',
'PQBP1',
'U2AF1L4',
'PLRG1',
'CTNNBL1',
'BCAS2',
'SF3A2',
'SF3A3',
'THOC2',
'THOC1',
'THOC3',
'CDC40',
'U2SURP',
'XAB2',
'SNRNP40',
'PRPF31',
'ACIN1',
'SNRPA1',
'RP9',
'RBMX',
'SF3A1',
'EIF4A3',
'ISY1',
'DDX23',
'U2AF2',
'U2AF1',
'LOC102724594',
'SART1',
'TRA2A',
'PUF60',
'TRA2B',
'SNRPB2',
'SRSF10',
'HNRNPA3',
'SMNDC1',
'HNRNPA1'],
'RNA degradation Homo sapiens hsa03018': ['HSPA9',
'PNPT1',
'DIS3',
'PABPC5',
'CNOT10',
'CNOT6',
'CNOT7',
'CNOT8',
'CNOT1',
'XRN2',
'CNOT2',
'XRN1',
'CNOT3',
'CNOT4',
'PABPC3',
'PABPC4',
'PABPC1',
'DCP1B',
'DCP1A',
'MPHOSPH6',
'BTG4',
'ZCCHC7',
'BTG3',
'BTG2',
'BTG1',
'PARN',
'TOB2',
'TOB1',
'EXOSC8',
'EXOSC7',
'EXOSC6',
'EXOSC10',
'EXOSC5',
'DHX36',
'EXOSC9',
'PABPC1L2A',
'PABPC1L2B',
'EXOSC4',
'EXOSC3',
'EXOSC2',
'EXOSC1',
'TTC37',
'CNOT6L',
'PATL1',
'LSM2',
'LSM1',
'PAPD5',
'LSM6',
'LSM5',
'LSM4',
'LSM3',
'PAN3',
'PAN2',
'LSM8',
'PFKM',
'LSM7',
'PFKL',
'C1D',
'WDR61',
'PAPD7',
'RQCD1',
'PABPC1L',
'SKIV2L',
'DCP2',
'SKIV2L2',
'PFKP',
'DDX6',
'DIS3L',
'ENO1',
'ENO2',
'HSPD1',
'ENO3',
'EDC3',
'EDC4',
'NUDT16',
'DCPS',
'PABPC4L'],
'mRNA surveillance pathway Homo sapiens hsa03015': ['CPSF6',
'UPF2',
'UPF1',
'CPSF7',
'NCBP2',
'CPSF2',
'CPSF1',
'PABPC5',
'CPSF4',
'NCBP1',
'ALYREF',
'CPSF3',
'PPP2R5C',
'PPP2R5B',
'UPF3B',
'PPP2R1A',
'PPP2R5E',
'UPF3A',
'PPP2R5D',
'SRRM1',
'WDR33',
'PPP2R5A',
'PPP1CA',
'MAGOHB',
'PPP1CB',
'DDX39B',
'WDR82',
'SSU72',
'PABPC3',
'PABPC4',
'ETF1',
'PABPC1',
'WIBG',
'DAZAP1',
'RNMT',
'HBS1L',
'RBM8A',
'CASC3',
'PNN',
'MAGOH',
'NXF1',
'PPP1CC',
'NXF2',
'NXF3',
'PCF11',
'CLP1',
'PABPN1',
'SAP18',
'PABPC1L2A',
'SYMPK',
'PABPC1L2B',
'NXF5',
'BCL2L2-PABPN1',
'RNGTT',
'PPP2R3A',
'PPP2R3C',
'PPP2R3B',
'PPP2CA',
'NUDT21',
'PPP2R2D',
'PPP2R2C',
'RNPS1',
'ACIN1',
'PABPC1L',
'NXF2B',
'EIF4A3',
'SMG5',
'NXT1',
'NXT2',
'SMG1',
'CSTF3',
'MSI1',
'MSI2',
'PPP2R2B',
'PPP2R2A',
'PABPN1L',
'CSTF2T',
'GSPT2',
'SMG6',
'GSPT1',
'SMG7',
'PPP2CB',
'PELO',
'FIP1L1',
'PPP2R1B',
'PAPOLG',
'CSTF2',
'PAPOLB',
'CSTF1',
'PAPOLA',
'PABPC4L'],
'RNA transport Homo sapiens hsa03013': ['UBE2I',
'EIF1AY',
'EIF1AX',
'NUP214',
'ALYREF',
'UPF3B',
'NUP210',
'UPF3A',
'SRRM1',
'RPP25L',
'EEF1A2',
'NUP93',
'EEF1A1',
'NUP210L',
'DDX39B',
'NUP98',
'CLNS1A',
'RPP21',
'POP1',
'EIF1B',
'RPP25',
'RAN',
'RNU6-1',
'NUP205',
'CYFIP2',
'RGPD1',
'CYFIP1',
'GEMIN2',
'GEMIN4',
'CASC3',
'RGPD8',
'RGPD3',
'RGPD2',
'NUP160',
'RGPD5',
'PNN',
'RGPD4',
'MAGOH',
'NXF1',
'NXF2',
'NXF3',
'NUP85',
'TGS1',
'SAP18',
'PABPC1L2A',
'NUP88',
'PABPC1L2B',
'RAE1',
'NXF5',
'RPP14',
'EIF2B5',
'SNUPN',
'EIF2B4',
'EIF2B3',
'RPP40',
'NUP153',
'NUP155',
'EIF2S3',
'EIF2S2',
'EIF1',
'EIF2S1',
'EIF4E1B',
'EIF5',
'GEMIN5',
'EIF4G1',
'GEMIN6',
'RNPS1',
'GEMIN7',
'GEMIN8',
'EIF4G3',
'EIF4G2',
'NXF2B',
'POP7',
'POM121',
'SNORD3B-2',
'SNORD3B-1',
'FMR1',
'POP5',
'RPP30',
'POP4',
'EIF4EBP1',
'PHAX',
'LOC101929087',
'AAAS',
'TPR',
'POM121C',
'NUP62',
'EIF4EBP2',
'EIF4EBP3',
'EIF3CL',
'EIF2B2',
'EIF2B1',
'PABPC4L',
'RPP38',
'EIF5B',
'UPF2',
'UPF1',
'SEC13',
'NCBP2',
'PABPC5',
'ELAC2',
'NDC1',
'NCBP1',
'ELAC1',
'NUP133',
'MAGOHB',
'SENP2',
'NUP50',
'NUP54',
'PABPC3',
'PABPC4',
'PABPC1',
'EIF4E2',
'WIBG',
'EIF4B',
'SEH1L',
'STRAP',
'RBM8A',
'NMD3',
'SNORD3C',
'SNORD3A',
'FXR2',
'FXR1',
'NUP43',
'SMN1',
'SMN2',
'EIF4E',
'EIF3A',
'RANBP2',
'PRMT5',
'THOC2',
'THOC1',
'TRNT1',
'THOC3',
'THOC6',
'THOC5',
'THOC7',
'RANGAP1',
'KPNB1',
'XPOT',
'EIF3J',
'NUP35',
'EIF3H',
'EIF3I',
'EIF3F',
'ACIN1',
'PABPC1L',
'EIF3G',
'TACC3',
'EIF3D',
'NUPL2',
'EIF3E',
'EIF3B',
'POM121L2',
'NUPL1',
'NUP37',
'EIF3C',
'EIF4A3',
'EIF4A2',
'EIF4A1',
'NUP107',
'NXT1',
'NXT2',
'DDX20',
'NUP188',
'XPO1',
'XPO5',
'SUMO2',
'SUMO1',
'SUMO4',
'SUMO3',
'PAIP1'],
'Ribosome biogenesis in eukaryotes Homo sapiens hsa03008': ['REXO1',
'REXO2',
'IMP3',
'IMP4',
'WDR75',
'GNL3',
'GNL2',
'WDR36',
'LOC643802',
'GTPBP4',
'RPP25L',
'GNL3L',
'LSG1',
'CIRH1A',
'DKC1',
'XRN2',
'NHP2L1',
'XRN1',
'NAT10',
'POP1',
'SBDS',
'RPP25',
'NHP2',
'RAN',
'NVL',
'LOC101929627',
'NMD3',
'SPATA5',
'SNORD3C',
'SNORD3A',
'FBL',
'NOL6',
'EFTUD1',
'NXF1',
'EMG1',
'NXF2',
'NXF3',
'RRP7A',
'TCOF1',
'DROSHA',
'GAR1',
'UTP14A',
'NXF5',
'MDN1',
'UTP14C',
'NOP58',
'UTP15',
'UTP18',
'UTP6',
'RPP40',
'CSNK2A2',
'CSNK2A1',
'CSNK2A3',
'LOC81691',
'RCL1',
'TBL3',
'EIF6',
'CSNK2B',
'RNR1',
'NOP10',
'RNR2',
'NOP56',
'NXF2B',
'RBM28',
'POP7',
'SNORD3B-2',
'NXT1',
'LOC101929601',
'SNORD3B-1',
'NXT2',
'WDR3',
'MPHOSPH10',
'HEATR1',
'POP5',
'FCF1',
'RPP30',
'POP4',
'LOC100288562',
'WDR43',
'NOB1',
'AK6',
'PWP2',
'XPO1',
'BMS1',
'RIOK1',
'LOC101930111',
'RIOK2',
'RMRP',
'RPP38'],
'Ribosome Homo sapiens hsa03010': ['RPL22',
'RPS8',
'RPL21',
'RPL36A-HNRNPH2',
'RPS9',
'RPS6',
'RPL24',
'RPL23',
'RPS7',
'MRPS18C',
'MRPS18A',
'RPSA',
'FAU',
'RPL26',
'RPL28',
'RPL22L1',
'RPL27',
'RPL29',
'RPL26L1',
'RPL11',
'RPL10',
'RPL13',
'RPL12',
'RPS4Y2',
'RPS4Y1',
'RPL36AL',
'RPL15',
'RPL14',
'RPS5',
'RPL17',
'RPS2',
'RPS3',
'RPL19',
'RPL18',
'RPL41',
'LOC101929876',
'RPL3L',
'RPS27',
'RPS26',
'MRPL10',
'LOC102724828',
'RPS29',
'RPS28',
'RPL27A',
'RPS21',
'RPS20',
'RPS23',
'RNR1',
'RNR2',
'RSL24D1',
'RPS25',
'RPS24',
'RPL5',
'RPL6',
'RPL3',
'RPL31',
'RPL30',
'RPL4',
'RPL32',
'RPL35',
'MRPL19',
'RPL34',
'MRPL17',
'MRPL18',
'MRPL15',
'MRPL16',
'RPL9',
'MRPL1',
'MRPL13',
'MRPL14',
'RPL7',
'MRPL11',
'MRPL12',
'RPL8',
'MRPL20',
'RPS16',
'MRPL4',
'RPS15',
'MRPL21',
'RPS18',
'MRPL3',
'RPS17',
'MRPL2',
'MRPL9',
'RPS19',
'RPL37',
'RPL36',
'RPL39',
'RPS10',
'RPL38',
'RPS12',
'RPS11',
'RPS14',
'RPS13',
'RPL13A',
'MRPL28',
'MRPS2',
'MRPL27',
'RPS3A',
'MRPL24',
'MRPS7',
'MRPS6',
'MRPL22',
'MRPS5',
'MRPL23',
'MRPL32',
'MRPS9',
'MRPL30',
'RPL37A',
'MRPS16',
'MRPS17',
'MRPS14',
'RPS10-NUDT3',
'MRPS15',
'MRPS12',
'MRPS10',
'MRPS11',
'RPS27L',
'MRPL35',
'MRPL36',
'MRPL33',
'MRPL34',
'RPL36A',
'RPS15A',
'RPS27A',
'MRPS21',
'RPL35A',
'RPL23A',
'UBA52',
'RPLP0',
'RPL10L',
'RPLP2',
'RPLP1',
'RPL10A',
'RPS4X',
'RPL18A',
'RPL7A'],
'Folate biosynthesis Homo sapiens hsa00790': ['GCH1',
'GGH',
'ALPPL2',
'PTS',
'DHFR',
'QDPR',
'ALPP',
'FPGS',
'SPR',
'DHFRL1',
'ALPL',
'MOCS1',
'ALPI',
'MOCS2'],
'One carbon pool by folate Homo sapiens hsa00670': ['MTFMT',
'ALDH1L2',
'ALDH1L1',
'SHMT2',
'ST20-MTHFS',
'AMT',
'SHMT1',
'MTHFR',
'MTHFS',
'MTR',
'TYMS',
'DHFR',
'FTCD',
'ATIC',
'MTHFD2',
'DHFRL1',
'MTHFD2L',
'MTHFD1',
'MTHFD1L',
'GART'],
'Sulfur relay system Homo sapiens hsa04122': ['NFS1',
'CTU2',
'TRMU',
'MOCS3',
'CTU1',
'TST',
'MPST',
'URM1',
'MOCS1',
'MOCS2'],
'Sulfur metabolism Homo sapiens hsa00920': ['IMPAD1',
'TST',
'MPST',
'ETHE1',
'CYCS',
'BPNT1',
'PAPSS1',
'SQRDL',
'SUOX',
'PAPSS2'],
'Selenocompound metabolism Homo sapiens hsa00450': ['TXNRD3',
'TXNRD2',
'TXNRD1',
'MARS2',
'CCBL2',
'CCBL1',
'INMT',
'MTR',
'PAPSS1',
'SEPSECS',
'PAPSS2',
'SEPHS1',
'CTH',
'MARS',
'SCLY',
'SEPHS2',
'PSTK'],
'Aminoacyl-tRNA biosynthesis Homo sapiens hsa00970': ['HARS2',
'DARS',
'WARS',
'RARS2',
'SARS',
'SARS2',
'KARS',
'PARS2',
'GARS',
'TARS2',
'AARS',
'CARS',
'AARS2',
'TRNS2',
'TARS',
'TRNS1',
'YARS2',
'LARS',
'HARS',
'IARS2',
'YARS',
'TRNW',
'TRNV',
'TRNT',
'TRNR',
'GATB',
'TRNQ',
'MARS2',
'GATC',
'QRSL1',
'DARS2',
'WARS2',
'TRNY',
'TRNL1',
'TRNL2',
'QARS',
'LARS2',
'MARS',
'IARS',
'FARSB',
'CARS2',
'FARSA',
'MTFMT',
'TARSL2',
'VARS',
'RARS',
'EPRS',
'FARS2',
'SEPSECS',
'TRNH',
'TRNG',
'TRNF',
'TRNE',
'TRND',
'NARS2',
'TRNC',
'TRNA',
'NARS',
'TRNP',
'TRNN',
'TRNM',
'PSTK',
'TRNK',
'VARS2',
'TRNI',
'EARS2']}
In [16]:
Copied!
gene_sets
gene_sets
Out[16]:
{'HALLMARK_ADIPOGENESIS': {'ABCA1',
'ABCB8',
'ACAA2',
'ACADL',
'ACADM',
'ACADS',
'ACLY',
'ACO2',
'ACOX1',
'ADCY6',
'ADIG',
'ADIPOQ',
'ADIPOR2',
'AGPAT3',
'AIFM1',
'AK2',
'ALDH2',
'ALDOA',
'ANGPT1',
'ANGPTL4',
'APLP2',
'APOE',
'ARAF',
'ARL4A',
'ATL2',
'ATP1B3',
'ATP5PO',
'BAZ2A',
'BCKDHA',
'BCL2L13',
'BCL6',
'C3',
'CAT',
'CAVIN1',
'CAVIN2',
'CCNG2',
'CD151',
'CD302',
'CD36',
'CDKN2C',
'CHCHD10',
'CHUK',
'CIDEA',
'CMBL',
'CMPK1',
'COL15A1',
'COL4A1',
'COQ3',
'COQ5',
'COQ9',
'COX6A1',
'COX7B',
'COX8A',
'CPT2',
'CRAT',
'CS',
'CYC1',
'CYP4B1',
'DBT',
'DDT',
'DECR1',
'DGAT1',
'DHCR7',
'DHRS7',
'DHRS7B',
'DLAT',
'DLD',
'DNAJB9',
'DNAJC15',
'DRAM2',
'ECH1',
'ECHS1',
'ELMOD3',
'ELOVL6',
'ENPP2',
'EPHX2',
'ESRRA',
'ESYT1',
'ETFB',
'FABP4',
'FAH',
'FZD4',
'G3BP2',
'GADD45A',
'GBE1',
'GHITM',
'GPAM',
'GPAT4',
'GPD2',
'GPHN',
'GPX3',
'GPX4',
'GRPEL1',
'HADH',
'HIBCH',
'HSPB8',
'IDH1',
'IDH3A',
'IDH3G',
'IFNGR1',
'IMMT',
'ITGA7',
'ITIH5',
'ITSN1',
'JAGN1',
'LAMA4',
'LEP',
'LIFR',
'LIPE',
'LPCAT3',
'LPL',
'LTC4S',
'MAP4K3',
'MCCC1',
'MDH2',
'ME1',
'MGLL',
'MGST3',
'MIGA2',
'MRAP',
'MRPL15',
'MTARC2',
'MTCH2',
'MYLK',
'NABP1',
'NDUFA5',
'NDUFAB1',
'NDUFB7',
'NDUFS3',
'NKIRAS1',
'NMT1',
'OMD',
'ORM1',
'PDCD4',
'PEMT',
'PEX14',
'PFKFB3',
'PFKL',
'PGM1',
'PHLDB1',
'PHYH',
'PIM3',
'PLIN2',
'POR',
'PPARG',
'PPM1B',
'PPP1R15B',
'PRDX3',
'PREB',
'PTCD3',
'PTGER3',
'QDPR',
'RAB34',
'REEP5',
'REEP6',
'RETN',
'RETSAT',
'RIOK3',
'RMDN3',
'RNF11',
'RREB1',
'RTN3',
'SAMM50',
'SCARB1',
'SCP2',
'SDHB',
'SDHC',
'SLC19A1',
'SLC1A5',
'SLC25A1',
'SLC25A10',
'SLC27A1',
'SLC5A6',
'SLC66A3',
'SNCG',
'SOD1',
'SORBS1',
'SOWAHC',
'SPARCL1',
'SQOR',
'SSPN',
'STAT5A',
'STOM',
'SUCLG1',
'SULT1A1',
'TALDO1',
'TANK',
'TKT',
'TOB1',
'TST',
'UBC',
'UBQLN1',
'UCK1',
'UCP2',
'UQCR10',
'UQCR11',
'UQCRC1',
'UQCRQ',
'VEGFB',
'YWHAG'},
'HALLMARK_ALLOGRAFT_REJECTION': {'AARS1',
'ABCE1',
'ABI1',
'ACHE',
'ACVR2A',
'AKT1',
'APBB1',
'B2M',
'BCAT1',
'BCL10',
'BCL3',
'BRCA1',
'C2',
'CAPG',
'CARTPT',
'CCL11',
'CCL13',
'CCL19',
'CCL2',
'CCL22',
'CCL4',
'CCL5',
'CCL7',
'CCND2',
'CCND3',
'CCR1',
'CCR2',
'CCR5',
'CD1D',
'CD2',
'CD247',
'CD28',
'CD3D',
'CD3E',
'CD3G',
'CD4',
'CD40',
'CD40LG',
'CD47',
'CD7',
'CD74',
'CD79A',
'CD80',
'CD86',
'CD8A',
'CD8B',
'CD96',
'CDKN2A',
'CFP',
'CRTAM',
'CSF1',
'CSK',
'CTSS',
'CXCL13',
'CXCL9',
'CXCR3',
'DARS1',
'DEGS1',
'DYRK3',
'EGFR',
'EIF3A',
'EIF3D',
'EIF3J',
'EIF4G3',
'EIF5A',
'ELANE',
'ELF4',
'EREG',
'ETS1',
'F2',
'F2R',
'FAS',
'FASLG',
'FCGR2B',
'FGR',
'FLNA',
'FYB1',
'GALNT1',
'GBP2',
'GCNT1',
'GLMN',
'GPR65',
'GZMA',
'GZMB',
'HCLS1',
'HDAC9',
'HIF1A',
'HLA-A',
'HLA-DMA',
'HLA-DMB',
'HLA-DOA',
'HLA-DOB',
'HLA-DQA1',
'HLA-DRA',
'HLA-E',
'HLA-G',
'ICAM1',
'ICOSLG',
'IFNAR2',
'IFNG',
'IFNGR1',
'IFNGR2',
'IGSF6',
'IKBKB',
'IL10',
'IL11',
'IL12A',
'IL12B',
'IL12RB1',
'IL13',
'IL15',
'IL16',
'IL18',
'IL18RAP',
'IL1B',
'IL2',
'IL27RA',
'IL2RA',
'IL2RB',
'IL2RG',
'IL4',
'IL4R',
'IL6',
'IL7',
'IL9',
'INHBA',
'INHBB',
'IRF4',
'IRF7',
'IRF8',
'ITGAL',
'ITGB2',
'ITK',
'JAK2',
'KLRD1',
'KRT1',
'LCK',
'LCP2',
'LIF',
'LTB',
'LY75',
'LY86',
'LYN',
'MAP3K7',
'MAP4K1',
'MBL2',
'MMP9',
'MRPL3',
'MTIF2',
'NCF4',
'NCK1',
'NCR1',
'NLRP3',
'NME1',
'NOS2',
'NPM1',
'PF4',
'PRF1',
'PRKCB',
'PRKCG',
'PSMB10',
'PTPN6',
'PTPRC',
'RARS1',
'RIPK2',
'RPL39',
'RPL3L',
'RPL9',
'RPS19',
'RPS3A',
'RPS9',
'SIT1',
'SOCS1',
'SOCS5',
'SPI1',
'SRGN',
'ST8SIA4',
'STAB1',
'STAT1',
'STAT4',
'TAP1',
'TAP2',
'TAPBP',
'TGFB1',
'TGFB2',
'THY1',
'TIMP1',
'TLR1',
'TLR2',
'TLR3',
'TLR6',
'TNF',
'TPD52',
'TRAF2',
'TRAT1',
'UBE2D1',
'UBE2N',
'WARS1',
'WAS',
'ZAP70'},
'HALLMARK_ANDROGEN_RESPONSE': {'ABCC4',
'ABHD2',
'ACSL3',
'ACTN1',
'ADAMTS1',
'ADRM1',
'AKAP12',
'AKT1',
'ALDH1A3',
'ANKH',
'APPBP2',
'ARID5B',
'AZGP1',
'B2M',
'B4GALT1',
'BMPR1B',
'CAMKK2',
'CCND1',
'CCND3',
'CDC14B',
'CDK6',
'CENPN',
'DBI',
'DHCR24',
'DNAJB9',
'ELK4',
'ELL2',
'ELOVL5',
'FADS1',
'FKBP5',
'GNAI3',
'GPD1L',
'GSR',
'GUCY1A1',
'H1-0',
'HERC3',
'HMGCR',
'HMGCS1',
'HOMER2',
'HPGD',
'HSD17B14',
'IDI1',
'INPP4B',
'INSIG1',
'IQGAP2',
'ITGAV',
'KLK2',
'KLK3',
'KRT19',
'KRT8',
'LIFR',
'LMAN1',
'MAF',
'MAK',
'MAP7',
'MERTK',
'MYL12A',
'NCOA4',
'NDRG1',
'NGLY1',
'NKX3-1',
'PA2G4',
'PDLIM5',
'PGM3',
'PIAS1',
'PLPP1',
'PMEPA1',
'PTK2B',
'PTPN21',
'RAB4A',
'RPS6KA3',
'RRP12',
'SAT1',
'SCD',
'SEC24D',
'SELENOP',
'SGK1',
'SLC26A2',
'SLC38A2',
'SMS',
'SORD',
'SPCS3',
'SPDEF',
'SRF',
'SRP19',
'STEAP4',
'STK39',
'TARP',
'TMEM50A',
'TMPRSS2',
'TNFAIP8',
'TPD52',
'TSC22D1',
'UAP1',
'UBE2I',
'UBE2J1',
'VAPA',
'XRCC5',
'XRCC6',
'ZBTB10',
'ZMIZ1'},
'HALLMARK_ANGIOGENESIS': {'APOH',
'APP',
'CCND2',
'COL3A1',
'COL5A2',
'CXCL6',
'FGFR1',
'FSTL1',
'ITGAV',
'JAG1',
'JAG2',
'KCNJ8',
'LPL',
'LRPAP1',
'LUM',
'MSX1',
'NRP1',
'OLR1',
'PDGFA',
'PF4',
'PGLYRP1',
'POSTN',
'PRG2',
'PTK2',
'S100A4',
'SERPINA5',
'SLCO2A1',
'SPP1',
'STC1',
'THBD',
'TIMP1',
'TNFRSF21',
'VAV2',
'VCAN',
'VEGFA',
'VTN'},
'HALLMARK_APICAL_JUNCTION': {'ACTA1',
'ACTB',
'ACTC1',
'ACTG1',
'ACTG2',
'ACTN1',
'ACTN2',
'ACTN3',
'ACTN4',
'ADAM15',
'ADAM23',
'ADAM9',
'ADAMTS5',
'ADRA1B',
'AKT2',
'AKT3',
'ALOX15B',
'AMH',
'AMIGO1',
'AMIGO2',
'ARHGEF6',
'ARPC2',
'ATP1A3',
'B4GALT1',
'BAIAP2',
'BMP1',
'CADM2',
'CADM3',
'CALB2',
'CAP1',
'CD209',
'CD274',
'CD276',
'CD34',
'CD86',
'CD99',
'CDH1',
'CDH11',
'CDH15',
'CDH3',
'CDH4',
'CDH6',
'CDH8',
'CDK8',
'CDSN',
'CERCAM',
'CLDN11',
'CLDN14',
'CLDN15',
'CLDN18',
'CLDN19',
'CLDN4',
'CLDN5',
'CLDN6',
'CLDN7',
'CLDN8',
'CLDN9',
'CNN2',
'CNTN1',
'COL16A1',
'COL17A1',
'COL9A1',
'CRAT',
'CRB3',
'CTNNA1',
'CTNND1',
'CX3CL1',
'DHX16',
'DLG1',
'DMP1',
'DSC1',
'DSC3',
'EGFR',
'EPB41L2',
'EVL',
'EXOC4',
'FBN1',
'FLNC',
'FSCN1',
'FYB1',
'GAMT',
'GNAI1',
'GNAI2',
'GRB7',
'GTF2F1',
'HADH',
'HRAS',
'ICAM1',
'ICAM2',
'ICAM4',
'ICAM5',
'IKBKG',
'INPPL1',
'INSIG1',
'IRS1',
'ITGA10',
'ITGA2',
'ITGA3',
'ITGA9',
'ITGB1',
'ITGB4',
'JAM3',
'JUP',
'KCNH2',
'KRT31',
'LAMA3',
'LAMB3',
'LAMC2',
'LAYN',
'LDLRAP1',
'LIMA1',
'MADCAM1',
'MAP3K20',
'MAP4K2',
'MAPK11',
'MAPK13',
'MAPK14',
'MDK',
'MMP2',
'MMP9',
'MPZL1',
'MPZL2',
'MSN',
'MVD',
'MYH10',
'MYH9',
'MYL12B',
'MYL9',
'NECTIN1',
'NECTIN2',
'NECTIN3',
'NECTIN4',
'NEGR1',
'NEXN',
'NF1',
'NF2',
'NFASC',
'NHERF4',
'NLGN2',
'NLGN3',
'NRAP',
'NRTN',
'NRXN2',
'PALS1',
'PARD6G',
'PARVA',
'PBX2',
'PCDH1',
'PECAM1',
'PFN1',
'PIK3CB',
'PIK3R3',
'PKD1',
'PLCG1',
'PPP2R2C',
'PTEN',
'PTK2',
'PTPRC',
'RAC2',
'RASA1',
'RHOF',
'RRAS',
'RSU1',
'SDC3',
'SGCE',
'SHC1',
'SHROOM2',
'SIRPA',
'SKAP2',
'SLC30A3',
'SLIT2',
'SORBS3',
'SPEG',
'SRC',
'STX4',
'SYK',
'SYMPK',
'TAOK2',
'TGFBI',
'THBS3',
'THY1',
'TIAL1',
'TJP1',
'TMEM8B',
'TNFRSF11B',
'TRAF1',
'TRO',
'TSC1',
'TSPAN4',
'TUBG1',
'VASP',
'VAV2',
'VCAM1',
'VCAN',
'VCL',
'VWF',
'WASL',
'WNK4',
'YWHAH',
'ZYX'},
'HALLMARK_APICAL_SURFACE': {'ADAM10',
'ADIPOR2',
'AFAP1L2',
'AKAP7',
'APP',
'ATP6V0A4',
'ATP8B1',
'B4GALT1',
'BRCA1',
'CD160',
'CROCC',
'CRYBG1',
'CX3CL1',
'DCBLD2',
'EFNA5',
'EPHB4',
'FLOT2',
'GAS1',
'GATA3',
'GHRL',
'GSTM3',
'HSPB1',
'IL2RB',
'IL2RG',
'LYN',
'LYPD3',
'MAL',
'MDGA1',
'NCOA6',
'NTNG1',
'PCSK9',
'PKHD1',
'PLAUR',
'RHCG',
'RTN4RL1',
'SCUBE1',
'SHROOM2',
'SLC22A12',
'SLC2A4',
'SLC34A3',
'SRPX',
'SULF2',
'THY1',
'TMEM8B'},
'HALLMARK_APOPTOSIS': {'ADD1',
'AIFM3',
'ANKH',
'ANXA1',
'APP',
'ATF3',
'AVPR1A',
'BAX',
'BCAP31',
'BCL10',
'BCL2L1',
'BCL2L10',
'BCL2L11',
'BCL2L2',
'BGN',
'BID',
'BIK',
'BIRC3',
'BMF',
'BMP2',
'BNIP3L',
'BRCA1',
'BTG2',
'BTG3',
'CASP1',
'CASP2',
'CASP3',
'CASP4',
'CASP6',
'CASP7',
'CASP8',
'CASP9',
'CAV1',
'CCNA1',
'CCND1',
'CCND2',
'CD14',
'CD2',
'CD38',
'CD44',
'CD69',
'CDC25B',
'CDK2',
'CDKN1A',
'CDKN1B',
'CFLAR',
'CLU',
'CREBBP',
'CTH',
'CTNNB1',
'CYLD',
'DAP',
'DAP3',
'DCN',
'DDIT3',
'DFFA',
'DIABLO',
'DNAJA1',
'DNAJC3',
'DNM1L',
'DPYD',
'EBP',
'EGR3',
'EMP1',
'ENO2',
'ERBB2',
'ERBB3',
'EREG',
'ETF1',
'F2',
'F2R',
'FAS',
'FASLG',
'FDXR',
'FEZ1',
'GADD45A',
'GADD45B',
'GCH1',
'GNA15',
'GPX1',
'GPX3',
'GPX4',
'GSN',
'GSR',
'GSTM1',
'GUCY2D',
'H1-0',
'HGF',
'HMGB2',
'HMOX1',
'HSPB1',
'IER3',
'IFITM3',
'IFNB1',
'IFNGR1',
'IGF2R',
'IGFBP6',
'IL18',
'IL1A',
'IL1B',
'IL6',
'IRF1',
'ISG20',
'JUN',
'KRT18',
'LEF1',
'LGALS3',
'LMNA',
'LUM',
'MADD',
'MCL1',
'MGMT',
'MMP2',
'NEDD9',
'NEFH',
'PAK1',
'PDCD4',
'PDGFRB',
'PEA15',
'PLAT',
'PLCB2',
'PLPPR4',
'PMAIP1',
'PPP2R5B',
'PPP3R1',
'PPT1',
'PRF1',
'PSEN1',
'PSEN2',
'PTK2',
'RARA',
'RELA',
'RETSAT',
'RHOB',
'RHOT2',
'RNASEL',
'ROCK1',
'SAT1',
'SATB1',
'SC5D',
'SLC20A1',
'SMAD7',
'SOD1',
'SOD2',
'SPTAN1',
'SQSTM1',
'TAP1',
'TGFB2',
'TGFBR3',
'TIMP1',
'TIMP2',
'TIMP3',
'TNF',
'TNFRSF12A',
'TNFSF10',
'TOP2A',
'TSPO',
'TXNIP',
'VDAC2',
'WEE1',
'XIAP'},
'HALLMARK_BILE_ACID_METABOLISM': {'ABCA1',
'ABCA2',
'ABCA3',
'ABCA4',
'ABCA5',
'ABCA6',
'ABCA8',
'ABCA9',
'ABCD1',
'ABCD2',
'ABCD3',
'ABCG4',
'ABCG8',
'ACSL1',
'ACSL5',
'AGXT',
'AKR1D1',
'ALDH1A1',
'ALDH8A1',
'ALDH9A1',
'AMACR',
'APOA1',
'AQP9',
'AR',
'ATXN1',
'BBOX1',
'BCAR3',
'BMP6',
'CAT',
'CH25H',
'CROT',
'CYP27A1',
'CYP39A1',
'CYP46A1',
'CYP7A1',
'CYP7B1',
'CYP8B1',
'DHCR24',
'DIO1',
'DIO2',
'EFHC1',
'EPHX2',
'FADS1',
'FADS2',
'FDXR',
'GC',
'GCLM',
'GNMT',
'GNPAT',
'GSTK1',
'HACL1',
'HAO1',
'HSD17B11',
'HSD17B4',
'HSD17B6',
'HSD3B1',
'HSD3B7',
'IDH1',
'IDH2',
'IDI1',
'ISOC1',
'KLF1',
'LCK',
'LIPE',
'LONP2',
'MLYCD',
'NEDD4',
'NPC1',
'NR0B2',
'NR1H4',
'NR1I2',
'NR3C2',
'NUDT12',
'OPTN',
'PAOX',
'PECR',
'PEX1',
'PEX11A',
'PEX11G',
'PEX12',
'PEX13',
'PEX16',
'PEX19',
'PEX26',
'PEX6',
'PEX7',
'PFKM',
'PHYH',
'PIPOX',
'PNPLA8',
'PRDX5',
'PXMP2',
'RBP1',
'RETSAT',
'RXRA',
'RXRG',
'SCP2',
'SERPINA6',
'SLC22A18',
'SLC23A1',
'SLC23A2',
'SLC27A2',
'SLC27A5',
'SLC29A1',
'SLC35B2',
'SLCO1A2',
'SOAT2',
'SOD1',
'SULT1B1',
'SULT2B1',
'TFCP2L1',
'TTR'},
'HALLMARK_CHOLESTEROL_HOMEOSTASIS': {'ABCA2',
'ACAT2',
'ACSS2',
'ACTG1',
'ADH4',
'ALCAM',
'ALDOC',
'ANTXR2',
'ANXA13',
'ANXA5',
'ATF3',
'ATF5',
'ATXN2',
'AVPR1A',
'CBS',
'CD9',
'CHKA',
'CLU',
'CPEB2',
'CTNNB1',
'CXCL16',
'CYP51A1',
'DHCR7',
'EBP',
'ECH1',
'ERRFI1',
'ETHE1',
'FABP5',
'FADS2',
'FASN',
'FBXO6',
'FDFT1',
'FDPS',
'GLDC',
'GNAI1',
'GPX8',
'GSTM2',
'GUSB',
'HMGCR',
'HMGCS1',
'HSD17B7',
'IDI1',
'JAG1',
'LDLR',
'LGALS3',
'LGMN',
'LPL',
'LSS',
'MAL2',
'MVD',
'MVK',
'NFIL3',
'NIBAN1',
'NSDHL',
'PCYT2',
'PDK3',
'PLAUR',
'PLSCR1',
'PMVK',
'PNRC1',
'PPARG',
'S100A11',
'SC5D',
'SCD',
'SEMA3B',
'SQLE',
'SREBF2',
'STARD4',
'STX5',
'TM7SF2',
'TMEM97',
'TNFRSF12A',
'TP53INP1',
'TRIB3'},
'HALLMARK_COAGULATION': {'A2M',
'ACOX2',
'ADAM9',
'ANG',
'ANXA1',
'APOA1',
'APOC1',
'APOC2',
'APOC3',
'ARF4',
'BMP1',
'C1QA',
'C1R',
'C1S',
'C2',
'C3',
'C8A',
'C8B',
'C8G',
'C9',
'CAPN2',
'CAPN5',
'CASP9',
'CD9',
'CFB',
'CFD',
'CFH',
'CFI',
'CLU',
'COMP',
'CPB2',
'CPN1',
'CPQ',
'CRIP2',
'CSRP1',
'CTSB',
'CTSE',
'CTSH',
'CTSK',
'CTSO',
'CTSV',
'DCT',
'DPP4',
'DUSP14',
'DUSP6',
'F10',
'F11',
'F12',
'F13B',
'F2',
'F2RL2',
'F3',
'F8',
'F9',
'FBN1',
'FGA',
'FGG',
'FN1',
'FURIN',
'FYN',
'GDA',
'GNB2',
'GNG12',
'GP1BA',
'GP9',
'GSN',
'HMGCS2',
'HNF4A',
'HPN',
'HRG',
'HTRA1',
'ISCU',
'ITGA2',
'ITGB3',
'ITIH1',
'KLF7',
'KLK8',
'KLKB1',
'LAMP2',
'LEFTY2',
'LGMN',
'LRP1',
'LTA4H',
'MAFF',
'MASP2',
'MBL2',
'MEP1A',
'MMP1',
'MMP10',
'MMP11',
'MMP14',
'MMP15',
'MMP2',
'MMP3',
'MMP7',
'MMP8',
'MMP9',
'MSRB2',
'MST1',
'OLR1',
'P2RY1',
'PDGFB',
'PECAM1',
'PEF1',
'PF4',
'PLAT',
'PLAU',
'PLEK',
'PLG',
'PREP',
'PROC',
'PROS1',
'PROZ',
'PRSS23',
'RABIF',
'RAC1',
'RAPGEF3',
'RGN',
'S100A1',
'S100A13',
'SERPINA1',
'SERPINB2',
'SERPINC1',
'SERPINE1',
'SERPING1',
'SH2B2',
'SIRT2',
'SPARC',
'TF',
'TFPI2',
'THBD',
'THBS1',
'TIMP1',
'TIMP3',
'TMPRSS6',
'USP11',
'VWF',
'WDR1'},
'HALLMARK_COMPLEMENT': {'ACTN2',
'ADAM9',
'ADRA2B',
'AKAP10',
'ANG',
'ANXA5',
'APOA4',
'APOBEC3F',
'APOBEC3G',
'APOC1',
'ATOX1',
'BRPF3',
'C1QA',
'C1QC',
'C1R',
'C1S',
'C2',
'C3',
'C4BPB',
'C9',
'CA2',
'CALM1',
'CALM3',
'CASP1',
'CASP10',
'CASP3',
'CASP4',
'CASP5',
'CASP7',
'CASP9',
'CBLB',
'CCL5',
'CD36',
'CD40LG',
'CD46',
'CD55',
'CD59',
'CDA',
'CDH13',
'CDK5R1',
'CEBPB',
'CFB',
'CFH',
'CLU',
'COL4A2',
'CP',
'CPM',
'CPQ',
'CR1',
'CR2',
'CSRP1',
'CTSB',
'CTSC',
'CTSD',
'CTSH',
'CTSL',
'CTSO',
'CTSS',
'CTSV',
'CXCL1',
'DGKG',
'DGKH',
'DOCK10',
'DOCK4',
'DOCK9',
'DPP4',
'DUSP5',
'DUSP6',
'DYRK2',
'EHD1',
'ERAP2',
'F10',
'F2',
'F3',
'F5',
'F7',
'F8',
'FCER1G',
'FCN1',
'FDX1',
'FN1',
'FYN',
'GATA3',
'GCA',
'GMFB',
'GNAI2',
'GNAI3',
'GNB2',
'GNB4',
'GNG2',
'GNGT2',
'GP1BA',
'GP9',
'GPD2',
'GRB2',
'GZMA',
'GZMB',
'GZMK',
'HNF4A',
'HPCAL4',
'HSPA1A',
'HSPA5',
'IL6',
'IRF1',
'IRF2',
'IRF7',
'ITGAM',
'ITIH1',
'JAK2',
'KCNIP2',
'KCNIP3',
'KIF2A',
'KLK1',
'KLKB1',
'KYNU',
'L3MBTL4',
'LAMP2',
'LAP3',
'LCK',
'LCP2',
'LGALS3',
'LGMN',
'LIPA',
'LRP1',
'LTA4H',
'LTF',
'LYN',
'MAFF',
'ME1',
'MMP12',
'MMP13',
'MMP14',
'MMP15',
'MMP8',
'MSRB1',
'MT3',
'NOTCH4',
'OLR1',
'PCLO',
'PCSK9',
'PDGFB',
'PDP1',
'PFN1',
'PHEX',
'PIK3CA',
'PIK3CG',
'PIK3R5',
'PIM1',
'PLA2G4A',
'PLA2G7',
'PLAT',
'PLAUR',
'PLEK',
'PLG',
'PLSCR1',
'PPP2CB',
'PPP4C',
'PRCP',
'PRDM4',
'PREP',
'PRKCD',
'PRSS3',
'PRSS36',
'PSEN1',
'PSMB9',
'RABIF',
'RAF1',
'RASGRP1',
'RBSN',
'RCE1',
'RHOG',
'RNF4',
'S100A12',
'S100A13',
'S100A9',
'SCG3',
'SERPINA1',
'SERPINB2',
'SERPINC1',
'SERPINE1',
'SERPING1',
'SH2B3',
'SIRT6',
'SPOCK2',
'SRC',
'STX4',
'TFPI2',
'TIMP1',
'TIMP2',
'TMPRSS6',
'TNFAIP3',
'USP14',
'USP15',
'USP16',
'USP8',
'VCPIP1',
'WAS',
'XPNPEP1',
'ZEB1',
'ZFPM2'},
'HALLMARK_DNA_REPAIR': {'AAAS',
'ADA',
'ADCY6',
'ADRM1',
'AGO4',
'AK1',
'AK3',
'ALYREF',
'APRT',
'ARL6IP1',
'BCAM',
'BCAP31',
'BOLA2',
'BRF2',
'CANT1',
'CCNO',
'CDA',
'CETN2',
'CLP1',
'CMPK2',
'COX17',
'CSTF3',
'DAD1',
'DCTN4',
'DDB1',
'DDB2',
'DGCR8',
'DGUOK',
'DUT',
'EDF1',
'EIF1B',
'ELL',
'ELOA',
'ERCC1',
'ERCC2',
'ERCC3',
'ERCC4',
'ERCC5',
'ERCC8',
'FEN1',
'GMPR2',
'GPX4',
'GSDME',
'GTF2A2',
'GTF2B',
'GTF2F1',
'GTF2H1',
'GTF2H3',
'GTF2H5',
'GTF3C5',
'GUK1',
'HCLS1',
'HPRT1',
'IMPDH2',
'ITPA',
'LIG1',
'MPC2',
'MPG',
'MRPL40',
'NCBP2',
'NELFB',
'NELFCD',
'NELFE',
'NFX1',
'NME1',
'NME3',
'NME4',
'NPR2',
'NT5C',
'NT5C3A',
'NUDT21',
'NUDT9',
'PCNA',
'PDE4B',
'PDE6G',
'PNP',
'POLA1',
'POLA2',
'POLB',
'POLD1',
'POLD3',
'POLD4',
'POLE4',
'POLH',
'POLL',
'POLR1C',
'POLR1D',
'POLR1H',
'POLR2A',
'POLR2C',
'POLR2D',
'POLR2E',
'POLR2F',
'POLR2G',
'POLR2H',
'POLR2I',
'POLR2J',
'POLR2K',
'POLR3C',
'POLR3GL',
'POM121',
'PRIM1',
'RAD51',
'RAD52',
'RAE1',
'RALA',
'RBX1',
'REV3L',
'RFC2',
'RFC3',
'RFC4',
'RFC5',
'RNMT',
'RPA2',
'RPA3',
'RRM2B',
'SAC3D1',
'SDCBP',
'SEC61A1',
'SF3A3',
'SMAD5',
'SNAPC4',
'SNAPC5',
'SRSF6',
'SSRP1',
'STX3',
'SUPT4H1',
'SUPT5H',
'SURF1',
'TAF10',
'TAF12',
'TAF13',
'TAF1C',
'TAF6',
'TAF9',
'TARBP2',
'TK2',
'TMED2',
'TP53',
'TSG101',
'TYMS',
'UMPS',
'UPF3B',
'USP11',
'VPS28',
'VPS37B',
'VPS37D',
'XPC',
'ZNF707',
'ZWINT'},
'HALLMARK_E2F_TARGETS': {'AK2',
'ANP32E',
'ASF1A',
'ASF1B',
'ATAD2',
'AURKA',
'AURKB',
'BARD1',
'BIRC5',
'BRCA1',
'BRCA2',
'BRMS1L',
'BUB1B',
'CBX5',
'CCNB2',
'CCNE1',
'CCP110',
'CDC20',
'CDC25A',
'CDC25B',
'CDCA3',
'CDCA8',
'CDK1',
'CDK4',
'CDKN1A',
'CDKN1B',
'CDKN2A',
'CDKN2C',
'CDKN3',
'CENPE',
'CENPM',
'CHEK1',
'CHEK2',
'CIT',
'CKS1B',
'CKS2',
'CNOT9',
'CSE1L',
'CTCF',
'CTPS1',
'DCK',
'DCLRE1B',
'DCTPP1',
'DDX39A',
'DEK',
'DEPDC1',
'DIAPH3',
'DLGAP5',
'DNMT1',
'DONSON',
'DSCC1',
'DUT',
'E2F8',
'EED',
'EIF2S1',
'ESPL1',
'EXOSC8',
'EZH2',
'GINS1',
'GINS3',
'GINS4',
'GSPT1',
'H2AX',
'H2AZ1',
'HELLS',
'HMGA1',
'HMGB2',
'HMGB3',
'HMMR',
'HNRNPD',
'HUS1',
'ILF3',
'ING3',
'IPO7',
'JPT1',
'KIF18B',
'KIF22',
'KIF2C',
'KIF4A',
'KPNA2',
'LBR',
'LIG1',
'LMNB1',
'LUC7L3',
'LYAR',
'MAD2L1',
'MCM2',
'MCM3',
'MCM4',
'MCM5',
'MCM6',
'MCM7',
'MELK',
'MKI67',
'MLH1',
'MMS22L',
'MRE11',
'MSH2',
'MTHFD2',
'MXD3',
'MYBL2',
'MYC',
'NAA38',
'NAP1L1',
'NASP',
'NBN',
'NCAPD2',
'NME1',
'NOLC1',
'NOP56',
'NUDT21',
'NUP107',
'NUP153',
'NUP205',
'ORC2',
'ORC6',
'PA2G4',
'PAICS',
'PAN2',
'PCNA',
'PDS5B',
'PHF5A',
'PLK1',
'PLK4',
'PMS2',
'PNN',
'POLA2',
'POLD1',
'POLD2',
'POLD3',
'POLE',
'POLE4',
'POP7',
'PPM1D',
'PPP1R8',
'PRDX4',
'PRIM2',
'PRKDC',
'PRPS1',
'PSIP1',
'PSMC3IP',
'PTTG1',
'RACGAP1',
'RAD1',
'RAD21',
'RAD50',
'RAD51AP1',
'RAD51C',
'RAN',
'RANBP1',
'RBBP7',
'RFC1',
'RFC2',
'RFC3',
'RNASEH2A',
'RPA1',
'RPA2',
'RPA3',
'RRM2',
'SHMT1',
'SLBP',
'SMC1A',
'SMC3',
'SMC4',
'SMC6',
'SNRPB',
'SPAG5',
'SPC24',
'SPC25',
'SRSF1',
'SRSF2',
'SSRP1',
'STAG1',
'STMN1',
'SUV39H1',
'SYNCRIP',
'TACC3',
'TBRG4',
'TCF19',
'TFRC',
'TIMELESS',
'TIPIN',
'TK1',
'TMPO',
'TOP2A',
'TP53',
'TRA2B',
'TRIP13',
'TUBB',
'TUBG1',
'UBE2S',
'UBE2T',
'UBR7',
'UNG',
'USP1',
'WDR90',
'WEE1',
'XPO1',
'XRCC6',
'ZW10'},
'HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION': {'ABI3BP',
'ACTA2',
'ADAM12',
'ANPEP',
'APLP1',
'AREG',
'BASP1',
'BDNF',
'BGN',
'BMP1',
'CADM1',
'CALD1',
'CALU',
'CAP2',
'CAPG',
'CCN1',
'CCN2',
'CD44',
'CD59',
'CDH11',
'CDH2',
'CDH6',
'COL11A1',
'COL12A1',
'COL16A1',
'COL1A1',
'COL1A2',
'COL3A1',
'COL4A1',
'COL4A2',
'COL5A1',
'COL5A2',
'COL5A3',
'COL6A2',
'COL6A3',
'COL7A1',
'COL8A2',
'COLGALT1',
'COMP',
'COPA',
'CRLF1',
'CTHRC1',
'CXCL1',
'CXCL12',
'CXCL6',
'CXCL8',
'DAB2',
'DCN',
'DKK1',
'DPYSL3',
'DST',
'ECM1',
'ECM2',
'EDIL3',
'EFEMP2',
'ELN',
'EMP3',
'ENO2',
'FAP',
'FAS',
'FBLN1',
'FBLN2',
'FBLN5',
'FBN1',
'FBN2',
'FERMT2',
'FGF2',
'FLNA',
'FMOD',
'FN1',
'FOXC2',
'FSTL1',
'FSTL3',
'FUCA1',
'FZD8',
'GADD45A',
'GADD45B',
'GAS1',
'GEM',
'GJA1',
'GLIPR1',
'GPC1',
'GPX7',
'GREM1',
'HTRA1',
'ID2',
'IGFBP2',
'IGFBP3',
'IGFBP4',
'IL15',
'IL32',
'IL6',
'INHBA',
'ITGA2',
'ITGA5',
'ITGAV',
'ITGB1',
'ITGB3',
'ITGB5',
'JUN',
'LAMA1',
'LAMA2',
'LAMA3',
'LAMC1',
'LAMC2',
'LGALS1',
'LOX',
'LOXL1',
'LOXL2',
'LRP1',
'LRRC15',
'LUM',
'MAGEE1',
'MATN2',
'MATN3',
'MCM7',
'MEST',
'MFAP5',
'MGP',
'MMP1',
'MMP14',
'MMP2',
'MMP3',
'MSX1',
'MXRA5',
'MYL9',
'MYLK',
'NID2',
'NNMT',
'NOTCH2',
'NT5E',
'NTM',
'OXTR',
'P3H1',
'PCOLCE',
'PCOLCE2',
'PDGFRB',
'PDLIM4',
'PFN2',
'PLAUR',
'PLOD1',
'PLOD2',
'PLOD3',
'PMEPA1',
'PMP22',
'POSTN',
'PPIB',
'PRRX1',
'PRSS2',
'PTHLH',
'PTX3',
'PVR',
'QSOX1',
'RGS4',
'RHOB',
'SAT1',
'SCG2',
'SDC1',
'SDC4',
'SERPINE1',
'SERPINE2',
'SERPINH1',
'SFRP1',
'SFRP4',
'SGCB',
'SGCD',
'SGCG',
'SLC6A8',
'SLIT2',
'SLIT3',
'SNAI2',
'SNTB1',
'SPARC',
'SPOCK1',
'SPP1',
'TAGLN',
'TFPI2',
'TGFB1',
'TGFBI',
'TGFBR3',
'TGM2',
'THBS1',
'THBS2',
'THY1',
'TIMP1',
'TIMP3',
'TNC',
'TNFAIP3',
'TNFRSF11B',
'TNFRSF12A',
'TPM1',
'TPM2',
'TPM4',
'VCAM1',
'VCAN',
'VEGFA',
'VEGFC',
'VIM',
'WIPF1',
'WNT5A'},
'HALLMARK_ESTROGEN_RESPONSE_EARLY': {'ABAT',
'ABCA3',
'ABHD2',
'ABLIM1',
'ADCY1',
'ADCY9',
'ADD3',
'AFF1',
'AKAP1',
'ALDH3B1',
'AMFR',
'ANXA9',
'AQP3',
'AR',
'AREG',
'ARL3',
'ASB13',
'B4GALT1',
'BAG1',
'BCL11B',
'BCL2',
'BHLHE40',
'BLVRB',
'CA12',
'CALB2',
'CALCR',
'CANT1',
'CBFA2T3',
'CCN5',
'CCND1',
'CD44',
'CELSR1',
'CELSR2',
'CHPT1',
'CISH',
'CLDN7',
'CLIC3',
'CXCL12',
'CYP26B1',
'DEPTOR',
'DHCR7',
'DHRS2',
'DHRS3',
'DLC1',
'DYNLT3',
'EEIG1',
'EGR3',
'ELF1',
'ELF3',
'ELOVL2',
'ELOVL5',
'ENDOD1',
'ESRP2',
'FARP1',
'FASN',
'FCMR',
'FDFT1',
'FHL2',
'FKBP4',
'FKBP5',
'FLNB',
'FOS',
'FOXC1',
'FRK',
'GAB2',
'GFRA1',
'GJA1',
'GLA',
'GREB1',
'HES1',
'HR',
'HSPB8',
'IGF1R',
'IGFBP4',
'IL17RB',
'IL6ST',
'INHBB',
'INPP5F',
'ISG20L2',
'ITPK1',
'JAK2',
'KAZN',
'KCNK15',
'KCNK5',
'KDM4B',
'KLF10',
'KLF4',
'KLK10',
'KRT13',
'KRT15',
'KRT18',
'KRT19',
'KRT8',
'LAD1',
'LRIG1',
'MAPT',
'MAST4',
'MED13L',
'MED24',
'MICB',
'MINDY1',
'MLPH',
'MPPED2',
'MREG',
'MSMB',
'MUC1',
'MYB',
'MYBBP1A',
'MYBL1',
'MYC',
'MYOF',
'NADSYN1',
'NAV2',
'NBL1',
'NCOR2',
'NHERF1',
'NPY1R',
'NRIP1',
'NXT1',
'OLFM1',
'OLFML3',
'OPN3',
'OVOL2',
'P2RY2',
'PAPSS2',
'PDLIM3',
'PDZK1',
'PEX11A',
'PGR',
'PLAAT3',
'PMAIP1',
'PODXL',
'PPIF',
'PRSS23',
'PTGES',
'RAB17',
'RAB31',
'RAPGEFL1',
'RARA',
'RASGRP1',
'RBBP8',
'REEP1',
'RET',
'RETREG1',
'RHOBTB3',
'RHOD',
'RPS6KA2',
'RRP12',
'SCARB1',
'SCNN1A',
'SEC14L2',
'SEMA3B',
'SFN',
'SH3BP5',
'SIAH2',
'SLC16A1',
'SLC19A2',
'SLC1A1',
'SLC1A4',
'SLC22A5',
'SLC24A3',
'SLC26A2',
'SLC27A2',
'SLC2A1',
'SLC37A1',
'SLC39A6',
'SLC7A2',
'SLC7A5',
'SNX24',
'SOX3',
'STC2',
'SULT2B1',
'SVIL',
'SYBU',
'SYNGR1',
'SYT12',
'TBC1D30',
'TFAP2C',
'TFF1',
'TFF3',
'TGIF2',
'TGM2',
'THSD4',
'TIAM1',
'TIPARP',
'TJP3',
'TMEM164',
'TMPRSS3',
'TOB1',
'TPBG',
'TPD52L1',
'TSKU',
'TTC39A',
'TUBB2B',
'UGCG',
'UNC119',
'WFS1',
'WWC1',
'XBP1',
'ZNF185'},
'HALLMARK_ESTROGEN_RESPONSE_LATE': {'ABCA3',
'ABHD2',
'ACOX2',
'ADD3',
'AFF1',
'AGR2',
'ALDH3A2',
'ALDH3B1',
'AMFR',
'ANXA9',
'AREG',
'ARL3',
'ASCL1',
'ASS1',
'ATP2B4',
'BAG1',
'BATF',
'BCL2',
'BLVRB',
'BTG3',
'CA12',
'CA2',
'CACNA2D2',
'CALCR',
'CAV1',
'CCN5',
'CCNA1',
'CCND1',
'CD44',
'CD9',
'CDC20',
'CDC6',
'CDH1',
'CELSR2',
'CHPT1',
'CHST8',
'CISH',
'CKB',
'CLIC3',
'COX6C',
'CPE',
'CXCL12',
'CXCL14',
'CYP26B1',
'CYP4F11',
'DCXR',
'DHCR7',
'DHRS2',
'DLG5',
'DNAJC1',
'DNAJC12',
'DUSP2',
'DYNLT3',
'EEIG1',
'EGR3',
'ELOVL5',
'EMP2',
'ETFB',
'FABP5',
'FARP1',
'FDFT1',
'FGFR3',
'FKBP4',
'FKBP5',
'FLNB',
'FOS',
'FOXC1',
'FRK',
'GAL',
'GALE',
'GFUS',
'GINS2',
'GJB3',
'GLA',
'GPER1',
'HMGCS2',
'HOMER2',
'HPRT1',
'HR',
'HSPA4L',
'HSPB8',
'ID2',
'IDH2',
'IGFBP4',
'IGSF1',
'IL17RB',
'IL6ST',
'IMPA2',
'ISG20',
'ITPK1',
'JAK1',
'JAK2',
'KCNK5',
'KIF20A',
'KLF4',
'KLK10',
'KLK11',
'KRT13',
'KRT19',
'LAMC2',
'LARGE1',
'LLGL2',
'LSR',
'LTF',
'MAPK13',
'MAPT',
'MDK',
'MEST',
'METTL3',
'MICB',
'MOCS2',
'MYB',
'MYOF',
'NAB2',
'NBL1',
'NCOR2',
'NHERF1',
'NMU',
'NPY1R',
'NRIP1',
'NXT1',
'OLFM1',
'OPN3',
'OVOL2',
'PAPSS2',
'PCP4',
'PDCD4',
'PDLIM3',
'PDZK1',
'PERP',
'PGR',
'PKP3',
'PLAAT3',
'PLAC1',
'PLK4',
'PLXNB1',
'PPIF',
'PRKAR2B',
'PRLR',
'PRSS23',
'PTGER3',
'PTGES',
'PTPN6',
'RAB31',
'RABEP1',
'RAPGEFL1',
'RBBP8',
'RET',
'RNASEH2A',
'RPS6KA2',
'S100A9',
'SCARB1',
'SCNN1A',
'SCUBE2',
'SEMA3B',
'SERPINA1',
'SERPINA3',
'SERPINA5',
'SFN',
'SGK1',
'SIAH2',
'SLC16A1',
'SLC1A4',
'SLC22A5',
'SLC24A3',
'SLC26A2',
'SLC27A2',
'SLC29A1',
'SLC2A8',
'SLC7A5',
'SNX10',
'SORD',
'SOX3',
'ST14',
'ST6GALNAC2',
'STIL',
'SULT2B1',
'TFAP2C',
'TFF1',
'TFF3',
'TFPI2',
'TH',
'TIAM1',
'TJP3',
'TMPRSS3',
'TNNC1',
'TOB1',
'TOP2A',
'TPBG',
'TPD52L1',
'TPSAB1',
'TRIM29',
'TSPAN13',
'TST',
'UGDH',
'UNC13B',
'WFS1',
'XBP1',
'XRCC3',
'ZFP36'},
'HALLMARK_FATTY_ACID_METABOLISM': {'AADAT',
'ACAA1',
'ACAA2',
'ACADL',
'ACADM',
'ACADS',
'ACADVL',
'ACAT2',
'ACO2',
'ACOT2',
'ACOT8',
'ACOX1',
'ACSL1',
'ACSL4',
'ACSL5',
'ACSM3',
'ACSS1',
'ADH1C',
'ADH7',
'ADIPOR2',
'ADSL',
'ALAD',
'ALDH1A1',
'ALDH3A1',
'ALDH3A2',
'ALDH9A1',
'ALDOA',
'AOC3',
'APEX1',
'AQP7',
'AUH',
'BCKDHB',
'BLVRA',
'BMPR1B',
'BPHL',
'CA2',
'CA4',
'CA6',
'CBR1',
'CBR3',
'CD1D',
'CD36',
'CEL',
'CIDEA',
'CPOX',
'CPT1A',
'CPT2',
'CRAT',
'CRYZ',
'CYP1A1',
'CYP4A11',
'CYP4A22',
'D2HGDH',
'DECR1',
'DHCR24',
'DLD',
'DLST',
'ECH1',
'ECHS1',
'ECI1',
'ECI2',
'EHHADH',
'ELOVL5',
'ENO2',
'ENO3',
'EPHX1',
'ERP29',
'ETFDH',
'FABP1',
'FABP2',
'FASN',
'FH',
'FMO1',
'G0S2',
'GABARAPL1',
'GAD2',
'GAPDHS',
'GCDH',
'GLUL',
'GPD1',
'GPD2',
'GRHPR',
'GSTZ1',
'H2AZ1',
'HADH',
'HADHB',
'HAO2',
'HCCS',
'HIBCH',
'HMGCL',
'HMGCS1',
'HMGCS2',
'HPGD',
'HSD17B10',
'HSD17B11',
'HSD17B4',
'HSD17B7',
'HSDL2',
'HSP90AA1',
'HSPH1',
'IDH1',
'IDH3B',
'IDH3G',
'IDI1',
'IL4I1',
'INMT',
'KMT5A',
'LDHA',
'LGALS1',
'LTC4S',
'MAOA',
'MCEE',
'MDH1',
'MDH2',
'ME1',
'METAP1',
'MGLL',
'MIF',
'MIX23',
'MLYCD',
'NBN',
'NCAPH2',
'NSDHL',
'NTHL1',
'ODC1',
'OSTC',
'PCBD1',
'PDHA1',
'PDHB',
'PPARA',
'PRDX6',
'PSME1',
'PTPRG',
'PTS',
'RAP1GDS1',
'RDH11',
'RDH16',
'REEP6',
'RETSAT',
'S100A10',
'SDHA',
'SDHC',
'SDHD',
'SERINC1',
'SLC22A5',
'SMS',
'SUCLA2',
'SUCLG1',
'SUCLG2',
'TDO2',
'TP53INP2',
'UBE2L6',
'UGDH',
'UROD',
'UROS',
'VNN1',
'XIST',
'YWHAH'},
'HALLMARK_G2M_CHECKPOINT': {'ABL1',
'AMD1',
'ARID4A',
'ATF5',
'ATRX',
'AURKA',
'AURKB',
'BARD1',
'BCL3',
'BIRC5',
'BRCA2',
'BUB1',
'BUB3',
'CASP8AP2',
'CBX1',
'CCNA2',
'CCNB2',
'CCND1',
'CCNF',
'CCNT1',
'CDC20',
'CDC25A',
'CDC25B',
'CDC27',
'CDC45',
'CDC6',
'CDC7',
'CDK1',
'CDK4',
'CDKN1B',
'CDKN2C',
'CDKN3',
'CENPA',
'CENPE',
'CENPF',
'CHAF1A',
'CHEK1',
'CHMP1A',
'CKS1B',
'CKS2',
'CTCF',
'CUL1',
'CUL3',
'CUL4A',
'CUL5',
'DBF4',
'DDX39A',
'DKC1',
'DMD',
'DR1',
'DTYMK',
'E2F1',
'E2F2',
'E2F3',
'E2F4',
'EFNA5',
'EGF',
'ESPL1',
'EWSR1',
'EXO1',
'EZH2',
'FANCC',
'FBXO5',
'FOXN3',
'G3BP1',
'GINS2',
'GSPT1',
'H2AX',
'H2AZ1',
'H2AZ2',
'H2BC12',
'HIF1A',
'HIRA',
'HMGA1',
'HMGB3',
'HMGN2',
'HMMR',
'HNRNPD',
'HNRNPU',
'HOXC10',
'HSPA8',
'HUS1',
'ILF3',
'INCENP',
'JPT1',
'KATNA1',
'KIF11',
'KIF15',
'KIF20B',
'KIF22',
'KIF23',
'KIF2C',
'KIF4A',
'KIF5B',
'KMT5A',
'KNL1',
'KPNA2',
'KPNB1',
'LBR',
'LIG3',
'LMNB1',
'MAD2L1',
'MAP3K20',
'MAPK14',
'MARCKS',
'MCM2',
'MCM3',
'MCM5',
'MCM6',
'MEIS1',
'MEIS2',
'MKI67',
'MNAT1',
'MT2A',
'MTF2',
'MYBL2',
'MYC',
'NASP',
'NCL',
'NDC80',
'NEK2',
'NOLC1',
'NOTCH2',
'NSD2',
'NUMA1',
'NUP50',
'NUP98',
'NUSAP1',
'ODC1',
'ODF2',
'ORC5',
'ORC6',
'PAFAH1B1',
'PBK',
'PDS5B',
'PLK1',
'PLK4',
'PML',
'POLA2',
'POLE',
'POLQ',
'PRC1',
'PRIM2',
'PRMT5',
'PRPF4B',
'PTTG1',
'PTTG3P',
'PURA',
'RACGAP1',
'RAD21',
'RAD23B',
'RAD54L',
'RASAL2',
'RBL1',
'RBM14',
'RPA2',
'RPS6KA5',
'SAP30',
'SFPQ',
'SLC12A2',
'SLC38A1',
'SLC7A1',
'SLC7A5',
'SMAD3',
'SMARCC1',
'SMC1A',
'SMC2',
'SMC4',
'SNRPD1',
'SQLE',
'SRSF1',
'SRSF10',
'SRSF2',
'SS18',
'STAG1',
'STIL',
'STMN1',
'SUV39H1',
'SYNCRIP',
'TACC3',
'TENT4A',
'TFDP1',
'TGFB1',
'TLE3',
'TMPO',
'TNPO2',
'TOP1',
'TOP2A',
'TPX2',
'TRA2B',
'TRAIP',
'TROAP',
'TTK',
'UBE2C',
'UBE2S',
'UCK2',
'UPF1',
'WRN',
'XPO1',
'YTHDC1'},
'HALLMARK_GLYCOLYSIS': {'ABCB6',
'ADORA2B',
'AGL',
'AGRN',
'AK3',
'AK4',
'AKR1A1',
'ALDH7A1',
'ALDH9A1',
'ALDOA',
'ALDOB',
'ALG1',
'ANG',
'ANGPTL4',
'ANKZF1',
'ARPP19',
'ARTN',
'AURKA',
'B3GALT6',
'B3GAT1',
'B3GAT3',
'B3GNT3',
'B4GALT1',
'B4GALT2',
'B4GALT4',
'B4GALT7',
'BIK',
'BPNT1',
'CACNA1H',
'CAPN5',
'CASP6',
'CD44',
'CDK1',
'CENPA',
'CHPF',
'CHPF2',
'CHST1',
'CHST12',
'CHST2',
'CHST4',
'CHST6',
'CITED2',
'CLDN3',
'CLDN9',
'CLN6',
'COG2',
'COL5A1',
'COPB2',
'CTH',
'CXCR4',
'CYB5A',
'DCN',
'DDIT4',
'DEPDC1',
'DLD',
'DPYSL4',
'DSC2',
'ECD',
'EFNA3',
'EGFR',
'EGLN3',
'ELF3',
'ENO1',
'ENO2',
'ERO1A',
'EXT1',
'EXT2',
'FAM162A',
'FBP2',
'FKBP4',
'FUT8',
'G6PD',
'GAL3ST1',
'GALE',
'GALK1',
'GALK2',
'GAPDHS',
'GCLC',
'GFPT1',
'GFUS',
'GLCE',
'GLRX',
'GMPPA',
'GMPPB',
'GNE',
'GNPDA1',
'GOT1',
'GOT2',
'GPC1',
'GPC3',
'GPC4',
'GPR87',
'GUSB',
'GYS1',
'GYS2',
'HAX1',
'HDLBP',
'HK2',
'HMMR',
'HOMER1',
'HS2ST1',
'HS6ST2',
'HSPA5',
'IDH1',
'IDUA',
'IER3',
'IGFBP3',
'IL13RA1',
'IRS2',
'ISG20',
'KDELR3',
'KIF20A',
'KIF2A',
'LCT',
'LDHA',
'LDHC',
'LHPP',
'LHX9',
'MDH1',
'MDH2',
'ME1',
'ME2',
'MED24',
'MERTK',
'MET',
'MIF',
'MIOX',
'MPI',
'MXI1',
'NANP',
'NASP',
'NDST3',
'NDUFV3',
'NOL3',
'NSDHL',
'NT5E',
'P4HA1',
'P4HA2',
'PAM',
'PAXIP1',
'PC',
'PDK3',
'PFKFB1',
'PFKP',
'PGAM1',
'PGAM2',
'PGK1',
'PGLS',
'PGM2',
'PHKA2',
'PKM',
'PKP2',
'PLOD1',
'PLOD2',
'PMM2',
'POLR3K',
'PPFIA4',
'PPIA',
'PPP2CB',
'PRPS1',
'PSMC4',
'PYGB',
'PYGL',
'QSOX1',
'RARS1',
'RBCK1',
'RPE',
'RRAGD',
'SAP30',
'SDC1',
'SDC2',
'SDC3',
'SDHC',
'SLC16A3',
'SLC25A10',
'SLC25A13',
'SLC35A3',
'SLC37A4',
'SOD1',
'SOX9',
'SPAG4',
'SRD5A3',
'STC1',
'STC2',
'STMN1',
'TALDO1',
'TFF3',
'TGFA',
'TGFBI',
'TKTL1',
'TPBG',
'TPI1',
'TPST1',
'TXN',
'UGP2',
'VCAN',
'VEGFA',
'VLDLR',
'XYLT2',
'ZNF292'},
'HALLMARK_HEDGEHOG_SIGNALING': {'ACHE',
'ADGRG1',
'AMOT',
'CDK5R1',
'CDK6',
'CELSR1',
'CNTFR',
'CRMP1',
'DPYSL2',
'ETS2',
'GLI1',
'HEY1',
'HEY2',
'L1CAM',
'LDB1',
'MYH9',
'NF1',
'NKX6-1',
'NRCAM',
'NRP1',
'NRP2',
'OPHN1',
'PLG',
'PML',
'PTCH1',
'RASA1',
'RTN1',
'SCG2',
'SHH',
'SLIT1',
'THY1',
'TLE1',
'TLE3',
'UNC5C',
'VEGFA',
'VLDLR'},
'HALLMARK_HEME_METABOLISM': {'ABCB6',
'ABCG2',
'ACKR1',
'ACP5',
'ACSL6',
'ADD1',
'ADD2',
'ADIPOR1',
'AGPAT4',
'AHSP',
'ALAD',
'ALAS2',
'ALDH1L1',
'ALDH6A1',
'ANK1',
'AQP3',
'ARHGEF12',
'ARL2BP',
'ASNS',
'ATG4A',
'ATP6V0A1',
'BACH1',
'BCAM',
'BLVRA',
'BLVRB',
'BMP2K',
'BNIP3L',
'BPGM',
'BSG',
'BTG2',
'BTRC',
'C3',
'CA1',
'CA2',
'CAST',
'CAT',
'CCDC28A',
'CCND3',
'CDC27',
'CDR2',
'CIR1',
'CLCN3',
'CLIC2',
'CPOX',
'CROCCP2',
'CTNS',
'CTSB',
'CTSE',
'DAAM1',
'DCAF10',
'DCAF11',
'DCUN1D1',
'DMTN',
'E2F2',
'EIF2AK1',
'ELL2',
'ENDOD1',
'EPB41',
'EPB42',
'EPOR',
'ERMAP',
'EZH1',
'FBXO34',
'FBXO7',
'FBXO9',
'FECH',
'FN3K',
'FOXJ2',
'FOXO3',
'FTCD',
'GAPVD1',
'GATA1',
'GCLC',
'GCLM',
'GDE1',
'GLRX5',
'GMPS',
'GYPA',
'GYPB',
'GYPC',
'GYPE',
'H1-0',
'H4C3',
'HAGH',
'HBB',
'HBBP1',
'HBD',
'HBQ1',
'HBZ',
'HDGF',
'HEBP1',
'HMBS',
'HTATIP2',
'HTRA2',
'ICAM4',
'IGSF3',
'ISCA1',
'KAT2B',
'KDM7A',
'KEL',
'KHNYN',
'KLF1',
'KLF3',
'LAMP2',
'LMO2',
'LPIN2',
'LRP10',
'MAP2K3',
'MARCHF2',
'MARCHF8',
'MARK3',
'MBOAT2',
'MFHAS1',
'MGST3',
'MINPP1',
'MKRN1',
'MOCOS',
'MOSPD1',
'MPP1',
'MXI1',
'MYL4',
'NARF',
'NCOA4',
'NEK7',
'NFE2',
'NFE2L1',
'NNT',
'NR3C1',
'NUDT4',
'OPTN',
'OSBP2',
'P4HA2',
'PC',
'PDZK1IP1',
'PGLS',
'PICALM',
'PIGQ',
'PPOX',
'PPP2R5B',
'PRDX2',
'PSMD9',
'RAD23A',
'RANBP10',
'RAP1GAP',
'RBM38',
'RBM5',
'RCL1',
'RHAG',
'RHCE',
'RHD',
'RIOK3',
'RNF123',
'RNF19A',
'SDCBP',
'SEC14L1',
'SELENBP1',
'SIDT2',
'SLC10A3',
'SLC11A2',
'SLC22A4',
'SLC25A37',
'SLC25A38',
'SLC2A1',
'SLC30A1',
'SLC30A10',
'SLC4A1',
'SLC66A2',
'SLC6A8',
'SLC6A9',
'SLC7A11',
'SMOX',
'SNCA',
'SPTA1',
'SPTB',
'SYNJ1',
'TAL1',
'TCEA1',
'TENT5C',
'TFDP2',
'TFRC',
'TMCC2',
'TMEM9B',
'TNRC6B',
'TNS1',
'TOP1',
'TRAK2',
'TRIM10',
'TRIM58',
'TSPAN5',
'TSPO2',
'TYR',
'UBAC1',
'UCP2',
'UROD',
'UROS',
'USP15',
'VEZF1',
'XK',
'XPO7',
'YPEL5'},
'HALLMARK_HYPOXIA': {'ACKR3',
'ADM',
'ADORA2B',
'AK4',
'AKAP12',
'ALDOA',
'ALDOB',
'ALDOC',
'AMPD3',
'ANGPTL4',
'ANKZF1',
'ANXA2',
'ATF3',
'ATP7A',
'B3GALT6',
'B4GALNT2',
'BCAN',
'BCL2',
'BGN',
'BHLHE40',
'BNIP3L',
'BRS3',
'BTG1',
'CA12',
'CASP6',
'CAV1',
'CAVIN1',
'CAVIN3',
'CCN1',
'CCN2',
'CCN5',
'CCNG2',
'CDKN1A',
'CDKN1B',
'CDKN1C',
'CHST2',
'CHST3',
'CITED2',
'COL5A1',
'CP',
'CSRP2',
'CXCR4',
'DCN',
'DDIT3',
'DDIT4',
'DPYSL4',
'DTNA',
'DUSP1',
'EDN2',
'EFNA1',
'EFNA3',
'EGFR',
'ENO1',
'ENO2',
'ENO3',
'ERO1A',
'ERRFI1',
'ETS1',
'EXT1',
'F3',
'FAM162A',
'FBP1',
'FOS',
'FOSL2',
'FOXO3',
'GAA',
'GALK1',
'GAPDH',
'GAPDHS',
'GBE1',
'GCK',
'GCNT2',
'GLRX',
'GPC1',
'GPC3',
'GPC4',
'GPI',
'GRHPR',
'GYS1',
'HAS1',
'HDLBP',
'HEXA',
'HK1',
'HK2',
'HMOX1',
'HOXB9',
'HS3ST1',
'HSPA5',
'IDS',
'IER3',
'IGFBP1',
'IGFBP3',
'IL6',
'ILVBL',
'INHA',
'IRS2',
'ISG20',
'JMJD6',
'JUN',
'KDELR3',
'KDM3A',
'KIF5A',
'KLF6',
'KLF7',
'KLHL24',
'LALBA',
'LARGE1',
'LDHA',
'LDHC',
'LOX',
'LXN',
'MAFF',
'MAP3K1',
'MIF',
'MT1E',
'MT2A',
'MXI1',
'MYH9',
'NAGK',
'NCAN',
'NDRG1',
'NDST1',
'NDST2',
'NEDD4L',
'NFIL3',
'NOCT',
'NR3C1',
'P4HA1',
'P4HA2',
'PAM',
'PCK1',
'PDGFB',
'PDK1',
'PDK3',
'PFKFB3',
'PFKL',
'PFKP',
'PGAM2',
'PGF',
'PGK1',
'PGM1',
'PGM2',
'PHKG1',
'PIM1',
'PKLR',
'PKP1',
'PLAC8',
'PLAUR',
'PLIN2',
'PNRC1',
'PPARGC1A',
'PPFIA4',
'PPP1R15A',
'PPP1R3C',
'PRDX5',
'PRKCA',
'PYGM',
'RBPJ',
'RORA',
'RRAGD',
'S100A4',
'SAP30',
'SCARB1',
'SDC2',
'SDC3',
'SDC4',
'SELENBP1',
'SERPINE1',
'SIAH2',
'SLC25A1',
'SLC2A1',
'SLC2A3',
'SLC2A5',
'SLC37A4',
'SLC6A6',
'SRPX',
'STBD1',
'STC1',
'STC2',
'SULT2B1',
'TES',
'TGFB3',
'TGFBI',
'TGM2',
'TIPARP',
'TKTL1',
'TMEM45A',
'TNFAIP3',
'TPBG',
'TPD52',
'TPI1',
'TPST2',
'UGP2',
'VEGFA',
'VHL',
'VLDLR',
'WSB1',
'XPNPEP1',
'ZFP36',
'ZNF292'},
'HALLMARK_IL2_STAT5_SIGNALING': {'ABCB1',
'ADAM19',
'AGER',
'AHCY',
'AHNAK',
'AHR',
'ALCAM',
'AMACR',
'ANXA4',
'APLP1',
'ARL4A',
'BATF',
'BATF3',
'BCL2',
'BCL2L1',
'BHLHE40',
'BMP2',
'BMPR2',
'CA2',
'CAPG',
'CAPN3',
'CASP3',
'CCND2',
'CCND3',
'CCNE1',
'CCR4',
'CD44',
'CD48',
'CD79B',
'CD81',
'CD83',
'CD86',
'CDC42SE2',
'CDC6',
'CDCP1',
'CDKN1C',
'CISH',
'CKAP4',
'COCH',
'COL6A1',
'CSF1',
'CSF2',
'CST7',
'CTLA4',
'CTSZ',
'CXCL10',
'CYFIP1',
'DCPS',
'DENND5A',
'DHRS3',
'DRC1',
'ECM1',
'EEF1AKMT1',
'EMP1',
'ENO3',
'ENPP1',
'EOMES',
'ETFBKMT',
'ETV4',
'F2RL2',
'FAH',
'FGL2',
'FLT3LG',
'FURIN',
'GABARAPL1',
'GADD45B',
'GALM',
'GATA1',
'GBP4',
'GLIPR2',
'GPR65',
'GPR83',
'GPX4',
'GSTO1',
'GUCY1B1',
'HIPK2',
'HK2',
'HOPX',
'HUWE1',
'HYCC2',
'ICOS',
'IFITM3',
'IFNGR1',
'IGF1R',
'IGF2R',
'IKZF2',
'IKZF4',
'IL10',
'IL10RA',
'IL13',
'IL18R1',
'IL1R2',
'IL1RL1',
'IL2RA',
'IL2RB',
'IL3RA',
'IL4R',
'IRF4',
'IRF6',
'IRF8',
'ITGA6',
'ITGAE',
'ITGAV',
'ITIH5',
'KLF6',
'LCLAT1',
'LIF',
'LRIG1',
'LRRC8C',
'LTB',
'MAFF',
'MAP3K8',
'MAP6',
'MAPKAPK2',
'MUC1',
'MXD1',
'MYC',
'MYO1C',
'MYO1E',
'NCOA3',
'NCS1',
'NDRG1',
'NFIL3',
'NFKBIZ',
'NOP2',
'NRP1',
'NT5E',
'ODC1',
'P2RX4',
'P4HA1',
'PDCD2L',
'PENK',
'PHLDA1',
'PHTF2',
'PIM1',
'PLAGL1',
'PLEC',
'PLIN2',
'PLPP1',
'PLSCR1',
'PNP',
'POU2F1',
'PRAF2',
'PRKCH',
'PRNP',
'PTCH1',
'PTGER2',
'PTH1R',
'PTRH2',
'PUS1',
'RABGAP1L',
'RGS16',
'RHOB',
'RHOH',
'RNH1',
'RORA',
'RRAGD',
'S100A1',
'SCN9A',
'SELL',
'SELP',
'SERPINB6',
'SERPINC1',
'SH3BGRL2',
'SHE',
'SLC1A5',
'SLC29A2',
'SLC2A3',
'SLC39A8',
'SMPDL3A',
'SNX14',
'SNX9',
'SOCS1',
'SOCS2',
'SPP1',
'SPRED2',
'SPRY4',
'ST3GAL4',
'SWAP70',
'SYNGR2',
'SYT11',
'TGM2',
'TIAM1',
'TLR7',
'TNFRSF18',
'TNFRSF1B',
'TNFRSF21',
'TNFRSF4',
'TNFRSF8',
'TNFRSF9',
'TNFSF10',
'TNFSF11',
'TRAF1',
'TTC39B',
'TWSG1',
'UCK2',
'UMPS',
'WLS',
'XBP1'},
'HALLMARK_IL6_JAK_STAT3_SIGNALING': {'A2M',
'ACVR1B',
'ACVRL1',
'BAK1',
'CBL',
'CCL7',
'CCR1',
'CD14',
'CD36',
'CD38',
'CD44',
'CD9',
'CNTFR',
'CRLF2',
'CSF1',
'CSF2',
'CSF2RA',
'CSF2RB',
'CSF3R',
'CXCL1',
'CXCL10',
'CXCL11',
'CXCL13',
'CXCL3',
'CXCL9',
'DNTT',
'EBI3',
'FAS',
'GRB2',
'HAX1',
'HMOX1',
'IFNAR1',
'IFNGR1',
'IFNGR2',
'IL10RB',
'IL12RB1',
'IL13RA1',
'IL15RA',
'IL17RA',
'IL17RB',
'IL18R1',
'IL1B',
'IL1R1',
'IL1R2',
'IL2RA',
'IL2RG',
'IL3RA',
'IL4R',
'IL6',
'IL6ST',
'IL7',
'IL9R',
'INHBE',
'IRF1',
'IRF9',
'ITGA4',
'ITGB3',
'JUN',
'LEPR',
'LTB',
'LTBR',
'MAP3K8',
'MYD88',
'OSMR',
'PDGFC',
'PF4',
'PIK3R5',
'PIM1',
'PLA2G2A',
'PTPN1',
'PTPN11',
'PTPN2',
'REG1A',
'SOCS1',
'SOCS3',
'STAM2',
'STAT1',
'STAT2',
'STAT3',
'TGFB1',
'TLR2',
'TNF',
'TNFRSF12A',
'TNFRSF1A',
'TNFRSF1B',
'TNFRSF21',
'TYK2'},
'HALLMARK_INFLAMMATORY_RESPONSE': {'ABCA1',
'ABI1',
'ACVR1B',
'ACVR2A',
'ADGRE1',
'ADM',
'ADORA2B',
'ADRM1',
'AHR',
'APLNR',
'AQP9',
'ATP2A2',
'ATP2B1',
'ATP2C1',
'AXL',
'BDKRB1',
'BEST1',
'BST2',
'BTG2',
'C3AR1',
'C5AR1',
'CALCRL',
'CCL17',
'CCL2',
'CCL20',
'CCL22',
'CCL24',
'CCL5',
'CCL7',
'CCR7',
'CCRL2',
'CD14',
'CD40',
'CD48',
'CD55',
'CD69',
'CD70',
'CD82',
'CDKN1A',
'CHST2',
'CLEC5A',
'CMKLR1',
'CSF1',
'CSF3',
'CSF3R',
'CX3CL1',
'CXCL10',
'CXCL11',
'CXCL6',
'CXCL8',
'CXCL9',
'CXCR6',
'CYBB',
'DCBLD2',
'EBI3',
'EDN1',
'EIF2AK2',
'EMP3',
'EREG',
'F3',
'FFAR2',
'FPR1',
'FZD5',
'GABBR1',
'GCH1',
'GNA15',
'GNAI3',
'GP1BA',
'GPC3',
'GPR132',
'GPR183',
'HAS2',
'HBEGF',
'HIF1A',
'HPN',
'HRH1',
'ICAM1',
'ICAM4',
'ICOSLG',
'IFITM1',
'IFNAR1',
'IFNGR2',
'IL10',
'IL10RA',
'IL12B',
'IL15',
'IL15RA',
'IL18',
'IL18R1',
'IL18RAP',
'IL1A',
'IL1B',
'IL1R1',
'IL2RB',
'IL4R',
'IL6',
'IL7R',
'INHBA',
'IRAK2',
'IRF1',
'IRF7',
'ITGA5',
'ITGB3',
'ITGB8',
'KCNA3',
'KCNJ2',
'KCNMB2',
'KIF1B',
'KLF6',
'LAMP3',
'LCK',
'LCP2',
'LDLR',
'LIF',
'LPAR1',
'LTA',
'LY6E',
'LYN',
'MARCO',
'MEFV',
'MEP1A',
'MET',
'MMP14',
'MSR1',
'MXD1',
'MYC',
'NAMPT',
'NDP',
'NFKB1',
'NFKBIA',
'NLRP3',
'NMI',
'NMUR1',
'NOD2',
'NPFFR2',
'OLR1',
'OPRK1',
'OSM',
'OSMR',
'P2RX4',
'P2RX7',
'P2RY2',
'PCDH7',
'PDE4B',
'PDPN',
'PIK3R5',
'PLAUR',
'PROK2',
'PSEN1',
'PTAFR',
'PTGER2',
'PTGER4',
'PTGIR',
'PTPRE',
'PVR',
'RAF1',
'RASGRP1',
'RELA',
'RGS1',
'RGS16',
'RHOG',
'RIPK2',
'RNF144B',
'ROS1',
'RTP4',
'SCARF1',
'SCN1B',
'SELE',
'SELENOS',
'SELL',
'SEMA4D',
'SERPINE1',
'SGMS2',
'SLAMF1',
'SLC11A2',
'SLC1A2',
'SLC28A2',
'SLC31A1',
'SLC31A2',
'SLC4A4',
'SLC7A1',
'SLC7A2',
'SPHK1',
'SRI',
'STAB1',
'TACR1',
'TACR3',
'TAPBP',
'TIMP1',
'TLR1',
'TLR2',
'TLR3',
'TNFAIP6',
'TNFRSF1B',
'TNFRSF9',
'TNFSF10',
'TNFSF15',
'TNFSF9',
'TPBG',
'VIP'},
'HALLMARK_INTERFERON_ALPHA_RESPONSE': {'ADAR',
'B2M',
'BATF2',
'BST2',
'C1S',
'CASP1',
'CASP8',
'CCRL2',
'CD47',
'CD74',
'CMPK2',
'CMTR1',
'CNP',
'CSF1',
'CXCL10',
'CXCL11',
'DDX60',
'DHX58',
'EIF2AK2',
'ELF1',
'EPSTI1',
'GBP2',
'GBP4',
'GMPR',
'HELZ2',
'HERC6',
'HLA-C',
'IFI27',
'IFI30',
'IFI35',
'IFI44',
'IFI44L',
'IFIH1',
'IFIT2',
'IFIT3',
'IFITM1',
'IFITM2',
'IFITM3',
'IL15',
'IL4R',
'IL7',
'IRF1',
'IRF2',
'IRF7',
'IRF9',
'ISG15',
'ISG20',
'LAMP3',
'LAP3',
'LGALS3BP',
'LPAR6',
'LY6E',
'MOV10',
'MVB12A',
'MX1',
'NCOA7',
'NMI',
'NUB1',
'OAS1',
'OASL',
'OGFR',
'PARP12',
'PARP14',
'PARP9',
'PLSCR1',
'PNPT1',
'PROCR',
'PSMA3',
'PSMB8',
'PSMB9',
'PSME1',
'PSME2',
'RIPK2',
'RNF31',
'RSAD2',
'RTP4',
'SAMD9',
'SAMD9L',
'SELL',
'SLC25A28',
'SP110',
'STAT2',
'TAP1',
'TDRD7',
'TENT5A',
'TMEM140',
'TRAFD1',
'TRIM14',
'TRIM21',
'TRIM25',
'TRIM26',
'TRIM5',
'TXNIP',
'UBA7',
'UBE2L6',
'USP18',
'WARS1'},
'HALLMARK_INTERFERON_GAMMA_RESPONSE': {'ADAR',
'APOL6',
'ARID5B',
'ARL4A',
'AUTS2',
'B2M',
'BANK1',
'BATF2',
'BPGM',
'BST2',
'BTG1',
'C1R',
'C1S',
'CASP1',
'CASP3',
'CASP4',
'CASP7',
'CASP8',
'CCL2',
'CCL5',
'CCL7',
'CD274',
'CD38',
'CD40',
'CD69',
'CD74',
'CD86',
'CDKN1A',
'CFB',
'CFH',
'CIITA',
'CMKLR1',
'CMPK2',
'CMTR1',
'CSF2RB',
'CXCL10',
'CXCL11',
'CXCL9',
'DDX60',
'DHX58',
'EIF2AK2',
'EIF4E3',
'EPSTI1',
'FAS',
'FCGR1A',
'FGL2',
'FPR1',
'GBP4',
'GBP6',
'GCH1',
'GPR18',
'GZMA',
'HELZ2',
'HERC6',
'HIF1A',
'HLA-A',
'HLA-B',
'HLA-DMA',
'HLA-DQA1',
'HLA-DRB1',
'HLA-G',
'ICAM1',
'IDO1',
'IFI27',
'IFI30',
'IFI35',
'IFI44',
'IFI44L',
'IFIH1',
'IFIT1',
'IFIT2',
'IFIT3',
'IFITM2',
'IFITM3',
'IFNAR2',
'IL10RA',
'IL15',
'IL15RA',
'IL18BP',
'IL2RB',
'IL4R',
'IL6',
'IL7',
'IRF1',
'IRF2',
'IRF4',
'IRF5',
'IRF7',
'IRF8',
'IRF9',
'ISG15',
'ISG20',
'ISOC1',
'ITGB7',
'JAK2',
'KLRK1',
'LAP3',
'LATS2',
'LCP2',
'LGALS3BP',
'LY6E',
'LYSMD2',
'MARCHF1',
'METTL7B',
'MT2A',
'MTHFD2',
'MVP',
'MX1',
'MX2',
'MYD88',
'NAMPT',
'NCOA3',
'NFKB1',
'NFKBIA',
'NLRC5',
'NMI',
'NOD1',
'NUP93',
'OAS2',
'OAS3',
'OASL',
'OGFR',
'P2RY14',
'PARP12',
'PARP14',
'PDE4B',
'PELI1',
'PFKP',
'PIM1',
'PLA2G4A',
'PLSCR1',
'PML',
'PNP',
'PNPT1',
'PSMA2',
'PSMA3',
'PSMB10',
'PSMB2',
'PSMB8',
'PSMB9',
'PSME1',
'PSME2',
'PTGS2',
'PTPN1',
'PTPN2',
'PTPN6',
'RAPGEF6',
'RBCK1',
'RIGI',
'RIPK1',
'RIPK2',
'RNF213',
'RNF31',
'RSAD2',
'RTP4',
'SAMD9L',
'SAMHD1',
'SECTM1',
'SELP',
'SERPING1',
'SLAMF7',
'SLC25A28',
'SOCS1',
'SOCS3',
'SOD2',
'SP110',
'SPPL2A',
'SRI',
'SSPN',
'ST3GAL5',
'ST8SIA4',
'STAT1',
'STAT2',
'STAT3',
'STAT4',
'TAP1',
'TAPBP',
'TDRD7',
'TNFAIP2',
'TNFAIP3',
'TNFAIP6',
'TNFSF10',
'TOR1B',
'TRAFD1',
'TRIM14',
'TRIM21',
'TRIM25',
'TRIM26',
'TXNIP',
'UBE2L6',
'UPP1',
'USP18',
'VAMP5',
'VAMP8',
'VCAM1',
'WARS1',
'XAF1',
'XCL1',
'ZBP1',
'ZNFX1'},
'HALLMARK_KRAS_SIGNALING_DN': {'ABCB11',
'ABCG4',
'ACTC1',
'ADRA2C',
'AKR1B10',
'ALOX12B',
'AMBN',
'ARHGDIG',
'ARPP21',
'ASB7',
'ATP4A',
'ATP6V1B1',
'BARD1',
'BMPR1B',
'BRDT',
'BTG2',
'C5',
'CACNA1F',
'CACNG1',
'CALCB',
'CALML5',
'CAMK1D',
'CAPN9',
'CCDC106',
'CCNA1',
'CCR8',
'CD207',
'CD40LG',
'CD80',
'CDH16',
'CDKAL1',
'CELSR2',
'CHRNG',
'CHST2',
'CKM',
'CLDN16',
'CLDN8',
'CLPS',
'CLSTN3',
'CNTFR',
'COL2A1',
'COPZ2',
'COQ8A',
'CPA2',
'CPB1',
'CPEB3',
'CYP11B2',
'CYP39A1',
'DCC',
'DLK2',
'DTNB',
'EDAR',
'EDN1',
'EDN2',
'EFHD1',
'EGF',
'ENTPD7',
'EPHA5',
'FGF16',
'FGF22',
'FGFR3',
'FGGY',
'FSHB',
'GAMT',
'GDNF',
'GP1BA',
'GP2',
'GPR19',
'GPR3',
'GPRC5C',
'GRID2',
'GTF3C5',
'HNF1A',
'HSD11B2',
'HTR1B',
'HTR1D',
'IDUA',
'IFI44L',
'IFNG',
'IGFBP2',
'IL12B',
'IL5',
'INSL5',
'IRS4',
'ITGB1BP2',
'ITIH3',
'KCND1',
'KCNE2',
'KCNMB1',
'KCNN1',
'KCNQ2',
'KLHDC8A',
'KLK7',
'KLK8',
'KMT2D',
'KRT1',
'KRT13',
'KRT15',
'KRT4',
'KRT5',
'LFNG',
'LGALS7',
'LYPD3',
'MACROH2A2',
'MAGIX',
'MAST3',
'MEFV',
'MFSD6',
'MSH5',
'MTHFR',
'MX1',
'MYH7',
'MYO15A',
'MYOT',
'NGB',
'NOS1',
'NPHS1',
'NPY4R',
'NR4A2',
'NR6A1',
'NRIP2',
'NTF3',
'NUDT11',
'OXT',
'P2RX6',
'P2RY4',
'PAX3',
'PAX4',
'PCDHB1',
'PDCD1',
'PDE6B',
'PDK2',
'PKP1',
'PLAG1',
'PNMT',
'PRKN',
'PRODH',
'PROP1',
'PTGFR',
'PTPRJ',
'RGS11',
'RIBC2',
'RSAD2',
'RYR1',
'RYR2',
'SCGB1A1',
'SCN10A',
'SELENOP',
'SERPINA10',
'SERPINB2',
'SGK1',
'SHOX2',
'SIDT1',
'SKIL',
'SLC12A3',
'SLC16A7',
'SLC25A23',
'SLC29A3',
'SLC30A3',
'SLC38A3',
'SLC5A5',
'SLC6A14',
'SLC6A3',
'SMPX',
'SNCB',
'SNN',
'SOX10',
'SPHK2',
'SPRR3',
'SPTBN2',
'SSTR4',
'STAG3',
'SYNPO',
'TAS2R4',
'TCF7L1',
'TCL1A',
'TENM2',
'TENT5C',
'TEX15',
'TFAP2B',
'TFCP2L1',
'TFF2',
'TG',
'TGFB2',
'TGM1',
'THNSL2',
'THRB',
'TLX1',
'TNNI3',
'TSHB',
'UGT2B17',
'UPK3B',
'VPREB1',
'VPS50',
'WNT16',
'YBX2',
'YPEL1',
'ZBTB16',
'ZC2HC1C',
'ZNF112'},
'HALLMARK_KRAS_SIGNALING_UP': {'ABCB1',
'ACE',
'ADAM17',
'ADAM8',
'ADAMDEC1',
'ADGRA2',
'ADGRL4',
'AKAP12',
'AKT2',
'ALDH1A2',
'ALDH1A3',
'AMMECR1',
'ANGPTL4',
'ANKH',
'ANO1',
'ANXA10',
'APOD',
'ARG1',
'ATG10',
'AVL9',
'BIRC3',
'BMP2',
'BPGM',
'BTBD3',
'BTC',
'C3AR1',
'CA2',
'CAB39L',
'CBL',
'CBR4',
'CBX8',
'CCL20',
'CCND2',
'CCSER2',
'CD37',
'CDADC1',
'CFB',
'CFH',
'CFHR2',
'CIDEA',
'CLEC4A',
'CMKLR1',
'CPE',
'CROT',
'CSF2',
'CSF2RA',
'CTSS',
'CXCL10',
'CXCR4',
'DCBLD2',
'DNMBP',
'DOCK2',
'DUSP6',
'EMP1',
'ENG',
'EPB41L3',
'EPHB2',
'EREG',
'ERO1A',
'ETS1',
'ETV1',
'ETV4',
'ETV5',
'EVI5',
'F13A1',
'F2RL1',
'FBXO4',
'FCER1G',
'FGF9',
'FLT4',
'FUCA1',
'G0S2',
'GABRA3',
'GADD45G',
'GALNT3',
'GFPT2',
'GLRX',
'GNG11',
'GPNMB',
'GPRC5B',
'GUCY1A1',
'GYPC',
'H2BC3',
'HBEGF',
'HDAC9',
'HKDC1',
'HOXD11',
'HSD11B1',
'ID2',
'IGF2',
'IGFBP3',
'IKZF1',
'IL10RA',
'IL1B',
'IL1RL2',
'IL2RG',
'IL33',
'IL7R',
'INHBA',
'IRF8',
'ITGA2',
'ITGB2',
'ITGBL1',
'JUP',
'KCNN4',
'KIF5C',
'KLF4',
'LAPTM5',
'LAT2',
'LCP1',
'LIF',
'LY96',
'MAFB',
'MALL',
'MAP3K1',
'MAP4K1',
'MAP7',
'MMD',
'MMP10',
'MMP11',
'MMP9',
'MPZL2',
'MTMR10',
'MYCN',
'NAP1L2',
'NGF',
'NIN',
'NR0B2',
'NR1H4',
'NRP1',
'PCP4',
'PCSK1N',
'PDCD1LG2',
'PECAM1',
'PEG3',
'PIGR',
'PLAT',
'PLAU',
'PLAUR',
'PLEK2',
'PLVAP',
'PPBP',
'PPP1R15A',
'PRDM1',
'PRELID3B',
'PRKG2',
'PRRX1',
'PSMB8',
'PTBP2',
'PTCD2',
'PTGS2',
'PTPRR',
'RABGAP1L',
'RBM4',
'RBP4',
'RELN',
'RETN',
'RGS16',
'SATB1',
'SCG3',
'SCG5',
'SCN1B',
'SDCCAG8',
'SEMA3B',
'SERPINA3',
'SLPI',
'SNAP25',
'SNAP91',
'SOX9',
'SPARCL1',
'SPON1',
'SPP1',
'SPRY2',
'ST6GAL1',
'STRN',
'TFPI',
'TLR8',
'TMEM100',
'TMEM158',
'TMEM176A',
'TMEM176B',
'TNFAIP3',
'TNFRSF1B',
'TNNT2',
'TOR1AIP2',
'TPH1',
'TRAF1',
'TRIB1',
'TRIB2',
'TSPAN1',
'TSPAN13',
'TSPAN7',
'USH1C',
'USP12',
'VWA5A',
'WDR33',
'WNT7A',
'YRDC',
'ZNF277',
'ZNF639'},
'HALLMARK_MITOTIC_SPINDLE': {'ABI1',
'ABL1',
'ABR',
'ACTN4',
'AKAP13',
'ALMS1',
'ALS2',
'ANLN',
'APC',
'ARAP3',
'ARF6',
'ARFGEF1',
'ARFIP2',
'ARHGAP10',
'ARHGAP27',
'ARHGAP29',
'ARHGAP4',
'ARHGAP5',
'ARHGDIA',
'ARHGEF11',
'ARHGEF12',
'ARHGEF2',
'ARHGEF3',
'ARHGEF7',
'ARL8A',
'ATG4B',
'AURKA',
'BCAR1',
'BCL2L11',
'BCR',
'BIN1',
'BIRC5',
'BRCA2',
'BUB1',
'CAPZB',
'CCDC88A',
'CCNB2',
'CD2AP',
'CDC27',
'CDC42',
'CDC42BPA',
'CDC42EP1',
'CDC42EP2',
'CDC42EP4',
'CDK1',
'CDK5RAP2',
'CENPE',
'CENPF',
'CENPJ',
'CEP131',
'CEP192',
'CEP250',
'CEP57',
'CEP72',
'CKAP5',
'CLASP1',
'CLIP1',
'CLIP2',
'CNTRL',
'CNTROB',
'CSNK1D',
'CTTN',
'CYTH2',
'DLG1',
'DLGAP5',
'DOCK2',
'DOCK4',
'DST',
'DYNC1H1',
'DYNLL2',
'ECT2',
'EPB41',
'EPB41L2',
'ESPL1',
'EZR',
'FARP1',
'FBXO5',
'FGD4',
'FGD6',
'FLNA',
'FLNB',
'FSCN1',
'GEMIN4',
'GSN',
'HDAC6',
'HOOK3',
'INCENP',
'ITSN1',
'KATNA1',
'KATNB1',
'KIF11',
'KIF15',
'KIF1B',
'KIF20B',
'KIF22',
'KIF23',
'KIF2C',
'KIF3B',
'KIF3C',
'KIF4A',
'KIF5B',
'KIFAP3',
'KLC1',
'KNTC1',
'KPTN',
'LATS1',
'LLGL1',
'LMNB1',
'LRPPRC',
'MAP1S',
'MAP3K11',
'MAPRE1',
'MARCKS',
'MARK4',
'MID1',
'MID1IP1',
'MYH10',
'MYH9',
'MYO1E',
'MYO9B',
'NCK1',
'NCK2',
'NDC80',
'NEDD9',
'NEK2',
'NET1',
'NF1',
'NIN',
'NOTCH2',
'NUMA1',
'NUSAP1',
'OPHN1',
'PAFAH1B1',
'PALLD',
'PCGF5',
'PCM1',
'PCNT',
'PDLIM5',
'PIF1',
'PKD2',
'PLEKHG2',
'PLK1',
'PPP4R2',
'PRC1',
'PREX1',
'PXN',
'RAB3GAP1',
'RABGAP1',
'RACGAP1',
'RALBP1',
'RANBP9',
'RAPGEF5',
'RAPGEF6',
'RASA1',
'RASA2',
'RASAL2',
'RFC1',
'RHOF',
'RHOT2',
'RICTOR',
'ROCK1',
'SAC3D1',
'SASS6',
'SEPTIN9',
'SHROOM1',
'SHROOM2',
'SMC1A',
'SMC3',
'SMC4',
'SORBS2',
'SOS1',
'SPTAN1',
'SPTBN1',
'SSH2',
'STAU1',
'STK38L',
'SUN2',
'SYNPO',
'TAOK2',
'TBCD',
'TIAM1',
'TLK1',
'TOP2A',
'TPX2',
'TRIO',
'TSC1',
'TTK',
'TUBA4A',
'TUBD1',
'TUBGCP2',
'TUBGCP3',
'TUBGCP5',
'TUBGCP6',
'UXT',
'VCL',
'WASF1',
'WASF2',
'WASL',
'YWHAE'},
'HALLMARK_MTORC1_SIGNALING': {'ABCF2',
'ACACA',
'ACLY',
'ACSL3',
'ACTR2',
'ACTR3',
'ADD3',
'ADIPOR2',
'AK4',
'ALDOA',
'ARPC5L',
'ASNS',
'ATP2A2',
'ATP5MC1',
'ATP6V1D',
'AURKA',
'BCAT1',
'BHLHE40',
'BTG2',
'BUB1',
'CACYBP',
'CALR',
'CANX',
'CCNF',
'CCNG1',
'CCT6A',
'CD9',
'CDC25A',
'CDKN1A',
'CFP',
'COPS5',
'CORO1A',
'CTH',
'CTSC',
'CXCR4',
'CYB5B',
'CYP51A1',
'DAPP1',
'DDIT3',
'DDIT4',
'DDX39A',
'DHCR24',
'DHCR7',
'DHFR',
'EBP',
'EDEM1',
'EEF1E1',
'EGLN3',
'EIF2S2',
'ELOVL5',
'ELOVL6',
'ENO1',
'EPRS1',
'ERO1A',
'ETF1',
'FADS1',
'FADS2',
'FDXR',
'FGL2',
'FKBP2',
'G6PD',
'GAPDH',
'GBE1',
'GCLC',
'GGA2',
'GLA',
'GLRX',
'GMPS',
'GOT1',
'GPI',
'GSK3B',
'GSR',
'GTF2H1',
'HK2',
'HMBS',
'HMGCR',
'HMGCS1',
'HPRT1',
'HSP90B1',
'HSPA4',
'HSPA5',
'HSPA9',
'HSPD1',
'HSPE1',
'IDH1',
'IDI1',
'IFI30',
'IFRD1',
'IGFBP5',
'IMMT',
'INSIG1',
'ITGB2',
'LDHA',
'LDLR',
'LGMN',
'LTA4H',
'M6PR',
'MAP2K3',
'MCM2',
'MCM4',
'ME1',
'MLLT11',
'MTHFD2',
'MTHFD2L',
'NAMPT',
'NFIL3',
'NFKBIB',
'NFYC',
'NHERF1',
'NIBAN1',
'NMT1',
'NUFIP1',
'NUP205',
'NUPR1',
'P4HA1',
'PDAP1',
'PDK1',
'PFKL',
'PGK1',
'PGM1',
'PHGDH',
'PIK3R3',
'PITPNB',
'PLK1',
'PLOD2',
'PNO1',
'PNP',
'POLR3G',
'PPA1',
'PPIA',
'PPP1R15A',
'PRDX1',
'PSAT1',
'PSMA3',
'PSMA4',
'PSMB5',
'PSMC2',
'PSMC4',
'PSMC6',
'PSMD12',
'PSMD13',
'PSMD14',
'PSME3',
'PSMG1',
'PSPH',
'QDPR',
'RAB1A',
'RDH11',
'RIT1',
'RPA1',
'RPN1',
'RRM2',
'RRP9',
'SC5D',
'SCD',
'SDF2L1',
'SEC11A',
'SERP1',
'SERPINH1',
'SHMT2',
'SKAP2',
'SLA',
'SLC1A4',
'SLC1A5',
'SLC2A1',
'SLC2A3',
'SLC37A4',
'SLC6A6',
'SLC7A11',
'SLC7A5',
'SORD',
'SQLE',
'SQSTM1',
'SRD5A1',
'SSR1',
'STARD4',
'STC1',
'STIP1',
'SYTL2',
'TBK1',
'TCEA1',
'TES',
'TFRC',
'TM7SF2',
'TMEM97',
'TOMM40',
'TPI1',
'TRIB3',
'TUBA4A',
'TUBG1',
'TXNRD1',
'UBE2D3',
'UCHL5',
'UFM1',
'UNG',
'USO1',
'VLDLR',
'WARS1',
'XBP1',
'YKT6'},
'HALLMARK_MYC_TARGETS_V1': {'ABCE1',
'ACP1',
'AIMP2',
'AP3S1',
'APEX1',
'BUB3',
'C1QBP',
'CAD',
'CANX',
'CBX3',
'CCNA2',
'CCT2',
'CCT3',
'CCT4',
'CCT5',
'CCT7',
'CDC20',
'CDC45',
'CDK2',
'CDK4',
'CLNS1A',
'CNBP',
'COPS5',
'COX5A',
'CSTF2',
'CTPS1',
'CUL1',
'CYC1',
'DDX18',
'DDX21',
'DEK',
'DHX15',
'DUT',
'EEF1B2',
'EIF1AX',
'EIF2S1',
'EIF2S2',
'EIF3B',
'EIF3D',
'EIF3J',
'EIF4A1',
'EIF4E',
'EIF4G2',
'EIF4H',
'EPRS1',
'ERH',
'ETF1',
'EXOSC7',
'FAM120A',
'FBL',
'G3BP1',
'GLO1',
'GNL3',
'GOT2',
'GSPT1',
'H2AZ1',
'HDAC2',
'HDDC2',
'HDGF',
'HNRNPA1',
'HNRNPA2B1',
'HNRNPA3',
'HNRNPC',
'HNRNPD',
'HNRNPR',
'HNRNPU',
'HPRT1',
'HSP90AB1',
'HSPD1',
'HSPE1',
'IARS1',
'IFRD1',
'ILF2',
'IMPDH2',
'KARS1',
'KPNA2',
'KPNB1',
'LDHA',
'LSM2',
'LSM7',
'MAD2L1',
'MCM2',
'MCM4',
'MCM5',
'MCM6',
'MCM7',
'MRPL23',
'MRPL9',
'MRPS18B',
'MYC',
'NAP1L1',
'NCBP1',
'NCBP2',
'NDUFAB1',
'NHP2',
'NME1',
'NOLC1',
'NOP16',
'NOP56',
'NPM1',
'ODC1',
'ORC2',
'PA2G4',
'PABPC1',
'PABPC4',
'PCBP1',
'PCNA',
'PGK1',
'PHB1',
'PHB2',
'POLD2',
'POLE3',
'PPIA',
'PPM1G',
'PRDX3',
'PRDX4',
'PRPF31',
'PRPS2',
'PSMA1',
'PSMA2',
'PSMA4',
'PSMA6',
'PSMA7',
'PSMB2',
'PSMB3',
'PSMC4',
'PSMC6',
'PSMD1',
'PSMD14',
'PSMD3',
'PSMD7',
'PSMD8',
'PTGES3',
'PWP1',
'RACK1',
'RAD23B',
'RAN',
'RANBP1',
'RFC4',
'RNPS1',
'RPL14',
'RPL18',
'RPL22',
'RPL34',
'RPL6',
'RPLP0',
'RPS10',
'RPS2',
'RPS3',
'RPS5',
'RPS6',
'RRM1',
'RRP9',
'RSL1D1',
'RUVBL2',
'SERBP1',
'SET',
'SF3A1',
'SF3B3',
'SLC25A3',
'SMARCC1',
'SNRPA',
'SNRPA1',
'SNRPB2',
'SNRPD1',
'SNRPD2',
'SNRPD3',
'SNRPG',
'SRM',
'SRPK1',
'SRSF1',
'SRSF2',
'SRSF3',
'SRSF7',
'SSB',
'SSBP1',
'STARD7',
'SYNCRIP',
'TARDBP',
'TCP1',
'TFDP1',
'TOMM70',
'TRA2B',
'TRIM28',
'TUFM',
'TXNL4A',
'TYMS',
'U2AF1',
'UBA2',
'UBE2E1',
'UBE2L3',
'USP1',
'VBP1',
'VDAC1',
'VDAC3',
'XPO1',
'XPOT',
'XRCC6',
'YWHAE',
'YWHAQ'},
'HALLMARK_MYC_TARGETS_V2': {'AIMP2',
'BYSL',
'CBX3',
'CDK4',
'DCTPP1',
'DDX18',
'DUSP2',
'EXOSC5',
'FARSA',
'GNL3',
'GRWD1',
'HK2',
'HSPD1',
'HSPE1',
'IMP4',
'IPO4',
'LAS1L',
'MAP3K6',
'MCM4',
'MCM5',
'MPHOSPH10',
'MRTO4',
'MYBBP1A',
'MYC',
'NDUFAF4',
'NIP7',
'NOC4L',
'NOLC1',
'NOP16',
'NOP2',
'NOP56',
'NPM1',
'PA2G4',
'PES1',
'PHB1',
'PLK1',
'PLK4',
'PPAN',
'PPRC1',
'PRMT3',
'PUS1',
'RABEPK',
'RCL1',
'RRP12',
'RRP9',
'SLC19A1',
'SLC29A2',
'SORD',
'SRM',
'SUPV3L1',
'TBRG4',
'TCOF1',
'TFB2M',
'TMEM97',
'UNG',
'UTP20',
'WDR43',
'WDR74'},
'HALLMARK_MYOGENESIS': {'ABLIM1',
'ACHE',
'ACSL1',
'ACTA1',
'ACTC1',
'ACTN2',
'ACTN3',
'ADAM12',
'ADCY9',
'AEBP1',
'AGL',
'AGRN',
'AK1',
'AKT2',
'ANKRD2',
'APLNR',
'APOD',
'APP',
'ATP2A1',
'ATP6AP1',
'BAG1',
'BDKRB2',
'BHLHE40',
'BIN1',
'CACNA1H',
'CACNG1',
'CAMK2B',
'CASQ1',
'CASQ2',
'CAV3',
'CD36',
'CDH13',
'CDKN1A',
'CFD',
'CHRNA1',
'CHRNB1',
'CHRNG',
'CKB',
'CKM',
'CKMT2',
'CLU',
'CNN3',
'COL15A1',
'COL1A1',
'COL3A1',
'COL4A2',
'COL6A2',
'COL6A3',
'COX6A2',
'COX7A1',
'CRAT',
'CRYAB',
'CSRP3',
'CTF1',
'DAPK2',
'DENND2B',
'DES',
'DMD',
'DMPK',
'DTNA',
'EFS',
'EIF4A2',
'ENO3',
'EPHB3',
'ERBB3',
'FABP3',
'FDPS',
'FGF2',
'FHL1',
'FKBP1B',
'FLII',
'FOXO4',
'FST',
'FXYD1',
'GAA',
'GABARAPL2',
'GADD45B',
'GJA5',
'GNAO1',
'GPX3',
'GSN',
'HBEGF',
'HDAC5',
'HRC',
'HSPB2',
'HSPB8',
'IFRD1',
'IGF1',
'IGFBP3',
'IGFBP7',
'ITGA7',
'ITGB1',
'ITGB4',
'ITGB5',
'KCNH1',
'KCNH2',
'KIFC3',
'KLF5',
'LAMA2',
'LARGE1',
'LDB3',
'LPIN1',
'LSP1',
'MAPK12',
'MAPRE3',
'MB',
'MEF2A',
'MEF2C',
'MEF2D',
'MRAS',
'MYBPC3',
'MYBPH',
'MYF6',
'MYH1',
'MYH11',
'MYH2',
'MYH3',
'MYH4',
'MYH7',
'MYH8',
'MYH9',
'MYL1',
'MYL11',
'MYL2',
'MYL3',
'MYL4',
'MYL6B',
'MYL7',
'MYLK',
'MYO1C',
'MYOG',
'MYOM1',
'MYOM2',
'MYOZ1',
'NAV2',
'NCAM1',
'NOS1',
'NOTCH1',
'NQO1',
'OCEL1',
'PC',
'PDE4DIP',
'PDLIM7',
'PFKM',
'PGAM2',
'PICK1',
'PKIA',
'PLXNB2',
'PPFIA4',
'PPP1R3C',
'PRNP',
'PSEN2',
'PTGIS',
'PTP4A3',
'PVALB',
'PYGM',
'RB1',
'REEP1',
'RIT1',
'RYR1',
'SCD',
'SCHIP1',
'SGCA',
'SGCD',
'SGCG',
'SH2B1',
'SH3BGR',
'SIRT2',
'SLC6A8',
'SLN',
'SMTN',
'SOD3',
'SORBS1',
'SORBS3',
'SPARC',
'SPDEF',
'SPEG',
'SPHK1',
'SPTAN1',
'SSPN',
'STC2',
'SVIL',
'SYNGR2',
'TAGLN',
'TCAP',
'TEAD4',
'TGFB1',
'TNNC1',
'TNNC2',
'TNNI1',
'TNNI2',
'TNNT1',
'TNNT2',
'TNNT3',
'TPD52L1',
'TPM2',
'TPM3',
'TSC2',
'VIPR1',
'WWTR1'},
'HALLMARK_NOTCH_SIGNALING': {'APH1A',
'ARRB1',
'CCND1',
'CUL1',
'DLL1',
'DTX1',
'DTX2',
'DTX4',
'FBXW11',
'FZD1',
'FZD5',
'FZD7',
'HES1',
'HEYL',
'JAG1',
'KAT2A',
'LFNG',
'MAML2',
'NOTCH1',
'NOTCH2',
'NOTCH3',
'PPARD',
'PRKCA',
'PSEN2',
'PSENEN',
'RBX1',
'SAP30',
'SKP1',
'ST3GAL6',
'TCF7L2',
'WNT2',
'WNT5A'},
'HALLMARK_OXIDATIVE_PHOSPHORYLATION': {'ABCB7',
'ACAA1',
'ACAA2',
'ACADM',
'ACADSB',
'ACADVL',
'ACAT1',
'ACO2',
'AFG3L2',
'AIFM1',
'ALAS1',
'ALDH6A1',
'ATP1B1',
'ATP5F1A',
'ATP5F1B',
'ATP5F1C',
'ATP5F1D',
'ATP5F1E',
'ATP5MC1',
'ATP5MC2',
'ATP5MC3',
'ATP5ME',
'ATP5MF',
'ATP5MG',
'ATP5PB',
'ATP5PD',
'ATP5PF',
'ATP5PO',
'ATP6AP1',
'ATP6V0B',
'ATP6V0C',
'ATP6V0E1',
'ATP6V1C1',
'ATP6V1D',
'ATP6V1E1',
'ATP6V1F',
'ATP6V1G1',
'ATP6V1H',
'BAX',
'BCKDHA',
'BDH2',
'CASP7',
'COX10',
'COX11',
'COX15',
'COX17',
'COX4I1',
'COX5A',
'COX5B',
'COX6A1',
'COX6B1',
'COX6C',
'COX7A2',
'COX7A2L',
'COX7B',
'COX7C',
'COX8A',
'CPT1A',
'CS',
'CYB5A',
'CYB5R3',
'CYC1',
'CYCS',
'DECR1',
'DLAT',
'DLD',
'DLST',
'ECH1',
'ECHS1',
'ECI1',
'ETFA',
'ETFB',
'ETFDH',
'FDX1',
'FH',
'FXN',
'GLUD1',
'GOT2',
'GPI',
'GPX4',
'GRPEL1',
'HADHA',
'HADHB',
'HCCS',
'HSD17B10',
'HSPA9',
'HTRA2',
'IDH1',
'IDH2',
'IDH3A',
'IDH3B',
'IDH3G',
'IMMT',
'ISCA1',
'ISCU',
'LDHA',
'LDHB',
'LRPPRC',
'MAOB',
'MDH1',
'MDH2',
'MFN2',
'MGST3',
'MPC1',
'MRPL11',
'MRPL15',
'MRPL34',
'MRPL35',
'MRPS11',
'MRPS12',
'MRPS15',
'MRPS22',
'MRPS30',
'MTRF1',
'MTRR',
'MTX2',
'NDUFA1',
'NDUFA2',
'NDUFA3',
'NDUFA4',
'NDUFA5',
'NDUFA6',
'NDUFA7',
'NDUFA8',
'NDUFA9',
'NDUFAB1',
'NDUFB1',
'NDUFB2',
'NDUFB3',
'NDUFB4',
'NDUFB5',
'NDUFB6',
'NDUFB7',
'NDUFB8',
'NDUFC1',
'NDUFC2',
'NDUFS1',
'NDUFS2',
'NDUFS3',
'NDUFS4',
'NDUFS6',
'NDUFS7',
'NDUFS8',
'NDUFV1',
'NDUFV2',
'NNT',
'NQO2',
'OAT',
'OGDH',
'OPA1',
'OXA1L',
'PDHA1',
'PDHB',
'PDHX',
'PDK4',
'PDP1',
'PHB2',
'PHYH',
'PMPCA',
'POLR2F',
'POR',
'PRDX3',
'RETSAT',
'RHOT1',
'RHOT2',
'SDHA',
'SDHB',
'SDHC',
'SDHD',
'SLC25A11',
'SLC25A12',
'SLC25A20',
'SLC25A3',
'SLC25A4',
'SLC25A5',
'SLC25A6',
'SUCLA2',
'SUCLG1',
'SUPV3L1',
'SURF1',
'TCIRG1',
'TIMM10',
'TIMM13',
'TIMM17A',
'TIMM50',
'TIMM8B',
'TIMM9',
'TOMM22',
'TOMM70',
'UQCR10',
'UQCR11',
'UQCRB',
'UQCRC1',
'UQCRC2',
'UQCRFS1',
'UQCRH',
'UQCRQ',
'VDAC1',
'VDAC2',
'VDAC3'},
'HALLMARK_P53_PATHWAY': {'ABAT',
'ABCC5',
'ABHD4',
'ACVR1B',
'ADA',
'AEN',
'AK1',
'ALOX15B',
'ANKRA2',
'APAF1',
'APP',
'ATF3',
'BAIAP2',
'BAK1',
'BAX',
'BLCAP',
'BMP2',
'BTG1',
'BTG2',
'CASP1',
'CCND2',
'CCND3',
'CCNG1',
'CCNK',
'CCP110',
'CD81',
'CD82',
'CDH13',
'CDK5R1',
'CDKN1A',
'CDKN2A',
'CDKN2AIP',
'CDKN2B',
'CEBPA',
'CGRRF1',
'CLCA2',
'COQ8A',
'CSRNP2',
'CTSD',
'CTSF',
'CYFIP2',
'DCXR',
'DDB2',
'DDIT3',
'DDIT4',
'DEF6',
'DGKA',
'DNTTIP2',
'DRAM1',
'EI24',
'ELP1',
'EPHA2',
'EPHX1',
'EPS8L2',
'ERCC5',
'F2R',
'FAM162A',
'FAS',
'FBXW7',
'FDXR',
'FGF13',
'FOS',
'FOXO3',
'FUCA1',
'GADD45A',
'GLS2',
'GM2A',
'GPX2',
'H1-2',
'H2AC25',
'H2AJ',
'HBEGF',
'HDAC3',
'HEXIM1',
'HINT1',
'HMOX1',
'HRAS',
'HSPA4L',
'IER3',
'IER5',
'IFI30',
'IL1A',
'INHBB',
'IP6K2',
'IRAG2',
'IRAK1',
'ISCU',
'ITGB4',
'JAG2',
'JUN',
'KIF13B',
'KLF4',
'KLK8',
'KRT17',
'LDHB',
'LIF',
'MAPKAPK3',
'MDM2',
'MKNK2',
'MXD1',
'MXD4',
'NDRG1',
'NHLH2',
'NINJ1',
'NOL8',
'NOTCH1',
'NUDT15',
'NUPR1',
'OSGIN1',
'PCNA',
'PDGFA',
'PERP',
'PHLDA3',
'PIDD1',
'PITPNC1',
'PLK2',
'PLK3',
'PLXNB2',
'PMM1',
'POLH',
'POM121',
'PPM1D',
'PPP1R15A',
'PRKAB1',
'PRMT2',
'PROCR',
'PTPN14',
'PTPRE',
'PVT1',
'RAB40C',
'RACK1',
'RAD51C',
'RAD9A',
'RALGDS',
'RAP2B',
'RB1',
'RCHY1',
'RETSAT',
'RGS16',
'RHBDF2',
'RNF19B',
'RPL18',
'RPL36',
'RPS12',
'RPS27L',
'RRAD',
'RRP8',
'RXRA',
'S100A10',
'S100A4',
'SAT1',
'SDC1',
'SEC61A1',
'SERPINB5',
'SERTAD3',
'SESN1',
'SFN',
'SLC19A2',
'SLC35D1',
'SLC3A2',
'SLC7A11',
'SOCS1',
'SP1',
'SPHK1',
'ST14',
'STEAP3',
'STOM',
'TAP1',
'TAX1BP3',
'TCHH',
'TCN2',
'TGFA',
'TGFB1',
'TM4SF1',
'TM7SF3',
'TNFSF9',
'TNNI1',
'TOB1',
'TP53',
'TP63',
'TPD52L1',
'TPRKB',
'TRAF4',
'TRAFD1',
'TRIAP1',
'TRIB3',
'TSC22D1',
'TSPYL2',
'TXNIP',
'UPP1',
'VAMP8',
'VDR',
'VWA5A',
'WRAP73',
'WWP1',
'XPC',
'ZBTB16',
'ZFP36L1',
'ZMAT3',
'ZNF365'},
'HALLMARK_PANCREAS_BETA_CELLS': {'ABCC8',
'AKT3',
'CHGA',
'DCX',
'DPP4',
'ELP4',
'FOXA2',
'FOXO1',
'G6PC2',
'GCG',
'GCK',
'HNF1A',
'IAPP',
'INS',
'INSM1',
'ISL1',
'LMO2',
'MAFB',
'NEUROD1',
'NEUROG3',
'NKX2-2',
'NKX6-1',
'PAK3',
'PAX4',
'PAX6',
'PCSK1',
'PCSK2',
'PDX1',
'PKLR',
'SCGN',
'SEC11A',
'SLC2A2',
'SPCS1',
'SRP14',
'SRP9',
'SRPRB',
'SST',
'STXBP1',
'SYT13',
'VDR'},
'HALLMARK_PEROXISOME': {'ABCB1',
'ABCB4',
'ABCB9',
'ABCC5',
'ABCC8',
'ABCD1',
'ABCD2',
'ABCD3',
'ACAA1',
'ACOT8',
'ACOX1',
'ACSL1',
'ACSL4',
'ACSL5',
'ALB',
'ALDH1A1',
'ALDH9A1',
'ATXN1',
'BCL10',
'CACNA1B',
'CADM1',
'CAT',
'CDK7',
'CEL',
'CLN6',
'CLN8',
'CNBP',
'CRABP1',
'CRABP2',
'CRAT',
'CTBP1',
'CTPS1',
'DHCR24',
'DHRS3',
'DIO1',
'DLG4',
'ECH1',
'ECI2',
'EHHADH',
'ELOVL5',
'EPHX2',
'ERCC1',
'ERCC3',
'ESR2',
'FABP6',
'FADS1',
'FDPS',
'FIS1',
'GNPAT',
'GSTK1',
'HAO2',
'HMGCL',
'HRAS',
'HSD11B2',
'HSD17B11',
'HSD17B4',
'HSD3B7',
'IDE',
'IDH1',
'IDH2',
'IDI1',
'ISOC1',
'ITGB1BP1',
'LONP2',
'MLYCD',
'MSH2',
'MVP',
'NR1I2',
'NUDT19',
'PABPC1',
'PEX11A',
'PEX11B',
'PEX13',
'PEX14',
'PEX2',
'PEX5',
'PEX6',
'PRDX1',
'PRDX5',
'RDH11',
'RETSAT',
'RXRG',
'SCGB1A1',
'SCP2',
'SEMA3C',
'SERPINA6',
'SIAH1',
'SLC23A2',
'SLC25A17',
'SLC25A19',
'SLC25A4',
'SLC27A2',
'SLC35B2',
'SMARCC1',
'SOD1',
'SOD2',
'STS',
'SULT2B1',
'TOP2A',
'TSPO',
'TTR',
'UGT2B17',
'VPS4B',
'YWHAH'},
'HALLMARK_PI3K_AKT_MTOR_SIGNALING': {'ACACA',
'ACTR2',
'ACTR3',
'ADCY2',
'AKT1',
'AKT1S1',
'AP2M1',
'ARF1',
'ARHGDIA',
'ARPC3',
'ATF1',
'CAB39',
'CAB39L',
'CALR',
'CAMK4',
'CDK1',
'CDK2',
'CDK4',
'CDKN1A',
'CDKN1B',
'CFL1',
'CLTC',
'CSNK2B',
'CXCR4',
'DAPP1',
'DDIT3',
'DUSP3',
'E2F1',
'ECSIT',
'EGFR',
'EIF4E',
'FASLG',
'FGF17',
'FGF22',
'FGF6',
'GNA14',
'GNGT1',
'GRB2',
'GRK2',
'GSK3B',
'HRAS',
'HSP90B1',
'IL2RG',
'IL4',
'IRAK4',
'ITPR2',
'LCK',
'MAP2K3',
'MAP2K6',
'MAP3K7',
'MAPK1',
'MAPK10',
'MAPK8',
'MAPK9',
'MAPKAP1',
'MKNK1',
'MKNK2',
'MYD88',
'NCK1',
'NFKBIB',
'NGF',
'NOD1',
'PAK4',
'PDK1',
'PFN1',
'PIK3R3',
'PIKFYVE',
'PIN1',
'PITX2',
'PLA2G12A',
'PLCB1',
'PLCG1',
'PPP1CA',
'PPP2R1B',
'PRKAA2',
'PRKAG1',
'PRKAR2A',
'PRKCB',
'PTEN',
'PTPN11',
'RAC1',
'RAF1',
'RALB',
'RIPK1',
'RIT1',
'RPS6KA1',
'RPS6KA3',
'RPTOR',
'SFN',
'SLA',
'SLC2A1',
'SMAD2',
'SQSTM1',
'STAT2',
'TBK1',
'THEM4',
'TIAM1',
'TNFRSF1A',
'TRAF2',
'TRIB3',
'TSC2',
'UBE2D3',
'UBE2N',
'VAV3',
'YWHAB'},
'HALLMARK_PROTEIN_SECRETION': {'ABCA1',
'ADAM10',
'ANP32E',
'AP1G1',
'AP2B1',
'AP2M1',
'AP2S1',
'AP3B1',
'AP3S1',
'ARCN1',
'ARF1',
'ARFGAP3',
'ARFGEF1',
'ARFGEF2',
'ARFIP1',
'ATP1A1',
'ATP6V1B1',
'ATP6V1H',
'ATP7A',
'BET1',
'BNIP3',
'CAV2',
'CD63',
'CLCN3',
'CLN5',
'CLTA',
'CLTC',
'COG2',
'COPB1',
'COPB2',
'COPE',
'CTSC',
'DNM1L',
'DOP1A',
'DST',
'EGFR',
'ERGIC3',
'GALC',
'GBF1',
'GLA',
'GNAS',
'GOLGA4',
'GOSR2',
'ICA1',
'IGF2R',
'KIF1B',
'KRT18',
'LAMP2',
'LMAN1',
'M6PR',
'MAPK1',
'MON2',
'NAPA',
'NAPG',
'OCRL',
'PAM',
'PPT1',
'RAB14',
'RAB22A',
'RAB2A',
'RAB5A',
'RAB9A',
'RER1',
'RPS6KA3',
'SCAMP1',
'SCAMP3',
'SCRN1',
'SEC22B',
'SEC24D',
'SEC31A',
'SGMS1',
'SH3GL2',
'SNAP23',
'SNX2',
'SOD1',
'SSPN',
'STAM',
'STX12',
'STX16',
'STX7',
'TMED10',
'TMED2',
'TMX1',
'TOM1L1',
'TPD52',
'TSG101',
'TSPAN8',
'USO1',
'VAMP3',
'VAMP4',
'VAMP7',
'VPS45',
'VPS4B',
'YIPF6',
'YKT6',
'ZW10'},
'HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY': {'ABCC1',
'ATOX1',
'CAT',
'CDKN2D',
'EGLN2',
'ERCC2',
'FES',
'FTL',
'G6PD',
'GCLC',
'GCLM',
'GLRX',
'GLRX2',
'GPX3',
'GPX4',
'GSR',
'HHEX',
'HMOX2',
'IPCEF1',
'JUNB',
'LAMTOR5',
'LSP1',
'MBP',
'MGST1',
'MPO',
'MSRA',
'NDUFA6',
'NDUFB4',
'NDUFS2',
'NQO1',
'OXSR1',
'PDLIM1',
'PFKP',
'PRDX1',
'PRDX2',
'PRDX4',
'PRDX6',
'PRNP',
'PTPA',
'SBNO2',
'SCAF4',
'SELENOS',
'SOD1',
'SOD2',
'SRXN1',
'STK25',
'TXN',
'TXNRD1',
'TXNRD2'},
'HALLMARK_SPERMATOGENESIS': {'ACE',
'ACRBP',
'ACRV1',
'ACTL7B',
'ADAD1',
'ADAM2',
'ADCYAP1',
'AGFG1',
'AKAP4',
'ALOX15',
'ARL4A',
'ART3',
'AURKA',
'BRAF',
'BUB1',
'CAMK4',
'CCNA1',
'CCNB2',
'CCT6B',
'CDK1',
'CDKN3',
'CFTR',
'CHFR',
'CHRM4',
'CLGN',
'CLPB',
'CLVS1',
'CNIH2',
'COIL',
'CRISP2',
'CSNK2A2',
'CST8',
'DBF4',
'DCC',
'DDX25',
'DDX4',
'DMC1',
'DMRT1',
'DNAJB8',
'DPEP3',
'ELOVL3',
'EZH2',
'GAD1',
'GAPDHS',
'GFI1',
'GMCL1',
'GPR182',
'GRM8',
'GSG1',
'GSTM3',
'H1-6',
'HBZ',
'HOXB1',
'HSPA1L',
'HSPA2',
'HSPA4L',
'HTR5A',
'IDE',
'IFT88',
'IL12RB2',
'IL13RA2',
'IP6K1',
'JAM3',
'KIF2C',
'LDHC',
'LPIN1',
'MAP7',
'MAST2',
'MEP1B',
'MLF1',
'MLLT10',
'MTNR1A',
'MTOR',
'NAA11',
'NCAPH',
'NEFH',
'NEK2',
'NF2',
'NOS1',
'NPHP1',
'NPY5R',
'OAZ3',
'ODF1',
'PACRG',
'PAPOLB',
'PARP2',
'PCSK1N',
'PCSK4',
'PDHA2',
'PEBP1',
'PGK2',
'PGS1',
'PHF7',
'PHKG2',
'PIAS2',
'POMC',
'PRKAR2A',
'PRM2',
'PSMG1',
'RAD17',
'RFC4',
'RPL39L',
'SCG3',
'SCG5',
'SEPTIN4',
'SHE',
'SIRT1',
'SLC12A2',
'SLC2A5',
'SNAP91',
'SPATA6',
'STAM2',
'STRBP',
'SYCP1',
'TALDO1',
'TCP11',
'TEKT2',
'THEG',
'TKTL1',
'TLE4',
'TNNI3',
'TNP1',
'TNP2',
'TOPBP1',
'TSN',
'TSSK2',
'TTK',
'TUBA3C',
'TULP2',
'VDAC3',
'YBX2',
'ZC2HC1C',
'ZC3H14',
'ZNRF4',
'ZPBP'},
'HALLMARK_TGF_BETA_SIGNALING': {'ACVR1',
'APC',
'ARID4B',
'BCAR3',
'BMP2',
'BMPR1A',
'BMPR2',
'CDH1',
'CDK9',
'CDKN1C',
'CTNNB1',
'ENG',
'FKBP1A',
'FNTA',
'FURIN',
'HDAC1',
'HIPK2',
'ID1',
'ID2',
'ID3',
'IFNGR2',
'JUNB',
'KLF10',
'LEFTY2',
'LTBP2',
'MAP3K7',
'NCOR2',
'NOG',
'PMEPA1',
'PPM1A',
'PPP1CA',
'PPP1R15A',
'RAB31',
'RHOA',
'SERPINE1',
'SKI',
'SKIL',
'SLC20A1',
'SMAD1',
'SMAD3',
'SMAD6',
'SMAD7',
'SMURF1',
'SMURF2',
'SPTBN1',
'TGFB1',
'TGFBR1',
'TGIF1',
'THBS1',
'TJP1',
'TRIM33',
'UBE2D3',
'WWTR1',
'XIAP'},
'HALLMARK_TNFA_SIGNALING_VIA_NFKB': {'ABCA1',
'ACKR3',
'AREG',
'ATF3',
'ATP2B1',
'B4GALT1',
'B4GALT5',
'BCL2A1',
'BCL3',
'BCL6',
'BHLHE40',
'BIRC2',
'BIRC3',
'BMP2',
'BTG1',
'BTG2',
'BTG3',
'CCL2',
'CCL20',
'CCL4',
'CCL5',
'CCN1',
'CCND1',
'CCNL1',
'CCRL2',
'CD44',
'CD69',
'CD80',
'CD83',
'CDKN1A',
'CEBPB',
'CEBPD',
'CFLAR',
'CLCF1',
'CSF1',
'CSF2',
'CXCL1',
'CXCL10',
'CXCL11',
'CXCL2',
'CXCL3',
'CXCL6',
'DENND5A',
'DNAJB4',
'DRAM1',
'DUSP1',
'DUSP2',
'DUSP4',
'DUSP5',
'EDN1',
'EFNA1',
'EGR1',
'EGR2',
'EGR3',
'EHD1',
'EIF1',
'ETS2',
'F2RL1',
'F3',
'FJX1',
'FOS',
'FOSB',
'FOSL1',
'FOSL2',
'FUT4',
'G0S2',
'GADD45A',
'GADD45B',
'GCH1',
'GEM',
'GFPT2',
'GPR183',
'HBEGF',
'HES1',
'ICAM1',
'ICOSLG',
'ID2',
'IER2',
'IER3',
'IER5',
'IFIH1',
'IFIT2',
'IFNGR2',
'IL12B',
'IL15RA',
'IL18',
'IL1A',
'IL1B',
'IL23A',
'IL6',
'IL6ST',
'IL7R',
'INHBA',
'IRF1',
'IRS2',
'JAG1',
'JUN',
'JUNB',
'KDM6B',
'KLF10',
'KLF2',
'KLF4',
'KLF6',
'KLF9',
'KYNU',
'LAMB3',
'LDLR',
'LIF',
'LITAF',
'MAFF',
'MAP2K3',
'MAP3K8',
'MARCKS',
'MCL1',
'MSC',
'MXD1',
'MYC',
'NAMPT',
'NFAT5',
'NFE2L2',
'NFIL3',
'NFKB1',
'NFKB2',
'NFKBIA',
'NFKBIE',
'NINJ1',
'NR4A1',
'NR4A2',
'NR4A3',
'OLR1',
'PANX1',
'PDE4B',
'PDLIM5',
'PER1',
'PFKFB3',
'PHLDA1',
'PHLDA2',
'PLAU',
'PLAUR',
'PLEK',
'PLK2',
'PLPP3',
'PMEPA1',
'PNRC1',
'PPP1R15A',
'PTGER4',
'PTGS2',
'PTPRE',
'PTX3',
'RCAN1',
'REL',
'RELA',
'RELB',
'RHOB',
'RIGI',
'RIPK2',
'RNF19B',
'SAT1',
'SDC4',
'SERPINB2',
'SERPINB8',
'SERPINE1',
'SGK1',
'SIK1',
'SLC16A6',
'SLC2A3',
'SLC2A6',
'SMAD3',
'SNN',
'SOCS3',
'SOD2',
'SPHK1',
'SPSB1',
'SQSTM1',
'STAT5A',
'TANK',
'TAP1',
'TGIF1',
'TIPARP',
'TLR2',
'TNC',
'TNF',
'TNFAIP2',
'TNFAIP3',
'TNFAIP6',
'TNFAIP8',
'TNFRSF9',
'TNFSF9',
'TNIP1',
'TNIP2',
'TRAF1',
'TRIB1',
'TRIP10',
'TSC22D1',
'TUBB2A',
'VEGFA',
'YRDC',
'ZBTB10',
'ZC3H12A',
'ZFP36'},
'HALLMARK_UNFOLDED_PROTEIN_RESPONSE': {'ALDH18A1',
'ARFGAP1',
'ASNS',
'ATF3',
'ATF4',
'ATF6',
'ATP6V0D1',
'BAG3',
'BANF1',
'CALR',
'CCL2',
'CEBPB',
'CEBPG',
'CHAC1',
'CKS1B',
'CNOT2',
'CNOT4',
'CNOT6',
'CXXC1',
'DCP1A',
'DCP2',
'DCTN1',
'DDIT4',
'DDX10',
'DKC1',
'DNAJA4',
'DNAJB9',
'DNAJC3',
'EDC4',
'EDEM1',
'EEF2',
'EIF2AK3',
'EIF2S1',
'EIF4A1',
'EIF4A2',
'EIF4A3',
'EIF4E',
'EIF4EBP1',
'EIF4G1',
'ERN1',
'ERO1A',
'EXOC2',
'EXOSC1',
'EXOSC10',
'EXOSC2',
'EXOSC4',
'EXOSC5',
'EXOSC9',
'FKBP14',
'FUS',
'GEMIN4',
'GOSR2',
'H2AX',
'HERPUD1',
'HSP90B1',
'HSPA5',
'HSPA9',
'HYOU1',
'IARS1',
'IFIT1',
'IGFBP1',
'IMP3',
'KDELR3',
'KHSRP',
'KIF5B',
'LSM1',
'LSM4',
'MTHFD2',
'MTREX',
'NABP1',
'NFYA',
'NFYB',
'NHP2',
'NOLC1',
'NOP14',
'NOP56',
'NPM1',
'PAIP1',
'PARN',
'PDIA5',
'PDIA6',
'POP4',
'PREB',
'PSAT1',
'RPS14',
'RRP9',
'SDAD1',
'SEC11A',
'SEC31A',
'SERP1',
'SHC1',
'SKIC3',
'SLC1A4',
'SLC30A5',
'SLC7A5',
'SPCS1',
'SPCS3',
'SRPRA',
'SRPRB',
'SSR1',
'STC2',
'TARS1',
'TATDN2',
'TSPYL2',
'TUBB2A',
'VEGFA',
'WFS1',
'WIPI1',
'XBP1',
'XPOT',
'YIF1A',
'YWHAZ',
'ZBTB17'},
'HALLMARK_UV_RESPONSE_DN': {'ABCC1',
'ACVR2A',
'ADD3',
'ADGRL2',
'ADORA2B',
'AGGF1',
'AKT3',
'AMPH',
'ANXA2',
'ANXA4',
'APBB2',
'ARHGEF9',
'ATP2B1',
'ATP2B4',
'ATP2C1',
'ATRN',
'ATRX',
'ATXN1',
'BCKDHB',
'BDNF',
'BHLHE40',
'BMPR1A',
'CACNA1A',
'CAP2',
'CAV1',
'CCN1',
'CDC42BPA',
'CDK13',
'CDKN1B',
'CDON',
'CELF2',
'CITED2',
'COL11A1',
'COL1A1',
'COL1A2',
'COL3A1',
'COL5A2',
'DAB2',
'DBP',
'DDAH1',
'DLC1',
'DLG1',
'DMAC2L',
'DUSP1',
'DYRK1A',
'EFEMP1',
'ERBB2',
'F3',
'FBLN5',
'FHL2',
'FYN',
'FZD2',
'GCNT1',
'GJA1',
'GRK5',
'HAS2',
'ICA1',
'ID1',
'IGF1R',
'IGFBP5',
'INPP4B',
'INSIG1',
'IRS1',
'ITGB3',
'KALRN',
'KCNMA1',
'KIT',
'LAMC1',
'LDLR',
'LPAR1',
'LTBP1',
'MAGI2',
'MAP1B',
'MAP2K5',
'MAPK14',
'MET',
'MGLL',
'MGMT',
'MIOS',
'MMP16',
'MRPS31',
'MT1E',
'MTA1',
'MYC',
'NEK7',
'NFIB',
'NFKB1',
'NIPBL',
'NOTCH2',
'NR1D2',
'NR3C1',
'NRP1',
'PDGFRB',
'PDLIM5',
'PEX14',
'PHF3',
'PIAS3',
'PIK3CD',
'PIK3R3',
'PLCB4',
'PLPP3',
'PMP22',
'PPARG',
'PRDM2',
'PRKAR2B',
'PRKCA',
'PRKCE',
'PTEN',
'PTGFR',
'PTPN21',
'PTPRM',
'RASA2',
'RBPMS',
'RGS4',
'RND3',
'RUNX1',
'RXRA',
'SCAF8',
'SCHIP1',
'SCN8A',
'SDC2',
'SERPINE1',
'SFMBT1',
'SIPA1L1',
'SLC22A18',
'SLC7A1',
'SMAD3',
'SMAD7',
'SNAI2',
'SPOP',
'SRI',
'SYNE1',
'SYNJ2',
'TENT4A',
'TFPI',
'TGFBR2',
'TGFBR3',
'TJP1',
'TOGARAM1',
'VAV2',
'VLDLR',
'WDR37',
'YTHDC1',
'ZMIZ1'},
'HALLMARK_UV_RESPONSE_UP': {'ABCB1',
'ACAA1',
'AGO2',
'ALAS1',
'ALDOA',
'AMD1',
'AP2S1',
'APOM',
'AQP3',
'ARRB2',
'ASNS',
'ATF3',
'ATP6V1C1',
'ATP6V1F',
'BAK1',
'BCL2L11',
'BID',
'BMP2',
'BSG',
'BTG1',
'BTG2',
'BTG3',
'C4BPB',
'CA2',
'CASP3',
'CCK',
'CCND3',
'CCNE1',
'CDC34',
'CDC5L',
'CDK2',
'CDKN1C',
'CDKN2B',
'CDO1',
'CEBPG',
'CHKA',
'CHRNA5',
'CLCN2',
'CLTB',
'CNP',
'COL2A1',
'CREG1',
'CTSV',
'CXCL2',
'CYB5B',
'CYB5R1',
'CYP1A1',
'DDX21',
'DGAT1',
'DLG4',
'DNAJA1',
'DNAJB1',
'E2F5',
'EIF2S3',
'EIF5',
'ENO2',
'EPCAM',
'EPHX1',
'FEN1',
'FGF18',
'FKBP4',
'FMO1',
'FOS',
'FOSB',
'FURIN',
'GAL',
'GCH1',
'GGH',
'GLS',
'GPX3',
'GRINA',
'GRPEL1',
'H2AX',
'HLA-F',
'HMOX1',
'HNRNPU',
'HSPA13',
'HSPA2',
'HTR7',
'HYAL2',
'ICAM1',
'IGFBP2',
'IL6',
'IL6ST',
'IRF1',
'JUNB',
'KCNH2',
'KLHDC3',
'LHX2',
'LYN',
'MAOA',
'MAPK8IP2',
'MARK2',
'MGAT1',
'MMP14',
'MRPL23',
'MSX1',
'NAT1',
'NFKBIA',
'NKX2-5',
'NPTX2',
'NPTXR',
'NR4A1',
'NTRK3',
'NUP58',
'NXF1',
'OLFM1',
'ONECUT1',
'PARP2',
'PDAP1',
'PDLIM3',
'PLCL1',
'POLE3',
'POLG2',
'POLR2H',
'PPAT',
'PPIF',
'PPP1R2',
'PPT1',
'PRKACA',
'PRKCD',
'PRPF3',
'PSMC3',
'PTPRD',
'RAB27A',
'RASGRP1',
'RET',
'RFC4',
'RHOB',
'RPN1',
'RRAD',
'RXRB',
'SELENOW',
'SHOX2',
'SIGMAR1',
'SLC25A4',
'SLC6A12',
'SLC6A8',
'SOD2',
'SPR',
'SQSTM1',
'STARD3',
'STIP1',
'STK25',
'SULT1A1',
'TACR3',
'TAP1',
'TARS1',
'TCHH',
'TFRC',
'TGFBRAP1',
'TMBIM6',
'TST',
'TUBA4A',
'TYRO3',
'UROD',
'WIZ',
'YKT6'},
'HALLMARK_WNT_BETA_CATENIN_SIGNALING': {'ADAM17',
'AXIN1',
'AXIN2',
'CCND2',
'CSNK1E',
'CTNNB1',
'CUL1',
'DKK1',
'DKK4',
'DLL1',
'DVL2',
'FRAT1',
'FZD1',
'FZD8',
'GNAI1',
'HDAC11',
'HDAC2',
'HDAC5',
'HEY1',
'HEY2',
'JAG1',
'JAG2',
'KAT2A',
'LEF1',
'MAML1',
'MYC',
'NCOR2',
'NCSTN',
'NKD1',
'NOTCH1',
'NOTCH4',
'NUMB',
'PPARD',
'PSEN2',
'PTCH1',
'RBPJ',
'SKP2',
'TCF7',
'TP53',
'WNT1',
'WNT5B',
'WNT6'},
'HALLMARK_XENOBIOTIC_METABOLISM': {'ABCC2',
'ABCC3',
'ABCD2',
'ABHD6',
'ACO2',
'ACOX1',
'ACOX2',
'ACOX3',
'ACP1',
'ACP2',
'ACSM1',
'ADH1C',
'ADH5',
'ADH7',
'AHCY',
'AKR1C2',
'AKR1C3',
'ALAS1',
'ALDH2',
'ALDH3A1',
'ALDH9A1',
'ANGPTL3',
'AOX1',
'AP4B1',
'APOE',
'AQP9',
'ARG1',
'ARG2',
'ARPP19',
'ASL',
'ATOH8',
'ATP2A2',
'BCAR1',
'BCAT1',
'BLVRB',
'BPHL',
'CA2',
'CASP6',
'CAT',
'CBR1',
'CCL25',
'CD36',
'CDA',
'CDO1',
'CES1',
'CFB',
'CNDP2',
'COMT',
'CROT',
'CRP',
'CSAD',
'CYB5A',
'CYFIP2',
'CYP17A1',
'CYP1A1',
'CYP1A2',
'CYP26A1',
'CYP27A1',
'CYP2C18',
'CYP2E1',
'CYP2J2',
'CYP2S1',
'CYP4F2',
'DCXR',
'DDAH2',
'DDC',
'DDT',
'DHPS',
'DHRS1',
'DHRS7',
'ECH1',
'ELOVL5',
'ENPEP',
'ENTPD5',
'EPHA2',
'EPHX1',
'ESR1',
'ETFDH',
'ETS2',
'F10',
'F11',
'FABP1',
'FAH',
'FAS',
'FBLN1',
'FBP1',
'FETUB',
'FMO1',
'FMO3',
'G6PC1',
'GABARAPL1',
'GAD1',
'GART',
'GCH1',
'GCKR',
'GCLC',
'GCNT2',
'GNMT',
'GSR',
'GSS',
'GSTA3',
'GSTM4',
'GSTO1',
'GSTT2',
'HACL1',
'HES6',
'HGFAC',
'HMOX1',
'HNF4A',
'HPRT1',
'HRG',
'HSD11B1',
'HSD17B2',
'ID2',
'IDH1',
'IGF1',
'IGFBP1',
'IGFBP4',
'IL1R1',
'IRF8',
'ITIH1',
'ITIH4',
'JUP',
'KARS1',
'KYNU',
'LCAT',
'LEAP2',
'LONP1',
'LPIN2',
'MAN1A1',
'MAOA',
'MARCHF6',
'MBL2',
'MCCC2',
'MPP2',
'MT2A',
'MTHFD1',
'NDRG2',
'NFS1',
'NINJ1',
'NMT1',
'NPC1',
'NQO1',
'PAPSS2',
'PC',
'PDK4',
'PDLIM5',
'PEMT',
'PGD',
'PGRMC1',
'PINK1',
'PLG',
'PMM1',
'POR',
'PPARD',
'PROS1',
'PSMB10',
'PTGDS',
'PTGES',
'PTGES3',
'PTGR1',
'PTS',
'PYCR1',
'RAP1GAP',
'RBP4',
'REG1A',
'RETSAT',
'SAR1B',
'SERPINA6',
'SERPINE1',
'SERTAD1',
'SHMT2',
'SLC12A4',
'SLC1A5',
'SLC22A1',
'SLC35B1',
'SLC35D1',
'SLC46A3',
'SLC6A12',
'SLC6A6',
'SMOX',
'SPINT2',
'SSR3',
'TAT',
'TDO2',
'TGFB2',
'TKFC',
'TMBIM6',
'TMEM176B',
'TMEM97',
'TNFRSF1A',
'TPST1',
'TTPA',
'TYR',
'UGDH',
'UPB1',
'UPP1',
'VNN1',
'VTN',
'XDH'}}
The kegg results need to be reformatted into a dictionary for enrichment analysis:
In [17]:
Copied!
# Initialise an empty dictionary to store pathway name: gene names pairs
pathway_dict = {}
# Iterate through the pathway_gene_dict and populate the pathway_dict
for pathway_name, gene_list in kegg.items():
# Convert gene list to a set to remove duplicates
gene_set = set(gene_list)
# Assign gene set to pathway name in pathway_dict
pathway_dict[pathway_name] = gene_set
# Display the resulting dictionary
print(pathway_dict)
# Initialise an empty dictionary to store pathway name: gene names pairs
pathway_dict = {}
# Iterate through the pathway_gene_dict and populate the pathway_dict
for pathway_name, gene_list in kegg.items():
# Convert gene list to a set to remove duplicates
gene_set = set(gene_list)
# Assign gene set to pathway name in pathway_dict
pathway_dict[pathway_name] = gene_set
# Display the resulting dictionary
print(pathway_dict)
{'Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Homo sapiens hsa00532': {'B4GALT7', 'CHST13', 'CHST11', 'UST', 'XYLT1', 'CHST15', 'B3GALT6', 'B3GAT3', 'CHPF2', 'CHSY1', 'CHPF', 'CHST3', 'DSE', 'CHST12', 'CHST7', 'CSGALNACT1', 'CSGALNACT2', 'XYLT2', 'CHST14', 'CHSY3'}, 'Glycosaminoglycan biosynthesis - heparan sulfate / heparin Homo sapiens hsa00534': {'B4GALT7', 'NDST4', 'HS2ST1', 'EXTL1', 'EXTL3', 'XYLT1', 'B3GALT6', 'HS3ST3A1', 'B3GAT3', 'HS3ST5', 'EXT2', 'HS6ST1', 'HS3ST2', 'NDST2', 'EXT1', 'HS3ST1', 'HS3ST3B1', 'NDST1', 'XYLT2', 'EXTL2', 'NDST3', 'HS6ST3', 'HS6ST2', 'GLCE'}, 'Glycosylphosphatidylinositol(GPI)-anchor biosynthesis Homo sapiens hsa00563': {'PIGB', 'PIGN', 'PIGS', 'PGAP1', 'PIGO', 'PIGP', 'PIGT', 'PIGV', 'PIGQ', 'PIGF', 'GPLD1', 'PIGL', 'PIGH', 'GPAA1', 'PIGY', 'PIGG', 'PIGA', 'PIGC', 'PIGX', 'PIGW', 'PIGM', 'DPM2', 'PIGK', 'PIGU', 'PIGZ'}, 'Steroid biosynthesis Homo sapiens hsa00100': {'DHCR7', 'FDFT1', 'SQLE', 'SOAT1', 'NSDHL', 'TM7SF2', 'EBP', 'CYP2R1', 'CEL', 'SOAT2', 'FAXDC2', 'CYP27B1', 'CYP51A1', 'SC5D', 'HSD17B7', 'DHCR24', 'MSMO1', 'CYP24A1', 'LIPA', 'LSS'}, 'SNARE interactions in vesicular transport Homo sapiens hsa04130': {'SNAP29', 'VTI1A', 'STX17', 'SEC22B', 'STX19', 'STX16', 'VAMP4', 'VAMP1', 'SNAP23', 'STX11', 'VAMP7', 'STX1B', 'BNIP1', 'STX5', 'STX7', 'STX6', 'STX8', 'USE1', 'STX18', 'STX10', 'BET1L', 'YKT6', 'STX4', 'GOSR1', 'VAMP5', 'GOSR2', 'VAMP8', 'STX2', 'STX1A', 'STX3', 'VAMP3', 'VAMP2', 'BET1', 'VTI1B'}, 'Protein export Homo sapiens hsa03060': {'SEC61A1', 'SEC11C', 'SRP14', 'SPCS2', 'SEC61B', 'SRP19', 'SEC61A2', 'HSPA5', 'OXA1L', 'IMMP2L', 'SRPRB', 'SEC61G', 'SRP54', 'SPCS1', 'SRP72', 'SPCS3', 'SRPR', 'SEC63', 'SRP9', 'IMMP1L', 'SRP68', 'SEC62', 'SEC11A'}, 'Protein processing in endoplasmic reticulum Homo sapiens hsa04141': {'MAP3K5', 'ATXN3', 'SSR4', 'BAK1', 'EDEM1', 'PREB', 'CRYAB', 'RBX1', 'SEC61B', 'SEC31B', 'HSPA5', 'TRAM1', 'WFS1', 'TRAF2', 'SEC13', 'EIF2S1', 'DNAJC5G', 'SAR1A', 'UBQLNL', 'ATXN3L', 'VCP', 'HSPA2', 'UBE2G1', 'EDEM2', 'DERL1', 'DDIT3', 'CUL1', 'SSR2', 'CALR', 'HSP90AB1', 'RAD23B', 'SEC23B', 'SSR1', 'DNAJC1', 'EDEM3', 'DERL3', 'RNF185', 'BAG1', 'MAPK10', 'SEC31A', 'RPN1', 'HYOU1', 'SEC61A1', 'CAPN2', 'SEC24C', 'UBE2D3', 'P4HB', 'VIMP', 'PRKCSH', 'PARK2', 'ERO1LB', 'DERL2', 'UBE2E1', 'HSP90B1', 'SEL1L', 'MAN1A1', 'HSPBP1', 'MAN1C1', 'DAD1', 'UBE2E3', 'DDOST', 'BAG2', 'RPN2', 'CASP12', 'HSPA1A', 'HSPA1B', 'FBXO2', 'EIF2AK4', 'DNAJC3', 'MARCH6', 'UBE4B', 'DNAJC5', 'MBTPS2', 'UBE2D2', 'TXNDC5', 'FBXO6', 'MAP2K7', 'EIF2AK2', 'SAR1B', 'RNF5', 'DNAJB12', 'SEC63', 'NSFL1C', 'HSP90AA1', 'LMAN2', 'SYVN1', 'PLAA', 'DNAJC10', 'UBE2J1', 'ERLEC1', 'OS9', 'HSPA4L', 'TUSC3', 'GANAB', 'HSPA8', 'UBE2D1', 'HSPA6', 'BAX', 'ATF4', 'NFE2L2', 'ATF6', 'MAPK8', 'XBP1', 'CKAP4', 'SEC24D', 'CANX', 'SEC24A', 'DNAJB1', 'SEC24B', 'RAD23A', 'UGGT1', 'UBE2E2', 'UBE2J2', 'HSPH1', 'UBE2G2', 'DNAJB2', 'UBQLN4', 'ERO1L', 'MAPK9', 'ERN1', 'UBQLN3', 'PDIA3', 'SEC62', 'MAN1A2', 'LMAN1', 'AMFR', 'ERP29', 'PDIA4', 'STT3B', 'LMAN1L', 'SEL1L2', 'SKP1', 'UBE2D4', 'PDIA6', 'UGGT2', 'YOD1', 'LOC102724652', 'NPLOC4', 'SSR3', 'PPP1R15A', 'BCL2', 'DNAJA2', 'STT3A', 'SEC61A2', 'NGLY1', 'CAPN1', 'SEC61G', 'UBQLN1', 'UBQLN2', 'HSPA1L', 'UFD1L', 'DNAJC5B', 'HERPUD1', 'BCAP31', 'DNAJB11', 'EIF2AK3', 'EIF2AK1', 'MBTPS1', 'STUB1', 'MAN1B1', 'CRYAA', 'SEC23A', 'ATF6B', 'DNAJA1', 'SVIP', 'MOGS', 'UBXN6', 'RRBP1', 'SIL1'}, 'N-Glycan biosynthesis Homo sapiens hsa00510': {'MGAT4B', 'MGAT2', 'ALG2', 'STT3B', 'GANAB', 'ALG3', 'DPAGT1', 'ST6GAL1', 'FUT8', 'MGAT4D', 'ALG12', 'MGAT5B', 'MAN1A1', 'MGAT4A', 'STT3A', 'MAN1C1', 'ALG13', 'DAD1', 'ALG5', 'DDOST', 'RPN2', 'DPM3', 'ST6GAL2', 'B4GALT3', 'DPM1', 'B4GALT2', 'MAN2A1', 'MGAT3', 'ALG11', 'MAN1B1', 'DOLPP1', 'MGAT5', 'ALG10', 'MAN2A2', 'MGAT1', 'MGAT4C', 'DOLK', 'ALG8', 'DPM2', 'MAN1A2', 'ALG6', 'MOGS', 'ALG14', 'ALG9', 'ALG1', 'B4GALT1', 'ALG10B', 'TUSC3', 'RPN1'}, 'Other types of O-glycan biosynthesis Homo sapiens hsa00514': {'GXYLT1', 'ST6GAL1', 'COLGALT1', 'RFNG', 'B3GAT2', 'CHST10', 'MGAT5B', 'ST3GAL3', 'POFUT2', 'FUT4', 'MFNG', 'ST6GAL2', 'B4GALT3', 'FUT9', 'FUT7', 'COLGALT2', 'OGT', 'B4GALT2', 'POMT2', 'POGLUT1', 'EOGT', 'B3GAT1', 'POMT1', 'POMGNT1', 'LFNG', 'B3GALTL', 'POFUT1', 'GXYLT2', 'B3GALT4', 'B4GALT1', 'PLOD3'}, 'Glycosaminoglycan biosynthesis - keratan sulfate Homo sapiens hsa00533': {'B4GALT3', 'B3GNT7', 'CHST6', 'CHST4', 'ST3GAL3', 'B4GALT2', 'CHST1', 'B4GALT4', 'B3GNT1', 'ST3GAL1', 'CHST2', 'FUT8', 'B4GALT1', 'ST3GAL2', 'B3GNT2'}, 'Glycosphingolipid biosynthesis - lacto and neolacto series Homo sapiens hsa00601': {'ST3GAL6', 'B3GNT3', 'B3GNT5', 'B3GALT2', 'ST8SIA1', 'ST3GAL3', 'B4GALT4', 'B3GNT1', 'FUT4', 'FUT1', 'B4GALT3', 'FUT9', 'B3GALT5', 'FUT7', 'FUT5', 'B3GALT1', 'FUT6', 'B4GALT2', 'FUT3', 'FUT2', 'ABO', 'B3GNT4', 'ST3GAL4', 'GCNT2', 'B3GNT2', 'B4GALT1'}, 'Glycosphingolipid biosynthesis - globo series Homo sapiens hsa00603': {'FUT9', 'B3GALT5', 'ST8SIA1', 'HEXB', 'ST3GAL1', 'NAGA', 'GLA', 'HEXA', 'GBGT1', 'ST3GAL2', 'B3GALNT1', 'A4GALT', 'FUT2', 'FUT1'}, 'Glycosphingolipid biosynthesis - ganglio series Homo sapiens hsa00604': {'ST8SIA1', 'B4GALNT1', 'ST6GALNAC4', 'ST6GALNAC6', 'ST6GALNAC5', 'GLB1', 'HEXB', 'ST3GAL1', 'SLC33A1', 'B3GALT4', 'ST6GALNAC3', 'HEXA', 'ST3GAL2', 'ST8SIA5', 'ST3GAL5'}, 'Mucin type O-Glycan biosynthesis Homo sapiens hsa00512': {'GALNT18', 'GALNT14', 'GCNT4', 'ST3GAL1', 'GALNT5', 'GALNT12', 'C1GALT1C1', 'GALNT3', 'B4GALT5', 'WBSCR17', 'GALNTL5', 'GALNT4', 'GALNTL6', 'GALNT11', 'GCNT3', 'C1GALT1', 'GALNT10', 'POC1B-GALNT4', 'GALNT6', 'GALNT13', 'GALNT15', 'GALNT1', 'ST3GAL2', 'GALNT2', 'GALNT9', 'GALNT8', 'GALNT7', 'GCNT1', 'GALNT16', 'B3GNT6', 'ST6GALNAC1'}, 'Sphingolipid metabolism Homo sapiens hsa00600': {'SGMS1', 'SMPD1', 'PPAP2A', 'NEU3', 'NEU2', 'GLB1', 'ACER1', 'CERS5', 'ARSA', 'DEGS1', 'SGPL1', 'CERS1', 'B4GALT6', 'UGCG', 'GBA', 'ACER3', 'NEU4', 'CERS4', 'UGT8', 'SMPD2', 'CERS6', 'SMPD3', 'SPHK2', 'NEU1', 'CERS2', 'CERK', 'KDSR', 'DEGS2', 'ACER2', 'SPHK1', 'ASAH1', 'SGPP1', 'GBA2', 'SGPP2', 'SPTLC3', 'SMPD4', 'GLA', 'CERS3', 'PPAP2C', 'PPAP2B', 'SGMS2', 'SPTLC2', 'GAL3ST1', 'ENPP7', 'GALC', 'ASAH2', 'SPTLC1'}, 'Other glycan degradation Homo sapiens hsa00511': {'GBA', 'MAN2C1', 'HEXDC', 'GBA2', 'NEU3', 'NEU4', 'NEU2', 'MANBA', 'GLB1', 'AGA', 'MAN2B1', 'ENGASE', 'HEXB', 'MAN2B2', 'NEU1', 'HEXA', 'FUCA1', 'FUCA2'}, 'Glycosaminoglycan degradation Homo sapiens hsa00531': {'HYAL1', 'GLB1', 'HEXB', 'IDUA', 'HYAL3', 'ARSB', 'HPSE', 'SPAM1', 'NAGLU', 'IDS', 'HEXA', 'GALNS', 'GNS', 'SGSH', 'HYAL2', 'HPSE2', 'HYAL4', 'HGSNAT', 'GUSB'}, 'Lysosome Homo sapiens hsa04142': {'SMPD1', 'AP1G2', 'LAPTM4B', 'ARSA', 'CTSW', 'GBA', 'CTSC', 'LAPTM4A', 'CTSE', 'AP1S1', 'AP3D1', 'MAN2B1', 'MFSD8', 'AP3M1', 'CTSH', 'CLTB', 'ASAH1', 'AP3S2', 'AGA', 'AP3S1', 'GLA', 'SORT1', 'ATP6V0C', 'GALNS', 'GNS', 'LITAF', 'SGSH', 'PLA2G15', 'HGSNAT', 'FUCA1', 'CD63', 'GNPTG', 'NPC1', 'GLB1', 'IDUA', 'M6PR', 'CD164', 'GGA1', 'SLC11A1', 'AP4B1', 'AP1S3', 'NAGLU', 'GAA', 'CTSL', 'IDS', 'ATP6V0A2', 'SLC17A5', 'LAMP1', 'PSAPL1', 'ARSG', 'CTSA', 'GNPTAB', 'HEXA', 'CLTCL1', 'PPT2', 'GM2A', 'CTSD', 'TPP1', 'GGA2', 'CTSK', 'ACP5', 'CTSZ', 'NAGA', 'AP1M2', 'GUSB', 'ABCB9', 'MANBA', 'AP4S1', 'GGA3', 'HEXB', 'NAPSA', 'CLTA', 'AP4M1', 'PPT1', 'ATP6V0A4', 'ATP6V0A1', 'PSAP', 'NEU1', 'SUMF1', 'AP3B1', 'LAPTM5', 'CTSF', 'ATP6AP1', 'CTSG', 'ATP6V1H', 'CLTC', 'LAMP2', 'ATP6V0B', 'NAGPA', 'CLN5', 'ATP6V0D2', 'ABCA2', 'SCARB2', 'AP1S2', 'LAMP3', 'CD68', 'HYAL1', 'CLN3', 'NPC2', 'ENTPD4', 'CTSV', 'ARSB', 'CTSB', 'AP1B1', 'CTSS', 'AP1M1', 'SLC11A2', 'DNASE2', 'ACP2', 'LGMN', 'CTNS', 'AP3B2', 'AP3M2', 'TCIRG1', 'CTSO', 'DNASE2B', 'AP1G1', 'AP4E1', 'IGF2R', 'GALC', 'MCOLN1', 'LIPA', 'ATP6V0D1'}, 'Synaptic vesicle cycle Homo sapiens hsa04721': {'SLC18A2', 'STXBP1', 'AP2B1', 'CACNA1A', 'SLC17A7', 'ATP6V1E1', 'SYT1', 'CACNA1B', 'ATP6V1F', 'CLTA', 'NSF', 'SLC32A1', 'ATP6V1D', 'DNM2', 'ATP6V1A', 'ATP6V1E2', 'STX1B', 'ATP6V0A4', 'ATP6V0A1', 'ATP6V0A2', 'ATP6V1G3', 'SLC18A3', 'ATP6V1C2', 'DNM1', 'SLC18A1', 'ATP6V1G1', 'CLTCL1', 'CLTB', 'RAB3A', 'UNC13C', 'AP2S1', 'SNAP25', 'ATP6V1B1', 'CPLX4', 'ATP6V0E2', 'ATP6V1H', 'TCIRG1', 'AP2M1', 'STX2', 'DNM3', 'ATP6V0C', 'SLC17A6', 'CLTC', 'ATP6V0B', 'STX1A', 'STX3', 'RIMS1', 'ATP6V1G2', 'AP2A2', 'CPLX3', 'VAMP2', 'ATP6V0D2', 'UNC13A', 'ATP6V0E1', 'CPLX1', 'AP2A1', 'SLC17A8', 'ATP6V0D1', 'ATP6V1B2', 'NAPA', 'CPLX2', 'ATP6V1C1', 'UNC13B'}, 'Collecting duct acid secretion Homo sapiens hsa04966': {'CA2', 'ATP6V1E1', 'ATP6V1F', 'ATP4B', 'ATP6V1D', 'SLC4A1', 'ATP6V1A', 'ATP6V1E2', 'ATP6V0A4', 'ATP6V0A1', 'ATP4A', 'ATP6V0A2', 'ATP6V1G3', 'ATP6V1C2', 'ATP6V1G1', 'ATP6V1B1', 'ATP6V0E2', 'TCIRG1', 'ATP6V0C', 'SLC12A7', 'CLCNKB', 'ATP6V1G2', 'ATP6V0D2', 'ATP6V0E1', 'ATP6V0D1', 'ATP6V1B2', 'ATP6V1C1'}, 'Vibrio cholerae infection Homo sapiens hsa05110': {'PDIA4', 'MUC2', 'CFTR', 'ADCY9', 'ADCY3', 'SEC61A1', 'SLC12A2', 'ATP6V1E1', 'ATP6V1F', 'SEC61B', 'ATP6V1D', 'PLCG2', 'ATP6V1A', 'ATP6V1E2', 'SEC61A2', 'ATP6V0A4', 'ATP6V0A1', 'ATP6V0A2', 'SEC61G', 'PRKACA', 'ATP6V1G3', 'ATP6V1C2', 'ATP6V1G1', 'KDELR2', 'KDELR1', 'PRKACG', 'PRKCA', 'KCNQ1', 'KDELR3', 'PLCG1', 'ATP6V1B1', 'ACTG1', 'ATP6AP1', 'ATP6V0E2', 'ATP6V1H', 'TCIRG1', 'ATP6V0C', 'ATP6V0B', 'ERO1L', 'ATP6V1G2', 'TJP1', 'ATP6V0D2', 'ATP6V0E1', 'ARF1', 'GNAS', 'TJP2', 'PRKACB', 'ATP6V0D1', 'ATP6V1B2', 'ACTB', 'ATP6V1C1'}, 'Epithelial cell signaling in Helicobacter pylori infection Homo sapiens hsa05120': {'CXCR2', 'IGSF5', 'F11R', 'CCL5', 'CDC42', 'ATP6V1E1', 'PTPN11', 'NOD1', 'MAP2K4', 'CHUK', 'CXCR1', 'ATP6V1F', 'MET', 'ATP6V1D', 'PLCG2', 'ATP6V1A', 'EGFR', 'ATP6V1E2', 'GIT1', 'MAPK13', 'ATP6V0A4', 'ATP6V0A1', 'PTPRZ1', 'ADAM17', 'NFKB1', 'ATP6V0A2', 'ATP6V1G3', 'ATP6V1C2', 'MAPK14', 'MAP3K14', 'ATP6V1G1', 'MAPK8', 'RELA', 'JAM3', 'CASP3', 'MAPK12', 'PLCG1', 'ATP6V1B1', 'MAPK11', 'NFKBIA', 'CXCL8', 'ATP6AP1', 'CXCL1', 'ATP6V0E2', 'SRC', 'PAK1', 'ADAM10', 'ATP6V1B2', 'TCIRG1', 'JAM2', 'IKBKB', 'ATP6V0C', 'ATP6V1H', 'JUN', 'IKBKG', 'ATP6V0B', 'MAPK9', 'ATP6V1G2', 'HBEGF', 'TJP1', 'ATP6V0D2', 'ATP6V0E1', 'CSK', 'ATP6V0D1', 'LYN', 'RAC1', 'ATP6V1C1', 'MAPK10'}, 'Rheumatoid arthritis Homo sapiens hsa05323': {'TLR4', 'IFNG', 'HLA-DRB3', 'ATP6V1F', 'HLA-DPA1', 'ANGPT1', 'IL15', 'ATP6V1G3', 'ATP6V1C2', 'ATP6V1G1', 'CSF1', 'CXCL8', 'CXCL12', 'VEGFA', 'TNF', 'ATP6V0C', 'CD86', 'ATP6V1G2', 'HLA-DRB4', 'HLA-DRA', 'ATP6V1B2', 'HLA-DMA', 'CCL5', 'LTB', 'ATP6V1A', 'ATP6V1E2', 'CTSL', 'ATP6V0A2', 'TGFB2', 'IL17A', 'CCL3L3', 'TGFB1', 'HLA-DPB1', 'HLA-DOB', 'CXCL1', 'CTSK', 'ACP5', 'IL1A', 'ATP6V0E1', 'ATP6V1C1', 'IL1B', 'IL11', 'TNFSF11', 'HLA-DRB1', 'CD80', 'ATP6V1E1', 'ICAM1', 'CXCL6', 'TNFRSF11A', 'ATP6V0A4', 'ATP6V0A1', 'HLA-DQA2', 'HLA-DMB', 'ATP6V1B1', 'ATP6AP1', 'HLA-DRB5', 'CCL20', 'ATP6V1H', 'JUN', 'CD28', 'CCL3L1', 'ATP6V0B', 'HLA-DOA', 'ATP6V0D2', 'MMP3', 'HLA-DQB1', 'LOC102723407', 'IL18', 'FOS', 'ATP6V1D', 'CCL3', 'TEK', 'TNFSF13B', 'ITGAL', 'IL23A', 'IL6', 'ATP6V0E2', 'MMP1', 'TNFSF13', 'CXCL5', 'TLR2', 'TCIRG1', 'TGFB3', 'CSF2', 'CCL2', 'ITGB2', 'CTLA4', 'ATP6V0D1', 'FLT1', 'HLA-DQA1'}, 'Phagosome Homo sapiens hsa04145': {'TLR4', 'HLA-DRB3', 'ATP6V1F', 'SEC61B', 'TUBB3', 'FCGR3A', 'FCGR2C', 'TAP1', 'THBS3', 'ATP6V1G3', 'ATP6V1C2', 'CLEC7A', 'ATP6V1G1', 'FCGR2A', 'SFTPA2', 'ITGA2', 'TUBA8', 'CALR', 'ATP6V0C', 'NOX1', 'CD36', 'VAMP3', 'ATP6V1G2', 'HLA-C', 'RILP', 'HLA-DRB4', 'ITGAV', 'PIKFYVE', 'HLA-DRA', 'ATP6V1B2', 'RAC1', 'HLA-DMA', 'MARCO', 'C1R', 'ITGB5', 'DYNC1LI1', 'RAB5A', 'SEC61A1', 'CLEC4M', 'TUBB2B', 'DYNC1I1', 'TUBB2A', 'THBS1', 'M6PR', 'SFTPD', 'SEC22B', 'TUBB8', 'ATP6V1A', 'ATP6V1E2', 'STX12', 'HLA-B', 'TAP2', 'CTSL', 'ATP6V0A2', 'LAMP1', 'DYNC1LI2', 'THBS4', 'THBS2', 'TUBAL3', 'CYBB', 'NCF4', 'HLA-F', 'HLA-DPB1', 'TUBA1C', 'ITGB3', 'CYBA', 'PLA2R1', 'HLA-DOB', 'TUBB1', 'CD209', 'TUBB4B', 'ITGA5', 'EEA1', 'ATP6V0E1', 'TFRC', 'NCF1', 'TUBA4A', 'HLA-G', 'ATP6V1C1', 'TUBB6', 'PIK3C3', 'FCGR1A', 'NOX3', 'FCGR2B', 'HLA-DRB1', 'MRC2', 'RAB5C', 'TUBB', 'ATP6V1E1', 'TUBA3E', 'COMP', 'MPO', 'ATP6V0A4', 'ATP6V0A1', 'HLA-DQA2', 'NOS1', 'HLA-DMB', 'ITGB1', 'CANX', 'HLA-E', 'ATP6V1B1', 'ATP6AP1', 'STX18', 'HLA-DRB5', 'MRC1', 'C3', 'COLEC12', 'TUBA3C', 'ATP6V1H', 'FCAR', 'HLA-A', 'CD14', 'OLR1', 'LAMP2', 'ATP6V0B', 'HLA-DOA', 'ATP6V0D2', 'TUBA1B', 'SFTPA1', 'TUBA3D', 'ACTB', 'MSR1', 'NCF2', 'HLA-DQB1', 'FCGR3B', 'LOC102723407', 'TUBB4A', 'ATP6V1D', 'DYNC1H1', 'SCARB1', 'SEC61A2', 'SEC61G', 'HGS', 'RAB7B', 'TLR6', 'STX7', 'DYNC2H1', 'CTSS', 'RAB5B', 'DYNC1I2', 'ACTG1', 'ATP6V0E2', 'ITGAM', 'TUBA1A', 'TCIRG1', 'TLR2', 'COLEC11', 'RAB7A', 'MBL2', 'ITGB2', 'CORO1A', 'ATP6V0D1', 'HLA-DPA1', 'HLA-DQA1'}, 'Tuberculosis Homo sapiens hsa05152': {'TIRAP', 'TLR4', 'IFNG', 'CAMK2D', 'HLA-DRB3', 'CD74', 'IFNA7', 'RAF1', 'AKT3', 'FCGR3A', 'HLA-DPA1', 'CAMK2G', 'FCGR2C', 'PPP3CB', 'NOD2', 'CLEC7A', 'IFNA5', 'MAPK14', 'PLK3', 'CASP10', 'RELA', 'FCGR2A', 'IFNGR2', 'CALM1', 'PPP3R2', 'MAPK11', 'IFNA21', 'CR1', 'TNF', 'ATP6V0C', 'CAMP', 'HLA-DRB4', 'HLA-DRA', 'HLA-DMA', 'CALML6', 'MAPK10', 'RAB5A', 'IL12A', 'CASP8', 'IFNA6', 'CLEC4M', 'RHOA', 'AKT2', 'LSP1', 'IRAK2', 'IRAK1', 'IFNA1', 'IFNA13', 'IFNA8', 'ATP6V0A2', 'TGFB2', 'LAMP1', 'PPP3CC', 'SPHK2', 'FCER1G', 'IFNA2', 'TGFB1', 'IFNA10', 'HLA-DPB1', 'IL10RB', 'CAMK2B', 'RFXAP', 'IFNGR1', 'PLA2R1', 'CYP27B1', 'HLA-DOB', 'CALML3', 'IFNB1', 'CTSD', 'CASP9', 'CEBPB', 'CD209', 'APAF1', 'EEA1', 'FADD', 'HSPA9', 'TLR9', 'NFYC', 'IL1A', 'IFNA16', 'CALM2', 'NOS2', 'IL1B', 'RFX5', 'PIK3C3', 'FCGR1A', 'FCGR2B', 'LBP', 'MYD88', 'HLA-DRB1', 'TLR1', 'MRC2', 'RAB5C', 'ITGAX', 'MAPK1', 'RFXANK', 'BID', 'CLEC4E', 'MAPK13', 'ATP6V0A4', 'BAX', 'ATP6V0A1', 'HLA-DQA2', 'NFKB1', 'CARD9', 'MAPK8', 'CYCS', 'HLA-DMB', 'ATP6AP1', 'HLA-DRB5', 'MRC1', 'IFNA4', 'EP300', 'C3', 'SRC', 'ATP6V1H', 'MAPK3', 'CALM3', 'CAMK2A', 'MALT1', 'CD14', 'VDR', 'LAMP2', 'ATP6V0B', 'PPP3R1', 'HLA-DOA', 'MAPK9', 'ATP6V0D2', 'PPP3CA', 'IRAK4', 'STAT1', 'IL10', 'CREB1', 'HLA-DQB1', 'FCGR3B', 'LOC102723407', 'KSR1', 'IL12B', 'IL18', 'BAD', 'HSPD1', 'BCL10', 'TRAF6', 'TRADD', 'CEBPG', 'AKT1', 'BCL2', 'SYK', 'IL10RA', 'TLR6', 'CIITA', 'CTSS', 'NFYA', 'RAB5B', 'CASP3', 'MAPK12', 'SPHK1', 'IL23A', 'JAK2', 'IL6', 'ITGAM', 'NFYB', 'IFNA14', 'RIPK2', 'TCIRG1', 'TLR2', 'CREBBP', 'TGFB3', 'RAB7A', 'IFNA17', 'ITGB2', 'CORO1A', 'ATP6V0D1', 'TNFRSF1A', 'HLA-DQA1', 'JAK1', 'CALML5', 'ARHGEF12'}, 'Toxoplasmosis Homo sapiens hsa05145': {'LAMC3', 'TLR4', 'IFNG', 'HLA-DRB3', 'CHUK', 'PIK3R1', 'AKT3', 'TYK2', 'HLA-DPA1', 'ALOX5', 'MAPK14', 'RELA', 'LAMB2', 'IFNGR2', 'GNAI1', 'LAMA1', 'MAPK11', 'STAT3', 'HSPA2', 'TNF', 'GNAO1', 'PIK3CD', 'HLA-DRB4', 'MAP2K6', 'HLA-DRA', 'TAB1', 'LAMC2', 'LAMA4', 'HLA-DMA', 'MAPK10', 'IL12A', 'CASP8', 'NFKBIB', 'AKT2', 'LAMA3', 'IRAK1', 'TGFB2', 'TGFB1', 'HSPA1A', 'HSPA1B', 'HLA-DPB1', 'IL10RB', 'IFNGR1', 'HLA-DOB', 'TAB2', 'BIRC7', 'CASP9', 'PIK3CB', 'IKBKB', 'PDPK1', 'MAP3K7', 'LAMB4', 'BCL2L1', 'SOCS1', 'LAMA5', 'NOS2', 'BIRC2', 'MYD88', 'HLA-DRB1', 'BIRC3', 'MAPK1', 'HSPA8', 'PIK3CA', 'GNAI2', 'HSPA6', 'MAPK13', 'HLA-DQA2', 'NFKB1', 'MAPK8', 'MAP2K3', 'PIK3R2', 'CYCS', 'LAMB1', 'HLA-DMB', 'ITGB1', 'NFKBIA', 'HLA-DRB5', 'ITGA6', 'LAMA2', 'MAPK3', 'LDLR', 'HLA-DOA', 'MAPK9', 'LAMB3', 'IRAK4', 'STAT1', 'IL10', 'JAK1', 'PIK3CG', 'HLA-DQB1', 'IL12B', 'BAD', 'XIAP', 'PPIF', 'PIK3R5', 'TRAF6', 'AKT1', 'BCL2', 'BIRC8', 'IL10RA', 'CIITA', 'LY96', 'HSPA1L', 'CASP3', 'MAPK12', 'LAMC1', 'JAK2', 'TLR2', 'TGFB3', 'IRGM', 'IKBKG', 'CD40LG', 'GNAI3', 'CD40', 'PIK3R3', 'TNFRSF1A', 'HLA-DQA1', 'CCR5'}, 'Leishmaniasis Homo sapiens hsa05140': {'IL1B', 'NCF2', 'FCGR1A', 'IL12A', 'TLR4', 'HLA-DQB1', 'ELK1', 'IFNG', 'FCGR3B', 'LOC102723407', 'MYD88', 'HLA-DRB1', 'MAPK1', 'IL12B', 'NFKBIB', 'FOS', 'HLA-DRB3', 'IL4', 'FCGR3A', 'TRAF6', 'HLA-DPA1', 'IRAK1', 'MAPK13', 'FCGR2C', 'HLA-DQA2', 'TGFB2', 'NFKB1', 'MAPK14', 'NCF4', 'TGFB1', 'RELA', 'ITGA4', 'FCGR2A', 'PTPN6', 'IFNGR2', 'HLA-DPB1', 'MAPK12', 'ITGB1', 'IFNGR1', 'CYBA', 'HLA-DMB', 'NOS2', 'MAPK11', 'NFKBIA', 'HLA-DOB', 'HLA-DRB5', 'JAK2', 'TAB2', 'ITGAM', 'C3', 'PTGS2', 'CR1', 'TNF', 'TLR2', 'MAPK3', 'TGFB3', 'MAP3K7', 'JUN', 'HLA-DOA', 'ITGB2', 'HLA-DMA', 'HLA-DRB4', 'IL1A', 'HLA-DRA', 'IRAK4', 'NCF1', 'IL10', 'HLA-DQA1', 'STAT1', 'TAB1', 'PRKCB', 'JAK1', 'MARCKSL1'}, 'Inflammatory bowel disease (IBD) Homo sapiens hsa05321': {'IL1B', 'IL12A', 'TLR4', 'HLA-DQB1', 'IFNG', 'HLA-DRB1', 'IL13', 'IL23R', 'IL12B', 'IL18', 'RORA', 'HLA-DRB3', 'IL4', 'TBX21', 'HLA-DQA1', 'IL12RB2', 'MAF', 'IL21R', 'IL18R1', 'HLA-DPA1', 'HLA-DQA2', 'TGFB2', 'NOD2', 'NFATC1', 'NFKB1', 'IL17A', 'SMAD3', 'IL17F', 'TGFB1', 'RELA', 'IL22', 'IFNGR2', 'HLA-DPB1', 'HLA-DMB', 'IL2RG', 'IL2', 'IFNGR1', 'SMAD2', 'STAT3', 'IL18RAP', 'IL23A', 'HLA-DOB', 'IL6', 'HLA-DRB5', 'STAT6', 'TNF', 'TLR2', 'TGFB3', 'FOXP3', 'GATA3', 'JUN', 'IL5', 'HLA-DOA', 'RORC', 'HLA-DMA', 'HLA-DRB4', 'IL1A', 'STAT4', 'IL21', 'HLA-DRA', 'STAT1', 'IL10', 'IL4R', 'TLR5', 'IL12RB1'}, 'Asthma Homo sapiens hsa05310': {'HLA-DQB1', 'HLA-DRB1', 'IL13', 'LOC102723407', 'HLA-DRB3', 'IL4', 'MS4A2', 'HLA-DQA1', 'HLA-DPA1', 'HLA-DQA2', 'FCER1G', 'IL9', 'HLA-DPB1', 'HLA-DMB', 'HLA-DRB5', 'HLA-DOB', 'RNASE3', 'PRG2', 'TNF', 'CCL11', 'IL5', 'CD40LG', 'EPX', 'HLA-DOA', 'FCER1A', 'CD40', 'HLA-DRB4', 'IL3', 'HLA-DRA', 'IL10', 'HLA-DMA'}, 'Intestinal immune network for IgA production Homo sapiens hsa04672': {'HLA-DQB1', 'TNFRSF17', 'ITGB7', 'HLA-DRB1', 'LOC102723407', 'CD80', 'CCL25', 'TNFRSF13C', 'HLA-DRB3', 'PIGR', 'IL4', 'IL15RA', 'HLA-DQA1', 'CCR9', 'ICOSLG', 'HLA-DPA1', 'IL15', 'CCR10', 'HLA-DQA2', 'MAP3K14', 'TGFB1', 'TNFSF13B', 'ITGA4', 'HLA-DPB1', 'HLA-DMB', 'CXCR4', 'MADCAM1', 'AICDA', 'IL2', 'CCL28', 'HLA-DRB5', 'HLA-DOB', 'IL6', 'TNFSF13', 'CXCL12', 'ICOS', 'CD86', 'CD28', 'IL5', 'CD40LG', 'LTBR', 'HLA-DOA', 'CD40', 'HLA-DRB4', 'TNFRSF13B', 'HLA-DRA', 'IL10', 'HLA-DMA'}, 'Viral myocarditis Homo sapiens hsa05416': {'CASP8', 'HLA-DQB1', 'CXADR', 'HLA-DRB1', 'LOC102723407', 'CD80', 'MYH7', 'RAC3', 'HLA-DRB3', 'RAC2', 'CAV1', 'ICAM1', 'BID', 'ABL2', 'SGCG', 'HLA-B', 'SGCD', 'HLA-DQA2', 'RAC1', 'EIF4G2', 'DMD', 'ABL1', 'CD55', 'CYCS', 'HLA-F', 'HLA-DPB1', 'PRF1', 'HLA-DMB', 'CASP3', 'CCND1', 'MYH6', 'DAG1', 'HLA-E', 'ACTG1', 'ITGAL', 'HLA-DOB', 'HLA-DRB5', 'EIF4G3', 'CASP9', 'LAMA2', 'SGCA', 'FYN', 'HLA-A', 'CD86', 'CD28', 'CD40LG', 'HLA-DOA', 'HLA-C', 'ITGB2', 'CD40', 'HLA-DMA', 'HLA-DRB4', 'EIF4G1', 'HLA-DRA', 'HLA-DPA1', 'HLA-DQA1', 'SGCB', 'HLA-G', 'ACTB'}, 'Autoimmune thyroid disease Homo sapiens hsa05320': {'HLA-DQB1', 'TG', 'IFNA6', 'HLA-DRB1', 'LOC102723407', 'TPO', 'CD80', 'HLA-DRB3', 'IL4', 'GZMB', 'IFNA7', 'HLA-DPA1', 'IFNA1', 'CGA', 'IFNA13', 'HLA-B', 'IFNA8', 'HLA-DQA2', 'IFNA5', 'IFNA2', 'IFNA10', 'HLA-F', 'HLA-DPB1', 'PRF1', 'HLA-DMB', 'IL2', 'HLA-E', 'IFNA21', 'HLA-DOB', 'HLA-DRB5', 'IFNA4', 'IFNA14', 'TSHR', 'HLA-A', 'FASLG', 'CD86', 'CD28', 'FAS', 'IL5', 'HLA-DOA', 'IFNA17', 'CD40LG', 'HLA-C', 'CD40', 'HLA-DMA', 'HLA-DRB4', 'HLA-DRA', 'CTLA4', 'TSHB', 'IL10', 'HLA-DQA1', 'IFNA16', 'HLA-G'}, 'Allograft rejection Homo sapiens hsa05330': {'IL12A', 'HLA-DQB1', 'IFNG', 'HLA-DRB1', 'LOC102723407', 'IL12B', 'CD80', 'HLA-DRB3', 'IL4', 'GZMB', 'HLA-DQA1', 'HLA-DPA1', 'HLA-B', 'HLA-DQA2', 'HLA-F', 'HLA-DPB1', 'PRF1', 'HLA-DMB', 'IL2', 'HLA-E', 'HLA-DRB5', 'HLA-DOB', 'TNF', 'HLA-A', 'FASLG', 'CD86', 'CD28', 'FAS', 'IL5', 'CD40LG', 'HLA-DOA', 'HLA-C', 'CD40', 'HLA-DRB4', 'HLA-DRA', 'IL10', 'HLA-DMA', 'HLA-G'}, 'Type I diabetes mellitus Homo sapiens hsa04940': {'IL1B', 'IL12A', 'HLA-DQB1', 'IFNG', 'HLA-DRB1', 'IL12B', 'CD80', 'HLA-DRB3', 'GZMB', 'HSPD1', 'HLA-DQA1', 'PTPRN2', 'HLA-B', 'HLA-DQA2', 'LTA', 'HLA-F', 'HLA-DPB1', 'PRF1', 'HLA-DMB', 'IL2', 'CPE', 'HLA-E', 'HLA-DRB5', 'HLA-DOB', 'GAD2', 'INS', 'TNF', 'PTPRN', 'HLA-A', 'FASLG', 'CD86', 'CD28', 'FAS', 'HLA-DOA', 'HLA-C', 'HLA-DRB4', 'ICA1', 'IL1A', 'HLA-DRA', 'HLA-DPA1', 'HLA-DMA', 'HLA-G', 'GAD1'}, 'Graft-versus-host disease Homo sapiens hsa05332': {'IL1B', 'HLA-DQB1', 'IFNG', 'HLA-DRB1', 'CD80', 'HLA-DRB3', 'KIR3DL1', 'GZMB', 'HLA-DQA1', 'KLRC1', 'HLA-B', 'HLA-DQA2', 'KIR3DL2', 'KIR2DL5A', 'HLA-F', 'HLA-DPB1', 'PRF1', 'HLA-DMB', 'IL2', 'HLA-E', 'KIR2DL1', 'HLA-DRB5', 'HLA-DOB', 'IL6', 'KIR2DL3', 'TNF', 'HLA-A', 'FASLG', 'CD86', 'CD28', 'FAS', 'HLA-DOA', 'HLA-C', 'KIR2DL2', 'KLRD1', 'HLA-DRB4', 'IL1A', 'HLA-DRA', 'HLA-DPA1', 'HLA-DMA', 'HLA-G'}, 'Antigen processing and presentation Homo sapiens hsa04612': {'IFNG', 'TAPBP', 'HLA-DRB3', 'CD74', 'KLRC1', 'HSPA5', 'TAP1', 'KIR3DL2', 'HSPA2', 'TNF', 'CD8B', 'CALR', 'HSP90AB1', 'KLRC4', 'HLA-C', 'KIR2DL2', 'KLRD1', 'HLA-DRB4', 'HLA-DRA', 'KIR2DL5A', 'HLA-DMA', 'HLA-B', 'TAP2', 'CTSL', 'HSPA1A', 'HLA-F', 'HSPA1B', 'HLA-DPB1', 'RFXAP', 'HLA-DOB', 'KIR3DL3', 'KIR2DS3', 'HSP90AA1', 'NFYC', 'HLA-G', 'RFX5', 'CD4', 'PSME1', 'HLA-DRB1', 'KLRC3', 'KIR3DL1', 'RFXANK', 'HSPA8', 'KIR2DS4', 'HSPA6', 'B2M', 'HLA-DQA2', 'HLA-DMB', 'CANX', 'HLA-E', 'HLA-DRB5', 'PSME3', 'HLA-A', 'HLA-DOA', 'PDIA3', 'KIR2DL4', 'CREB1', 'HLA-DQB1', 'KLRC2', 'KIR2DS2', 'CTSB', 'CIITA', 'CTSS', 'NFYA', 'KIR2DS1', 'HSPA1L', 'PSME2', 'KIR2DL1', 'LGMN', 'KIR2DL3', 'NFYB', 'KIR2DS5', 'HSPA4', 'CD8A', 'IFI30', 'HLA-DPA1', 'HLA-DQA1'}, 'Cell adhesion molecules (CAMs) Homo sapiens hsa04514': {'F11R', 'CLDN7', 'HLA-DRB3', 'SDC2', 'CLDN14', 'NEO1', 'CLDN4', 'HLA-DPA1', 'CLDN6', 'CLDN9', 'CNTN2', 'CD2', 'ITGB8', 'ITGA8', 'ITGA9', 'CDH3', 'MADCAM1', 'NFASC', 'CD58', 'CD226', 'PDCD1LG2', 'CDH1', 'SELL', 'CD274', 'CLDN20', 'ICOS', 'CD8B', 'CD86', 'CD276', 'PECAM1', 'SIGLEC1', 'HLA-C', 'CLDN15', 'HLA-DRB4', 'ITGAV', 'HLA-DRA', 'HLA-DMA', 'NLGN1', 'ALCAM', 'CLDN3', 'SELP', 'ICAM2', 'CD34', 'ESAM', 'VTCN1', 'HLA-B', 'NTNG2', 'CDH4', 'HLA-F', 'ITGA4', 'NLGN3', 'HLA-DPB1', 'HLA-DOB', 'CDH15', 'MPZ', 'MPZL1', 'LRRC4C', 'CADM3', 'CLDN25', 'CLDN17', 'SELPLG', 'TIGIT', 'HLA-G', 'NCAM1', 'SDC3', 'CD4', 'NRXN2', 'ITGB7', 'HLA-DRB1', 'CD80', 'MAG', 'LRRC4', 'CD22', 'ICAM1', 'ICOSLG', 'NTNG1', 'CD6', 'SELE', 'PVR', 'HLA-DQA2', 'HLA-DMB', 'ITGB1', 'HLA-E', 'CNTNAP2', 'HLA-DRB5', 'PVRL1', 'ITGA6', 'NLGN2', 'NRCAM', 'HLA-A', 'PTPRF', 'SDC4', 'CD28', 'HLA-DOA', 'SPN', 'CLDN8', 'SDC1', 'CLDN5', 'PDCD1', 'HLA-DQB1', 'CLDN23', 'PVRL3', 'CD99', 'PTPRC', 'CDH2', 'CLDN22', 'CDH5', 'CLDN10', 'NCAM2', 'CLDN16', 'CLDN19', 'CNTNAP1', 'NEGR1', 'PTPRM', 'ICAM3', 'JAM3', 'L1CAM', 'NRXN1', 'GLG1', 'ITGAL', 'ITGAM', 'CNTN1', 'CLDN2', 'JAM2', 'CLDN11', 'NLGN4X', 'OCLN', 'CD8A', 'NRXN3', 'CADM1', 'CD40LG', 'CLDN24', 'LRRC4B', 'CD40', 'ITGB2', 'VCAN', 'CTLA4', 'PVRL2', 'CLDN1', 'HLA-DQA1', 'CLDN18', 'VCAM1'}, 'Staphylococcus aureus infection Homo sapiens hsa05150': {'MASP2', 'FCGR1A', 'FCGR2B', 'HLA-DQB1', 'FCGR3B', 'SELP', 'LOC102723407', 'HLA-DRB1', 'HLA-DRB3', 'ICAM1', 'C5', 'PTAFR', 'C2', 'CFB', 'FCGR3A', 'C1QC', 'HLA-DPA1', 'FCGR2C', 'HLA-DQA2', 'C1S', 'CFD', 'DSG1', 'C3AR1', 'FCGR2A', 'HLA-DPB1', 'HLA-DMB', 'MASP1', 'C5AR1', 'HLA-DOB', 'HLA-DRB5', 'ITGAL', 'ITGAM', 'C3', 'PLG', 'FGG', 'FCAR', 'C4A', 'C1QB', 'FPR3', 'MBL2', 'KRT10', 'CFH', 'HLA-DOA', 'C4B', 'FPR1', 'ITGB2', 'HLA-DMA', 'HLA-DRB4', 'HLA-DRA', 'CFI', 'IL10', 'HLA-DQA1', 'SELPLG', 'FPR2', 'C1QA', 'C1R'}, 'Complement and coagulation cascades Homo sapiens hsa04610': {'MASP2', 'SERPINF2', 'PLAT', 'C8G', 'C2', 'CFB', 'F5', 'F10', 'F12', 'PROCR', 'CR1', 'C1QB', 'KNG1', 'KLKB1', 'F9', 'BDKRB2', 'PROC', 'F2', 'C1R', 'F2RL2', 'C9', 'C1QC', 'CD59', 'SERPINB2', 'CR2', 'C3AR1', 'SERPINE1', 'F11', 'MASP1', 'FGA', 'C4BPA', 'FGB', 'PLG', 'PROS1', 'FGG', 'F8', 'C4A', 'F7', 'PLAU', 'CFH', 'C5AR1', 'C1QA', 'VWF', 'ITGAX', 'C7', 'SERPIND1', 'C5', 'VTN', 'SERPINA1', 'C1S', 'CD55', 'CD46', 'SERPING1', 'C8A', 'BDKRB1', 'C3', 'PLAUR', 'C8B', 'F13B', 'VSIG4', 'CFI', 'TFPI', 'SERPINC1', 'C6', 'C4BPB', 'A2M', 'CFD', 'CLU', 'F2RL3', 'F13A1', 'ITGAM', 'F3', 'F2R', 'THBD', 'MBL2', 'C4B', 'ITGB2', 'CPB2', 'SERPINA5'}, 'Pertussis Homo sapiens hsa05133': {'IL1B', 'TIRAP', 'CFL2', 'NLRP3', 'TLR4', 'IL12A', 'MYD88', 'CALML6', 'RHOA', 'MAPK1', 'IL12B', 'FOS', 'NOD1', 'CFL1', 'C5', 'CXCL6', 'C2', 'TRAF6', 'C1QC', 'GNAI2', 'IRAK1', 'MAPK13', 'CASP1', 'TICAM1', 'NFKB1', 'C1S', 'C4BPB', 'TICAM2', 'MAPK14', 'MAPK8', 'RELA', 'IRF8', 'LY96', 'GNAI1', 'CASP3', 'MAPK12', 'CALM1', 'PYCARD', 'ITGB1', 'SERPING1', 'SFTPA2', 'NOS2', 'MAPK11', 'C1R', 'IL23A', 'CXCL8', 'IL6', 'C4BPA', 'CALML3', 'ITGAM', 'C3', 'IRF1', 'TNF', 'MAPK3', 'CALM3', 'IRF3', 'C4A', 'C1QB', 'ITGA5', 'JUN', 'CD14', 'GNAI3', 'MAPK9', 'C4B', 'ITGB2', 'CASP7', 'IL1A', 'SFTPA1', 'IRAK4', 'IL10', 'CXCL5', 'CALM2', 'C1QA', 'CALML5', 'MAPK10'}, 'Legionellosis Homo sapiens hsa05134': {'IL1B', 'IL12A', 'EEF1G', 'TLR4', 'HBS1L', 'CASP8', 'MYD88', 'BNIP3', 'IL12B', 'IL18', 'HSF1', 'HSPD1', 'HSPA8', 'SEC22B', 'HSPA6', 'BCL2L13', 'NAIP', 'CASP1', 'CXCL3', 'NFKB1', 'SAR1A', 'HSPA1A', 'CYCS', 'RELA', 'HSPA1B', 'HSPA1L', 'CASP3', 'PYCARD', 'RAB1A', 'NFKBIA', 'CXCL8', 'NFKB2', 'HSPA2', 'IL6', 'SAR1B', 'CXCL1', 'VCP', 'ITGAM', 'C3', 'CASP9', 'CR1', 'TNF', 'TLR2', 'EEF1A2', 'CD14', 'APAF1', 'NLRC4', 'ITGB2', 'RAB1B', 'CASP7', 'EEF1A1', 'ARF1', 'CLK1', 'CXCL2', 'TLR5'}, 'Malaria Homo sapiens hsa05144': {'IL1B', 'KLRC4-KLRK1', 'IL12A', 'TLR4', 'GYPB', 'HGF', 'IFNG', 'MYD88', 'SELP', 'KLRK1', 'IL18', 'SDC2', 'THBS1', 'ICAM1', 'HBB', 'COMP', 'MET', 'HBA2', 'SELE', 'TGFB2', 'THBS3', 'GYPC', 'THBS4', 'THBS2', 'TGFB1', 'GYPA', 'ITGAL', 'CXCL8', 'KLRB1', 'IL6', 'LRP1', 'CR1', 'TNF', 'TLR2', 'TGFB3', 'ACKR1', 'CCL2', 'CD36', 'CD81', 'CD40LG', 'PECAM1', 'HBA1', 'TLR9', 'CD40', 'CSF3', 'ITGB2', 'SDC1', 'IL10', 'VCAM1'}, 'African trypanosomiasis Homo sapiens hsa05143': {'IL1B', 'IL12A', 'MYD88', 'IFNG', 'LOC102723407', 'IL12B', 'IL18', 'APOA1', 'ICAM1', 'HBB', 'APOL1', 'PLCB2', 'IDO2', 'HBA2', 'PLCB3', 'SELE', 'IDO1', 'F2RL1', 'PLCB1', 'PRKCA', 'HPR', 'THOP1', 'IL6', 'TNF', 'FASLG', 'FAS', 'PLCB4', 'HBA1', 'GNAQ', 'TLR9', 'PRKCG', 'IL10', 'LAMA4', 'PRKCB', 'VCAM1'}, 'Regulation of autophagy Homo sapiens hsa04140': {'PIK3C3', 'ATG14', 'IFNG', 'IFNA6', 'ATG13', 'ATG4B', 'BECN1', 'ULK2', 'ATG16L1', 'IFNA7', 'ULK1', 'ATG16L2', 'ULK3', 'GABARAPL1', 'IFNA1', 'IFNA13', 'ATG5', 'IFNA8', 'ATG7', 'ATG3', 'IFNA5', 'IFNA2', 'GABARAPL2', 'IFNA10', 'PRKAA2', 'ATG4A', 'ATG10', 'ATG12', 'IFNA21', 'ATG4C', 'GABARAP', 'IFNA4', 'PIK3R4', 'INS', 'IFNA14', 'IFNA17', 'PRKAA1', 'IFNA16', 'ATG4D'}, 'Jak-STAT signaling pathway Homo sapiens hsa04630': {'IRF9', 'CISH', 'PIAS1', 'IFNG', 'STAT5B', 'PIK3R1', 'CSF2RA', 'IFNA7', 'IL12RB2', 'RAF1', 'AKT3', 'TYK2', 'LEPR', 'IL15', 'CSF2RB', 'IFNLR1', 'IFNA5', 'IL20RA', 'IL22', 'OSM', 'IFNGR2', 'STAT2', 'CCND1', 'MTOR', 'IFNA21', 'STAT3', 'PTPN2', 'CTF1', 'CCND2', 'PIK3CD', 'IL13RA2', 'STAT4', 'IL21', 'SOS2', 'LEP', 'GHR', 'IL12A', 'SOS1', 'IFNA6', 'PIAS2', 'PTPN11', 'IFNK', 'IL7', 'AKT2', 'IL5RA', 'GH1', 'IFNA1', 'STAT5A', 'IFNA13', 'IFNA8', 'IFNA2', 'IFNW1', 'IFNA10', 'IFNL2', 'IL9', 'GRB2', 'LIF', 'IL10RB', 'IFNGR1', 'CNTF', 'MCL1', 'IFNB1', 'TSLP', 'PIK3CB', 'EPO', 'IL2RB', 'IFNL3', 'CSF3', 'CNTFR', 'CSH2', 'FHL1', 'BCL2L1', 'SOCS1', 'IFNA16', 'CSF3R', 'SOCS7', 'IL12RB1', 'IL11', 'IL2RA', 'GFAP', 'IL23R', 'OSMR', 'IL13', 'PIM1', 'PIK3CA', 'IL11RA', 'PRL', 'GH2', 'IFNAR1', 'IL9R', 'PIK3R2', 'STAM2', 'IL19', 'IL6R', 'IFNA4', 'EP300', 'SOCS2', 'SOCS6', 'IFNL1', 'AOX1', 'SOCS5', 'IL3', 'PIAS3', 'STAT1', 'SOCS4', 'IL10', 'IL17D', 'IFNAR2', 'PIK3CG', 'IL20RB', 'IFNE', 'IL12B', 'EPOR', 'IL4', 'IL15RA', 'HRAS', 'PIK3R5', 'IL22RA2', 'THPO', 'IL21R', 'AKT1', 'CRLF2', 'CCND3', 'CSH1', 'BCL2', 'IL10RA', 'IL3RA', 'IL27RA', 'IL22RA1', 'IL20', 'PTPN6', 'IL24', 'IL2RG', 'IL7R', 'IL2', 'STAM', 'IL6ST', 'PIAS4', 'IL23A', 'JAK2', 'IL6', 'MYC', 'STAT6', 'IFNA14', 'MPL', 'CREBBP', 'PRLR', 'CSF2', 'IFNA17', 'LIFR', 'IL5', 'JAK3', 'IL13RA1', 'PIK3R3', 'SOCS3', 'IL4R', 'JAK1', 'CDKN1A'}, 'Cytokine-cytokine receptor interaction Homo sapiens hsa04060': {'CXCR2', 'CCL16', 'FLT4', 'IFNG', 'BMP2', 'CCL1', 'CSF2RA', 'CXCR6', 'EDAR', 'IFNA7', 'CCL14', 'IL12RB2', 'INHBB', 'FLT3', 'FIGF', 'XCL1', 'LEPR', 'CCR10', 'IL15', 'FLT3LG', 'RELT', 'CSF2RB', 'CCL4L2', 'TNFRSF9', 'CCR2', 'IFNLR1', 'LTA', 'IFNA5', 'CSF1', 'IL20RA', 'IL22', 'IFNGR2', 'TNFSF9', 'OSM', 'BMPR1A', 'IFNA21', 'CXCL8', 'ACVR1', 'CTF1', 'CXCL12', 'VEGFA', 'CCL23', 'TNF', 'CCL7', 'AMHR2', 'FASLG', 'CCL11', 'IL17RA', 'TNFRSF18', 'ACKR3', 'CCR7', 'IL21', 'TNFSF8', 'TNFRSF21', 'CCR1', 'XCL2', 'IL17RB', 'LEP', 'GHR', 'IL12A', 'IFNA6', 'NGFR', 'CCL5', 'CD70', 'CXCL2', 'IFNK', 'IL1RAP', 'IL7', 'LTB', 'PF4', 'IL5RA', 'GH1', 'IFNA1', 'ACVR1B', 'IFNA13', 'IFNA8', 'INHBE', 'TGFB2', 'CXCL3', 'IL17A', 'CCL3L3', 'IFNA2', 'IFNW1', 'TGFB1', 'IFNA10', 'TNFRSF10D', 'IFNL2', 'CXCR4', 'LIF', 'IL9', 'IL10RB', 'IFNGR1', 'CNTF', 'CCL15', 'IL25', 'IL18RAP', 'TNFRSF12A', 'KIT', 'CXCL1', 'TNFRSF11B', 'IFNB1', 'ACVR2B', 'TSLP', 'KDR', 'CXCL13', 'AMH', 'CCR4', 'CXCL10', 'CCL4', 'CCR8', 'IL1R1', 'EPO', 'IL2RB', 'IFNL3', 'CSF3', 'TNFRSF13B', 'CNTFR', 'IL1A', 'CXCL16', 'CCL19', 'CX3CR1', 'IFNA16', 'CSF3R', 'IL12RB1', 'CCR3', 'IL1B', 'IL11', 'TNFSF11', 'IL2RA', 'HGF', 'TNFRSF17', 'IL23R', 'OSMR', 'IL13', 'TNFSF14', 'TNFRSF8', 'CCL22', 'TNFRSF1B', 'CXCR1', 'CCR9', 'BMPR1B', 'TNFRSF10B', 'CXCL6', 'TNFRSF11A', 'CCL8', 'PPBP', 'IL18R1', 'PRL', 'IL11RA', 'GH2', 'IL17B', 'TNFSF15', 'CXCR3', 'IFNAR1', 'INHBC', 'IL9R', 'IL19', 'IL6R', 'CLCF1', 'TNFRSF25', 'VEGFC', 'CCL28', 'TNFSF10', 'CCL20', 'IFNA4', 'VEGFB', 'IFNL1', 'CD27', 'FAS', 'CCL3L1', 'CCL3', 'TNFRSF6B', 'CCL18', 'TNFSF4', 'CCL27', 'INHBA', 'IL3', 'IL10', 'EDA2R', 'GDF5', 'CXCR5', 'IFNAR2', 'TNFRSF10C', 'CCL13', 'IL20RB', 'IFNE', 'CSF1R', 'TGFBR1', 'CXCL14', 'IL12B', 'IL18', 'CCL25', 'TNFRSF13C', 'EPOR', 'TNFRSF1A', 'IL4', 'IL15RA', 'EGF', 'IL22RA2', 'MET', 'THPO', 'IL21R', 'XCR1', 'TNFSF12', 'CX3CL1', 'CXCL11', 'EGFR', 'CCL26', 'CRLF2', 'TNFRSF10A', 'ACVR2A', 'IL10RA', 'IL3RA', 'PF4V1', 'IL20', 'IL22RA1', 'CCL24', 'TNFSF13B', 'PDGFA', 'PDGFRB', 'PDGFC', 'PDGFB', 'CCR6', 'IL2RG', 'IL24', 'IL7R', 'KITLG', 'PLEKHO2', 'IL2', 'IL1R2', 'IL6ST', 'IL23A', 'TNFRSF4', 'IL6', 'TNFSF13', 'TGFBR2', 'IFNA14', 'MPL', 'CXCL5', 'TNFRSF14', 'TGFB3', 'PRLR', 'CSF2', 'CCL2', 'CXCL9', 'CD40LG', 'LIFR', 'IFNA17', 'IL5', 'EDA', 'BMP7', 'LTBR', 'CD40', 'TNFRSF19', 'TNFSF18', 'CCL17', 'IL13RA1', 'CCL4L1', 'IL4R', 'CCR5', 'CCL21', 'BMPR2', 'PDGFRA', 'FLT1', 'IL26'}, 'Hematopoietic cell lineage Homo sapiens hsa04640': {'HLA-DRB3', 'CSF2RA', 'FLT3', 'CD44', 'FLT3LG', 'CD2', 'CD37', 'CSF1', 'ITGA2', 'CD3E', 'CR1', 'TNF', 'CD8B', 'CD36', 'MME', 'HLA-DRB4', 'HLA-DRA', 'CD1E', 'CD34', 'IL7', 'IL5RA', 'CD59', 'CR2', 'ITGA4', 'GYPA', 'ITGB3', 'CD38', 'KIT', 'CD33', 'CD3G', 'ITGA5', 'IL1R1', 'EPO', 'CSF3', 'ANPEP', 'IL1A', 'TFRC', 'DNTT', 'CSF3R', 'CD1B', 'IL1B', 'IL11', 'FCGR1A', 'CD24', 'CD4', 'IL2RA', 'HLA-DRB1', 'ITGA3', 'CD9', 'CD22', 'ITGA1', 'IL11RA', 'CD5', 'CD3D', 'CD55', 'IL9R', 'IL6R', 'GP9', 'ITGA2B', 'HLA-DRB5', 'ITGA6', 'GP1BA', 'CD14', 'IL3', 'CSF1R', 'LOC102723407', 'MS4A1', 'CD1C', 'EPOR', 'IL4', 'CD19', 'CD1D', 'THPO', 'GP1BB', 'IL3RA', 'GP5', 'FCER2', 'IL7R', 'KITLG', 'IL1R2', 'IL6', 'ITGAM', 'CSF2', 'CD8A', 'CD7', 'IL5', 'CD1A', 'IL4R'}, 'Transcriptional misregulation in cancer Homo sapiens hsa05202': {'IGF1R', 'RUNX1T1', 'HOXA9', 'H3F3A', 'DDX5', 'HIST1H3H', 'ARNT2', 'NR4A3', 'PLAT', 'SLC45A3', 'LYL1', 'SSX2', 'ETV4', 'FLT3', 'ASPSCR1', 'ZEB1', 'PAX8', 'SMAD1', 'WHSC1', 'BCL6', 'NCOR1', 'RELA', 'JUP', 'FUS', 'CXCL8', 'MEF2C', 'ETV7', 'DDIT3', 'RXRG', 'LMO2', 'SSX2B', 'HOXA10', 'CD86', 'CCND2', 'CDK14', 'NTRK1', 'CCR7', 'HDAC1', 'CEBPE', 'ERG', 'HIST1H3D', 'NGFR', 'GRIA3', 'ATF1', 'FUT8', 'KMT2A', 'CDKN1B', 'ZBTB17', 'ELANE', 'HIST2H3A', 'RUNX1', 'DEFA3', 'SIX4', 'CCNA1', 'ELK4', 'ETV1', 'HIST1H3C', 'TCF3', 'NUPR1', 'RXRA', 'PAX7', 'SUPT3H', 'CEBPB', 'PLAU', 'DOT1L', 'FLI1', 'IL2RB', 'BMI1', 'NFKBIZ', 'KDM6A', 'PML', 'TP53', 'MDM2', 'BMP2K', 'MEIS1', 'GOLPH3L', 'HIST1H3F', 'BCL2L1', 'PBX1', 'HIST1H3E', 'FCGR1A', 'WT1', 'ITGB7', 'BIRC3', 'HPGD', 'JMJD1C', 'LDB1', 'DUSP6', 'MAF', 'ETV6', 'TLX1', 'MPO', 'HIST2H3C', 'NFKB1', 'FEV', 'H3F3C', 'MLLT3', 'EYA1', 'UTY', 'MEN1', 'BCL2A1', 'HDAC2', 'HMGA2', 'MAX', 'HIST1H3J', 'RARA', 'MLLT1', 'PRCC', 'PER2', 'HHEX', 'SIX1', 'CD14', 'HIST2H3D', 'RXRB', 'EWSR1', 'ZBTB16', 'TSPAN7', 'COMMD3-BMI1', 'SIN3A', 'IL3', 'CCNT2', 'CDKN2C', 'TAF15', 'MMP3', 'SS18', 'PAX5', 'CSF1R', 'SPI1', 'LOC102723407', 'PROM1', 'MMP9', 'CDK9', 'SPINT1', 'PTK2', 'PTCRA', 'GZMB', 'REL', 'IGFBP3', 'MET', 'MYCN', 'KLF3', 'HIST1H3I', 'SSX1', 'ETV5', 'TLX3', 'HIST1H3G', 'RUNX2', 'ATM', 'GOLPH3', 'PBX3', 'PDGFA', 'IL1R2', 'CCNT1', 'AFF1', 'TFE3', 'IL6', 'ID2', 'TMPRSS2', 'ITGAM', 'TRAF1', 'MYC', 'HIST3H3', 'TGFBR2', 'SP1', 'CEBPA', 'PAX3', 'BAIAP3', 'CSF2', 'HIST1H3A', 'FOXO1', 'MLF1', 'CD40', 'IGF1', 'WNT16', 'HOXA11', 'HIST1H3B', 'FLT1', 'PPARG', 'H3F3B', 'CDKN1A'}, 'Alcoholism Homo sapiens hsa05034': {'H2AFY2', 'SLC18A2', 'HIST2H2AB', 'H3F3A', 'HIST1H2AA', 'HIST1H3H', 'HIST1H4C', 'MAOA', 'HIST2H2BE', 'GNB3', 'GNGT2', 'GRIN2B', 'RAF1', 'GNB5', 'CREB3L4', 'SLC18A1', 'GNG5', 'ARAF', 'GNAI1', 'CALM1', 'CAMKK1', 'GRIN1', 'ADORA2A', 'HIST1H2AB', 'HIST1H4L', 'HIST2H2AA4', 'GNAO1', 'SHC4', 'HIST1H2BC', 'PPP1CA', 'BRAF', 'HDAC1', 'HDAC4', 'HIST2H4B', 'PPP1CC', 'CALML6', 'SOS2', 'H2AFV', 'CRH', 'HIST1H3D', 'GNG3', 'SOS1', 'HIST1H2BD', 'H2BFWT', 'GNG12', 'GNB2', 'HIST1H2AL', 'CREB3L1', 'DRD1', 'HIST2H4A', 'HIST1H2BJ', 'PDYN', 'HIST2H3A', 'HIST1H2BK', 'HIST1H2AI', 'HDAC8', 'HIST4H4', 'HIST1H2BB', 'GRB2', 'HIST1H3C', 'CAMKK2', 'HIST2H2AC', 'CALML3', 'GRIN2A', 'GNGT1', 'DDC', 'KRAS', 'NTRK2', 'GNG11', 'HIST1H4A', 'GRIN3B', 'HIST1H2BN', 'HDAC11', 'HIST1H4J', 'H2AFX', 'HIST1H2AC', 'HIST1H3F', 'HIST1H4D', 'CALM2', 'HIST1H2BH', 'HIST1H3E', 'BDNF', 'HIST1H2AE', 'HIST3H2A', 'HIST1H2BA', 'MAPK1', 'GNG7', 'HIST1H4G', 'HIST1H2BE', 'ADORA2B', 'H2AFB3', 'HDAC5', 'TH', 'HIST1H2BO', 'GNG10', 'GNAI2', 'HIST1H2AG', 'HIST2H3C', 'ATF4', 'HIST1H4K', 'HIST2H2BF', 'HIST1H4B', 'GNB4', 'MAP2K1', 'H3F3C', 'GRIN3A', 'CREB5', 'GNG2', 'HIST1H2BL', 'H2AFY', 'HDAC2', 'ADCY5', 'HIST1H3J', 'H2AFJ', 'HDAC7', 'NPY', 'HIST1H4I', 'SLC6A3', 'MAOB', 'CALM3', 'MAPK3', 'HIST1H2AM', 'HIST1H2BM', 'HIST2H3D', 'SLC29A1', 'GRIN2D', 'GNG8', 'HIST1H2BI', 'CREB1', 'SHC2', 'ATF2', 'HIST1H4E', 'GNG13', 'HIST1H2BF', 'PPP1CB', 'CAMK4', 'HIST2H2AA3', 'HDAC6', 'HRAS', 'H2BFM', 'SHC3', 'GNB1', 'PPP1R1B', 'SHC1', 'HIST1H2AH', 'HIST1H4H', 'HIST1H4F', 'GNG4', 'HIST1H3I', 'PKIA', 'PRKACA', 'HIST1H2AJ', 'NRAS', 'HIST1H3G', 'CREB3', 'H2AFB2', 'HDAC3', 'HAT1', 'FOSB', 'HDAC9', 'HDAC10', 'CREB3L2', 'DRD2', 'H2AFB1', 'HIST3H3', 'H2AFZ', 'ATF6B', 'HIST1H3A', 'GNAI3', 'HIST3H2BB', 'HIST1H2BG', 'HIST1H2AK', 'GRIN2C', 'GNAS', 'HIST1H2AD', 'HIST1H3B', 'H3F3B', 'CALML5', 'CREB3L3'}, 'Systemic lupus erythematosus Homo sapiens hsa05322': {'H2AFY2', 'HIST2H2AB', 'H3F3A', 'SNRPB', 'HIST1H2AA', 'IFNG', 'HIST1H3H', 'HIST1H4C', 'HLA-DRB3', 'HIST2H2BE', 'GRIN2B', 'C8G', 'C2', 'FCGR3A', 'FCGR2A', 'SNRPD3', 'TNF', 'HIST1H2AB', 'HIST1H4L', 'HIST2H2AA4', 'C1QB', 'CD86', 'SNRPD1', 'HIST1H2BC', 'HLA-DRB4', 'HLA-DRA', 'HIST2H4B', 'HLA-DMA', 'C1R', 'H2AFV', 'HIST1H3D', 'HIST1H2BD', 'H2BFWT', 'C9', 'HIST1H2AL', 'ACTN4', 'HIST2H4A', 'C1QC', 'HIST1H2BJ', 'ELANE', 'HIST2H3A', 'HIST1H2BK', 'HIST1H2AI', 'HIST4H4', 'HLA-DPB1', 'HIST1H2BB', 'HIST1H3C', 'ACTN2', 'HIST2H2AC', 'HLA-DOB', 'GRIN2A', 'C4A', 'HIST1H4A', 'HIST1H2BN', 'HIST1H4J', 'H2AFX', 'HIST1H2AC', 'HIST1H3F', 'HIST1H4D', 'HIST1H2BH', 'HIST1H3E', 'C1QA', 'HIST1H2AE', 'HIST3H2A', 'FCGR1A', 'HIST1H2BA', 'HLA-DRB1', 'SSB', 'HIST1H4G', 'CD80', 'C7', 'HIST1H2BE', 'H2AFB3', 'C5', 'HIST1H2BO', 'HIST1H2AG', 'HIST2H3C', 'HLA-DQA2', 'C1S', 'HIST1H4K', 'HIST2H2BF', 'HIST1H4B', 'H3F3C', 'HIST1H2BL', 'HLA-DMB', 'H2AFY', 'TRIM21', 'HIST1H3J', 'C8A', 'H2AFJ', 'HLA-DRB5', 'C3', 'CTSG', 'HIST1H4I', 'HIST1H2AM', 'ACTN3', 'CD28', 'C8B', 'HIST2H3D', 'HIST1H2BM', 'HLA-DOA', 'IL10', 'HIST1H2BI', 'HIST1H4E', 'HIST1H2BF', 'HLA-DQB1', 'C6', 'FCGR3B', 'LOC102723407', 'HIST2H2AA3', 'H2BFM', 'ACTN1', 'HIST1H2AH', 'HIST1H4H', 'HIST1H4F', 'HIST1H3I', 'HIST1H2AJ', 'HIST1H3G', 'H2AFB2', 'TROVE2', 'H2AFB1', 'HIST3H3', 'H2AFZ', 'HIST1H3A', 'CD40LG', 'C4B', 'HIST1H2BG', 'HIST3H2BB', 'CD40', 'HIST1H2AK', 'HIST1H2AD', 'HIST1H3B', 'HLA-DPA1', 'HLA-DQA1', 'H3F3B'}, 'Prion diseases Homo sapiens hsa05020': {'IL1B', 'NCAM1', 'SOD1', 'ELK1', 'C6', 'MAPK1', 'C9', 'CCL5', 'C7', 'EGR1', 'PRNP', 'C5', 'C8G', 'C1QC', 'HSPA5', 'BAX', 'PRKACA', 'NCAM2', 'MAP2K1', 'CASP12', 'HSPA1A', 'PRKACG', 'C8A', 'MAP2K2', 'LAMC1', 'STIP1', 'IL6', 'FYN', 'MAPK3', 'C1QB', 'NOTCH1', 'C8B', 'IL1A', 'PRKACB', 'C1QA'}, 'Inositol phosphate metabolism Homo sapiens hsa00562': {'PIK3C3', 'ITPKC', 'PI4K2A', 'PI4KB', 'MTMR1', 'MTMR4', 'IPPK', 'INPP5B', 'IMPA2', 'INPP5D', 'MTMR6', 'MINPP1', 'TPI1', 'MTMR3', 'INPPL1', 'PIP4K2B', 'PLCD1', 'MIOX', 'INPP4B', 'PLCD4', 'IMPA1', 'PLCB2', 'ITPK1', 'PIK3CA', 'PLCG2', 'PLCB3', 'INPP1', 'CDIPT', 'PIK3C2G', 'IPMK', 'INPP5A', 'PIP5K1B', 'PTEN', 'PIP5K1C', 'ITPKA', 'PIP5KL1', 'PLCB1', 'PIK3CG', 'PLCG1', 'INPP4A', 'PLCH1', 'PLCE1', 'PIP4K2A', 'MTM1', 'PIK3C2A', 'ISYNA1', 'PI4K2B', 'MTMR14', 'PIP4K2C', 'PIK3CB', 'MTMR2', 'PLCZ1', 'ALDH6A1', 'OCRL', 'PIK3CD', 'PIP5K1A', 'PLCB4', 'PIK3C2B', 'PLCH2', 'SYNJ2', 'PI4KA', 'INPP5K', 'ITPKB', 'INPP5J', 'PIKFYVE', 'SYNJ1', 'INPP5E', 'IMPAD1', 'PLCD3', 'MTMR7', 'MTMR8'}, 'Phosphatidylinositol signaling system Homo sapiens hsa04070': {'PI4KB', 'INPP5D', 'MTMR3', 'PIK3R1', 'IMPA1', 'IP6K3', 'PTEN', 'PLCG1', 'CALM1', 'INPP4A', 'ITPR3', 'PIP4K2A', 'MTM1', 'DGKA', 'PIK3C2A', 'ITPR2', 'OCRL', 'PIK3CD', 'PIP5K1A', 'PIK3C2B', 'ITPKB', 'PIKFYVE', 'CALML6', 'PLCD3', 'TMEM55A', 'MTMR4', 'ITPKC', 'IPPK', 'DGKI', 'INPP5B', 'DGKG', 'PIP4K2B', 'PLCD1', 'CDS2', 'INPP4B', 'PLCG2', 'ITPK1', 'PIK3C2G', 'INPP5A', 'PIP5K1B', 'PIP5K1C', 'PLCB1', 'ITPR1', 'DGKZ', 'CALML3', 'PIK3CB', 'PLCB4', 'DGKE', 'PPIP5K1', 'PRKCB', 'CALM2', 'MTMR8', 'PIK3C3', 'PI4K2A', 'IMPA2', 'INPPL1', 'DGKH', 'PLCB2', 'PIK3CA', 'IP6K1', 'INPP1', 'IPMK', 'DGKQ', 'ITPKA', 'PIK3R2', 'PPIP5K2', 'PLCE1', 'TMEM55B', 'PLCZ1', 'CALM3', 'CDS1', 'INPP5K', 'INPP5E', 'IP6K2', 'PLCB3', 'PIK3CG', 'MTMR1', 'MTMR6', 'DGKB', 'PIK3R5', 'PLCD4', 'CDIPT', 'DGKD', 'PRKCA', 'PI4K2B', 'MTMR14', 'PIP4K2C', 'MTMR2', 'DGKK', 'SYNJ2', 'PI4KA', 'PRKCG', 'INPP5J', 'SYNJ1', 'PIK3R3', 'IMPAD1', 'MTMR7', 'CALML5'}, 'Calcium signaling pathway Homo sapiens hsa04020': {'CHRM1', 'ADCY9', 'ADCY3', 'CACNA1I', 'ATP2B3', 'CAMK2D', 'PHKB', 'MYLK3', 'OXTR', 'CAMK2G', 'SLC8A3', 'PPP3CB', 'PTGER1', 'GNA11', 'TBXA2R', 'GNA14', 'VDAC2', 'TACR3', 'CACNA1S', 'GRM5', 'PLCG1', 'CALM1', 'CCKBR', 'PPP3R2', 'LTB4R2', 'CACNA1D', 'ITPR3', 'GRIN1', 'AVPR1B', 'ADORA2A', 'HTR2B', 'ITPR2', 'ADCY7', 'SLC25A6', 'ITPKB', 'AVPR1A', 'BDKRB2', 'STIM2', 'MYLK4', 'CACNA1E', 'PLCD3', 'CALML6', 'ATP2A3', 'ITPKC', 'PTGFR', 'CACNA1A', 'TACR1', 'ORAI3', 'CACNA1B', 'PLCD1', 'DRD1', 'ERBB4', 'CCKAR', 'PLCG2', 'RYR3', 'PTAFR', 'HTR7', 'GRPR', 'PPP3CC', 'HRH1', 'PTK2B', 'SPHK2', 'P2RX2', 'PLCB1', 'PLN', 'ITPR1', 'CAMK2B', 'CD38', 'CALML3', 'GRIN2A', 'SLC25A31', 'CACNA1G', 'AGTR1', 'CHRM5', 'SLC8A1', 'ADCY4', 'P2RX6', 'PDE1B', 'MYLK', 'TRHR', 'PLCB4', 'NOS3', 'ATP2A1', 'P2RX5', 'PRKCB', 'CALM2', 'EDNRB', 'NOS2', 'MYLK2', 'ADRA1D', 'ADORA2B', 'HTR2A', 'CYSLTR2', 'VDAC3', 'ATP2B4', 'CACNA1C', 'PLCB2', 'ADRB2', 'ADCY2', 'RYR1', 'ATP2B1', 'ADCY8', 'SLC25A4', 'P2RX1', 'PDE1A', 'ITPKA', 'TACR2', 'NOS1', 'ERBB3', 'P2RX4', 'HRH2', 'PHKA2', 'GRM1', 'SLC25A5', 'PLCE1', 'SLC8A2', 'PDE1C', 'BDKRB1', 'HTR4', 'P2RX3', 'CHRNA7', 'TNNC1', 'PHKA1', 'CHRM3', 'HTR6', 'PLCZ1', 'CALM3', 'ATP2A2', 'CAMK2A', 'PPP3R1', 'NTSR1', 'RYR2', 'GNAQ', 'ATP2B2', 'ADRA1A', 'GRIN2D', 'PPP3CA', 'ERBB2', 'ADCY1', 'DRD5', 'PLCB3', 'CYSLTR1', 'CAMK4', 'ORAI1', 'CACNA1F', 'LOC102723407', 'EDNRA', 'HTR2C', 'PPIF', 'PLCD4', 'TNNC2', 'PHKG1', 'EGFR', 'VDAC1', 'ORAI2', 'PRKACA', 'GNA15', 'PTGER3', 'PDGFRB', 'ADRB1', 'PRKACG', 'PRKCA', 'SPHK1', 'ADRB3', 'F2R', 'CACNA1H', 'GNAL', 'LHCGR', 'HTR5A', 'STIM1', 'ADRA1B', 'CHRM2', 'PHKG2', 'GRIN2C', 'PRKCG', 'GNAS', 'P2RX7', 'PRKACB', 'PDGFRA', 'CALML5'}, 'Renin secretion Homo sapiens hsa04924': {'ORAI1', 'CACNA1F', 'EDNRA', 'ADCY6', 'CLCA1', 'CLCA4', 'AQP1', 'CACNA1C', 'PLCB2', 'ADRB2', 'PLCB3', 'GNAI2', 'GUCY1A3', 'CTSB', 'PPP3CB', 'PPP3CC', 'PRKACA', 'PDE3B', 'PDE3A', 'CREB1', 'PDE1A', 'CACNA1S', 'ADRB1', 'PLCB1', 'GNAI1', 'PRKACG', 'ITPR1', 'CALM1', 'PPP3R2', 'ADCY5', 'CACNA1D', 'ITPR3', 'PDE1C', 'GUCY1A2', 'GUCY1B3', 'CALML3', 'ADRB3', 'ADCYAP1R1', 'KCNMA1', 'AGTR1', 'KCNJ2', 'ITPR2', 'CALM3', 'AGT', 'ACE', 'PTGER2', 'ADORA1', 'PRKG2', 'PDE1B', 'GNAI3', 'PLCB4', 'PPP3R1', 'CLCA2', 'GNAQ', 'REN', 'CALM2', 'GNAS', 'PPP3CA', 'PTGER4', 'PRKACB', 'NPR1', 'ADCYAP1', 'CALML6', 'CALML5'}, 'Gap junction Homo sapiens hsa04540': {'ADCY9', 'ADCY3', 'ADCY6', 'RAF1', 'TUBB3', 'GNA11', 'GRM5', 'GNAI1', 'HTR2B', 'LPAR1', 'ITPR3', 'GUCY1B3', 'TUBA8', 'ITPR2', 'ADCY7', 'PRKG2', 'SOS2', 'MAP3K2', 'SOS1', 'TUBB2B', 'TUBB2A', 'DRD1', 'GJA1', 'TUBB8', 'PDGFD', 'TUBAL3', 'PLCB1', 'GRB2', 'ITPR1', 'TUBA1C', 'TUBB1', 'KRAS', 'TUBB4B', 'ADCY4', 'CSNK1D', 'PLCB4', 'TUBA4A', 'PRKCB', 'TUBB6', 'MAPK1', 'TUBB', 'HTR2A', 'TUBA3E', 'PLCB2', 'GNAI2', 'ADCY2', 'ADCY8', 'MAP2K1', 'GRM1', 'ADCY5', 'CDK1', 'GUCY1A2', 'SRC', 'TUBA3C', 'MAPK3', 'GNAQ', 'TUBA1B', 'TUBA3D', 'ADCY1', 'PLCB3', 'HTR2C', 'HRAS', 'EGF', 'TUBB4A', 'EGFR', 'GUCY1A3', 'GJD2', 'PRKACA', 'NRAS', 'PDGFRB', 'ADRB1', 'PDGFC', 'PDGFA', 'PDGFB', 'PRKACG', 'PRKCA', 'DRD2', 'MAP2K2', 'TUBA1A', 'MAP2K5', 'PRKG1', 'GNAI3', 'MAPK7', 'TJP1', 'PRKCG', 'GNAS', 'PRKACB', 'PDGFRA'}, 'Long-term depression Homo sapiens hsa04730': {'IGF1R', 'CRH', 'CACNA1A', 'MAPK1', 'GRIA3', 'GRIA2', 'CRHR1', 'PPP2CB', 'HRAS', 'GNA12', 'PLA2G4D', 'RAF1', 'GRID2', 'PPP2CA', 'PLCB2', 'PPP1R17', 'GNAI2', 'RYR1', 'GUCY1A3', 'PLA2G4C', 'GNA11', 'NRAS', 'MAP2K1', 'PLA2G4B', 'NOS1', 'ARAF', 'PLA2G4F', 'PLCB1', 'GNAI1', 'ITPR1', 'PRKCA', 'GRM1', 'GNA13', 'ITPR3', 'PLA2G4A', 'GUCY1A2', 'MAP2K2', 'GUCY1B3', 'GRIA1', 'ITPR2', 'KRAS', 'MAPK3', 'GNAO1', 'JMJD7-PLA2G4B', 'PRKG2', 'PPP2R1A', 'PRKG1', 'PLCB4', 'GNAI3', 'PLA2G4E', 'GNAQ', 'IGF1', 'GNAZ', 'PRKCG', 'GNAS', 'PPP2R1B', 'BRAF', 'LYN', 'PRKCB', 'PLCB3'}, 'Long-term potentiation Homo sapiens hsa04720': {'PPP1CB', 'CAMK4', 'CAMK2D', 'RPS6KA6', 'MAPK1', 'GRIA2', 'PPP1CC', 'HRAS', 'CACNA1C', 'GRIN2B', 'RAF1', 'PLCB2', 'RPS6KA1', 'PLCB3', 'CAMK2G', 'RPS6KA3', 'ADCY8', 'PPP3CB', 'PPP3CC', 'ATF4', 'PRKCB', 'PRKACA', 'NRAS', 'MAP2K1', 'GRM5', 'ARAF', 'PLCB1', 'PRKACG', 'ITPR1', 'CALM1', 'PRKCA', 'CAMK2B', 'GRM1', 'PPP3R2', 'ITPR3', 'GRIN1', 'MAP2K2', 'CALML3', 'GRIA1', 'GRIN2A', 'EP300', 'ITPR2', 'CALM3', 'CREBBP', 'KRAS', 'CAMK2A', 'MAPK3', 'RAP1B', 'PPP1R1A', 'PPP3R1', 'PLCB4', 'PPP1CA', 'GNAQ', 'RPS6KA2', 'GRIN2C', 'GRIN2D', 'CALM2', 'PPP3CA', 'BRAF', 'PRKCG', 'PRKACB', 'RAP1A', 'RAPGEF3', 'CALML6', 'ADCY1', 'CALML5'}, 'GnRH signaling pathway Homo sapiens hsa04912': {'ADCY9', 'ADCY3', 'CAMK2D', 'ADCY6', 'RAF1', 'MMP2', 'FSHB', 'CAMK2G', 'PRKCD', 'MMP14', 'GNA11', 'MAPK14', 'CACNA1S', 'CALM1', 'PTK2B', 'CACNA1D', 'ITPR3', 'MAPK11', 'GNRH2', 'ITPR2', 'ADCY7', 'PLD2', 'JMJD7-PLA2G4B', 'HBEGF', 'MAP2K6', 'CALML6', 'MAP3K2', 'SOS2', 'MAPK10', 'SOS1', 'CDC42', 'MAP2K4', 'PLA2G4C', 'MAP3K1', 'PLCB1', 'GRB2', 'ITPR1', 'CAMK2B', 'PLA2G4A', 'CALML3', 'MAP2K7', 'KRAS', 'ADCY4', 'PLCB4', 'PLA2G4E', 'PRKCB', 'CALM2', 'GNRH1', 'ELK1', 'MAPK1', 'CACNA1C', 'PLCB2', 'ADCY2', 'MAPK13', 'ADCY8', 'ATF4', 'MAP2K1', 'MAPK8', 'MAP2K3', 'MAP3K4', 'GNRHR', 'ADCY5', 'SRC', 'MAPK3', 'CALM3', 'CAMK2A', 'JUN', 'MAPK9', 'GNAQ', 'ADCY1', 'PLCB3', 'CACNA1F', 'LHB', 'HRAS', 'PLA2G4D', 'EGFR', 'CGA', 'MAP3K3', 'PRKACA', 'PLD1', 'NRAS', 'PLA2G4B', 'PLA2G4F', 'PRKACG', 'MAPK12', 'PRKCA', 'MAP2K2', 'MAPK7', 'GNAS', 'PRKACB', 'CALML5'}, 'Inflammatory mediator regulation of TRP channels Homo sapiens hsa04750': {'ADCY9', 'ADCY3', 'CAMK2D', 'ADCY6', 'ASIC4', 'PIK3R1', 'CAMK2G', 'PRKCD', 'ASIC3', 'MAPK14', 'PLCG1', 'CALM1', 'HTR2B', 'ITPR3', 'MAPK11', 'ITPR2', 'ADCY7', 'JMJD7-PLA2G4B', 'PIK3CD', 'TRPV2', 'PPP1CA', 'NTRK1', 'MAP2K6', 'BDKRB2', 'PPP1CC', 'CALML6', 'PRKCE', 'MAPK10', 'IL1RAP', 'PLCG2', 'TRPV4', 'PLA2G4C', 'HRH1', 'F2RL1', 'PLCB1', 'ITPR1', 'CAMK2B', 'PLA2G4A', 'CALML3', 'PIK3CB', 'ADCY4', 'IL1R1', 'PLCB4', 'PLA2G4E', 'PRKCB', 'CALM2', 'IL1B', 'ASIC2', 'CYP2J2', 'HTR2A', 'PLCB2', 'PIK3CA', 'ADCY2', 'MAPK13', 'ADCY8', 'MAPK8', 'MAP2K3', 'TRPA1', 'PIK3R2', 'ADCY5', 'PLA2G6', 'ALOX12', 'BDKRB1', 'SRC', 'PTGER2', 'CALM3', 'CAMK2A', 'MAPK9', 'PRKCQ', 'GNAQ', 'TRPV3', 'NGF', 'ADCY1', 'PLCB3', 'PIK3CG', 'PPP1CB', 'P2RY2', 'ASIC5', 'HTR2C', 'PRKCH', 'PIK3R5', 'PLA2G4D', 'PRKACA', 'PLA2G4B', 'PLA2G4F', 'PRKACG', 'TRPV1', 'MAPK12', 'PRKCA', 'ASIC1', 'IGF1', 'PRKCG', 'GNAS', 'PTGER4', 'PRKACB', 'PIK3R3', 'TRPM8', 'CALML5'}, 'Oxytocin signaling pathway Homo sapiens hsa04921': {'KCNJ12', 'ADCY9', 'ADCY3', 'CAMK2D', 'ADCY6', 'NPR2', 'CACNG8', 'MYLK3', 'PIK3R1', 'OXTR', 'RAF1', 'CAMK2G', 'CACNA2D3', 'CACNG6', 'PPP3CB', 'NFATC1', 'CACNA2D4', 'CACNB4', 'CACNA1S', 'CACNG1', 'CACNA2D1', 'GNAI1', 'CALM1', 'CCND1', 'PPP3R2', 'CAMKK1', 'CACNA1D', 'ITPR3', 'GUCY1B3', 'MEF2C', 'CACNB3', 'KCNJ2', 'KCNJ4', 'ITPR2', 'GNAO1', 'ADCY7', 'JMJD7-PLA2G4B', 'PIK3CD', 'PPP1CA', 'MYL6B', 'PRKAG1', 'CACNG4', 'MYLK4', 'PRKAA1', 'PPP1CC', 'CALML6', 'CACNG7', 'CACNA2D2', 'CACNG3', 'RHOA', 'PRKAG3', 'RYR3', 'CACNG5', 'CACNG2', 'PLA2G4C', 'PPP3CC', 'EEF2', 'CAMK1G', 'CAMKK2', 'PRKAA2', 'KCNJ9', 'PLCB1', 'ITPR1', 'CAMK2B', 'PLA2G4A', 'CD38', 'CALML3', 'KCNJ14', 'MYL6', 'PIK3CB', 'KRAS', 'PRKAB1', 'ADCY4', 'MYLK', 'CACNB1', 'PLCB4', 'CAMK1D', 'PLA2G4E', 'NOS3', 'NPR1', 'PRKCB', 'CALM2', 'CAMK1', 'MYLK2', 'ELK1', 'MAPK1', 'MYL9', 'CACNA1C', 'PPP1R12C', 'PLCB2', 'PIK3CA', 'GNAI2', 'ADCY2', 'RYR1', 'ADCY8', 'RGS2', 'MAP2K1', 'KCNJ6', 'PIK3R2', 'ADCY5', 'NFATC2', 'GUCY1A2', 'TRPM2', 'SRC', 'PTGS2', 'MAPK3', 'CALM3', 'CAMK2A', 'JUN', 'EEF2K', 'PPP3R1', 'RYR2', 'GNAQ', 'PPP3CA', 'LOC101930123', 'ACTB', 'ADCY1', 'PLCB3', 'PIK3CG', 'NFATC4', 'PPP1R12A', 'PPP1CB', 'CAMK4', 'CACNA1F', 'PRKAG2', 'CACNB2', 'FOS', 'RCAN1', 'ROCK2', 'HRAS', 'PIK3R5', 'PLA2G4D', 'EGFR', 'GUCY1A3', 'PRKACA', 'NRAS', 'PLA2G4B', 'ROCK1', 'KCNJ3', 'PLA2G4F', 'PRKACG', 'PRKCA', 'KCNJ5', 'ACTG1', 'MAP2K2', 'OXT', 'PRKAB2', 'NFATC3', 'MAP2K5', 'GNAI3', 'MAPK7', 'PPP1R12B', 'PRKCG', 'GNAS', 'PRKACB', 'PIK3R3', 'CALML5', 'CDKN1A'}, 'Vascular smooth muscle contraction Homo sapiens hsa04270': {'ADCY9', 'ADCY3', 'KCNMB4', 'ADCY6', 'NPR2', 'RAMP1', 'MYLK3', 'PPP1R14A', 'RAF1', 'PRKCD', 'CYP4A22', 'ACTG2', 'GNA11', 'PLA2G2D', 'CACNA1S', 'ARAF', 'CALM1', 'CACNA1D', 'ITPR3', 'ADORA2A', 'AVPR1B', 'GUCY1B3', 'KCNMB2', 'ACTA2', 'PTGIR', 'KCNMA1', 'PLA2G12B', 'ITPR2', 'ADCY7', 'PLA2G3', 'JMJD7-PLA2G4B', 'ARHGEF11', 'PPP1CA', 'MYL6B', 'RAMP3', 'AVPR1A', 'BRAF', 'MYLK4', 'CALD1', 'PPP1CC', 'CALML6', 'PRKCE', 'PLA2G5', 'RHOA', 'CYP4A11', 'MRVI1', 'PLA2G2A', 'PLA2G12A', 'PLA2G2E', 'PLA2G4C', 'PLCB1', 'ITPR1', 'GNA13', 'PLA2G4A', 'CALML3', 'MYL6', 'AGTR1', 'CALCRL', 'ADCY4', 'MYLK', 'PLCB4', 'PLA2G4E', 'RAMP2', 'NPR1', 'PRKCB', 'CALM2', 'ARHGEF1', 'KCNU1', 'MYLK2', 'ADRA1D', 'MAPK1', 'MYL9', 'KCNMB3', 'ADORA2B', 'PLA2G2F', 'CACNA1C', 'PPP1R12C', 'PLCB2', 'ADCY2', 'ADCY8', 'MAP2K1', 'ADCY5', 'GUCY1A2', 'PLA2G6', 'MAPK3', 'CALM3', 'KCNMB1', 'PRKCQ', 'GNAQ', 'PLA2G1B', 'ADRA1A', 'ADCY1', 'PLCB3', 'MYH11', 'PPP1R12A', 'PPP1CB', 'CACNA1F', 'EDNRA', 'ROCK2', 'PRKCH', 'PLA2G10', 'GNA12', 'PLA2G4D', 'PLA2G2C', 'GUCY1A3', 'PRKACA', 'PLA2G4B', 'ROCK1', 'PLA2G4F', 'PRKACG', 'PRKCA', 'MAP2K2', 'PRKG1', 'ADRA1B', 'PPP1R12B', 'PRKCG', 'GNAS', 'PRKACB', 'CALML5', 'ARHGEF12'}, 'cGMP-PKG signaling pathway Homo sapiens hsa04022': {'ADCY9', 'ADCY3', 'OPRD1', 'KCNMB4', 'ATP2B3', 'ADCY6', 'NPR2', 'MYLK3', 'PIK3R1', 'PDE5A', 'RAF1', 'AKT3', 'CREB3L4', 'SLC8A3', 'PPP3CB', 'GNA11', 'NFATC1', 'PDE3A', 'MEF2D', 'VDAC2', 'ATP1B1', 'CACNA1S', 'GNAI1', 'MEF2BNB-MEF2B', 'CALM1', 'PPP3R2', 'CACNA1D', 'ITPR3', 'KCNMB2', 'GUCY1B3', 'MEF2C', 'KCNMA1', 'ITPR2', 'ADCY7', 'PRKG2', 'PIK3CD', 'PPP1CA', 'SLC25A6', 'BDKRB2', 'MYLK4', 'PPP1CC', 'CALML6', 'PRKCE', 'ATP2A3', 'INSR', 'RHOA', 'FXYD2', 'ATP1A4', 'CREB3L1', 'MRVI1', 'CNGA1', 'AKT2', 'ADRA2A', 'PPP3CC', 'PLCB1', 'PLN', 'ITPR1', 'MEF2B', 'GNA13', 'CALML3', 'SLC25A31', 'AGTR1', 'PIK3CB', 'ATP1B2', 'ATP1A1', 'SLC8A1', 'ADCY4', 'NPPB', 'MYLK', 'PLCB4', 'NOS3', 'ATP2A1', 'GATA4', 'NPR1', 'CALM2', 'GTF2IRD1', 'EDNRB', 'KCNU1', 'MYLK2', 'ADRA2B', 'ADRA1D', 'MAPK1', 'MYH7', 'MYL9', 'KCNMB3', 'VDAC3', 'ATP1A2', 'ATP2B4', 'CACNA1C', 'TRPC6', 'IRS4', 'PLCB2', 'PIK3CA', 'ADRB2', 'GNAI2', 'ADCY2', 'ATP2B1', 'ADCY8', 'ADORA3', 'ATF4', 'SLC25A4', 'RGS2', 'PDE3B', 'MAP2K1', 'PIK3R2', 'CREB5', 'ADCY5', 'SLC25A5', 'SLC8A2', 'NFATC2', 'GUCY1A2', 'INS', 'MAPK3', 'CALM3', 'ATP2A2', 'ADORA1', 'PPP3R1', 'KCNMB1', 'GNAQ', 'ATP2B2', 'ADRA1A', 'PPP3CA', 'CREB1', 'GTF2I', 'ADCY1', 'PLCB3', 'PIK3CG', 'ATF2', 'CNGB1', 'NFATC4', 'ATP1A3', 'PPP1CB', 'PPP1R12A', 'CACNA1F', 'EDNRA', 'MEF2A', 'BAD', 'ATP1B4', 'PPIF', 'ROCK2', 'GNA12', 'PIK3R5', 'AKT1', 'GUCY1A3', 'VDAC1', 'PDE2A', 'VASP', 'SRF', 'CREB3', 'ROCK1', 'ADRB1', 'IRS2', 'CREB3L2', 'MAP2K2', 'ADRB3', 'KCNJ8', 'NFATC3', 'ATF6B', 'PRKG1', 'GNAI3', 'ADRA1B', 'ATP1B3', 'ADRA2C', 'IRS1', 'PIK3R3', 'CALML5', 'CREB3L3'}, 'Adrenergic signaling in cardiomyocytes Homo sapiens hsa04261': {'PPP2R5B', 'ADCY9', 'ADCY3', 'TPM1', 'ATP2B3', 'CAMK2D', 'ADCY6', 'CACNG8', 'PIK3R1', 'AKT3', 'CREB3L4', 'CAMK2G', 'CACNA2D3', 'CACNG6', 'MYL3', 'CACNA2D4', 'CACNB4', 'MAPK14', 'ATP1B1', 'CACNA1S', 'CACNG1', 'CACNA2D1', 'GNAI1', 'KCNQ1', 'CALM1', 'MYH6', 'CACNA1D', 'TPM4', 'MAPK11', 'PPP2R2C', 'TPM3', 'CACNB3', 'ADCY7', 'PIK3CD', 'PPP1R1A', 'PPP1CA', 'ACTC1', 'PPP2R1B', 'CACNG4', 'PPP1CC', 'CALML6', 'TPM2', 'CACNG7', 'CACNA2D2', 'CACNG3', 'FXYD2', 'ATP1A4', 'CREB3L1', 'PPP2CB', 'AKT2', 'PPP2CA', 'CACNG5', 'TNNI3', 'CACNG2', 'PLCB1', 'PLN', 'PPP2R2B', 'CAMK2B', 'CALML3', 'AGTR1', 'PIK3CB', 'ATP1B2', 'ATP1A1', 'SLC8A1', 'ADCY4', 'PPP2R1A', 'CACNB1', 'PPP2R3A', 'PLCB4', 'PPP2R3B', 'SCN1B', 'CALM2', 'ADRA1D', 'MAPK1', 'AGTR2', 'MYH7', 'ATP1A2', 'ATP2B4', 'CACNA1C', 'PLCB2', 'CREM', 'PIK3CA', 'ADRB2', 'ADCY2', 'GNAI2', 'MAPK13', 'ADCY8', 'ATP2B1', 'TNNT2', 'ATF4', 'PPP2R5D', 'PIK3R2', 'CREB5', 'ADCY5', 'KCNE1', 'RPS6KA5', 'PPP2R5C', 'TNNC1', 'SLC9A1', 'CALM3', 'ATP2A2', 'CAMK2A', 'MAPK3', 'PPP2R5A', 'RYR2', 'PPP2R2A', 'GNAQ', 'ATP2B2', 'ADRA1A', 'RAPGEF3', 'CREB1', 'ADCY1', 'PLCB3', 'PIK3CG', 'ATF2', 'ATP1A3', 'PPP1CB', 'CACNA1F', 'CACNB2', 'ATP1B4', 'MYL4', 'PIK3R5', 'SCN7A', 'PPP2R5E', 'AKT1', 'BCL2', 'PRKACA', 'CREB3', 'ADRB1', 'PRKACG', 'MAPK12', 'PRKCA', 'PPP2R3C', 'CREB3L2', 'MYL2', 'SCN4B', 'ATF6B', 'GNAI3', 'ADRA1B', 'ATP1B3', 'GNAS', 'RAPGEF4', 'PRKACB', 'PIK3R3', 'PPP2R2D', 'SCN5A', 'CALML5', 'CREB3L3'}, 'cAMP signaling pathway Homo sapiens hsa04024': {'CHRM1', 'HCAR3', 'ADCY9', 'ADCY3', 'ATP2B3', 'CAMK2D', 'ADCY6', 'TIAM1', 'GPR119', 'HCAR2', 'PIK3R1', 'GRIN2B', 'OXTR', 'AKT3', 'RAF1', 'CREB3L4', 'HTR1D', 'HTR1B', 'SSTR5', 'FSHB', 'CAMK2G', 'FSHR', 'NFATC1', 'PDE3A', 'ATP1B1', 'CACNA1S', 'RELA', 'GNAI1', 'CALM1', 'CACNA1D', 'GRIN1', 'ADORA2A', 'TSHR', 'ADCY7', 'PLD2', 'PIK3CD', 'HTR1A', 'PPP1CA', 'SUCNR1', 'BRAF', 'LIPE', 'RAP1A', 'RAC1', 'PPP1CC', 'CALML6', 'ARAP3', 'MAPK10', 'SOX9', 'CFTR', 'ACOX3', 'RHOA', 'FXYD2', 'GRIA3', 'CREB3L1', 'ATP1A4', 'DRD1', 'CNGA1', 'AKT2', 'NPY1R', 'ACOX1', 'TNNI3', 'ADCY10', 'VAV2', 'VAV3', 'CNGB3', 'VIPR2', 'HTR1F', 'GABBR1', 'PLN', 'PDE4B', 'CAMK2B', 'CALML3', 'GRIN2A', 'PIK3CB', 'AMH', 'MC2R', 'ATP1B2', 'ATP1A1', 'ADCY4', 'SSTR2', 'RAP1B', 'GRIN3B', 'PTCH1', 'GRIA4', 'NPR1', 'CALM2', 'BDNF', 'GHSR', 'MAPK1', 'MYL9', 'ATP1A2', 'ATP2B4', 'CACNA1C', 'GABBR2', 'FXYD1', 'ADRB2', 'GNAI2', 'ADCY2', 'PIK3CA', 'MLLT4', 'ADCY8', 'ATP2B1', 'NFKB1', 'PDE3B', 'MAP2K1', 'MAPK8', 'GLI3', 'GRIN3A', 'PIK3R2', 'HCN4', 'CREB5', 'PDE4D', 'ADCY5', 'PLCE1', 'NFKBIA', 'NPY', 'HTR4', 'RRAS2', 'EP300', 'PPARA', 'HTR6', 'PTGER2', 'CALM3', 'SLC9A1', 'VAV1', 'CAMK2A', 'ATP2A2', 'JUN', 'ADORA1', 'MAPK3', 'RYR2', 'MAPK9', 'HCAR1', 'ATP2B2', 'GRIN2D', 'ABCC4', 'CNGA4', 'HHIP', 'RAPGEF3', 'CREB1', 'ADCY1', 'DRD5', 'PIK3CG', 'CNGB1', 'ATP1A3', 'PPP1CB', 'PPP1R12A', 'CAMK4', 'ORAI1', 'CACNA1F', 'EDNRA', 'CNGA2', 'BAD', 'FOS', 'RAC3', 'RAC2', 'ATP1B4', 'GRIA2', 'ROCK2', 'PIK3R5', 'FFAR2', 'PPP1R1B', 'AKT1', 'PRKACA', 'PLD1', 'CREB3', 'PTGER3', 'ROCK1', 'ADRB1', 'PRKACG', 'GLP1R', 'HCN2', 'CREB3L2', 'GHRL', 'CNGA3', 'ADCYAP1R1', 'GLI1', 'MAP2K2', 'DRD2', 'GRIA1', 'HTR1E', 'F2R', 'GIPR', 'PAK1', 'CREBBP', 'SSTR1', 'GNAI3', 'ATP1B3', 'CHRM2', 'GRIN2C', 'RRAS', 'GNAS', 'PDE4C', 'RAPGEF4', 'PDE4A', 'PRKACB', 'PIK3R3', 'CALML5', 'CREB3L3'}, 'Regulation of lipolysis in adipocytes Homo sapiens hsa04923': {'ADCY9', 'ADCY3', 'INSR', 'ADCY6', 'PIK3R1', 'PIK3R5', 'AKT2', 'NPY1R', 'AKT3', 'IRS4', 'PIK3CA', 'ADRB2', 'PLA2G16', 'ADCY2', 'GNAI2', 'AKT1', 'AQP7', 'ADCY8', 'PTGS1', 'CGA', 'PRKACA', 'PDE3B', 'ABHD5', 'PLIN1', 'PTGER3', 'PIK3R2', 'ADRB1', 'GNAI1', 'PRKACG', 'IRS2', 'ADCY5', 'ADRB3', 'NPY', 'INS', 'PTGS2', 'MGLL', 'PIK3CB', 'TSHR', 'ADCY4', 'ADCY7', 'ADORA1', 'PRKG2', 'PIK3CD', 'PRKG1', 'GNAI3', 'PNPLA2', 'IRS1', 'FABP4', 'GNAS', 'LIPE', 'PIK3R3', 'NPR1', 'PRKACB', 'TSHB', 'ADCY1', 'PIK3CG'}, 'Platelet activation Homo sapiens hsa04611': {'ADCY9', 'ADCY3', 'ADCY6', 'MYLK3', 'PIK3R1', 'AKT3', 'TLN2', 'TBXA2R', 'MAPK14', 'FCGR2A', 'GNAI1', 'ITPR3', 'ITGA2', 'MAPK11', 'GUCY1B3', 'PTGIR', 'GP6', 'PRKCI', 'ITPR2', 'ADCY7', 'BTK', 'PRKG2', 'JMJD7-PLA2G4B', 'PIK3CD', 'PPP1CA', 'RAP1A', 'MYLK4', 'PPP1CC', 'TLN1', 'RHOA', 'AKT2', 'PLCG2', 'PTGS1', 'PLA2G4C', 'FCER1G', 'MYL12B', 'PLCB1', 'ITPR1', 'ITGB3', 'GNA13', 'FGA', 'PLA2G4A', 'PRKCZ', 'MYL12A', 'FGB', 'RASGRP2', 'PIK3CB', 'FGG', 'P2RY1', 'ADCY4', 'RAP1B', 'MYLK', 'PLCB4', 'PLA2G4E', 'NOS3', 'ARHGEF1', 'VWF', 'MYLK2', 'MAPK1', 'PLCB2', 'PIK3CA', 'SNAP23', 'GNAI2', 'ADCY2', 'MAPK13', 'COL1A1', 'ADCY8', 'P2RX1', 'PIK3R2', 'COL3A1', 'P2RY12', 'GP9', 'ITGB1', 'ADCY5', 'GUCY1A2', 'ITGA2B', 'ARHGAP35', 'GP1BA', 'SRC', 'MAPK3', 'VAMP8', 'APBB1IP', 'GNAQ', 'TBXAS1', 'LYN', 'ACTB', 'RASGRP1', 'ADCY1', 'PLCB3', 'PIK3CG', 'PPP1R12A', 'PPP1CB', 'ORAI1', 'ROCK2', 'PIK3R5', 'PLA2G4D', 'AKT1', 'GUCY1A3', 'GP1BB', 'VASP', 'SYK', 'PRKACA', 'PLA2G4B', 'ROCK1', 'PLA2G4F', 'PRKACG', 'GP5', 'MAPK12', 'F2RL3', 'ACTG1', 'F2R', 'FYN', 'PRKG1', 'GNAI3', 'STIM1', 'LCP2', 'COL1A2', 'GNAS', 'PRKACB', 'PIK3R3', 'FERMT3', 'ARHGEF12'}, 'Chemokine signaling pathway Homo sapiens hsa04062': {'CXCR2', 'CCL16', 'ADCY9', 'ADCY3', 'ADCY6', 'STAT5B', 'TIAM1', 'CCL1', 'CHUK', 'GNB3', 'PIK3R1', 'GNGT2', 'CXCR6', 'CCL14', 'ELMO1', 'GNB5', 'RAF1', 'AKT3', 'XCL1', 'PRKCD', 'ADRBK1', 'CCR10', 'CCL4L2', 'CCR2', 'FGR', 'GNG5', 'RELA', 'GNAI1', 'STAT2', 'PTK2B', 'GRK1', 'DOCK2', 'STAT3', 'CXCL8', 'ITK', 'CXCL12', 'CCL23', 'CCL7', 'SHC4', 'ADCY7', 'CCL11', 'PIK3CD', 'GSK3B', 'CCR7', 'BRAF', 'CCR1', 'XCL2', 'RAP1A', 'GRK7', 'RAC1', 'SOS2', 'GSK3A', 'SOS1', 'GNG3', 'RHOA', 'GNG12', 'CCL5', 'GNB2', 'NFKBIB', 'CDC42', 'CXCL2', 'AKT2', 'PF4', 'CXCL3', 'VAV2', 'VAV3', 'CCL3L3', 'CXCR4', 'PLCB1', 'GRB2', 'CCL15', 'CXCL1', 'PRKCZ', 'GNGT1', 'CXCL13', 'RASGRP2', 'PIK3CB', 'CCR4', 'CXCL10', 'KRAS', 'IKBKB', 'ADCY4', 'GNG11', 'CCR8', 'RAP1B', 'PLCB4', 'PARD3', 'CXCL16', 'NCF1', 'CCL19', 'CX3CR1', 'PRKCB', 'CCR3', 'MAPK1', 'CCL22', 'GNG7', 'CXCR1', 'CCR9', 'PLCB2', 'GNG10', 'PIK3CA', 'CXCL6', 'PPBP', 'ADCY2', 'GNAI2', 'WAS', 'CCL8', 'ADCY8', 'NFKB1', 'GRK5', 'CXCR3', 'GNB4', 'MAP2K1', 'BCAR1', 'PIK3R2', 'GNG2', 'ADCY5', 'CCL28', 'NFKBIA', 'CCL20', 'SRC', 'MAPK3', 'VAV1', 'ARRB2', 'CCL3L1', 'PREX1', 'CCL18', 'CCL27', 'STAT1', 'GNG8', 'LYN', 'WASL', 'GRK4', 'SHC2', 'CXCR5', 'ADCY1', 'PLCB3', 'PIK3CG', 'GNG13', 'CCL13', 'CXCL14', 'CCL25', 'RAC2', 'PTK2', 'ROCK2', 'HRAS', 'PIK3R5', 'CCL3', 'SHC3', 'XCR1', 'CXCL11', 'GNB1', 'CX3CL1', 'SHC1', 'AKT1', 'CCL26', 'GRK6', 'GNG4', 'PRKACA', 'PF4V1', 'NRAS', 'ARRB1', 'CCL24', 'ROCK1', 'PRKACG', 'CCR6', 'HCK', 'JAK2', 'PAK1', 'IKBKG', 'CCL2', 'CXCL9', 'GNAI3', 'CRKL', 'PXN', 'JAK3', 'CRK', 'FOXO3', 'PRKACB', 'PIK3R3', 'CCL4L1', 'CXCL5', 'CCR5', 'CCL21', 'ADRBK2', 'CCL4', 'CCL17'}, 'Morphine addiction Homo sapiens hsa05032': {'GABRE', 'ADCY9', 'ADCY3', 'GABRP', 'ADCY6', 'GABRA4', 'GABRR2', 'GABRR1', 'GNB3', 'GNGT2', 'GNB5', 'GABRB3', 'ADRBK1', 'PDE3A', 'GABRB2', 'GNG5', 'GNAI1', 'GNAO1', 'PDE7A', 'ADCY7', 'GABRA1', 'PDE10A', 'CACNA1A', 'GNG3', 'GNG12', 'GNB2', 'CACNA1B', 'DRD1', 'GABRG2', 'GABBR1', 'KCNJ9', 'PDE4B', 'GNGT1', 'ADCY4', 'GNG11', 'PDE1B', 'GABRB1', 'GABRA5', 'PDE11A', 'PRKCB', 'GNG7', 'GABBR2', 'GNG10', 'GNAI2', 'ADCY2', 'ADCY8', 'GABRG3', 'GRK5', 'PDE3B', 'GNB4', 'PDE1A', 'KCNJ6', 'GNG2', 'PDE8B', 'PDE4D', 'ADCY5', 'PDE1C', 'PDE8A', 'GABRD', 'GABRA2', 'ARRB2', 'ADORA1', 'GABRR3', 'OPRM1', 'GABRG1', 'GNG8', 'GRK4', 'ADCY1', 'GNG13', 'SLC32A1', 'GNB1', 'GABRQ', 'GRK6', 'PDE2A', 'GNG4', 'PRKACA', 'ARRB1', 'PDE7B', 'KCNJ3', 'PRKACG', 'PRKCA', 'KCNJ5', 'GABRA6', 'GABRA3', 'GNAI3', 'PDE4A', 'PRKCG', 'PDE4C', 'GNAS', 'PRKACB', 'ADRBK2'}, 'GABAergic synapse Homo sapiens hsa04727': {'GABRE', 'ADCY9', 'ADCY3', 'GABRP', 'ADCY6', 'GABRA4', 'GABRR2', 'GABRR1', 'GNB3', 'GNGT2', 'GNB5', 'GABRB3', 'GABARAPL1', 'GABRB2', 'SLC38A2', 'SLC12A5', 'GNG5', 'CACNA1S', 'GNAI1', 'CACNA1D', 'HAP1', 'GNAO1', 'ADCY7', 'GABRA1', 'CACNA1A', 'GNG3', 'GPHN', 'GNG12', 'GNB2', 'SLC38A3', 'CACNA1B', 'GABRG2', 'GLS', 'ABAT', 'GABBR1', 'GNGT1', 'GAD2', 'ADCY4', 'TRAK2', 'GNG11', 'GABRB1', 'GABRA5', 'SLC38A1', 'PRKCB', 'GNG7', 'SLC6A1', 'CACNA1C', 'NSF', 'GABBR2', 'GNG10', 'GNAI2', 'ADCY2', 'ADCY8', 'GABRG3', 'GNB4', 'KCNJ6', 'PLCL1', 'GNG2', 'ADCY5', 'GLUL', 'GABARAP', 'SRC', 'SLC6A13', 'GABRA2', 'GABRD', 'GABRR3', 'GABRG1', 'SLC6A11', 'GNG8', 'GLS2', 'ADCY1', 'GAD1', 'GNG13', 'CACNA1F', 'SLC32A1', 'GNB1', 'GABRQ', 'GNG4', 'PRKACA', 'GABARAPL2', 'PRKACG', 'PRKCA', 'GABRA6', 'GABRA3', 'GNAI3', 'SLC38A5', 'PRKCG', 'PRKACB'}, 'Retrograde endocannabinoid signaling Homo sapiens hsa04723': {'GABRE', 'ADCY9', 'ADCY3', 'GABRP', 'ADCY6', 'GABRA4', 'GABRR2', 'GNB3', 'GABRR1', 'GNGT2', 'GNB5', 'GABRB3', 'GABRB2', 'MAPK14', 'GRM5', 'CACNA1S', 'GNG5', 'GNAI1', 'CACNA1D', 'ITPR3', 'MAPK11', 'ITPR2', 'GNAO1', 'ADCY7', 'GABRA1', 'MAPK10', 'CACNA1A', 'GNG3', 'GNG12', 'GNB2', 'GRIA3', 'CACNA1B', 'GABRG2', 'PLCB1', 'KCNJ9', 'ITPR1', 'GNGT1', 'SLC17A6', 'ADCY4', 'GNG11', 'GABRB1', 'RIMS1', 'PLCB4', 'GABRA5', 'GRIA4', 'PRKCB', 'MAPK1', 'GNG7', 'CACNA1C', 'PLCB2', 'GNG10', 'CNR1', 'GNAI2', 'ADCY2', 'MAPK13', 'ADCY8', 'GABRG3', 'GNB4', 'MAPK8', 'KCNJ6', 'GNG2', 'GRM1', 'ADCY5', 'ABHD6', 'PTGS2', 'GABRD', 'GABRA2', 'MAPK3', 'GABRR3', 'MAPK9', 'GNAQ', 'GABRG1', 'GNG8', 'ADCY1', 'PLCB3', 'GNG13', 'CACNA1F', 'SLC17A7', 'GRIA2', 'SLC32A1', 'DAGLB', 'GNB1', 'GABRQ', 'GNG4', 'PRKACA', 'KCNJ3', 'PRKACG', 'MAPK12', 'PRKCA', 'FAAH', 'KCNJ5', 'GRIA1', 'GABRA6', 'MGLL', 'GABRA3', 'NAPEPLD', 'DAGLA', 'GNAI3', 'PRKCG', 'SLC17A8', 'PRKACB'}, 'Glutamatergic synapse Homo sapiens hsa04724': {'ADCY9', 'ADCY3', 'ADCY6', 'GRIK2', 'GNB3', 'GNGT2', 'GRIN2B', 'GNB5', 'GRIK4', 'GRM4', 'ADRBK1', 'PPP3CB', 'SLC38A2', 'GRM5', 'GNG5', 'GNAI1', 'PPP3R2', 'CACNA1D', 'ITPR3', 'GRIN1', 'GRIK1', 'ITPR2', 'GNAO1', 'ADCY7', 'PLD2', 'JMJD7-PLA2G4B', 'GRM3', 'SLC1A3', 'CACNA1A', 'GNG3', 'GNG12', 'GNB2', 'SLC38A3', 'GRIA3', 'GLS', 'PLA2G4C', 'PPP3CC', 'HOMER3', 'PLCB1', 'HOMER2', 'ITPR1', 'PLA2G4A', 'GRM7', 'GRIN2A', 'GNGT1', 'SLC17A6', 'ADCY4', 'GNG11', 'GRIN3B', 'PLCB4', 'PLA2G4E', 'SLC38A1', 'GRIA4', 'GRIK5', 'SHANK1', 'PRKCB', 'DLGAP1', 'MAPK1', 'GNG7', 'SLC1A2', 'CACNA1C', 'PLCB2', 'GNG10', 'GNAI2', 'ADCY2', 'SLC1A1', 'ADCY8', 'GNB4', 'TRPC1', 'GRIN3A', 'GNG2', 'GRM1', 'ADCY5', 'GLUL', 'MAPK3', 'PPP3R1', 'GNAQ', 'SLC1A7', 'GRIN2D', 'SLC1A6', 'PPP3CA', 'GNG8', 'GLS2', 'ADCY1', 'PLCB3', 'GNG13', 'SLC17A7', 'GRIA2', 'PLA2G4D', 'GNB1', 'GNG4', 'PRKACA', 'GRIK3', 'SHANK3', 'PLD1', 'PLA2G4B', 'GRM6', 'KCNJ3', 'DLG4', 'PLA2G4F', 'PRKACG', 'PRKCA', 'GRM8', 'HOMER1', 'GRIA1', 'SHANK2', 'GNAI3', 'GRM2', 'GRIN2C', 'PRKCG', 'GNAS', 'SLC17A8', 'PRKACB', 'ADRBK2'}, 'Circadian entrainment Homo sapiens hsa04713': {'ADCY9', 'ADCY3', 'CACNA1I', 'CAMK2D', 'ADCY6', 'GNB3', 'GNGT2', 'GRIN2B', 'GNB5', 'PER3', 'CAMK2G', 'RASD1', 'GNG5', 'GNAI1', 'CALM1', 'CACNA1D', 'ITPR3', 'GRIN1', 'GUCY1B3', 'GNAO1', 'ADCY7', 'PRKG2', 'CALML6', 'PER1', 'GNG3', 'GNG12', 'GNB2', 'GRIA3', 'RYR3', 'ADCY10', 'MTNR1A', 'PLCB1', 'KCNJ9', 'ITPR1', 'CAMK2B', 'CALML3', 'GRIN2A', 'CACNA1G', 'GNGT1', 'ADCY4', 'GNG11', 'PLCB4', 'GRIA4', 'PRKCB', 'CALM2', 'MAPK1', 'GNG7', 'CACNA1C', 'PLCB2', 'GNG10', 'GNAI2', 'ADCY2', 'RYR1', 'ADCY8', 'GNB4', 'KCNJ6', 'NOS1', 'GNG2', 'ADCY5', 'GUCY1A2', 'RPS6KA5', 'PER2', 'MAPK3', 'CALM3', 'CAMK2A', 'RYR2', 'GNAQ', 'GRIN2D', 'GNG8', 'CREB1', 'ADCY1', 'PLCB3', 'GNG13', 'NOS1AP', 'FOS', 'GRIA2', 'GNB1', 'GUCY1A3', 'MTNR1B', 'GNG4', 'PRKACA', 'KCNJ3', 'PRKACG', 'PRKCA', 'KCNJ5', 'ADCYAP1R1', 'GRIA1', 'CACNA1H', 'PRKG1', 'GNAI3', 'GRIN2C', 'PRKCG', 'GNAS', 'PRKACB', 'CALML5'}, 'Dopaminergic synapse Homo sapiens hsa04728': {'SLC18A2', 'PPP2R5B', 'ARNTL', 'CAMK2D', 'MAOA', 'GNB3', 'GNGT2', 'GRIN2B', 'AKT3', 'GNB5', 'CREB3L4', 'CAMK2G', 'PPP3CB', 'MAPK14', 'SLC18A1', 'GNG5', 'GNAI1', 'CALM1', 'CACNA1D', 'ITPR3', 'MAPK11', 'PPP2R2C', 'ITPR2', 'GNAO1', 'GSK3B', 'PPP1CA', 'PPP2R1B', 'PPP1CC', 'CALML6', 'GSK3A', 'MAPK10', 'CACNA1A', 'GNG3', 'GNG12', 'GNB2', 'KIF5B', 'GRIA3', 'CACNA1B', 'CREB3L1', 'DRD1', 'PPP2CB', 'AKT2', 'PPP2CA', 'PPP3CC', 'CALY', 'PLCB1', 'KCNJ9', 'PPP2R2B', 'ITPR1', 'CAMK2B', 'CALML3', 'GRIN2A', 'GNGT1', 'DDC', 'GNG11', 'PPP2R1A', 'PLCB4', 'PPP2R3A', 'COMT', 'PPP2R3B', 'GRIA4', 'PRKCB', 'CALM2', 'CLOCK', 'GNG7', 'CACNA1C', 'TH', 'PLCB2', 'GNG10', 'GNAI2', 'MAPK13', 'ATF4', 'PPP2R5D', 'GNB4', 'MAPK8', 'KCNJ6', 'CREB5', 'GNG2', 'KIF5A', 'ADCY5', 'PPP2R5C', 'SLC6A3', 'MAOB', 'CALM3', 'CAMK2A', 'ARRB2', 'PPP2R5A', 'MAPK9', 'PPP2R2A', 'GNAQ', 'PPP3CA', 'GNG8', 'CREB1', 'DRD5', 'PLCB3', 'ATF2', 'GNG13', 'PPP1CB', 'FOS', 'GRIA2', 'KIF5C', 'PPP2R5E', 'GNB1', 'PPP1R1B', 'AKT1', 'GNG4', 'PRKACA', 'DRD3', 'CREB3', 'KCNJ3', 'SCN1A', 'PRKACG', 'MAPK12', 'PRKCA', 'KCNJ5', 'CREB3L2', 'PPP2R3C', 'DRD2', 'GRIA1', 'GNAL', 'ATF6B', 'GNAI3', 'DRD4', 'PRKCG', 'GNAS', 'PRKACB', 'PPP2R2D', 'CALML5', 'CREB3L3'}, 'Serotonergic synapse Homo sapiens hsa04726': {'SLC18A2', 'CYP4X1', 'MAOA', 'GNB3', 'GNGT2', 'HTR1D', 'RAF1', 'GNB5', 'CYP2C9', 'HTR1B', 'GABRB3', 'CYP2C8', 'ALOX5', 'GABRB2', 'SLC18A1', 'CACNA1S', 'GNG5', 'TPH2', 'ARAF', 'GNAI1', 'APP', 'HTR2B', 'CACNA1D', 'ITPR3', 'ITPR2', 'GNAO1', 'JMJD7-PLA2G4B', 'HTR1A', 'BRAF', 'CACNA1A', 'GNG3', 'HTR3D', 'GNG12', 'GNB2', 'CACNA1B', 'HTR3A', 'CYP2D6', 'KCNN2', 'HTR7', 'PTGS1', 'ALOX12B', 'PLA2G4C', 'HTR1F', 'PLCB1', 'KCNJ9', 'ITPR1', 'PLA2G4A', 'ALOX15', 'GNGT1', 'DDC', 'KRAS', 'GNG11', 'HTR3C', 'GABRB1', 'PLCB4', 'PLA2G4E', 'HTR3E', 'PRKCB', 'MAPK1', 'GNG7', 'CYP2J2', 'TPH1', 'HTR2A', 'ALOX15B', 'CACNA1C', 'PLCB2', 'GNG10', 'DUSP1', 'GNAI2', 'SLC6A4', 'GNB4', 'TRPC1', 'MAP2K1', 'KCNJ6', 'GNG2', 'ADCY5', 'ALOX12', 'HTR4', 'PTGS2', 'CYP2C19', 'HTR6', 'MAOB', 'MAPK3', 'GNAQ', 'GNG8', 'RAPGEF3', 'PLCB3', 'GNG13', 'CACNA1F', 'HTR2C', 'HRAS', 'PLA2G4D', 'GNB1', 'KCND2', 'CYP2C18', 'GNG4', 'PRKACA', 'NRAS', 'PLA2G4B', 'KCNJ3', 'PLA2G4F', 'PRKACG', 'CASP3', 'PRKCA', 'KCNJ5', 'HTR1E', 'HTR5A', 'HTR3B', 'GNAI3', 'PRKCG', 'GNAS', 'PRKACB'}, 'Cholinergic synapse Homo sapiens hsa04725': {'CHRM1', 'KCNQ4', 'KCNJ12', 'ADCY9', 'ADCY3', 'CAMK2D', 'ADCY6', 'GNB3', 'PIK3R1', 'GNGT2', 'AKT3', 'GNB5', 'CREB3L4', 'CAMK2G', 'CHAT', 'GNA11', 'CACNA1S', 'GNG5', 'GNAI1', 'KCNQ1', 'CACNA1D', 'ITPR3', 'CHRNA3', 'KCNJ2', 'KCNJ4', 'ITPR2', 'GNAO1', 'ADCY7', 'PIK3CD', 'KCNQ2', 'CACNA1A', 'GNG3', 'GNG12', 'GNB2', 'CACNA1B', 'CREB3L1', 'CHRNA4', 'AKT2', 'ACHE', 'SLC18A3', 'PLCB1', 'ITPR1', 'CAMK2B', 'KCNJ14', 'GNGT1', 'PIK3CB', 'KRAS', 'CHRM5', 'ADCY4', 'GNG11', 'PLCB4', 'CHRNA6', 'PRKCB', 'MAPK1', 'GNG7', 'CHRM4', 'CHRNB2', 'CACNA1C', 'PLCB2', 'GNG10', 'PIK3CA', 'GNAI2', 'ADCY2', 'CHRNB4', 'ADCY8', 'ATF4', 'GNB4', 'MAP2K1', 'KCNJ6', 'PIK3R2', 'CREB5', 'GNG2', 'ADCY5', 'CHRNA7', 'CHRM3', 'MAPK3', 'CAMK2A', 'GNAQ', 'GNG8', 'CREB1', 'ADCY1', 'PLCB3', 'PIK3CG', 'GNG13', 'CAMK4', 'CACNA1F', 'KCNQ5', 'FOS', 'HRAS', 'PIK3R5', 'GNB1', 'AKT1', 'BCL2', 'GNG4', 'PRKACA', 'NRAS', 'CREB3', 'KCNJ3', 'PRKACG', 'PRKCA', 'CREB3L2', 'JAK2', 'SLC5A7', 'FYN', 'GNAI3', 'KCNQ3', 'CHRM2', 'PRKCG', 'PRKACB', 'PIK3R3', 'CREB3L3'}, 'Estrogen signaling pathway Homo sapiens hsa04915': {'ADCY9', 'ADCY3', 'ADCY6', 'PIK3R1', 'RAF1', 'AKT3', 'CREB3L4', 'MMP2', 'PRKCD', 'GPER1', 'ESR2', 'GNAI1', 'CALM1', 'ITPR3', 'HSPA2', 'ITPR2', 'SHC4', 'GNAO1', 'ADCY7', 'HSP90AB1', 'PIK3CD', 'FKBP4', 'HBEGF', 'CALML6', 'SOS2', 'SOS1', 'CREB3L1', 'AKT2', 'ESR1', 'HSP90B1', 'HSPA1A', 'HSPA1B', 'GABBR1', 'GRB2', 'FKBP5', 'KCNJ9', 'ITPR1', 'PLCB1', 'CALML3', 'PIK3CB', 'KRAS', 'ADCY4', 'HSP90AA1', 'PLCB4', 'NOS3', 'CALM2', 'MAPK1', 'HSPA8', 'GABBR2', 'PLCB2', 'PIK3CA', 'GNAI2', 'ADCY2', 'HSPA6', 'ADCY8', 'ATF4', 'MAP2K1', 'KCNJ6', 'PIK3R2', 'CREB5', 'GRM1', 'ADCY5', 'SRC', 'MAPK3', 'CALM3', 'JUN', 'GNAQ', 'OPRM1', 'CREB1', 'SHC2', 'ADCY1', 'PLCB3', 'PIK3CG', 'ATF2', 'MMP9', 'FOS', 'HRAS', 'PIK3R5', 'SHC3', 'EGFR', 'SHC1', 'AKT1', 'PRKACA', 'NRAS', 'CREB3', 'KCNJ3', 'HSPA1L', 'PRKACG', 'KCNJ5', 'CREB3L2', 'MAP2K2', 'SP1', 'ATF6B', 'GNAI3', 'GNAS', 'PRKACB', 'PIK3R3', 'CALML5', 'CREB3L3'}, 'Aldosterone synthesis and secretion Homo sapiens hsa04925': {'PRKD3', 'ADCY9', 'ADCY3', 'CACNA1I', 'CAMK2D', 'ADCY6', 'CREB3L4', 'NR4A1', 'CAMK2G', 'GNA11', 'CACNA1S', 'CALM1', 'CACNA1D', 'ITPR3', 'ITPR2', 'ADCY7', 'CYP21A2', 'LIPE', 'CALML6', 'PRKCE', 'CYP11B2', 'CREB3L1', 'KCNK3', 'ATF1', 'PRKD2', 'CAMK1G', 'PLCB1', 'ITPR1', 'CAMK2B', 'KCNK9', 'CALML3', 'CACNA1G', 'AGTR1', 'MC2R', 'ADCY4', 'PLCB4', 'CAMK1D', 'NPR1', 'CAMK1', 'PRKCB', 'CALM2', 'STAR', 'CACNA1C', 'PLCB2', 'ADCY2', 'ADCY8', 'ATF4', 'NR4A2', 'CREB5', 'ADCY5', 'CALM3', 'CAMK2A', 'LDLR', 'GNAQ', 'CREB1', 'PRKD1', 'ADCY1', 'PLCB3', 'ATF2', 'CAMK4', 'ORAI1', 'CACNA1F', 'HSD3B2', 'DAGLB', 'CYP11A1', 'SCARB1', 'PDE2A', 'PRKACA', 'CREB3', 'HSD3B1', 'PRKACG', 'PRKCA', 'CREB3L2', 'CACNA1H', 'DAGLA', 'ATF6B', 'PRKCG', 'GNAS', 'PRKACB', 'CALML5', 'CREB3L3'}, 'Insulin secretion Homo sapiens hsa04911': {'ADCY9', 'ADCY3', 'KCNMB4', 'CAMK2D', 'ADCY6', 'GPR119', 'PCLO', 'CREB3L4', 'CAMK2G', 'GNA11', 'ATP1B1', 'CACNA1S', 'CACNA1D', 'ITPR3', 'KCNMB2', 'KCNMA1', 'ADCY7', 'STX1A', 'SLC2A2', 'TRPM4', 'FXYD2', 'RIMS2', 'ATP1A4', 'CREB3L1', 'PDX1', 'CCKAR', 'KCNN2', 'PLCB1', 'CAMK2B', 'ATP1B2', 'ATP1A1', 'ADCY4', 'PLCB4', 'VAMP2', 'KCNN1', 'GCG', 'PRKCB', 'KCNU1', 'KCNMB3', 'ATP1A2', 'CACNA1C', 'PLCB2', 'GCK', 'ADCY2', 'ADCY8', 'ATF4', 'CREB5', 'ADCY5', 'INS', 'CHRM3', 'CAMK2A', 'KCNMB1', 'RYR2', 'GNAQ', 'SLC2A1', 'KCNN3', 'CREB1', 'ADCY1', 'PLCB3', 'ATF2', 'GIP', 'ATP1A3', 'FFAR1', 'CACNA1F', 'ATP1B4', 'PRKACA', 'KCNJ11', 'KCNN4', 'CREB3', 'GLP1R', 'PRKACG', 'PRKCA', 'RAB3A', 'CREB3L2', 'SNAP25', 'ADCYAP1R1', 'ATF6B', 'ATP1B3', 'ABCC8', 'PRKCG', 'GNAS', 'RAPGEF4', 'PRKACB', 'ADCYAP1', 'CREB3L3'}, 'Thyroid hormone synthesis Homo sapiens hsa04918': {'ATF2', 'PDIA4', 'ATP1A3', 'ADCY3', 'TG', 'ADCY9', 'ASGR1', 'TPO', 'FXYD2', 'ADCY6', 'ATP1B4', 'ATP1A4', 'CREB3L1', 'TTF2', 'GPX1', 'SLC26A4', 'ATP1A2', 'TTF1', 'PLCB2', 'CREB3L4', 'HSP90B1', 'PAX8', 'ADCY2', 'GPX3', 'HSPA5', 'ADCY8', 'ASGR2', 'CGA', 'ATF4', 'PRKACA', 'CREB1', 'CREB3', 'ATP1B1', 'SLC5A5', 'IYD', 'CREB5', 'PLCB1', 'PRKACG', 'ITPR1', 'PRKCA', 'CANX', 'ADCY5', 'CREB3L2', 'ITPR3', 'GPX8', 'DUOX2', 'LRP2', 'GPX7', 'GPX6', 'DUOXA2', 'ITPR2', 'ATP1B2', 'CREB3L3', 'TSHR', 'ADCY4', 'ADCY7', 'ATF6B', 'PLCB4', 'GNAQ', 'GPX2', 'GSR', 'ATP1B3', 'PRKCG', 'GNAS', 'GPX5', 'PRKACB', 'TSHB', 'PRKCB', 'ADCY1', 'PLCB3', 'ATP1A1'}, 'Gastric acid secretion Homo sapiens hsa04971': {'KCNJ1', 'CA2', 'MYLK2', 'CFTR', 'ATP1A3', 'ADCY3', 'ADCY9', 'KCNE2', 'CAMK2D', 'ADCY6', 'ATP1B4', 'SST', 'ATP1A4', 'MYLK3', 'ATP4B', 'ATP1A2', 'KCNJ15', 'PLCB2', 'PLCB3', 'ADCY2', 'GNAI2', 'CAMK2G', 'ADCY8', 'ATP4A', 'EZR', 'PRKACA', 'PRKCB', 'SLC4A2', 'ATP1B1', 'PLCB1', 'SLC26A7', 'HRH2', 'GNAI1', 'ITPR1', 'CALM1', 'PRKCA', 'ADCY5', 'KCNQ1', 'CCKBR', 'ITPR3', 'CAMK2B', 'SLC9A4', 'CALML3', 'KCNJ10', 'CHRM3', 'KCNJ2', 'ITPR2', 'ATP1B2', 'CALM3', 'SLC9A1', 'ADCY4', 'ADCY7', 'CAMK2A', 'GAST', 'SSTR2', 'KCNK10', 'MYLK', 'PLCB4', 'GNAI3', 'GNAQ', 'PRKACG', 'KCNK2', 'ATP1B3', 'CALM2', 'PRKCG', 'GNAS', 'PRKACB', 'MYLK4', 'KCNJ16', 'CALML6', 'ACTB', 'ADCY1', 'CALML5', 'ATP1A1'}, 'Salivary secretion Homo sapiens hsa04970': {'ADCY9', 'ADCY3', 'ATP2B3', 'ADCY6', 'SLC12A2', 'MUC5B', 'AQP5', 'CST1', 'ATP1B1', 'DMBT1', 'CALM1', 'ITPR3', 'GUCY1B3', 'TRPV6', 'KCNMA1', 'ITPR2', 'ADCY7', 'PRKG2', 'CAMP', 'CALML6', 'MUC7', 'BST1', 'FXYD2', 'ATP1A4', 'HTN3', 'RYR3', 'BEST2', 'PLCB1', 'ITPR1', 'CD38', 'CALML3', 'AMY1A', 'ATP1B2', 'ADCY4', 'STATH', 'PLCB4', 'PRB2', 'VAMP2', 'PRKCB', 'CALM2', 'ADRA1D', 'ATP1A2', 'ATP2B4', 'PLCB2', 'CST5', 'CST3', 'ADRB2', 'ADCY2', 'ATP2B1', 'ADCY8', 'NOS1', 'ADCY5', 'GUCY1A2', 'AMY1B', 'CHRM3', 'PRB1', 'SLC9A1', 'CALM3', 'CST2', 'PRH1', 'LPO', 'GNAQ', 'ATP2B2', 'ADRA1A', 'PRH2', 'ADCY1', 'PLCB3', 'ATP1A3', 'ATP1B4', 'AMY1C', 'CST4', 'GUCY1A3', 'PRKACA', 'SLC4A2', 'KCNN4', 'ADRB1', 'PRKACG', 'PRKCA', 'HTN1', 'ADRB3', 'LYZ', 'PRKG1', 'ADRA1B', 'ATP1B3', 'PRKCG', 'GNAS', 'PRKACB', 'CALML5', 'ATP1A1'}, 'Pancreatic secretion Homo sapiens hsa04972': {'SLC4A4', 'CA2', 'CPA3', 'ADCY9', 'ADCY3', 'ATP2B3', 'ADCY6', 'SLC12A2', 'RAB27B', 'PLA2G2D', 'ATP1B1', 'CELA3A', 'KCNQ1', 'AMY2B', 'ITPR3', 'KCNMA1', 'PLA2G12B', 'ITPR2', 'ADCY7', 'PLA2G3', 'CPA2', 'RAP1A', 'RAC1', 'ATP2A3', 'PLA2G5', 'CFTR', 'PNLIP', 'BST1', 'RAB8A', 'RHOA', 'FXYD2', 'CLCA1', 'ATP1A4', 'CCKAR', 'PNLIPRP2', 'PLA2G2A', 'PLA2G12A', 'PLA2G2E', 'SCTR', 'PNLIPRP1', 'PLCB1', 'ITPR1', 'CD38', 'ATP1B2', 'ADCY4', 'RAP1B', 'TPCN2', 'PLCB4', 'ATP2A1', 'RAB11A', 'PRKCB', 'PRSS1', 'PLA2G2F', 'ATP1A2', 'ATP2B4', 'PRSS3', 'PLCB2', 'ADCY2', 'ATP2B1', 'ADCY8', 'RAB3D', 'TRPC1', 'CELA2B', 'ADCY5', 'SLC26A3', 'CHRM3', 'SLC9A1', 'ATP2A2', 'CLCA2', 'RYR2', 'GNAQ', 'ATP2B2', 'PLA2G1B', 'PRSS2', 'CELA3B', 'ADCY1', 'PLCB3', 'ATP1A3', 'CTRB1', 'CPA1', 'CLCA4', 'ATP1B4', 'PLA2G10', 'PLA2G2C', 'SLC4A2', 'CEL', 'CTRL', 'PRKCA', 'AMY2A', 'CELA2A', 'CPB1', 'ATP1B3', 'PRKCG', 'GNAS', 'CPB2', 'ATP1A1'}, 'Endocrine and other factor-regulated calcium reabsorption Homo sapiens hsa04961': {'ATP1A3', 'AP2B1', 'ADCY9', 'FXYD2', 'ADCY6', 'ATP1B4', 'ATP1A4', 'CLTA', 'ATP1A2', 'ESR1', 'PLCB2', 'DNM2', 'ATP2B1', 'KLK1', 'PRKACA', 'DNM1', 'ATP1B1', 'KL', 'CLTCL1', 'PLCB1', 'CLTB', 'PRKACG', 'PRKCA', 'AP2S1', 'PTH1R', 'CALB1', 'AP2M1', 'ATP1B2', 'DNM3', 'KLK2', 'SLC8A1', 'CLTC', 'VDR', 'PLCB4', 'GNAQ', 'AP2A2', 'ATP1B3', 'PRKCG', 'GNAS', 'BDKRB2', 'TRPV5', 'AP2A1', 'RAB11A', 'PRKACB', 'PRKCB', 'PLCB3', 'ATP1A1'}, 'Bile secretion Homo sapiens hsa04976': {'SLC4A4', 'CA2', 'SLC10A1', 'CFTR', 'AQP9', 'ADCY3', 'ATP1A3', 'SLC9A3', 'ADCY9', 'SLC22A1', 'NR1H4', 'FXYD2', 'ADCY6', 'ATP1B4', 'ABCG5', 'ATP1A4', 'ABCC2', 'ATP1A2', 'AQP1', 'SLC27A5', 'ADCY1', 'ABCB11', 'KCNN2', 'ADCY2', 'SLCO1B3', 'EPHX1', 'SCARB1', 'ADCY8', 'SCTR', 'PRKACA', 'SLC4A2', 'ABCG8', 'ABCB1', 'NR0B2', 'ATP1B1', 'ABCC3', 'BAAT', 'PRKACG', 'ADCY5', 'SLCO1A2', 'ABCB4', 'RXRA', 'AQP8', 'NCEH1', 'SLC9A1', 'ATP1B2', 'SLCO1B1', 'SLC51B', 'ADCY4', 'ABCG2', 'ADCY7', 'LDLR', 'UGT2B4', 'SLC10A2', 'SLC22A7', 'SLC5A1', 'CYP3A4', 'SULT2A1', 'SLC2A1', 'ATP1B3', 'SLC51A', 'CYP7A1', 'AQP4', 'GNAS', 'SLC22A8', 'ABCC4', 'SLC4A5', 'PRKACB', 'HMGCR', 'SLCO1B7', 'ATP1A1'}, 'Ovarian steroidogenesis Homo sapiens hsa04913': {'IGF1R', 'ADCY9', 'ADCY3', 'INSR', 'ADCY6', 'CYP2J2', 'CYP1A1', 'BMP15', 'LHB', 'HSD17B2', 'HSD3B2', 'ACOT2', 'CYP1B1', 'STAR', 'PLA2G4D', 'GDF9', 'CYP11A1', 'FSHB', 'ADCY2', 'SCARB1', 'CYP17A1', 'ADCY8', 'ALOX5', 'CGA', 'FSHR', 'PLA2G4C', 'AKR1C3', 'PRKACA', 'PLA2G4B', 'BMP6', 'HSD3B1', 'PLA2G4F', 'PRKACG', 'ADCY5', 'PLA2G4A', 'HSD17B7', 'INS', 'PTGS2', 'ADCY4', 'ADCY7', 'LDLR', 'LHCGR', 'JMJD7-PLA2G4B', 'CYP19A1', 'PLA2G4E', 'IGF1', 'HSD17B1', 'GNAS', 'PRKACB', 'ADCY1'}, 'Vasopressin-regulated water reabsorption Homo sapiens hsa04962': {'DYNC1LI1', 'RAB5A', 'ADCY9', 'ADCY3', 'DCTN1', 'RAB5C', 'ADCY6', 'AQP3', 'DYNC1I1', 'CREB3L1', 'ARHGDIB', 'DCTN6', 'DYNC2LI1', 'NSF', 'CREB3L4', 'DYNC1H1', 'ARHGDIA', 'PRKACA', 'DYNLL1', 'DYNC1LI2', 'CREB3', 'DYNC2H1', 'CREB5', 'RAB5B', 'PRKACG', 'ARHGDIG', 'DYNC1I2', 'RAB11B', 'CREB3L2', 'DYNLL2', 'DCTN2', 'AVP', 'AVPR2', 'DCTN5', 'VAMP2', 'AQP4', 'GNAS', 'DCTN4', 'AQP2', 'RAB11A', 'PRKACB', 'STX4', 'CREB1', 'CREB3L3'}, 'Cocaine addiction Homo sapiens hsa05030': {'ATF2', 'SLC18A2', 'CDK5', 'MAOA', 'GRIA2', 'CREB3L1', 'DRD1', 'GRIN2B', 'TH', 'CREB3L4', 'PPP1R1B', 'GNAI2', 'PDYN', 'NFKB1', 'ATF4', 'PRKACA', 'GPSM1', 'CDK5R1', 'CREB3', 'SLC18A1', 'GRIN3A', 'RELA', 'DLG4', 'CREB5', 'GNAI1', 'PRKACG', 'FOSB', 'RGS9', 'ADCY5', 'CREB3L2', 'GRIN1', 'DRD2', 'GRIN2A', 'DDC', 'SLC6A3', 'MAOB', 'CREB3L3', 'JUN', 'ATF6B', 'GRIN3B', 'GNAI3', 'GRM3', 'GRM2', 'GRIN2D', 'GRIN2C', 'GNAS', 'PRKACB', 'CREB1', 'BDNF'}, 'Amphetamine addiction Homo sapiens hsa05031': {'ATF2', 'SLC18A2', 'PPP1CB', 'CAMK4', 'CAMK2D', 'MAOA', 'FOS', 'GRIA2', 'GRIA3', 'CREB3L1', 'DRD1', 'CACNA1C', 'GRIN2B', 'TH', 'CREB3L4', 'PPP1R1B', 'CAMK2G', 'PDYN', 'PPP3CB', 'PPP3CC', 'ATF4', 'PRKCB', 'PRKACA', 'CREB1', 'CREB3', 'SLC18A1', 'GRIN3A', 'CREB5', 'PRKACG', 'FOSB', 'PRKCA', 'CALM1', 'CAMK2B', 'ADCY5', 'CREB3L2', 'CACNA1D', 'PPP3R2', 'GRIN1', 'CALML3', 'GRIA1', 'GRIN2A', 'DDC', 'SLC6A3', 'MAOB', 'CALM3', 'CAMK2A', 'JUN', 'ATF6B', 'GRIN3B', 'STX1A', 'PPP3R1', 'SIRT1', 'PPP1CA', 'GRIN2D', 'GRIN2C', 'CALM2', 'PPP3CA', 'PRKCG', 'ARC', 'GNAS', 'HDAC1', 'PRKACB', 'GRIA4', 'PPP1CC', 'CALML6', 'CALML5', 'CREB3L3'}, 'Glucagon signaling pathway Homo sapiens hsa04922': {'CAMK2D', 'PHKB', 'PGAM1', 'AKT3', 'CREB3L4', 'CAMK2G', 'PPP3CB', 'PYGM', 'LDHAL6A', 'CALM1', 'PPP3R2', 'PYGB', 'ITPR3', 'ACACB', 'ITPR2', 'PPARGC1A', 'SIRT1', 'PCK1', 'LDHAL6B', 'PRKAG1', 'SLC2A2', 'PRKAA1', 'CALML6', 'CRTC2', 'PRMT1', 'CPT1A', 'CREB3L1', 'GCGR', 'AKT2', 'PPP4C', 'PRKAG3', 'CPT1B', 'G6PC2', 'PPP3CC', 'PRKAA2', 'PLCB1', 'ITPR1', 'CAMK2B', 'G6PC3', 'LDHA', 'CALML3', 'PRKAB1', 'PDHB', 'PGAM4', 'PYGL', 'PLCB4', 'SMEK2', 'SIK1', 'GCG', 'GYS1', 'CALM2', 'GYS2', 'G6PC', 'PLCB2', 'SIK2', 'GCK', 'ADCY2', 'PDHA2', 'LDHC', 'ATF4', 'PDE3B', 'PKM', 'CREB5', 'PHKA2', 'FBP1', 'EP300', 'PPARA', 'PHKA1', 'PDHA1', 'CALM3', 'PCK2', 'PFKL', 'CAMK2A', 'PPP3R1', 'GNAQ', 'SLC2A1', 'PPP3CA', 'CREB1', 'PLCB3', 'ATF2', 'PRKAG2', 'CPT1C', 'PHKG1', 'AKT1', 'PGAM2', 'ACACA', 'PRKACA', 'CREB3', 'PRKACG', 'CREB3L2', 'PRKAB2', 'CREBBP', 'FOXO1', 'PHKG2', 'GNAS', 'PFKFB1', 'PRKACB', 'SMEK1', 'LDHB', 'CALML5', 'CREB3L3'}, 'Adipocytokine signaling pathway Homo sapiens hsa04920': {'LEP', 'ACSL4', 'G6PC', 'TNFRSF1B', 'CPT1A', 'PRKAG2', 'NFKBIB', 'PTPN11', 'CHUK', 'ADIPOQ', 'AKT2', 'CPT1C', 'AKT3', 'PRKAG3', 'IRS4', 'CPT1B', 'TRADD', 'AKT1', 'LEPR', 'G6PC2', 'NFKBIE', 'TRAF2', 'MAPK10', 'NFKB1', 'ACSL3', 'MAPK8', 'RELA', 'CAMKK2', 'PRKAA2', 'ACSL6', 'ACSBG1', 'G6PC3', 'IRS2', 'MTOR', 'ADIPOR2', 'RXRA', 'STAT3', 'NFKBIA', 'CAMKK1', 'NPY', 'JAK2', 'ACSL1', 'SLC2A4', 'PPARA', 'ACACB', 'PRKAB2', 'TNF', 'RXRG', 'STK11', 'PRKAB1', 'PCK2', 'IKBKB', 'ACSBG2', 'IKBKG', 'CD36', 'PPARGC1A', 'ADIPOR1', 'RXRB', 'PRKCQ', 'AGRP', 'SLC2A1', 'MAPK9', 'PCK1', 'IRS1', 'PRKAG1', 'SOCS3', 'TNFRSF1A', 'PRKAA1', 'POMC', 'ACSL5'}, 'Insulin resistance Homo sapiens hsa04931': {'MLXIP', 'NR1H2', 'PIK3R1', 'AKT3', 'CREB3L4', 'PRKCD', 'PYGM', 'PPARGC1B', 'PTEN', 'RELA', 'SLC27A1', 'SLC27A6', 'NR1H3', 'PYGB', 'MTOR', 'STAT3', 'ACACB', 'TNF', 'PTPN1', 'PIK3CD', 'CD36', 'PPARGC1A', 'GSK3B', 'RPS6KB1', 'PPP1CA', 'PCK1', 'PRKAG1', 'SLC2A2', 'PPP1R3D', 'PRKAA1', 'PPP1CC', 'SLC27A3', 'PRKCE', 'MAPK10', 'CRTC2', 'INSR', 'TRIB3', 'RPS6KA6', 'CPT1A', 'PTPN11', 'CREB3L1', 'AKT2', 'SLC27A5', 'PRKAG3', 'RPS6KA1', 'CPT1B', 'G6PC2', 'PRKAA2', 'G6PC3', 'PRKCZ', 'PPP1R3A', 'PIK3CB', 'PRKAB1', 'IKBKB', 'PYGL', 'PDPK1', 'NOS3', 'MLX', 'GYS1', 'PRKCB', 'PPP1R3C', 'GYS2', 'G6PC', 'SLC27A2', 'PIK3CA', 'RPS6KA3', 'NFKB1', 'GFPT1', 'MAPK8', 'SLC27A4', 'PIK3R2', 'CREB5', 'MLXIPL', 'NFKBIA', 'OGT', 'PPP1R3E', 'PPARA', 'INS', 'PCK2', 'PTPRF', 'MAPK9', 'PRKCQ', 'SLC2A1', 'RPS6KA2', 'SLC2A4', 'CREB1', 'PIK3CG', 'PPP1CB', 'PPP2R4', 'PRKAG2', 'PIK3R5', 'AKT1', 'MGEA5', 'PPP1R3B', 'CREB3', 'RPS6KB2', 'IRS2', 'CREB3L2', 'IL6', 'PRKAB2', 'TBC1D4', 'CREB3L3', 'FOXO1', 'SREBF1', 'IRS1', 'SOCS3', 'PIK3R3', 'TNFRSF1A', 'GFPT2'}, 'Insulin signaling pathway Homo sapiens hsa04910': {'PRKAR1B', 'PHKB', 'FBP2', 'PIK3R1', 'RAF1', 'AKT3', 'HKDC1', 'PYGM', 'PRKAR2A', 'ARAF', 'EIF4E', 'CALM1', 'PYGB', 'MTOR', 'ACACB', 'PRKCI', 'SHC4', 'PRKAR1A', 'PTPN1', 'PIK3CD', 'PPARGC1A', 'GSK3B', 'RPS6KB1', 'PPP1CA', 'PCK1', 'PRKAG1', 'BRAF', 'LIPE', 'PPP1R3D', 'PRKAA1', 'PPP1CC', 'CALML6', 'SOS2', 'MAPK10', 'INSR', 'RPS6', 'SOS1', 'HK2', 'HK1', 'RHOQ', 'AKT2', 'PRKAG3', 'PKLR', 'G6PC2', 'PRKAA2', 'GRB2', 'G6PC3', 'CALML3', 'PRKCZ', 'PPP1R3A', 'PIK3CB', 'KRAS', 'PRKAB1', 'IKBKB', 'PYGL', 'PDPK1', 'SOCS1', 'GYS1', 'CALM2', 'PPP1R3C', 'GYS2', 'ELK1', 'CBLC', 'G6PC', 'SH2B2', 'MAPK1', 'MKNK1', 'INPPL1', 'EIF4E2', 'IRS4', 'PIK3CA', 'HK3', 'GCK', 'RAPGEF1', 'CBL', 'PDE3B', 'MAP2K1', 'MAPK8', 'PIK3R2', 'PHKA2', 'FASN', 'FBP1', 'PPP1R3E', 'SOCS2', 'INS', 'PHKA1', 'MAPK3', 'CALM3', 'PCK2', 'RPTOR', 'PTPRF', 'MAPK9', 'INPP5K', 'SOCS4', 'SLC2A4', 'RHEB', 'SHC2', 'PIK3CG', 'PPP1CB', 'SORBS1', 'TRIP10', 'PRKAG2', 'CBLB', 'BAD', 'HRAS', 'PIK3R5', 'SHC3', 'PHKG1', 'SHC1', 'AKT1', 'PRKAR2B', 'ACACA', 'PRKACA', 'PPP1R3F', 'PPP1R3B', 'NRAS', 'EXOC7', 'FLOT1', 'PRKACG', 'RPS6KB2', 'IRS2', 'MAP2K2', 'EIF4E1B', 'EIF4EBP1', 'PRKAB2', 'MKNK2', 'CRKL', 'FOXO1', 'TSC2', 'FLOT2', 'SREBF1', 'TSC1', 'IRS1', 'CRK', 'PHKG2', 'PRKACB', 'PIK3R3', 'SOCS3', 'CALML5'}, 'Type II diabetes mellitus Homo sapiens hsa04930': {'INSR', 'CACNA1A', 'SOCS1', 'MAPK1', 'HK2', 'HK1', 'CACNA1B', 'PIK3R1', 'PDX1', 'ADIPOQ', 'PIK3R5', 'CACNA1C', 'IRS4', 'PIK3CA', 'HK3', 'PKLR', 'GCK', 'PRKCD', 'HKDC1', 'KCNJ11', 'PKM', 'MAPK8', 'PIK3R2', 'PIK3CG', 'IRS2', 'MTOR', 'CACNA1D', 'PRKCZ', 'SLC2A4', 'CACNA1G', 'INS', 'SOCS2', 'PIK3CB', 'TNF', 'MAPK3', 'IKBKB', 'PIK3CD', 'MAPK9', 'IRS1', 'ABCC8', 'SOCS3', 'PIK3R3', 'SLC2A2', 'CACNA1E', 'SOCS4', 'MAFA', 'PRKCE', 'MAPK10'}, 'Longevity regulating pathway - multiple species Homo sapiens hsa04213': {'IGF1R', 'SOD1', 'ADCY9', 'ADCY3', 'INSR', 'ADCY6', 'PRKAG2', 'PIK3R1', 'HRAS', 'PIK3R5', 'HSPA8', 'AKT2', 'CRYAB', 'AKT3', 'PRKAG3', 'IRS4', 'PIK3CA', 'HSPA6', 'ADCY2', 'AKT1', 'ADCY8', 'ATG5', 'PRKACA', 'NRAS', 'CAT', 'HSPA1A', 'PIK3R2', 'HSPA1B', 'PRKAA2', 'HSPA1L', 'RPS6KB2', 'HDAC2', 'PRKACG', 'EIF4EBP2', 'IRS2', 'ADCY5', 'MTOR', 'CLPB', 'HSPA2', 'INS', 'AKT1S1', 'PRKAB2', 'PIK3CB', 'SOD2', 'KRAS', 'PRKAB1', 'RPTOR', 'FOXA2', 'ADCY4', 'ADCY7', 'PIK3CD', 'RPS6KB1', 'SIRT1', 'FOXO1', 'IGF1', 'FOXO3', 'IRS1', 'PRKAG1', 'HDAC1', 'PIK3R3', 'PRKACB', 'PRKAA1', 'ADCY1', 'PIK3CG'}, 'Longevity regulating pathway - mammal Homo sapiens hsa04211': {'IGF1R', 'ADCY9', 'ADCY3', 'ADCY6', 'PIK3R1', 'ADIPOQ', 'AKT3', 'CREB3L4', 'CAT', 'SESN2', 'RELA', 'EIF4E', 'CAMKK1', 'MTOR', 'ADCY7', 'PIK3CD', 'PPARGC1A', 'ADIPOR1', 'RPS6KB1', 'SIRT1', 'PRKAG1', 'PRKAA1', 'INSR', 'ATG13', 'APPL1', 'CREB3L1', 'AKT2', 'PRKAG3', 'ULK1', 'SESN3', 'EHMT2', 'CAMKK2', 'PRKAA2', 'PIK3CB', 'KRAS', 'PRKAB1', 'ADCY4', 'TP53', 'SESN1', 'EIF4E2', 'ULK2', 'IRS4', 'PIK3CA', 'ADCY2', 'ADCY8', 'BAX', 'NFKB1', 'ATF4', 'PIK3R2', 'CREB5', 'ADCY5', 'INS', 'SOD2', 'RB1CC1', 'RPTOR', 'ATG101', 'RHEB', 'ATG5', 'CREB1', 'ADCY1', 'PIK3CG', 'ADIPOR2', 'ATF2', 'CAMK4', 'PRKAG2', 'EHMT1', 'HRAS', 'PIK3R5', 'ULK3', 'AKT1', 'PRKACA', 'NRAS', 'CREB3', 'KL', 'RPS6KB2', 'PRKACG', 'IRS2', 'CREB3L2', 'EIF4E1B', 'EIF4EBP1', 'AKT1S1', 'PRKAB2', 'STK11', 'ATF6B', 'FOXO1', 'TSC2', 'IGF1', 'TSC1', 'FOXO3', 'IRS1', 'PRKACB', 'PIK3R3', 'PPARG', 'CREB3L3'}, 'AMPK signaling pathway Homo sapiens hsa04152': {'IGF1R', 'PPP2R5B', 'FBP2', 'PIK3R1', 'ADIPOQ', 'AKT3', 'CREB3L4', 'LEPR', 'TBC1D1', 'CCNA2', 'CCND1', 'CAMKK1', 'MTOR', 'PPP2R2C', 'RAB2A', 'ACACB', 'HNF4A', 'PFKFB4', 'PIK3CD', 'CD36', 'PPARGC1A', 'STRADA', 'ADIPOR1', 'RPS6KB1', 'SIRT1', 'PFKP', 'PCK1', 'PPP2R1B', 'PRKAG1', 'LIPE', 'PRKAA1', 'LEP', 'CFTR', 'CRTC2', 'INSR', 'RAB8A', 'CPT1A', 'CREB3L1', 'PPP2CB', 'AKT2', 'PPP2CA', 'PRKAG3', 'ULK1', 'CPT1B', 'ELAVL1', 'PFKFB2', 'G6PC2', 'EEF2', 'CCNA1', 'CAMKK2', 'PRKAA2', 'PPP2R2B', 'G6PC3', 'RAB11B', 'PPARG', 'PIK3CB', 'PRKAB1', 'PDPK1', 'MAP3K7', 'PPP2R1A', 'PPP2R3A', 'PPP2R3B', 'GYS1', 'HMGCR', 'RAB14', 'GYS2', 'G6PC', 'IRS4', 'PIK3CA', 'PPP2R5D', 'SCD', 'PIK3R2', 'CREB5', 'FASN', 'FBP1', 'PPP2R5C', 'INS', 'CAB39L', 'RPTOR', 'PCK2', 'PFKL', 'PPP2R5A', 'EEF2K', 'PPP2R2A', 'PFKFB3', 'ADRA1A', 'LOC101930123', 'SLC2A4', 'CAB39', 'RHEB', 'CREB1', 'PIK3CG', 'ADIPOR2', 'PRKAG2', 'PIK3R5', 'CPT1C', 'PPP2R5E', 'MLYCD', 'AKT1', 'ACACA', 'CREB3', 'RPS6KB2', 'RAB10', 'PPP2R3C', 'IRS2', 'CREB3L2', 'STRADB', 'EIF4EBP1', 'AKT1S1', 'PRKAB2', 'PFKM', 'STK11', 'FOXO1', 'TSC2', 'SREBF1', 'TSC1', 'FOXO3', 'IGF1', 'IRS1', 'SCD5', 'PFKFB1', 'PIK3R3', 'PPP2R2D', 'CREB3L3'}, 'mTOR signaling pathway Homo sapiens hsa04150': {'RPS6', 'RPS6KA6', 'MAPK1', 'EIF4E2', 'EIF4B', 'PIK3R1', 'PIK3R5', 'AKT2', 'ULK2', 'RHEB', 'AKT3', 'ULK1', 'RPS6KA1', 'PIK3CA', 'ULK3', 'RPS6KA3', 'AKT1', 'RRAGC', 'PTEN', 'PIK3R2', 'HIF1A', 'PRKAA2', 'EIF4E', 'RPS6KB2', 'PRKCA', 'MTOR', 'RRAGA', 'EIF4E1B', 'RRAGD', 'RRAGB', 'RICTOR', 'EIF4EBP1', 'INS', 'VEGFA', 'AKT1S1', 'PIK3CB', 'TNF', 'CAB39L', 'STK11', 'IKBKB', 'RPTOR', 'MAPK3', 'PDPK1', 'DDIT4', 'PIK3CD', 'STRADA', 'RPS6KB1', 'TSC2', 'IGF1', 'TSC1', 'IRS1', 'MLST8', 'PRKCG', 'RPS6KA2', 'BRAF', 'PIK3R3', 'CAB39', 'PRKAA1', 'PRKCB', 'PIK3CG'}, 'Aldosterone-regulated sodium reabsorption Homo sapiens hsa04960': {'SFN', 'KCNJ1', 'INSR', 'ATP1A3', 'SLC9A3R2', 'SCNN1G', 'MAPK1', 'FXYD2', 'NR3C2', 'ATP1B4', 'ATP1A4', 'PIK3R1', 'PIK3R5', 'ATP1A2', 'PIK3CA', 'SGK1', 'SCNN1A', 'ATP1B1', 'PIK3R2', 'SCNN1B', 'PRKCA', 'HSD11B2', 'INS', 'PIK3CB', 'KRAS', 'ATP1B2', 'MAPK3', 'PDPK1', 'PIK3CD', 'IGF1', 'ATP1B3', 'IRS1', 'PRKCG', 'FXYD4', 'PIK3R3', 'PRKCB', 'NEDD4L', 'PIK3CG', 'ATP1A1'}, 'Carbohydrate digestion and absorption Homo sapiens hsa04973': {'ATP1A3', 'G6PC', 'FXYD2', 'HK2', 'HK1', 'ATP1B4', 'ATP1A4', 'PIK3R1', 'AMY1C', 'PIK3R5', 'ATP1A2', 'AKT2', 'AKT3', 'PLCB2', 'PIK3CA', 'HK3', 'SLC2A5', 'AKT1', 'G6PC2', 'HKDC1', 'LCT', 'ATP1B1', 'PIK3R2', 'AMY2A', 'G6PC3', 'AMY2B', 'CACNA1D', 'SLC37A4', 'AMY1B', 'PIK3CB', 'AMY1A', 'ATP1B2', 'TAS1R3', 'PIK3CD', 'TAS1R2', 'SLC5A1', 'MGAM', 'ATP1B3', 'SI', 'PIK3R3', 'SLC2A2', 'GNAT3', 'PRKCB', 'PIK3CG', 'ATP1A1'}, 'Thyroid hormone signaling pathway Homo sapiens hsa04919': {'MED24', 'NOTCH3', 'RCAN2', 'PIK3R1', 'RAF1', 'AKT3', 'NCOR1', 'MED13', 'ATP1B1', 'PLCG1', 'CCND1', 'MYH6', 'MTOR', 'RXRG', 'NOTCH2', 'NOTCH1', 'PIK3CD', 'GSK3B', 'PFKP', 'ITGAV', 'CTNNB1', 'HDAC1', 'PLCD3', 'FXYD2', 'WNT4', 'PLCD1', 'ATP1A4', 'AKT2', 'ESR1', 'PLCG2', 'PFKFB2', 'NCOA1', 'PLCB1', 'PLN', 'ITGB3', 'RXRA', 'KAT2A', 'PIK3CB', 'CASP9', 'KRAS', 'ATP1B2', 'PDPK1', 'PLCB4', 'TP53', 'MDM2', 'BMP4', 'GATA4', 'SLCO1C1', 'PRKCB', 'MAPK1', 'THRA', 'ATP1A2', 'PLCB2', 'PIK3CA', 'MAP2K1', 'PIK3R2', 'HIF1A', 'HDAC2', 'PLCE1', 'EP300', 'DIO1', 'SRC', 'NOTCH4', 'PLCZ1', 'SLC9A1', 'ATP2A2', 'MED4', 'MAPK3', 'RXRB', 'SLC2A1', 'SIN3A', 'KAT2B', 'STAT1', 'MED16', 'RHEB', 'ACTB', 'PLCB3', 'PIK3CG', 'DIO3', 'ATP1A3', 'MED12L', 'BAD', 'DIO2', 'ATP1B4', 'NCOA2', 'RCAN1', 'MED13L', 'MED27', 'HRAS', 'PIK3R5', 'PLCD4', 'MED30', 'AKT1', 'PRKACA', 'NRAS', 'HDAC3', 'SLC16A2', 'PRKACG', 'PRKCA', 'ACTG1', 'MAP2K2', 'MED12', 'NCOA3', 'MED1', 'MYC', 'SLC16A10', 'CREBBP', 'TBC1D4', 'MED17', 'FOXO1', 'TSC2', 'MED14', 'ATP1B3', 'PRKCG', 'PRKACB', 'PIK3R3', 'THRB', 'ATP1A1'}, 'Sphingolipid signaling pathway Homo sapiens hsa04071': {'MAP3K5', 'PPP2R5B', 'OPRD1', 'SMPD1', 'CERS1', 'PIK3R1', 'RAF1', 'AKT3', 'S1PR5', 'TRAF2', 'CERS6', 'S1PR2', 'PTEN', 'MAPK14', 'RELA', 'GNAI1', 'GAB2', 'ASAH1', 'MAPK11', 'PPP2R2C', 'SPTLC3', 'TNF', 'PLD2', 'PIK3CD', 'SGMS2', 'SPTLC2', 'FCER1A', 'BDKRB2', 'SPTLC1', 'PPP2R1B', 'RAC1', 'PRKCE', 'MAPK10', 'RHOA', 'ACER1', 'DEGS1', 'PPP2CB', 'MS4A2', 'AKT2', 'PPP2CA', 'SMPD2', 'SPHK2', 'FCER1G', 'PLCB1', 'PPP2R2B', 'GNA13', 'ACER2', 'PRKCZ', 'CTSD', 'PIK3CB', 'KRAS', 'PDPK1', 'PPP2R1A', 'PLCB4', 'PPP2R3A', 'NOS3', 'PPP2R3B', 'TP53', 'PRKCB', 'MAPK1', 'PLCB2', 'BID', 'PIK3CA', 'GNAI2', 'MAPK13', 'BAX', 'ADORA3', 'CERS4', 'NFKB1', 'PPP2R5D', 'ABCC1', 'S1PR3', 'MAP2K1', 'MAPK8', 'CERS2', 'PIK3R2', 'DEGS2', 'SGPP1', 'PPP2R5C', 'CERS3', 'MAPK3', 'ADORA1', 'PPP2R5A', 'MAPK9', 'PPP2R2A', 'GNAQ', 'ASAH2', 'PLCB3', 'PIK3CG', 'SGMS1', 'CERS5', 'RAC3', 'NSMAF', 'SGPL1', 'RAC2', 'ROCK2', 'HRAS', 'GNA12', 'PIK3R5', 'PPP2R5E', 'TRADD', 'AKT1', 'BCL2', 'PLD1', 'NRAS', 'ROCK1', 'S1PR1', 'MAPK12', 'PRKCA', 'PPP2R3C', 'SPHK1', 'MAP2K2', 'SGPP2', 'FYN', 'GNAI3', 'PRKCG', 'PPP2R2D', 'PIK3R3', 'TNFRSF1A', 'S1PR4'}, 'Chagas disease (American trypanosomiasis) Homo sapiens hsa05142': {'TLR4', 'IFNG', 'CHUK', 'PIK3R1', 'AKT3', 'GNA11', 'GNA14', 'MAPK14', 'RELA', 'IFNGR2', 'GNAI1', 'MAPK11', 'PPP2R2C', 'CXCL8', 'CD3E', 'TNF', 'CALR', 'C1QB', 'GNAO1', 'FASLG', 'PIK3CD', 'BDKRB2', 'PPP2R1B', 'MAPK10', 'IL12A', 'CASP8', 'CCL5', 'MAP2K4', 'PPP2CB', 'AKT2', 'PPP2CA', 'C1QC', 'IRAK1', 'TGFB2', 'TICAM1', 'CFLAR', 'CCL3L3', 'TGFB1', 'SERPINE1', 'PLCB1', 'PPP2R2B', 'CD247', 'IFNGR1', 'SMAD2', 'CD3G', 'IFNB1', 'PIK3CB', 'IKBKB', 'PPP2R1A', 'FADD', 'PLCB4', 'TLR9', 'NOS2', 'C1QA', 'IL1B', 'MYD88', 'MAPK1', 'PLCB2', 'PIK3CA', 'GNAI2', 'MAPK13', 'NFKB1', 'SMAD3', 'CD3D', 'MAPK8', 'PIK3R2', 'NFKBIA', 'C3', 'MAPK3', 'JUN', 'FAS', 'CCL3L1', 'MAPK9', 'PPP2R2A', 'GNAQ', 'IRAK4', 'IL10', 'ADCY1', 'PLCB3', 'PIK3CG', 'TGFBR1', 'IL12B', 'FOS', 'PIK3R5', 'CCL3', 'TRAF6', 'AKT1', 'TLR6', 'GNA15', 'MAPK12', 'IL2', 'IL6', 'TGFBR2', 'GNAL', 'TLR2', 'TGFB3', 'ACE', 'IKBKG', 'CCL2', 'GNAI3', 'GNAS', 'PPP2R2D', 'PIK3R3', 'TNFRSF1A'}, 'AGE-RAGE signaling pathway in diabetic complications Homo sapiens hsa04933': {'DIAPH1', 'STAT5B', 'AGER', 'PIK3R1', 'FN1', 'AKT3', 'MMP2', 'FIGF', 'PRKCD', 'NFATC1', 'MAPK14', 'RELA', 'PLCG1', 'CCND1', 'MAPK11', 'STAT3', 'CXCL8', 'COL4A2', 'VEGFA', 'TNF', 'NOX1', 'PIK3CD', 'RAC1', 'PLCD3', 'PRKCE', 'MAPK10', 'CDC42', 'PLCD1', 'AKT2', 'PLCG2', 'STAT5A', 'CDKN1B', 'TGFB2', 'CYBB', 'TGFB1', 'SERPINE1', 'PLCB1', 'SMAD2', 'PRKCZ', 'AGTR1', 'PIK3CB', 'COL4A1', 'KRAS', 'PLCB4', 'NOS3', 'IL1A', 'PRKCB', 'COL4A5', 'IL1B', 'NOX3', 'SMAD4', 'MAPK1', 'EGR1', 'PIM1', 'ICAM1', 'PLCB2', 'PIK3CA', 'MAPK13', 'COL1A1', 'BAX', 'SELE', 'NFKB1', 'MAPK8', 'PIK3R2', 'COL3A1', 'PLCE1', 'VEGFC', 'COL4A6', 'VEGFB', 'MAPK3', 'JUN', 'MAPK9', 'STAT1', 'PLCB3', 'PIK3CG', 'TGFBR1', 'EDN1', 'HRAS', 'PIK3R5', 'PLCD4', 'AKT1', 'BCL2', 'CDK4', 'NRAS', 'COL4A3', 'CASP3', 'MAPK12', 'PRKCA', 'JAK2', 'IL6', 'F3', 'TGFBR2', 'TGFB3', 'THBD', 'CCL2', 'COL4A4', 'FOXO1', 'COL1A2', 'PIK3R3', 'SMAD3', 'VCAM1'}, 'Amoebiasis Homo sapiens hsa05146': {'LAMC3', 'MUC2', 'TLR4', 'IFNG', 'VCL', 'PIK3R1', 'FN1', 'C8G', 'GNA11', 'GNA14', 'RELA', 'LAMB2', 'LAMA1', 'COL4A2', 'CXCL8', 'TNF', 'PIK3CD', 'LAMC2', 'LAMA4', 'RAB5A', 'IL12A', 'C9', 'ACTN4', 'LAMA3', 'TGFB2', 'TGFB1', 'PLCB1', 'ACTN2', 'CXCL1', 'PIK3CB', 'COL4A1', 'IL1R1', 'LAMB4', 'PLCB4', 'ARG2', 'PRKCB', 'LAMA5', 'NOS2', 'COL4A5', 'IL1B', 'RAB5C', 'PLCB2', 'PIK3CA', 'COL1A1', 'NFKB1', 'PIK3R2', 'LAMB1', 'SERPINB13', 'COL3A1', 'C8A', 'COL4A6', 'CTSG', 'LAMA2', 'SERPINB3', 'CD14', 'ACTN3', 'C8B', 'GNAQ', 'SERPINB1', 'LAMB3', 'IL10', 'ARG1', 'ADCY1', 'PLCB3', 'PIK3CG', 'LOC102723407', 'IL12B', 'SERPINB10', 'PTK2', 'SERPINB4', 'CD1D', 'PIK3R5', 'ACTN1', 'SERPINB6', 'SERPINB9', 'PRKACA', 'RAB7B', 'GNA15', 'RAB5B', 'PRKACG', 'HSPB1', 'PRKCA', 'CASP3', 'COL4A3', 'IL1R2', 'LAMC1', 'IL6', 'ITGAM', 'GNAL', 'TLR2', 'TGFB3', 'CSF2', 'RAB7A', 'COL4A4', 'COL1A2', 'ITGB2', 'PRKCG', 'GNAS', 'PRKACB', 'PIK3R3'}, 'Natural killer cell mediated cytotoxicity Homo sapiens hsa04650': {'KLRC4-KLRK1', 'IFNG', 'PIK3R1', 'IFNA7', 'RAF1', 'KLRC1', 'FCGR3A', 'PPP3CB', 'NFATC1', 'KIR3DL2', 'IFNA5', 'ARAF', 'PRF1', 'IFNGR2', 'PLCG1', 'PTK2B', 'PPP3R2', 'NCR1', 'IFNA21', 'TNF', 'SHC4', 'FASLG', 'PIK3CD', 'HLA-C', 'KIR2DL2', 'KLRD1', 'BRAF', 'KIR2DL5A', 'RAC1', 'SOS2', 'SOS1', 'IFNA6', 'ICAM2', 'PTPN11', 'PLCG2', 'ULBP3', 'IFNA1', 'IFNA13', 'HLA-B', 'IFNA8', 'PPP3CC', 'NCR2', 'VAV2', 'VAV3', 'FCER1G', 'IFNA2', 'RAET1E', 'IFNA10', 'TNFRSF10D', 'GRB2', 'CD247', 'IFNGR1', 'IFNB1', 'KIR2DS3', 'PIK3CB', 'KRAS', 'IFNA16', 'HLA-G', 'PRKCB', 'CD48', 'ULBP1', 'ULBP2', 'KLRK1', 'LCK', 'MAPK1', 'KLRC3', 'KIR3DL1', 'ICAM1', 'CD244', 'KIR2DS4', 'TNFRSF10B', 'PIK3CA', 'BID', 'SH2D1B', 'MICA', 'SH2D1A', 'SH3BP2', 'RAET1G', 'IFNAR1', 'RAET1L', 'MAP2K1', 'PIK3R2', 'HLA-E', 'NFATC2', 'TNFSF10', 'IFNA4', 'MAPK3', 'VAV1', 'HLA-A', 'FAS', 'PPP3R1', 'LAT', 'KIR2DL4', 'PPP3CA', 'IFNAR2', 'SHC2', 'TNFRSF10C', 'PIK3CG', 'HCST', 'FCGR3B', 'LOC102723407', 'RAC3', 'KLRC2', 'RAC2', 'KIR2DS2', 'GZMB', 'HRAS', 'PIK3R5', 'SHC3', 'SHC1', 'TNFRSF10A', 'SYK', 'NRAS', 'KIR2DS1', 'PTPN6', 'CASP3', 'PRKCA', 'KIR2DL1', 'MAP2K2', 'ITGAL', 'KIR2DL3', 'ZAP70', 'PAK1', 'IFNA14', 'KIR2DS5', 'FYN', 'CSF2', 'TYROBP', 'IFNA17', 'LCP2', 'ITGB2', 'PRKCG', 'NCR3', 'PIK3R3', 'MICB'}, 'Fc gamma R-mediated phagocytosis Homo sapiens hsa04666': {'INPP5D', 'PIK3R1', 'RAF1', 'AKT3', 'FCGR3A', 'PRKCD', 'FCGR2A', 'GAB2', 'PLCG1', 'DOCK2', 'LIMK1', 'PLD2', 'PIK3CD', 'PPAP2B', 'PIP5K1A', 'RPS6KB1', 'RAC1', 'ARPC1A', 'PRKCE', 'MARCKSL1', 'LIMK2', 'PPAP2A', 'CDC42', 'AMPH', 'AKT2', 'CFL1', 'PLCG2', 'VAV2', 'VAV3', 'PIP5K1B', 'WASF3', 'SPHK2', 'PIP5K1C', 'PLA2G4A', 'BIN1', 'PIK3CB', 'PPAP2C', 'GSN', 'PLA2G4E', 'MARCKS', 'MYO10', 'NCF1', 'PRKCB', 'WASF2', 'FCGR1A', 'FCGR2B', 'MAPK1', 'INPPL1', 'ARPC4', 'DNM2', 'PIK3CA', 'ASAP1', 'WAS', 'ASAP2', 'MAP2K1', 'PIK3R2', 'ARPC2', 'PLA2G6', 'MAPK3', 'VAV1', 'LAT', 'ASAP3', 'LYN', 'WASL', 'ARPC3', 'PIK3CG', 'ARF6', 'CFL2', 'LOC102723407', 'PTPRC', 'RAC2', 'PIK3R5', 'PLA2G4D', 'WASF1', 'AKT1', 'VASP', 'SYK', 'ARPC5L', 'ARPC5', 'PLD1', 'PLA2G4B', 'PLA2G4F', 'RPS6KB2', 'HCK', 'PRKCA', 'SPHK1', 'PAK1', 'CRKL', 'SCIN', 'CRK', 'ARPC1B', 'PRKCG', 'PIK3R3'}, 'Choline metabolism in cancer Homo sapiens hsa05231': {'SLC22A1', 'LYPLA1', 'PIK3R1', 'SLC44A5', 'AKT3', 'RAF1', 'PLCG1', 'MTOR', 'DGKA', 'JMJD7-PLA2G4B', 'PLD2', 'PIK3CD', 'PIP5K1A', 'PPAP2B', 'RPS6KB1', 'CHKB', 'RAC1', 'SOS2', 'MAPK10', 'SOS1', 'DGKI', 'PPAP2A', 'DGKG', 'PCYT1B', 'AKT2', 'CHKA', 'SLC44A2', 'PLA2G4C', 'PDGFD', 'PIP5K1B', 'WASF3', 'PIP5K1C', 'RALGDS', 'GRB2', 'SLC22A5', 'DGKZ', 'PLA2G4A', 'SLC22A2', 'PIK3CB', 'KRAS', 'PPAP2C', 'PDPK1', 'SLC22A3', 'DGKE', 'PLA2G4E', 'PRKCB', 'WASF2', 'SLC22A4', 'MAPK1', 'DGKH', 'PIK3CA', 'WAS', 'DGKQ', 'MAP2K1', 'MAPK8', 'PIK3R2', 'HIF1A', 'MAPK3', 'JUN', 'MAPK9', 'RHEB', 'WASL', 'PIK3CG', 'SLC44A4', 'DGKB', 'RAC3', 'FOS', 'RAC2', 'HRAS', 'PIK3R5', 'EGF', 'PLA2G4D', 'EGFR', 'WASF1', 'AKT1', 'DGKD', 'SLC44A3', 'PLD1', 'NRAS', 'PLA2G4B', 'PDGFRB', 'PDGFA', 'PDGFC', 'PLA2G4F', 'PDGFB', 'RPS6KB2', 'PRKCA', 'MAP2K2', 'SLC5A7', 'SP1', 'EIF4EBP1', 'CHPT1', 'GPCPD1', 'DGKK', 'TSC2', 'TSC1', 'PRKCG', 'PIK3R3', 'SLC44A1', 'PCYT1A', 'PDGFRA'}, 'Phospholipase D signaling pathway Homo sapiens hsa04072': {'CXCR2', 'ADCY9', 'ADCY3', 'CYTH4', 'ADCY6', 'LPAR5', 'PIK3R1', 'RAF1', 'AKT3', 'GRM4', 'LPAR6', 'GRM5', 'PLCG1', 'GAB2', 'PTK2B', 'MTOR', 'LPAR1', 'AVPR1B', 'DGKA', 'CXCL8', 'SHC4', 'AVP', 'ADCY7', 'PLD2', 'JMJD7-PLA2G4B', 'PIK3CD', 'PIP5K1A', 'PPAP2B', 'GRM3', 'FCER1A', 'RALB', 'AVPR1A', 'SOS2', 'PTGFR', 'INSR', 'SOS1', 'DGKI', 'PPAP2A', 'RHOA', 'DGKG', 'PTPN11', 'MS4A2', 'AKT2', 'LPAR3', 'PLCG2', 'PLA2G4C', 'PDGFD', 'PIP5K1B', 'FCER1G', 'PIP5K1C', 'CYTH3', 'RALGDS', 'GRB2', 'PLCB1', 'GNA13', 'DGKZ', 'PLA2G4A', 'KIT', 'GRM7', 'AGTR1', 'PIK3CB', 'KRAS', 'PPAP2C', 'ADCY4', 'PLCB4', 'DGKE', 'PLA2G4E', 'GAB1', 'AGPAT1', 'AGPAT3', 'MAPK1', 'CXCR1', 'DGKH', 'PLCB2', 'DNM2', 'PIK3CA', 'ADCY2', 'MRAS', 'ADCY8', 'DGKQ', 'MAP2K1', 'PIK3R2', 'AGPAT5', 'GRM1', 'ADCY5', 'LPAR2', 'RRAS2', 'INS', 'CYTH1', 'MAPK3', 'RALA', 'AVPR2', 'RHEB', 'RAPGEF3', 'SHC2', 'ADCY1', 'PLCB3', 'PIK3CG', 'ARF6', 'LOC102723407', 'DGKB', 'LPAR4', 'HRAS', 'GNA12', 'PIK3R5', 'EGF', 'PLA2G4D', 'SHC3', 'EGFR', 'SHC1', 'AKT1', 'DGKD', 'SYK', 'PLD1', 'NRAS', 'PLA2G4B', 'DNM1', 'GRM6', 'PDGFRB', 'PDGFA', 'PDGFC', 'PLA2G4F', 'PDGFB', 'PRKCA', 'GRM8', 'KITLG', 'SPHK1', 'MAP2K2', 'F2R', 'FYN', 'AGPAT2', 'DNM3', 'DGKK', 'AGPAT4', 'CYTH2', 'TSC2', 'GRM2', 'TSC1', 'RRAS', 'GNAS', 'ARF1', 'RAPGEF4', 'PIK3R3', 'PDGFRA'}, 'Central carbon metabolism in cancer Homo sapiens hsa05230': {'MAPK1', 'HK2', 'HK1', 'SLC16A3', 'PIK3R1', 'HRAS', 'PGAM1', 'PIK3R5', 'SCO2', 'AKT2', 'FGFR1', 'RAF1', 'AKT3', 'MET', 'PIK3CA', 'FLT3', 'HK3', 'GCK', 'EGFR', 'PDHA2', 'GLS', 'AKT1', 'HKDC1', 'PGAM2', 'FGFR2', 'NRAS', 'MAP2K1', 'PKM', 'PTEN', 'PDGFRB', 'SIRT6', 'PIK3R2', 'HIF1A', 'MTOR', 'MAP2K2', 'LDHA', 'G6PD', 'NTRK3', 'KIT', 'MYC', 'PDHA1', 'PIK3CB', 'SLC7A5', 'PFKM', 'C12ORF5', 'SIRT3', 'PFKL', 'PDHB', 'PGAM4', 'KRAS', 'MAPK3', 'PDK1', 'PIK3CD', 'RET', 'IDH1', 'SLC2A1', 'NTRK1', 'PFKP', 'SLC1A5', 'TP53', 'ERBB2', 'FGFR3', 'PIK3R3', 'SLC2A2', 'GLS2', 'PDGFRA', 'PIK3CG'}, 'HIF-1 signaling pathway Homo sapiens hsa04066': {'IGF1R', 'TLR4', 'IFNG', 'CAMK2D', 'PIK3R1', 'AKT3', 'RBX1', 'CAMK2G', 'ANGPT1', 'HKDC1', 'RELA', 'EIF4E', 'IFNGR2', 'PLCG1', 'MTOR', 'STAT3', 'ENO3', 'VEGFA', 'NOX1', 'PIK3CD', 'RPS6KB1', 'EGLN2', 'HMOX1', 'GAPDH', 'ARNT', 'INSR', 'RPS6', 'HK2', 'HK1', 'ENO1', 'AKT2', 'PLCG2', 'VHL', 'CDKN1B', 'CYBB', 'SERPINE1', 'CAMK2B', 'ENO2', 'IFNGR1', 'LDHA', 'PIK3CB', 'PDK1', 'PDHB', 'EPO', 'EGLN1', 'NOS3', 'TFRC', 'PRKCB', 'NOS2', 'CUL2', 'NPPA', 'NOX3', 'TIMP1', 'MAPK1', 'ALDOA', 'MKNK1', 'EIF4E2', 'PGK1', 'PIK3CA', 'HK3', 'PDHA2', 'NFKB1', 'MAP2K1', 'PIK3R2', 'HIF1A', 'IL6R', 'EP300', 'INS', 'PDHA1', 'MAPK3', 'PFKL', 'ANGPT4', 'CAMK2A', 'ANGPT2', 'SLC2A1', 'PFKFB3', 'ERBB2', 'PIK3CG', 'EGLN3', 'EDN1', 'PIK3R5', 'EGF', 'TEK', 'EGFR', 'AKT1', 'BCL2', 'RPS6KB2', 'PRKCA', 'MAP2K2', 'EIF4E1B', 'IL6', 'EIF4EBP1', 'TCEB1', 'CREBBP', 'MKNK2', 'LTBR', 'IGF1', 'PRKCG', 'TCEB2', 'TF', 'PIK3R3', 'FLT1', 'CDKN1A'}, 'Renal cell carcinoma Homo sapiens hsa05211': {'CUL2', 'EGLN3', 'HGF', 'SOS1', 'MAPK1', 'ARNT2', 'CDC42', 'PTPN11', 'TGFA', 'PIK3R1', 'HRAS', 'PIK3R5', 'AKT2', 'RAF1', 'RBX1', 'AKT3', 'PIK3CA', 'MET', 'ETS1', 'RAPGEF1', 'AKT1', 'VHL', 'RAC1', 'TGFB2', 'PAK7', 'NRAS', 'MAP2K1', 'TGFB1', 'PIK3R2', 'EPAS1', 'ARAF', 'GRB2', 'PDGFB', 'HIF1A', 'PAK6', 'MAP2K2', 'PAK2', 'EP300', 'TCEB1', 'VEGFA', 'PAK1', 'PIK3CB', 'PAK4', 'KRAS', 'CREBBP', 'TGFB3', 'MAPK3', 'PAK3', 'JUN', 'PIK3CD', 'RAP1B', 'FH', 'CRKL', 'GAB1', 'EGLN1', 'EGLN2', 'SLC2A1', 'CRK', 'FLCN', 'TCEB2', 'BRAF', 'PIK3R3', 'RAP1A', 'ARNT', 'SOS2', 'PIK3CG'}, 'ErbB signaling pathway Homo sapiens hsa04012': {'CAMK2D', 'STAT5B', 'PIK3R1', 'EREG', 'RAF1', 'AKT3', 'ABL2', 'CAMK2G', 'ARAF', 'PLCG1', 'MTOR', 'NCK1', 'SHC4', 'PIK3CD', 'GSK3B', 'RPS6KB1', 'HBEGF', 'BRAF', 'SOS2', 'MAPK10', 'SOS1', 'TGFA', 'MAP2K4', 'ERBB4', 'AKT2', 'NRG2', 'PLCG2', 'STAT5A', 'CDKN1B', 'GRB2', 'CAMK2B', 'PAK6', 'MAP2K7', 'PIK3CB', 'KRAS', 'GAB1', 'NRG4', 'PRKCB', 'ELK1', 'CBLC', 'MAPK1', 'PIK3CA', 'NRG1', 'CBL', 'MAP2K1', 'MAPK8', 'PIK3R2', 'ERBB3', 'NRG3', 'PAK2', 'NCK2', 'SRC', 'MAPK3', 'CAMK2A', 'JUN', 'MAPK9', 'BTC', 'ERBB2', 'SHC2', 'PIK3CG', 'CBLB', 'BAD', 'PTK2', 'HRAS', 'PIK3R5', 'EGF', 'SHC3', 'EGFR', 'SHC1', 'AKT1', 'PAK7', 'NRAS', 'ABL1', 'RPS6KB2', 'PRKCA', 'MAP2K2', 'MYC', 'EIF4EBP1', 'PAK4', 'PAK1', 'AREG', 'PAK3', 'CRKL', 'CRK', 'PRKCG', 'PIK3R3', 'CDKN1A'}, 'Acute myeloid leukemia Homo sapiens hsa05221': {'RUNX1T1', 'TCF7', 'SOS1', 'TCF7L1', 'SPI1', 'MAPK1', 'STAT5B', 'BAD', 'CHUK', 'PIK3R1', 'PIM1', 'HRAS', 'PIK3R5', 'AKT2', 'RAF1', 'AKT3', 'FLT3', 'PIK3CA', 'LEF1', 'AKT1', 'TCF7L2', 'STAT5A', 'NFKB1', 'RUNX1', 'NRAS', 'MAP2K1', 'CCNA1', 'PIK3R2', 'RELA', 'ARAF', 'JUP', 'RPS6KB2', 'GRB2', 'CCND1', 'MTOR', 'STAT3', 'MAP2K2', 'KIT', 'RARA', 'MYC', 'EIF4EBP1', 'PIM2', 'PIK3CB', 'CEBPA', 'KRAS', 'IKBKB', 'MAPK3', 'IKBKG', 'PIK3CD', 'RPS6KB1', 'ZBTB16', 'PPARD', 'PML', 'BRAF', 'PIK3R3', 'SOS2', 'PIK3CG'}, 'Endometrial cancer Homo sapiens hsa05213': {'TCF7', 'SOS1', 'TCF7L1', 'ELK1', 'MAPK1', 'CTNNA2', 'BAD', 'PIK3R1', 'HRAS', 'PIK3R5', 'EGF', 'AKT2', 'RAF1', 'AKT3', 'PIK3CA', 'LEF1', 'EGFR', 'AKT1', 'TCF7L2', 'NRAS', 'MAP2K1', 'PTEN', 'AXIN1', 'CTNNA3', 'PIK3R2', 'ARAF', 'GRB2', 'AXIN2', 'MLH1', 'CCND1', 'CTNNA1', 'MAP2K2', 'CDH1', 'MYC', 'CASP9', 'PIK3CB', 'KRAS', 'MAPK3', 'PDPK1', 'ILK', 'PIK3CD', 'GSK3B', 'FOXO3', 'APC2', 'TP53', 'BRAF', 'ERBB2', 'APC', 'PIK3R3', 'CTNNB1', 'SOS2', 'PIK3CG'}, 'Colorectal cancer Homo sapiens hsa05210': {'TCF7', 'SMAD4', 'TCF7L1', 'DCC', 'TGFBR1', 'RHOA', 'MAPK1', 'APPL1', 'BAD', 'FOS', 'RAC3', 'RAC2', 'PIK3R1', 'PIK3R5', 'AKT2', 'RAF1', 'MSH2', 'AKT3', 'PIK3CA', 'LEF1', 'MSH6', 'AKT1', 'TCF7L2', 'BCL2', 'BAX', 'TGFB2', 'BIRC5', 'MAP2K1', 'MAPK8', 'AXIN1', 'TGFB1', 'CYCS', 'PIK3R2', 'ARAF', 'RALGDS', 'AXIN2', 'CASP3', 'MLH1', 'CCND1', 'SMAD2', 'MYC', 'TGFBR2', 'CASP9', 'PIK3CB', 'KRAS', 'MAPK3', 'TGFB3', 'JUN', 'PIK3CD', 'GSK3B', 'MSH3', 'MAPK9', 'APC2', 'TP53', 'BRAF', 'CTNNB1', 'APC', 'PIK3R3', 'SMAD3', 'RAC1', 'PIK3CG', 'MAPK10'}, 'Pancreatic cancer Homo sapiens hsa05212': {'SMAD4', 'TGFBR1', 'MAPK1', 'RALBP1', 'CDC42', 'BAD', 'RAC3', 'TGFA', 'CHUK', 'RAC2', 'PIK3R1', 'PIK3R5', 'EGF', 'AKT2', 'ARHGEF6', 'RAF1', 'AKT3', 'PIK3CA', 'EGFR', 'AKT1', 'CDKN2A', 'TGFB2', 'NFKB1', 'RAC1', 'CDK4', 'PLD1', 'CDK6', 'MAP2K1', 'MAPK8', 'TGFB1', 'RELA', 'PIK3R2', 'E2F3', 'ARAF', 'RALGDS', 'CCND1', 'SMAD2', 'STAT3', 'BRCA2', 'TGFBR2', 'VEGFA', 'CASP9', 'PIK3CB', 'RB1', 'KRAS', 'TGFB3', 'IKBKB', 'MAPK3', 'E2F2', 'IKBKG', 'PIK3CD', 'RALA', 'MAPK9', 'E2F1', 'RALB', 'TP53', 'BRAF', 'ERBB2', 'STAT1', 'PIK3R3', 'SMAD3', 'BCL2L1', 'JAK1', 'RAD51', 'PIK3CG', 'MAPK10'}, 'Chronic myeloid leukemia Homo sapiens hsa05220': {'SOS1', 'SMAD4', 'CBLC', 'TGFBR1', 'MAPK1', 'STAT5B', 'MECOM', 'CBLB', 'BAD', 'PTPN11', 'CHUK', 'PIK3R1', 'HRAS', 'PIK3R5', 'AKT2', 'RAF1', 'AKT3', 'SHC3', 'PIK3CA', 'SHC1', 'AKT1', 'BCR', 'STAT5A', 'CDKN1B', 'CDKN2A', 'TGFB2', 'NFKB1', 'CBL', 'RUNX1', 'CDK4', 'CDK6', 'NRAS', 'MAP2K1', 'ABL1', 'TGFB1', 'RELA', 'PIK3R2', 'E2F3', 'ARAF', 'GRB2', 'HDAC2', 'GAB2', 'CCND1', 'NFKBIA', 'MAP2K2', 'CTBP2', 'CTBP1', 'MYC', 'TGFBR2', 'PIK3CB', 'RB1', 'KRAS', 'TGFB3', 'SHC4', 'IKBKB', 'E2F2', 'MAPK3', 'IKBKG', 'PIK3CD', 'CRKL', 'E2F1', 'CRK', 'TP53', 'BRAF', 'MDM2', 'HDAC1', 'PIK3R3', 'SMAD3', 'BCL2L1', 'SHC2', 'SOS2', 'PIK3CG', 'CDKN1A'}, 'Prostate cancer Homo sapiens hsa05215': {'IGF1R', 'TCF7', 'TCF7L1', 'CHUK', 'PIK3R1', 'FGFR1', 'RAF1', 'AKT3', 'CREB3L4', 'LEF1', 'PTEN', 'RELA', 'ARAF', 'CCND1', 'MTOR', 'CDK2', 'HSP90AB1', 'PIK3CD', 'GSK3B', 'BRAF', 'CTNNB1', 'SOS2', 'SOS1', 'TGFA', 'CREB3L1', 'AKT2', 'HSP90B1', 'TCF7L2', 'CDKN1B', 'PDGFD', 'FGFR2', 'E2F3', 'GRB2', 'KLK3', 'CASP9', 'PIK3CB', 'KRAS', 'IKBKB', 'PDPK1', 'E2F2', 'CCNE1', 'HSP90AA1', 'TP53', 'MDM2', 'MAPK1', 'PIK3CA', 'NFKB1', 'ATF4', 'MAP2K1', 'PIK3R2', 'CREB5', 'NFKBIA', 'EP300', 'INS', 'RB1', 'MAPK3', 'NKX3-1', 'INSRR', 'ERBB2', 'CREB1', 'PIK3CG', 'BAD', 'HRAS', 'PIK3R5', 'EGF', 'EGFR', 'AKT1', 'BCL2', 'NRAS', 'CREB3', 'PDGFRB', 'PDGFA', 'PDGFC', 'PDGFB', 'SRD5A2', 'CREB3L2', 'MAP2K2', 'CREBBP', 'CREB3L3', 'IKBKG', 'GSTP1', 'FOXO1', 'E2F1', 'IGF1', 'AR', 'CCNE2', 'PIK3R3', 'PDGFRA', 'CDKN1A'}, 'Melanoma Homo sapiens hsa05218': {'IGF1R', 'HGF', 'FGF14', 'MITF', 'FGF22', 'MAPK1', 'FGF23', 'FGF10', 'BAD', 'FGF8', 'PIK3R1', 'HRAS', 'PIK3R5', 'EGF', 'AKT2', 'FGFR1', 'RAF1', 'AKT3', 'MET', 'PIK3CA', 'FGF1', 'EGFR', 'AKT1', 'CDKN2A', 'PDGFD', 'FGF6', 'CDK4', 'CDK6', 'NRAS', 'MAP2K1', 'FGF17', 'PTEN', 'FGF4', 'PIK3R2', 'PDGFRB', 'E2F3', 'ARAF', 'PDGFC', 'PDGFB', 'PDGFA', 'CCND1', 'MAP2K2', 'FGF16', 'FGF5', 'FGF7', 'CDH1', 'FGF9', 'FGF3', 'PIK3CB', 'RB1', 'KRAS', 'FGF2', 'MAPK3', 'FGF21', 'E2F2', 'FGF18', 'PIK3CD', 'FGF20', 'E2F1', 'IGF1', 'FGF13', 'TP53', 'BRAF', 'MDM2', 'PIK3R3', 'FGF11', 'FGF12', 'FGF19', 'PDGFRA', 'PIK3CG', 'CDKN1A'}, 'Glioma Homo sapiens hsa05214': {'IGF1R', 'SOS1', 'CAMK2D', 'MAPK1', 'TGFA', 'PIK3R1', 'HRAS', 'PIK3R5', 'EGF', 'AKT2', 'RAF1', 'AKT3', 'SHC3', 'PIK3CA', 'PLCG2', 'EGFR', 'SHC1', 'AKT1', 'CAMK2G', 'CDKN2A', 'PRKCB', 'CDK4', 'CDK6', 'NRAS', 'MAP2K1', 'PTEN', 'PDGFRB', 'PIK3R2', 'E2F3', 'ARAF', 'GRB2', 'PDGFB', 'PDGFA', 'PRKCA', 'CALM1', 'CCND1', 'CAMK2B', 'MTOR', 'PIK3CG', 'PLCG1', 'MAP2K2', 'CALML3', 'PIK3CB', 'RB1', 'CALM3', 'SHC4', 'KRAS', 'CAMK2A', 'E2F2', 'MAPK3', 'PIK3CD', 'SHC2', 'E2F1', 'PDGFRA', 'IGF1', 'CALM2', 'PRKCG', 'TP53', 'BRAF', 'MDM2', 'PIK3R3', 'CALML6', 'SOS2', 'CALML5', 'CDKN1A'}, 'Non-small cell lung cancer Homo sapiens hsa05223': {'SOS1', 'MAPK1', 'BAD', 'TGFA', 'PIK3R1', 'HRAS', 'PIK3R5', 'EGF', 'AKT2', 'RAF1', 'AKT3', 'PLCG2', 'PIK3CA', 'EGFR', 'AKT1', 'CDKN2A', 'CDK4', 'CDK6', 'NRAS', 'MAP2K1', 'PIK3R2', 'E2F3', 'ARAF', 'GRB2', 'PRKCA', 'CCND1', 'PLCG1', 'RXRA', 'STK4', 'MAP2K2', 'ALK', 'RASSF1', 'RASSF5', 'CASP9', 'PIK3CB', 'RXRG', 'RB1', 'KRAS', 'MAPK3', 'PDPK1', 'E2F2', 'PIK3CD', 'RXRB', 'FHIT', 'E2F1', 'FOXO3', 'RARB', 'TP53', 'PRKCG', 'BRAF', 'ERBB2', 'PIK3R3', 'EML4', 'PRKCB', 'SOS2', 'PIK3CG'}, 'VEGF signaling pathway Homo sapiens hsa04370': {'SH2D2A', 'MAPK1', 'MAPKAPK2', 'BAD', 'CDC42', 'RAC3', 'RAC2', 'PTK2', 'PIK3R1', 'MAPKAPK3', 'HRAS', 'PIK3R5', 'AKT2', 'PLA2G4D', 'RAF1', 'AKT3', 'PLCG2', 'PIK3CA', 'AKT1', 'MAPK13', 'PPP3CB', 'PPP3CC', 'PLA2G4C', 'PRKCB', 'NRAS', 'SPHK2', 'MAPK14', 'MAP2K1', 'PLA2G4B', 'PIK3R2', 'PLA2G4F', 'HSPB1', 'MAPK12', 'PRKCA', 'PPP3R2', 'SPHK1', 'PLCG1', 'PLA2G4A', 'NFATC2', 'MAPK11', 'MAP2K2', 'SRC', 'VEGFA', 'CASP9', 'PIK3CB', 'KDR', 'PTGS2', 'KRAS', 'MAPK3', 'JMJD7-PLA2G4B', 'PIK3CD', 'PPP3R1', 'PLA2G4E', 'PXN', 'NOS3', 'PRKCG', 'PPP3CA', 'PIK3R3', 'RAC1', 'SHC2', 'PIK3CG'}, 'Fc epsilon RI signaling pathway Homo sapiens hsa04664': {'SOS1', 'IL13', 'LOC102723407', 'INPP5D', 'MAPK1', 'RAC3', 'MAP2K4', 'RAC2', 'IL4', 'MS4A2', 'PIK3R1', 'HRAS', 'PIK3R5', 'AKT2', 'PLA2G4D', 'RAF1', 'AKT3', 'PLCG2', 'PIK3CA', 'AKT1', 'MAPK13', 'PLA2G4C', 'SYK', 'VAV2', 'VAV3', 'NRAS', 'FCER1G', 'MAPK14', 'MAP2K1', 'PLA2G4B', 'MAP2K3', 'PIK3R2', 'MAPK8', 'PLA2G4F', 'GRB2', 'GAB2', 'MAPK12', 'PRKCA', 'PLCG1', 'PLA2G4A', 'MAPK11', 'MAP2K2', 'MAP2K7', 'PIK3CB', 'TNF', 'FYN', 'KRAS', 'MAPK3', 'VAV1', 'PDPK1', 'JMJD7-PLA2G4B', 'CSF2', 'BTK', 'PIK3CD', 'IL5', 'MAPK9', 'LCP2', 'PLA2G4E', 'FCER1A', 'LAT', 'IL3', 'MAP2K6', 'PIK3R3', 'LYN', 'RAC1', 'SOS2', 'PIK3CG', 'MAPK10'}, 'B cell receptor signaling pathway Homo sapiens hsa04662': {'FCGR2B', 'IFITM1', 'SOS1', 'LOC102723407', 'RASGRP3', 'INPP5D', 'MAPK1', 'INPPL1', 'NFKBIB', 'FOS', 'RAC3', 'CHUK', 'RAC2', 'PIK3R1', 'CD19', 'HRAS', 'PIK3R5', 'CD22', 'AKT2', 'BCL10', 'RAF1', 'AKT3', 'PLCG2', 'PIK3CA', 'LILRB3', 'RAC1', 'AKT1', 'PPP3CB', 'PPP3CC', 'NFKBIE', 'SYK', 'NFATC1', 'VAV2', 'VAV3', 'CR2', 'NFKB1', 'PIK3AP1', 'NRAS', 'MAP2K1', 'RELA', 'PIK3R2', 'PTPN6', 'GRB2', 'PPP3R2', 'CD79A', 'NFATC2', 'NFKBIA', 'MAP2K2', 'DAPP1', 'PIK3CB', 'KRAS', 'IKBKB', 'BLNK', 'VAV1', 'MALT1', 'NFATC3', 'JUN', 'BTK', 'PIK3CD', 'MAPK3', 'CD81', 'GSK3B', 'PPP3R1', 'IKBKG', 'CD79B', 'CARD11', 'PPP3CA', 'PIK3R3', 'LYN', 'CD72', 'PRKCB', 'SOS2', 'PIK3CG'}, 'T cell receptor signaling pathway Homo sapiens hsa04660': {'IFNG', 'CHUK', 'PIK3R1', 'RAF1', 'AKT3', 'PPP3CB', 'NFATC1', 'MAPK14', 'MAP3K14', 'RELA', 'PLCG1', 'PPP3R2', 'MAPK11', 'NCK1', 'CD3E', 'ITK', 'ICOS', 'TNF', 'CD8B', 'PIK3CD', 'GSK3B', 'DLG1', 'SOS2', 'SOS1', 'RHOA', 'CDC42', 'NFKBIB', 'AKT2', 'PPP3CC', 'NFKBIE', 'VAV2', 'VAV3', 'GRB2', 'CD247', 'PAK6', 'MAP2K7', 'CD3G', 'PIK3CB', 'KRAS', 'IKBKB', 'PDPK1', 'MAP3K7', 'TEC', 'GRAP2', 'CD4', 'CBLC', 'LCK', 'MAPK1', 'PIK3CA', 'MAPK13', 'NFKB1', 'CBL', 'MAP2K1', 'CD3D', 'PIK3R2', 'NFATC2', 'NFKBIA', 'PAK2', 'NCK2', 'MAPK3', 'VAV1', 'MALT1', 'JUN', 'CD28', 'PPP3R1', 'MAPK9', 'PRKCQ', 'LAT', 'PPP3CA', 'IL10', 'RASGRP1', 'PIK3CG', 'PDCD1', 'PTPRC', 'CBLB', 'FOS', 'IL4', 'HRAS', 'PIK3R5', 'BCL10', 'MAP3K8', 'AKT1', 'PAK7', 'CDK4', 'NRAS', 'PTPN6', 'MAPK12', 'IL2', 'MAP2K2', 'ZAP70', 'PAK4', 'PAK1', 'FYN', 'PAK3', 'CSF2', 'CD8A', 'NFATC3', 'IKBKG', 'IL5', 'CD40LG', 'LCP2', 'CARD11', 'CTLA4', 'PIK3R3'}, 'Neurotrophin signaling pathway Homo sapiens hsa04722': {'MAP3K5', 'CAMK2D', 'PIK3R1', 'TP73', 'NTF3', 'RAF1', 'AKT3', 'ARHGDIA', 'SH2B3', 'CAMK2G', 'PRKCD', 'IRAK3', 'MAPK14', 'RELA', 'PLCG1', 'CALM1', 'MAPK11', 'NTRK3', 'SH2B1', 'SORT1', 'SHC4', 'FASLG', 'ZNF274', 'PIK3CD', 'GSK3B', 'NTRK1', 'BRAF', 'RAP1A', 'RAC1', 'CALML6', 'SOS2', 'MAPK10', 'SOS1', 'NGFR', 'FRS2', 'RHOA', 'RPS6KA6', 'MAPKAPK2', 'NFKBIB', 'PTPN11', 'CDC42', 'ARHGDIB', 'AKT2', 'PLCG2', 'RPS6KA1', 'IRAK2', 'IRAK1', 'NFKBIE', 'MAP3K1', 'YWHAE', 'GRB2', 'CAMK2B', 'CALML3', 'MAP2K7', 'PIK3CB', 'KRAS', 'IKBKB', 'NTRK2', 'PDPK1', 'RAP1B', 'GAB1', 'TP53', 'CALM2', 'BDNF', 'SH2B2', 'MAPK1', 'MATK', 'PIK3CA', 'RPS6KA3', 'RAPGEF1', 'MAPK13', 'BAX', 'NFKB1', 'ATF4', 'MAP2K1', 'MAPK8', 'PIK3R2', 'NGFRAP1', 'KIDINS220', 'NFKBIA', 'PRDM4', 'RPS6KA5', 'MAPK3', 'CALM3', 'CAMK2A', 'JUN', 'MAPK9', 'MAGED1', 'RPS6KA2', 'NTF4', 'IRAK4', 'NGF', 'SHC2', 'PIK3CG', 'PSEN1', 'CAMK4', 'BAD', 'HRAS', 'PIK3R5', 'SHC3', 'TRAF6', 'SHC1', 'AKT1', 'BCL2', 'MAP3K3', 'NRAS', 'ABL1', 'ARHGDIG', 'MAPK12', 'MAP2K2', 'RIPK2', 'MAP2K5', 'PSEN2', 'MAPK7', 'CRKL', 'IRS1', 'FOXO3', 'CRK', 'PIK3R3', 'CALML5'}, 'Prolactin signaling pathway Homo sapiens hsa04917': {'ELF5', 'CISH', 'TNFSF11', 'SOS1', 'MAPK1', 'STAT5B', 'FOS', 'LHB', 'GALT', 'PIK3R1', 'HRAS', 'PIK3R5', 'AKT2', 'RAF1', 'TH', 'SHC3', 'PIK3CA', 'TNFRSF11A', 'AKT3', 'GCK', 'SHC1', 'PRL', 'MAPK13', 'AKT1', 'CYP17A1', 'CGA', 'STAT5A', 'NFKB1', 'NRAS', 'MAP2K1', 'MAPK14', 'ESR2', 'MAPK8', 'RELA', 'PIK3R2', 'GRB2', 'MAPK12', 'CCND1', 'SLC2A2', 'MAPK11', 'MAP2K2', 'STAT3', 'JAK2', 'SOCS2', 'IRF1', 'SRC', 'SOCS6', 'INS', 'PIK3CB', 'KRAS', 'MAPK3', 'PRLR', 'SHC4', 'CSN2', 'LHCGR', 'ESR1', 'CCND2', 'PIK3CD', 'GSK3B', 'SOCS5', 'MAPK9', 'FOXO3', 'SOCS3', 'PIK3R3', 'SOCS4', 'STAT1', 'SOCS1', 'SOCS7', 'SHC2', 'SOS2', 'PIK3CG', 'MAPK10'}, 'FoxO signaling pathway Homo sapiens hsa04068': {'IGF1R', 'BNIP3', 'CHUK', 'PIK3R1', 'RAF1', 'AKT3', 'GABARAPL1', 'FOXO4', 'RBL2', 'BCL6', 'SKP2', 'CAT', 'PTEN', 'MAPK14', 'PLK3', 'CDKN2B', 'FOXO6', 'ARAF', 'BCL2L11', 'CCND1', 'MAPK11', 'STK4', 'GADD45A', 'STAT3', 'CDK2', 'GADD45G', 'CDKN1A', 'FASLG', 'CCND2', 'PIK3CD', 'SIRT1', 'PCK1', 'PRKAG1', 'FOXG1', 'BRAF', 'PRKAA1', 'SOS2', 'MAPK10', 'INSR', 'SOS1', 'PRMT1', 'SETD7', 'FBXO25', 'AKT2', 'PLK4', 'CSNK1E', 'PRKAG3', 'G6PC2', 'CDKN1B', 'TGFB2', 'TGFB1', 'HOMER3', 'GRB2', 'PRKAA2', 'HOMER2', 'G6PC3', 'SMAD2', 'NLK', 'PIK3CB', 'KRAS', 'PRKAB1', 'IKBKB', 'PLK2', 'PDPK1', 'MDM2', 'SGK3', 'USP7', 'SMAD4', 'G6PC', 'MAPK1', 'C8ORF44-SGK3', 'CCNG2', 'IRS4', 'PIK3CA', 'MAPK13', 'RAG1', 'MAP2K1', 'MAPK8', 'PIK3R2', 'CCNB3', 'ATG12', 'GRM1', 'TNFSF10', 'EP300', 'GABARAP', 'INS', 'SOD2', 'MAPK3', 'PCK2', 'MAPK9', 'SGK2', 'RAG2', 'SLC2A4', 'IL10', 'PIK3CG', 'TGFBR1', 'PRKAG2', 'HRAS', 'PIK3R5', 'EGF', 'KLF2', 'EGFR', 'SGK1', 'AKT1', 'PLK1', 'AGAP2', 'CCNB2', 'NRAS', 'ATM', 'GABARAPL2', 'S1PR1', 'MAPK12', 'GADD45B', 'IRS2', 'IL7R', 'HOMER1', 'MAP2K2', 'IL6', 'FBXO32', 'TGFBR2', 'PRKAB2', 'STK11', 'CREBBP', 'TGFB3', 'FOXO1', 'IGF1', 'FOXO3', 'IRS1', 'CDKN2D', 'PIK3R3', 'SMAD3', 'S1PR4', 'CCNB1'}, 'MAPK signaling pathway Homo sapiens hsa04010': {'MAP3K5', 'PTPN7', 'CACNA1I', 'PPP5C', 'FLNC', 'FGF10', 'CHUK', 'CACNG8', 'FGF8', 'RPS6KA4', 'MAPKAPK3', 'NTF3', 'FGFR1', 'AKT3', 'RAF1', 'NR4A1', 'CACNA2D3', 'CACNG6', 'PPP3CB', 'TRAF2', 'NFATC1', 'MAPKAPK5', 'CACNA2D4', 'ECSIT', 'FGF17', 'CACNB4', 'MAPK14', 'MAP3K14', 'CACNA1S', 'STK3', 'RELA', 'CACNG1', 'CACNA2D1', 'PPP3R2', 'CACNA1D', 'MAPK11', 'STK4', 'GADD45A', 'HSPA2', 'MEF2C', 'CACNB3', 'GADD45G', 'DDIT3', 'TNF', 'FGF2', 'FGF21', 'DUSP4', 'JMJD7-PLA2G4B', 'FGF18', 'FASLG', 'FGF20', 'RASGRP4', 'NTRK1', 'STMN1', 'MAP2K6', 'BRAF', 'TAB1', 'CACNG4', 'RAP1A', 'DUSP9', 'RAC1', 'PPP5D1', 'FGF19', 'MAP3K2', 'CACNA1E', 'SOS2', 'MAPK10', 'RASA2', 'CACNG7', 'CACNA2D2', 'RASA1', 'CACNA1A', 'SOS1', 'DUSP16', 'CACNG3', 'FGF22', 'RASGRP3', 'RPS6KA6', 'GNG12', 'MAPKAPK2', 'CDC42', 'MAP2K4', 'CACNA1B', 'AKT2', 'CACNG5', 'RPS6KA1', 'CACNG2', 'PLA2G4C', 'PPP3CC', 'TGFB2', 'MAP4K2', 'FGFR2', 'DUSP10', 'MAP3K1', 'RAPGEF2', 'ELK4', 'DUSP2', 'HSPA1A', 'TGFB1', 'HSPA1B', 'LAMTOR3', 'GRB2', 'FGF4', 'NLK', 'MAPK8IP3', 'PLA2G4A', 'FGF16', 'MAP2K7', 'TAB2', 'CACNA1G', 'FGF3', 'RASGRP2', 'KRAS', 'IKBKB', 'NTRK2', 'MAP3K7', 'DUSP8', 'IL1R1', 'RAP1B', 'CACNB1', 'PLA2G4E', 'FLNB', 'DUSP3', 'IL1A', 'TP53', 'MAP4K1', 'CDC25B', 'FGF12', 'PRKCB', 'FGF13', 'BDNF', 'IL1B', 'MAPT', 'ELK1', 'TAOK1', 'RELB', 'MOS', 'MECOM', 'MKNK1', 'MAPK1', 'DUSP6', 'DUSP5', 'CACNA1C', 'HSPA8', 'MAP3K6', 'DUSP1', 'HSPA6', 'MRAS', 'RASGRF1', 'MAPK13', 'RPS6KA3', 'MAPK8IP1', 'MAP3K12', 'NFKB1', 'ATF4', 'MAP2K1', 'MAP3K11', 'MAPK8', 'JUND', 'MAP3K4', 'MAP2K3', 'MAX', 'FGF5', 'PPM1B', 'MAP3K13', 'PAK2', 'RRAS2', 'FGF9', 'RPS6KA5', 'MAPK3', 'ARRB2', 'CD14', 'JUN', 'FGFR4', 'DUSP7', 'FAS', 'PPP3R1', 'MAPK9', 'RPS6KA2', 'NTF4', 'PPP3CA', 'FGF11', 'NGF', 'ZAK', 'NF1', 'RASGRP1', 'ATF2', 'FGF14', 'PPM1A', 'CACNA1F', 'TGFBR1', 'PTPN5', 'FGF23', 'CACNB2', 'RAC3', 'FOS', 'RAC2', 'HRAS', 'GNA12', 'EGF', 'PLA2G4D', 'FGF1', 'MAP3K8', 'TRAF6', 'EGFR', 'AKT1', 'TAOK2', 'MAP4K4', 'MAP3K3', 'PRKACA', 'FGF6', 'SRF', 'PLA2G4B', 'NRAS', 'ARRB1', 'PDGFA', 'PDGFRB', 'PLA2G4F', 'HSPA1L', 'PDGFB', 'PRKACG', 'MAPK12', 'GADD45B', 'PRKCA', 'HSPB1', 'CASP3', 'IL1R2', 'MAP2K2', 'NFKB2', 'FGF7', 'RASGRF2', 'MYC', 'TGFBR2', 'PAK1', 'CACNA1H', 'MAPK8IP2', 'TGFB3', 'NFATC3', 'IKBKG', 'MAP2K5', 'MKNK2', 'MAPK7', 'CRKL', 'DAXX', 'CRK', 'TAOK3', 'RRAS', 'PRKCG', 'FLNA', 'FGFR3', 'PRKACB', 'TNFRSF1A', 'PTPRR', 'PDGFRA', 'MAP4K3'}, 'Ras signaling pathway Homo sapiens hsa04014': {'IGF1R', 'PLA1A', 'FLT4', 'KSR2', 'FGF10', 'TIAM1', 'ETS2', 'CHUK', 'GNB3', 'FGF8', 'PIK3R1', 'GNGT2', 'RASAL1', 'GRIN2B', 'FGFR1', 'AKT3', 'RAF1', 'GNB5', 'ABL2', 'PLA2G16', 'FIGF', 'BRAP', 'ANGPT1', 'RASAL3', 'FOXO4', 'RGL2', 'PLA2G2D', 'FGF17', 'GNG5', 'RELA', 'CSF1', 'PLCG1', 'CALM1', 'GAB2', 'GRIN1', 'STK4', 'SHOC2', 'VEGFA', 'PLA2G12B', 'RIN1', 'FGF2', 'SHC4', 'FGF21', 'JMJD7-PLA2G4B', 'PLA2G3', 'FGF18', 'FASLG', 'RASA4', 'PLD2', 'FGF20', 'RASGRP4', 'PIK3CD', 'RALB', 'TBK1', 'RAP1A', 'RAC1', 'CALML6', 'FGF19', 'SOS2', 'PGF', 'MAPK10', 'RASA2', 'PLA2G5', 'RAB5A', 'RASA1', 'INSR', 'SOS1', 'GNG3', 'NGFR', 'FGF22', 'RHOA', 'GNG12', 'RASGRP3', 'GNB2', 'CDC42', 'PTPN11', 'AKT2', 'PLCG2', 'ETS1', 'HTR7', 'EFNA4', 'PLA2G2A', 'PLA2G2E', 'PLA2G12A', 'PLA2G4C', 'PDGFD', 'EFNA5', 'FGFR2', 'FGF4', 'EPHA2', 'RALGDS', 'GRB2', 'PAK6', 'PLA2G4A', 'EXOC2', 'FGF16', 'CALML3', 'GRIN2A', 'KIT', 'GNGT1', 'KDR', 'FGF3', 'RASGRP2', 'PIK3CB', 'KRAS', 'IKBKB', 'GNG11', 'RAP1B', 'PLA2G4E', 'GAB1', 'BCL2L1', 'FGF12', 'RGL1', 'PRKCB', 'CALM2', 'FGF13', 'HGF', 'ELK1', 'RAB5C', 'MAPK1', 'GNG7', 'PLA2G2F', 'EFNA1', 'RASA3', 'GNG10', 'PIK3CA', 'RASGRF1', 'MRAS', 'MLLT4', 'SYNGAP1', 'NFKB1', 'RASA4B', 'GNB4', 'MAP2K1', 'MAPK8', 'PIK3R2', 'GNG2', 'PLCE1', 'VEGFC', 'FGF5', 'PLA2G6', 'PAK2', 'RRAS2', 'EFNA2', 'FGF9', 'RASSF5', 'INS', 'VEGFB', 'MAPK3', 'CALM3', 'ANGPT4', 'ANGPT2', 'RASAL2', 'RALA', 'FGFR4', 'MAPK9', 'PLA2G1B', 'LAT', 'GNG8', 'FGF11', 'NGF', 'NF1', 'SHC2', 'RASGRP1', 'PIK3CG', 'ARF6', 'EFNA3', 'GNG13', 'FGF14', 'CSF1R', 'KSR1', 'FGF23', 'RALBP1', 'BAD', 'RAC3', 'RAC2', 'HRAS', 'PLA2G10', 'PIK3R5', 'EGF', 'PLA2G4D', 'REL', 'FGF1', 'PLA2G2C', 'SHC3', 'TEK', 'GNB1', 'EGFR', 'SHC1', 'AKT1', 'MET', 'GNG4', 'PRKACA', 'PAK7', 'FGF6', 'PLD1', 'PLA2G4B', 'NRAS', 'ABL1', 'PDGFA', 'PDGFRB', 'PDGFC', 'PLA2G4F', 'PDGFB', 'PRKACG', 'RAB5B', 'PRKCA', 'KITLG', 'RAPGEF5', 'MAP2K2', 'FGF7', 'RASGRF2', 'RASSF1', 'ZAP70', 'PAK4', 'PAK1', 'PAK3', 'IKBKG', 'IGF1', 'RRAS', 'PRKCG', 'FGFR3', 'PRKACB', 'PIK3R3', 'FLT1', 'PDGFRA', 'CALML5'}, 'Rap1 signaling pathway Homo sapiens hsa04015': {'IGF1R', 'PRKD3', 'FLT4', 'ADCY9', 'ADCY3', 'DOCK4', 'ADCY6', 'FGF10', 'TIAM1', 'LPAR5', 'FGF8', 'PIK3R1', 'GRIN2B', 'FGFR1', 'AKT3', 'RAF1', 'PARD6G', 'SIPA1L2', 'FIGF', 'ANGPT1', 'TLN2', 'FGF17', 'MAPK14', 'CSF1', 'GNAI1', 'MAGI2', 'PLCG1', 'CALM1', 'LPAR1', 'MAPK11', 'GRIN1', 'ADORA2A', 'SIPA1L3', 'CDH1', 'VEGFA', 'PRKCI', 'FGF2', 'FGF21', 'ADCY7', 'FGF18', 'GNAO1', 'PIK3CD', 'FGF20', 'RALB', 'MAP2K6', 'BRAF', 'CTNNB1', 'RAP1A', 'RAC1', 'ARAP3', 'CALML6', 'FGF19', 'PGF', 'TLN1', 'INSR', 'NGFR', 'FGF22', 'RHOA', 'RASGRP3', 'CDC42', 'KRIT1', 'PFN2', 'THBS1', 'RAP1GAP', 'AKT2', 'LPAR3', 'EFNA4', 'PDGFD', 'VAV2', 'EFNA5', 'FGFR2', 'PRKD2', 'RAPGEF2', 'FGF4', 'EPHA2', 'PLCB1', 'RALGDS', 'ITGB3', 'FGF16', 'CALML3', 'GRIN2A', 'KIT', 'PRKCZ', 'KDR', 'FGF3', 'RASGRP2', 'PIK3CB', 'KRAS', 'PARD6B', 'P2RY1', 'ADCY4', 'RAP1B', 'PLCB4', 'ID1', 'FPR1', 'PARD3', 'FGF12', 'RAPGEF6', 'PRKCB', 'CALM2', 'FGF13', 'HGF', 'MAPK1', 'ADORA2B', 'PFN3', 'EFNA1', 'PLCB2', 'PIK3CA', 'CNR1', 'GNAI2', 'ADCY2', 'MRAS', 'RAPGEF1', 'MAPK13', 'ADCY8', 'MLLT4', 'FYB', 'MAP2K1', 'MAP2K3', 'BCAR1', 'PIK3R2', 'ITGB1', 'ADCY5', 'LPAR2', 'PLCE1', 'VEGFC', 'ITGA2B', 'FGF5', 'EFNA2', 'FGF9', 'RASSF5', 'SRC', 'INS', 'VEGFB', 'MAPK3', 'CALM3', 'APBB1IP', 'ANGPT4', 'ANGPT2', 'FGFR4', 'RALA', 'MAGI3', 'GNAQ', 'PFN4', 'LAT', 'FGF11', 'PARD6A', 'NGF', 'RAPGEF3', 'PRKD1', 'ACTB', 'ADCY1', 'PLCB3', 'PIK3CG', 'EFNA3', 'FGF14', 'RGS14', 'CSF1R', 'FGF23', 'RAC3', 'LPAR4', 'RAC2', 'HRAS', 'PIK3R5', 'EGF', 'FGF1', 'MET', 'TEK', 'EGFR', 'AKT1', 'VASP', 'FGF6', 'NRAS', 'PDGFA', 'PDGFRB', 'PDGFC', 'PDGFB', 'MAPK12', 'PRKCA', 'KITLG', 'MAGI1', 'RAPGEF5', 'F2RL3', 'ACTG1', 'MAP2K2', 'DRD2', 'FGF7', 'ITGAL', 'ITGAM', 'SIPA1', 'FARP2', 'F2R', 'SIPA1L1', 'GNAI3', 'CRKL', 'LCP2', 'ITGB2', 'CTNND1', 'IGF1', 'PFN1', 'CRK', 'RRAS', 'PRKCG', 'GNAS', 'RAPGEF4', 'SKAP1', 'FGFR3', 'PIK3R3', 'FLT1', 'PDGFRA', 'CALML5'}, 'Regulation of actin cytoskeleton Homo sapiens hsa04810': {'ITGB4', 'CHRM1', 'DIAPH1', 'FGF10', 'VCL', 'TIAM1', 'FGF8', 'PIK3R1', 'MYLK3', 'FN1', 'FGFR1', 'RAF1', 'GIT1', 'ITGB8', 'ITGA8', 'FGF17', 'ITGA9', 'ARAF', 'IQGAP3', 'PIP4K2A', 'LIMK1', 'ITGA2', 'FGD1', 'ITGA11', 'MYL5', 'FGF2', 'FGF21', 'CYFIP2', 'FGF18', 'PIK3CD', 'PIP5K1A', 'FGF20', 'PPP1CA', 'ITGAV', 'BDKRB2', 'BRAF', 'PIKFYVE', 'APC', 'F2', 'MYLK4', 'RAC1', 'PPP1CC', 'EZR', 'FGF19', 'ARPC1A', 'SOS2', 'ITGB5', 'SOS1', 'DIAPH2', 'FGF22', 'LIMK2', 'RHOA', 'GNG12', 'PIP4K2B', 'ACTN4', 'CDC42', 'PFN2', 'RDX', 'TMSB4X', 'CFL1', 'MYH14', 'DIAPH3', 'PDGFD', 'SSH2', 'PIP5K1B', 'VAV2', 'VAV3', 'FGFR2', 'FGF4', 'MYL12B', 'PIP5K1C', 'ITGAE', 'ITGA4', 'ITGB3', 'GNA13', 'PAK6', 'ACTN2', 'FGF16', 'MYL10', 'MYL12A', 'FGF3', 'PIK3CB', 'KRAS', 'CHRM5', 'ITGA5', 'IQGAP1', 'MYLK', 'GSN', 'MYH10', 'APC2', 'ENAH', 'FGF12', 'FGF13', 'ARHGEF1', 'FGD3', 'WASF2', 'IQGAP2', 'MYLK2', 'ITGB7', 'ITGA3', 'MOS', 'ITGAX', 'MAPK1', 'MYL9', 'CHRM4', 'PFN3', 'ITGAD', 'PPP1R12C', 'ARPC4', 'DOCK1', 'ITGA1', 'PIK3CA', 'MRAS', 'WAS', 'MSN', 'MAP2K1', 'BCAR1', 'PIK3R2', 'ARPC2', 'NCKAP1', 'ITGB1', 'ITGA2B', 'FGF5', 'BDKRB1', 'PAK2', 'RRAS2', 'ARHGAP35', 'FGF9', 'ITGA6', 'INS', 'SRC', 'TMSB4Y', 'CHRM3', 'SSH1', 'SLC9A1', 'MAPK3', 'VAV1', 'CD14', 'CYFIP1', 'ACTN3', 'FGFR4', 'INSRR', 'PFN4', 'FGF11', 'WASL', 'ITGA10', 'ACTB', 'ARPC3', 'PIK3CG', 'NCKAP1L', 'CFL2', 'FGF14', 'PPP1CB', 'PPP1R12A', 'ARHGEF7', 'ABI2', 'FGF23', 'RAC3', 'MYLPF', 'RAC2', 'BRK1', 'PTK2', 'ROCK2', 'HRAS', 'GNA12', 'PIK3R5', 'ACTN1', 'EGF', 'ARHGEF6', 'ARHGEF4', 'SSH3', 'FGF1', 'EGFR', 'WASF1', 'PAK7', 'ARPC5L', 'FGF6', 'ARPC5', 'BAIAP2', 'MYH9', 'NRAS', 'ROCK1', 'PDGFA', 'PDGFRB', 'PDGFC', 'PDGFB', 'ITGB6', 'MYL2', 'MAP2K2', 'ACTG1', 'FGF7', 'ITGAL', 'ITGAM', 'MYL7', 'PIP4K2C', 'PAK4', 'PAK1', 'F2R', 'ITGA7', 'PAK3', 'CRKL', 'SCIN', 'PXN', 'ITGB2', 'PPP1R12B', 'CHRM2', 'PFN1', 'CRK', 'RRAS', 'ARPC1B', 'FGFR3', 'PIK3R3', 'PDGFRA', 'ARHGEF12'}, 'Focal adhesion Homo sapiens hsa04510': {'IGF1R', 'ITGB4', 'LAMC3', 'FLT4', 'TNXB', 'DIAPH1', 'FLNC', 'VCL', 'CAV3', 'MYLK3', 'PIK3R1', 'FN1', 'AKT3', 'RAF1', 'FIGF', 'TLN2', 'SPP1', 'THBS3', 'ITGB8', 'COL9A1', 'ITGA8', 'PTEN', 'ITGA9', 'LAMB2', 'COL9A3', 'CCND1', 'LAMA1', 'COL4A2', 'ITGA2', 'VEGFA', 'ITGA11', 'MYL5', 'SHC4', 'CCND2', 'PIK3CD', 'GSK3B', 'PPP1CA', 'ITGAV', 'TNR', 'BRAF', 'CTNNB1', 'LAMC2', 'RAP1A', 'RAC1', 'LAMA4', 'PPP1CC', 'MYLK4', 'SOS2', 'PGF', 'MAPK10', 'ITGB5', 'TLN1', 'SOS1', 'CAPN2', 'RHOA', 'PARVG', 'CDC42', 'ACTN4', 'THBS1', 'AKT2', 'COL6A6', 'LAMA3', 'PDGFD', 'VAV2', 'VAV3', 'THBS4', 'THBS2', 'MYL12B', 'PIP5K1C', 'ITGA4', 'GRB2', 'ITGB3', 'PAK6', 'ACTN2', 'MYL10', 'MYL12A', 'KDR', 'COL4A1', 'PIK3CB', 'PDPK1', 'ITGA5', 'RAP1B', 'MYLK', 'LAMB4', 'FLNB', 'RELN', 'TNC', 'PRKCB', 'LAMA5', 'VWF', 'COL4A5', 'BIRC2', 'MYLK2', 'HGF', 'ELK1', 'ITGB7', 'BIRC3', 'ITGA3', 'MAPK1', 'MYL9', 'COL6A2', 'CHAD', 'PARVB', 'CAV1', 'COMP', 'PPP1R12C', 'ITGA1', 'DOCK1', 'PIK3CA', 'RASGRF1', 'ZYX', 'RAPGEF1', 'COL6A1', 'COL1A1', 'VTN', 'ARHGAP5', 'MAP2K1', 'MAPK8', 'BCAR1', 'COL6A3', 'LAMB1', 'PIK3R2', 'ITGB1', 'VEGFC', 'ITGA2B', 'PAK2', 'ARHGAP35', 'COL4A6', 'IBSP', 'ITGA6', 'SRC', 'TNN', 'VEGFB', 'LAMA2', 'MAPK3', 'VAV1', 'ACTN3', 'JUN', 'COL6A5', 'ILK', 'MAPK9', 'LAMB3', 'ERBB2', 'COL9A2', 'ITGA10', 'ACTB', 'SHC2', 'PIK3CG', 'PPP1R12A', 'PPP1CB', 'BAD', 'MYLPF', 'XIAP', 'RAC3', 'RAC2', 'PTK2', 'ROCK2', 'HRAS', 'PIK3R5', 'ACTN1', 'EGF', 'MET', 'SHC3', 'EGFR', 'SHC1', 'AKT1', 'CCND3', 'BCL2', 'CAV2', 'VASP', 'PAK7', 'ROCK1', 'PDGFA', 'PDGFRB', 'PDGFC', 'PDGFB', 'COL4A3', 'ITGB6', 'PRKCA', 'PARVA', 'MYL2', 'ACTG1', 'LAMC1', 'MYL7', 'PAK4', 'PAK1', 'ITGA7', 'FYN', 'PAK3', 'COL4A4', 'CRKL', 'PXN', 'COL1A2', 'PPP1R12B', 'IGF1', 'CRK', 'PRKCG', 'FLNA', 'COL2A1', 'PIK3R3', 'FLT1', 'PDGFRA'}, 'ECM-receptor interaction Homo sapiens hsa04512': {'ITGB4', 'LAMC3', 'TNXB', 'CD47', 'FN1', 'CD44', 'SPP1', 'THBS3', 'ITGB8', 'COL9A1', 'ITGA8', 'ITGA9', 'LAMB2', 'COL9A3', 'LAMA1', 'ITGA2', 'COL4A2', 'GP6', 'SV2A', 'ITGA11', 'SV2C', 'AGRN', 'CD36', 'ITGAV', 'TNR', 'LAMC2', 'LAMA4', 'ITGB5', 'THBS1', 'COL6A6', 'LAMA3', 'THBS4', 'THBS2', 'ITGA4', 'ITGB3', 'DAG1', 'COL4A1', 'ITGA5', 'LAMB4', 'RELN', 'TNC', 'LAMA5', 'VWF', 'COL4A5', 'ITGB7', 'ITGA3', 'COL6A2', 'CHAD', 'COMP', 'ITGA1', 'COL6A1', 'COL1A1', 'VTN', 'COL6A3', 'LAMB1', 'GP9', 'ITGB1', 'ITGA2B', 'HMMR', 'COL4A6', 'ITGA6', 'GP1BA', 'IBSP', 'TNN', 'LAMA2', 'SDC4', 'COL6A5', 'HSPG2', 'LAMB3', 'SDC1', 'COL9A2', 'ITGA10', 'GP1BB', 'GP5', 'COL4A3', 'ITGB6', 'LAMC1', 'ITGA7', 'SV2B', 'COL4A4', 'COL1A2', 'COL2A1'}, 'PI3K-Akt signaling pathway Homo sapiens hsa04151': {'CHRM1', 'PPP2R5B', 'FLT4', 'FGF10', 'CDC37', 'FGF8', 'AKT3', 'THBS3', 'LPAR6', 'ITGA9', 'RELA', 'COL9A3', 'BCL2L11', 'LAMA1', 'FGF2', 'PIK3CD', 'PCK1', 'ITGAV', 'PGF', 'GNG12', 'YWHAG', 'CREB3L1', 'THBS1', 'YWHAB', 'LAMA3', 'EFNA4', 'IFNA8', 'PDGFD', 'THBS4', 'PKN1', 'IFNA2', 'IFNA10', 'EPHA2', 'PPP2R2B', 'FGF16', 'IFNB1', 'FGF3', 'ITGA5', 'PPP2R3A', 'TP53', 'BCL2L1', 'GYS1', 'IFNA16', 'FGF13', 'COL4A5', 'PHLPP2', 'GYS2', 'C8ORF44-SGK3', 'COL6A2', 'ITGA1', 'COL1A1', 'GNB4', 'COL4A6', 'TNN', 'VEGFB', 'LAMA2', 'MAPK3', 'ANGPT4', 'PKN3', 'PPP2R2A', 'FGF11', 'COL9A2', 'ITGA10', 'CREB1', 'PIK3CG', 'GNG13', 'CSF1R', 'LOC102723407', 'EPOR', 'IL4', 'PIK3R5', 'TEK', 'CSH1', 'PIK3AP1', 'NRAS', 'PDGFA', 'JAK2', 'EIF4E1B', 'F2R', 'STK11', 'DDIT4', 'COL4A4', 'COL1A2', 'TSC2', 'IRS1', 'YWHAH', 'IGF1R', 'ITGB4', 'LPAR5', 'CHUK', 'YWHAQ', 'FGFR1', 'NR4A1', 'FIGF', 'ANGPT1', 'IFNA5', 'PTEN', 'LAMB2', 'OSM', 'CCND1', 'ITGA2', 'FGF18', 'PPP2R1B', 'RAC1', 'FGF19', 'ITGB5', 'CRTC2', 'RPS6', 'IFNA6', 'GNB2', 'COL6A6', 'GH1', 'G6PC2', 'CDKN1B', 'PKN2', 'G6PC3', 'RXRA', 'KIT', 'MCL1', 'KDR', 'COL4A1', 'PPP2R1A', 'RELN', 'CSH2', 'IL2RA', 'PRL', 'MTCP1', 'NFKB1', 'PPP2R5D', 'PIK3R2', 'LAMB1', 'GNG2', 'IL6R', 'ITGA2B', 'FGF5', 'EFNA2', 'IBSP', 'INS', 'RPTOR', 'COL6A5', 'FGFR4', 'IL3', 'GNG8', 'IFNAR2', 'TCL1A', 'EFNA3', 'FGF14', 'LPAR4', 'EGF', 'EGFR', 'AKT1', 'CCND3', 'PDGFRB', 'PDGFC', 'PDGFB', 'COL4A3', 'IL2RG', 'ITGB6', 'IL7R', 'KITLG', 'PPP2R3C', 'LAMC1', 'FGF7', 'IL6', 'MYC', 'EIF4EBP1', 'PRLR', 'IKBKG', 'ATF6B', 'IFNA17', 'CHRM2', 'FOXO3', 'MLST8', 'JAK1', 'CDKN1A', 'CREB3L3', 'TLR4', 'TCL1B', 'GNB3', 'PIK3R1', 'FN1', 'RAF1', 'CREB3L4', 'SPP1', 'RBL2', 'ITGB8', 'ITGA8', 'CSF1', 'EIF4E', 'MTOR', 'IFNA21', 'PPP2R2C', 'CDK2', 'VEGFA', 'ITGA11', 'FASLG', 'CCND2', 'GSK3B', 'PRKAA1', 'SOS2', 'GNG3', 'FGF22', 'PPP2CB', 'IL7', 'AKT2', 'HSP90B1', 'IFNA1', 'IFNA13', 'EFNA5', 'THBS2', 'CDK6', 'FGF4', 'YWHAE', 'GRB2', 'CASP9', 'PDPK1', 'CCNE1', 'HSP90AA1', 'EPO', 'CSF3', 'LAMA5', 'SGK3', 'OSMR', 'ITGA3', 'MAPK1', 'COMP', 'PIK3CA', 'COL6A1', 'LPAR2', 'VEGFC', 'PPP2R5C', 'ITGA6', 'PCK2', 'ANGPT2', 'PPP2R5A', 'BRCA1', 'PTK2', 'CD19', 'HRAS', 'MET', 'PPP2R5E', 'BCL2', 'SYK', 'IL3RA', 'CREB3', 'RPS6KB2', 'PRKCA', 'IL2', 'CREB3L2', 'ITGA7', 'JAK3', 'IGF1', 'CCNE2', 'PIK3R3', 'FLT1', 'IL4R', 'LAMC3', 'TNXB', 'GNGT2', 'IFNA7', 'GNB5', 'COL9A1', 'FGF17', 'GNG5', 'LPAR1', 'COL4A2', 'FGF21', 'HSP90AB1', 'FGF20', 'RPS6KB1', 'TNR', 'LAMC2', 'LAMA4', 'GHR', 'INSR', 'SOS1', 'NGFR', 'EIF4B', 'LPAR3', 'PPP2CA', 'MYB', 'FGFR2', 'ITGA4', 'PRKAA2', 'ITGB3', 'GNGT1', 'PIK3CB', 'KRAS', 'IKBKB', 'GNG11', 'LAMB4', 'IL2RB', 'NOS3', 'TNC', 'PPP2R3B', 'MDM2', 'FGF12', 'CSF3R', 'VWF', 'HGF', 'ITGB7', 'G6PC', 'GNG7', 'EIF4E2', 'CHAD', 'EFNA1', 'GNG10', 'VTN', 'GH2', 'ATF4', 'IFNAR1', 'PHLPP1', 'MAP2K1', 'COL6A3', 'CREB5', 'ITGB1', 'IFNA4', 'FGF9', 'YWHAZ', 'SGK2', 'LAMB3', 'RHEB', 'THEM4', 'NGF', 'ATF2', 'FGF23', 'BAD', 'FGF1', 'GNB1', 'SGK1', 'GNG4', 'FGF6', 'CDK4', 'MAP2K2', 'IFNA14', 'TLR2', 'TSC1', 'FGFR3', 'COL2A1', 'PPP2R2D', 'PDGFRA'}, 'Pathways in cancer Homo sapiens hsa05200': {'TCF7L1', 'ADCY6', 'ARNT2', 'FGF10', 'FGF8', 'TRAF5', 'AKT3', 'MMP2', 'PLEKHG5', 'GNA11', 'FZD9', 'LPAR6', 'RELA', 'LAMA1', 'FGF2', 'ADCY7', 'PIK3CD', 'EGLN2', 'NTRK1', 'ITGAV', 'ARNT', 'PGF', 'CASP8', 'GNG12', 'APPL1', 'ETS1', 'LAMA3', 'TCF7L2', 'TFG', 'WNT5B', 'TGFB1', 'AXIN1', 'PLCB1', 'SMAD2', 'FGF16', 'FGF3', 'E2F2', 'PLCB4', 'TPR', 'APC2', 'TP53', 'BMP4', 'BCL2L1', 'PRKCB', 'EDNRB', 'FGF13', 'COL4A5', 'DCC', 'BID', 'GNAI2', 'MSH6', 'BAX', 'FZD10', 'GNB4', 'MAX', 'COL4A6', 'RASSF5', 'VEGFB', 'LAMA2', 'MAPK3', 'RALA', 'FH', 'MSH3', 'GNAQ', 'FGF11', 'PIK3CG', 'EGLN3', 'GNG13', 'CSF1R', 'TGFBR1', 'MMP9', 'FZD4', 'GNA12', 'PIK3R5', 'DVL2', 'PRKACA', 'BIRC8', 'NRAS', 'PDGFA', 'AXIN2', 'WNT10A', 'WNT2', 'FZD3', 'F2R', 'MMP1', 'TGFB3', 'COL4A4', 'CRKL', 'E2F1', 'WNT16', 'RAD51', 'IGF1R', 'CKS2', 'STAT5B', 'LPAR5', 'CHUK', 'FZD7', 'CSF2RA', 'FGFR1', 'RBX1', 'LEF1', 'FIGF', 'FLT3LG', 'TRAF2', 'SKP2', 'PTEN', 'LAMB2', 'ARAF', 'CCND1', 'ITGA2', 'STK4', 'WNT9B', 'FGF18', 'RASGRP4', 'RALB', 'APC', 'RAC1', 'FGF19', 'WNT2B', 'RASGRP3', 'GNB2', 'CDKN1B', 'TGFB2', 'WNT7B', 'BIRC5', 'RUNX1', 'E2F3', 'RXRA', 'KIT', 'COL4A1', 'ADCY4', 'PML', 'NOS2', 'ARHGEF1', 'BIRC2', 'TRAF3', 'MECOM', 'SHH', 'NFKB1', 'CBL', 'MAPK8', 'CTNNA3', 'PIK3R2', 'DAPK3', 'LAMB1', 'GNG2', 'ADCY5', 'ITGA2B', 'FGF5', 'EP300', 'NKX3-1', 'JUN', 'MAPK9', 'SLC2A1', 'STAT1', 'GNG8', 'HHIP', 'RASGRP1', 'FGF14', 'CBLB', 'RAC3', 'FOS', 'LPAR4', 'ROCK2', 'EGF', 'TRAF6', 'EGFR', 'AKT1', 'ABL1', 'PDGFRB', 'PDGFB', 'COL4A3', 'KITLG', 'CTNNA1', 'LAMC1', 'NFKB2', 'FGF7', 'IL6', 'RASSF1', 'MYC', 'TCEB1', 'TGFBR2', 'CEBPA', 'WNT9A', 'PTCH2', 'IKBKG', 'FZD2', 'GNAI3', 'RET', 'CRK', 'RARB', 'GNAS', 'TCEB2', 'SMAD3', 'JAK1', 'CTBP1', 'ARHGEF12', 'CDKN1A', 'TCF7', 'ADCY3', 'WNT8B', 'WNT5A', 'GNB3', 'PIK3R1', 'FN1', 'RAF1', 'FLT3', 'PAX8', 'STK36', 'CDKN2B', 'FZD1', 'JUP', 'MTOR', 'CXCL8', 'CDH1', 'CDK2', 'CXCL12', 'VEGFA', 'FASLG', 'GSK3B', 'CTNNB1', 'HDAC1', 'SOS2', 'GNG3', 'FGF22', 'RHOA', 'WNT4', 'AKT2', 'HSP90B1', 'VHL', 'CDK6', 'FGF4', 'GRB2', 'GNA13', 'KLK3', 'BIRC7', 'CASP9', 'AGTR1', 'RASGRP2', 'CCNE1', 'HSP90AA1', 'GLI2', 'FADD', 'LAMA5', 'SMAD4', 'BIRC3', 'ITGA3', 'MAPK1', 'PIK3CA', 'BCR', 'CDKN2A', 'CYCS', 'HDAC2', 'LPAR2', 'VEGFC', 'BDKRB1', 'ITGA6', 'RB1', 'FAS', 'RXRB', 'PPARD', 'ADCY1', 'PLCB3', 'WNT6', 'RALBP1', 'PTK2', 'HRAS', 'MET', 'BCL2', 'PLD1', 'PRKACG', 'PRKCA', 'CREBBP', 'WNT1', 'WNT10B', 'GSTP1', 'FOXO1', 'CCDC6', 'IGF1', 'PRKCG', 'CCNE2', 'PTGER4', 'PIK3R3', 'WNT7A', 'RUNX1T1', 'LAMC3', 'ADCY9', 'BMP2', 'GNGT2', 'GNB5', 'PTGER1', 'FGF17', 'GNG5', 'GNAI1', 'PLCG1', 'LPAR1', 'STAT3', 'COL4A2', 'CTBP2', 'BRCA2', 'TPM3', 'RXRG', 'HSP90AB1', 'FGF21', 'ARHGEF11', 'FGF20', 'BDKRB2', 'BRAF', 'LAMC2', 'LAMA4', 'MAPK10', 'WNT11', 'SOS1', 'PIAS2', 'CDC42', 'TGFA', 'TRAF4', 'LPAR3', 'PLCG2', 'MSH2', 'STAT5A', 'FZD8', 'FGFR2', 'CCNA1', 'EPAS1', 'RALGDS', 'CXCR4', 'MLH1', 'DVL1', 'DVL3', 'GNGT1', 'PIK3CB', 'KRAS', 'IKBKB', 'GNG11', 'LAMB4', 'EGLN1', 'PTCH1', 'MDM2', 'FGF12', 'SUFU', 'CSF3R', 'CUL2', 'HGF', 'CBLC', 'CKS1B', 'GNG7', 'CTNNA2', 'WNT3A', 'FZD5', 'PLCB2', 'GNG10', 'ADCY2', 'ADCY8', 'MAP2K1', 'GLI3', 'HIF1A', 'ITGB1', 'NFKBIA', 'RARA', 'FGF9', 'PTGS2', 'PTGER2', 'ZBTB16', 'LAMB3', 'NCOA4', 'ERBB2', 'MITF', 'SPI1', 'EDNRA', 'FGF23', 'BAD', 'XIAP', 'RAC2', 'SMO', 'FGF1', 'GNB1', 'DAPK2', 'WNT8A', 'GNG4', 'FZD6', 'FGF6', 'CDK4', 'ROCK1', 'PTGER3', 'DAPK1', 'CASP3', 'F2RL3', 'GLI1', 'MAP2K2', 'TRAF1', 'WNT3', 'AR', 'FGFR3', 'PRKACB', 'PPARG', 'PDGFRA'}, 'Small cell lung cancer Homo sapiens hsa05222': {'LAMC3', 'CKS2', 'CHUK', 'PIK3R1', 'TRAF5', 'FN1', 'AKT3', 'TRAF2', 'SKP2', 'PTEN', 'RELA', 'LAMB2', 'CDKN2B', 'CCND1', 'LAMA1', 'ITGA2', 'COL4A2', 'CDK2', 'RXRG', 'PIK3CD', 'ITGAV', 'LAMC2', 'LAMA4', 'PIAS2', 'AKT2', 'TRAF4', 'LAMA3', 'CDKN1B', 'CDK6', 'E2F3', 'RXRA', 'BIRC7', 'CASP9', 'PIK3CB', 'COL4A1', 'IKBKB', 'E2F2', 'APAF1', 'CCNE1', 'LAMB4', 'TP53', 'BCL2L1', 'LAMA5', 'NOS2', 'COL4A5', 'BIRC2', 'TRAF3', 'BIRC3', 'CKS1B', 'ITGA3', 'PIK3CA', 'NFKB1', 'CYCS', 'PIK3R2', 'LAMB1', 'ITGB1', 'MAX', 'NFKBIA', 'ITGA2B', 'COL4A6', 'ITGA6', 'PTGS2', 'LAMA2', 'RB1', 'RXRB', 'LAMB3', 'PIK3CG', 'XIAP', 'PTK2', 'PIK3R5', 'TRAF6', 'AKT1', 'BCL2', 'BIRC8', 'CDK4', 'COL4A3', 'LAMC1', 'TRAF1', 'MYC', 'IKBKG', 'COL4A4', 'FHIT', 'E2F1', 'RARB', 'CCNE2', 'PIK3R3'}, 'Apoptosis Homo sapiens hsa04210': {'MAP3K5', 'ENDOG', 'BAK1', 'CHUK', 'CTSW', 'PIK3R1', 'RAF1', 'AKT3', 'CTSC', 'DFFB', 'CSF2RB', 'TRAF2', 'EIF2S1', 'CASP10', 'MAP3K14', 'CTSH', 'RELA', 'PRF1', 'BCL2L11', 'LMNB1', 'ITPR3', 'GADD45A', 'GADD45G', 'DDIT3', 'TNF', 'TUBA8', 'PMAIP1', 'ITPR2', 'FASLG', 'PIK3CD', 'NTRK1', 'DIABLO', 'TP53AIP1', 'MAPK10', 'CASP8', 'CAPN2', 'PTPN13', 'LMNA', 'AKT2', 'CASP2', 'CTSL', 'CFLAR', 'BIRC5', 'TUBAL3', 'CASP12', 'TNFRSF10D', 'ITPR1', 'TUBA1C', 'MCL1', 'CTSD', 'CASP9', 'PIK3CB', 'KRAS', 'IKBKB', 'PDPK1', 'APAF1', 'CTSK', 'FADD', 'PARP1', 'TP53', 'CTSZ', 'BCL2L1', 'TUBA4A', 'PARP2', 'BIRC2', 'SPTA1', 'BIRC3', 'MAPK1', 'DAB2IP', 'TUBA3E', 'TNFRSF10B', 'BID', 'PIK3CA', 'BAX', 'SEPT4', 'HTRA2', 'NFKB1', 'ATF4', 'MAP2K1', 'MAPK8', 'CYCS', 'PIK3R2', 'BCL2A1', 'DFFA', 'CTSF', 'LMNB2', 'NFKBIA', 'PARP3', 'TNFSF10', 'PIDD1', 'TUBA3C', 'CASP6', 'MAPK3', 'JUN', 'FAS', 'AIFM1', 'MAPK9', 'ERN1', 'TUBA1B', 'IL3', 'BBC3', 'TUBA3D', 'NGF', 'ACTB', 'TNFRSF10C', 'PIK3CG', 'PARP4', 'BAD', 'CTSV', 'FOS', 'XIAP', 'GZMB', 'HRAS', 'PIK3R5', 'TRADD', 'SPTAN1', 'AKT1', 'TNFRSF10A', 'CTSB', 'BCL2', 'CAPN1', 'IL3RA', 'NRAS', 'ATM', 'CTSS', 'HRK', 'CASP3', 'GADD45B', 'RIPK1', 'ACTG1', 'MAP2K2', 'EIF2AK3', 'TRAF1', 'TUBA1A', 'CTSO', 'IKBKG', 'DAXX', 'CASP7', 'PIK3R3', 'TNFRSF1A'}, 'NF-kappa B signaling pathway Homo sapiens hsa04064': {'TIRAP', 'TLR4', 'CSNK2A2', 'CHUK', 'CSNK2A1', 'CCL4L1', 'TRAF5', 'TRAF2', 'CCL4L2', 'UBE2I', 'TICAM2', 'LTA', 'MAP3K14', 'RELA', 'PLCG1', 'CXCL8', 'CXCL12', 'TNF', 'BTK', 'TAB1', 'TNFAIP3', 'LTB', 'PLCG2', 'IRAK1', 'TICAM1', 'CFLAR', 'TAB3', 'TRIM25', 'TAB2', 'IKBKB', 'MAP3K7', 'IL1R1', 'PLAU', 'PARP1', 'CCL19', 'BCL2L1', 'ERC1', 'PRKCB', 'IL1B', 'BIRC2', 'TNFSF11', 'LBP', 'TRAF3', 'MYD88', 'LCK', 'BIRC3', 'TNFSF14', 'RELB', 'ICAM1', 'TNFRSF11A', 'NFKB1', 'BCL2A1', 'NFKBIA', 'PIDD1', 'PTGS2', 'CSNK2A3', 'BLNK', 'MALT1', 'CD14', 'PRKCQ', 'LAT', 'IRAK4', 'LYN', 'CCL13', 'LOC102723407', 'XIAP', 'CSNK2B', 'TNFRSF13C', 'TNFRSF1A', 'BCL10', 'TRADD', 'TRAF6', 'DDX58', 'BCL2', 'SYK', 'ATM', 'TNFSF13B', 'LY96', 'RIPK1', 'GADD45B', 'PIAS4', 'NFKB2', 'TRAF1', 'ZAP70', 'IKBKG', 'CD40LG', 'LTBR', 'CD40', 'CARD11', 'CCL4', 'CXCL2', 'CCL21', 'VCAM1'}, 'Osteoclast differentiation Homo sapiens hsa04380': {'IRF9', 'IFNG', 'LILRA5', 'CHUK', 'PIK3R1', 'AKT3', 'TYK2', 'FCGR3A', 'FCGR2C', 'PPP3CB', 'LILRB4', 'TRAF2', 'NFATC1', 'MAPK14', 'MAP3K14', 'LILRB2', 'CSF1', 'RELA', 'FCGR2A', 'IFNGR2', 'STAT2', 'FOSL2', 'GAB2', 'PPP3R2', 'MAPK11', 'SIRPA', 'FHL2', 'TNF', 'NOX1', 'BTK', 'PIK3CD', 'LILRA6', 'MAP2K6', 'SIRPG', 'TAB1', 'RAC1', 'MAPK10', 'LILRA4', 'AKT2', 'PLCG2', 'LILRA2', 'PPP3CC', 'TGFB2', 'CYBB', 'NCF4', 'TGFB1', 'GRB2', 'SQSTM1', 'ITGB3', 'IFNGR1', 'CYBA', 'LILRB1', 'MAP2K7', 'TAB2', 'TNFRSF11B', 'IFNB1', 'PPARG', 'PIK3CB', 'TREM2', 'IKBKB', 'MAP3K7', 'CTSK', 'IL1R1', 'CALCR', 'ACP5', 'TEC', 'IL1A', 'NCF1', 'SOCS1', 'CYLD', 'LILRA1', 'IL1B', 'TNFSF11', 'FCGR1A', 'NOX3', 'FCGR2B', 'LCK', 'RELB', 'MAPK1', 'JUNB', 'PIK3CA', 'LILRB3', 'TNFRSF11A', 'LILRB5', 'MAPK13', 'OSCAR', 'NFKB1', 'IFNAR1', 'MAP2K1', 'MAPK8', 'JUND', 'PIK3R2', 'NFATC2', 'NFKBIA', 'MAPK3', 'BLNK', 'FOSL1', 'JUN', 'PPP3R1', 'MAPK9', 'LILRA3', 'PPP3CA', 'STAT1', 'LOC102725035', 'IFNAR2', 'CREB1', 'PIK3CG', 'NCF2', 'MITF', 'CAMK4', 'CSF1R', 'SPI1', 'TGFBR1', 'FCGR3B', 'FOS', 'PIK3R5', 'TRAF6', 'AKT1', 'SYK', 'FOSB', 'MAPK12', 'NFKB2', 'TGFBR2', 'FYN', 'IKBKG', 'TYROBP', 'LCP2', 'SIRPB1', 'SOCS3', 'PIK3R3', 'TNFRSF1A', 'JAK1'}, 'TNF signaling pathway Homo sapiens hsa04668': {'MAP3K5', 'CHUK', 'RPS6KA4', 'PIK3R1', 'TRAF5', 'AKT3', 'CREB3L4', 'IL15', 'MMP14', 'TRAF2', 'NOD2', 'LTA', 'MAPK14', 'MAP3K14', 'CASP10', 'BAG4', 'CSF1', 'RELA', 'MAPK11', 'TNF', 'PIK3CD', 'MAP2K6', 'TAB1', 'MAPK10', 'BCL3', 'CASP8', 'CCL5', 'MAP2K4', 'CXCL2', 'CREB3L1', 'TNFAIP3', 'AKT2', 'DNM1L', 'CXCL3', 'CFLAR', 'TAB3', 'LIF', 'MAP2K7', 'CXCL1', 'TAB2', 'PIK3CB', 'CEBPB', 'CXCL10', 'IKBKB', 'MAP3K7', 'FADD', 'ITCH', 'IL1B', 'BIRC2', 'TRAF3', 'BIRC3', 'TNFRSF1B', 'MAPK1', 'DAB2IP', 'ICAM1', 'JUNB', 'PIK3CA', 'IL18R1', 'MAPK13', 'SELE', 'NFKB1', 'ATF4', 'MAP2K1', 'MAPK8', 'MAP2K3', 'PIK3R2', 'CREB5', 'VEGFC', 'NFKBIA', 'CCL20', 'RPS6KA5', 'PTGS2', 'MAPK3', 'JUN', 'FAS', 'MAPK9', 'MMP3', 'CREB1', 'PIK3CG', 'ATF2', 'MMP9', 'FOS', 'EDN1', 'PIK3R5', 'MAP3K8', 'TRADD', 'CX3CL1', 'AKT1', 'CREB3', 'CASP3', 'MAPK12', 'MLKL', 'RIPK1', 'CREB3L2', 'IL6', 'TRAF1', 'PGAM5', 'CSF2', 'ATF6B', 'CCL2', 'IKBKG', 'RIPK3', 'CASP7', 'SOCS3', 'PIK3R3', 'TNFRSF1A', 'CXCL5', 'JAG1', 'VCAM1', 'CREB3L3'}, 'NOD-like receptor signaling pathway Homo sapiens hsa04621': {'IL1B', 'BIRC2', 'NLRP3', 'CASP8', 'BIRC3', 'MAPK1', 'CARD6', 'CCL5', 'IL18', 'NFKBIB', 'NOD1', 'CHUK', 'TNFAIP3', 'PSTPIP1', 'MEFV', 'HSP90B1', 'TRAF6', 'MAPK13', 'NAIP', 'CASP1', 'NFKB1', 'CARD9', 'MAPK10', 'NOD2', 'TAB3', 'MAPK14', 'NLRP1', 'MAPK8', 'RELA', 'MAPK12', 'PYCARD', 'CARD18', 'MAPK11', 'NFKBIA', 'CXCL8', 'IL6', 'CXCL1', 'TAB2', 'CARD8', 'RIPK2', 'TNF', 'ERBB2IP', 'MAPK3', 'IKBKB', 'HSP90AB1', 'MAP3K7', 'IKBKG', 'CCL2', 'HSP90AA1', 'NLRC4', 'MAPK9', 'CASP5', 'SUGT1', 'TAB1', 'CXCL2', 'PYDC1', 'TRIP6'}, 'Cytosolic DNA-sensing pathway Homo sapiens hsa04623': {'IL1B', 'ADAR', 'IL33', 'POLR3G', 'IFNA6', 'CCL5', 'IL18', 'NFKBIB', 'POLR3F', 'CHUK', 'POLR3C', 'POLR3GL', 'MAVS', 'CCL4L1', 'POLR2E', 'IFNA7', 'TMEM173', 'DDX58', 'IFNA1', 'CASP1', 'IFNA13', 'IFNA8', 'NFKB1', 'TREX1', 'CCL4L2', 'POLR3B', 'POLR2K', 'IFNA5', 'IFNA2', 'POLR2L', 'POLR3H', 'POLR3E', 'IRF7', 'RELA', 'POLR1D', 'IFNA10', 'POLR1C', 'RIPK1', 'PYCARD', 'POLR2F', 'POLR3A', 'AIM2', 'IFNA21', 'NFKBIA', 'IL6', 'IFNA4', 'IFNB1', 'ZBP1', 'IFNA14', 'CXCL10', 'IRF3', 'IKBKB', 'MB21D1', 'IKBKG', 'IFNA17', 'IKBKE', 'RIPK3', 'TBK1', 'POLR3D', 'CCL4', 'POLR3K', 'IFNA16', 'LOC101060521', 'POLR2H'}, 'RIG-I-like receptor signaling pathway Homo sapiens hsa04622': {'IL12A', 'CASP8', 'TRAF3', 'IFNE', 'IFNA6', 'IL12B', 'NFKBIB', 'CHUK', 'MAVS', 'TANK', 'IFNK', 'TBKBP1', 'IFNA7', 'TMEM173', 'PIN1', 'TRADD', 'TRAF6', 'DDX3X', 'DDX58', 'MAPK13', 'IFNA1', 'IFIH1', 'IFNA13', 'IFNA8', 'TRAF2', 'NFKB1', 'SIKE1', 'MAP3K1', 'OTUD5', 'IFNA5', 'MAPK14', 'CASP10', 'IRF7', 'IFNW1', 'RELA', 'IFNA10', 'IFNA2', 'MAPK8', 'MAPK12', 'RIPK1', 'ATG12', 'TRIM25', 'MAPK11', 'NFKBIA', 'CXCL8', 'RNF125', 'IFNA21', 'IFNA4', 'AZI2', 'ISG15', 'IFNB1', 'IFNA14', 'TNF', 'CXCL10', 'IRF3', 'IKBKB', 'MAP3K7', 'DHX58', 'IKBKG', 'NLRX1', 'FADD', 'IFNA17', 'MAPK9', 'DAK', 'IKBKE', 'TBK1', 'ATG5', 'IFNA16', 'CYLD', 'MAPK10'}, 'Toll-like receptor signaling pathway Homo sapiens hsa04620': {'TIRAP', 'TLR4', 'CHUK', 'PIK3R1', 'IFNA7', 'AKT3', 'IRF5', 'SPP1', 'CCL4L2', 'TICAM2', 'IFNA5', 'MAPK14', 'IRF7', 'RELA', 'MAPK11', 'IFNA21', 'CXCL8', 'TNF', 'TLR3', 'CD86', 'PIK3CD', 'TBK1', 'MAP2K6', 'TLR8', 'TAB1', 'RAC1', 'TLR5', 'TLR7', 'MAPK10', 'IL12A', 'CASP8', 'IFNA6', 'CCL5', 'MAP2K4', 'AKT2', 'IRAK1', 'IFNA1', 'IFNA13', 'IFNA8', 'TICAM1', 'CCL3L3', 'TOLLIP', 'IFNA2', 'IFNA10', 'MAP2K7', 'TAB2', 'IFNB1', 'PIK3CB', 'CXCL10', 'IKBKB', 'MAP3K7', 'CTSK', 'FADD', 'TLR9', 'IFNA16', 'IL1B', 'TRAF3', 'LBP', 'MYD88', 'TLR1', 'MAPK1', 'CD80', 'PIK3CA', 'MAPK13', 'NFKB1', 'IFNAR1', 'MAP2K1', 'MAPK8', 'MAP2K3', 'PIK3R2', 'NFKBIA', 'IFNA4', 'MAPK3', 'CD14', 'JUN', 'CCL3L1', 'MAPK9', 'IRAK4', 'STAT1', 'IFNAR2', 'PIK3CG', 'IL12B', 'FOS', 'PIK3R5', 'CCL3', 'CXCL11', 'MAP3K8', 'TRAF6', 'AKT1', 'TLR6', 'LY96', 'MAPK12', 'RIPK1', 'MAP2K2', 'IL6', 'IFNA14', 'TLR2', 'IRF3', 'IKBKG', 'CXCL9', 'IFNA17', 'CD40', 'IKBKE', 'CCL4', 'PIK3R3', 'CCL4L1'}, 'Hepatitis C Homo sapiens hsa05160': {'IRF9', 'PIAS1', 'IFIT1', 'CLDN7', 'CHUK', 'CLDN14', 'PIK3R1', 'IFNA7', 'RAF1', 'AKT3', 'TYK2', 'CLDN4', 'CLDN6', 'TRAF2', 'CLDN9', 'RNASEL', 'EIF2S1', 'IFNA5', 'MAPK14', 'IRF7', 'RELA', 'NR1H3', 'ARAF', 'STAT2', 'MAPK11', 'IFNA21', 'CXCL8', 'STAT3', 'PPP2R2C', 'CLDN20', 'TNF', 'TLR3', 'PIK3CD', 'GSK3B', 'CLDN15', 'TBK1', 'PPP2R1B', 'BRAF', 'SOS2', 'MAPK10', 'CLDN3', 'SOS1', 'IFNA6', 'PPP2CB', 'AKT2', 'PPP2CA', 'IFNA1', 'IFNA13', 'IFNA8', 'TICAM1', 'IFNA2', 'IFNA10', 'EIF2AK4', 'GRB2', 'PPP2R2B', 'RXRA', 'EIF2AK2', 'IFNB1', 'PIK3CB', 'KRAS', 'IKBKB', 'PDPK1', 'PPP2R1A', 'CD81', 'CLDN25', 'TP53', 'IFIT1B', 'CLDN17', 'IFNA16', 'TRAF3', 'MAPK1', 'PIK3CA', 'OAS3', 'MAPK13', 'NFKB1', 'OAS1', 'IFNAR1', 'MAPK8', 'EIF3E', 'PIK3R2', 'NFKBIA', 'IFNA4', 'PSME3', 'IRF1', 'PPARA', 'MAPK3', 'LDLR', 'MAPK9', 'PPP2R2A', 'CLDN8', 'STAT1', 'CLDN5', 'IFNAR2', 'PIK3CG', 'CLDN23', 'BAD', 'MAVS', 'HRAS', 'PIK3R5', 'EGF', 'CLDN22', 'TRAF6', 'EGFR', 'DDX58', 'AKT1', 'TRADD', 'SCARB1', 'CLDN10', 'CLDN1', 'NRAS', 'CLDN16', 'CLDN19', 'OAS2', 'MAPK12', 'RIPK1', 'EIF2AK3', 'EIF2AK1', 'IFNA14', 'CLDN2', 'CLDN11', 'IRF3', 'OCLN', 'IKBKG', 'IFNA17', 'CLDN24', 'IKBKE', 'SOCS3', 'PIK3R3', 'TNFRSF1A', 'PPP2R2D', 'JAK1', 'CLDN18', 'CDKN1A'}, 'Hepatitis B Homo sapiens hsa05161': {'TIRAP', 'TLR4', 'LAMTOR5', 'DDB1', 'STAT5B', 'CHUK', 'YWHAQ', 'PIK3R1', 'IFNA7', 'RAF1', 'AKT3', 'CREB3L4', 'EGR3', 'NFATC1', 'TICAM2', 'IFNA5', 'CASP10', 'PTEN', 'IRF7', 'RELA', 'CCNA2', 'STAT2', 'CCND1', 'PTK2B', 'IFNA21', 'STAT3', 'CXCL8', 'CDK2', 'TNF', 'TLR3', 'CDKN1A', 'FASLG', 'PIK3CD', 'TBK1', 'STAT4', 'DDB2', 'MAPK10', 'EGR2', 'CASP8', 'IFNA6', 'MAP2K4', 'CREB3L1', 'AKT2', 'YWHAB', 'IFIH1', 'IFNA1', 'STAT5A', 'IFNA13', 'CDKN1B', 'IFNA8', 'TGFB2', 'TICAM1', 'BIRC5', 'MAP3K1', 'CDK6', 'CASP12', 'IFNA2', 'TGFB1', 'CCNA1', 'IFNA10', 'E2F3', 'GRB2', 'IFNB1', 'CASP9', 'PIK3CB', 'KRAS', 'IKBKB', 'E2F2', 'APAF1', 'CCNE1', 'FADD', 'TP53', 'IFNA16', 'PRKCB', 'SMAD4', 'ELK1', 'MYD88', 'MAPK1', 'VDAC3', 'PIK3CA', 'BAX', 'NFKB1', 'ATF4', 'IFNAR1', 'MAP2K1', 'MAPK8', 'CYCS', 'PIK3R2', 'CREB5', 'NFATC2', 'ATP6AP1', 'NFKBIA', 'IFNA4', 'EP300', 'SRC', 'RB1', 'YWHAZ', 'MAPK3', 'JUN', 'FAS', 'MAPK9', 'HSPG2', 'PCNA', 'STAT1', 'CREB1', 'PIK3CG', 'ATF2', 'NFATC4', 'TGFBR1', 'MMP9', 'BAD', 'FOS', 'MAVS', 'HRAS', 'PIK3R5', 'DDX58', 'AKT1', 'DDX3X', 'BCL2', 'CDK4', 'NRAS', 'CREB3', 'CASP3', 'PRKCA', 'CREB3L2', 'MAP2K2', 'IL6', 'MYC', 'STAT6', 'IFNA14', 'TLR2', 'CREBBP', 'TGFB3', 'IRF3', 'NFATC3', 'IKBKG', 'ATF6B', 'IFNA17', 'E2F1', 'IKBKE', 'PRKCG', 'CCNE2', 'PIK3R3', 'SMAD3', 'JAK1', 'CREB3L3'}, 'Measles Homo sapiens hsa05162': {'IRF9', 'TLR4', 'CSNK2A2', 'IFNG', 'STAT5B', 'CHUK', 'DOK1', 'CSNK2A1', 'PIK3R1', 'TP73', 'IFNA7', 'AKT3', 'TYK2', 'EIF2S1', 'IFNA5', 'IRF7', 'RELA', 'IFNGR2', 'STAT2', 'CCND1', 'IFNA21', 'STAT3', 'CD3E', 'HSPA2', 'CDK2', 'FASLG', 'CCND2', 'PIK3CD', 'GSK3B', 'TBK1', 'SLAMF1', 'MX1', 'TLR7', 'IL12A', 'IFNA6', 'TACR1', 'CLEC4M', 'NFKBIB', 'TNFAIP3', 'AKT2', 'IFIH1', 'IRAK1', 'IFNA1', 'STAT5A', 'IFNA13', 'CDKN1B', 'IFNA8', 'CDK6', 'IFNA2', 'HSPA1A', 'TNFRSF10D', 'IFNA10', 'HSPA1B', 'EIF2AK4', 'IFNGR1', 'EIF2AK2', 'TAB2', 'CD3G', 'IFNB1', 'PIK3CB', 'CD209', 'MAP3K7', 'CCNE1', 'IL2RB', 'TLR9', 'IL1A', 'TP53', 'IFNA16', 'IL1B', 'IL2RA', 'FCGR2B', 'MYD88', 'IL13', 'HSPA8', 'TNFRSF10B', 'PIK3CA', 'HSPA6', 'OAS3', 'RAB9A', 'SH2D1A', 'NFKB1', 'OAS1', 'MSN', 'EIF3H', 'IFNAR1', 'CD3D', 'PIK3R2', 'CD46', 'NFKBIA', 'TNFSF10', 'IFNA4', 'RCHY1', 'CSNK2A3', 'CD28', 'FAS', 'PRKCQ', 'BBC3', 'IRAK4', 'STAT1', 'RAB9B', 'IFNAR2', 'TNFRSF10C', 'PIK3CG', 'ADAR', 'LOC102723407', 'IL12B', 'CBLB', 'CSNK2B', 'MAVS', 'IL4', 'PIK3R5', 'TRAF6', 'DDX58', 'AKT1', 'TNFRSF10A', 'CCND3', 'CDK4', 'HSPA1L', 'OAS2', 'IL2RG', 'IL2', 'EIF2AK3', 'JAK2', 'IL6', 'EIF2AK1', 'IFNA14', 'FYN', 'TLR2', 'IRF3', 'IFNA17', 'JAK3', 'IKBKE', 'GNB2L1', 'CCNE2', 'PIK3R3', 'JAK1'}, 'Influenza A Homo sapiens hsa05164': {'IRF9', 'TLR4', 'IFNG', 'HLA-DRB3', 'PIK3R1', 'NUP98', 'NXF1', 'IFNA7', 'RAF1', 'AKT3', 'TYK2', 'HLA-DPA1', 'CASP1', 'RNASEL', 'EIF2S1', 'IFNA5', 'MAPK14', 'NXF2B', 'IRF7', 'RELA', 'IFNGR2', 'STAT2', 'PYCARD', 'MAPK11', 'IFNA21', 'CXCL8', 'HSPA2', 'TNF', 'TLR3', 'FASLG', 'PIK3CD', 'GSK3B', 'SLC25A6', 'HLA-DRB4', 'TBK1', 'MAP2K6', 'HLA-DRA', 'HLA-DMA', 'MX1', 'MAPK10', 'TLR7', 'IL12A', 'FURIN', 'IFNA6', 'CCL5', 'NFKBIB', 'MAP2K4', 'TMPRSS13', 'DDX39B', 'AKT2', 'CPSF4', 'IFIH1', 'IFNA1', 'IFNA13', 'IFNA8', 'TICAM1', 'IVNS1ABP', 'IFNA2', 'HSPA1A', 'TNFRSF10D', 'IFNA10', 'HSPA1B', 'EIF2AK4', 'DNAJC3', 'HLA-DPB1', 'TRIM25', 'IFNGR1', 'HLA-DOB', 'MAP2K7', 'EIF2AK2', 'IFNB1', 'PLG', 'CASP9', 'PIK3CB', 'CXCL10', 'KPNA2', 'IKBKB', 'NLRX1', 'IL1A', 'PML', 'IFNA16', 'PRKCB', 'IL1B', 'NLRP3', 'MYD88', 'PRSS1', 'HLA-DRB1', 'MAPK1', 'NXT1', 'NXF3', 'NXF2', 'HSPA8', 'ICAM1', 'PRSS3', 'TNFRSF10B', 'RSAD2', 'PIK3CA', 'XPO1', 'HSPA6', 'OAS3', 'MAPK13', 'HLA-DQA2', 'RAE1', 'NFKB1', 'OAS1', 'PABPN1', 'IFNAR1', 'MAP2K1', 'MAPK8', 'MAP2K3', 'CYCS', 'PIK3R2', 'HLA-DMB', 'AGFG1', 'NXF5', 'NFKBIA', 'HLA-DRB5', 'TNFSF10', 'DNAJB1', 'IFNA4', 'EP300', 'MAPK3', 'JUN', 'FAS', 'HLA-DOA', 'MAPK9', 'PRSS2', 'IRAK4', 'STAT1', 'IFNAR2', 'ACTB', 'TNFRSF10C', 'BCL2L2-PABPN1', 'PIK3CG', 'ATF2', 'ADAR', 'IL33', 'HLA-DQB1', 'IL12B', 'IL18', 'MAVS', 'PIK3R5', 'DDX58', 'AKT1', 'TNFRSF10A', 'VDAC1', 'PABPN1L', 'HNRNPUL1', 'CIITA', 'NXT2', 'HSPA1L', 'KPNA1', 'OAS2', 'MAPK12', 'PRKCA', 'ACTG1', 'MAP2K2', 'EIF2AK3', 'JAK2', 'IL6', 'TMPRSS4', 'TMPRSS2', 'EIF2AK1', 'IFNA14', 'CREBBP', 'IRF3', 'CCL2', 'IFNA17', 'IKBKE', 'SOCS3', 'PIK3R3', 'TNFRSF1A', 'HLA-DQA1', 'JAK1', 'FDPS'}, 'Herpes simplex infection Homo sapiens hsa05168': {'IRF9', 'ALYREF', 'CSNK2A2', 'ARNTL', 'IFIT1', 'IFNG', 'HLA-DRB3', 'CHUK', 'CSNK2A1', 'CD74', 'TRAF5', 'NXF1', 'IFNA7', 'SRSF8', 'TYK2', 'PER3', 'SRSF9', 'HLA-DPA1', 'TBPL2', 'IL15', 'TAF5', 'RNASEL', 'TRAF2', 'TAP1', 'EIF2S1', 'SKP2', 'LTA', 'IFNA5', 'GLTSCR2', 'NXF2B', 'IRF7', 'RELA', 'TBP', 'IFNGR2', 'STAT2', 'HCFC2', 'IFNA21', 'CDK2', 'TAF6', 'CUL1', 'TNF', 'TLR3', 'FASLG', 'SRSF7', 'PPP1CA', 'HLA-C', 'HLA-DRB4', 'TBK1', 'CFP', 'HLA-DRA', 'POU2F3', 'TAB1', 'HLA-DMA', 'PPP1CC', 'MAPK10', 'TAF4', 'IL12A', 'CASP8', 'PER1', 'IFNA6', 'CCL5', 'NFKBIB', 'PTPN11', 'IFIH1', 'IFNA1', 'IFNA13', 'TAP2', 'HLA-B', 'IFNA8', 'TICAM1', 'SP100', 'IFNA2', 'IFNA10', 'HNRNPK', 'HLA-F', 'EIF2AK4', 'HLA-DPB1', 'IFNGR1', 'HLA-DOB', 'EIF2AK2', 'TAB2', 'CDC34', 'IFNB1', 'SRSF2', 'IKBKB', 'MED8', 'MAP3K7', 'FADD', 'TLR9', 'PML', 'TP53', 'HCFC1', 'IFIT1B', 'TAF4B', 'TAF3', 'TAF6L', 'IFNA16', 'HLA-G', 'GTF2IRD1', 'IL1B', 'USP7', 'TRAF3', 'CLOCK', 'MYD88', 'HLA-DRB1', 'TNFSF14', 'PILRA', 'NXF3', 'NXF2', 'SRSF5', 'C5', 'SRSF3', 'TBPL1', 'UBE2R2', 'MCRS1', 'OAS3', 'HLA-DQA2', 'NFKB1', 'SRSF1', 'OAS1', 'IFNAR1', 'SRSF4', 'MAPK8', 'CYCS', 'HLA-DMB', 'CDK1', 'HLA-E', 'NXF5', 'NFKBIA', 'HLA-DRB5', 'IFNA4', 'PVRL1', 'EP300', 'C3', 'PER2', 'CSNK2A3', 'SRPK1', 'HLA-A', 'JUN', 'FAS', 'HLA-DOA', 'MAPK9', 'TAF10', 'STAT1', 'HMGN1', 'GTF2I', 'IFNAR2', 'PPP1CB', 'HLA-DQB1', 'SKP1', 'IL12B', 'CSNK2B', 'FOS', 'MAVS', 'TRAF6', 'DDX58', 'C1QBP', 'SRSF6', 'OAS2', 'CASP3', 'POLR2A', 'EIF2AK3', 'JAK2', 'IL6', 'EIF2AK1', 'TRAF1', 'IFNA14', 'TLR2', 'CREBBP', 'IRF3', 'TNFRSF14', 'EEF1D', 'IKBKG', 'CCL2', 'IFNA17', 'DAXX', 'IKBKE', 'TAF5L', 'TAF9B', 'TAF13', 'SOCS3', 'PVRL2', 'TNFRSF1A', 'HLA-DQA1', 'JAK1'}, 'Epstein-Barr virus infection Homo sapiens hsa05169': {'PSMD6', 'CSNK2A2', 'IFNG', 'HLA-DRB3', 'CHUK', 'CSNK2A1', 'YWHAQ', 'PIK3R1', 'TRAF5', 'POLR2E', 'RBPJ', 'AKT3', 'NUP214', 'TYK2', 'SNW1', 'TBPL2', 'PTMA', 'CD44', 'TRAF2', 'SKP2', 'MAPK14', 'PSMD3', 'POLR3H', 'PSMD2', 'RELA', 'MAP3K14', 'TBP', 'CCNA2', 'FGR', 'PLCG1', 'POLR2C', 'MAPK11', 'STAT3', 'CD58', 'HSPA2', 'CDK2', 'PIK3CD', 'GSK3B', 'HLA-C', 'NEDD4', 'HLA-DRB4', 'TBK1', 'MAP2K6', 'HLA-DRA', 'TAB1', 'HDAC1', 'HDAC4', 'POLR2D', 'LOC101060521', 'MAPK10', 'PSMD14', 'PSMC3', 'NFKBIB', 'YWHAG', 'MAP2K4', 'TNFAIP3', 'AKT2', 'YWHAB', 'POLR2J', 'PLCG2', 'PSMD13', 'GTF2B', 'IRAK1', 'HLA-B', 'CDKN1B', 'NFKBIE', 'PSMC6', 'CR2', 'POLR3B', 'POLR2K', 'POLR2L', 'CCNA1', 'HSPA1A', 'HLA-F', 'HSPA1B', 'HLA-DPB1', 'EIF2AK4', 'YWHAE', 'PSMC2', 'PSMC5', 'IL10RB', 'POLR1C', 'POLR1D', 'POLR3A', 'POLR2I', 'CD38', 'MAP2K7', 'EIF2AK2', 'TAB2', 'PIK3CB', 'IKBKB', 'MAP3K7', 'PSMD12', 'RAN', 'TP53', 'MDM2', 'POLR3K', 'HLA-G', 'POLR2H', 'RBPJL', 'USP7', 'TRAF3', 'HLA-DRB1', 'RELB', 'POLR3C', 'POLR3GL', 'HDAC5', 'HSPA8', 'ICAM1', 'PIK3CA', 'XPO1', 'ENTPD8', 'HSPA6', 'TBPL1', 'MAPK13', 'HLA-DQA2', 'NFKB1', 'MAPK8', 'PSMD8', 'POLR3E', 'MAP2K3', 'PIK3R2', 'HDAC2', 'CDK1', 'PSMC4', 'HLA-E', 'NFKBIA', 'HLA-DRB5', 'EP300', 'HSPB2', 'RB1', 'POLR2J3', 'CSNK2A3', 'YWHAZ', 'HLA-A', 'JUN', 'MAPK9', 'NCOR2', 'SPN', 'POLR3D', 'ENTPD3', 'SND1', 'IL10', 'LYN', 'GTF2E1', 'PIK3CG', 'ATF2', 'POLR2J2', 'POLR3G', 'HLA-DQB1', 'SPI1', 'LOC102723407', 'PSMD11', 'POLR3F', 'CSNK2B', 'PSMD1', 'CD19', 'PIK3R5', 'ENTPD1', 'TRAF6', 'TRADD', 'PSMD4', 'AKT1', 'DDX58', 'BCL2', 'SYK', 'PRKACA', 'IL10RA', 'GTF2E2', 'FCER2', 'HSPA1L', 'PRKACG', 'HSPB1', 'MAPK12', 'RIPK1', 'VIM', 'POLR2F', 'PSMC1', 'POLR2A', 'ITGAL', 'NFKB2', 'EIF2AK3', 'EIF2AK1', 'TRAF1', 'MYC', 'CREBBP', 'IRF3', 'IKBKG', 'AKAP8L', 'POLR2B', 'JAK3', 'CD40', 'PSMD7', 'YWHAH', 'SHFM1', 'PRKACB', 'PIK3R3', 'HLA-DPA1', 'HLA-DQA1', 'JAK1', 'POLR2G', 'CDKN1A'}, 'Viral carcinogenesis Homo sapiens hsa05203': {'IRF9', 'UBR4', 'DDB1', 'HIST1H4C', 'STAT5B', 'BAK1', 'HIST2H2BE', 'YWHAQ', 'PIK3R1', 'TRAF5', 'VAC14', 'RBPJ', 'EGR3', 'CREB3L4', 'SNW1', 'TBPL2', 'RBL2', 'TRAF2', 'SKP2', 'IRF7', 'CHD4', 'CDKN2B', 'RELA', 'TBP', 'CCNA2', 'CCND1', 'STAT3', 'GTF2H2C_2', 'CDK2', 'PMAIP1', 'HIST1H4L', 'CDKN1A', 'CCND2', 'PIK3CD', 'HIST1H2BC', 'HLA-C', 'DLG1', 'HDAC1', 'HIST2H4B', 'RAC1', 'HDAC4', 'RASA2', 'EGR2', 'CASP8', 'HIST1H2BD', 'RHOA', 'H2BFWT', 'MAPKAPK2', 'ACTN4', 'YWHAG', 'GTF2A2', 'CDC42', 'CREB3L1', 'HIST2H4A', 'GTF2A1', 'YWHAB', 'GTF2H2C', 'GTF2B', 'HIST1H2BJ', 'STAT5A', 'HLA-B', 'CDKN1B', 'SP100', 'HIST1H2BK', 'CDK6', 'CCNA1', 'HNRNPK', 'HLA-F', 'HIST4H4', 'YWHAE', 'GRB2', 'HIST1H2BB', 'HDAC8', 'POLB', 'ACTN2', 'EIF2AK2', 'KAT2A', 'PIK3CB', 'CCR4', 'KRAS', 'CCR8', 'CCNE1', 'HIST1H4A', 'HIST1H2BN', 'GSN', 'HDAC11', 'DNAJA3', 'HIST1H4J', 'TP53', 'MDM2', 'HIST1H4D', 'GTF2H3', 'HLA-G', 'HIST1H2BH', 'CCR3', 'RBPJL', 'MAD1L1', 'USP7', 'TRAF3', 'HIST1H2BA', 'GTF2H4', 'MAPK1', 'HIST1H4G', 'HIST1H2BE', 'VDAC3', 'HDAC5', 'HIST1H2BO', 'PIK3CA', 'TBPL1', 'BAX', 'CDKN2A', 'NFKB1', 'ATF4', 'HIST1H4K', 'HIST2H2BF', 'HIST1H4B', 'PKM', 'PIK3R2', 'GTF2H2', 'CREB5', 'HIST1H2BL', 'HDAC2', 'CDK1', 'HLA-E', 'NFKBIA', 'HDAC7', 'GTF2H1', 'EP300', 'C3', 'SRC', 'HIST1H4I', 'RB1', 'UBE3A', 'YWHAZ', 'MAPK3', 'HLA-A', 'ACTN3', 'JUN', 'HIST1H2BM', 'CDC20', 'ATP6V0D2', 'KAT2B', 'GTF2A1L', 'SND1', 'LYN', 'RANBP1', 'HIST1H2BI', 'CREB1', 'JAK1', 'GTF2E1', 'PIK3CG', 'ATF2', 'HIST1H4E', 'HIST1H2BF', 'BAD', 'HDAC6', 'HRAS', 'H2BFM', 'PIK3R5', 'ACTN1', 'REL', 'SCRIB', 'TRADD', 'DDX3X', 'CCND3', 'HIST1H4H', 'HIST1H4F', 'SYK', 'CHEK1', 'PRKACA', 'HPN', 'CDK4', 'SRF', 'GTF2E2', 'NRAS', 'CREB3', 'HDAC3', 'PRKACG', 'CASP3', 'HDAC9', 'HDAC10', 'CREB3L2', 'PSMC1', 'IL6ST', 'NFKB2', 'TRAF1', 'CREBBP', 'IRF3', 'IKBKG', 'ATF6B', 'LTBR', 'MRPS18B', 'HIST3H2BB', 'JAK3', 'PXN', 'SCIN', 'HIST1H2BG', 'YWHAH', 'RBL1', 'CCNE2', 'PRKACB', 'ATP6V0D1', 'PIK3R3', 'CCR5', 'CREB3L3'}, 'MicroRNAs in cancer Homo sapiens hsa05206': {'NOTCH3', 'TPM1', 'MIR200B', 'TNXB', 'MIR193B', 'CDC25A', 'MIR214', 'MIR331', 'BAK1', 'MIR92A2', 'CYP1B1', 'SLC45A3', 'MIR133B', 'MIR32', 'MIR602', 'RAF1', 'MIR181A1', 'ZEB1', 'MIR345', 'MIR103A2', 'MIR373', 'CD44', 'MIR7-1', 'EZH2', 'BMF', 'MIR124-2', 'MIR200C', 'MIR520C', 'UBE2I', 'ABCB1', 'MIR326', 'MIR10B', 'MIR215', 'PTEN', 'MIR125A', 'HOXD10', 'DNMT3A', 'MIR16-1', 'MIR23B', 'MIR203B', 'PLCG1', 'BCL2L11', 'CCND1', 'MIRLET7D', 'MIR26A1', 'MIR223', 'MTOR', 'STAT3', 'VEGFA', 'MIR129-1', 'NOTCH2', 'SPRY2', 'SHC4', 'NOTCH1', 'MIR199B', 'MIR19A', 'CCND2', 'MIR23A', 'SIRT1', 'HMOX1', 'MIRLET7E', 'STMN1', 'CYP24A1', 'TNR', 'APC', 'MIR15B', 'HDAC4', 'MIR17', 'HDAC1', 'MIR192', 'EZR', 'SOS2', 'PRKCE', 'MIR126', 'MIR101-2', 'MIR30B', 'MIR125B2', 'MIRLET7F1', 'MIR335', 'MIR29C', 'SOS1', 'MIR363', 'MIR29A', 'RHOA', 'MIR146A', 'MIR1-1', 'THBS1', 'RDX', 'MIR483', 'PLCG2', 'MIR30A', 'MIR92A1', 'GLS', 'MIR494', 'MIR449A', 'CDKN1B', 'FOXP1', 'TGFB2', 'MIR615', 'MIR210', 'MIR30E', 'CDK6', 'MIR15A', 'IGF2BP1', 'MIR27A', 'MIR342', 'HNRNPK', 'MIR194-2', 'E2F3', 'MIR133A2', 'GRB2', 'MIR128-2', 'MIR150', 'ITGB3', 'MIR181D', 'MIR200A', 'MIRLET7G', 'MCL1', 'KRAS', 'IKBKB', 'MIR103A1', 'E2F2', 'ITGA5', 'CCNE1', 'BCL2L2', 'PLAU', 'MARCKS', 'BMI1', 'ST14', 'APC2', 'MIR23C', 'TNC', 'MIR375', 'TP53', 'MDM2', 'MIR103B2', 'MIR129-2', 'CDC25B', 'SOCS1', 'PRKCB', 'CRK', 'MIR330', 'MIR181B1', 'DNMT1', 'MIRLET7B', 'MIR9-2', 'MIR625', 'MIRLET7A2', 'MIR107', 'ZFPM2', 'MAPK1', 'MIR26A2', 'WNT3A', 'MIR21', 'MIR34C', 'PIM1', 'MIR128-1', 'MIR199A1', 'TP63', 'PIK3CA', 'MIR206', 'MMP16', 'MIR199A2', 'ZEB2', 'CDKN2A', 'NFKB1', 'MIR106B', 'ABCC1', 'MIR195', 'MAP2K1', 'MIR101-1', 'MIR29B2', 'TIMP3', 'PIK3R2', 'ERBB3', 'KIF23', 'CDCA5', 'HMGA2', 'MIR7-3', 'MIR18A', 'EP300', 'MIR155', 'MIR122', 'MIR194-1', 'MIR451A', 'RPS6KA5', 'DICER1', 'PTGS2', 'TNN', 'NOTCH4', 'MIR137', 'RPTOR', 'MIR205', 'MIR222', 'MIR145', 'DNMT3B', 'CDC25C', 'MIR9-1', 'MIR7-2', 'MIR16-2', 'COMMD3-BMI1', 'TRIM71', 'ERBB2', 'MIR124-3', 'MIR100', 'MIR20A', 'MIR30D', 'GLS2', 'MIR29B1', 'MIR27B', 'FSCN1', 'EFNA3', 'MIR143', 'MIR224', 'MIR19B2', 'MIR10A', 'MIR152', 'MDM4', 'MIR133A1', 'MIR25', 'CCNG1', 'MMP9', 'BRCA1', 'HRAS', 'MET', 'MIR203A', 'EGFR', 'SHC1', 'MIR30C1', 'MIRLET7A3', 'BCL2', 'MIR103B1', 'MIR423', 'MIR99A', 'MIR324', 'MIR135A1', 'NRAS', 'ATM', 'ABL1', 'MIR1-2', 'ROCK1', 'PDGFA', 'PDGFRB', 'MIR181C', 'MIR520H', 'PDGFB', 'SERPINB5', 'MIR141', 'PRKCA', 'MIR31', 'VIM', 'IRS2', 'CASP3', 'MIR96', 'MIRLET7C', 'SOX4', 'PDCD4', 'MAP2K2', 'MIR19B1', 'FZD3', 'MIR30C2', 'RASSF1', 'MYC', 'MIR34A', 'PAK4', 'MIRLET7F2', 'MIR520A', 'CREBBP', 'MIR520G', 'SLC7A1', 'MIR28', 'DDIT4', 'RECK', 'MAPK7', 'MIR125B1', 'CRKL', 'MIR9-3', 'MIR181A2', 'E2F1', 'MIR135A2', 'IRS1', 'MIRLET7A1', 'WNT3', 'PRKCG', 'CCNE2', 'MIR135B', 'MIR124-1', 'MIR181B2', 'FGFR3', 'MIR26B', 'MIRLET7I', 'BMPR2', 'MIR183', 'MIR221', 'MIR34B', 'PDGFRA', 'CDKN1A'}, 'Bladder cancer Homo sapiens hsa05219': {'MMP9', 'MAPK1', 'THBS1', 'HRAS', 'EGF', 'RAF1', 'MMP2', 'EGFR', 'DAPK2', 'TYMP', 'CDKN2A', 'CDK4', 'NRAS', 'MAP2K1', 'DAPK1', 'DAPK3', 'E2F3', 'ARAF', 'CCND1', 'MAP2K2', 'CXCL8', 'RPS6KA5', 'CDH1', 'RASSF1', 'MYC', 'MMP1', 'VEGFA', 'SRC', 'KRAS', 'RB1', 'MAPK3', 'E2F2', 'UPK3A', 'HBEGF', 'E2F1', 'TP53', 'BRAF', 'FGFR3', 'MDM2', 'ERBB2', 'CDKN1A'}, 'Thyroid cancer Homo sapiens hsa05216': {'TCF7', 'TCF7L1', 'MAPK1', 'HRAS', 'LEF1', 'PAX8', 'TCF7L2', 'TFG', 'NRAS', 'MAP2K1', 'CCND1', 'RXRA', 'MAP2K2', 'CDH1', 'TPM3', 'MYC', 'RXRG', 'KRAS', 'MAPK3', 'RXRB', 'RET', 'CCDC6', 'NTRK1', 'TPR', 'NCOA4', 'TP53', 'BRAF', 'CTNNB1', 'PPARG'}, 'Dorso-ventral axis formation Homo sapiens hsa04320': {'NOTCH3', 'SOS1', 'CPEB2', 'CPEB1', 'SPIRE2', 'MAPK1', 'ETS2', 'ETV6', 'PIWIL4', 'ETS1', 'EGFR', 'CPEB4', 'MAP2K1', 'PIWIL2', 'GRB2', 'SPIRE1', 'ETV7', 'PIWIL1', 'NOTCH4', 'NOTCH2', 'KRAS', 'MAPK3', 'NOTCH1', 'PIWIL3', 'FMN2', 'CPEB3', 'SOS2'}, 'TGF-beta signaling pathway Homo sapiens hsa04350': {'BMP5', 'PITX2', 'IFNG', 'ZFYVE9', 'SMAD9', 'BMP2', 'CHRD', 'RBX1', 'INHBB', 'SMAD1', 'NBL1', 'CDKN2B', 'BMP8A', 'BMPR1A', 'ACVR1', 'CUL1', 'ID4', 'TNF', 'AMHR2', 'SMURF1', 'SMAD6', 'RPS6KB1', 'NOG', 'PPP2R1B', 'LEFTY1', 'E2F5', 'RHOA', 'PPP2CB', 'THBS1', 'PPP2CA', 'TFDP1', 'ZFYVE16', 'ACVR1B', 'INHBE', 'TGFB2', 'LTBP1', 'TGFB1', 'ACVR1C', 'SMAD2', 'GDF7', 'ACVR2B', 'AMH', 'DCN', 'PPP2R1A', 'ID1', 'FST', 'BMP4', 'ID3', 'SMAD4', 'MAPK1', 'BMPR1B', 'GDF6', 'INHBC', 'EP300', 'MAPK3', 'SMAD5', 'SMAD7', 'INHBA', 'GDF5', 'NODAL', 'TGFBR1', 'SKP1', 'TGIF2', 'ACVR2A', 'BMP6', 'ROCK1', 'MINOS1-NBL1', 'TGIF1', 'RPS6KB2', 'BAMBI', 'E2F4', 'BMP8B', 'ID2', 'SP1', 'MYC', 'TGFBR2', 'LEFTY2', 'CREBBP', 'TGFB3', 'SMURF2', 'BMP7', 'RBL1', 'BMPR2', 'SMAD3'}, 'Hippo signaling pathway Homo sapiens hsa04390': {'TCF7', 'WWC1', 'BMP5', 'TCF7L1', 'BMP2', 'WNT8B', 'WNT5A', 'YWHAQ', 'FZD7', 'LLGL2', 'TP73', 'LEF1', 'PARD6G', 'SMAD1', 'FBXW11', 'FZD9', 'STK3', 'BMP8A', 'BMPR1A', 'FZD1', 'CCND1', 'PPP2R2C', 'CDH1', 'NKD1', 'PRKCI', 'WNT9B', 'CCND2', 'RASSF6', 'GSK3B', 'PPP1CA', 'DLG1', 'PPP2R1B', 'CTNNB1', 'APC', 'PPP1CC', 'LLGL1', 'WNT2B', 'LATS2', 'YAP1', 'WNT11', 'AJUBA', 'YWHAG', 'WNT4', 'BTRC', 'FRMD6', 'PPP2CB', 'YWHAB', 'PPP2CA', 'CSNK1E', 'SOX2', 'TCF7L2', 'WNT5B', 'TGFB2', 'CTGF', 'FZD8', 'WNT7B', 'BIRC5', 'TGFB1', 'AXIN1', 'SERPINE1', 'YWHAE', 'PPP2R2B', 'DVL1', 'SMAD2', 'GDF7', 'DLG3', 'DVL3', 'PRKCZ', 'SAV1', 'AMH', 'PARD6B', 'MOB1A', 'CSNK1D', 'PPP2R1A', 'GLI2', 'ID1', 'AFP', 'FRMD1', 'APC2', 'PARD3', 'BMP4', 'BIRC2', 'SMAD4', 'WNT3A', 'CTNNA2', 'WTIP', 'BMPR1B', 'FZD5', 'FZD10', 'MOB1B', 'LIMD1', 'GDF6', 'CTNNA3', 'YWHAZ', 'TEAD1', 'SMAD7', 'PPP2R2A', 'BBC3', 'PARD6A', 'GDF5', 'ACTB', 'WNT6', 'TP53BP2', 'PPP1CB', 'LATS1', 'TGFBR1', 'AMOT', 'FZD4', 'CRB1', 'DLG2', 'FGF1', 'SCRIB', 'DVL2', 'WWTR1', 'MPP5', 'CCND3', 'WNT8A', 'SNAI2', 'FZD6', 'BMP6', 'DLG4', 'AXIN2', 'BMP8B', 'WNT10A', 'CTNNA1', 'TEAD4', 'ACTG1', 'WNT2', 'ID2', 'FZD3', 'RASSF1', 'MYC', 'TGFBR2', 'WNT1', 'TGFB3', 'WNT9A', 'AREG', 'WNT10B', 'TEAD2', 'FZD2', 'CRB2', 'BMP7', 'ITGB2', 'WNT3', 'INADL', 'WNT16', 'NF2', 'YWHAH', 'PPP2R2D', 'BMPR2', 'SMAD3', 'WNT7A', 'TEAD3'}, 'Basal cell carcinoma Homo sapiens hsa05217': {'WNT2B', 'TCF7', 'WNT11', 'TCF7L1', 'FZD4', 'BMP2', 'WNT3A', 'WNT8B', 'WNT5A', 'WNT4', 'FZD7', 'FZD5', 'SMO', 'DVL2', 'LEF1', 'SHH', 'TCF7L2', 'WNT8A', 'FZD10', 'WNT5B', 'FZD8', 'FZD6', 'WNT7B', 'FZD9', 'GLI3', 'AXIN1', 'STK36', 'FZD1', 'AXIN2', 'DVL1', 'WNT10A', 'WNT2', 'GLI1', 'DVL3', 'FZD3', 'WNT1', 'WNT9B', 'WNT9A', 'WNT10B', 'PTCH2', 'FZD2', 'GSK3B', 'GLI2', 'WNT3', 'WNT16', 'APC2', 'PTCH1', 'TP53', 'BMP4', 'CTNNB1', 'APC', 'HHIP', 'SUFU', 'WNT7A', 'WNT6'}, 'Hedgehog signaling pathway Homo sapiens hsa04340': {'WNT2B', 'WNT11', 'WNT3A', 'BMP2', 'ZIC2', 'WNT8B', 'WNT5A', 'BTRC', 'WNT4', 'SMO', 'CSNK1E', 'SHH', 'CSNK1G3', 'WNT8A', 'WNT5B', 'PRKACA', 'FBXW11', 'WNT7B', 'GLI3', 'STK36', 'PRKACG', 'WNT10A', 'GAS1', 'WNT2', 'GLI1', 'LRP2', 'DHH', 'CSNK1A1', 'IHH', 'WNT9B', 'WNT9A', 'WNT1', 'WNT10B', 'PTCH2', 'CSNK1A1L', 'CSNK1D', 'CSNK1G1', 'GLI2', 'GSK3B', 'CSNK1G2', 'WNT3', 'WNT16', 'PTCH1', 'RAB23', 'BMP4', 'PRKACB', 'HHIP', 'SUFU', 'WNT7A', 'WNT6'}, 'Wnt signaling pathway Homo sapiens hsa04310': {'TCF7', 'CSNK2A2', 'TCF7L1', 'LRP5', 'CAMK2D', 'NKD2', 'WNT8B', 'WNT5A', 'CSNK2A1', 'FZD7', 'RBX1', 'LEF1', 'TBL1XR1', 'SOX17', 'CAMK2G', 'CTNNBIP1', 'PPP3CB', 'SFRP5', 'NFATC1', 'FBXW11', 'FZD9', 'FZD1', 'CCND1', 'PPP3R2', 'DKK1', 'PORCN', 'CTBP2', 'NKD1', 'CER1', 'CUL1', 'CSNK1A1', 'WNT9B', 'CCND2', 'GSK3B', 'DAAM2', 'SENP2', 'CTNNB1', 'DAAM1', 'APC', 'RAC1', 'MAPK10', 'WNT2B', 'SIAH1', 'WNT11', 'NOTUM', 'RHOA', 'WNT4', 'BTRC', 'CACYBP', 'CSNK1E', 'TCF7L2', 'CXXC4', 'WNT5B', 'PPP3CC', 'FZD8', 'WNT7B', 'GPC4', 'FRAT2', 'AXIN1', 'SFRP1', 'PLCB1', 'DVL1', 'CAMK2B', 'NLK', 'DVL3', 'DKK4', 'MAP3K7', 'CSNK1A1L', 'PLCB4', 'DKK2', 'RUVBL1', 'APC2', 'TP53', 'TBL1X', 'TBL1Y', 'PRKCB', 'SMAD4', 'WNT3A', 'PRICKLE1', 'FZD5', 'PLCB2', 'SFRP4', 'FZD10', 'SFRP2', 'MAPK8', 'NFATC2', 'EP300', 'CSNK2A3', 'CAMK2A', 'FOSL1', 'LRP6', 'JUN', 'PPP3R1', 'CHD8', 'MAPK9', 'PPARD', 'PPP3CA', 'WNT6', 'PLCB3', 'PSEN1', 'NFATC4', 'FRAT1', 'SKP1', 'FZD4', 'PRICKLE2', 'CSNK2B', 'WIF1', 'RAC3', 'RAC2', 'ROCK2', 'WNT7A', 'DVL2', 'CCND3', 'WNT8A', 'PRKACA', 'FZD6', 'INVS', 'SOST', 'VANGL1', 'MMP7', 'SERPINF1', 'PRKACG', 'AXIN2', 'BAMBI', 'PRKCA', 'WNT10A', 'WNT2', 'FZD3', 'MYC', 'CREBBP', 'WNT1', 'WNT9A', 'WNT10B', 'NFATC3', 'FZD2', 'VANGL2', 'WNT3', 'WNT16', 'PRKCG', 'PRKACB', 'SMAD3', 'CTBP1'}, 'Melanogenesis Homo sapiens hsa04916': {'TCF7', 'ADCY9', 'ADCY3', 'TCF7L1', 'CAMK2D', 'ADCY6', 'WNT8B', 'WNT5A', 'FZD7', 'RAF1', 'CREB3L4', 'LEF1', 'CAMK2G', 'FZD9', 'GNAI1', 'FZD1', 'CALM1', 'WNT9B', 'GNAO1', 'ADCY7', 'GSK3B', 'CTNNB1', 'CALML6', 'WNT2B', 'WNT11', 'WNT4', 'CREB3L1', 'TCF7L2', 'WNT5B', 'FZD8', 'WNT7B', 'PLCB1', 'DVL1', 'CAMK2B', 'CALML3', 'KIT', 'DVL3', 'KRAS', 'ADCY4', 'MC1R', 'PLCB4', 'PRKCB', 'CALM2', 'EDNRB', 'MAPK1', 'WNT3A', 'FZD5', 'PLCB2', 'GNAI2', 'ADCY2', 'ADCY8', 'FZD10', 'MAP2K1', 'TYRP1', 'ADCY5', 'EP300', 'MAPK3', 'CALM3', 'CAMK2A', 'DCT', 'GNAQ', 'CREB1', 'WNT6', 'TYR', 'ADCY1', 'POMC', 'PLCB3', 'MITF', 'FZD4', 'EDN1', 'HRAS', 'DVL2', 'WNT8A', 'PRKACA', 'FZD6', 'NRAS', 'CREB3', 'PRKACG', 'PRKCA', 'WNT10A', 'CREB3L2', 'KITLG', 'WNT2', 'MAP2K2', 'FZD3', 'CREBBP', 'WNT1', 'WNT9A', 'WNT10B', 'FZD2', 'GNAI3', 'ASIP', 'WNT3', 'WNT16', 'PRKCG', 'GNAS', 'PRKACB', 'WNT7A', 'CALML5', 'CREB3L3'}, 'Proteoglycans in cancer Homo sapiens hsa05205': {'IGF1R', 'TLR4', 'DDX5', 'FLNC', 'CAMK2D', 'TIAM1', 'CAV3', 'WNT8B', 'WNT5A', 'SDC2', 'FZD7', 'PIK3R1', 'FN1', 'FGFR1', 'AKT3', 'RAF1', 'MMP2', 'CAMK2G', 'CD44', 'FZD9', 'TFAP4', 'LUM', 'MAPK14', 'MIR10B', 'HOXD10', 'ARAF', 'FZD1', 'PLCG1', 'CCND1', 'MTOR', 'ITPR3', 'MAPK11', 'STAT3', 'ITGA2', 'VEGFA', 'TNF', 'ITPR2', 'WNT9B', 'FGF2', 'FASLG', 'PIK3CD', 'RPS6KB1', 'PPP1CA', 'HBEGF', 'ITGAV', 'BRAF', 'CTNNB1', 'RAC1', 'PPP1CC', 'EZR', 'CD63', 'SOS2', 'ITGB5', 'WNT2B', 'WNT11', 'RPS6', 'SOS1', 'FRS2', 'RHOA', 'CDC42', 'PTPN11', 'DROSHA', 'WNT4', 'EIF4B', 'THBS1', 'ERBB4', 'RDX', 'AKT2', 'HPSE', 'PLCG2', 'ESR1', 'CTSL', 'WNT5B', 'FZD8', 'TGFB2', 'TWIST1', 'VAV2', 'WNT7B', 'TGFB1', 'ANK1', 'GRB2', 'ITPR1', 'CAMK2B', 'ITGB3', 'SMAD2', 'KDR', 'HCLS1', 'PIK3CB', 'DCN', 'KRAS', 'COL21A1', 'GPC3', 'ITGA5', 'PDPK1', 'PLAU', 'IQGAP1', 'ANK3', 'GAB1', 'TWIST2', 'FLNB', 'PTCH1', 'TP53', 'MDM2', 'IGF2', 'PRKCB', 'ARHGEF1', 'HGF', 'ELK1', 'CBLC', 'MAPK1', 'WNT3A', 'MIR21', 'ANK2', 'FZD5', 'CAV1', 'PPP1R12C', 'PIK3CA', 'MRAS', 'MAPK13', 'VTN', 'FZD10', 'MSN', 'CBL', 'MAP2K1', 'PIK3R2', 'TIMP3', 'HIF1A', 'ERBB3', 'ITGB1', 'PLCE1', 'RRAS2', 'SRC', 'HSPB2', 'SLC9A1', 'PLAUR', 'ARHGEF12', 'NANOG', 'CAMK2A', 'MAPK3', 'SDC4', 'FAS', 'HSPG2', 'HPSE2', 'SDC1', 'ERBB2', 'GPC1', 'ACTB', 'WNT6', 'PIK3CG', 'PPP1R12A', 'PPP1CB', 'MIR10A', 'MMP9', 'FZD4', 'CBLB', 'IL12B', 'PTK2', 'ROCK2', 'HRAS', 'PIK3R5', 'SMO', 'MET', 'EGFR', 'AKT1', 'WNT8A', 'CAV2', 'NUDT16L1', 'PRKACA', 'FZD6', 'NRAS', 'ROCK1', 'PTPN6', 'PRKACG', 'RPS6KB2', 'CASP3', 'MAPK12', 'PRKCA', 'WNT10A', 'CTTN', 'ACTG1', 'PDCD4', 'MAP2K2', 'WNT2', 'FZD3', 'MYC', 'PAK1', 'TLR2', 'WNT1', 'WNT9A', 'WNT10B', 'FZD2', 'PXN', 'PPP1R12B', 'IGF1', 'WNT16', 'WNT3', 'RRAS', 'PRKCG', 'FLNA', 'PRKACB', 'PIK3R3', 'WNT7A', 'CDKN1A'}, 'Signaling pathways regulating pluripotency of stem cells Homo sapiens hsa04550': {'IGF1R', 'SMAD9', 'BMP2', 'WNT8B', 'WNT5A', 'FZD7', 'PIK3R1', 'FGFR1', 'RAF1', 'AKT3', 'INHBB', 'SMAD1', 'SKIL', 'FZD9', 'MAPK14', 'BMPR1A', 'FZD1', 'ONECUT1', 'MAPK11', 'STAT3', 'ACVR1', 'MYF5', 'ID4', 'FGF2', 'WNT9B', 'PIK3CD', 'GSK3B', 'PCGF6', 'LHX5', 'CTNNB1', 'APC', 'DUSP9', 'WNT2B', 'WNT11', 'JARID2', 'HAND1', 'WNT4', 'AKT2', 'SOX2', 'PCGF2', 'ACVR1B', 'TBX3', 'PCGF1', 'WNT5B', 'INHBE', 'FZD8', 'REST', 'FGFR2', 'WNT7B', 'ISL1', 'AXIN1', 'ACVR1C', 'GRB2', 'LIF', 'TCF3', 'DVL1', 'SMAD2', 'KLF4', 'POU5F1', 'DVL3', 'ACVR2B', 'PIK3CB', 'PAX6', 'KRAS', 'ID1', 'ESRRB', 'BMI1', 'APC2', 'RIF1', 'BMP4', 'MEIS1', 'ID3', 'NEUROG1', 'SMAD4', 'MAPK1', 'WNT3A', 'SMARCAD1', 'BMPR1B', 'FZD5', 'ZIC3', 'POU5F1B', 'PIK3CA', 'MAPK13', 'SETDB1', 'FZD10', 'MAP2K1', 'INHBC', 'PIK3R2', 'HNF1A', 'ZFHX3', 'MAPK3', 'NANOG', 'FGFR4', 'SMAD5', 'COMMD3-BMI1', 'INHBA', 'HESX1', 'WNT6', 'PIK3CG', 'NODAL', 'FZD4', 'HOXB1', 'HRAS', 'PIK3R5', 'KAT6A', 'DVL2', 'ACVR2A', 'PCGF5', 'AKT1', 'WNT8A', 'PCGF3', 'FZD6', 'OTX1', 'NRAS', 'DLX5', 'AXIN2', 'MAPK12', 'WNT10A', 'IL6ST', 'WNT2', 'MAP2K2', 'JAK2', 'ID2', 'FZD3', 'MYC', 'LEFTY2', 'WNT1', 'WNT9A', 'WNT10B', 'ESX1', 'FZD2', 'LIFR', 'JAK3', 'WNT3', 'IGF1', 'WNT16', 'FGFR3', 'BMPR2', 'SMAD3', 'PIK3R3', 'JAK1', 'WNT7A'}, 'HTLV-I infection Homo sapiens hsa05166': {'CDC16', 'CDC23', 'ADCY9', 'ADCY3', 'ADCY6', 'STAT5B', 'CRTC1', 'ETS2', 'HLA-DRB3', 'WNT8B', 'WNT5A', 'FZD7', 'PIK3R1', 'CHUK', 'VAC14', 'AKT3', 'POLE3', 'CHEK2', 'TBPL2', 'IL15', 'TLN2', 'PPP3CB', 'NFATC1', 'MSX2', 'FZD9', 'LTA', 'VDAC2', 'MAP3K14', 'TBP', 'CDKN2B', 'RELA', 'FZD1', 'CCND1', 'PPP3R2', 'BUB3', 'CD3E', 'TNF', 'MYBL1', 'WNT9B', 'CALR', 'ADCY7', 'ATR', 'CCND2', 'PIK3CD', 'GSK3B', 'HLA-C', 'SLC25A6', 'HLA-DRB4', 'DLG1', 'CTNNB1', 'HLA-DRA', 'APC', 'HLA-DMA', 'MSX1', 'WNT2B', 'TLN1', 'EGR2', 'WNT11', 'CRTC2', 'MAP2K4', 'WNT4', 'ATF1', 'RANBP3', 'AKT2', 'PTTG1', 'ETS1', 'STAT5A', 'HLA-B', 'WNT5B', 'PPP3CC', 'MYB', 'FZD8', 'TGFB2', 'ANAPC10', 'WNT7B', 'MAP3K1', 'NRP1', 'ELK4', 'TGFB1', 'HLA-F', 'E2F3', 'HLA-DPB1', 'POLB', 'POLE', 'TCF3', 'DVL1', 'SMAD2', 'ANAPC2', 'HLA-DOB', 'DVL3', 'CD3G', 'SLC25A31', 'POLD3', 'POLD4', 'KAT2A', 'PIK3CB', 'KRAS', 'IKBKB', 'ADCY4', 'E2F2', 'IL1R1', 'IL2RB', 'PDGFRA', 'APC2', 'RAN', 'TP53', 'BCL2L1', 'HLA-G', 'ANAPC5', 'ZFP36', 'IL2RA', 'ELK1', 'SMAD4', 'HLA-DRB1', 'LCK', 'TRRAP', 'RELB', 'WNT3A', 'EGR1', 'VDAC3', 'FZD5', 'ICAM1', 'CREM', 'XPO1', 'PIK3CA', 'ADCY2', 'MRAS', 'TBPL1', 'TP53INP1', 'ADCY8', 'BAX', 'FZD10', 'ANAPC11', 'HLA-DQA2', 'ATF4', 'CDKN2A', 'NFKB1', 'SLC25A4', 'SMAD3', 'CDC27', 'PTTG2', 'CD3D', 'TSPO', 'XBP1', 'MAPK8', 'PIK3R2', 'HLA-DMB', 'ANAPC1', 'CANX', 'ADCY5', 'SLC25A5', 'HLA-E', 'NFATC2', 'ATF3', 'HLA-DRB5', 'NFKBIA', 'RRAS2', 'EP300', 'POLD2', 'GPS2', 'RB1', 'HLA-A', 'FOSL1', 'JUN', 'PPP3R1', 'HLA-DOA', 'SLC2A1', 'CDC20', 'ANAPC7', 'KAT2B', 'PPP3CA', 'CDKN2C', 'PCNA', 'RANBP1', 'CREB1', 'ADCY1', 'MAD2L1', 'WNT6', 'ATF2', 'PIK3CG', 'ANAPC4', 'NFATC4', 'HLA-DQB1', 'SPI1', 'TGFBR1', 'FZD4', 'XIAP', 'FOS', 'TNFRSF13C', 'TERT', 'CDC26', 'TNFRSF1A', 'IL15RA', 'HRAS', 'PIK3R5', 'DVL2', 'AKT1', 'VDAC1', 'CCND3', 'WNT8A', 'MAP3K3', 'MYBL2', 'CHEK1', 'FZD6', 'PRKACA', 'CCNB2', 'CDK4', 'SRF', 'BUB1B', 'CRTC3', 'ATM', 'NRAS', 'PDGFA', 'PDGFRB', 'PDGFB', 'PRKACG', 'IL2RG', 'IL2', 'WNT10A', 'IL1R2', 'WNT2', 'ITGAL', 'NFKB2', 'IL6', 'FZD3', 'NFYB', 'MYC', 'TGFBR2', 'POLE4', 'CREBBP', 'TGFB3', 'WNT9A', 'WNT1', 'WNT10B', 'NFATC3', 'IKBKG', 'CSF2', 'FZD2', 'POLE2', 'LTBR', 'JAK3', 'E2F1', 'CD40', 'WNT16', 'WNT3', 'RRAS', 'ITGB2', 'KAT5', 'POLD1', 'PRKACB', 'PIK3R3', 'HLA-DPA1', 'HLA-DQA1', 'JAK1', 'FDPS', 'WNT7A', 'VCAM1', 'CDKN1A'}, 'Progesterone-mediated oocyte maturation Homo sapiens hsa04914': {'CDC16', 'IGF1R', 'CDC23', 'ADCY9', 'ADCY3', 'CDC25A', 'ADCY6', 'PIK3R1', 'RAF1', 'AKT3', 'LOC100996746', 'MAPK14', 'ARAF', 'CCNA2', 'GNAI1', 'PKMYT1', 'MAPK11', 'CDK2', 'HSP90AB1', 'ADCY7', 'PIK3CD', 'BRAF', 'MAPK10', 'RPS6KA6', 'SPDYE4', 'AKT2', 'RPS6KA1', 'SPDYC', 'ANAPC10', 'SPDYE1', 'CCNA1', 'LOC102723555', 'ANAPC2', 'PIK3CB', 'KRAS', 'ADCY4', 'SPDYE2B', 'HSP90AA1', 'SPDYE5', 'SPDYE2', 'CPEB3', 'CDC25B', 'ANAPC5', 'MAD1L1', 'CPEB1', 'MAPK1', 'MOS', 'MAD2L2', 'FZR1', 'PIK3CA', 'GNAI2', 'ADCY2', 'RPS6KA3', 'MAPK13', 'ADCY8', 'ANAPC11', 'PDE3B', 'CDC27', 'MAP2K1', 'MAPK8', 'PIK3R2', 'CCNB3', 'ANAPC1', 'ADCY5', 'CDK1', 'INS', 'MAPK3', 'LOC102723849', 'MAPK9', 'CDC25C', 'ANAPC7', 'RPS6KA2', 'ADCY1', 'MAD2L1', 'PIK3CG', 'ANAPC4', 'CPEB2', 'PGR', 'ANAPC13', 'CDC26', 'PIK3R5', 'AKT1', 'PLK1', 'PRKACA', 'CPEB4', 'CCNB2', 'SPDYE3', 'PRKACG', 'MAPK12', 'SPDYA', 'LOC100505767', 'GNAI3', 'IGF1', 'BUB1', 'SPDYE6', 'PRKACB', 'PIK3R3', 'CCNB1'}, 'Oocyte meiosis Homo sapiens hsa04114': {'CDC16', 'IGF1R', 'CDC23', 'PPP2R5B', 'ADCY9', 'ADCY3', 'CAMK2D', 'ADCY6', 'YWHAQ', 'RBX1', 'CAMK2G', 'PPP3CB', 'LOC100996746', 'FBXW11', 'CALM1', 'PPP3R2', 'SGOL1', 'PKMYT1', 'ITPR3', 'CDK2', 'CUL1', 'ITPR2', 'ADCY7', 'PPP1CA', 'PPP2R1B', 'PPP1CC', 'CALML6', 'RPS6KA6', 'SPDYE4', 'YWHAG', 'BTRC', 'PPP2CB', 'YWHAB', 'PPP2CA', 'RPS6KA1', 'PTTG1', 'PPP3CC', 'SPDYC', 'ANAPC10', 'SPDYE1', 'LOC102723555', 'AURKA', 'YWHAE', 'ITPR1', 'CAMK2B', 'FBXO43', 'ANAPC2', 'CALML3', 'SMC1B', 'SMC1A', 'ADCY4', 'SPDYE2B', 'CCNE1', 'PPP2R1A', 'SPDYE5', 'SLK', 'SPDYE2', 'CPEB3', 'CALM2', 'ANAPC5', 'CPEB1', 'MAPK1', 'MOS', 'MAD2L2', 'ADCY2', 'RPS6KA3', 'ADCY8', 'ANAPC11', 'PPP2R5D', 'CDC27', 'PTTG2', 'MAP2K1', 'ANAPC1', 'REC8', 'ADCY5', 'CDK1', 'PPP2R5C', 'INS', 'PLCZ1', 'YWHAZ', 'CALM3', 'MAPK3', 'CAMK2A', 'LOC102723849', 'PPP2R5A', 'PPP3R1', 'CDC25C', 'CDC20', 'ANAPC7', 'RPS6KA2', 'PPP3CA', 'ADCY1', 'MAD2L1', 'ANAPC4', 'PPP1CB', 'CPEB2', 'SKP1', 'PGR', 'ANAPC13', 'CDC26', 'STAG3', 'PPP2R5E', 'SMC3', 'PLK1', 'PRKACA', 'CPEB4', 'CCNB2', 'ESPL1', 'SPDYE3', 'PRKACG', 'MAPK12', 'SPDYA', 'LOC100505767', 'IGF1', 'AR', 'BUB1', 'YWHAH', 'SPDYE6', 'CCNE2', 'PRKACB', 'FBXO5', 'CALML5', 'CCNB1'}, 'Cell cycle Homo sapiens hsa04110': {'CDC16', 'TFDP2', 'CDC23', 'CDC25A', 'YWHAQ', 'ORC2', 'RBX1', 'CCNH', 'CHEK2', 'RBL2', 'SKP2', 'CDKN2B', 'CCNA2', 'CCND1', 'BUB3', 'PKMYT1', 'GADD45A', 'CDC14A', 'CDK2', 'GADD45G', 'CUL1', 'CDKN1A', 'CCND2', 'ATR', 'MCM2', 'GSK3B', 'WEE2', 'HDAC1', 'E2F5', 'ORC4', 'YWHAG', 'YWHAB', 'PTTG1', 'TFDP1', 'CDKN1B', 'ZBTB17', 'TGFB2', 'ORC3', 'ANAPC10', 'CDK6', 'TGFB1', 'CCNA1', 'E2F3', 'YWHAE', 'SMAD2', 'ANAPC2', 'SMC1B', 'SMC1A', 'ORC6', 'MCM6', 'E2F2', 'CCNE1', 'TP53', 'MDM2', 'CDC25B', 'ANAPC5', 'MAD1L1', 'SMAD4', 'PRKDC', 'CDKN1C', 'MAD2L2', 'MCM5', 'FZR1', 'ANAPC11', 'CDKN2A', 'CDC27', 'PTTG2', 'CDC6', 'RAD21', 'DBF4', 'CCNB3', 'ANAPC1', 'HDAC2', 'CDK1', 'EP300', 'RB1', 'YWHAZ', 'CDC7', 'CDC25C', 'CDC20', 'ANAPC7', 'PCNA', 'CDKN2C', 'MAD2L1', 'SFN', 'TTK', 'ANAPC4', 'MCM4', 'SKP1', 'MCM7', 'ANAPC13', 'ORC5', 'CDC26', 'SMC3', 'CCND3', 'PLK1', 'CHEK1', 'CCNB2', 'STAG2', 'CDK4', 'CDC45', 'BUB1B', 'ESPL1', 'ABL1', 'ATM', 'E2F4', 'GADD45B', 'WEE1', 'MYC', 'CDC14B', 'CREBBP', 'TGFB3', 'CDK7', 'ORC1', 'STAG1', 'E2F1', 'BUB1', 'YWHAH', 'RBL1', 'CCNE2', 'CDKN2D', 'SMAD3', 'MCM3', 'CCNB1'}, 'p53 signaling pathway Homo sapiens hsa04115': {'SFN', 'SIAH1', 'EI24', 'CASP8', 'MDM4', 'CCNG1', 'SESN1', 'CCNG2', 'THBS1', 'TP73', 'CCNB1', 'IGFBP3', 'CHEK2', 'TNFRSF10B', 'RRM2B', 'BID', 'ZMAT3', 'CCND3', 'SESN3', 'BAX', 'GORAB', 'CDKN2A', 'CHEK1', 'RFWD2', 'CCNB2', 'CDK4', 'CDK6', 'PTEN', 'ATM', 'SESN2', 'CYCS', 'SERPINE1', 'SERPINB5', 'CCNB3', 'CASP3', 'CCND1', 'GADD45B', 'CDK1', 'STEAP3', 'BAI1', 'GADD45A', 'CD82', 'CDK2', 'PIDD1', 'RPRM', 'GTSE1', 'GADD45G', 'CASP9', 'RRM2', 'SHISA5', 'PMAIP1', 'RCHY1', 'APAF1', 'ATR', 'TP53I3', 'FAS', 'CCND2', 'CCNE1', 'TSC2', 'PPM1D', 'IGF1', 'TP53', 'BBC3', 'CCNE2', 'MDM2', 'TP53AIP1', 'PERP', 'DDB2', 'CDKN1A'}, 'Ubiquitin mediated proteolysis Homo sapiens hsa04120': {'CDC16', 'KEAP1', 'UBE2M', 'UBOX5', 'CDC23', 'PIAS1', 'TRIP12', 'DDB1', 'ERCC8', 'TRIM32', 'UBE2QL1', 'UBE2Q2', 'RBX1', 'UBE2L6', 'CUL3', 'MID1', 'UBA2', 'FBXW11', 'SKP2', 'UBE2I', 'MGRN1', 'UBA7', 'SAE1', 'PRPF19', 'UBE2G1', 'HERC4', 'CUL1', 'CUL4B', 'UBE2U', 'SMURF1', 'UBE2H', 'KLHL13', 'UBE3C', 'UBE2F', 'UBE2C', 'NEDD4', 'DDB2', 'SIAH1', 'FBXW8', 'PIAS2', 'UBE2D3', 'UBE2L3', 'BTRC', 'UBA1', 'PARK2', 'UBE2E1', 'VHL', 'UBE2B', 'PPIL2', 'UBE2E3', 'ANAPC10', 'RFWD2', 'MAP3K1', 'FBXO2', 'UBE2S', 'UBE4B', 'ANAPC2', 'UBE2D2', 'FBXO4', 'CDC34', 'BIRC7', 'CUL4A', 'UBE2Z', 'TRIM37', 'DET1', 'KLHL9', 'UBE2W', 'SYVN1', 'PML', 'UBE2O', 'MDM2', 'UBE2J1', 'ITCH', 'SOCS1', 'ANAPC5', 'BIRC2', 'CUL2', 'CBLC', 'NHLRC1', 'BIRC3', 'UBE2D1', 'FZR1', 'UBE3B', 'UBE2R2', 'ANAPC11', 'FANCL', 'CBL', 'CDC27', 'UBE2Q1', 'UBE4A', 'AIRE', 'HERC1', 'ANAPC1', 'UBE2E2', 'UBE2J2', 'UBE2G2', 'UBR5', 'UBE3A', 'RCHY1', 'FBXW7', 'HUWE1', 'BIRC6', 'CDC20', 'ANAPC7', 'UBE2NL', 'PIAS3', 'UBE2K', 'UBE2N', 'ANAPC4', 'WWP1', 'SKP1', 'UBE2D4', 'CBLB', 'XIAP', 'ANAPC13', 'RHOBTB1', 'BRCA1', 'CDC26', 'HERC3', 'TRAF6', 'BIRC8', 'UBA6', 'RNF7', 'WWP2', 'UBA3', 'RHOBTB2', 'PIAS4', 'UBE2A', 'TCEB1', 'STUB1', 'CUL5', 'HERC2', 'SMURF2', 'CUL7', 'TCEB2', 'SOCS3', 'NEDD4L'}, 'Axon guidance Homo sapiens hsa04360': {'UNC5D', 'SEMA4B', 'NGEF', 'SLIT1', 'PLXNB1', 'EPHB1', 'EFNB2', 'PPP3CB', 'EPHB6', 'EPHA4', 'GNAI1', 'SEMA3G', 'DPYSL2', 'PPP3R2', 'ROBO2', 'LIMK1', 'NCK1', 'PLXNA3', 'SEMA4C', 'EPHA6', 'CXCL12', 'SLIT3', 'GSK3B', 'ABLIM1', 'NTN1', 'SEMA3C', 'RAC1', 'UNC5B', 'RASA1', 'LIMK2', 'RHOA', 'CDC42', 'CFL1', 'SRGAP3', 'EFNA4', 'EPHA7', 'NTNG2', 'PPP3CC', 'EFNA5', 'PLXNA1', 'RHOD', 'PLXNA2', 'NRP1', 'EPHA2', 'CXCR4', 'PAK6', 'SEMA5A', 'EPHA1', 'NTN3', 'LRRC4C', 'KRAS', 'SRGAP2', 'UNC5C', 'SEMA4A', 'FES', 'DCC', 'MAPK1', 'ABLIM2', 'SEMA6C', 'SEMA6B', 'LRRC4', 'EPHB2', 'EFNA1', 'SEMA3E', 'GNAI2', 'SLIT2', 'NTNG1', 'SEMA4F', 'PLXNB2', 'ITGB1', 'EFNB3', 'NTN4', 'NFATC2', 'PAK2', 'EFNA2', 'NCK2', 'MAPK3', 'RGS3', 'PPP3R1', 'SEMA3B', 'SEMA5B', 'EPHA8', 'SEMA6D', 'UNC5A', 'PPP3CA', 'EPHA5', 'PLXNC1', 'EFNA3', 'CFL2', 'NFATC4', 'CDK5', 'RAC3', 'DPYSL5', 'RAC2', 'PTK2', 'ROCK2', 'HRAS', 'MET', 'EPHA3', 'EFNB1', 'SEMA4D', 'SRGAP1', 'PAK7', 'EPHB3', 'NRAS', 'ABL1', 'ROCK1', 'PLXNB3', 'L1CAM', 'EPHB4', 'SEMA3A', 'SEMA3D', 'ROBO1', 'PAK4', 'PAK1', 'FYN', 'SEMA6A', 'PAK3', 'NFATC3', 'ABLIM3', 'ROBO3', 'GNAI3', 'RND1', 'SEMA3F', 'SEMA4G', 'SEMA7A', 'ARHGEF12'}, 'Endocytosis Homo sapiens hsa04144': {'IGF1R', 'CXCR2', 'CYTH4', 'ZFYVE9', 'IQSEC1', 'VTA1', 'DAB2', 'SMAP1', 'CAV3', 'VPS36', 'GIT2', 'VPS25', 'VPS45', 'CCDC53', 'PARD6G', 'SNF8', 'PSD', 'GIT1', 'ADRBK1', 'CHMP4B', 'VPS29', 'CHMP5', 'CHMP4A', 'RAB4A', 'EPS15L1', 'CAPZA2', 'CLTB', 'SH3GL1', 'WASH1', 'GRK1', 'ZFYVE27', 'VPS37A', 'HSPA2', 'SNX3', 'RAB31', 'CHMP6', 'FOLR2', 'PRKCI', 'ACAP1', 'ARAP2', 'EPN1', 'RABEP1', 'PLD2', 'SMURF1', 'PIP5K1A', 'AP2A2', 'HLA-C', 'NEDD4', 'FAM21C', 'NTRK1', 'VPS37B', 'MVB12A', 'GRK7', 'ARAP3', 'ARPC1A', 'EPS15', 'FOLR4', 'RAB5A', 'CHMP4C', 'SH3GL3', 'RAB8A', 'RHOA', 'CDC42', 'KIF5B', 'SH3KBP1', 'AGAP3', 'AGAP1', 'SH3GLB2', 'AMPH', 'ARFGAP2', 'ARFGAP1', 'ERBB4', 'ARFGAP3', 'RUFY1', 'RAB11FIP1', 'GBF1', 'RAB11FIP5', 'SPG21', 'VPS37D', 'ARFGEF1', 'ZFYVE16', 'ARF5', 'KIAA1033', 'HLA-B', 'TGFB2', 'PIP5K1B', 'SNX12', 'FGFR2', 'CAPZB', 'PIP5K1C', 'HSPA1A', 'VPS26B', 'HLA-F', 'HSPA1B', 'CLTCL1', 'CXCR4', 'TGFB1', 'LDLRAP1', 'CYTH3', 'RAB11B', 'SMAD2', 'KIT', 'PSD2', 'PRKCZ', 'BIN1', 'KDR', 'DNAJC6', 'PARD6B', 'KIAA0196', 'SNX2', 'EEA1', 'PSD3', 'IL2RB', 'WIPF3', 'PDGFRA', 'EHD1', 'PARD3', 'PML', 'TFRC', 'ITCH', 'RAB11FIP4', 'RAB11A', 'MDM2', 'EPN3', 'CHMP3', 'HLA-G', 'ZFYVE20', 'STAMBP', 'ARFGEF2', 'CHMP2A', 'IL2RA', 'CBLC', 'RAB5C', 'SNX5', 'CXCR1', 'CLTA', 'VPS26A', 'HSPA8', 'CAV1', 'IQSEC3', 'ARF3', 'CAPZA3', 'PDCD6IP', 'ARPC4', 'ADRB2', 'EHD3', 'HSPA6', 'ASAP1', 'WAS', 'ASAP2', 'DNM2', 'GRK5', 'CBL', 'VPS4A', 'SH3GLB1', 'ACAP3', 'CHMP7', 'SNX32', 'RAB22A', 'STAM2', 'ARPC2', 'ERBB3', 'KIF5A', 'HLA-E', 'EHD4', 'WIPF2', 'ACAP2', 'PSD4', 'EHD2', 'SRC', 'CYTH1', 'ARRB2', 'HLA-A', 'CLTC', 'LDLR', 'FGFR4', 'RAB11FIP3', 'AP2A1', 'SNX4', 'ASAP3', 'PARD6A', 'IST1', 'WASL', 'RNF41', 'ARPC3', 'EPN2', 'GRK4', 'SPG20', 'ARF6', 'SNX1', 'AP2B1', 'SMAP2', 'RNF103-CHMP3', 'CSF1R', 'WWP1', 'TSG101', 'TGFBR1', 'FOLR1', 'VPS28', 'CBLB', 'WIPF1', 'HRAS', 'KIF5C', 'EGF', 'IQSEC2', 'MET', 'TRAF6', 'EGFR', 'CAV2', 'GRK6', 'VPS37C', 'HGS', 'ARPC5L', 'AGAP2', 'ARPC5', 'VPS4B', 'PLD1', 'DNM1', 'ARRB1', 'ADRB1', 'SH3GL2', 'PIP5KL1', 'HSPA1L', 'RAB5B', 'IL2RG', 'RAB10', 'MVB12B', 'AP2S1', 'STAM', 'USP8', 'ADRB3', 'RAB35', 'CAPZA1', 'F2R', 'TGFBR2', 'AP2M1', 'TGFB3', 'DNM3', 'RAB7A', 'FOLR3', 'RET', 'RAB11FIP2', 'SMURF2', 'IGF2R', 'CHMP2B', 'CYTH2', 'ARAP1', 'ARPC1B', 'FAM21A', 'ARF1', 'CHMP1B', 'FGFR3', 'VPS35', 'FLT1', 'SMAD3', 'CCR5', 'ADRBK2', 'NEDD4L', 'SNX6'}, 'Bacterial invasion of epithelial cells Homo sapiens hsa05100': {'VCL', 'CAV3', 'SEPT1', 'PIK3R1', 'FN1', 'ELMO1', 'SEPT3', 'CLTB', 'CDH1', 'ELMO2', 'SHC4', 'PIK3CD', 'CTNNB1', 'RAC1', 'ARPC1A', 'RHOG', 'RHOA', 'CDC42', 'ELMO3', 'CLTCL1', 'HCLS1', 'PIK3CB', 'SEPT8', 'ITGA5', 'SEPT9', 'GAB1', 'WASF2', 'CBLC', 'ARHGEF26', 'CTNNA2', 'MAD2L2', 'CLTA', 'CAV1', 'DOCK1', 'ARPC4', 'DNM2', 'PIK3CA', 'SEPT6', 'WAS', 'SEPT11', 'CBL', 'CTNNA3', 'BCAR1', 'PIK3R2', 'ARPC2', 'ITGB1', 'CD2AP', 'SRC', 'ILK', 'CLTC', 'SEPT12', 'ARHGAP10', 'WASL', 'ARPC3', 'SHC2', 'ACTB', 'PIK3CG', 'CBLB', 'PTK2', 'PIK3R5', 'MET', 'SHC3', 'SHC1', 'WASF1', 'CAV2', 'ARPC5L', 'ARPC5', 'DNM1', 'SEPT2', 'CTTN', 'CTNNA1', 'ACTG1', 'DNM3', 'CRKL', 'PXN', 'CRK', 'ARPC1B', 'PIK3R3'}, 'Shigellosis Homo sapiens hsa05131': {'WASF2', 'DIAPH1', 'RHOG', 'MAPK1', 'VCL', 'CDC42', 'NFKBIB', 'NOD1', 'CHUK', 'BTRC', 'PFN2', 'ROCK2', 'ELMO3', 'MAD2L2', 'PFN3', 'DOCK1', 'ELMO1', 'ARPC4', 'WASF1', 'WAS', 'MAPK13', 'CD44', 'ATG5', 'U2AF1L4', 'NOD2', 'ARPC5L', 'NFKB1', 'FBXW11', 'ARPC5', 'ABL1', 'MAPK14', 'MAPK8', 'ROCK1', 'RELA', 'ARPC2', 'MAPK12', 'ITGB1', 'CTTN', 'UBE2D2', 'MAPK11', 'NFKBIA', 'CXCL8', 'ACTG1', 'U2AF1', 'ELMO2', 'SRC', 'HCLS1', 'RIPK2', 'MAPK3', 'IKBKB', 'ITGA5', 'IKBKG', 'MAPK9', 'CRKL', 'CRK', 'PFN1', 'PFN4', 'ARPC1B', 'LOC102724594', 'RAC1', 'WASL', 'ARPC3', 'ACTB', 'ARPC1A', 'MAPK10'}, 'Salmonella infection Homo sapiens hsa05132': {'TLR4', 'IFNG', 'FLNC', 'PLEKHM2', 'CASP1', 'CCL4L2', 'MAPK14', 'RELA', 'IFNGR2', 'PYCARD', 'MAPK11', 'KLC3', 'CXCL8', 'RILP', 'RAC1', 'TLR5', 'ARPC1A', 'MAPK10', 'DYNC1LI1', 'RHOG', 'DYNC1I1', 'CDC42', 'CXCL2', 'PFN2', 'MYH14', 'CXCL3', 'DYNC1LI2', 'CCL3L3', 'PKN1', 'PKN2', 'IFNGR1', 'CXCL1', 'NLRC4', 'MYH10', 'FLNB', 'IL1A', 'NOS2', 'WASF2', 'IL1B', 'LBP', 'MYD88', 'MAPK1', 'PFN3', 'ARPC4', 'WAS', 'MAPK13', 'NFKB1', 'MAPK8', 'ARPC2', 'KLC2', 'MAPK3', 'PKN3', 'JUN', 'CD14', 'CCL3L1', 'MAPK9', 'PFN4', 'KLC1', 'WASL', 'ARPC3', 'ACTB', 'IL18', 'FOS', 'ROCK2', 'CCL3', 'DYNC1H1', 'WASF1', 'RAB7B', 'ARPC5L', 'ARPC5', 'MYH9', 'DYNC2H1', 'ROCK1', 'DYNC1I2', 'MAPK12', 'ACTG1', 'IL6', 'CSF2', 'RAB7A', 'KLC4', 'PFN1', 'TJP1', 'ARPC1B', 'FLNA', 'CCL4', 'CCL4L1'}, 'Pathogenic Escherichia coli infection Homo sapiens hsa05130': {'TLR4', 'RHOA', 'TUBB2B', 'TUBB', 'ARHGEF2', 'CDC42', 'TUBB2A', 'YWHAQ', 'ROCK2', 'TUBA3E', 'TUBB4A', 'ARPC4', 'TUBB8', 'TUBB3', 'NCL', 'WAS', 'EZR', 'ARPC5L', 'ARPC5', 'ARPC3', 'TUBAL3', 'ABL1', 'ROCK1', 'LY96', 'ARPC2', 'PRKCA', 'ITGB1', 'KRT18', 'CTTN', 'TUBA1C', 'ACTG1', 'NCK1', 'TUBB1', 'CDH1', 'NCK2', 'TUBA3C', 'HCLS1', 'TUBA1A', 'FYN', 'TUBA8', 'YWHAZ', 'TUBB4B', 'WASL', 'CD14', 'OCLN', 'ARPC1B', 'TUBA1B', 'CTNNB1', 'CLDN1', 'TUBA3D', 'TUBA4A', 'TLR5', 'ACTB', 'ARPC1A', 'TUBB6'}, 'Leukocyte transendothelial migration Homo sapiens hsa04670': {'F11R', 'CLDN7', 'VCL', 'CLDN14', 'PIK3R1', 'RHOH', 'MMP2', 'CLDN4', 'CLDN6', 'CLDN9', 'MAPK14', 'GNAI1', 'PLCG1', 'PTK2B', 'MAPK11', 'ITK', 'CLDN20', 'CXCL12', 'MYL5', 'NOX1', 'PIK3CD', 'PECAM1', 'CLDN15', 'CTNNB1', 'RAP1A', 'RAC1', 'EZR', 'CLDN3', 'RHOA', 'CDC42', 'ACTN4', 'PTPN11', 'ESAM', 'PLCG2', 'VAV2', 'VAV3', 'CYBB', 'NCF4', 'MYL12B', 'ITGA4', 'THY1', 'CXCR4', 'CYBA', 'ACTN2', 'MYL10', 'MYL12A', 'PIK3CB', 'RAP1B', 'TXK', 'CLDN25', 'NCF1', 'CLDN17', 'PRKCB', 'NOX3', 'CTNNA2', 'MYL9', 'ICAM1', 'PIK3CA', 'GNAI2', 'ARHGAP5', 'MAPK13', 'MLLT4', 'MSN', 'CTNNA3', 'BCAR1', 'PIK3R2', 'ITGB1', 'ARHGAP35', 'RASSF5', 'VAV1', 'ACTN3', 'CLDN8', 'CLDN5', 'RAPGEF3', 'ACTB', 'PIK3CG', 'NCF2', 'CLDN23', 'CD99', 'MMP9', 'MYLPF', 'RAC2', 'PTK2', 'ROCK2', 'PIK3R5', 'ACTN1', 'CLDN22', 'CDH5', 'VASP', 'CLDN10', 'CLDN16', 'CLDN19', 'ROCK1', 'JAM3', 'MAPK12', 'PRKCA', 'CTNNA1', 'MYL2', 'ACTG1', 'ITGAL', 'ITGAM', 'SIPA1', 'MYL7', 'CLDN2', 'JAM2', 'CLDN11', 'OCLN', 'GNAI3', 'CLDN24', 'PXN', 'ITGB2', 'CTNND1', 'PRKCG', 'RAPGEF4', 'PIK3R3', 'CLDN1', 'CLDN18', 'VCAM1'}, 'Tight junction Homo sapiens hsa04530': {'F11R', 'CSNK2A2', 'MYH13', 'CLDN7', 'LLGL2', 'CLDN14', 'CSNK2A1', 'EPB41L1', 'SHROOM2', 'AKT3', 'PARD6G', 'CLDN4', 'PRKCD', 'CLDN6', 'CLDN9', 'SHROOM1', 'ASH1L', 'PTEN', 'GNAI1', 'MAGI2', 'VAPA', 'MYH6', 'PPP2R2C', 'CLDN20', 'PRKCI', 'MYL5', 'MYH15', 'MYH7B', 'YBX3', 'CLDN15', 'PPP2R1B', 'CTNNB1', 'TJP2', 'SHROOM4', 'PRKCE', 'LLGL1', 'MYH2', 'IGSF5', 'CLDN3', 'RHOA', 'CDC42', 'ACTN4', 'MYH8', 'PPP2CB', 'SHROOM3', 'AKT2', 'PPP2CA', 'MYH14', 'EPB41', 'MYL12B', 'SYMPK', 'PPP2R2B', 'ACTN2', 'PRKCZ', 'MYL10', 'MYL12A', 'HCLS1', 'KRAS', 'PARD6B', 'PPP2R1A', 'MYH10', 'CLDN25', 'TJP3', 'PARD3', 'CLDN17', 'PRKCB', 'EPB41L2', 'RAB3B', 'CTNNA2', 'MYH7', 'MYL9', 'MYH3', 'MPDZ', 'GNAI2', 'MRAS', 'MLLT4', 'EXOC3', 'YES1', 'CTNNA3', 'AMOTL1', 'RRAS2', 'TJAP1', 'SRC', 'MYH4', 'CSNK2A3', 'ACTN3', 'MAGI3', 'PRKCQ', 'PPP2R2A', 'CGN', 'RAB13', 'CLDN8', 'PARD6A', 'CLDN5', 'ZAK', 'ACTB', 'CRB3', 'MYH11', 'CLDN23', 'MYH1', 'CSNK2B', 'MYLPF', 'PRKCH', 'HRAS', 'ACTN1', 'CLDN22', 'SPTAN1', 'AKT1', 'CASK', 'MPP5', 'CLDN10', 'EXOC4', 'CDK4', 'MYH9', 'NRAS', 'CLDN16', 'CLDN19', 'JAM3', 'PRKCA', 'CTTN', 'MAGI1', 'CTNNA1', 'MYL2', 'ACTG1', 'MYL7', 'CLDN2', 'JAM2', 'CLDN11', 'EPB41L3', 'OCLN', 'GNAI3', 'CLDN24', 'INADL', 'TJP1', 'RRAS', 'PRKCG', 'PPP2R2D', 'CLDN1', 'CLDN18'}, 'Adherens junction Homo sapiens hsa04520': {'ACP1', 'IGF1R', 'TCF7', 'INSR', 'SMAD4', 'TCF7L1', 'PVRL3', 'CSNK2A2', 'LMO7', 'TGFBR1', 'RHOA', 'SORBS1', 'VCL', 'CDC42', 'ACTN4', 'CSNK2B', 'RAC3', 'CTNNA2', 'CSNK2A1', 'MAPK1', 'RAC2', 'ACTN1', 'FGFR1', 'MET', 'PTPRB', 'LEF1', 'EGFR', 'WASF1', 'TCF7L2', 'MLLT4', 'SNAI1', 'WAS', 'SNAI2', 'RAC1', 'BAIAP2', 'YES1', 'WASF3', 'CTNNA3', 'PTPRM', 'PTPN6', 'CTNNA1', 'SMAD2', 'NLK', 'ACTN2', 'ACTG1', 'EP300', 'PVRL1', 'CDH1', 'FARP2', 'TGFBR2', 'SRC', 'FYN', 'MAPK3', 'CREBBP', 'CSNK2A3', 'MAP3K7', 'PTPRF', 'PTPN1', 'ACTN3', 'IQGAP1', 'SSX2IP', 'CTNND1', 'TJP1', 'FER', 'PARD3', 'CTNNB1', 'ERBB2', 'PVRL4', 'PVRL2', 'SMAD3', 'PTPRJ', 'WASL', 'ACTB', 'WASF2'}, 'Arrhythmogenic right ventricular cardiomyopathy (ARVC) Homo sapiens hsa05412': {'ITGB4', 'CACNA2D2', 'TCF7', 'CACNG3', 'TCF7L1', 'ITGB7', 'CACNA1F', 'ITGA3', 'CACNB2', 'ACTN4', 'DSP', 'CTNNA2', 'CACNG8', 'LMNA', 'CDH2', 'ACTN1', 'CACNA1C', 'ITGA1', 'CACNG5', 'LEF1', 'GJA1', 'CACNA2D3', 'TCF7L2', 'SGCG', 'CACNG6', 'SGCD', 'CACNG2', 'CACNA2D4', 'PKP2', 'ITGB8', 'ITGA8', 'DMD', 'CACNB4', 'EMD', 'ITGA9', 'CACNA1S', 'CACNG1', 'CTNNA3', 'ITGA4', 'CACNA2D1', 'JUP', 'ITGB6', 'ITGB1', 'ITGB3', 'DSG2', 'CTNNA1', 'DAG1', 'CACNA1D', 'ACTN2', 'ITGA2', 'ITGA2B', 'ACTG1', 'ITGA6', 'CACNB3', 'ITGA7', 'ITGA11', 'LAMA2', 'ATP2A2', 'SLC8A1', 'DSC2', 'SGCA', 'ITGA5', 'ACTN3', 'CACNB1', 'RYR2', 'ITGAV', 'CTNNB1', 'CACNG4', 'DES', 'SGCB', 'ITGA10', 'ACTB', 'CACNG7', 'ITGB5'}, 'Hypertrophic cardiomyopathy (HCM) Homo sapiens hsa05410': {'ITGB4', 'TPM1', 'CACNG8', 'CACNA2D3', 'CACNG6', 'MYL3', 'CACNA2D4', 'ITGB8', 'ITGA8', 'DMD', 'CACNB4', 'ITGA9', 'CACNA1S', 'CACNG1', 'CACNA2D1', 'MYH6', 'CACNA1D', 'TPM4', 'ITGA2', 'TPM3', 'CACNB3', 'TNF', 'ITGA11', 'ACTC1', 'ITGAV', 'PRKAG1', 'CACNG4', 'PRKAA1', 'TPM2', 'CACNG7', 'ITGB5', 'CACNA2D2', 'CACNG3', 'LMNA', 'PRKAG3', 'CACNG5', 'TNNI3', 'SGCD', 'CACNG2', 'TGFB2', 'EMD', 'TGFB1', 'ITGA4', 'PRKAA2', 'ITGB3', 'DAG1', 'MYBPC3', 'SGCA', 'PRKAB1', 'SLC8A1', 'ITGA5', 'CACNB1', 'ITGB7', 'ITGA3', 'MYH7', 'CACNA1C', 'ITGA1', 'TNNT2', 'ITGB1', 'ITGA2B', 'ITGA6', 'TNNC1', 'LAMA2', 'ATP2A2', 'RYR2', 'TTN', 'DES', 'ITGA10', 'ACTB', 'CACNA1F', 'PRKAG2', 'CACNB2', 'SGCG', 'ITGB6', 'MYL2', 'ACTG1', 'IL6', 'PRKAB2', 'ITGA7', 'TGFB3', 'ACE', 'IGF1', 'SGCB'}, 'Dilated cardiomyopathy Homo sapiens hsa05414': {'ITGB4', 'ADCY9', 'ADCY3', 'TPM1', 'ADCY6', 'CACNG8', 'CACNA2D3', 'CACNG6', 'MYL3', 'CACNA2D4', 'ITGB8', 'ITGA8', 'DMD', 'CACNB4', 'ITGA9', 'CACNA1S', 'CACNG1', 'CACNA2D1', 'MYH6', 'CACNA1D', 'TPM4', 'ITGA2', 'TPM3', 'CACNB3', 'TNF', 'ITGA11', 'ADCY7', 'ACTC1', 'ITGAV', 'CACNG4', 'TPM2', 'CACNG7', 'ITGB5', 'CACNA2D2', 'CACNG3', 'LMNA', 'CACNG5', 'TNNI3', 'SGCD', 'CACNG2', 'TGFB2', 'EMD', 'TGFB1', 'ITGA4', 'PLN', 'ITGB3', 'DAG1', 'MYBPC3', 'SGCA', 'SLC8A1', 'ADCY4', 'ITGA5', 'CACNB1', 'ITGB7', 'ITGA3', 'MYH7', 'CACNA1C', 'ITGA1', 'ADCY2', 'ADCY8', 'TNNT2', 'ITGB1', 'ADCY5', 'ITGA2B', 'ITGA6', 'TNNC1', 'LAMA2', 'ATP2A2', 'RYR2', 'TTN', 'DES', 'ITGA10', 'ACTB', 'ADCY1', 'LOC102723407', 'CACNA1F', 'CACNB2', 'SGCG', 'PRKACA', 'ADRB1', 'PRKACG', 'ITGB6', 'MYL2', 'ACTG1', 'ITGA7', 'TGFB3', 'IGF1', 'GNAS', 'PRKACB', 'SGCB'}, 'Cardiac muscle contraction Homo sapiens hsa04260': {'TPM1', 'CACNG8', 'COX7B2', 'COX1', 'CACNA2D3', 'UQCRC1', 'CACNG6', 'MYL3', 'CACNA2D4', 'UQCRH', 'CACNB4', 'COX2', 'ATP1B1', 'CACNA1S', 'CACNG1', 'CACNA2D1', 'COX4I2', 'MYH6', 'CACNA1D', 'TPM4', 'COX4I1', 'TPM3', 'CACNB3', 'CYTB', 'ACTC1', 'COX7A2L', 'COX3', 'CACNG4', 'TPM2', 'CACNG7', 'CACNA2D2', 'CACNG3', 'UQCRQ', 'FXYD2', 'ATP1A4', 'CACNG5', 'COX6B2', 'TNNI3', 'CACNG2', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'ATP1B2', 'SLC8A1', 'UQCRHL', 'CACNB1', 'COX7C', 'COX6A2', 'COX7A2', 'COX8C', 'MYH7', 'ATP1A2', 'CACNA1C', 'SLC9A6', 'TNNT2', 'COX5A', 'COX7A1', 'COX5B', 'TNNC1', 'SLC9A1', 'ATP2A2', 'RYR2', 'UQCRFS1', 'ATP1A3', 'CACNA1F', 'CACNB2', 'ATP1B4', 'COX7B', 'CYC1', 'COX6B1', 'MYL2', 'COX6C', 'ATP1B3', 'UQCR11', 'COX8A', 'MYL4', 'ATP1A1'}, 'Non-alcoholic fatty liver disease (NAFLD) Homo sapiens hsa04932': {'MAP3K5', 'NDUFB9', 'MLXIP', 'NDUFV3', 'NDUFC2-KCTD14', 'NDUFS2', 'NDUFA6', 'COX7B2', 'PIK3R1', 'COX1', 'ADIPOQ', 'NDUFV2', 'AKT3', 'NDUFA7', 'LEPR', 'UQCRC1', 'TRAF2', 'EIF2S1', 'UQCRH', 'COX2', 'NDUFB8', 'RELA', 'NR1H3', 'NDUFB5', 'BCL2L11', 'SDHB', 'COX4I2', 'CXCL8', 'COX4I1', 'DDIT3', 'TNF', 'CYTB', 'FASLG', 'PIK3CD', 'GSK3B', 'ADIPOR1', 'COX7A2L', 'NDUFV1', 'PRKAG1', 'COX3', 'RAC1', 'PRKAA1', 'GSK3A', 'MAPK10', 'NDUFA5', 'LEP', 'INSR', 'CASP8', 'NDUFB11', 'UQCRQ', 'CDC42', 'AKT2', 'PRKAG3', 'COX6B2', 'PKLR', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'NDUFB7', 'TGFB1', 'NDUFA1', 'PRKAA2', 'NDUFA12', 'CYP2E1', 'RXRA', 'NDUFAB1', 'NDUFC1', 'NDUFS5', 'PIK3CB', 'PRKAB1', 'IKBKB', 'SDHD', 'NDUFB1', 'UQCRHL', 'IL1A', 'MLX', 'COX7C', 'ITCH', 'NDUFC2', 'COX6A2', 'IL1B', 'COX7A2', 'NDUFS8', 'COX8C', 'NDUFS7', 'NDUFA10', 'PIK3CA', 'NDUFB2', 'BID', 'NDUFA8', 'BAX', 'NFKB1', 'ATF4', 'NDUFB3', 'NDUFA4', 'COX5A', 'MAP3K11', 'MAPK8', 'XBP1', 'SDHC', 'CYCS', 'PIK3R2', 'IL6R', 'COX7A1', 'MLXIPL', 'NDUFS6', 'COX5B', 'PPARA', 'INS', 'JUN', 'FAS', 'MAPK9', 'ERN1', 'NDUFS1', 'NDUFA11', 'PIK3CG', 'ADIPOR2', 'UQCRFS1', 'NDUFA4L2', 'PRKAG2', 'NDUFA13', 'NDUFS3', 'PIK3R5', 'NDUFA9', 'CYC1', 'COX7B', 'AKT1', 'NDUFB6', 'NDUFA3', 'CASP3', 'IRS2', 'COX6B1', 'EIF2AK3', 'NDUFS4', 'IL6', 'COX6C', 'PRKAB2', 'CEBPA', 'NDUFA2', 'NDUFB4', 'SREBF1', 'IRS1', 'CASP7', 'UQCR11', 'SOCS3', 'COX8A', 'TNFRSF1A', 'PIK3R3', 'SDHA', 'NDUFB10'}, "Alzheimer's disease Homo sapiens hsa05010": {'NDUFB9', 'NDUFV3', 'NDUFC2-KCTD14', 'NDUFS2', 'NDUFA6', 'COX7B2', 'COX1', 'NDUFV2', 'GRIN2B', 'NDUFA7', 'UQCRC1', 'PPP3CB', 'ATP5J', 'UQCRH', 'COX2', 'NDUFB8', 'CACNA1S', 'APOE', 'NDUFB5', 'APP', 'CALM1', 'SDHB', 'PPP3R2', 'COX4I2', 'CACNA1D', 'ITPR3', 'GRIN1', 'APH1A', 'COX4I1', 'APBB1', 'ADAM10', 'TNF', 'ITPR2', 'CYTB', 'GSK3B', 'MME', 'COX7A2L', 'NDUFV1', 'COX3', 'GAPDH', 'ATP5B', 'CALML6', 'ATP2A3', 'NDUFA5', 'CASP8', 'NDUFB11', 'NAE1', 'CAPN2', 'ATP5G2', 'UQCRQ', 'ATP6', 'LPL', 'RYR3', 'COX6B2', 'BACE2', 'PPP3CC', 'ADAM17', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'NDUFB7', 'CASP12', 'NDUFA1', 'SNCA', 'PLCB1', 'ITPR1', 'NDUFA12', 'CALML3', 'GRIN2A', 'NDUFAB1', 'LRP1', 'NDUFC1', 'NDUFS5', 'CASP9', 'SDHD', 'APAF1', 'NDUFB1', 'FADD', 'UQCRHL', 'PLCB4', 'ATP2A1', 'COX7C', 'NDUFC2', 'COX6A2', 'CALM2', 'ATP5A1', 'IL1B', 'COX7A2', 'NDUFS8', 'MAPT', 'COX8C', 'ATP5G1', 'MAPK1', 'IDE', 'ATP5H', 'NDUFS7', 'ATP5D', 'CACNA1C', 'APH1B', 'PLCB2', 'NDUFA10', 'BID', 'NDUFB2', 'NDUFA8', 'ATP5G3', 'NDUFA4', 'NDUFB3', 'COX5A', 'ATF6', 'ATP5C1', 'SDHC', 'CYCS', 'NOS1', 'COX7A1', 'NDUFS6', 'COX5B', 'ATP5F1', 'MAPK3', 'CALM3', 'ATP2A2', 'FAS', 'PPP3R1', 'GNAQ', 'ERN1', 'PSENEN', 'NDUFS1', 'GRIN2D', 'PPP3CA', 'NDUFA11', 'PLCB3', 'UQCRFS1', 'PSEN1', 'CACNA1F', 'CDK5', 'NDUFA4L2', 'NDUFA13', 'BAD', 'HSD17B10', 'NDUFS3', 'NDUFA9', 'CYC1', 'COX7B', 'NDUFB6', 'ATP8', 'CAPN1', 'CDK5R1', 'NDUFA3', 'CASP3', 'COX6B1', 'NCSTN', 'EIF2AK3', 'NDUFS4', 'COX6C', 'BACE1', 'PSEN2', 'NDUFA2', 'NDUFB4', 'ATP5O', 'GRIN2C', 'CASP7', 'UQCR11', 'COX8A', 'TNFRSF1A', 'SDHA', 'ATP5E', 'CALML5', 'NDUFB10'}, 'Oxidative phosphorylation Homo sapiens hsa00190': {'NDUFB9', 'NDUFV3', 'NDUFC2-KCTD14', 'NDUFS2', 'ATP6V1F', 'NDUFA6', 'COX7B2', 'COX1', 'NDUFV2', 'NDUFA7', 'ND5', 'UQCRC1', 'ATP5J', 'ATP6V1G3', 'UQCRH', 'ATP6V1C2', 'PPA1', 'COX17', 'COX2', 'NDUFB8', 'ATP6V1G1', 'NDUFB5', 'COX4I2', 'SDHB', 'COX4I1', 'ATP6V0C', 'CYTB', 'LHPP', 'ATP6V1G2', 'COX7A2L', 'NDUFV1', 'COX3', 'COX15', 'ATP6V1B2', 'ATP5B', 'NDUFA5', 'NDUFB11', 'ATP5G2', 'UQCRQ', 'ATP6', 'ATP5J2', 'ND1', 'ATP6V1A', 'COX6B2', 'ATP6V1E2', 'ATP4A', 'ATP6V0A2', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'NDUFB7', 'NDUFA1', 'ND4L', 'NDUFA12', 'ATP5E', 'NDUFAB1', 'ND4', 'NDUFC1', 'NDUFS5', 'SDHD', 'NDUFB1', 'UQCRHL', 'ATP6V0E1', 'COX7C', 'NDUFC2', 'COX6A2', 'ATP6V1C1', 'ATP5A1', 'COX7A2', 'NDUFS8', 'COX8C', 'ATP5G1', 'ATP6V1E1', 'ATP5H', 'ATP4B', 'NDUFS7', 'ATP5D', 'NDUFA10', 'NDUFB2', 'NDUFA8', 'ATP6V0A4', 'ATP6V0A1', 'ATP5G3', 'NDUFA4', 'NDUFB3', 'COX5A', 'ATP5C1', 'SDHC', 'ND6', 'COX7A1', 'ATP6V1B1', 'ATP5I', 'ATP6AP1', 'NDUFS6', 'ATP5F1', 'COX5B', 'ATP6V1H', 'ATP6V0B', 'NDUFS1', 'ATP6V0D2', 'NDUFA11', 'UQCRFS1', 'COX10', 'NDUFA4L2', 'NDUFA13', 'COX11', 'NDUFS3', 'NDUFA9', 'CYC1', 'COX7B', 'ND3', 'ATP6V1D', 'NDUFB6', 'ATP8', 'PPA2', 'NDUFA3', 'COX6B1', 'NDUFS4', 'ATP6V0E2', 'ND2', 'COX6C', 'ATP5L', 'TCIRG1', 'NDUFA2', 'NDUFB4', 'ATP5O', 'UQCR11', 'ATP6V0D1', 'COX8A', 'SDHA', 'ATP12A', 'NDUFB10'}, "Parkinson's disease Homo sapiens hsa05012": {'SLC18A2', 'NDUFB9', 'NDUFV3', 'NDUFC2-KCTD14', 'NDUFS2', 'NDUFA6', 'COX7B2', 'COX1', 'NDUFV2', 'UBE2L6', 'ND5', 'NDUFA7', 'UQCRC1', 'ATP5J', 'UQCRH', 'COX2', 'NDUFB8', 'SLC18A1', 'VDAC2', 'NDUFB5', 'GNAI1', 'COX4I2', 'SDHB', 'UBA7', 'ADORA2A', 'COX4I1', 'UBE2G1', 'CYTB', 'SLC25A6', 'COX7A2L', 'NDUFV1', 'COX3', 'ATP5B', 'PARK7', 'NDUFA5', 'NDUFB11', 'ATP5G2', 'GPR37', 'UQCRQ', 'UBE2L3', 'ATP6', 'DRD1', 'ND1', 'UBA1', 'PARK2', 'COX6B2', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'NDUFB7', 'NDUFA1', 'SNCA', 'ND4L', 'NDUFA12', 'NDUFAB1', 'SLC25A31', 'ND4', 'NDUFC1', 'NDUFS5', 'CASP9', 'SDHD', 'APAF1', 'NDUFB1', 'UQCRHL', 'UBE2J1', 'COX7C', 'NDUFC2', 'COX6A2', 'ATP5A1', 'COX7A2', 'NDUFS8', 'COX8C', 'ATP5G1', 'VDAC3', 'ATP5H', 'NDUFS7', 'ATP5D', 'SNCAIP', 'SEPT5', 'TH', 'NDUFA10', 'NDUFB2', 'GNAI2', 'NDUFA8', 'HTRA2', 'ATP5G3', 'SLC25A4', 'NDUFB3', 'NDUFA4', 'COX5A', 'ATP5C1', 'SDHC', 'CYCS', 'ADCY5', 'ND6', 'COX7A1', 'SLC25A5', 'NDUFS6', 'COX5B', 'ATP5F1', 'UBE2J2', 'UBE2G2', 'SLC6A3', 'LRRK2', 'NDUFS1', 'NDUFA11', 'UCHL1', 'UQCRFS1', 'NDUFA4L2', 'NDUFA13', 'PPIF', 'UBB', 'NDUFS3', 'NDUFA9', 'CYC1', 'COX7B', 'ND3', 'VDAC1', 'NDUFB6', 'ATP8', 'PRKACA', 'PINK1', 'NDUFA3', 'PRKACG', 'CASP3', 'COX6B1', 'DRD2', 'NDUFS4', 'ND2', 'COX6C', 'GNAL', 'NDUFA2', 'GNAI3', 'NDUFB4', 'ATP5O', 'UQCR11', 'PRKACB', 'COX8A', 'SDHA', 'ATP5E', 'NDUFB10'}, "Huntington's disease Homo sapiens hsa05016": {'NDUFB9', 'NDUFV3', 'NDUFC2-KCTD14', 'NDUFS2', 'POLR2E', 'NDUFA6', 'COX7B2', 'COX1', 'NDUFV2', 'GRIN2B', 'NDUFA7', 'CREB3L4', 'UQCRC1', 'TBPL2', 'ATP5J', 'UQCRH', 'COX2', 'NDUFB8', 'VDAC2', 'TBP', 'GRM5', 'CLTB', 'NDUFB5', 'DNAH17', 'COX4I2', 'SDHB', 'POLR2C', 'GRIN1', 'COX4I1', 'DCTN2', 'HAP1', 'CYTB', 'PPARGC1A', 'AP2A2', 'SLC25A6', 'COX7A2L', 'NDUFV1', 'DNAL4', 'COX3', 'DNAH9', 'HDAC1', 'ATP5B', 'POLR2D', 'NDUFA5', 'TAF4', 'CASP8', 'NDUFB11', 'ATP5G2', 'DCTN1', 'UQCRQ', 'ATP6', 'CREB3L1', 'GPX1', 'POLR2J', 'COX6B2', 'HTT', 'COX6A1', 'UQCRC2', 'UQCR10', 'UQCRB', 'NDUFB7', 'REST', 'POLR2K', 'POLR2L', 'NDUFA1', 'CLTCL1', 'PLCB1', 'POLR2I', 'DNAH14', 'NDUFA12', 'ITPR1', 'TFAM', 'NDUFAB1', 'SLC25A31', 'NDUFC1', 'NDUFS5', 'CASP9', 'DNAH1', 'SDHD', 'APAF1', 'NDUFB1', 'UQCRHL', 'PLCB4', 'UCP1', 'TP53', 'COX7C', 'NDUFC2', 'TAF4B', 'COX6A2', 'POLR2H', 'ATP5A1', 'BDNF', 'COX7A2', 'NDUFS8', 'COX8C', 'ATP5G1', 'TGM2', 'VDAC3', 'ATP5H', 'CLTA', 'NDUFS7', 'ATP5D', 'DNALI1', 'PLCB2', 'NDUFA10', 'NDUFB2', 'TBPL1', 'NDUFA8', 'BAX', 'ATP5G3', 'COX5A', 'SLC25A4', 'NDUFB3', 'NDUFA4', 'ATP5C1', 'SDHC', 'CYCS', 'CREB5', 'HDAC2', 'DNAI2', 'COX7A1', 'SLC25A5', 'COX5B', 'DNAH10', 'ATP5F1', 'NDUFS6', 'EP300', 'DNAI1', 'SOD2', 'POLR2J3', 'DNAH6', 'CLTC', 'HIP1', 'GNAQ', 'IFT57', 'SIN3A', 'NDUFS1', 'BBC3', 'NDUFA11', 'AP2A1', 'CREB1', 'PLCB3', 'DNAH7', 'UQCRFS1', 'POLR2J2', 'SOD1', 'AP2B1', 'NDUFA4L2', 'DNAH2', 'NDUFA13', 'DNAH3', 'PPIF', 'DNAL1', 'NDUFS3', 'NDUFA9', 'COX7B', 'CYC1', 'DNAH11', 'VDAC1', 'NDUFB6', 'ATP8', 'DNAH8', 'CREB3', 'DLG4', 'NDUFA3', 'CASP3', 'CREB3L2', 'AP2S1', 'COX6B1', 'POLR2F', 'POLR2A', 'NDUFS4', 'SP1', 'COX6C', 'AP2M1', 'CREBBP', 'CREB3L3', 'DNAH12', 'NDUFA2', 'NDUFB4', 'POLR2B', 'ATP5O', 'RCOR1', 'NRF1', 'UQCR11', 'DNAH5', 'COX8A', 'PPARG', 'DCTN4', 'POLR2G', 'SDHA', 'ATP5E', 'NDUFB10'}, 'Metabolic pathways Homo sapiens hsa01100': {'OXSM', 'MTR', 'PYGM', 'ACADS', 'UGT2A1', 'ALDOC', 'SHMT1', 'LTC4S', 'MAT2B', 'PIK3C2B', 'PFKP', 'ENPP7', 'INPP5B', 'DGKG', 'UGDH', 'B3GALT6', 'HPSE', 'UGCG', 'ITPK1', 'UGT1A4', 'COX6A1', 'PLB1', 'INPP5A', 'AMACR', 'NT5E', 'GMPPA', 'EXT1', 'PANK4', 'IDI1', 'MAN2A2', 'GALNT9', 'LPIN2', 'PLA2G4E', 'ALG8', 'B3GNT6', 'ALG1', 'ATP6V1C1', 'GCH1', 'CYP2J2', 'POLR3GL', 'EBP', 'SHMT2', 'LCT', 'LPIN3', 'MTHFD1L', 'NOS1', 'URAD', 'HADH', 'ATP6V1B1', 'ZNRD1', 'MAOB', 'UMPS', 'MOGAT3', 'AOC2', 'GUK1', 'ATP6V0D2', 'CYP8B1', 'CKMT1B', 'HMGCS1', 'NT5M', 'GALNT5', 'AKR1C4', 'ACOT4', 'STT3A', 'ALG13', 'ACAD8', 'DLD', 'ALPP', 'AHCYL1', 'IDH2', 'CKMT1A', 'TCIRG1', 'DTYMK', 'HSD17B12', 'XYLT2', 'UGT1A7', 'FDPS', 'FPGT', 'ACSL5', 'PNLIPRP3', 'GADL1', 'ALAS1', 'CYP2C8', 'NMNAT1', 'GALM', 'TPH2', 'DCK', 'PTGES', 'DCTPP1', 'MTM1', 'NANP', 'QARS', 'CES1', 'PIGM', 'AZIN2', 'GBGT1', 'PIGB', 'ALG2', 'PAPSS2', 'IMPDH2', 'G6PC2', 'MAN1C1', 'NDUFB7', 'UQCRC2', 'GLUD2', 'PON1', 'CSAD', 'APIP', 'ND4L', 'B3GALT5', 'BCKDHA', 'AOC1', 'NDUFS5', 'PDHB', 'ALPL', 'AASS', 'GUSB', 'BCO1', 'GGPS1', 'ACSS2', 'ATP6V0A1', 'CERS4', 'DBH', 'ITPKA', 'KDSR', 'ND6', 'ATP6AP1', 'ATP5F1', 'CSGALNACT1', 'ATP6V1H', 'GLDC', 'PTGES2', 'ALG11', 'ALG9', 'SUCLG1', 'IDNK', 'ST3GAL6', 'ALPI', 'B4GALT6', 'PRODH2', 'TSTA3', 'HAL', 'GGT5', 'PGM1', 'POLA1', 'ATP6V0E2', 'IDH3A', 'MTMR2', 'PIGC', 'POLE2', 'LALBA', 'CNDP1', 'LPCAT2', 'CYP3A7-CYP3AP1', 'PRIM1', 'TK1', 'COX7B2', 'PGAM1', 'ALG5', 'ATP6V1G1', 'NAGK', 'FAXDC2', 'ETNK1', 'PIGH', 'PIK3C2A', 'FTCD', 'AK2', 'CSGALNACT2', 'CHKB', 'ASMT', 'PLCD3', 'ALG10B', 'ACOX3', 'HPRT1', 'HADHA', 'UGT2A2', 'FDFT1', 'DHRS3', 'MTHFD2', 'MRI1', 'ACAT1', 'ATP6V1A', 'HSD17B4', 'GAA', 'DAD1', 'ACSM2B', 'HEXA', 'POLR3A', 'FAHD1', 'ALDH5A1', 'LIAS', 'MAN2A1', 'GAD2', 'POLD4', 'HYI', 'PGAM4', 'ABO', 'HMBS', 'AGPAT1', 'PAPSS1', 'AGPAT3', 'QPRT', 'ACY1', 'TPH1', 'DGKH', 'HSD17B2', 'IDH3B', 'GPT2', 'RIMKLA', 'ATP5C1', 'PNPLA3', 'ENOPH1', 'CYCS', 'ACAA2', 'UXS1', 'CKMT2', 'CYP2C19', 'ADA', 'CMBL', 'MCAT', 'AKR1B1', 'DCXR', 'UGT1A3', 'NAMPT', 'ARG1', 'PLCB3', 'NME4', 'ACADM', 'SGPL1', 'AMD1', 'PPOX', 'SUCLA2', 'PLD1', 'CYP26C1', 'AK6', 'B4GALT2', 'CHPT1', 'MMAB', 'NDUFA2', 'PGLS', 'COQ6', 'SYNJ1', 'POLR2G', 'TPK1', 'MTMR7', 'ALDH4A1', 'RPEL1', 'CYP4F8', 'HYAL3', 'B3GAT3', 'CRLS1', 'TYMP', 'EXT2', 'RGN', 'CERS6', 'CYP2R1', 'DNMT3A', 'NDUFB5', 'DPM1', 'INPP4A', 'ACSL1', 'UGT1A1', 'RRM2', 'TYMS', 'ALDH1B1', 'GAL3ST1', 'ITPKB', 'COX3', 'GALE', 'NME5', 'PTGES3', 'NT5C1B-RDH14', 'GALNT3', 'ACSS3', 'CHKA', 'PLA2G2A', 'PLA2G12A', 'NAGLU', 'ATP6V0A2', 'BPNT1', 'MCCC2', 'COQ3', 'KYNU', 'AMY1A', 'NDST3', 'GLYCTK', 'PSPH', 'TKTL2', 'RIMKLB', 'G6PC', 'COQ5', 'B3GNT5', 'TDO2', 'ACOT2', 'THTPA', 'GSS', 'CYP2U1', 'ALDH18A1', 'GSTZ1', 'FASN', 'DMGDH', 'SCP2', 'PLCZ1', 'PFKL', 'ACSM2A', 'DNMT3B', 'PRIM2', 'HSD11B1', 'ADSSL1', 'GPT', 'BPGM', 'NDUFA9', 'COX7B', 'GDA', 'ND3', 'IVD', 'B3GNT1', 'CBR1', 'POLR2F', 'ADO', 'PGM2', 'PFKM', 'TALDO1', 'LOC102724788', 'PYCR1', 'ADH1B', 'CHSY3', 'SDSL', 'UGT2B10', 'NDUFB9', 'GCLC', 'MPST', 'NDUFA7', 'ND5', 'ST8SIA1', 'UGT2B11', 'ME3', 'P4HA3', 'FLAD1', 'PPCS', 'PLA2G12B', 'MVK', 'PMM1', 'AGL', 'PLA2G5', 'GCSH', 'DGKI', 'PPAP2A', 'CYP4A11', 'ATP5J2', 'IDH3G', 'CDS2', 'ASL', 'ASS1', 'GLS', 'PLA2G2E', 'PIK3C2G', 'AKR1C3', 'UQCRB', 'PLCB1', 'TWISTNB', 'NDST2', 'LDHA', 'G6PD', 'SDHD', 'AK7', 'PANK1', 'OGDH', 'COX7C', 'DNMT1', 'MTHFR', 'REV3L', 'RPIA', 'CS', 'EXTL1', 'POLR3C', 'ALOX15B', 'ATP5H', 'TH', 'NDUFA10', 'ATP5G3', 'CERS2', 'CHPF', 'GLUL', 'BCKDHB', 'NDUFS6', 'UPRT', 'ATP6V0B', 'FH', 'MCCC1', 'ST3GAL4', 'MSMO1', 'NDUFS1', 'NT5C3A', 'ALDH9A1', 'DGKB', 'LAP3', 'POLR1E', 'PLCD4', 'CYP11A1', 'DGKD', 'CDA', 'GALNT11', 'KL', 'ST6GAL2', 'PIGL', 'ADSL', 'POLE4', 'MGLL', 'ATP5L', 'AGPAT4', 'RDH8', 'ADK', 'HSD3B7', 'NT5C2', 'NDUFB10', 'PTDSS1', 'UGT2B28', 'ATP6V1F', 'HSD17B8', 'MGAT5B', 'GBA3', 'PIGQ', 'HKDC1', 'B4GALT4', 'LTA4H', 'LDHAL6A', 'HSD17B6', 'ASAH1', 'CYP51A1', 'ENO3', 'ATP6V0C', 'GATC', 'KMO', 'ST6GALNAC1', 'RPN1', 'CYP26B1', 'DEGS1', 'DLAT', 'PCCB', 'PTGS1', 'PLA2G4C', 'PIGF', 'POLR3B', 'POLE', 'SC5D', 'ND4', 'AGXT2', 'ATP6V0E1', 'TKT', 'UGT1A8', 'POLR2H', 'GGT1', 'NDUFS7', 'NME6', 'UGT1A9', 'B4GALT3', 'P4HA1', 'MAN1A2', 'FAH', 'STT3B', 'CTPS2', 'KHK', 'GART', 'NDUFS3', 'PLA2G10', 'MLYCD', 'HAAO', 'NDUFB6', 'CYP17A1', 'PC', 'COQ2', 'ACOX2', 'CYP1A2', 'SPHK1', 'PI4K2B', 'LIPT1', 'MTMR14', 'MAN1B1', 'INPP5J', 'PYCRL', 'IMPAD1', 'LDHB', 'XYLB', 'SMPD1', 'CYP2S1', 'PIGO', 'SLC33A1', 'NDUFV2', 'MTHFD2L', 'SPAM1', 'PYGB', 'DGKA', 'GALNT15', 'JMJD7-PLA2G4B', 'OCRL', 'PRODH', 'PTGDS', 'GLB1', 'GALT', 'ND1', 'MGAT4D', 'C1GALT1C1', 'ACOX1', 'PNLIPRP2', 'PCCA', 'PIGV', 'ALDH3A1', 'PIP5K1B', 'PNLIPRP1', 'EPHX2', 'ACSM6', 'CYP2E1', 'DGUOK', 'PMM2', 'NDUFC1', 'GALNT2', 'HAO1', 'ALDH3B2', 'NME1-NME2', 'ACMSD', 'DAO', 'SAT1', 'COX6A2', 'LAMA5', 'ALDOB', 'TKTL1', 'COX5A', 'NDUFB3', 'BDH1', 'ACSL6', 'TYRP1', 'UROS', 'GALNT13', 'FAM213B', 'NUDT12', 'PLA2G6', 'COX5B', 'FBP1', 'INPP5K', 'HGD', 'POLR3G', 'ACAT2', 'TGDS', 'PLA2G4D', 'CYP2C18', 'ATP8', 'CEPT1', 'UPP2', 'POC1B-GALNT4', 'POLR2A', 'PIGY', 'COX6C', 'SEPHS2', 'HLCS', 'PLD4', 'HMGCL', 'ADAM29', 'PI4KB', 'ACSL4', 'NDUFC2-KCTD14', 'MTMR3', 'ALDH2', 'POLR2E', 'CYP2C9', 'AMT', 'PAICS', 'ACOT1', 'ACADVL', 'GALK1', 'POLG', 'PLCG1', 'AMY2B', 'FUT6', 'ADH7', 'HDC', 'MVD', 'B4GALNT1', 'AANAT', 'GALNS', 'HIBCH', 'RDH16', 'PISD', 'RDH11', 'DHODH', 'SPTLC1', 'GAPDH', 'HGSNAT', 'AGMAT', 'NADK', 'ACSS1', 'ATP5G2', 'ALDH3A2', 'ACER1', 'OLAH', 'IDUA', 'SDS', 'HYKK', 'IDS', 'AK4', 'PPT2', 'NAT2', 'DHRS4L2', 'NOS3', 'MAT2A', 'GCNT2', 'MCEE', 'ATP5A1', 'TPI1', 'B3GALT2', 'ST6GALNAC3', 'ATP5D', 'NAGS', 'PLCB2', 'ACOT8', 'GAMT', 'DEGS2', 'PLCE1', 'CYP4F2', 'LCLAT1', 'GALNT1', 'PTGS2', 'CDS1', 'TYR', 'ST6GAL1', 'PGK2', 'PNMT', 'IDO2', 'PLA2G2C', 'ATP6V1D', 'NME7', 'NME2', 'SORD', 'ALDH6A1', 'UPB1', 'HADHB', 'PI4KA', 'MGAM', 'AHCYL2', 'UGT1A6', 'PHOSPHO2', 'POLD1', 'SI', 'ATP6V0D1', 'SDHA', 'FBP2', 'ACSM3', 'UGT2A3', 'CCBL2', 'UQCRC1', 'UQCRH', 'MBOAT2', 'AK8', 'POLG2', 'ADH1C', 'NMNAT3', 'DHCR24', 'CYP24A1', 'COX15', 'ATP6V1B2', 'LOC390877', 'IPPK', 'GGT7', 'PIGN', 'NDST4', 'XYLT1', 'TAT', 'FUT8', 'GMPS', 'CYP3A5', 'POLR2K', 'GALNTL6', 'NDUFA1', 'POLR1D', 'POLR1C', 'CECR1', 'IL4I1', 'LIPC', 'NMRK2', 'ALOX15', 'POLD3', 'AKR1B10', 'RDH10', 'BHMT2', 'MGAT4C', 'ADH6', 'B3GNT2', 'ST3GAL1', 'NFS1', 'PGK1', 'TM7SF2', 'NDUFB2', 'NDUFA4', 'CHIA', 'AGPAT5', 'ATP5I', 'ALOX12', 'PLD3', 'CKB', 'POLR3D', 'TBXAS1', 'INPP5E', 'FOLH1', 'POLR3F', 'CDIPT', 'PGS1', 'HMGCLL1', 'UAP1L1', 'BAAT', 'NME1', 'CTH', 'SPR', 'HPGDS', 'MGAT3', 'DGAT1', 'NDUFB4', 'POLR2B', 'GALC', 'LSS', 'GAPDHS', 'CPOX', 'EHHADH', 'PIGT', 'UGT1A10', 'UGT8', 'ATP6V1G3', 'PLA2G2D', 'AK9', 'MGAT1', 'SPTLC2', 'DOLK', 'PSAT1', 'ODC1', 'GMPPB', 'GALNT14', 'CYP11B2', 'HK2', 'MINPP1', 'PPCDC', 'PCYT1B', 'PDXP', 'DPAGT1', 'ENO1', 'CMPK2', 'ATP6V1E2', 'ALOX12B', 'ST6GALNAC5', 'MDH1', 'UQCR10', 'POLR2I', 'G6PC3', 'GNPDA2', 'ADH5', 'HSD17B7', 'NAT8L', 'ALG10', 'TRAK2', 'CYP19A1', 'ANPEP', 'PIGK', 'RBKS', 'NOS2', 'PAFAH1B2', 'PPT1', 'ATP6V0A4', 'GALNTL5', 'AGPAT6', 'ACO2', 'DGKQ', 'CHDH', 'PKM', 'SDHC', 'B3GALNT1', 'HOGA1', 'UGT2B15', 'PANK3', 'ETNPPL', 'B4GALT1', 'CYP26A1', 'GLS2', 'MGAT4B', 'SGMS1', 'MDH2', 'MTMR6', 'CERS5', 'COX11', 'NNT', 'PMVK', 'PDHX', 'FUT4', 'NDUFS4', 'MOCS1', 'TREH', 'DGKK', 'MTMR1', 'DHCR7', 'COX1', 'POLE3', 'PLA2G16', 'RPE', 'NME3', 'SDHB', 'SAT2', 'UAP1', 'CYP2B6', 'AGK', 'LDHAL6B', 'ATP5B', 'POLR2D', 'MAT1A', 'ACADL', 'ENPP3', 'MOCS2', 'PIGS', 'AK5', 'GATB', 'A4GALT', 'GLUD1', 'PKLR', 'UCKL1', 'PTS', 'PRPS2', 'ACER2', 'CYP27B1', 'LPIN1', 'DDC', 'EARS2', 'PYGL', 'ACSBG2', 'CYP3A4', 'COMT', 'MTAP', 'ST8SIA5', 'CPS1', 'ATIC', 'MTHFS', 'TPO', 'ACSM1', 'HPD', 'HEXB', 'GALNT12', 'PLA2G2F', 'CRYL1', 'PGM3', 'CERS3', 'AOX1', 'CBR3', 'IDH1', 'LPCAT4', 'HSD17B1', 'UGT2B7', 'CYP11B1', 'HYAL1', 'NDUFA4L2', 'DHRS9', 'DUT', 'SCLY', 'AMY1C', 'AADAT', 'PON2', 'PLA2G4B', 'DHRS4', 'NDUFA3', 'NAPRT', 'ND2', 'NNMT', 'AMPD2', 'OTC', 'NDST1', 'SYNJ2', 'UGT1A5', 'ATP5O', 'UQCR11', 'DPYS', 'FUK', 'PIPOX', 'PGAP1', 'ALOX5', 'ATP5J', 'NDUFB8', 'POLR3H', 'COX4I2', 'ETNK2', 'CYTB', 'GNS', 'SGSH', 'ACAA1', 'NDUFA5', 'NANS', 'MGAT2', 'ALPPL2', 'UQCRQ', 'PIGP', 'MBOAT1', 'COX6B2', 'MGAT4A', 'PIP5K1C', 'CBS', 'ABAT', 'ENO2', 'DGKZ', 'NTPCR', 'GALNT8', 'PIGU', 'GLCE', 'MTMR8', 'GALNT18', 'NDUFS8', 'DCTD', 'PANK2', 'ATP6V1E1', 'SQLE', 'GK2', 'GCK', 'TRIT1', 'NDUFA8', 'UCK1', 'SMPD3', 'TST', 'GALNT10', 'CYP4F3', 'AMY1B', 'POLR2J3', 'DHFR', 'BTD', 'HPSE2', 'ASAH2', 'OGDHL', 'POLR2J2', 'NDUFA13', 'PRPS1', 'PPAT', 'SUCLG2', 'AKR1D1', 'P4HA2', 'SRM', 'PYCR2', 'RFK', 'LOC102724560', 'ALAS2', 'COX6B1', 'PGD', 'GGT6', 'IDI2', 'NT5C1B', 'ST3GAL3', 'NT5C3B', 'ENPP1', 'COX4I1', 'PNPO', 'ACLY', 'PEMT', 'MGAT5', 'PLD2', 'ATP6V1G2', 'PCK1', 'GPAM', 'ALG6', 'ME1', 'UPP1', 'HK1', 'XDH', 'INPP4B', 'NSDHL', 'LAMA3', 'COQ7', 'DDOST', 'SMPD2', 'MPI', 'CMPK1', 'PLA2G4A', 'AMPD1', 'HIBADH', 'ALDH3B1', 'PPAP2C', 'ECHS1', 'PLCB4', 'PLCH2', 'CDO1', 'AFMID', 'TUSC3', 'PIK3C3', 'AGPS', 'ALG12', 'QRSL1', 'ACSM4', 'CHSY1', 'PLCH1', 'PGP', 'BHMT', 'PAH', 'CAD', 'PDXK', 'GCNT1', 'HYAL4', 'NAT1', 'NDUFA11', 'DPM3', 'DBT', 'POLR1B', 'ALAD', 'HAO2', 'ACACA', 'ACO1', 'GANC', 'PAFAH1B1', 'HSD3B1', 'PIP5KL1', 'HSD17B3', 'GPAA1', 'GBE1', 'GOT2', 'PRPS1L1', 'SMPD4', 'ADSS', 'EPRS', 'CYP7A1', 'AMDHD1', 'NADK2', 'COX8A', 'RRM1', 'C1GALT1', 'GFPT2', 'GOT1', 'AKR1A1', 'AGPAT9', 'CNDP2', 'NDUFV3', 'CCBL1', 'NDUFS2', 'CERS1', 'IMPA1', 'DHRS4L1', 'ATP6V1C2', 'POLA2', 'UGT2B17', 'DPYD', 'POLR2C', 'ACACB', 'AGXT', 'PIP5K1A', 'PIGX', 'DPM2', 'AMPD3', 'ALG14', 'ADI1', 'B3GNT3', 'POLR2J', 'GALNT4', 'OAT', 'BCAT2', 'NDUFAB1', 'ACADSB', 'NT5C1A', 'ALDH1A1', 'PI4K2A', 'EXTL3', 'RRM2B', 'HK3', 'ALDH1A2', 'IPMK', 'LDHC', 'AHCY', 'TK2', 'FUT7', 'B3GALT1', 'DSE', 'FUT5', 'ADH4', 'PFAS', 'PIGA', 'PDHA1', 'CYP27A1', 'UGT2B4', 'FUT2', 'B3GNT4', 'DCT', 'DGAT2', 'ADPGK', 'GPAT2', 'GNPDA1', 'MECR', 'HSD17B10', 'HSD3B2', 'LPCAT1', 'PAFAH2', 'PTDSS2', 'FUT3', 'GK', 'DLST', 'HYAL2', 'PNPLA2', 'ATP5E', 'ST6GALNAC6', 'NDUFA6', 'DHFRL1', 'GBA', 'H6PD', 'GCNT3', 'SPTLC3', 'PPAP2B', 'GMDS', 'NDUFV1', 'LIPF', 'MTMR4', 'PNLIP', 'BST1', 'ATP6', 'PLCD1', 'GPI', 'ITPA', 'SLC27A5', 'HMGCS2', 'PHOSPHO1', 'MAN1A1', 'GCLM', 'SPHK2', 'ST3GAL5', 'ASNS', 'GCDH', 'PHYKPL', 'CD38', 'ISYNA1', 'CHIT1', 'PCYT2', 'ARG2', 'DGKE', 'GATM', 'ALDH7A1', 'POLR3K', 'CYP3A7', 'ATP5G1', 'GCNT4', 'CYP1A1', 'MTHFD1', 'INPP1', 'PDHA2', 'GFPT1', 'ACSL3', 'PRDX6', 'POLR1A', 'PON3', 'PCK2', 'NMRK1', 'GALNT7', 'GAD1', 'GNE', 'CYC1', 'LIPG', 'PGAM2', 'NMNAT2', 'RDH12', 'AMY2A', 'CYP2A6', 'PIGW', 'AUH', 'MOGS', 'SARDH', 'PNP', 'PTGIS', 'MAOA', 'ALG3', 'SEPHS1', 'CMAS', 'IDO1', 'COX2', 'COX17', 'ADH1A', 'PLA2G3', 'CYP21A2', 'SGMS2', 'GALNT16', 'IMPDH1', 'ITPKC', 'B4GALT7', 'NDUFB11', 'SMS', 'COASY', 'AK1', 'MUT', 'UROC1', 'GRHPR', 'PLCG2', 'ASPA', 'LIPT2', 'CHPF2', 'NADSYN1', 'RPN2', 'PAFAH1B3', 'POLR2L', 'APRT', 'NDUFA12', 'GALNT6', 'ST3GAL2', 'NDUFB1', 'UQCRHL', 'NDUFC2', 'HMGCR', 'GANAB', 'COX8C', 'BDH2', 'IMPA2', 'ALDOA', 'PHGDH', 'FUT1', 'PLA2G7', 'ACSM5', 'FUT9', 'GBA2', 'FPGS', 'POLD2', 'EXTL2', 'DAK', 'PLA2G1B', 'NT5C', 'UQCRFS1', 'COX10', 'UROD', 'QDPR', 'CKM', 'ST20-MTHFS', 'ARSB', 'ST6GALNAC4', 'WBSCR17', 'AOC3', 'CEL', 'PLA2G4F', 'ACSBG1', 'UCK2', 'FECH', 'CTPS1', 'EPT1', 'ALLC', 'AGPAT2', 'ALDH1A3', 'BCAT1', 'B3GALT4', 'UGP2', 'PCYT1A'}, 'Amyotrophic lateral sclerosis (ALS) Homo sapiens hsa05014': {'MAP3K5', 'RAB5A', 'SOD1', 'TOMM40', 'TNFRSF1B', 'BAD', 'GRIA2', 'CCS', 'GPX1', 'SLC1A2', 'GRIN2B', 'NEFH', 'BID', 'MAPK13', 'BCL2', 'BAX', 'PPP3CB', 'CASP1', 'PPP3CC', 'RAC1', 'CAT', 'CASP12', 'MAPK14', 'MAP2K3', 'CYCS', 'TOMM40L', 'NOS1', 'CASP3', 'MAPK12', 'PPP3R2', 'ALS2', 'GRIN1', 'MAPK11', 'GRIA1', 'GRIN2A', 'DERL1', 'CASP9', 'TNF', 'NEFM', 'NEFL', 'APAF1', 'PRPH', 'PPP3R1', 'DAXX', 'GRIN2D', 'GRIN2C', 'TP53', 'PPP3CA', 'MAP2K6', 'TNFRSF1A', 'BCL2L1'}, 'Nicotine addiction Homo sapiens hsa05033': {'GABRE', 'CACNA1A', 'GABRP', 'SLC17A7', 'GABRA4', 'GRIA2', 'GRIA3', 'CACNA1B', 'GABRR2', 'GABRR1', 'CHRNB2', 'CHRNA4', 'GRIN2B', 'SLC32A1', 'GABRB3', 'GABRQ', 'GABRG2', 'GABRG3', 'GABRB2', 'GRIN3A', 'GRIN1', 'GRIA1', 'GRIN2A', 'CHRNA7', 'GABRA6', 'GABRA3', 'GABRA2', 'GABRD', 'SLC17A6', 'GABRB1', 'GRIN3B', 'GABRA1', 'GABRR3', 'GABRA5', 'GRIN2D', 'GRIN2C', 'SLC17A8', 'GABRG1', 'CHRNA6', 'GRIA4'}, 'Neuroactive ligand-receptor interaction Homo sapiens hsa04080': {'GABRE', 'BRS3', 'CHRM1', 'SSTR4', 'OPRD1', 'MLNR', 'GABRP', 'THRB', 'GABRA4', 'GABRR2', 'GRIK2', 'GABRR1', 'GRIN2B', 'OXTR', 'CHRNA9', 'GRIK4', 'S1PR5', 'GABRB3', 'HTR1D', 'HTR1B', 'FSHB', 'SSTR5', 'GRM4', 'LEPR', 'P2RY10', 'PTGER1', 'FSHR', 'P2RY14', 'TBXA2R', 'P2RY8', 'GABRB2', 'S1PR2', 'LPAR6', 'TACR3', 'GRM5', 'GLRA1', 'GZMA', 'CHRNB3', 'MCHR2', 'CCKBR', 'GRID1', 'HTR2B', 'LTB4R2', 'LPAR1', 'PTH1R', 'GRIN1', 'AVPR1B', 'ADORA2A', 'PTGIR', 'HCRTR1', 'GRIK1', 'CHRNA3', 'TSHR', 'NPFFR2', 'GABRA1', 'HTR1A', 'GRM3', 'CHRNA10', 'NPBWR1', 'MCHR1', 'BDKRB2', 'AVPR1A', 'RXFP1', 'TSHB', 'F2', 'NPFFR1', 'LTB4R', 'LEP', 'CRHR2', 'P2RY13', 'PTGFR', 'TAAR5', 'GHR', 'F2RL2', 'CNR2', 'TACR1', 'TAAR6', 'GRIA3', 'CRHR1', 'GCGR', 'DRD1', 'NMUR2', 'CHRNA4', 'LPAR3', 'CCKAR', 'GPR156', 'PTAFR', 'NPY1R', 'ADRA2A', 'HTR7', 'GABRG2', 'GH1', 'SCTR', 'HRH4', 'GRPR', 'TAAR8', 'MTNR1A', 'HRH1', 'MC5R', 'NPBWR2', 'VIPR2', 'HTR1F', 'F2RL1', 'KISS1R', 'C3AR1', 'P2RX2', 'GABBR1', 'LOC100996758', 'CHRND', 'P2RY4', 'GRM7', 'GRIN2A', 'PLG', 'NTSR2', 'MC4R', 'CHRNG', 'AGTR1', 'CHRNA5', 'MC2R', 'CALCRL', 'CHRM5', 'P2RY1', 'P2RX6', 'CHRNE', 'GABRB1', 'GRIN3B', 'SSTR2', 'TRHR', 'MC1R', 'GABRA5', 'CALCR', 'FPR1', 'OPRL1', 'CSH2', 'PARD3', 'HCRTR2', 'CHRNA6', 'GRIA4', 'P2RX5', 'GRIK5', 'C5AR1', 'EDNRB', 'ADRA2B', 'GHSR', 'MAS1', 'GLRA3', 'PRSS1', 'ADRA1D', 'NMUR1', 'AGTR2', 'NR3C1', 'ADORA2B', 'CHRM4', 'CYSLTR2', 'NPY4R', 'HTR2A', 'CHRNB2', 'THRA', 'GPR35', 'GABBR2', 'PRSS3', 'GHRHR', 'GRID2', 'ADRB2', 'CNR1', 'PRL', 'CHRNB4', 'HRH3', 'GH2', 'GABRG3', 'ADORA3', 'TAAR9', 'TAAR1', 'S1PR3', 'P2RX1', 'TSPO', 'CHRNB1', 'CHRNA2', 'GRIN3A', 'TACR2', 'GALR3', 'P2RX4', 'HRH2', 'GNRHR', 'LPAR2', 'GRM1', 'RXFP4', 'BDKRB1', 'HTR4', 'P2RX3', 'CHRNA7', 'CTSG', 'CHRM3', 'NMBR', 'HTR6', 'GABRA2', 'P2RY11', 'MC3R', 'PTGER2', 'GABRD', 'VIPR1', 'ADORA1', 'GABRR3', 'RXFP2', 'NTSR1', 'PTGDR', 'AVPR2', 'NPY2R', 'OPRM1', 'GRIN2D', 'ADRA1A', 'GABRG1', 'PRSS2', 'SSTR3', 'DRD5', 'CYSLTR1', 'NPY5R', 'P2RY2', 'EDNRA', 'OPRK1', 'LHB', 'LPAR4', 'GRIA2', 'HTR2C', 'GLP2R', 'APLNR', 'GABRQ', 'CHRNA1', 'CGA', 'MTNR1B', 'CSH1', 'DRD3', 'GRIK3', 'UTS2R', 'P2RY6', 'GRM6', 'PTGER3', 'ADRB1', 'S1PR1', 'GLP1R', 'TRPV1', 'GRM8', 'RXFP3', 'F2RL3', 'TAAR2', 'ADCYAP1R1', 'DRD2', 'GALR2', 'ADRB3', 'GRIA1', 'GLRB', 'HTR1E', 'GABRA6', 'F2R', 'PRLHR', 'GIPR', 'GALR1', 'GABRA3', 'GPR50', 'PRLR', 'LHCGR', 'GLRA2', 'GPR83', 'FPR3', 'HTR5A', 'SSTR1', 'DRD4', 'ADRA1B', 'CHRM2', 'ADRA2C', 'GRM2', 'GRIN2C', 'P2RX7', 'PTH2R', 'PTGER4', 'S1PR4', 'FPR2'}, 'Taste transduction Homo sapiens hsa04742': {'TAS2R45', 'ADCY6', 'TAS2R39', 'GABRA4', 'GNB3', 'HTR1D', 'GRM4', 'HTR1B', 'TAS2R19', 'CALHM1', 'TAS2R30', 'TAS2R13', 'ITPR3', 'KCNK5', 'GABRA1', 'HTR1A', 'TAS2R38', 'TRPM5', 'CACNA1A', 'HTR3D', 'SCNN1G', 'TAS2R7', 'HTR3A', 'HTR1F', 'TAS2R8', 'P2RX2', 'GABBR1', 'TAS2R20', 'P2RY4', 'SCN2A', 'TAS2R31', 'P2RY1', 'ADCY4', 'HTR3C', 'PDE1B', 'GABRA5', 'ENTPD2', 'TAS2R14', 'TAS2R5', 'HTR3E', 'GNAT3', 'ASIC2', 'CACNA1C', 'GABBR2', 'TAS2R41', 'PLCB2', 'TAS2R43', 'ADCY8', 'TAS2R1', 'TAS2R4', 'SCNN1A', 'PDE1A', 'HCN4', 'SCNN1B', 'TAS2R50', 'GRM1', 'PDE1C', 'P2RX3', 'PKD1L3', 'CHRM3', 'GABRA2', 'SCN9A', 'TAS1R2', 'TAS2R10', 'TAS2R3', 'GNG13', 'SCN3A', 'TAS2R42', 'TAS2R40', 'PRKACA', 'PKD2L1', 'TAS2R46', 'TAS2R9', 'PRKACG', 'TAS2R16', 'HTR1E', 'GABRA6', 'TAS2R60', 'GABRA3', 'TAS1R3', 'HTR3B', 'TAS1R1', 'PRKACB'}, 'Olfactory transduction Homo sapiens hsa04740': {'OR2M2', 'OR8G2', 'OR51E1', 'OR10A4', 'CAMK2G', 'OR51D1', 'OR4C12', 'OR5B17', 'OR2M3', 'OR2D2', 'OR56A1', 'OR2T27', 'OR2J2', 'OR4E2', 'OR5B3', 'OR6P1', 'OR4D9', 'OR7G3', 'OR10Z1', 'OR5M1', 'OR4C13', 'OR5R1', 'OR7A5', 'OR2AP1', 'OR5V1', 'OR10G8', 'OR8D4', 'OR4D10', 'OR10AD1', 'OR10A6', 'OR2A12', 'OR10H1', 'OR5M9', 'OR5AK2', 'OR6C74', 'GUCY2D', 'OR52B4', 'OR5L2', 'OR5T1', 'OR4X1', 'OR8H1', 'CALM2', 'OR6T1', 'OR1G1', 'OR10G2', 'OR6X1', 'OR2B11', 'OR10S1', 'OR9A4', 'OR4F16', 'OR4D2', 'PDE1A', 'OR2T34', 'OR6F1', 'OR4K13', 'OR52I2', 'PDE1C', 'OR11G2', 'OR56B4', 'OR4S1', 'CALM3', 'OR52N2', 'ARRB2', 'OR4K2', 'OR5W2', 'OR5T2', 'OR13C9', 'OR9K2', 'OR2G2', 'OR2T5', 'OR5H14', 'OR4A47', 'GNG13', 'OR52E4', 'OR1E1', 'OR4K15', 'OR52H1', 'OR8D2', 'OR52R1', 'OR1K1', 'OR9G9', 'PDE2A', 'OR6N2', 'OR3A2', 'OR5K2', 'PRKACA', 'OR4A15', 'OR10G9', 'OR6C76', 'OR8B4', 'OR2A42', 'OR13C8', 'OR2L13', 'OR51G1', 'OR5M3', 'OR2AG2', 'OR8H3', 'OR5D16', 'OR2C3', 'OR5J2', 'OR6K6', 'OR5AS1', 'OR13C5', 'OR8U8', 'OR51V1', 'CAMK2D', 'OR1C1', 'OR51I1', 'OR5AU1', 'OR8B8', 'OR10A2', 'OR10X1', 'OR9G1', 'OR10H4', 'OR6C4', 'OR1E2', 'OR5K1', 'OR8G1', 'OR1S2', 'OR13G1', 'OR2AG1', 'OR2H1', 'PRKG2', 'OR8J1', 'OR2L3', 'OR7C2', 'OR5B2', 'OR1A2', 'OR4K1', 'OR52A5', 'OR10H2', 'OR52K1', 'OR13J1', 'OR2W3', 'OR2L2', 'OR4C45', 'OR1L6', 'OR5B21', 'OR8D1', 'OR6B2', 'OR56A3', 'OR2A1', 'OR10K1', 'CAMK2B', 'OR2C1', 'OR6C6', 'OR4S2', 'OR3A3', 'OR9Q2', 'SLC8A1', 'OR2F2', 'OR5H2', 'OR2M7', 'OR8U1', 'OR4L1', 'OR51F1', 'SLC24A4', 'OR51E2', 'OR52N5', 'OR2T11', 'OR8K3', 'OR4K17', 'OR8U9', 'OR1M1', 'OR2F1', 'SLC8A2', 'OR10J1', 'OR4A16', 'OR52E8', 'OR2G6', 'OR5C1', 'OR4X2', 'OR14C36', 'OR51B2', 'CNGA4', 'CNGB1', 'OR11H6', 'OR14I1', 'OR4C46', 'OR2L5', 'CNGA2', 'OR2D3', 'OR2T10', 'OR4F5', 'OR10A3', 'OR13D1', 'OR2T3', 'OR4N5', 'OR5H1', 'OR4P4', 'OR2A25', 'OR2A4', 'OR51I2', 'OR6A2', 'OR8A1', 'GNAL', 'OR51F2', 'OR13F1', 'OR2T4', 'OR4C6', 'OR52E2', 'ADRBK2', 'OR51B6', 'OR6S1', 'OR4C16', 'ADCY3', 'OR6K2', 'OR10J5', 'SLC8A3', 'ADRBK1', 'OR51B5', 'OR56B1', 'OR4D5', 'OR10P1', 'OR52N1', 'CALM1', 'OR2T8', 'OR2B2', 'OR52B6', 'CALML6', 'OR5AN1', 'OR7G1', 'OR52A1', 'OR2Z1', 'NCALD', 'OR10A7', 'OR52K2', 'OR5D14', 'OR8S1', 'OR52L1', 'OR13C3', 'OR10T2', 'OR51B4', 'LOC102723532', 'OR6B1', 'OR1F1', 'OR51L1', 'OR13C2', 'OR4K14', 'OR7A10', 'PDE1B', 'OR5T3', 'OR51G2', 'OR52J3', 'OR4D1', 'OR8I2', 'OR1S1', 'OR4M1', 'OR10J3', 'OR51A4', 'OR9G4', 'OR4B1', 'OR6B3', 'OR7A17', 'OR6C2', 'OR1I1', 'OR52I1', 'OR1L1', 'OR10W1', 'OR8H2', 'OR2S2', 'OR51A2', 'OR5B12', 'OR9A2', 'OR2T33', 'OR1A1', 'OR11A1', 'OR2T1', 'OR5F1', 'OR2G3', 'OR5I1', 'OR1B1', 'OR10R2', 'OR8B2', 'OR2K2', 'OR6C75', 'OR4D11', 'OR7E24', 'OR2Y1', 'OR6C68', 'OR5AC2', 'OR7D2', 'OR6M1', 'OR12D2', 'OR2M5', 'OR51A7', 'OR4C3', 'OR51T1', 'OR11H4', 'OR51M1', 'OR12D3', 'OR10H3', 'PRKACG', 'OR1D2', 'OR2L8', 'OR5AR1', 'OR4F29', 'OR2T29', 'OR51S1', 'OR5K3', 'OR1L4', 'OR6Q1', 'OR1N1', 'OR7C1', 'OR4A5', 'OR5D13', 'OR2AK2', 'OR10G7', 'OR2V1', 'OR10G4', 'OR5M10', 'OR56A4', 'OR8G5', 'OR5A1', 'OR51Q1', 'OR5K4', 'OR6K3', 'OR5M11', 'OR6C3', 'OR5L1', 'OR10A5', 'OR10AG1', 'OR52B2', 'OR2W1', 'OR4Q3', 'OR6N1', 'OR2T2', 'OR8B12', 'OR1J1', 'OR2B3', 'OR10V1', 'OR52E6', 'OR2A5', 'OR2V2', 'OR56A5', 'OR4F15', 'OR2A14', 'OR9I1', 'OR52N4', 'OR11H1', 'OR6C65', 'OR8K1', 'OR1D5', 'OR5P2', 'OR6V1', 'OR4C11', 'OR11L1', 'OR2M4', 'OR1N2', 'OR2AT4', 'OR1J4', 'OR52M1', 'CALML3', 'OR10G3', 'OR1L8', 'OR4F4', 'OR13C4', 'OR4M2', 'OR6Y1', 'OR5M8', 'OR6C1', 'OR5A2', 'OR7G2', 'OR5P3', 'OR5H6', 'OR1L3', 'GNG7', 'OR1Q1', 'OR8B3', 'RGS2', 'OR2T6', 'OR2J3', 'OR52W1', 'OR10H5', 'OR4F3', 'OR2A7', 'OR4C15', 'OR14J1', 'OR9Q1', 'OR7D4', 'OR10Q1', 'CAMK2A', 'OR2T12', 'OR4F17', 'OR2AE1', 'OR4F21', 'OR10C1', 'OR2A2', 'OR2B6', 'OR13H1', 'OR5D18', 'OR4N2', 'ANO2', 'OR4F6', 'OR6C70', 'OR14A16', 'OR8J3', 'OR11H12', 'GNB1', 'OR5AP2', 'ARRB1', 'OR1J2', 'OR3A1', 'CNGA3', 'OR10K2', 'OR4K5', 'OR52D1', 'OR2H2', 'OR4D6', 'OR8K5', 'OR4N4', 'PRKG1', 'OR13A1', 'PRKACB', 'CALML5'}, 'Phototransduction Homo sapiens hsa04744': {'GNAT1', 'CNGB1', 'PDE6G', 'CNGA1', 'SLC24A1', 'GNB1', 'GNAT2', 'GUCA1B', 'PDE6A', 'RHO', 'GUCA1A', 'GUCY2F', 'CALM1', 'RGS9', 'GRK1', 'CALML3', 'RCVRN', 'GNGT1', 'CALM3', 'PDE6B', 'GUCY2D', 'CALM2', 'SAG', 'GUCA1C', 'GRK7', 'CALML6', 'CALML5'}, 'Circadian rhythm Homo sapiens hsa04710': {'PER1', 'CLOCK', 'ARNTL', 'SKP1', 'FBXL3', 'PRKAG2', 'RORA', 'BTRC', 'RBX1', 'PRKAG3', 'CSNK1E', 'PER3', 'FBXW11', 'RORB', 'PRKAA2', 'CRY1', 'NPAS2', 'PER2', 'CRY2', 'PRKAB2', 'CUL1', 'PRKAB1', 'CSNK1D', 'BHLHE41', 'RORC', 'BHLHE40', 'PRKAG1', 'NR1D1', 'PRKAA1', 'CREB1'}, 'Glycerolipid metabolism Homo sapiens hsa00561': {'AKR1A1', 'AGPAT9', 'PNLIPRP3', 'ALDH9A1', 'PNLIP', 'PPAP2A', 'DGKI', 'ALDH3A2', 'DGKG', 'DGKB', 'ALDH2', 'DGKH', 'LPL', 'MBOAT1', 'PNLIPRP2', 'GK2', 'DGKD', 'LIPG', 'AGPAT6', 'LPIN3', 'DGKQ', 'PNLIPRP1', 'PNPLA3', 'MOGAT2', 'CEL', 'MBOAT2', 'ALDH1B1', 'AGPAT5', 'LIPF', 'DGKZ', 'LIPC', 'DGKA', 'LCLAT1', 'AKR1B10', 'LPIN1', 'MGLL', 'GLA', 'GK', 'AGPAT2', 'PPAP2C', 'DGKK', 'AGPAT4', 'PPAP2B', 'LPIN2', 'MOGAT3', 'AGK', 'DAK', 'DGKE', 'MOGAT1', 'DGAT1', 'ALDH7A1', 'GPAM', 'GLYCTK', 'DGAT2', 'AGPAT1', 'PNPLA2', 'AKR1B1', 'AGPAT3', 'GPAT2'}, 'Glycerophospholipid metabolism Homo sapiens hsa00564': {'LPCAT2', 'AGPAT9', 'PTDSS1', 'LYPLA1', 'MBOAT7', 'PLA2G16', 'CRLS1', 'CHAT', 'PLA2G2D', 'MBOAT2', 'ETNK1', 'ETNK2', 'DGKA', 'PLA2G12B', 'PEMT', 'JMJD7-PLA2G4B', 'PLD2', 'PLA2G3', 'PPAP2B', 'PISD', 'CHKB', 'GPAM', 'PLA2G15', 'PLA2G5', 'DGKI', 'PPAP2A', 'DGKG', 'PCYT1B', 'CDS2', 'GNPAT', 'CHKA', 'MBOAT1', 'ACHE', 'PLA2G2A', 'PLA2G12A', 'PLA2G2E', 'PHOSPHO1', 'LPCAT3', 'PLA2G4C', 'PLB1', 'DGKZ', 'PLA2G4A', 'LPIN1', 'PCYT2', 'PPAP2C', 'LPIN2', 'DGKE', 'PLA2G4E', 'GPD1L', 'AGPAT1', 'AGPAT3', 'LPGAT1', 'DGKH', 'TAZ', 'PLA2G2F', 'AGPAT6', 'GPD1', 'LPIN3', 'DGKQ', 'AGPAT5', 'PLA2G6', 'ADPRM', 'LCAT', 'LCLAT1', 'PLD3', 'ETNPPL', 'LPCAT4', 'CDS1', 'PLA2G1B', 'GPD2', 'GPAT2', 'DGKB', 'PLA2G10', 'PLA2G4D', 'PLA2G2C', 'CDIPT', 'PGS1', 'DGKD', 'LPCAT1', 'PNPLA7', 'CEPT1', 'PLD1', 'PLA2G4B', 'PLA2G4F', 'PNPLA6', 'CHPT1', 'EPT1', 'PTDSS2', 'GPCPD1', 'AGPAT2', 'DGKK', 'AGPAT4', 'LYPLA2', 'PLD4', 'PCYT1A'}, 'Ether lipid metabolism Homo sapiens hsa00565': {'PLA2G5', 'LPCAT2', 'AGPS', 'PPAP2A', 'PLA2G2F', 'PLA2G10', 'PAFAH1B2', 'PLA2G4D', 'PLA2G2C', 'PLA2G16', 'PLA2G12A', 'PLA2G2A', 'PLA2G2E', 'LPCAT1', 'PLA2G4C', 'CEPT1', 'PLB1', 'UGT8', 'PAFAH1B1', 'PLA2G2D', 'PLD1', 'PLA2G4B', 'PAFAH2', 'PAFAH1B3', 'PLA2G4F', 'PLA2G7', 'TMEM86B', 'PLA2G4A', 'PLA2G6', 'PLA2G12B', 'EPT1', 'CHPT1', 'PPAP2C', 'JMJD7-PLA2G4B', 'PLA2G3', 'PLD2', 'PLD3', 'ENPP6', 'PPAP2B', 'PLA2G4E', 'LPCAT4', 'GAL3ST1', 'PLA2G1B', 'ENPP2', 'PLD4'}, 'alpha-Linolenic acid metabolism Homo sapiens hsa00592': {'PLA2G5', 'ACOX3', 'PLA2G10', 'PLA2G2F', 'ACOX1', 'PLA2G4D', 'PLA2G2C', 'PLA2G16', 'PLA2G12A', 'PLA2G2A', 'PLA2G2E', 'PLA2G4C', 'PLB1', 'PLA2G2D', 'PLA2G4B', 'PLA2G4F', 'PLA2G4A', 'PLA2G6', 'PLA2G12B', 'JMJD7-PLA2G4B', 'PLA2G3', 'PLA2G4E', 'FADS2', 'PLA2G1B', 'ACAA1'}, 'Linoleic acid metabolism Homo sapiens hsa00591': {'PLA2G5', 'CYP2J2', 'PLA2G10', 'PLA2G2F', 'PLA2G4D', 'CYP2C9', 'PLA2G16', 'PLA2G2C', 'PLA2G12A', 'PLA2G2A', 'CYP2C8', 'PLA2G2E', 'PLA2G4C', 'PLB1', 'PLA2G2D', 'PLA2G4B', 'PLA2G4F', 'CYP1A2', 'CYP2E1', 'PLA2G4A', 'ALOX15', 'PLA2G6', 'PLA2G12B', 'CYP2C19', 'JMJD7-PLA2G4B', 'PLA2G3', 'PLA2G4E', 'CYP3A4', 'PLA2G1B'}, 'Arachidonic acid metabolism Homo sapiens hsa00590': {'PLA2G5', 'PTGDS', 'PTGES3', 'CYP4A11', 'PTGIS', 'CYP4F8', 'CYP2J2', 'GGT1', 'ALOX15B', 'PLA2G2F', 'GPX1', 'PLA2G10', 'PLA2G4D', 'CYP2C9', 'PLA2G2C', 'PLA2G16', 'PLA2G2A', 'CYP2C8', 'PLA2G12A', 'PLA2G2E', 'GPX3', 'ALOX5', 'PTGS1', 'ALOX12B', 'AKR1C3', 'PLA2G4C', 'PLB1', 'LTA4H', 'PLA2G2D', 'CYP2U1', 'GGT5', 'PLA2G4B', 'EPHX2', 'PLA2G4F', 'CBR1', 'PTGES', 'CYP2E1', 'PLA2G4A', 'ALOX15', 'FAM213B', 'GPX8', 'ALOX12', 'CYP4F2', 'CYP4F3', 'PLA2G6', 'GPX7', 'GPX6', 'HPGDS', 'PTGES2', 'PLA2G12B', 'CYP2C19', 'PTGS2', 'LTC4S', 'CYP2B6', 'JMJD7-PLA2G4B', 'PLA2G3', 'CBR3', 'PLA2G4E', 'GPX2', 'PLA2G1B', 'TBXAS1', 'GPX5'}, 'Fat digestion and absorption Homo sapiens hsa04975': {'PLA2G5', 'PNLIP', 'ACAT2', 'PPAP2A', 'CLPS', 'ABCG5', 'PLA2G10', 'PLA2G2F', 'APOA1', 'PLA2G2C', 'PNLIPRP2', 'PLA2G12A', 'PLA2G2A', 'FABP2', 'PLA2G2E', 'SCARB1', 'ABCA1', 'PNLIPRP1', 'PLA2G2D', 'ABCG8', 'APOB', 'MOGAT2', 'CEL', 'SLC27A4', 'MTTP', 'GOT2', 'PLA2G12B', 'APOA4', 'PPAP2C', 'AGPAT2', 'PLA2G3', 'FABP1', 'CD36', 'PPAP2B', 'DGAT1', 'MOGAT3', 'PLA2G1B', 'DGAT2', 'AGPAT1', 'NPC1L1', 'LIPF'}, 'Vitamin digestion and absorption Homo sapiens hsa04977': {'SLC19A1', 'PNLIP', 'CUBN', 'APOA1', 'SCARB1', 'SLC5A6', 'GIF', 'PLB1', 'ABCC1', 'SLC46A1', 'APOB', 'TCN2', 'SLC52A3', 'LMBRD1', 'SLC23A1', 'RBP2', 'SLC19A2', 'AWAT2', 'APOA4', 'LRAT', 'BTD', 'SLC19A3', 'FOLH1', 'MMACHC'}, 'Notch signaling pathway Homo sapiens hsa04330': {'RBPJL', 'HES1', 'PSEN1', 'NOTCH3', 'PTCRA', 'RFNG', 'RBPJ', 'APH1B', 'DVL2', 'SNW1', 'ADAM17', 'NUMBL', 'MAML3', 'DTX2', 'DTX4', 'DLL1', 'MFNG', 'HDAC2', 'APH1A', 'DVL1', 'NCSTN', 'DTX1', 'JAG2', 'NUMB', 'CTBP2', 'EP300', 'DLL4', 'DVL3', 'KAT2A', 'CIR1', 'NOTCH4', 'NOTCH2', 'CREBBP', 'MAML2', 'DTX3L', 'NOTCH1', 'DTX3', 'PSEN2', 'NCOR2', 'PSENEN', 'LFNG', 'HES5', 'KAT2B', 'HDAC1', 'MAML1', 'DLL3', 'JAG1', 'CTBP1'}, 'Maturity onset diabetes of the young Homo sapiens hsa04950': {'HES1', 'NEUROG3', 'PDX1', 'NKX2-2', 'FOXA3', 'IAPP', 'PKLR', 'GCK', 'BHLHA15', 'HNF1B', 'HNF4G', 'PAX4', 'ONECUT1', 'HNF1A', 'INS', 'PAX6', 'HNF4A', 'RFX6', 'HHEX', 'MNX1', 'FOXA2', 'NR5A2', 'NEUROD1', 'NKX6-1', 'SLC2A2', 'MAFA'}, 'Basal transcription factors Homo sapiens hsa03022': {'TAF4', 'ERCC2', 'TAF9', 'TAF8', 'GTF2H4', 'TAF7', 'GTF2H5', 'GTF2A2', 'GTF2A1', 'TAF1', 'GTF2H2C', 'CCNH', 'GTF2B', 'TBPL1', 'TBPL2', 'TAF5', 'MNAT1', 'ERCC3', 'GTF2E2', 'TBP', 'TAF12', 'GTF2H2', 'TAF2', 'GTF2H1', 'GTF2H2C_2', 'GTF2F2', 'TAF6', 'TAF7L', 'GTF2F1', 'CDK7', 'TAF11', 'TAF3', 'TAF10', 'TAF5L', 'TAF9B', 'TAF13', 'GTF2A1L', 'TAF15', 'TAF4B', 'TAF1L', 'TAF6L', 'GTF2H3', 'GTF2I', 'GTF2IRD1', 'GTF2E1'}, 'Nucleotide excision repair Homo sapiens hsa03420': {'ERCC2', 'DDB1', 'ERCC8', 'GTF2H4', 'GTF2H5', 'ERCC4', 'RBX1', 'POLE3', 'LIG1', 'GTF2H2C', 'CCNH', 'RPA3', 'MNAT1', 'ERCC1', 'ERCC3', 'ERCC5', 'XPA', 'RPA2', 'GTF2H2', 'POLE', 'RFC3', 'RPA1', 'GTF2H1', 'GTF2H2C_2', 'POLD3', 'POLD2', 'RAD23A', 'CUL4A', 'BIVM-ERCC5', 'POLD4', 'POLE4', 'CETN2', 'CUL4B', 'CDK7', 'RPA4', 'RFC1', 'RFC2', 'RAD23B', 'POLE2', 'ERCC6', 'RFC4', 'PCNA', 'POLD1', 'DDB2', 'GTF2H3', 'RFC5', 'XPC'}, 'Mismatch repair Homo sapiens hsa03430': {'MLH3', 'MSH2', 'LIG1', 'MSH6', 'RPA3', 'SSBP1', 'RPA2', 'MLH1', 'RFC3', 'RPA1', 'POLD3', 'POLD2', 'POLD4', 'RPA4', 'RFC1', 'RFC2', 'MSH3', 'PCNA', 'RFC4', 'EXO1', 'POLD1', 'RFC5', 'PMS2'}, 'DNA replication Homo sapiens hsa03030': {'PRIM1', 'RNASEH2A', 'MCM4', 'MCM7', 'MCM5', 'POLE3', 'LIG1', 'RPA3', 'SSBP1', 'RNASEH2C', 'RPA2', 'POLA2', 'POLE', 'RFC3', 'RPA1', 'RNASEH2B', 'POLA1', 'POLD3', 'POLD2', 'POLD4', 'RNASEH1', 'POLE4', 'MCM6', 'RPA4', 'DNA2', 'RFC1', 'MCM2', 'RFC2', 'POLE2', 'FEN1', 'PRIM2', 'RFC4', 'PCNA', 'POLD1', 'MCM3', 'RFC5'}, 'Base excision repair Homo sapiens hsa03410': {'PARP4', 'XRCC1', 'UNG', 'LIG3', 'HMGB1', 'NTHL1', 'POLE3', 'LIG1', 'MPG', 'NEIL2', 'APEX1', 'POLL', 'POLB', 'POLE', 'PARP3', 'POLD3', 'POLD2', 'POLD4', 'POLE4', 'MUTYH', 'APEX2', 'OGG1', 'POLE2', 'NEIL1', 'TDG', 'PARP1', 'FEN1', 'MBD4', 'SMUG1', 'PCNA', 'POLD1', 'NEIL3', 'PARP2'}, 'Homologous recombination Homo sapiens hsa03440': {'TOP3A', 'XRCC3', 'RAD51C', 'MRE11A', 'RPA3', 'SSBP1', 'RAD51D', 'EME1', 'XRCC2', 'RPA2', 'MUS81', 'RAD54B', 'RPA1', 'SYCP3', 'RAD50', 'NBN', 'POLD3', 'BRCA2', 'POLD2', 'POLD4', 'RAD52', 'RPA4', 'RAD54L', 'TOP3B', 'BLM', 'POLD1', 'RAD51B', 'SHFM1', 'RAD51'}, 'Fanconi anemia pathway Homo sapiens hsa03460': {'TOP3A', 'HES1', 'PALB2', 'UBE2T', 'FAN1', 'REV3L', 'RAD51C', 'BRIP1', 'RMI1', 'FANCC', 'FANCA', 'BRCA1', 'ERCC4', 'ATRIP', 'EME2', 'RPA3', 'POLK', 'FANCI', 'FANCE', 'SLX1B', 'FANCL', 'POLI', 'ERCC1', 'TELO2', 'FANCM', 'RAD51', 'EME1', 'RPA2', 'C17ORF70', 'MUS81', 'REV1', 'STRA13', 'FANCF', 'MLH1', 'RPA1', 'FANCG', 'FANCB', 'WDR48', 'BRCA2', 'C19ORF40', 'SLX1A', 'RPA4', 'USP1', 'POLH', 'ATR', 'FANCD2', 'APITD1', 'TOP3B', 'POLN', 'BLM', 'SLX4', 'RMI2', 'PMS2'}, 'RNA polymerase Homo sapiens hsa03020': {'POLR2J2', 'POLR3G', 'POLR1B', 'POLR3F', 'POLR2E', 'POLR3C', 'POLR3GL', 'POLR1E', 'POLR2J', 'POLR3B', 'POLR2K', 'POLR2L', 'POLR3H', 'POLR1A', 'POLR3E', 'POLR1D', 'TWISTNB', 'POLR2I', 'POLR1C', 'POLR2F', 'POLR3A', 'POLR2C', 'POLR2A', 'ZNRD1', 'POLR2J3', 'POLR2B', 'POLR3D', 'POLR2G', 'POLR3K', 'POLR2D', 'LOC101060521', 'POLR2H'}, 'Pyrimidine metabolism Homo sapiens hsa00240': {'PRIM1', 'PNP', 'TK1', 'POLR2E', 'NT5C1B', 'POLE3', 'CANT1', 'TYMP', 'NT5C3B', 'POLR3H', 'POLA2', 'DCK', 'NME3', 'DCTPP1', 'DPYD', 'POLR2C', 'RRM2', 'TYMS', 'AK9', 'DHODH', 'POLR2D', 'LOC101060521', 'NME5', 'DPYS', 'UPP1', 'NT5C1B-RDH14', 'ITPA', 'POLR2J', 'CMPK2', 'UCKL1', 'POLR3B', 'POLR2K', 'POLR2L', 'POLR1D', 'TWISTNB', 'POLE', 'POLR2I', 'POLR1C', 'CMPK1', 'POLR3A', 'NT5E', 'POLD3', 'NT5C1A', 'POLD4', 'NME1-NME2', 'NUDT2', 'POLR3K', 'POLR2H', 'DCTD', 'POLR3C', 'POLR3GL', 'NME6', 'PNPT1', 'RRM2B', 'ENTPD8', 'UCK1', 'TK2', 'POLR3E', 'POLR1A', 'TXNRD3', 'POLD2', 'ZNRD1', 'ENTPD6', 'CAD', 'POLR2J3', 'UPRT', 'UMPS', 'PRIM2', 'POLR3D', 'NT5C', 'ENTPD3', 'NT5C3A', 'TXNRD2', 'POLR2J2', 'POLR3G', 'NME4', 'CTPS2', 'POLR1B', 'ENTPD5', 'POLR3F', 'ENTPD4', 'NT5M', 'DUT', 'POLR1E', 'ENTPD1', 'NME7', 'CDA', 'UPP2', 'TXNRD1', 'NME2', 'POLR2F', 'NME1', 'POLR2A', 'POLA1', 'UCK2', 'CTPS1', 'POLE4', 'DTYMK', 'UPB1', 'POLE2', 'POLR2B', 'POLD1', 'POLR2G', 'NT5C2', 'RRM1'}, 'Purine metabolism Homo sapiens hsa00230': {'ADCY9', 'ADCY3', 'PRIM1', 'PNP', 'ADCY6', 'NPR2', 'POLR2E', 'NT5C1B', 'PRUNE', 'PDE5A', 'POLE3', 'CANT1', 'PAICS', 'HDDC3', 'PDE3A', 'PDE6A', 'NT5C3B', 'ENPP1', 'POLR3H', 'POLA2', 'AK8', 'DCK', 'NME3', 'POLR2C', 'GUCY1B3', 'NUDT5', 'AK2', 'RRM2', 'PDE7A', 'ADCY7', 'AK9', 'AMPD3', 'IMPDH1', 'POLR2D', 'LOC390877', 'LOC101060521', 'AK3', 'PDE10A', 'PAPSS2', 'NME5', 'ENPP3', 'HPRT1', 'AK1', 'XDH', 'NT5C1B-RDH14', 'AK5', 'ITPA', 'POLR2J', 'IMPDH2', 'PKLR', 'GMPR2', 'ADCY10', 'GMPS', 'POLR3B', 'POLR2K', 'POLR2L', 'AK4', 'APRT', 'POLR1D', 'TWISTNB', 'PDE4B', 'PRPS2', 'POLR1C', 'CECR1', 'POLE', 'POLR2I', 'POLR3A', 'DGUOK', 'NT5E', 'AMPD1', 'POLD3', 'NTPCR', 'NT5C1A', 'POLD4', 'ADCY4', 'PDE6C', 'AK7', 'PDE1B', 'NME1-NME2', 'GUCY2D', 'ENTPD2', 'NUDT2', 'PDE6H', 'PAPSS1', 'POLR3K', 'NPR1', 'PDE11A', 'POLR2H', 'ATIC', 'PDE6G', 'POLR3C', 'POLR3GL', 'NME6', 'GUCY2C', 'PNPT1', 'RRM2B', 'ENTPD8', 'ADCY2', 'ADCY8', 'PDE3B', 'PDE1A', 'PKM', 'POLR3E', 'POLR1A', 'PDE8B', 'PDE4D', 'URAD', 'GUCY2F', 'ADCY5', 'PDE1C', 'GUCY1A2', 'ADPRM', 'PFAS', 'POLD2', 'PDE6D', 'ZNRD1', 'PDE8A', 'ENTPD6', 'ADA', 'POLR2J3', 'GUK1', 'PRIM2', 'POLR3D', 'NT5C', 'ENTPD3', 'NT5C3A', 'GMPR', 'ADCY1', 'ADSSL1', 'POLR2J2', 'POLR3G', 'NME4', 'POLR1B', 'ENTPD5', 'POLR3F', 'ENTPD4', 'NT5M', 'PRPS1', 'PDE9A', 'PPAT', 'GART', 'POLR1E', 'ENPP4', 'GDA', 'ENTPD1', 'GUCY1A3', 'NME7', 'PDE2A', 'PDE7B', 'ADSL', 'NME2', 'PGM1', 'POLR2F', 'NME1', 'POLR2A', 'POLA1', 'NUDT16', 'AK6', 'PRPS1L1', 'PGM2', 'POLE4', 'ADSS', 'ALLC', 'AMPD2', 'PDE6B', 'POLE2', 'NUDT9', 'POLR2B', 'FHIT', 'ADK', 'PDE4A', 'PDE4C', 'POLD1', 'POLR2G', 'NT5C2', 'RRM1'}, 'Nicotinate and nicotinamide metabolism Homo sapiens hsa00760': {'ENPP3', 'BST1', 'PNP', 'NT5M', 'NT5C1B-RDH14', 'NT5C1B', 'NNT', 'NMNAT2', 'NADSYN1', 'NT5C3B', 'ENPP1', 'NMNAT1', 'NMRK2', 'NT5E', 'NUDT12', 'CD38', 'NT5C1A', 'NAPRT', 'NMNAT3', 'NNMT', 'NMRK1', 'AOX1', 'NT5C', 'NADK2', 'NT5C3A', 'NT5C2', 'QPRT', 'NADK', 'NAMPT'}, 'Non-homologous end-joining Homo sapiens hsa03450': {'XRCC6', 'PRKDC', 'LIG4', 'NHEJ1', 'RAD50', 'FEN1', 'XRCC5', 'DCLRE1C', 'MRE11A', 'XRCC4', 'DNTT', 'POLM', 'POLL'}, 'Primary immunodeficiency Homo sapiens hsa05340': {'RFX5', 'CD4', 'LCK', 'ORAI1', 'LOC102723407', 'PTPRC', 'TNFRSF13C', 'UNG', 'CD19', 'RFXANK', 'RAG1', 'TAP2', 'DCLRE1C', 'TAP1', 'CIITA', 'IGLL1', 'CD3D', 'AIRE', 'IL2RG', 'AICDA', 'RFXAP', 'IL7R', 'CD79A', 'CD3E', 'ZAP70', 'ICOS', 'ADA', 'CD8B', 'BLNK', 'BTK', 'CD8A', 'IKBKG', 'CD40LG', 'JAK3', 'CD40', 'TNFRSF13B', 'RAG2'}, 'ABC transporters Homo sapiens hsa02010': {'ABCD4', 'ABCD1', 'CFTR', 'ABCA8', 'ABCC11', 'ABCB5', 'ABCB9', 'ABCB6', 'ABCG5', 'ABCB8', 'ABCC2', 'ABCB11', 'ABCA12', 'ABCA5', 'ABCA1', 'TAP2', 'TAP1', 'ABCC9', 'ABCA7', 'ABCC1', 'ABCG8', 'ABCB1', 'ABCB7', 'ABCC3', 'ABCB4', 'ABCC6', 'ABCC5', 'ABCG4', 'ABCA10', 'ABCD3', 'ABCA9', 'ABCG2', 'ABCA6', 'ABCG1', 'ABCA3', 'ABCC8', 'ABCA2', 'ABCC10', 'ABCC4', 'ABCB10', 'ABCC12', 'ABCD2', 'ABCA13', 'ABCA4'}, 'Proteasome Homo sapiens hsa03050': {'PSMD14', 'PSMB4', 'PSMD6', 'PSMA3', 'IFNG', 'PSME1', 'PSMA7', 'PSMB6', 'PSMB11', 'PSMA5', 'PSMD11', 'PSMC3', 'PSMD1', 'PSMD13', 'PSMB9', 'PSMD4', 'PSMB10', 'PSMB8', 'PSMC6', 'PSMA6', 'PSMD8', 'PSMD3', 'PSMD2', 'PSMB3', 'PSMC2', 'PSMC5', 'PSME2', 'PSMC1', 'PSMA4', 'PSMC4', 'PSMB1', 'PSMB7', 'PSMA8', 'PSMB5', 'PSME3', 'PSME4', 'PSMF1', 'POMP', 'PSMD12', 'PSMD7', 'PSMB2', 'PSMA1', 'SHFM1', 'PSMA2'}, 'Vitamin B6 metabolism Homo sapiens hsa00750': {'AOX1', 'PDXK', 'PSAT1', 'PHOSPHO2', 'PNPO', 'PDXP'}, 'Nitrogen metabolism Homo sapiens hsa00910': {'CA9', 'CA2', 'CPS1', 'CA12', 'CA5B', 'GLUL', 'CA1', 'CA7', 'CA14', 'CA13', 'GLUD2', 'CA4', 'CA3', 'CA6', 'CA8', 'GLUD1', 'CA5A'}, 'Alanine, aspartate and glutamate metabolism Homo sapiens hsa00250': {'ADSSL1', 'GPT', 'GOT1', 'CPS1', 'RIMKLB', 'ALDH4A1', 'DDO', 'PPAT', 'GLUD1', 'ASL', 'ASS1', 'GLS', 'ASPA', 'GPT2', 'RIMKLA', 'GFPT1', 'GLUD2', 'ABAT', 'ASNS', 'ADSL', 'NIT2', 'IL4I1', 'GLUL', 'GOT2', 'ALDH5A1', 'GAD2', 'NAT8L', 'ADSS', 'CAD', 'AGXT', 'AGXT2', 'GAD1', 'GLS2', 'FOLH1', 'GFPT2'}, 'Arginine biosynthesis Homo sapiens hsa00220': {'GPT', 'GOT1', 'CPS1', 'GLS2', 'ACY1', 'ASL', 'NAGS', 'GLUD1', 'ASS1', 'GLS', 'GPT2', 'GLUD2', 'NOS1', 'GLUL', 'GOT2', 'OTC', 'ARG2', 'NOS3', 'ARG1', 'NOS2'}, 'Proximal tubule bicarbonate reclamation Homo sapiens hsa04964': {'SLC4A4', 'CA2', 'ATP1A3', 'SLC9A3', 'FXYD2', 'SLC38A3', 'ATP1B4', 'ATP1A4', 'CA4', 'ATP1A2', 'AQP1', 'GLUD1', 'GLS', 'MDH1', 'GLUD2', 'ATP1B1', 'SLC25A10', 'ATP1B2', 'PCK2', 'ATP1B3', 'PCK1', 'GLS2', 'ATP1A1'}, 'Mineral absorption Homo sapiens hsa04978': {'MT1A', 'SLC26A6', 'SLC26A9', 'ATP1A3', 'SLC40A1', 'SLC9A3', 'STEAP1', 'ATOX1', 'MT1E', 'CLCN2', 'FXYD2', 'TRPM7', 'ATP1B4', 'ATP1A4', 'ATP1A2', 'SLC11A1', 'SLC31A1', 'ATP2B1', 'CYBRD1', 'MT1X', 'SLC46A1', 'HEPH', 'FTL', 'MT1F', 'ATP1B1', 'SLC30A1', 'HMOX2', 'TRPM6', 'MT2A', 'SLC26A3', 'SLC11A2', 'TRPV6', 'ATP1B2', 'SLC8A1', 'MT1G', 'VDR', 'SLC6A19', 'MT1H', 'SLC5A1', 'SLC39A4', 'HMOX1', 'ATP1B3', 'STEAP2', 'S100G', 'TF', 'ATP7A', 'FTH1', 'MT1B', 'SLC34A2', 'MT1M', 'ATP1A1'}, 'Protein digestion and absorption Homo sapiens hsa04974': {'CPA3', 'ACE2', 'ELN', 'PGA3', 'SLC8A3', 'SLC36A1', 'COL9A1', 'SLC38A2', 'ATP1B1', 'CELA3A', 'COL9A3', 'KCNJ13', 'SLC7A8', 'KCNQ1', 'COL4A2', 'KCNK5', 'CPA2', 'MME', 'XPNPEP2', 'COL10A1', 'SLC1A5', 'DPP4', 'SLC15A1', 'MEP1B', 'COL24A1', 'FXYD2', 'ATP1A4', 'PGA5', 'COL27A1', 'PGA4', 'COL6A6', 'COL5A1', 'COL17A1', 'COL4A1', 'ATP1B2', 'COL21A1', 'SLC8A1', 'COL7A1', 'SLC6A19', 'COL5A2', 'COL12A1', 'COL4A5', 'MEP1A', 'PRSS1', 'COL6A2', 'ATP1A2', 'PRSS3', 'SLC3A2', 'SLC1A1', 'COL6A1', 'COL1A1', 'COL15A1', 'COL13A1', 'COL6A3', 'COL3A1', 'CELA2B', 'SLC8A2', 'COL4A6', 'KCNE3', 'COL5A3', 'COL6A5', 'COL22A1', 'COL14A1', 'PRSS2', 'COL9A2', 'CELA3B', 'SLC7A7', 'ATP1A3', 'SLC9A3', 'CTRB1', 'CPA1', 'ATP1B4', 'COL11A1', 'PRCP', 'KCNN4', 'CTRL', 'COL4A3', 'COL11A2', 'SLC16A10', 'SLC7A9', 'CELA2A', 'SLC3A1', 'CPB1', 'COL4A4', 'COL1A2', 'COL18A1', 'ATP1B3', 'CPB2', 'COL2A1', 'ATP1A1'}, 'Renin-angiotensin system Homo sapiens hsa04614': {'CPA3', 'MAS1', 'ACE2', 'ATP6AP2', 'AGTR2', 'LNPEP', 'CMA1', 'KLK1', 'CTSA', 'PRCP', 'ENPEP', 'THOP1', 'CTSG', 'AGTR1', 'AGT', 'ACE', 'KLK2', 'MME', 'ANPEP', 'PREP', 'REN', 'MRGPRD', 'NLN'}, 'Glutathione metabolism Homo sapiens hsa00480': {'GGT7', 'SMS', 'GCLC', 'MGST3', 'GGT1', 'LAP3', 'GSTO2', 'GPX1', 'MGST2', 'GSS', 'RRM2B', 'TXNDC12', 'GPX3', 'SRM', 'GCLM', 'GSTT2B', 'GGT5', 'GSTA4', 'GSTT1', 'GSTT2', 'IDH2', 'GSTK1', 'GPX4', 'PGD', 'GPX8', 'GSTM5', 'G6PD', 'GSTM3', 'GSTM1', 'GGT6', 'GPX7', 'GPX6', 'HPGDS', 'GGCT', 'RRM2', 'GSTO1', 'GSTA5', 'GSTA3', 'GSTP1', 'GSTA1', 'GSTM2', 'IDH1', 'GPX2', 'OPLAH', 'GSR', 'GSTA2', 'ANPEP', 'GPX5', 'MGST1', 'ODC1', 'RRM1', 'GSTM4'}, 'Cyanoamino acid metabolism Homo sapiens hsa00460': {'GGT7', 'GBA3', 'SHMT2', 'SHMT1', 'GGT6', 'GGT1', 'GGT5'}, 'Taurine and hypotaurine metabolism Homo sapiens hsa00430': {'GGT7', 'ADO', 'CDO1', 'CSAD', 'GADL1', 'GGT6', 'GAD2', 'GGT1', 'GGT5', 'BAAT', 'GAD1'}, 'Caffeine metabolism Homo sapiens hsa00232': {'CYP1A2', 'CYP2A6', 'NAT2', 'NAT1', 'XDH'}, 'Chemical carcinogenesis Homo sapiens hsa05204': {'CYP3A7-CYP3AP1', 'CYP2A13', 'CCBL1', 'UGT2B28', 'CYP1B1', 'UGT2A3', 'CYP2C9', 'CCBL2', 'CYP2C8', 'SULT1A1', 'UGT1A10', 'UGT2B11', 'ADH1C', 'UGT2B17', 'GSTT2', 'UGT2A1', 'GSTM5', 'ADH7', 'UGT1A1', 'ADH1A', 'GSTM2', 'GSTA2', 'SULT1A3', 'ARNT', 'MGST3', 'UGT2A2', 'UGT1A4', 'EPHX1', 'CYP3A5', 'ALDH3A1', 'GSTT1', 'GSTK1', 'CYP2E1', 'NAT2', 'ADH5', 'ALDH3B1', 'GSTA5', 'GSTA3', 'ALDH3B2', 'CYP3A4', 'SULT2A1', 'ADH6', 'UGT1A8', 'GSTM4', 'CYP3A7', 'CYP1A1', 'UGT1A9', 'CYP3A43', 'GSTT2B', 'ADH4', 'CHRNA7', 'PTGS2', 'UGT2B15', 'GSTO1', 'CYP2C19', 'UGT2B4', 'SULT1A4', 'AKR1C2', 'HSD11B1', 'NAT1', 'UGT1A3', 'UGT2B7', 'SULT1A2', 'GSTO2', 'MGST2', 'CYP2C18', 'GSTA4', 'CBR1', 'CYP1A2', 'CYP2A6', 'GSTM1', 'GSTM3', 'HPGDS', 'GSTP1', 'GSTA1', 'UGT1A7', 'UGT1A5', 'ADH1B', 'ALDH1A3', 'UGT1A6', 'UGT2B10', 'MGST1'}, 'Metabolism of xenobiotics by cytochrome P450 Homo sapiens hsa00980': {'CYP2A13', 'CYP2F1', 'CYP2S1', 'UGT2A2', 'CYP1A1', 'UGT2B28', 'UGT2B10', 'MGST3', 'GSTO2', 'CYP1B1', 'UGT2A3', 'AKR1C1', 'AKR7A3', 'MGST2', 'UGT1A9', 'CYP2C9', 'CYP2D6', 'UGT1A4', 'EPHX1', 'CYP3A5', 'UGT1A8', 'UGT1A10', 'ALDH3A1', 'GSTT2B', 'UGT2B11', 'GSTA4', 'GSTT1', 'ADH1C', 'CBR1', 'UGT2B17', 'GSTT2', 'CYP1A2', 'GSTK1', 'CYP2E1', 'UGT2A1', 'CYP2A6', 'ADH5', 'GSTM5', 'ADH4', 'GSTM1', 'GSTM3', 'ADH7', 'HPGDS', 'UGT1A1', 'UGT2B15', 'GSTO1', 'ALDH3B1', 'GSTA5', 'ADH1A', 'CYP2B6', 'UGT2B4', 'GSTA3', 'GSTP1', 'ALDH3B2', 'GSTA1', 'GSTM2', 'CBR3', 'UGT1A7', 'CYP3A4', 'SULT2A1', 'UGT1A5', 'GSTA2', 'ADH1B', 'HSD11B1', 'ALDH1A3', 'UGT1A6', 'AKR7A2', 'UGT1A3', 'UGT2B7', 'ADH6', 'DHDH', 'MGST1', 'GSTM4'}, 'Drug metabolism - cytochrome P450 Homo sapiens hsa00982': {'MGST3', 'MAOA', 'UGT2A2', 'FMO2', 'FMO3', 'UGT2B28', 'GSTO2', 'UGT2A3', 'FMO1', 'MGST2', 'UGT1A9', 'CYP2C9', 'CYP2D6', 'CYP2C8', 'UGT1A4', 'CYP3A5', 'UGT1A8', 'UGT1A10', 'ALDH3A1', 'GSTT2B', 'UGT2B11', 'GSTA4', 'GSTT1', 'ADH1C', 'UGT2B17', 'GSTT2', 'CYP1A2', 'GSTK1', 'FMO4', 'CYP2E1', 'UGT2A1', 'CYP2A6', 'ADH5', 'GSTM5', 'ADH4', 'GSTM1', 'GSTM3', 'ADH7', 'HPGDS', 'UGT1A1', 'UGT2B15', 'GSTO1', 'FMO5', 'CYP2C19', 'MAOB', 'GSTA5', 'ADH1A', 'CYP2B6', 'UGT2B4', 'ALDH3B1', 'GSTA3', 'AOX1', 'GSTP1', 'ALDH3B2', 'GSTA1', 'GSTM2', 'UGT1A7', 'CYP3A4', 'UGT1A5', 'GSTA2', 'ADH1B', 'ALDH1A3', 'UGT1A6', 'UGT1A3', 'UGT2B7', 'ADH6', 'UGT2B10', 'MGST1', 'GSTM4'}, 'Retinol metabolism Homo sapiens hsa00830': {'CYP26B1', 'CYP3A7', 'CYP3A7-CYP3AP1', 'CYP4A11', 'DHRS9', 'UGT2A2', 'CYP1A1', 'CYP2S1', 'UGT2B28', 'DHRS3', 'UGT2A3', 'UGT1A9', 'CYP2C9', 'PNPLA4', 'CYP2C8', 'UGT1A4', 'ALDH1A2', 'CYP3A5', 'CYP2C18', 'UGT1A8', 'UGT1A10', 'DHRS4L1', 'SDR16C5', 'UGT2B11', 'DHRS4', 'CYP26C1', 'ADH1C', 'UGT2B17', 'RDH12', 'HSD17B6', 'CYP1A2', 'UGT2A1', 'CYP2A6', 'DHRS4L2', 'AWAT2', 'ADH4', 'ADH5', 'ADH7', 'UGT1A1', 'UGT2B15', 'ALDH1A1', 'ADH1A', 'CYP2B6', 'UGT2B4', 'LRAT', 'AOX1', 'RDH10', 'DGAT1', 'RETSAT', 'RDH16', 'CYP3A4', 'RDH8', 'UGT1A7', 'UGT1A5', 'ADH1B', 'RDH11', 'RPE65', 'UGT1A6', 'RDH5', 'UGT1A3', 'UGT2B7', 'ADH6', 'UGT2B10', 'CYP26A1', 'BCO1'}, 'Steroid hormone biosynthesis Homo sapiens hsa00140': {'CYP3A7', 'CYP3A7-CYP3AP1', 'SULT2B1', 'CYP11B2', 'UGT2A2', 'CYP1A1', 'UGT2B28', 'HSD17B2', 'HSD3B2', 'AKR1D1', 'CYP1B1', 'UGT2A3', 'AKR1C1', 'HSD17B8', 'AKR1C4', 'UGT1A9', 'CYP11A1', 'SRD5A1', 'UGT1A4', 'CYP17A1', 'CYP3A5', 'SRD5A3', 'AKR1C3', 'UGT1A10', 'UGT1A8', 'UGT2B11', 'HSD3B1', 'UGT2B17', 'HSD17B6', 'SRD5A2', 'CYP1A2', 'CYP7B1', 'HSD17B3', 'CYP2E1', 'UGT2A1', 'HSD11B2', 'SULT1E1', 'HSD17B7', 'UGT1A1', 'UGT2B15', 'UGT2B4', 'HSD17B12', 'STS', 'CYP21A2', 'CYP19A1', 'UGT1A7', 'CYP3A4', 'COMT', 'UGT1A5', 'CYP7A1', 'AKR1C2', 'HSD11B1', 'UGT1A6', 'HSD17B1', 'UGT1A3', 'UGT2B7', 'UGT2B10', 'CYP11B1'}, 'Drug metabolism - other enzymes Homo sapiens hsa00983': {'CES2', 'HPRT1', 'UPP1', 'TK1', 'UGT2A2', 'UGT2B28', 'XDH', 'UGT2A3', 'ITPA', 'UGT1A9', 'TPMT', 'IMPDH2', 'UGT1A4', 'GMPS', 'TYMP', 'UGT1A8', 'UCK1', 'CDA', 'UGT1A10', 'UCKL1', 'UPP2', 'UGT2B11', 'TK2', 'UGT2B17', 'DPYD', 'UGT2A1', 'CYP2A6', 'NAT2', 'UCK2', 'UGT1A1', 'UGT2B15', 'CES1', 'UGT2B4', 'UPB1', 'UMPS', 'UGT1A7', 'CYP3A4', 'UGT1A5', 'UGT1A6', 'NAT1', 'IMPDH1', 'UGT1A3', 'UGT2B7', 'UGT2B10', 'DPYS', 'GUSB'}, 'Porphyrin and chlorophyll metabolism Homo sapiens hsa00860': {'COX10', 'UROD', 'UGT2A2', 'UGT2B28', 'FXN', 'CPOX', 'UGT2A3', 'PPOX', 'UGT1A9', 'ALAD', 'ALAS1', 'UGT1A4', 'HCCS', 'UGT1A8', 'UGT1A10', 'HEPH', 'UGT2B11', 'HMOX2', 'UGT2B17', 'ALAS2', 'UROS', 'UGT2A1', 'FECH', 'UGT1A1', 'UGT2B15', 'CP', 'EPRS', 'BLVRB', 'EARS2', 'UGT2B4', 'MMAB', 'BLVRA', 'UGT1A7', 'HMOX1', 'UGT1A5', 'HMBS', 'UGT1A6', 'UGT1A3', 'UGT2B7', 'COX15', 'UGT2B10', 'GUSB'}, 'Ascorbate and aldarate metabolism Homo sapiens hsa00053': {'ALDH9A1', 'ALDH3A2', 'UGT2A2', 'ALDH2', 'UGT2B28', 'MIOX', 'UGDH', 'UGT2A3', 'UGT1A9', 'UGT1A4', 'UGT1A8', 'UGT1A10', 'RGN', 'UGT2B11', 'UGT2B17', 'UGT2A1', 'UGT1A1', 'UGT2B15', 'UGT2B4', 'UGT1A7', 'ALDH1B1', 'ALDH7A1', 'UGT1A5', 'UGT1A6', 'UGT1A3', 'UGT2B7', 'UGT2B10'}, 'Pentose and glucuronate interconversions Homo sapiens hsa00040': {'AKR1A1', 'XYLB', 'ALDH3A2', 'RPEL1', 'UGT2A2', 'ALDH2', 'UGT2B28', 'UGDH', 'UGT2A3', 'UGT1A9', 'CRYL1', 'DHDH', 'UGT1A4', 'UGT1A8', 'UGT1A10', 'UGT2B11', 'KL', 'RPE', 'UGT2B17', 'UGT2A1', 'SORD', 'AKR1B10', 'UGT1A1', 'UGT2B15', 'UGT2B4', 'UGT1A7', 'ALDH1B1', 'UGT1A5', 'UGT1A6', 'AKR1B1', 'DCXR', 'UGT1A3', 'UGT2B7', 'UGP2', 'UGT2B10', 'GUSB'}, 'Starch and sucrose metabolism Homo sapiens hsa00500': {'GYS2', 'ENPP3', 'G6PC', 'HK2', 'HK1', 'UGT2A2', 'UGT2B28', 'UGDH', 'UGT2A3', 'GPI', 'AMY1C', 'UGT1A9', 'PGM2L1', 'HK3', 'GCK', 'UGT1A4', 'G6PC2', 'GAA', 'HKDC1', 'PYGM', 'UGT1A10', 'GBA3', 'UGT1A8', 'GANC', 'ENPP1', 'UGT2B11', 'KL', 'UXS1', 'UGT2B17', 'AMY2A', 'PGM1', 'G6PC3', 'AMY2B', 'PYGB', 'UGT2A1', 'GBE1', 'PGM2', 'AMY1B', 'UGT1A1', 'UGT2B15', 'AMY1A', 'TREH', 'PYGL', 'UGT2B4', 'UGT1A7', 'UGT1A5', 'MGAM', 'UGT1A6', 'UGT1A3', 'SI', 'UGT2B7', 'UGP2', 'UGT2B10', 'GYS1', 'GUSB', 'AGL'}, 'Galactose metabolism Homo sapiens hsa00052': {'G6PC', 'HK2', 'GLB1', 'HK1', 'GALT', 'HK3', 'GCK', 'GAA', 'G6PC2', 'HKDC1', 'LCT', 'GANC', 'GALK1', 'GALM', 'PGM1', 'G6PC3', 'B4GALT2', 'PGM2', 'AKR1B10', 'GLA', 'PFKM', 'PFKL', 'PFKP', 'MGAM', 'LALBA', 'AKR1B1', 'SI', 'UGP2', 'GALE', 'B4GALT1'}, 'Butirosin and neomycin biosynthesis Homo sapiens hsa00524': {'HK3', 'GCK', 'HKDC1', 'HK2', 'HK1'}, 'Amino sugar and nucleotide sugar metabolism Homo sapiens hsa00520': {'NANS', 'GMPPB', 'GNPNAT1', 'GNE', 'GNPDA1', 'HK2', 'HK1', 'CYB5R3', 'HEXB', 'CYB5R1', 'GALT', 'UGDH', 'GPI', 'HK3', 'GCK', 'CMAS', 'HKDC1', 'TSTA3', 'GFPT1', 'MPI', 'CYB5R2', 'UAP1L1', 'HEXA', 'CHIA', 'GALK1', 'NAGK', 'UXS1', 'CYB5R4', 'AMDHD2', 'CYB5RL', 'GNPDA2', 'PGM1', 'PGM3', 'NANP', 'PMM2', 'GMPPA', 'CHIT1', 'PGM2', 'UAP1', 'NPL', 'RENBP', 'PMM1', 'GMDS', 'UGP2', 'GALE', 'FUK', 'FPGT', 'GFPT2'}, 'Fructose and mannose metabolism Homo sapiens hsa00051': {'ALDOB', 'GMPPB', 'HK2', 'ALDOA', 'TPI1', 'FBP2', 'KHK', 'HK1', 'HK3', 'PFKFB2', 'HKDC1', 'TSTA3', 'MPI', 'ENOSF1', 'ALDOC', 'SORD', 'FBP1', 'PMM2', 'GMPPA', 'AKR1B10', 'PFKM', 'C12ORF5', 'PFKL', 'PFKFB4', 'PMM1', 'GMDS', 'PFKP', 'PFKFB3', 'AKR1B1', 'PFKFB1', 'FUK', 'FPGT'}, 'Pentose phosphate pathway Homo sapiens hsa00030': {'ALDOB', 'RPIA', 'ALDOA', 'FBP2', 'RPEL1', 'PRPS1', 'GPI', 'TKTL1', 'H6PD', 'RGN', 'RPE', 'PRPS2', 'PGM1', 'PGD', 'ALDOC', 'G6PD', 'FBP1', 'PRPS1L1', 'PGM2', 'DERA', 'PFKM', 'PFKL', 'TALDO1', 'PFKP', 'PGLS', 'TKT', 'IDNK', 'RBKS', 'TKTL2'}, 'Carbon metabolism Homo sapiens hsa01200': {'GOT1', 'RPEL1', 'FBP2', 'ESD', 'EHHADH', 'PGAM1', 'AMT', 'H6PD', 'HKDC1', 'RGN', 'CAT', 'RPE', 'SDHB', 'ACADS', 'ME3', 'ALDOC', 'SHMT1', 'ENO3', 'AGXT', 'HIBCH', 'PFKP', 'PSAT1', 'GAPDH', 'ME1', 'ACSS1', 'HK2', 'HADHA', 'HK1', 'MUT', 'DLAT', 'ENO1', 'PCCB', 'IDH3G', 'GPI', 'GLUD1', 'ACAT1', 'SDS', 'PKLR', 'PCCA', 'MDH1', 'GLUD2', 'PRPS2', 'ENO2', 'ADH5', 'G6PD', 'PDHB', 'ECHS1', 'PGAM4', 'SDHD', 'HAO1', 'OGDH', 'PSPH', 'TKT', 'MCEE', 'TKTL2', 'ME2', 'MTHFR', 'CPS1', 'ALDOB', 'RPIA', 'CS', 'ALDOA', 'TPI1', 'TKTL1', 'PGK1', 'PHGDH', 'HK3', 'GCK', 'IDH3B', 'PDHA2', 'ACSS2', 'GPT2', 'SHMT2', 'ACO2', 'PKM', 'SDHC', 'PGP', 'FBP1', 'PDHA1', 'GLDC', 'PFKL', 'FH', 'IDH1', 'DAK', 'SUCLG1', 'IDNK', 'ADPGK', 'OGDHL', 'GPT', 'ACAT2', 'MDH2', 'ACADM', 'PRPS1', 'SUCLG2', 'PGK2', 'HAO2', 'SUCLA2', 'PC', 'PGAM2', 'ACO1', 'DLD', 'IDH2', 'PGD', 'GOT2', 'PRPS1L1', 'IDH3A', 'PFKM', 'DLST', 'ALDH6A1', 'TALDO1', 'PGLS', 'SDSL', 'SDHA'}, 'Biosynthesis of amino acids Homo sapiens hsa01230': {'GPT', 'GOT1', 'CPS1', 'ALDOB', 'ACY1', 'RPIA', 'CS', 'ALDOA', 'TPI1', 'RPEL1', 'PRPS1', 'IDH3G', 'ENO1', 'TAT', 'PGAM1', 'PGK2', 'ASL', 'NAGS', 'TKTL1', 'ASS1', 'PGK1', 'PHGDH', 'SDS', 'MTR', 'PKLR', 'IDH3B', 'AADAT', 'GPT2', 'PC', 'PGAM2', 'SHMT2', 'ACO2', 'ACO1', 'PYCR2', 'ALDH18A1', 'PKM', 'CBS', 'RPE', 'LOC102724560', 'PRPS2', 'IDH2', 'ENO2', 'BCAT2', 'GLUL', 'ALDOC', 'GOT2', 'PRPS1L1', 'CTH', 'SHMT1', 'ENO3', 'IDH3A', 'PAH', 'PFKM', 'OTC', 'PFKL', 'PGAM4', 'MAT2B', 'TALDO1', 'PYCR1', 'IDH1', 'ARG2', 'PFKP', 'ALDH7A1', 'PSAT1', 'MAT2A', 'SDSL', 'BCAT1', 'GAPDH', 'TKT', 'PSPH', 'PYCRL', 'ARG1', 'MAT1A', 'TKTL2'}, '2-Oxocarboxylic acid metabolism Homo sapiens hsa01210': {'GPT', 'GOT1', 'IDH2', 'IDH3B', 'ACY1', 'AADAT', 'IDH1', 'GPT2', 'BCAT2', 'GOT2', 'CS', 'ACO2', 'ACO1', 'IDH3A', 'BCAT1', 'IDH3G', 'NAGS'}, 'Citrate cycle (TCA cycle) Homo sapiens hsa00020': {'MDH2', 'CS', 'DLAT', 'IDH3G', 'SUCLG2', 'SUCLA2', 'IDH3B', 'PDHA2', 'PC', 'ACO2', 'ACO1', 'MDH1', 'DLD', 'SDHC', 'IDH2', 'SDHB', 'IDH3A', 'PDHA1', 'ACLY', 'DLST', 'PCK2', 'PDHB', 'SDHD', 'OGDH', 'FH', 'IDH1', 'PCK1', 'SUCLG1', 'SDHA', 'OGDHL'}, 'Pyruvate metabolism Homo sapiens hsa00620': {'ACSS1', 'ALDH9A1', 'ACAT2', 'MDH2', 'ALDH3A2', 'HAGH', 'GLO1', 'ALDH2', 'LDHD', 'DLAT', 'GRHPR', 'ACAT1', 'ACOT12', 'PKLR', 'PDHA2', 'ACSS2', 'PC', 'ACACA', 'LDHC', 'MDH1', 'PKM', 'DLD', 'HAGHL', 'LDHAL6A', 'ME3', 'LDHA', 'PDHA1', 'ACACB', 'PCK2', 'PDHB', 'FH', 'ALDH1B1', 'ALDH7A1', 'PCK1', 'LDHAL6B', 'ACYP1', 'ACYP2', 'ME1', 'LDHB', 'ME2'}, 'Glycolysis / Gluconeogenesis Homo sapiens hsa00010': {'AKR1A1', 'ACSS1', 'BPGM', 'ALDOB', 'ALDH9A1', 'GAPDHS', 'G6PC', 'ALDH3A2', 'HK2', 'ALDOA', 'TPI1', 'FBP2', 'HK1', 'MINPP1', 'ALDH2', 'ENO1', 'DLAT', 'GPI', 'PGK2', 'PGAM1', 'PGK1', 'HK3', 'GCK', 'PKLR', 'PDHA2', 'ACSS2', 'G6PC2', 'HKDC1', 'PGAM2', 'LDHC', 'ALDH3A1', 'PKM', 'DLD', 'GALM', 'ADH1C', 'LDHAL6A', 'PGM1', 'G6PC3', 'ENO2', 'ALDOC', 'LDHA', 'FBP1', 'ADH4', 'ADH5', 'PGM2', 'ENO3', 'ADH7', 'PDHA1', 'ALDH3B1', 'PFKM', 'ADH1A', 'PDHB', 'PCK2', 'PFKL', 'PGAM4', 'ALDH3B2', 'ALDH1B1', 'PFKP', 'ALDH7A1', 'ADH1B', 'PCK1', 'ALDH1A3', 'LDHAL6B', 'GAPDH', 'ADH6', 'ADPGK', 'LDHB'}, 'Glycine, serine and threonine metabolism Homo sapiens hsa00260': {'GCSH', 'BPGM', 'SRR', 'PIPOX', 'GCAT', 'MAOA', 'GRHPR', 'PGAM1', 'AMT', 'SDS', 'ALAS1', 'PHGDH', 'GAMT', 'PGAM2', 'SHMT2', 'AOC3', 'CHDH', 'GNMT', 'DLD', 'CBS', 'LOC102724560', 'ALAS2', 'DMGDH', 'CTH', 'SHMT1', 'BHMT', 'GLDC', 'MAOB', 'PGAM4', 'AGXT', 'AGXT2', 'AOC2', 'GATM', 'ALDH7A1', 'GLYCTK', 'PSAT1', 'SDSL', 'SARDH', 'PSPH', 'DAO'}, 'Glyoxylate and dicarboxylate metabolism Homo sapiens hsa00630': {'GCSH', 'ACAT2', 'MDH2', 'CS', 'MUT', 'GRHPR', 'PCCB', 'ACAT1', 'AMT', 'HAO2', 'PCCA', 'SHMT2', 'ACO2', 'ACO1', 'MDH1', 'CAT', 'DLD', 'PGP', 'GLUL', 'HOGA1', 'SHMT1', 'GLDC', 'HYI', 'AGXT', 'HAO1', 'GLYCTK', 'AFMID', 'MCEE'}, 'Pantothenate and CoA biosynthesis Homo sapiens hsa00770': {'PANK1', 'ENPP3', 'VNN2', 'DPYD', 'BCAT2', 'PANK2', 'VNN1', 'COASY', 'PPCDC', 'GADL1', 'PANK4', 'PPCS', 'BCAT1', 'PANK3', 'ENPP1', 'DPYS', 'AASDHPPT', 'UPB1'}, 'Cysteine and methionine metabolism Homo sapiens hsa00270': {'GOT1', 'ADI1', 'SMS', 'MDH2', 'GCLC', 'AMD1', 'TAT', 'MRI1', 'MPST', 'GSS', 'SDS', 'MTR', 'SRM', 'GCLM', 'LDHC', 'MDH1', 'AHCY', 'ENOPH1', 'CBS', 'DNMT3A', 'LOC102724560', 'APIP', 'LDHAL6A', 'AHCYL1', 'TST', 'IL4I1', 'BCAT2', 'LDHA', 'GOT2', 'CTH', 'BHMT', 'MAT2B', 'AGXT2', 'BHMT2', 'DNMT3B', 'CDO1', 'AHCYL2', 'MAT2A', 'MTAP', 'LDHAL6B', 'BCAT1', 'SDSL', 'LDHB', 'MAT1A', 'DNMT1'}, 'Phenylalanine, tyrosine and tryptophan biosynthesis Homo sapiens hsa00400': {'GOT1', 'IL4I1', 'GOT2', 'PAH', 'TAT'}, 'Phenylalanine metabolism Homo sapiens hsa00360': {'GOT1', 'ALDH3B2', 'IL4I1', 'AOC2', 'GOT2', 'AOC3', 'ALDH1A3', 'ALDH3A1', 'MAOA', 'GLYAT', 'HPD', 'PAH', 'DDC', 'TAT', 'ALDH3B1', 'MAOB', 'MIF'}, 'Tyrosine metabolism Homo sapiens hsa00350': {'HGD', 'GOT1', 'TPO', 'HPD', 'MAOA', 'TAT', 'PNMT', 'TH', 'AOC3', 'ALDH3A1', 'DBH', 'GSTZ1', 'ADH1C', 'TYRP1', 'IL4I1', 'ADH5', 'GOT2', 'FAHD1', 'ADH4', 'ADH7', 'DDC', 'ALDH3B1', 'MAOB', 'ADH1A', 'MIF', 'AOX1', 'ALDH3B2', 'DCT', 'AOC2', 'COMT', 'ADH1B', 'ALDH1A3', 'FAH', 'ADH6', 'TYR'}, 'Ubiquinone and other terpenoid-quinone biosynthesis Homo sapiens hsa00130': {'VKORC1', 'COQ3', 'COQ5', 'VKORC1L1', 'HPD', 'COQ2', 'COQ7', 'GGCX', 'COQ6', 'TAT', 'NQO1'}, 'Terpenoid backbone biosynthesis Homo sapiens hsa00900': {'IDI2', 'DHDDS', 'ZMPSTE24', 'ACAT2', 'HMGCS1', 'GGPS1', 'PDSS2', 'FNTB', 'NUS1', 'ACAT1', 'HMGCS2', 'PMVK', 'PDSS1', 'FNTA', 'IDI1', 'MVK', 'MVD', 'RCE1', 'PCYOX1', 'ICMT', 'HMGCR', 'FDPS'}, 'Synthesis and degradation of ketone bodies Homo sapiens hsa00072': {'HMGCS2', 'OXCT1', 'ACAT2', 'BDH2', 'HMGCLL1', 'HMGCS1', 'HMGCL', 'OXCT2', 'BDH1', 'ACAT1'}, 'Butanoate metabolism Homo sapiens hsa00650': {'ACSM1', 'ACAT2', 'BDH2', 'HMGCS1', 'HADHA', 'ACSM3', 'EHHADH', 'ACAT1', 'HMGCS2', 'OXCT1', 'HMGCLL1', 'ACSM4', 'ACSM2B', 'ABAT', 'BDH1', 'OXCT2', 'ACSM5', 'ACSM6', 'HADH', 'ACADS', 'ALDH5A1', 'GAD2', 'ECHS1', 'L2HGDH', 'AACS', 'ACSM2A', 'HMGCL', 'GAD1'}, 'Valine, leucine and isoleucine degradation Homo sapiens hsa00280': {'ALDH9A1', 'ACAT2', 'DBT', 'HMGCS1', 'ALDH3A2', 'HADHA', 'MUT', 'ACADM', 'ALDH2', 'PCCB', 'HSD17B10', 'EHHADH', 'ACAT1', 'HMGCS2', 'PCCA', 'OXCT1', 'HMGCLL1', 'IVD', 'ACAD8', 'MCCC2', 'DLD', 'ABAT', 'OXCT2', 'ACAA2', 'IL4I1', 'ACADS', 'ACSF3', 'BCAT2', 'HADH', 'BCKDHB', 'BCKDHA', 'ACADSB', 'HIBADH', 'ALDH6A1', 'ECHS1', 'AGXT2', 'HIBCH', 'AACS', 'HADHB', 'AOX1', 'MCCC1', 'AUH', 'ALDH1B1', 'ALDH7A1', 'BCAT1', 'ACAA1', 'MCEE', 'HMGCL'}, 'Propanoate metabolism Homo sapiens hsa00640': {'ACSS1', 'ACAT2', 'DBT', 'HADHA', 'MUT', 'ACADM', 'PCCB', 'SUCLG2', 'EHHADH', 'ACSS3', 'ACAT1', 'SUCLA2', 'MLYCD', 'PCCA', 'ACSS2', 'ACACA', 'LDHC', 'DLD', 'ABAT', 'LDHAL6A', 'BCKDHB', 'MCEE', 'LDHA', 'BCKDHA', 'ACACB', 'ALDH6A1', 'ECHS1', 'HIBCH', 'ECHDC1', 'LDHAL6B', 'SUCLG1', 'LDHB'}, 'beta-Alanine metabolism Homo sapiens hsa00410': {'CNDP2', 'ALDH9A1', 'SMS', 'ALDH3A2', 'HADHA', 'GADL1', 'ACADM', 'ALDH2', 'CARNS1', 'EHHADH', 'MLYCD', 'SRM', 'AOC3', 'ALDH3A1', 'ABAT', 'SMOX', 'DPYD', 'GAD2', 'ALDH3B1', 'ALDH6A1', 'ECHS1', 'UPB1', 'HIBCH', 'ALDH3B2', 'ALDH1B1', 'AOC2', 'ALDH7A1', 'ALDH1A3', 'DPYS', 'CNDP1', 'GAD1'}, 'Histidine metabolism Homo sapiens hsa00340': {'CNDP2', 'ALDH9A1', 'ALDH3A2', 'MAOA', 'ALDH2', 'UROC1', 'CARNS1', 'ASPA', 'ALDH3A1', 'HNMT', 'HAL', 'FTCD', 'AOC1', 'DDC', 'ALDH3B1', 'MAOB', 'HDC', 'ALDH3B2', 'ALDH1B1', 'C9ORF41', 'ALDH7A1', 'ALDH1A3', 'AMDHD1', 'CNDP1'}, 'Arginine and proline metabolism Homo sapiens hsa00330': {'CKMT1B', 'GOT1', 'CNDP2', 'ARG1', 'ALDH4A1', 'ALDH9A1', 'SMS', 'ALDH3A2', 'MAOA', 'ALDH2', 'LAP3', 'CARNS1', 'CKM', 'AMD1', 'P4HA2', 'PRODH2', 'GAMT', 'SRM', 'PYCR2', 'OAT', 'ALDH18A1', 'NOS1', 'L3HYPDH', 'SMOX', 'SAT1', 'P4HA3', 'HOGA1', 'GOT2', 'AGMAT', 'AOC1', 'CKMT2', 'CKMT1A', 'SAT2', 'MAOB', 'P4HA1', 'LOC102724788', 'PYCR1', 'ARG2', 'ALDH1B1', 'NOS3', 'ALDH7A1', 'GATM', 'CKB', 'PRODH', 'AZIN2', 'PYCRL', 'DAO', 'CNDP1', 'ODC1', 'NOS2'}, 'Tryptophan metabolism Homo sapiens hsa00380': {'ALDH9A1', 'ACAT2', 'CCBL1', 'ALDH3A2', 'HADHA', 'MAOA', 'CYP1A1', 'TPH1', 'TDO2', 'ALDH2', 'CYP1B1', 'EHHADH', 'IDO2', 'ACAT1', 'CCBL2', 'HAAO', 'AADAT', 'IDO1', 'CAT', 'TPH2', 'GCDH', 'CYP1A2', 'IL4I1', 'HADH', 'INMT', 'AOC1', 'DDC', 'KYNU', 'MAOB', 'ECHS1', 'AANAT', 'AOX1', 'OGDH', 'ALDH1B1', 'ASMT', 'ALDH7A1', 'KMO', 'ACMSD', 'AFMID', 'OGDHL'}, 'Lysine degradation Homo sapiens hsa00310': {'PLOD1', 'SUV39H2', 'ACAT2', 'PIPOX', 'ALDH9A1', 'SETD7', 'ALDH3A2', 'SUV420H1', 'HADHA', 'ALDH2', 'TMLHE', 'SUV39H1', 'COLGALT1', 'EHHADH', 'KMT2B', 'EHMT1', 'ACAT1', 'HYKK', 'SUV420H2', 'WHSC1L1', 'AADAT', 'SETDB1', 'KMT2A', 'EHMT2', 'SETD1A', 'WHSC1', 'ASH1L', 'GCDH', 'BBOX1', 'HADH', 'PHYKPL', 'SETDB2', 'COLGALT2', 'SETMAR', 'SETD8', 'KMT2E', 'DLST', 'ECHS1', 'DOT1L', 'OGDH', 'KMT2C', 'CAMKMT', 'ALDH1B1', 'AASS', 'ALDH7A1', 'KMT2D', 'PLOD2', 'SETD1B', 'PLOD3', 'NSD1', 'OGDHL', 'SETD2'}, 'Fatty acid elongation Homo sapiens hsa00062': {'ELOVL4', 'PTPLAD1', 'PTPLAD2', 'HADHA', 'MECR', 'ACOT2', 'PTPLB', 'ACOT4', 'PPT1', 'ACOT1', 'TECR', 'ELOVL2', 'ELOVL1', 'PTPLA', 'ELOVL3', 'ACOT7', 'ACAA2', 'PPT2', 'HADH', 'ELOVL7', 'ECHS1', 'HSD17B12', 'HADHB', 'ELOVL5', 'ELOVL6'}, 'Biosynthesis of unsaturated fatty acids Homo sapiens hsa01040': {'PTPLAD1', 'PTPLAD2', 'ACOX3', 'HADHA', 'ACOT2', 'ACOX1', 'PTPLB', 'ACOT4', 'ACOT1', 'TECR', 'ELOVL2', 'PTPLA', 'BAAT', 'SCD', 'ACOT7', 'FADS1', 'PECR', 'HSD17B12', 'FADS2', 'ELOVL5', 'SCD5', 'ACAA1', 'ELOVL6'}, 'Fatty acid metabolism Homo sapiens hsa01212': {'PTPLAD1', 'ACADL', 'ACSL4', 'PTPLAD2', 'ACAT2', 'ACOX3', 'OXSM', 'CPT1A', 'HADHA', 'MECR', 'ACADM', 'EHHADH', 'ACOX1', 'CPT1C', 'PTPLB', 'ACAT1', 'CPT1B', 'PPT1', 'TECR', 'ELOVL2', 'PTPLA', 'ACACA', 'ACSL3', 'ACADVL', 'SCD', 'ACAA2', 'FADS1', 'ACSL6', 'FASN', 'ACSBG1', 'ACADS', 'PPT2', 'HADH', 'PECR', 'ACADSB', 'ACSL1', 'ECHS1', 'ACSBG2', 'HSD17B12', 'HADHB', 'MCAT', 'FADS2', 'ELOVL5', 'SCD5', 'ACAA1', 'CPT2', 'ELOVL6', 'ACSL5'}, 'Fatty acid degradation Homo sapiens hsa00071': {'ACADL', 'ACSL4', 'ALDH9A1', 'ACAT2', 'ACOX3', 'ALDH3A2', 'CPT1A', 'CYP4A11', 'HADHA', 'ACADM', 'ALDH2', 'EHHADH', 'ACOX1', 'CPT1C', 'ACAT1', 'CPT1B', 'CYP4A22', 'ACSL3', 'ACADVL', 'ACAA2', 'ACSL6', 'GCDH', 'ADH1C', 'ACSBG1', 'ACADS', 'HADH', 'ADH5', 'ADH4', 'ECI1', 'ACADSB', 'ACSL1', 'ADH7', 'ECI2', 'ADH1A', 'ECHS1', 'ACSBG2', 'HADHB', 'ALDH1B1', 'ALDH7A1', 'ADH1B', 'ADH6', 'CPT2', 'ACAA1', 'ACSL5'}, 'Fatty acid biosynthesis Homo sapiens hsa00061': {'FASN', 'ACSBG1', 'ACSL4', 'MCAT', 'OXSM', 'ACSL5', 'ACACA', 'ACSL1', 'ACSL3', 'OLAH', 'ACACB', 'ACSBG2', 'ACSL6'}, 'PPAR signaling pathway Homo sapiens hsa03320': {'ACADL', 'ACSL4', 'ACOX3', 'SORBS1', 'APOA2', 'CPT1A', 'ACADM', 'SLC27A2', 'EHHADH', 'LPL', 'ADIPOQ', 'APOA1', 'ACOX1', 'CPT1C', 'SLC27A5', 'CPT1B', 'GK2', 'HMGCS2', 'FABP2', 'AQP7', 'FABP6', 'ACOX2', 'ACSL3', 'PLIN1', 'APOC3', 'UBC', 'SCD', 'SLC27A4', 'SLC27A1', 'NR1H3', 'SLC27A6', 'ACSL6', 'ACSBG1', 'RXRA', 'PLTP', 'ANGPTL4', 'DBI', 'ACSL1', 'FABP7', 'PPARA', 'MMP1', 'FABP3', 'PPARG', 'SCP2', 'RXRG', 'GK', 'PCK2', 'CYP27A1', 'PDPK1', 'ACSBG2', 'ILK', 'FABP1', 'OLR1', 'CD36', 'RXRB', 'FABP5', 'FADS2', 'PPARD', 'CYP7A1', 'PCK1', 'UCP1', 'SCD5', 'FABP4', 'CYP8B1', 'ACAA1', 'CPT2', 'APOA5', 'ME1', 'ACSL5'}, 'Primary bile acid biosynthesis Homo sapiens hsa00120': {'ACOT8', 'AKR1C4', 'CYP7B1', 'HSD17B4', 'CYP7A1', 'CYP39A1', 'CH25H', 'ACOX2', 'CYP8B1', 'CYP46A1', 'AKR1D1', 'HSD3B7', 'BAAT', 'CYP27A1', 'SCP2', 'SLC27A5', 'AMACR'}, 'Peroxisome Homo sapiens hsa04146': {'ACSL4', 'PIPOX', 'PHYH', 'EHHADH', 'PEX6', 'DHRS4L1', 'PEX26', 'CAT', 'PEX10', 'PXMP2', 'PECR', 'PEX3', 'ACSL1', 'PEX16', 'MVK', 'AGXT', 'PRDX5', 'DECR2', 'NUDT7', 'ACAA1', 'NUDT19', 'PEX5', 'PRDX1', 'ACOX3', 'XDH', 'GNPAT', 'ACOX1', 'PEX5L', 'PEX7', 'HSD17B4', 'PEX1', 'EPHX2', 'AMACR', 'GSTK1', 'FAR2', 'MPV17L', 'HAO1', 'ECH1', 'DAO', 'NOS2', 'PEX11B', 'AGPS', 'DDO', 'SLC27A2', 'MPV17', 'PEX19', 'ACOT8', 'PEX13', 'FAR1', 'PXMP4', 'PEX11G', 'ACSL3', 'SLC25A17', 'ACSL6', 'PAOX', 'NUDT12', 'CRAT', 'SOD2', 'SCP2', 'ABCD3', 'IDH1', 'MPV17L2', 'ABCD2', 'PEX12', 'ABCD4', 'ABCD1', 'SOD1', 'CROT', 'HAO2', 'MLYCD', 'PMVK', 'HMGCLL1', 'PEX11A', 'ACOX2', 'BAAT', 'DHRS4', 'IDH2', 'PEX2', 'PEX14', 'ECI2', 'HACL1', 'HMGCL', 'ACSL5'}, 'Spliceosome Homo sapiens hsa03040': {'ALYREF', 'PRPF31', 'SNRPB', 'LSM4', 'HNRNPA1L2', 'SF3B6', 'DDX5', 'DDX23', 'SNRNP27', 'ACIN1', 'SRSF8', 'SRSF9', 'SNW1', 'XAB2', 'U2AF1L4', 'PPIE', 'PRPF8', 'DHX15', 'HNRNPC', 'CHERP', 'SNRPA', 'HSPA2', 'U2AF1', 'SNRPD3', 'USP39', 'THOC1', 'SNRPD1', 'BUD31', 'SRSF7', 'EFTUD2', 'SLU7', 'LSM6', 'U2SURP', 'SNRNP40', 'ISY1', 'SRSF10', 'TRA2B', 'DDX39B', 'SF3B5', 'DDX42', 'THOC3', 'NHP2L1', 'DDX46', 'SF3B3', 'HSPA1A', 'HNRNPK', 'HSPA1B', 'SNRPA1', 'HNRNPU', 'SNRPG', 'EIF4A3', 'SRSF2', 'PCBP1', 'PRPF3', 'TXNL4A', 'RBMXL2', 'RP9', 'SMNDC1', 'DHX16', 'LSM2', 'RBM22', 'SF3B1', 'RBM25', 'MAGOHB', 'SF3A1', 'PUF60', 'PLRG1', 'RBM8A', 'SRSF5', 'PPIL1', 'HSPA8', 'SNRPC', 'SF3B4', 'HSPA6', 'SRSF3', 'RBMXL1', 'SNRNP70', 'SRSF1', 'AQR', 'SRSF4', 'SNRPE', 'SYF2', 'WBP11', 'NCBP2', 'SF3A2', 'DHX38', 'RBMX', 'TCERG1', 'SART1', 'RBMXL3', 'PRPF40A', 'SNRPF', 'CDC40', 'SF3A3', 'LSM7', 'PRPF40B', 'CRNKL1', 'HNRNPM', 'CCDC12', 'ZMAT2', 'TRA2A', 'MAGOH', 'CWC15', 'SF3B2', 'LSM5', 'PRPF38A', 'HNRNPA3', 'RBM17', 'DHX8', 'PRPF4', 'PRPF38B', 'NCBP1', 'CDC5L', 'PRPF6', 'RNU6-1', 'LSM3', 'SRSF6', 'BCAS2', 'HSPA1L', 'U2AF2', 'PRPF18', 'SNRPB2', 'PPIH', 'SNRNP200', 'ISY1-RAB43', 'PQBP1', 'HNRNPA1', 'LSM8', 'SNRPD2', 'PHF5A', 'CTNNBL1', 'LOC102724594', 'THOC2', 'PRPF19'}, 'RNA degradation Homo sapiens hsa03018': {'PAPD5', 'LSM4', 'CNOT4', 'BTG2', 'DCP1B', 'C1D', 'PAPD7', 'ENO3', 'TOB2', 'EDC3', 'PFKP', 'WDR61', 'EXOSC1', 'PABPC1', 'LSM6', 'PABPC4', 'LSM1', 'BTG4', 'PAN3', 'CNOT10', 'ENO1', 'DIS3', 'CNOT2', 'ZCCHC7', 'PABPC4L', 'PABPC1L2A', 'PARN', 'MPHOSPH6', 'ENO2', 'PABPC1L2B', 'CNOT8', 'PABPC3', 'TTC37', 'HSPA9', 'DCPS', 'EXOSC10', 'LSM2', 'DCP1A', 'DIS3L', 'BTG1', 'BTG3', 'CNOT6', 'CNOT1', 'PABPC1L', 'PNPT1', 'EXOSC7', 'CNOT7', 'EXOSC2', 'PATL1', 'SKIV2L', 'DCP2', 'EDC4', 'XRN2', 'EXOSC4', 'LSM7', 'PFKL', 'EXOSC9', 'CNOT6L', 'PAN2', 'DHX36', 'TOB1', 'LSM5', 'SKIV2L2', 'RQCD1', 'HSPD1', 'EXOSC8', 'LSM3', 'EXOSC5', 'EXOSC6', 'NUDT16', 'PFKM', 'LSM8', 'DDX6', 'CNOT3', 'PABPC5', 'XRN1', 'EXOSC3'}, 'mRNA surveillance pathway Homo sapiens hsa03015': {'ALYREF', 'PPP2R5B', 'MSI2', 'SMG1', 'PELO', 'NXF1', 'ACIN1', 'GSPT2', 'GSPT1', 'WDR33', 'NXF2B', 'CPSF6', 'PPP2R2C', 'CLP1', 'PPP1CA', 'PAPOLG', 'PPP2R1B', 'PPP1CC', 'PABPC1', 'CASC3', 'PABPC4', 'UPF1', 'SMG5', 'WIBG', 'PPP2CB', 'DDX39B', 'PPP2CA', 'CPSF4', 'CSTF3', 'PABPC4L', 'PABPC1L2A', 'SYMPK', 'SMG6', 'PPP2R2B', 'PABPC1L2B', 'PABPC3', 'EIF4A3', 'PPP2R1A', 'CSTF2', 'PPP2R3A', 'CSTF1', 'PPP2R3B', 'MAGOHB', 'SMG7', 'HBS1L', 'PAPOLA', 'PABPC1L', 'NXT1', 'CPSF2', 'NXF3', 'NXF2', 'RBM8A', 'FIP1L1', 'RNGTT', 'PPP2R5D', 'PABPN1', 'PNN', 'UPF3A', 'NCBP2', 'CSTF2T', 'WDR82', 'NXF5', 'PPP2R5C', 'SSU72', 'PPP2R5A', 'PPP2R2A', 'SRRM1', 'MAGOH', 'CPSF3', 'BCL2L2-PABPN1', 'PAPOLB', 'ETF1', 'PPP1CB', 'DAZAP1', 'SAP18', 'UPF3B', 'CPSF7', 'NCBP1', 'PPP2R5E', 'NUDT21', 'RNPS1', 'PABPN1L', 'UPF2', 'PCF11', 'NXT2', 'PPP2R3C', 'RNMT', 'PABPC5', 'CPSF1', 'PPP2R2D', 'MSI1'}, 'RNA transport Homo sapiens hsa03013': {'ALYREF', 'SNORD3C', 'EIF3B', 'AAAS', 'POM121L2', 'NUP98', 'NXF1', 'ACIN1', 'NUPL2', 'NUP214', 'EIF1B', 'RGPD3', 'NUP35', 'EIF3D', 'EIF4G2', 'SEC13', 'EIF2S1', 'UBE2I', 'EIF2B5', 'NDC1', 'SNORD3A', 'NXF2B', 'FXR2', 'EIF4E', 'EIF3A', 'EIF2S2', 'NUP133', 'NUP210', 'CYFIP2', 'THOC1', 'GEMIN8', 'POP4', 'SENP2', 'XPOT', 'EIF3F', 'FMR1', 'SMN1', 'EIF3J', 'RGPD1', 'RANBP2', 'PABPC1', 'LOC101929087', 'CASC3', 'EIF1', 'PABPC4', 'NUP155', 'UPF1', 'NUP188', 'TACC3', 'WIBG', 'RGPD8', 'NUP85', 'DDX39B', 'EIF4B', 'STRAP', 'RPP38', 'THOC3', 'THOC5', 'RPP40', 'PABPC4L', 'PABPC1L2A', 'SNORD3B-1', 'PRMT5', 'PABPC1L2B', 'SUMO3', 'PABPC3', 'EIF4A3', 'DDX20', 'EEF1A2', 'TPR', 'RAN', 'NUP93', 'CLNS1A', 'RPP14', 'MAGOHB', 'TGS1', 'NUP88', 'EIF5', 'GEMIN5', 'PABPC1L', 'NXT1', 'EIF4E2', 'NXF3', 'NXF2', 'RBM8A', 'EIF3G', 'NUP205', 'RPP30', 'XPO1', 'NUP62', 'THOC7', 'EIF3I', 'SUMO4', 'EIF2B4', 'RAE1', 'RGPD4', 'EIF3H', 'SNUPN', 'PNN', 'UPF3A', 'EIF3E', 'NCBP2', 'EIF4EBP3', 'FXR1', 'NXF5', 'TRNT1', 'NUP43', 'EIF4A2', 'POP5', 'NUP107', 'NUP50', 'POM121', 'POM121C', 'CYFIP1', 'XPO5', 'GEMIN6', 'EIF4G1', 'EEF1A1', 'SMN2', 'SRRM1', 'MAGOH', 'EIF2B2', 'POP1', 'ELAC2', 'PHAX', 'NUP210L', 'SAP18', 'RGPD5', 'UPF3B', 'NMD3', 'EIF4A1', 'EIF1AY', 'ELAC1', 'EIF2S3', 'GEMIN2', 'NCBP1', 'SEH1L', 'RNPS1', 'RNU6-1', 'RPP25L', 'NUP54', 'RPP25', 'PAIP1', 'EIF3CL', 'EIF1AX', 'THOC6', 'UPF2', 'NXT2', 'NUP37', 'EIF4EBP2', 'EIF4E1B', 'EIF4G3', 'NUP160', 'EIF5B', 'SNORD3B-2', 'EIF3C', 'EIF4EBP1', 'RPP21', 'GEMIN4', 'NUP153', 'GEMIN7', 'EIF2B1', 'RANGAP1', 'KPNB1', 'SUMO2', 'EIF2B3', 'PABPC5', 'POP7', 'SUMO1', 'THOC2', 'NUPL1', 'RGPD2'}, 'Ribosome biogenesis in eukaryotes Homo sapiens hsa03008': {'FCF1', 'IMP4', 'SNORD3C', 'CSNK2A2', 'CSNK2A1', 'RMRP', 'RBM28', 'NXF1', 'NVL', 'LOC101930111', 'SNORD3A', 'NXF2B', 'SPATA5', 'RNR1', 'GNL3', 'EMG1', 'POP4', 'MPHOSPH10', 'DKC1', 'NOL6', 'NOB1', 'UTP14A', 'REXO2', 'IMP3', 'DROSHA', 'RPP38', 'GAR1', 'NHP2L1', 'RPP40', 'MDN1', 'RNR2', 'SNORD3B-1', 'HEATR1', 'LOC81691', 'LSG1', 'TCOF1', 'EFTUD1', 'RAN', 'WDR3', 'CIRH1A', 'NOP58', 'NXT1', 'NXF3', 'NXF2', 'RPP30', 'XPO1', 'WDR43', 'BMS1', 'WDR75', 'LOC100288562', 'NXF5', 'SBDS', 'UTP6', 'POP5', 'NOP10', 'XRN2', 'RIOK1', 'CSNK2A3', 'UTP14C', 'NHP2', 'RIOK2', 'POP1', 'NMD3', 'CSNK2B', 'LOC643802', 'RCL1', 'RPP25L', 'GNL2', 'RPP25', 'NXT2', 'GTPBP4', 'NOP56', 'UTP18', 'EIF6', 'TBL3', 'AK6', 'SNORD3B-2', 'LOC101929627', 'LOC101929601', 'XRN1', 'REXO1', 'POP7', 'UTP15', 'FBL', 'GNL3L', 'RRP7A', 'NAT10', 'WDR36', 'PWP2'}, 'Ribosome Homo sapiens hsa03010': {'RPL3', 'MRPL28', 'RPL12', 'RPL14', 'RPS8', 'RPS25', 'RPS12', 'RPL24', 'RPL36', 'RPS10', 'MRPS16', 'RPL5', 'RPS15A', 'RPL28', 'RPS23', 'RPS27L', 'RPS9', 'MRPL21', 'MRPS2', 'RPSA', 'RPL26L1', 'RPS16', 'RPL18', 'RPL7', 'RPS29', 'MRPL3', 'RPS14', 'RPL41', 'RPLP0', 'RNR1', 'RPS4Y2', 'RPL30', 'MRPL19', 'RPL10', 'RPL22L1', 'RPLP2', 'RPL9', 'RPLP1', 'MRPL10', 'MRPS21', 'RPS6', 'MRPS14', 'MRPL33', 'RPL19', 'RPL36A-HNRNPH2', 'RPL23A', 'MRPL13', 'RPS26', 'MRPS18A', 'MRPS9', 'RNR2', 'MRPL11', 'RPL27', 'RPL37', 'MRPL17', 'RPL13A', 'RPS20', 'RPL34', 'MRPL27', 'LOC102724828', 'RPL7A', 'RPL35A', 'MRPL2', 'RPL8', 'RPL36AL', 'RPL38', 'RPL3L', 'RPL27A', 'RPS19', 'RPS17', 'MRPL34', 'RPL4', 'RPL32', 'MRPL14', 'MRPS17', 'RPS4Y1', 'RPL17', 'MRPL22', 'RPS28', 'RPS7', 'RPL23', 'MRPL4', 'RPS21', 'MRPL36', 'MRPL15', 'RPS13', 'MRPS10', 'MRPS5', 'MRPS7', 'LOC101929876', 'MRPS15', 'RPL37A', 'FAU', 'MRPS11', 'RPS24', 'RPL6', 'MRPL32', 'MRPL35', 'RPL22', 'MRPS12', 'RPL10L', 'MRPL24', 'RPL11', 'RPS18', 'RPS10-NUDT3', 'RPL26', 'RPS27A', 'UBA52', 'RPL15', 'RPS27', 'MRPL30', 'MRPL9', 'MRPL20', 'RPS5', 'RSL24D1', 'MRPL12', 'RPL35', 'RPL29', 'RPS3', 'RPS4X', 'RPL39', 'RPS15', 'RPS11', 'RPL18A', 'RPL13', 'MRPL16', 'RPS3A', 'RPS2', 'MRPL1', 'MRPL23', 'RPL10A', 'MRPS18C', 'RPL21', 'RPL31', 'MRPL18', 'MRPS6', 'RPL36A'}, 'Folate biosynthesis Homo sapiens hsa00790': {'DHFR', 'ALPP', 'ALPL', 'ALPPL2', 'GCH1', 'GGH', 'MOCS2', 'FPGS', 'SPR', 'QDPR', 'MOCS1', 'ALPI', 'PTS', 'DHFRL1'}, 'One carbon pool by folate Homo sapiens hsa00670': {'MTFMT', 'ATIC', 'MTHFS', 'GART', 'ST20-MTHFS', 'MTHFD2', 'MTHFD1', 'DHFRL1', 'AMT', 'MTHFD2L', 'MTR', 'SHMT2', 'MTHFD1L', 'ALDH1L2', 'FTCD', 'SHMT1', 'TYMS', 'DHFR', 'ALDH1L1', 'MTHFR'}, 'Sulfur relay system Homo sapiens hsa04122': {'MOCS3', 'TST', 'URM1', 'TRMU', 'MOCS2', 'MOCS1', 'CTU2', 'CTU1', 'NFS1', 'MPST'}, 'Sulfur metabolism Homo sapiens hsa00920': {'TST', 'ETHE1', 'PAPSS2', 'SUOX', 'BPNT1', 'PAPSS1', 'SQRDL', 'IMPAD1', 'CYCS', 'MPST'}, 'Selenocompound metabolism Homo sapiens hsa00450': {'TXNRD3', 'CCBL2', 'MTR', 'PAPSS2', 'MARS', 'CCBL1', 'INMT', 'CTH', 'MARS2', 'PAPSS1', 'SCLY', 'SEPSECS', 'TXNRD1', 'TXNRD2', 'SEPHS2', 'PSTK', 'SEPHS1'}, 'Aminoacyl-tRNA biosynthesis Homo sapiens hsa00970': {'MTFMT', 'AARS2', 'IARS2', 'DARS', 'YARS2', 'TRNA', 'TRNN', 'TRNW', 'SARS2', 'MARS', 'TRNC', 'GATB', 'RARS2', 'HARS2', 'SARS', 'TRNM', 'TRNK', 'YARS', 'NARS', 'QRSL1', 'TRNL2', 'IARS', 'WARS2', 'TRNI', 'TRNR', 'FARS2', 'CARS2', 'TRNG', 'TRNF', 'MARS2', 'KARS', 'TARS2', 'TRNS2', 'TARS', 'TARSL2', 'PSTK', 'FARSB', 'CARS', 'DARS2', 'VARS2', 'TRNT', 'TRNQ', 'LARS', 'WARS', 'AARS', 'QARS', 'VARS', 'TRNH', 'TRNE', 'EPRS', 'TRND', 'EARS2', 'PARS2', 'GATC', 'NARS2', 'LARS2', 'TRNP', 'HARS', 'TRNL1', 'RARS', 'TRNV', 'TRNY', 'GARS', 'FARSA', 'SEPSECS', 'TRNS1'}}
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# Container for results
results = []
# Iterate over each module
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
# Check if module_genes_in_expr is empty to avoid issues
if len(module_genes_in_expr) == 0:
continue
# Iterate over each gene set in the GMT file
for gene_set_name, gene_set_genes in pathway_dict.items():
overlap_genes = module_genes_in_expr.intersection(gene_set_genes)
non_overlap_module_genes = module_genes_in_expr.difference(gene_set_genes)
non_overlap_gene_set_genes = gene_set_genes.difference(module_genes_in_expr)
# Calculate the contingency table
a = len(overlap_genes)
b = len(non_overlap_module_genes)
c = len(non_overlap_gene_set_genes)
d = len(set(datExpr.columns)) - (a + b + c) # Adjust d to only consider genes in datExpr
# Ensure all values in the contingency table are non-negative
if a < 0 or b < 0 or c < 0 or d < 0:
continue
# Perform Fisher's exact test only if all values are non-negative
contingency_table = [[a, b], [c, d]]
odds_ratio = None
if b * c != 0:
odds_ratio = (a * d) / (b * c)
results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': a,
'Odds Ratio': odds_ratio,
'P-value': p_value
})
# Container for results
results = []
# Iterate over each module
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
# Check if module_genes_in_expr is empty to avoid issues
if len(module_genes_in_expr) == 0:
continue
# Iterate over each gene set in the GMT file
for gene_set_name, gene_set_genes in pathway_dict.items():
overlap_genes = module_genes_in_expr.intersection(gene_set_genes)
non_overlap_module_genes = module_genes_in_expr.difference(gene_set_genes)
non_overlap_gene_set_genes = gene_set_genes.difference(module_genes_in_expr)
# Calculate the contingency table
a = len(overlap_genes)
b = len(non_overlap_module_genes)
c = len(non_overlap_gene_set_genes)
d = len(set(datExpr.columns)) - (a + b + c) # Adjust d to only consider genes in datExpr
# Ensure all values in the contingency table are non-negative
if a < 0 or b < 0 or c < 0 or d < 0:
continue
# Perform Fisher's exact test only if all values are non-negative
contingency_table = [[a, b], [c, d]]
odds_ratio = None
if b * c != 0:
odds_ratio = (a * d) / (b * c)
results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': a,
'Odds Ratio': odds_ratio,
'P-value': p_value
})
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# Convert results to DataFrame for further analysis
results_df = pd.DataFrame(results)
# Adjust p-values for multiple testing
results_df['Adjusted P-value'] = multipletests(results_df['P-value'], method='fdr_bh')[1]
# Display results
print(results_df)
# Convert results to DataFrame for further analysis
results_df = pd.DataFrame(results)
# Adjust p-values for multiple testing
results_df['Adjusted P-value'] = multipletests(results_df['P-value'], method='fdr_bh')[1]
# Display results
print(results_df)
Module Gene Set \
0 Module_1 Glycosaminoglycan biosynthesis - chondroitin s...
1 Module_1 Glycosaminoglycan biosynthesis - heparan sulfa...
2 Module_1 Glycosylphosphatidylinositol(GPI)-anchor biosy...
3 Module_1 Steroid biosynthesis Homo sapiens hsa00100
4 Module_1 SNARE interactions in vesicular transport Homo...
... ... ...
5251 Module_18 One carbon pool by folate Homo sapiens hsa00670
5252 Module_18 Sulfur relay system Homo sapiens hsa04122
5253 Module_18 Sulfur metabolism Homo sapiens hsa00920
5254 Module_18 Selenocompound metabolism Homo sapiens hsa00450
5255 Module_18 Aminoacyl-tRNA biosynthesis Homo sapiens hsa00970
Overlap Count Odds Ratio P-value Adjusted P-value
0 0 0.0 1.0 1.0
1 0 0.0 1.0 1.0
2 0 0.0 1.0 1.0
3 0 0.0 1.0 1.0
4 0 0.0 1.0 1.0
... ... ... ... ...
5251 0 0.0 1.0 1.0
5252 0 0.0 1.0 1.0
5253 0 0.0 1.0 1.0
5254 0 0.0 1.0 1.0
5255 0 0.0 1.0 1.0
[5256 rows x 6 columns]
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# Filter for Module 1 and sort by overlap count
module_1_results = results_df[results_df['Module'] == 'Module_1']
top_10_enriched_gene_sets = module_1_results.sort_values(by='Overlap Count', ascending=False).head(10)
print(top_10_enriched_gene_sets)
# Filter for Module 1 and sort by overlap count
module_1_results = results_df[results_df['Module'] == 'Module_1']
top_10_enriched_gene_sets = module_1_results.sort_values(by='Overlap Count', ascending=False).head(10)
print(top_10_enriched_gene_sets)
Module Gene Set \
135 Module_1 PI3K-Akt signaling pathway Homo sapiens hsa04151
136 Module_1 Pathways in cancer Homo sapiens hsa05200
48 Module_1 Alcoholism Homo sapiens hsa05034
73 Module_1 Dopaminergic synapse Homo sapiens hsa04728
130 Module_1 Ras signaling pathway Homo sapiens hsa04014
70 Module_1 Retrograde endocannabinoid signaling Homo sapi...
71 Module_1 Glutamatergic synapse Homo sapiens hsa04724
45 Module_1 Cytokine-cytokine receptor interaction Homo sa...
47 Module_1 Transcriptional misregulation in cancer Homo s...
96 Module_1 AMPK signaling pathway Homo sapiens hsa04152
Overlap Count Odds Ratio P-value Adjusted P-value
135 4 0.106645 1.0 1.0
136 3 0.060914 1.0 1.0
48 2 0.125125 1.0 1.0
73 2 0.185966 1.0 1.0
130 2 0.092157 1.0 1.0
70 2 0.246881 1.0 1.0
71 2 0.214811 1.0 1.0
45 2 0.074592 1.0 1.0
47 2 0.124256 1.0 1.0
96 2 0.194793 1.0 1.0
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# Extract data for plotting (top 10 pathways with highest overlap count)
top_10_enriched_gene_sets
y_labels = top_10_enriched_gene_sets['Gene Set']
x = top_10_enriched_gene_sets['Odds Ratio']
sizes = top_10_enriched_gene_sets['Overlap Count'] * 20
p_values = top_10_enriched_gene_sets['P-value']
adjusted_p_values = top_10_enriched_gene_sets['Adjusted P-value']
# Extract data for plotting (top 10 pathways with highest overlap count)
top_10_enriched_gene_sets
y_labels = top_10_enriched_gene_sets['Gene Set']
x = top_10_enriched_gene_sets['Odds Ratio']
sizes = top_10_enriched_gene_sets['Overlap Count'] * 20
p_values = top_10_enriched_gene_sets['P-value']
adjusted_p_values = top_10_enriched_gene_sets['Adjusted P-value']
Visualisation of KEGG Enrichment¶
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# Plot the scatter plot for the top 10 pathways
plt.figure(figsize=(12, 8))
# Main scatter plot
sc = plt.scatter(x, range(10), s=sizes, c=-adjusted_p_values, cmap='viridis', alpha=0.7)
# Set labels and title
plt.yticks(range(10), y_labels) # Set y-axis labels to pathway names
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Pathways')
# Add a legend for dot sizes (overlap count) outside the plot
handles, labels = sc.legend_elements(prop="sizes", alpha=0.6)
legend_labels = [f'Overlap Count: {int(float(label.split("{")[1].split("}")[0]) // 20)}' for label in labels]
legend = plt.legend(handles, legend_labels, loc="center left", bbox_to_anchor=(1.3, 0.5), title="Overlap", frameon=False)
# Add colorbar
cbar = plt.colorbar(sc, shrink=0.2) # Shrink colorbar size
cbar.ax.xaxis.set_label_position('top')
cbar.ax.set_title('Adj.pval', loc='left')
# Adjust layout to prevent overlap between legends
plt.subplots_adjust(right=0.75) # Adjust the right margin to make space for the legends
# Show the plot
plt.grid(True)
plt.tight_layout() # Adjust layout to prevent clipping of labels
plt.show()
# Plot the scatter plot for the top 10 pathways
plt.figure(figsize=(12, 8))
# Main scatter plot
sc = plt.scatter(x, range(10), s=sizes, c=-adjusted_p_values, cmap='viridis', alpha=0.7)
# Set labels and title
plt.yticks(range(10), y_labels) # Set y-axis labels to pathway names
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Pathways')
# Add a legend for dot sizes (overlap count) outside the plot
handles, labels = sc.legend_elements(prop="sizes", alpha=0.6)
legend_labels = [f'Overlap Count: {int(float(label.split("{")[1].split("}")[0]) // 20)}' for label in labels]
legend = plt.legend(handles, legend_labels, loc="center left", bbox_to_anchor=(1.3, 0.5), title="Overlap", frameon=False)
# Add colorbar
cbar = plt.colorbar(sc, shrink=0.2) # Shrink colorbar size
cbar.ax.xaxis.set_label_position('top')
cbar.ax.set_title('Adj.pval', loc='left')
# Adjust layout to prevent overlap between legends
plt.subplots_adjust(right=0.75) # Adjust the right margin to make space for the legends
# Show the plot
plt.grid(True)
plt.tight_layout() # Adjust layout to prevent clipping of labels
plt.show()
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External Reading:
- GSEA website: https://www.gsea-msigdb.org/gsea/index.jsp
- GSEA paper: https://www.pnas.org/doi/10.1073/pnas.0506580102
- Fisher exact test: https://www.pathwaycommons.org/guide/primers/statistics/fishers_exact_test/
- Odd's Ratio: https://www.ncbi.nlm.nih.gov/books/NBK431098/
- Alternative GSEA package: https://maayanlab.cloud/Enrichr/
Exercise Questions:
- What is gene set enrichment analysis?
- What is Fisher Exact Test?
- What is the contingency table in Fisher's Exact Test, and how is it constructed for GSEA?
- What does the odds ratio represent in the context of Fisher's Exact Test?
- What are some potential limitations of using Fisher's Exact Test for enrichment analysis?
- What are some alternatives to Fisher's Exact Test for enrichment analysis?
- How does GSEA differ from use of Fisher Exact Test?
- Enhance the visualisation of enrichment results. Plot a scatter plot for the top 10 enriched gene sets for Module 2. Customise the plot with different color maps and point markers. Annotate the top 3 most significant gene sets on the scatter plot with their names and p-values.
- Think of a different way to visualise the enrichment results instead and plot them. For example, plot a heatmap of overlap counts across modules and gene sets.
- Carry out a correlation analysis of enrichment scores across modules. Investigate the correlation between enrichment scores across different modules to understand how similarly different gene sets are enriched across various modules.
Answers:
GSEA is a computational method used to determine whether predefined sets of genes (gene sets) exhibit statistically significant differences in their expression between two or more biological states or conditions.
The Fisher Exact Test is a statistical significance test used to determine whether there are nonrandom associations between two categorical variables in a contingency table.
A contingency table in Fisher's Exact Test is a 2x2 table that summarizes the counts of observations falling into four categories:
- a: The number of genes that are both in the gene set and in the module.
- b: The number of genes in the module but not in the gene set.
- c: The number of genes in the gene set but not in the module.
- d: The number of genes neither in the gene set nor in the module.
For GSEA, the contingency table helps to compute the odds ratio and p-value, which quantify the enrichment of the gene set in the module.
The odds ratio represents the strength of the association between the gene set and the module. It is calculated as (a * d) / (b * c). A high odds ratio indicates a strong association, meaning that the gene set is more likely to be enriched in the module compared to random expectation.
Potential limitations include:
- Small Sample Sizes: Fisher's Exact Test can be sensitive to very small sample sizes or low counts, leading to unstable results.
- Dependency on Gene Set Size: Enrichment results can be influenced by the size of the gene set, with larger gene sets often showing more significant results due to the increased chance of overlap.
- Multiple Testing: The risk of Type I errors increases when many tests are performed, which necessitates careful adjustment for multiple comparisons.
Alternatives to Fisher's Exact Test include:
- Chi-Square Test: Suitable for larger sample sizes and when the expected frequencies are sufficiently high.
- Hypergeometric Test: Often used in place of Fisher's Exact Test for larger gene sets, providing a similar assessment of enrichment.
- Permutation-Based Methods: Used in GSEA to assess enrichment by comparing observed results to a distribution generated from randomised data.
GSEA focuses on analysing the collective behavior of genes within gene sets to uncover biologically relevant pathways or functional modules. Whereas Fisher Exact Test assesses the significance of associations between individual genes or genomic features and phenotypic categories. GSEA assesses the enrichment of gene sets by comparing the distribution of genes within each set to the overall distribution of genes ranked based on a statistical metric (e.g., differential expression score). It uses a running sum statistic or similar approach to calculate an enrichment score for each gene set and assesses statistical significance based on permutation testing or other methods. Whereas Fisher Exact Test alculates the probability of obtaining the observed distribution of frequencies in a contingency table under the null hypothesis of independence between two categorical variables. It uses the hypergeometric distribution to compute the probability of obtaining as extreme or more extreme frequencies than the observed frequencies.
Answer 8:
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# Filter results for Module_2 and get top 10
module_2_results = results_df[results_df['Module'] == 'Module_2']
top_10_enriched_gene_sets = module_2_results.sort_values(by='Overlap Count', ascending=False).head(10)
# Plot with customisations
plt.figure(figsize=(12, 8))
sc = plt.scatter(
top_10_enriched_gene_sets['Odds Ratio'],
range(10),
s=top_10_enriched_gene_sets['Overlap Count'] * 20,
c=-top_10_enriched_gene_sets['Adjusted P-value'],
cmap='plasma',
alpha=0.7,
edgecolors='w'
)
plt.yticks(range(10), top_10_enriched_gene_sets['Gene Set'])
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Gene Sets for Module_2')
# Annotate top 3
for i in range(3):
plt.text(
top_10_enriched_gene_sets['Odds Ratio'].iloc[i],
i,
f"{top_10_enriched_gene_sets['Gene Set'].iloc[i]} ({top_10_enriched_gene_sets['P-value'].iloc[i]:.2e})",
fontsize=9,
ha='right'
)
# Add colorbar and show plot
cbar = plt.colorbar(sc, shrink=0.2)
cbar.ax.set_title('Adjusted P-value')
plt.grid(True)
plt.tight_layout()
plt.show()
# Filter results for Module_2 and get top 10
module_2_results = results_df[results_df['Module'] == 'Module_2']
top_10_enriched_gene_sets = module_2_results.sort_values(by='Overlap Count', ascending=False).head(10)
# Plot with customisations
plt.figure(figsize=(12, 8))
sc = plt.scatter(
top_10_enriched_gene_sets['Odds Ratio'],
range(10),
s=top_10_enriched_gene_sets['Overlap Count'] * 20,
c=-top_10_enriched_gene_sets['Adjusted P-value'],
cmap='plasma',
alpha=0.7,
edgecolors='w'
)
plt.yticks(range(10), top_10_enriched_gene_sets['Gene Set'])
plt.xlabel('Odds Ratio')
plt.ylabel('Pathway')
plt.title('Top 10 Enriched Gene Sets for Module_2')
# Annotate top 3
for i in range(3):
plt.text(
top_10_enriched_gene_sets['Odds Ratio'].iloc[i],
i,
f"{top_10_enriched_gene_sets['Gene Set'].iloc[i]} ({top_10_enriched_gene_sets['P-value'].iloc[i]:.2e})",
fontsize=9,
ha='right'
)
# Add colorbar and show plot
cbar = plt.colorbar(sc, shrink=0.2)
cbar.ax.set_title('Adjusted P-value')
plt.grid(True)
plt.tight_layout()
plt.show()
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# Example code for Hypergeometric test
results_hypergeo = []
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = len(module_genes_in_expr.intersection(gene_set_genes))
M = len(datExpr.columns) # Total number of genes
n = len(module_genes_in_expr) # Number of genes in the module
N = len(gene_set_genes) # Number of genes in the gene set
p_value = hypergeom.sf(overlap_genes-1, M, N, n)
results_hypergeo.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': overlap_genes,
'P-value': p_value
})
results_hypergeo_df = pd.DataFrame(results_hypergeo)
# Example code for Hypergeometric test
results_hypergeo = []
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(datExpr.columns)
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = len(module_genes_in_expr.intersection(gene_set_genes))
M = len(datExpr.columns) # Total number of genes
n = len(module_genes_in_expr) # Number of genes in the module
N = len(gene_set_genes) # Number of genes in the gene set
p_value = hypergeom.sf(overlap_genes-1, M, N, n)
results_hypergeo.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': overlap_genes,
'P-value': p_value
})
results_hypergeo_df = pd.DataFrame(results_hypergeo)
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results_hypergeo_df
results_hypergeo_df
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| Module | Gene Set | Overlap Count | P-value | |
|---|---|---|---|---|
| 0 | Module_1 | HALLMARK_ADIPOGENESIS | 0 | 1.0 |
| 1 | Module_1 | HALLMARK_ALLOGRAFT_REJECTION | 0 | 1.0 |
| 2 | Module_1 | HALLMARK_ANDROGEN_RESPONSE | 0 | 1.0 |
| 3 | Module_1 | HALLMARK_ANGIOGENESIS | 0 | 1.0 |
| 4 | Module_1 | HALLMARK_APICAL_JUNCTION | 1 | 1.0 |
| ... | ... | ... | ... | ... |
| 895 | Module_18 | HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 0 | 1.0 |
| 896 | Module_18 | HALLMARK_UV_RESPONSE_DN | 0 | 1.0 |
| 897 | Module_18 | HALLMARK_UV_RESPONSE_UP | 0 | 1.0 |
| 898 | Module_18 | HALLMARK_WNT_BETA_CATENIN_SIGNALING | 0 | 1.0 |
| 899 | Module_18 | HALLMARK_XENOBIOTIC_METABOLISM | 0 | 1.0 |
900 rows × 4 columns
Answer 9:
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#Heatmap of Overlap Counts Across Modules and Gene Sets
heatmap_data = results_hypergeo_df.pivot_table(index='Module', columns='Gene Set', values='Overlap Count', fill_value=0)
plt.figure(figsize=(14, 10))
sns.heatmap(heatmap_data, annot=True, cmap='coolwarm', linewidths=0.5)
plt.xlabel('Gene Set')
plt.ylabel('Module')
plt.title('Heatmap of Overlap Counts Across Modules and Gene Sets')
plt.tight_layout()
plt.show()
#Heatmap of Overlap Counts Across Modules and Gene Sets
heatmap_data = results_hypergeo_df.pivot_table(index='Module', columns='Gene Set', values='Overlap Count', fill_value=0)
plt.figure(figsize=(14, 10))
sns.heatmap(heatmap_data, annot=True, cmap='coolwarm', linewidths=0.5)
plt.xlabel('Gene Set')
plt.ylabel('Module')
plt.title('Heatmap of Overlap Counts Across Modules and Gene Sets')
plt.tight_layout()
plt.show()
Answer 10:
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# Define the number of bootstrap samples
n_bootstraps = 50
# Initialize a list to store bootstrap results
bootstrap_results = []
# Original gene expression data
genes = datExpr.columns
# Perform bootstrap sampling
for _ in range(n_bootstraps):
# Sample with replacement
sampled_genes = np.random.choice(genes, size=len(genes), replace=True)
# Create a bootstrap sample of the gene expression data
bootstrap_sample = datExpr[sampled_genes]
# Perform enrichment analysis on this bootstrap sample
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(bootstrap_sample.columns)
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = len(module_genes_in_expr.intersection(gene_set_genes))
M = len(bootstrap_sample.columns)
n = len(module_genes_in_expr)
N = len(gene_set_genes)
p_value = hypergeom.sf(overlap_genes - 1, M, N, n)
# Enrichment score: -log10(p-value) or another suitable metric
enrichment_score = -np.log10(p_value) if p_value > 0 else np.nan
bootstrap_results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': overlap_genes,
'P-value': p_value,
'Enrichment Score': enrichment_score
})
# Convert results to DataFrame
bootstrap_results_df = pd.DataFrame(bootstrap_results)
# Define the number of bootstrap samples
n_bootstraps = 50
# Initialize a list to store bootstrap results
bootstrap_results = []
# Original gene expression data
genes = datExpr.columns
# Perform bootstrap sampling
for _ in range(n_bootstraps):
# Sample with replacement
sampled_genes = np.random.choice(genes, size=len(genes), replace=True)
# Create a bootstrap sample of the gene expression data
bootstrap_sample = datExpr[sampled_genes]
# Perform enrichment analysis on this bootstrap sample
for module_name, module_genes in modules.items():
module_genes_in_expr = module_genes.intersection(bootstrap_sample.columns)
for gene_set_name, gene_set_genes in gene_sets.items():
overlap_genes = len(module_genes_in_expr.intersection(gene_set_genes))
M = len(bootstrap_sample.columns)
n = len(module_genes_in_expr)
N = len(gene_set_genes)
p_value = hypergeom.sf(overlap_genes - 1, M, N, n)
# Enrichment score: -log10(p-value) or another suitable metric
enrichment_score = -np.log10(p_value) if p_value > 0 else np.nan
bootstrap_results.append({
'Module': module_name,
'Gene Set': gene_set_name,
'Overlap Count': overlap_genes,
'P-value': p_value,
'Enrichment Score': enrichment_score
})
# Convert results to DataFrame
bootstrap_results_df = pd.DataFrame(bootstrap_results)
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# Pivot table to get enrichment scores matrix
enrichment_matrix = bootstrap_results_df.pivot_table(
index='Gene Set',
columns='Module',
values='Enrichment Score'
)
# Compute correlation matrix
correlation_matrix = enrichment_matrix.corr()
# Display correlation matrix
print(correlation_matrix)
# Pivot table to get enrichment scores matrix
enrichment_matrix = bootstrap_results_df.pivot_table(
index='Gene Set',
columns='Module',
values='Enrichment Score'
)
# Compute correlation matrix
correlation_matrix = enrichment_matrix.corr()
# Display correlation matrix
print(correlation_matrix)
Module Module_1 Module_10 Module_11 Module_12 Module_13 Module_14 \ Module Module_1 1.000000 -0.041742 NaN -0.020879 NaN NaN Module_10 -0.041742 1.000000 NaN -0.037196 NaN NaN Module_11 NaN NaN NaN NaN NaN NaN Module_12 -0.020879 -0.037196 NaN 1.000000 NaN NaN Module_13 NaN NaN NaN NaN NaN NaN Module_14 NaN NaN NaN NaN NaN NaN Module_15 NaN NaN NaN NaN NaN NaN Module_16 -0.039599 -0.001375 NaN -0.035918 NaN NaN Module_17 NaN NaN NaN NaN NaN NaN Module_18 NaN NaN NaN NaN NaN NaN Module_2 -0.054122 0.026869 NaN -0.047324 NaN NaN Module_3 -0.044642 0.103448 NaN -0.045734 NaN NaN Module_4 -0.034619 0.630023 NaN 0.034529 NaN NaN Module_5 -0.029327 -0.043963 NaN -0.024121 NaN NaN Module_6 -0.008752 0.157690 NaN -0.020408 NaN NaN Module_7 -0.025067 -0.037196 NaN -0.020408 NaN NaN Module_8 -0.028632 -0.065777 NaN 0.575858 NaN NaN Module_9 -0.073110 -0.078937 NaN 0.313387 NaN NaN Module Module_15 Module_16 Module_17 Module_18 Module_2 Module_3 \ Module Module_1 NaN -0.039599 NaN NaN -0.054122 -0.044642 Module_10 NaN -0.001375 NaN NaN 0.026869 0.103448 Module_11 NaN NaN NaN NaN NaN NaN Module_12 NaN -0.035918 NaN NaN -0.047324 -0.045734 Module_13 NaN NaN NaN NaN NaN NaN Module_14 NaN NaN NaN NaN NaN NaN Module_15 NaN NaN NaN NaN NaN NaN Module_16 NaN 1.000000 NaN NaN 0.204235 0.241734 Module_17 NaN NaN NaN NaN NaN NaN Module_18 NaN NaN NaN NaN NaN NaN Module_2 NaN 0.204235 NaN NaN 1.000000 0.197637 Module_3 NaN 0.241734 NaN NaN 0.197637 1.000000 Module_4 NaN -0.020691 NaN NaN -0.038384 -0.064011 Module_5 NaN -0.007456 NaN NaN -0.055933 -0.028076 Module_6 NaN -0.035918 NaN NaN -0.047324 0.527122 Module_7 NaN -0.035918 NaN NaN -0.047324 0.169177 Module_8 NaN -0.063517 NaN NaN -0.083686 -0.007247 Module_9 NaN 0.053462 NaN NaN 0.218570 -0.139025 Module Module_4 Module_5 Module_6 Module_7 Module_8 Module_9 Module Module_1 -0.034619 -0.029327 -0.008752 -0.025067 -0.028632 -0.073110 Module_10 0.630023 -0.043963 0.157690 -0.037196 -0.065777 -0.078937 Module_11 NaN NaN NaN NaN NaN NaN Module_12 0.034529 -0.024121 -0.020408 -0.020408 0.575858 0.313387 Module_13 NaN NaN NaN NaN NaN NaN Module_14 NaN NaN NaN NaN NaN NaN Module_15 NaN NaN NaN NaN NaN NaN Module_16 -0.020691 -0.007456 -0.035918 -0.035918 -0.063517 0.053462 Module_17 NaN NaN NaN NaN NaN NaN Module_18 NaN NaN NaN NaN NaN NaN Module_2 -0.038384 -0.055933 -0.047324 -0.047324 -0.083686 0.218570 Module_3 -0.064011 -0.028076 0.527122 0.169177 -0.007247 -0.139025 Module_4 1.000000 -0.033760 -0.028564 -0.028564 -0.012674 -0.022871 Module_5 -0.033760 1.000000 -0.024121 0.037550 -0.042655 -0.073325 Module_6 -0.028564 -0.024121 1.000000 -0.020408 -0.036089 -0.062039 Module_7 -0.028564 0.037550 -0.020408 1.000000 -0.036089 -0.062039 Module_8 -0.012674 -0.042655 -0.036089 -0.036089 1.000000 0.115438 Module_9 -0.022871 -0.073325 -0.062039 -0.062039 0.115438 1.000000
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plt.figure(figsize=(15, 15))
sns.heatmap(correlation_matrix, annot=True, cmap='coolwarm', vmin=-1, vmax=1)
plt.title('Correlation Heatmap of Enrichment Scores Across Modules')
plt.show()
plt.figure(figsize=(15, 15))
sns.heatmap(correlation_matrix, annot=True, cmap='coolwarm', vmin=-1, vmax=1)
plt.title('Correlation Heatmap of Enrichment Scores Across Modules')
plt.show()
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# List of module names
modules_list = correlation_matrix.columns
num_modules = len(modules_list)
# Ensure there is enough space for subplots
fig, axes = plt.subplots(num_modules - 1, num_modules - 1, figsize=(30, 30), constrained_layout=True)
# Create scatter plots for pairwise comparisons
for i in range(num_modules):
for j in range(i + 1, num_modules):
ax = axes[i, j - 1] if j > i else axes[j - 1, i]
x = enrichment_matrix[modules_list[i]]
y = enrichment_matrix[modules_list[j]]
ax.scatter(x, y, alpha=0.5)
ax.set_xlabel(modules_list[i])
ax.set_ylabel(modules_list[j])
ax.set_title(f'{modules_list[i]} vs {modules_list[j]}')
# Adjust layout to avoid overlapping
plt.tight_layout()
plt.show()
# List of module names
modules_list = correlation_matrix.columns
num_modules = len(modules_list)
# Ensure there is enough space for subplots
fig, axes = plt.subplots(num_modules - 1, num_modules - 1, figsize=(30, 30), constrained_layout=True)
# Create scatter plots for pairwise comparisons
for i in range(num_modules):
for j in range(i + 1, num_modules):
ax = axes[i, j - 1] if j > i else axes[j - 1, i]
x = enrichment_matrix[modules_list[i]]
y = enrichment_matrix[modules_list[j]]
ax.scatter(x, y, alpha=0.5)
ax.set_xlabel(modules_list[i])
ax.set_ylabel(modules_list[j])
ax.set_title(f'{modules_list[i]} vs {modules_list[j]}')
# Adjust layout to avoid overlapping
plt.tight_layout()
plt.show()
/tmp/ipykernel_129598/675437692.py:20: UserWarning: The figure layout has changed to tight plt.tight_layout()
